A book discussing antimicrobial pharmacodynamics (PD), focusing on how drug concentrations relate to therapeutic effects against various pathogens. The content covers general concepts like pharmacokinetic/pharmacodynamic (PK/PD) indices (e.g., AUC/MIC, time above MIC) and their application in determining optimal dosing regimens for different classes of drugs, including $\beta$-lactams, aminoglycosides, quinolones, and antifungals. Several sections address the importance of using in vitro and animal models to predict antibiotic efficacy and prevent the emergence of resistance, emphasizing that the most predictive PK/PD parameter varies by antimicrobial agent and infection type. Finally, the text explores regulatory and economic considerations, such as using PD analysis in setting susceptibility breakpoints and performing pharmacoeconomic evaluations.
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