Zybody is engineered by fusing modular recognition domains (MRDs) to N- and C-termini of both the heavy and the light chains of a full-length monoclonal antibody (mAb). It is a multi-specific, multi-valent antibody format that enhances the activity of conventional mAb without compromising their desirable drug-like properties. The MRDs include small polypeptides sequences (< 60 amino acids), domain-based structures selected for target specificity, such as knottins or Protein A Scaffolds, unstructured (linear) or disulfide-constrained peptides. Zybodies possess up to four distinct specificities, depending on the number of MRDs fused to the mAb scaffold, while retaining the original functionality and specificity of the scaffold antibody.
http://www.creativebiolabs.net/zybody.htm
