A comprehensive guide for mental health professionals on the complex pharmacokinetic and pharmacodynamic interactions that occur when psychotropic medications are co-administered with other drugs, including anticonvulsants, antihypertensives, and herbals. The book emphasizes the critical role of the cytochrome P450 (CYP) enzyme system in drug metabolism, explaining how inhibition or induction of specific CYP isoforms (such as CYP2D6, CYP3A4, and CYP1A2) can alter drug exposure, leading to loss of therapeutic efficacy or increased toxicity. The text provides clinical scenarios, definitions for key concepts like "victim" and "perpetrator" drugs, and practical advice on avoiding dangerous combinations, such as the potential for serotonin syndrome when mixing certain antidepressants with MAOIs or lithium.
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