A comprehensive pharmaceutical handbook details the engineering principles, manufacturing technologies, and regulatory frameworks surrounding granulation processes. It covers diverse methodologies such as wet, dry, and melt granulation, while examining critical equipment like high-shear mixers, fluid-bed processors, and spray dryers. The text highlights the importance of particle characterization, specifically analyzing how size, solubility, and density influence the final dosage form's quality. Furthermore, it addresses modern industrial advancements, including mathematical modeling, artificial intelligence, and Process Analytical Technology (PAT) for real-time quality control. Finally, the authors provide essential guidance on global compliance standards, risk management, and the specific challenges of formulating nutraceuticals and herbal products.
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