Application of Recombinant Antibody (rAb):
desire or requirement for a short circulating half-life in serum;
a smaller biologic that would have broader tissue distribution or the ability to penetrate tumors;
a molecule that can be manufactured in either yeast or E. coli to potentially reduce cost of goods or increase scale of manufacturing;
a molecule lacking an Fc effector functionality to eliminate both cellular responses against the target and potential for dimerization of receptors due to bivalency;
a bispecific antibody fragment, such as has been demonstrated by BiTEs (bispecific T cell engagers; diabodies and most recently, DARTs;
a molecule lacking an Fc effector functionality to eliminate both cellular responses against the target and potential for dimerization of receptors due to bivalency; a molecule that can be manufactured in either yeast or E. coli to potentially reduce cost of goods or increase scale of manufacturing. https://www.creative-biolabs.com/recombinant-antibody.html
