Shows
a16z PodcastKatherine Boyle: How Tech Can Rebuild AmericaWhy does seriousness feel radical today? a16z General Partner Katherine Boyle joins The LaBossiere Podcast to explore what it means to build for the national interest—and why that starts with purpose.Katherine, part of the American Dynamism team at a16z, shares how we got to a place where public service became uncool, how tech can help rebuild trust in government, and why suffering, friction, and responsibility are essential ingredients for growth. From the collapse of civic duty to the rise of meme-driven politics, they dig into the cultural forces shaping America—and the opportunity to r...2025-06-3052 min
LaBossiere Podcast#55 - Katherine BoyleKatherine Boyle is a General Partner at Andreessen Horowitz and cofounder of the firm’s American Dynamism practice, which invests in companies supporting the national interest across aerospace, defense, manufacturing, energy, logistics, and critical infrastructure. She sits on the boards of Apex Space and Hadrian Automation and is a board observer for Saronic Technologies and Castelion.She was previously a partner at General Catalyst, where she co-led the firm’s seed practice and invested in the inception rounds of defense technology companies including Anduril Industries and Vannevar Labs. Prior to General Catalyst, she was a ge...2025-03-0651 minLaBossiere Podcast#54 - Keith RaboisKeith Rabois is a Managing Partner at Khosla Ventures and the CEO of OpenStore, which acquires small direct-to-consumer businesses. Keith co-founded Opendoor and led the first institutional investments in DoorDash and Affirm. He has early stakes in YouTube, Palantir, Lyft, Airbnb, Eventbrite, and Wish, and also led investments in Faire, Ramp, Trade Republic, and Stripe. He’s regarded as one of the greatest early stage investors.Keith began his career in the industry as a senior executive at PayPal and subsequently served in influential roles at LinkedIn and as chief operating officer of Square. As...2025-02-201h 06LaBossiere Podcast#53 - Elad GilElad Gil is a serial entrepreneur, executive, and one of the greatest tech investors of all time, with early stakes in something like 40 billion-plus dollar companies: AirBnB, Anduril, Coinbase, Figma, Flexport, Instacart, Notion, OpenDoor, Pinterest, Square, Stripe… I could really go on. He’s now managing a new billion dollar venture fund, for which he’s the sole investor.
Elad is also the co-founder of 2 companies: Color Genomics, a company providing genetic testing, software and clinical services for large-scale health programs – and before that, Mixer Labs, a company building location infrastructure for mobile devices that was acquired by Twitter. He worke...2024-08-081h 16
"Moment of Zen"The Future of Media, Institutions, and RiskToday we're sharing a recent interview Erik gave to Alex LaBossiere that covers lots of themes we discuss on Moment of Zen - including Erik's views on tech vs. the media, hypocrisy of the elites, risk orientation, and the thesis behind Turpentine. Grow your newsletter with Beehiiv, head to https://Beehiiv.com and use code "MOZ" for 20% off your first three months--SPONSORS: NETSUITE | BEEHIIV | SQUADNETSUITE📈 NetSuite has 25 years of providing financial software for all your business needs. More than 36,000 businesses have already upgraded to NetSuite by Oracle, gaining vis...2024-05-051h 22LaBossiere Podcast#52 - Erik TorenbergErik Torenberg is a technology entrepreneur and investor.
Presently, he’s the founder of Turpentine. Previously, he was the chairman of On Deck, co-founder and general partner at Village Global, and first employee at Product Hunt.
0:00 - Intro
5:08 - On Investing vs Operating and Being a Player
7:34 - Trust and Direct Distribution
10:45 - Legacy Media and the Techlash
17:24 - What is Turpentine
18:41 - Lessons From 1000 Interviews
20:59 - The Printing Press, Barbells, and the Future of Media
25:22 - Pre-Internet Journalism and Survival of the Fittest Ideas
28:44 - Creator Monetization and Price Discrimination
34:55 - Does...2024-05-031h 18LaBossiere Podcast#51 - Bryan JohnsonBryan Johnson is the world's most measured human. Johnson sold his company, Braintree Venmo, to PayPal for $800m in 2013. Through his Project Blueprint, Johnson has achieved metabolic health equal to the top 1.5% of 18 year olds, inflammation 66% lower than the average 10 year old, and reduced his speed of aging by the equivalent of 31 years.
