An extensive overview of pharmaceutical science as it relates to topical and transdermal drug delivery, originating from a book written by authors with strong academic and industry backgrounds in the field. The content systematically examines the physicochemical properties of drugs, such as molecular weight and solubility, and how they interact with the skin's barrier, primarily the stratum corneum. Furthermore, the text explores numerous strategies for modulating drug flux, including the use of chemical penetration enhancers, various formulation types (ointments, creams, patches, and nanosystems), and physical enhancement techniques like iontophoresis, microneedles, and sonophoresis. Finally, the source details the critical role of performance testing—specifically in vitro release testing (IVRT) and in vitro permeation/penetration testing (IVPT)—and the considerations involved in process development and manufacturing scale-up for dermal products.
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