Focusing on the complex interplay between antimicrobial agents and other medications. It addresses various mechanisms of drug interactions, including pharmacokinetics (how the body affects the drug) and pharmacodynamics (how the drug affects the body), with a heavy emphasis on the role of the Cytochrome P450 (CYP) enzyme system and transport proteins like P-glycoprotein (P-gp). Specific sections detail interactions involving antiretrovirals for HIV, antifungal agents, tuberculosis treatments, and quinolones, often using case studies to illustrate clinically significant or detrimental outcomes, such as toxicity or therapeutic failure, while also discussing regulatory perspectives on evaluating and labeling these risks.
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