An extensive overview, primarily extracted from a pharmacology handbook, concerning estrogens and antiestrogens, detailing their mechanisms, applications, and metabolism. The source addresses the physiological effects of estrogens on various systems and organs, including the cardiovascular system, bone, thyroid, and reproductive tracts in both sexes, emphasizing the differences between genomic and non-genomic actions. A significant portion is dedicated to the chemistry, synthesis, and molecular mechanisms of antiestrogens and selective estrogen receptor modulators (SERMs), compounds used in treating hormone-dependent cancers. Furthermore, the text thoroughly examines the biosynthesis and metabolism of endogenous estrogens, particularly the roles of various metabolizing enzymes and how factors like diet and disease alter estrogen breakdown pathways, suggesting a link between altered metabolism and the risk of certain diseases.
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