Explores the complex, multifaceted role of dopamine (DA) in regulating sleep and wakefulness, detailing how DA receptor subtypes influence the sleep-wake cycle and how disruptions in the DA system relate to neurological and psychiatric disorders. Key areas addressed include the neurobiology of Rapid Eye Movement (REM) sleep, the association between DA dysfunction and conditions such as Parkinson’s Disease (PD), narcolepsy, and depression, and the therapeutic use of dopaminergic agents to manage symptoms like excessive daytime sleepiness and restless legs syndrome (RLS). Furthermore, the text examines the functional interactions between the dopaminergic system and other key regulatory systems, particularly the circadian timing system and the melanin-concentrating hormone (MCH) and hypocretin/orexin systems.
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