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Showing episodes and shows of
Alex LaBossiere
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a16z Podcast
Katherine Boyle: How Tech Can Rebuild America
Why does seriousness feel radical today? a16z General Partner Katherine Boyle joins The LaBossiere Podcast to explore what it means to build for the national interest—and why that starts with purpose.Katherine, part of the American Dynamism team at a16z, shares how we got to a place where public service became uncool, how tech can help rebuild trust in government, and why suffering, friction, and responsibility are essential ingredients for growth. From the collapse of civic duty to the rise of meme-driven politics, they dig into the cultural forces shaping America—and the opportunity to r...
2025-06-30
52 min
LaBossiere Podcast
#55 - Katherine Boyle
Katherine Boyle is a General Partner at Andreessen Horowitz and cofounder of the firm’s American Dynamism practice, which invests in companies supporting the national interest across aerospace, defense, manufacturing, energy, logistics, and critical infrastructure. She sits on the boards of Apex Space and Hadrian Automation and is a board observer for Saronic Technologies and Castelion.She was previously a partner at General Catalyst, where she co-led the firm’s seed practice and invested in the inception rounds of defense technology companies including Anduril Industries and Vannevar Labs. Prior to General Catalyst, she was a ge...
2025-03-06
51 min
LaBossiere Podcast
#54 - Keith Rabois
Keith Rabois is a Managing Partner at Khosla Ventures and the CEO of OpenStore, which acquires small direct-to-consumer businesses. Keith co-founded Opendoor and led the first institutional investments in DoorDash and Affirm. He has early stakes in YouTube, Palantir, Lyft, Airbnb, Eventbrite, and Wish, and also led investments in Faire, Ramp, Trade Republic, and Stripe. He’s regarded as one of the greatest early stage investors.Keith began his career in the industry as a senior executive at PayPal and subsequently served in influential roles at LinkedIn and as chief operating officer of Square. As...
2025-02-20
1h 06
LaBossiere Podcast
#53 - Elad Gil
Elad Gil is a serial entrepreneur, executive, and one of the greatest tech investors of all time, with early stakes in something like 40 billion-plus dollar companies: AirBnB, Anduril, Coinbase, Figma, Flexport, Instacart, Notion, OpenDoor, Pinterest, Square, Stripe… I could really go on. He’s now managing a new billion dollar venture fund, for which he’s the sole investor. Elad is also the co-founder of 2 companies: Color Genomics, a company providing genetic testing, software and clinical services for large-scale health programs – and before that, Mixer Labs, a company building location infrastructure for mobile devices that was acquired by Twitter. He worke...
2024-08-08
1h 16
"Moment of Zen"
The Future of Media, Institutions, and Risk
Today we're sharing a recent interview Erik gave to Alex LaBossiere that covers lots of themes we discuss on Moment of Zen - including Erik's views on tech vs. the media, hypocrisy of the elites, risk orientation, and the thesis behind Turpentine. Grow your newsletter with Beehiiv, head to https://Beehiiv.com and use code "MOZ" for 20% off your first three months--SPONSORS: NETSUITE | BEEHIIV | SQUADNETSUITE📈 NetSuite has 25 years of providing financial software for all your business needs. More than 36,000 businesses have already upgraded to NetSuite by Oracle, gaining vis...
2024-05-05
1h 22
LaBossiere Podcast
#52 - Erik Torenberg
Erik Torenberg is a technology entrepreneur and investor. Presently, he’s the founder of Turpentine. Previously, he was the chairman of On Deck, co-founder and general partner at Village Global, and first employee at Product Hunt. 0:00 - Intro 5:08 - On Investing vs Operating and Being a Player 7:34 - Trust and Direct Distribution 10:45 - Legacy Media and the Techlash 17:24 - What is Turpentine 18:41 - Lessons From 1000 Interviews 20:59 - The Printing Press, Barbells, and the Future of Media 25:22 - Pre-Internet Journalism and Survival of the Fittest Ideas 28:44 - Creator Monetization and Price Discrimination 34:55 - Does...