Johnson freely shares his protocols and data publicly for everyone to use. Project Blueprint, is an endeavor to achieve humanity and earth scale cooperation starting within Self.
In 2023, Johnson launched Rejuvenation Olympics, a leaderboard assessing one's speed of aging using DNA methylation...2024-03-2151 minLaBossiere Podcast#50 - Anthony PomplianoAnthony “Pomp” Pompliano is an entrepreneur and technology investor. He runs his family office which makes private investments, along with owning majority stakes in a number of operating businesses.
Additionally, Pomp hosts popular conversations on “The Pomp Podcast,” which has been downloaded more than 50 million times. Pomp also writes a letter that is read by more than 250,000 investors each morning.
Pomp’s interests lie at the intersection of finance, technology, entrepreneurship, and economics, which he tweets about extensively to his more than 1.6 million followers.
0:00 - Intro
3:11 - Incumbents and Compet...2024-01-301h 59LaBossiere Podcast#49 - Bryan CaplanBryan Caplan is a Professor of Economics at George Mason University and a New York Times Bestselling author.
He’s the author of 8 books, including The Myth of the Rational Voter, The Case Against Education, and Open Borders: The Science and Ethics of Immigration. His next book, Build, Baby, Build: The Science and Ethics of Housing, will be published by the Cato Institute in 2024.
He’s the editor and chief writer for Bet On It, the blog hosted by the Salem Center for Policy at the University of Texas. He’s published in the New York T...2024-01-091h 38LaBossiere Podcast#48 - Delian AsparouhovDelian Asparouhov is the co-founder, President and Chairman of Varda Space Industries, a company building spacecraft to manufacture materials in microgravity that are difficult or impossible to produce on Earth— starting with pharmaceuticals. He’s also a Partner at Founders Fund.
Previously, he was a principal at Khosla Ventures, head of growth at Teespring, and founder of a healthcare company called Nightingale. Delian is Bulgarian, attended MIT, and likes to ski and play soccer.
0:00 - Intro
3:14 - How Does Innovation Happen?
6:23 - Varda and the No Science Allowed Rule
7:52 - A Primer on Solid State Micr...2023-12-121h 16LaBossiere Podcast#47 - Robin HansonRobin Hanson is a professor at George Mason University and researcher at the Future of Humanity Institute at Oxford.
0:00 - Intro
2:42 - Intelligent Life in the Universe
7:30 - Grabby Aliens: A Primer
15:29 - Elites and the End of Global Coordination
18:59 - 6 Hard Steps for the Emergence of Life
22:11 - The Probability of Aliens
33:05 - Domesticating Humans
38:08 - Signaling and the Elephant in the Brain
42:31 - Conscious and Subconscious Behavior
46:53 - Collective Signaling
49:54 - The Contrarian Economics of Medicine and Lifespan
57:00 - Taste
1:01:18 - Hyper-Rationality and Social Cohesion
1:07:03 - How to Predict the Future
1:12:11 - Brain Emulations
1:21:15...2023-11-302h 02LaBossiere Podcast#46 - Chris MasonChris Mason is a professor of Genomics, Physiology, and Biophysics at Weill Cornell Medicine. He is also one of the founding Directors of the WorldQuant Initiative for Quantitative Prediction.
He is the author of The Next 500 Years: Engineering Life to Reach New Worlds, and the co-author of The Age of Prediction: Algorithms, AI, and the Shifting Shadows of Risk.
0:00 - Intro
2:29 - How Long Will Humanity Last?
9:01 - On Societal Pessimism and Long-Term Thinking
13:02 - Aliens!
17:36 - The NASA Twins Study
23:17 - Nature vs Nurture
25:56 - Chris’ Dream Experiments
27:45 - Ge...2023-11-221h 13LaBossiere Podcast#45 - Keith RaboisKeith Rabois is a General Partner at Founders Fund and the CEO of OpenStore, which acquires small direct-to-consumer businesses. Keith co-founded Opendoor and led the first institutional investments in DoorDash and Affirm. He has early stakes in YouTube, Palantir, Lyft, Airbnb, Eventbrite, and Wish, and also led investments in Faire, Ramp, Trade Republic, and Stripe. He’s regarded as one of the greatest early stage investors.
