Focused on studying Cyclin-Dependent Kinases (CDKs) and their inhibitors, primarily within the context of cancer, inflammation, and cellular regulation. Several sections detail precise biochemical and molecular techniques, such as various kinase assays, protein purification from recombinant sources, and immunoprecipitation methods to analyze CDK activity and interactions. Furthermore, the text explores advanced strategies for developing new therapeutic agents, including fragment-based de novo design for small molecule inhibitors and peptide inhibitor design, alongside methods for analyzing their effects using techniques like crystallography and metabolomics. Finally, the sources outline complex cellular and in vivo models, including methods for cell synchronization, assessing CDK inhibitor action on mitochondria-mediated apoptosis, and evaluating CDk inhibitors in drug delivery systems and various animal models of disease.
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