Dr RR Baliga's "Got Knowledge Doc" Podkast

Oncometabolites and The Heart

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Oncometabolites and The Heart

Dr RR Baliga 'Got Knowledge Doc' PodKasts for Cardio-Oncologists

Baliga RR, Young JB. Energizing Diastole Heart Fail Clin. 2008;4(1):ix‐xiii.

Energizing Diastole

Sulkowski, P.L., Oeck, S., Dow, J. et al. Oncometabolites suppress DNA repair by disrupting local chromatin signalling. Nature (2020).

Tumour metabolites hinder DNA repair

Krebs Cycle Nobel Lecture

Ivosidenib and Cardiogenic Shock

Oncometabolite d-2-hydroxyglutarate impairs α-ketoglutarate dehydrogenase and contractile function in rodent heart. Proc Natl Acad Sci U S A.

D-2-hydroxyglutarate produced by mutant IDH2 causes cardiomyopathy and neurodegeneration in mice. Genes Dev.

Changes in Citric Acid Cycle and Nucleoside Metabolism Are Associated with Anthracycline Cardiotoxicity in Patients with Breast Cancer. J Cardiovasc Transl Res.

Krebs Cycle Primer Khan Academy

Taegtmeyer H, et al Oncometabolic Tracks in the Heart. Circ Res. 2017