2024-05-03
1h 18
LaBossiere Podcast
#51 - Bryan Johnson
Bryan Johnson is the world's most measured human. Johnson sold his company, Braintree Venmo, to PayPal for $800m in 2013. Through his Project Blueprint, Johnson has achieved metabolic health equal to the top 1.5% of 18 year olds, inflammation 66% lower than the average 10 year old, and reduced his speed of aging by the equivalent of 31 years. Johnson freely shares his protocols and data publicly for everyone to use. Project Blueprint, is an endeavor to achieve humanity and earth scale cooperation starting within Self. In 2023, Johnson launched Rejuvenation Olympics, a leaderboard assessing one's speed of aging using DNA methylation...
2024-03-21
51 min
LaBossiere Podcast
#50 - Anthony Pompliano
Anthony “Pomp” Pompliano is an entrepreneur and technology investor. He runs his family office which makes private investments, along with owning majority stakes in a number of operating businesses. Additionally, Pomp hosts popular conversations on “The Pomp Podcast,” which has been downloaded more than 50 million times. Pomp also writes a letter that is read by more than 250,000 investors each morning. Pomp’s interests lie at the intersection of finance, technology, entrepreneurship, and economics, which he tweets about extensively to his more than 1.6 million followers. 0:00 - Intro 3:11 - Incumbents and Compet...
2024-01-30
1h 59
LaBossiere Podcast
#49 - Bryan Caplan
Bryan Caplan is a Professor of Economics at George Mason University and a New York Times Bestselling author. He’s the author of 8 books, including The Myth of the Rational Voter, The Case Against Education, and Open Borders: The Science and Ethics of Immigration. His next book, Build, Baby, Build: The Science and Ethics of Housing, will be published by the Cato Institute in 2024. He’s the editor and chief writer for Bet On It, the blog hosted by the Salem Center for Policy at the University of Texas. He’s published in the New York T...
2024-01-09
1h 38
LaBossiere Podcast
#48 - Delian Asparouhov
Delian Asparouhov is the co-founder, President and Chairman of Varda Space Industries, a company building spacecraft to manufacture materials in microgravity that are difficult or impossible to produce on Earth— starting with pharmaceuticals. He’s also a Partner at Founders Fund. Previously, he was a principal at Khosla Ventures, head of growth at Teespring, and founder of a healthcare company called Nightingale. Delian is Bulgarian, attended MIT, and likes to ski and play soccer. 0:00 - Intro 3:14 - How Does Innovation Happen? 6:23 - Varda and the No Science Allowed Rule 7:52 - A Primer on Solid State Micr...
2023-12-12
1h 16
LaBossiere Podcast
#47 - Robin Hanson
Robin Hanson is a professor at George Mason University and researcher at the Future of Humanity Institute at Oxford. 0:00 - Intro 2:42 - Intelligent Life in the Universe 7:30 - Grabby Aliens: A Primer 15:29 - Elites and the End of Global Coordination 18:59 - 6 Hard Steps for the Emergence of Life 22:11 - The Probability of Aliens 33:05 - Domesticating Humans 38:08 - Signaling and the Elephant in the Brain 42:31 - Conscious and Subconscious Behavior 46:53 - Collective Signaling 49:54 - The Contrarian Economics of Medicine and Lifespan 57:00 - Taste 1:01:18 - Hyper-Rationality and Social Cohesion 1:07:03 - How to Predict the Future 1:12:11 - Brain Emulations 1:21:15...
