A clinical manual focusing on drug interactions, primarily mediated by the Cytochrome P450 (P450) enzyme system and drug transporters like ABCB1 (P-glycoprotein). It details the roles of specific P450 enzymes (such as 2D6, 3A4, 2C9, and 2C19) and Phase II metabolism (like glucuronidation) in drug metabolism, including the clinical significance of genetic polymorphisms that affect enzyme activity. Furthermore, the source addresses practical matters and medicolegal implications for clinicians prescribing medications in a polypharmacy environment, emphasizing the need for monitoring drug levels and consulting reliable resources to prevent toxicity. The content is positioned as a practical guide for clinicians published by American Psychiatric Publishing, Inc., but explicitly states that the opinions presented are those of the authors and not official policy.
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