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Description

Explores the complex biochemistry of vitamin D, including the synthesis, degradation, and regulation of key enzymes like CYP27B1 and CYP24A1, and the genomic and nongenomic actions of the Vitamin D Receptor (VDR). Specifically, the articles examine vitamin D's controversial yet compelling role in a wide range of conditions, such as infectious diseases (like tuberculosis and HIV), various cancers (like colorectal, prostate, and breast), autoimmune disorders, muscle function, and metabolic diseases (like diabetes and obesity). The consensus highlights that while vitamin D deficiency is frequently associated with these extraskeletal abnormalities, further evidence is needed to establish causality or the definitive benefits of supplementation.

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