2023-11-30
2h 02
LaBossiere Podcast
#46 - Chris Mason
Chris Mason is a professor of Genomics, Physiology, and Biophysics at Weill Cornell Medicine. He is also one of the founding Directors of the WorldQuant Initiative for Quantitative Prediction. He is the author of The Next 500 Years: Engineering Life to Reach New Worlds, and the co-author of The Age of Prediction: Algorithms, AI, and the Shifting Shadows of Risk. 0:00 - Intro 2:29 - How Long Will Humanity Last? 9:01 - On Societal Pessimism and Long-Term Thinking 13:02 - Aliens! 17:36 - The NASA Twins Study 23:17 - Nature vs Nurture 25:56 - Chris’ Dream Experiments 27:45 - Ge...
2023-11-22
1h 13
LaBossiere Podcast
#45 - Keith Rabois
Keith Rabois is a General Partner at Founders Fund and the CEO of OpenStore, which acquires small direct-to-consumer businesses. Keith co-founded Opendoor and led the first institutional investments in DoorDash and Affirm. He has early stakes in YouTube, Palantir, Lyft, Airbnb, Eventbrite, and Wish, and also led investments in Faire, Ramp, Trade Republic, and Stripe. He’s regarded as one of the greatest early stage investors. Keith began his career in the industry as a senior executive at PayPal and subsequently served in influential roles at LinkedIn and as chief operating officer of Square. As a board member, Keith gu...
2023-11-15
1h 16
LaBossiere Podcast
#44 - Bradley Tusk
Bradley Tusk is a venture capitalist, political strategist, philanthropist and writer. He is the CEO and co-founder of Tusk Ventures, the world’s first venture capital fund that invests solely in early stage startups in highly regulated industries, and the founder of political consulting firm Tusk Strategies. Bradley’s family foundation is funding and leading the national campaign to bring mobile voting to all U.S. elections. Tusk Philanthropies also runs and funds anti-hunger campaigns that have led to the creation of anti-hunger policies and programs (including universal school breakfast programs) in 22 different states, helping to feed over 12.5 million peop...
2023-11-08
1h 30
LaBossiere Podcast
#43 - Jeff Morris Jr.
Jeff Morris Jr is the Managing Partner at Chapter One, an early stage venture capital fund. He’s formerly the VP of Product and Revenue at Tinder, which he helped scale to become the #1 grossing app in the world. 0:00 - Intro 1:57 - Growing up in Silicon Valley 5:01 - Writing, Hollywood, and Tech 13:15 - AI and the Future of Content 21:20 - Dating Apps Today and Time at Tinder 29:26 - Future of Product and Strategy 36:30 - Crypto 40:38 - On Venture Capital 53:19 - Building Chapter One 59:36 - Goals, Mentors, and Personal Philosophy 1:07:56 - $10,000 for Michael Jordan’s Ciga...
2023-10-31
1h 20
The DeSci Podcast
ValleyDAO on Building a Sustainable Future with Synthetic Biology
Welcome to another episode of the DeSci Podcast. In this episode, we were joined by ValleyDAO's Co-founder, Albert Anis, and Communications Lead, Morgan Richards. In this video, Albert Anis and Morgan Richards provide a deep dive into the interesting field of Synthetic Biology, and the significant role that ValleyDAO plays in driving innovation in this area. We also explored the traditional funding model for Synthetic Biology and the difficulties it presents for researchers. They then emphasize the need for a new, decentralized approach to funding and the importance of collaboration in the...
2023-04-03
51 min
The DeSci Podcast
HairDAO: A Community-Led Movement to End Hair Loss For Good
Welcome to another episode of the DeSci Podcast. In this episode, we had the pleasure of talking with Andrew Verbinnen and Andrew Bakst from HairDAO, the second BioDAO ever to mint an IP-NFT. Their mission is to turn hair loss into a problem of the past by funding assets that they believe will accelerate its cure. Throughout the conversation, we delve into a variety of fascinating topics related to hair loss. We explore the bigger picture of this issue and highlight the crucial role of DeSci in expediting the discovery of solutions. And our...
2023-03-22
31 min
The DeSci Podcast
Innovating in Longevity Biotech I Tyler Golato
Welcome to episode Nr. 7 of the DeSci Podcast! In this episode, Tyler Golato, Co-founder and CSO of Molecule DAO joins us as we discuss the problems of scientific research and funding and necessary changes that need to be made in the way funding is done. We talk about the impact of decentralization in research, the requirements for allocating funds for research, and the future of Molecule and Bio-DAOs in general. Tyler also shares his background in biochemistry, molecular biology, and oncology research, and how his experiences led him to Molecule. We hope you enjoy this episode and yo...
2022-12-21
53 min
The DeSci Podcast
Rewarding Negative Findings: Fixing Research and the Future of Science I Patrick Malone
Welcome to episode Nr. 6 of "The DeSci Podcast"! In this episode, Patrick Malone, a physician-scientist turned investor at KDT Ventures where he invests in early-stage life science and healthcare, tells us about what drove his interest in investing in healthcare, what Tech-Bio is, and how it relates to the traditional understanding of Biotech. He also explains, why machine learning is effective in drug discovery, the biggest problem facing scientific research and funding models today, the future of scientific research, and much more. Patrick Malone argued that rewarding negative findings which help to discover what doesn’t work or...
2022-12-14
47 min
LaBossiere Podcast
#42 - Sari Azout
On founding versus Investing, parenting, indexing knowledge, collective intelligence, and good questions.
2022-11-08
41 min
LaBossiere Podcast
#41 - Jason Crawford
On optimism, progress in technology, drivers of stagnation, and how to think about innovation.
2022-10-25
39 min
LaBossiere Podcast
#40 - Samo Burja
On Immortal societies, civilizational decline, the longevity of information, and academia.
2022-10-11
47 min
The DeSci Podcast
Paul Kohlhaas & Vincent Weisser on bio.xyz and the Future of Biotech DAOs
Welcome to Episode Nr. 3 of the DeSci Podcast - Today we're exploring the decentralized science space together with our CEO of Molecule and Vincent Weisser, our Chief Ecosystem Officer! We're incredibly proud to finally speak in depth about our new project bio.xyz - Next to that, we are also digging into a lot of other interesting decentralized science topics. You can find all of them below, so you can skip around to find your favorite ones! Topics & Timestamps: 00:00 - Intro 01:31 - Background Story of Paul 09:27 - Background Story of Vincent 13...
2022-10-06
1h 03
The DeSci Podcast
Balaji Srinivasan - Exploring the Decentralized Science Reformation
Welcome to Episode Nr. 2 of the DeSci Podcast - Today we're exploring the decentralized science reformation together with no other than Balaji Srinivasan! We're incredibly proud to be joined by such a smart and well-known mind as a second guest on "The DeSci Podcast" show! Topics of this episode: → Key factors holding back scientific progress and how to change it (also via DeSci). 🧪 → What role does AI play here? → The future of human optimalism. → How to make predictions in technology? (+ many more & some great advice for DeSci builders at the end from Balaji)
2022-08-04
1h 06
LaBossiere Podcast
#39 - John List
On apologies, academia, quitting, critical thinking, and scaling great ideas.
2022-08-02
53 min
The DeSci Podcast
The First Year of VitaDAO I Tim Peterson, Sebastian Brunemeier & Laurence Ion
Welcome to the very first episode of "The DeSci Podcast" - On this show, we talk to the leaders of the decentralized science world about the future of biotech. Thanks for being here and enjoy the very first episode of this new podcast, brought to you by Molecule. In this first episode, we talk to Tim Peterson, Sebastian Brunemeier & Laurence Ion from @VitaDAO - VitaDAO is the first ever created BioDAO and just recently celebrated its first year anniversary. So we wanted to know - What where the challenges and learnings of this year? How does the fut...
2022-07-07
1h 05
LaBossiere Podcast
#38 - Renée DiResta
On the internet’s biggest problems, social networks as open protocols, and pseudonymity online.
2022-05-19
40 min
LaBossiere Podcast
#37 - Kyle Samani
On risk, thesis-driven investment, and what Kyle thinks people aren’t thinking about enough.
2022-04-20
19 min
LaBossiere Podcast
#36 - Matt Galligan
On falling into tech, communication protocols, pseudonymity and reputation.
2022-03-15
31 min
LaBossiere Podcast
#35 - Anthony Pompliano
On conviction, decentralization, and writing online.
2022-03-01
23 min
LaBossiere Podcast
#34 - Adam Jackson
On marketplaces, community-owned networks, and the future of work.
2022-02-15
35 min
LaBossiere Podcast
#33 - Nadia Eghbal
On academia, how open source works, code as a public good, and journalism.
2022-01-20
28 min
LaBossiere Podcast
#32 - Rory Sutherland
On good storytelling, the brilliance of irrationality, the dangers of institutional behavior, and air fryers.
2022-01-11
52 min
LaBossiere Podcast
#31 - Roneil Rumburg
On dorm room crypto mining, Layer 2 Bitcoin, Web3 disruption, and much more.
2021-12-22
28 min
LaBossiere Podcast
#30 - Peter Diamandis
On curiosity, finding purpose in life, the future of longevity science, and the importance of space.
2021-11-10
25 min
LaBossiere Podcast
#29 - Agnes Callard
On status games, paths in life, persuasion, good parenting, privacy, and God.
2021-11-08
54 min
LaBossiere Podcast
#28 - Albert Wenger
On climate tech, crypto regulation, and writing in public.
2021-11-06
23 min
LaBossiere Podcast
#27 - Vijay Boyapati
On decentralization, geo-politics, and power
2021-11-04
23 min
LaBossiere Podcast
#26 - Sam Corcos
On metabolic health, running a remote company, bio-observability and more.
2021-10-14
42 min
LaBossiere Podcast
#25 - Gaby Goldberg
On forced reflection, breaking into VC, modern friendships, and the new logic of the internet
2021-10-12
28 min
LaBossiere Podcast
#24 - Tyler Cowen
On podcasting, the end of the great stagnation, academia, antitrust, and more.
2021-09-30
21 min
LaBossiere Podcast
#23 - Chris Blattman
On sampling in life, Colombian gangs, and the perpetuation of peace
2021-09-23
29 min
LaBossiere Podcast
#22 - Daniel Gross
On predicting success, angel investing, remote work, and more.
2021-09-16
26 min
LaBossiere Podcast
#21 - Gary Taubes
On navigating education, what good science means, and why we get fat.
2021-09-02
29 min
LaBossiere Podcast
#20 - Blake Robbins
On cold emails, the state of VC, time as wealth, and more.
2021-08-18
30 min
LaBossiere Podcast
#19 - Jude Gomila
The CEO of Golden talks investing, indexing knowledge, and important problems.
2021-08-11
47 min
LaBossiere Podcast
#18 - Jake
The pseudonymous figure talks fame, life decisions, and podcasting.
2021-08-02
45 min
LaBossiere Podcast
#17 - Eric Jorgenson
Eric Jorgenson talks sandwiches, book writing and leverage.
2021-07-26
22 min
LaBossiere Podcast
#16 - Delian Asparouhov
On immigrant beginnings, unconventional paths, and space factories.
2021-07-16
23 min
LaBossiere Podcast
#15 - Amjad Masad
On when startups become corporations, the future of open source, and doing what makes the best story.
2021-07-13
23 min
LaBossiere Podcast
#14 - Peter McCormack
On volcanoes, discovering bitcoin, and anarchism.
2021-07-07
28 min
LaBossiere Podcast
#13 - Rolf Potts
The travel writer and essayist talks time as wealth, why we travel, and the role of social media.
2021-06-28
30 min
LaBossiere Podcast
#12 - Aubrey de Grey
Dr. Aubrey de Grey on the ultimate human problem, why we age, and how we can stop it.
2021-06-25
36 min
LaBossiere Podcast
#11 - Robin Hanson
Professor Robin Hanson on hidden motives, emulating brains, and life in the universe.
2021-06-17
30 min
LaBossiere Podcast
#10 - Eli Dourado
On the great stagnation, transformational technologies, and the future of crypto with Eli Dourado.
2021-06-11
28 min
LaBossiere Podcast
#9 - Beth Comstock
On risk, corporate culture and the necessity of conflict with Beth Comstock, author and former CMO and vice chair at General Electric.
2021-06-03
27 min
LaBossiere Podcast
#8 - Annie Duke
Annie Duke on “right” decisions, when to quit, and hedging your bets.
2021-06-01
35 min
LaBossiere Podcast
#7 - Patri Friedman
Talking poker, cities on the ocean, and anarcho capitalism with the founder of The Seasteading Institute.
2021-05-28
24 min
LaBossiere Podcast
# 6 - Troy Osinoff
On starting young, unconventional paths, and the future of marketing with Troy Osinoff, co-founder of Juice, an award winning digital marketing agency.
2021-05-27
16 min
LaBossiere Podcast
#5 - Bradley Tusk
On politicians, saving Uber, and mobile voting with Bradley Tusk, a man doing everything at once.
2021-05-20
28 min
LaBossiere Podcast
#4 - Ryan Delk
Lessons in building, the state of education, and defining success with the CEO of Primer.
2021-05-19
23 min
LaBossiere Podcast
#3 - Mark Lutter
On building cities from scratch, good governance, and how we’ll live in 2050 with the Founder and Executive Director of the Charter Cities Institute.
2021-05-14
32 min
LaBossiere Podcast
#2 - Megan Smith
Talking personal journey, sustainable development and entrenched biases with the former US CTO and Google VP, now CEO and founder of people-forward innovation company Shift7.
2021-05-06
38 min
LaBossiere Podcast
#1 - Raghuram Rajan
The esteemed economist and former Governor of the Reserve Bank of India talks community, COVID, and inequality.
2021-05-03
30 min
Wanda's Picks
8 AM: Ayana Labossiere, teacher, member, Haiti Action Committee is working with Alex Walker, Vagant Poetics, on a Benefit for Haiti--an open mic for activists at Goodbellies Cafe in Oakland; Robert Roth, teacher, is a co-founder of the Haiti Action Committee and a board member of the Haiti Emergency Relief Fund. 8:30 AM: Jovelyn Richards, playwright, Ms. Pat's House, which is opening at La Pena, August 19; she is joined by director Stephanie Johnson. 9 AM: Kevin Epps, filmmaker, joins us to talk about his film, The Black Rock, a film about blacks incarcerated in the USA's first maxium security prison, and his year...
2011-08-05
2h 11
The Peace Revolution Podcast
Peace Revolution episode 026: Exposing the Folly of an American Theatre of the Absurd
Peace Revolution episode 026: Exposing the Folly of an American Theatre of the Absurd Would you like to know more? Notes, References, and Links for further study: 1. White House video of Obama announcing Osama’s death 2. Good Morning America discovers Osama bin Laden is CIA via Corbett Report 3. Al Qaeda doesn’t exist; courtesy of BBC and Adam Curtis’ film “The Power of Nightmares” 4.  ...
2011-05-08
00 min
The Peace Revolution Podcast (Archive Stream 2006-Present)
Peace Revolution episode 026: Exposing the Folly of an American Theatre of the Absurd
Peace Revolution episode 026: Exposing the Folly of an American Theatre of the Absurd Would you like to know more? Notes, References, and Links for further study: 1. White House video of Obama announcing Osama’s death 2. Good Morning America discovers Osama bin Laden is CIA via Corbett Report 3. Al Qaeda doesn’t exist; courtesy of BBC and Adam Curtis’ film “The Power of Nightmares” 4. The motives behind 9-11 by Steve Pieczenik via the Alex Jones Show a. Osama’s connections to CIA, MI6, and MOSSAD; by Stev...
2011-05-08
2h 59