Keith began his career in the industry as a senior executive at PayPal and subsequently served in influential roles at LinkedIn and as chief operating officer of Square. As a board member, Keith gu...2023-11-151h 16LaBossiere Podcast#44 - Bradley TuskBradley Tusk is a venture capitalist, political strategist, philanthropist and writer. He is the CEO and co-founder of Tusk Ventures, the world’s first venture capital fund that invests solely in early stage startups in highly regulated industries, and the founder of political consulting firm Tusk Strategies. Bradley’s family foundation is funding and leading the national campaign to bring mobile voting to all U.S. elections. Tusk Philanthropies also runs and funds anti-hunger campaigns that have led to the creation of anti-hunger policies and programs (including universal school breakfast programs) in 22 different states, helping to feed over 12.5 million peop...2023-11-081h 30LaBossiere Podcast#43 - Jeff Morris Jr.Jeff Morris Jr is the Managing Partner at Chapter One, an early stage venture capital fund. He’s formerly the VP of Product and Revenue at Tinder, which he helped scale to become the #1 grossing app in the world.
0:00 - Intro
1:57 - Growing up in Silicon Valley
5:01 - Writing, Hollywood, and Tech
13:15 - AI and the Future of Content
21:20 - Dating Apps Today and Time at Tinder
29:26 - Future of Product and Strategy
36:30 - Crypto
40:38 - On Venture Capital
53:19 - Building Chapter One
59:36 - Goals, Mentors, and Personal Philosophy
1:07:56 - $10,000 for Michael Jordan’s Ciga...2023-10-311h 20
The DeSci PodcastValleyDAO on Building a Sustainable Future with Synthetic BiologyWelcome to another episode of the DeSci Podcast. In this episode, we were joined by ValleyDAO's Co-founder, Albert Anis, and Communications Lead, Morgan Richards.
In this video, Albert Anis and Morgan Richards provide a deep dive into the interesting field of Synthetic Biology, and the significant role that ValleyDAO plays in driving innovation in this area.
We also explored the traditional funding model for Synthetic Biology and the difficulties it presents for researchers. They then emphasize the need for a new, decentralized approach to funding and the importance of collaboration in the...2023-04-0351 min
The DeSci PodcastHairDAO: A Community-Led Movement to End Hair Loss For GoodWelcome to another episode of the DeSci Podcast. In this episode, we had the pleasure of talking with Andrew Verbinnen and Andrew Bakst from HairDAO, the second BioDAO ever to mint an IP-NFT. Their mission is to turn hair loss into a problem of the past by funding assets that they believe will accelerate its cure. Throughout the conversation, we delve into a variety of fascinating topics related to hair loss.
We explore the bigger picture of this issue and highlight the crucial role of DeSci in expediting the discovery of solutions. And our...2023-03-2231 min
The DeSci PodcastInnovating in Longevity Biotech I Tyler GolatoWelcome to episode Nr. 7 of the DeSci Podcast! In this episode, Tyler Golato, Co-founder and CSO of Molecule DAO joins us as we discuss the problems of scientific research and funding and necessary changes that need to be made in the way funding is done.
We talk about the impact of decentralization in research, the requirements for allocating funds for research, and the future of Molecule and Bio-DAOs in general. Tyler also shares his background in biochemistry, molecular biology, and oncology research, and how his experiences led him to Molecule.
We hope you enjoy this episode and yo...2022-12-2153 min
The DeSci PodcastRewarding Negative Findings: Fixing Research and the Future of Science I Patrick MaloneWelcome to episode Nr. 6 of "The DeSci Podcast"! In this episode, Patrick Malone, a physician-scientist turned investor at KDT Ventures where he invests in early-stage life science and healthcare, tells us about what drove his interest in investing in healthcare, what Tech-Bio is, and how it relates to the traditional understanding of Biotech.
He also explains, why machine learning is effective in drug discovery, the biggest problem facing scientific research and funding models today, the future of scientific research, and much more. Patrick Malone argued that rewarding negative findings which help to discover what doesn’t work or...2022-12-1447 min
LaBossiere Podcast#42 - Sari AzoutOn founding versus Investing, parenting, indexing knowledge, collective intelligence, and good questions.2022-11-0841 min
LaBossiere Podcast#41 - Jason CrawfordOn optimism, progress in technology, drivers of stagnation, and how to think about innovation.2022-10-2539 min
LaBossiere Podcast#40 - Samo BurjaOn Immortal societies, civilizational decline, the longevity of information, and academia.2022-10-1147 min
The DeSci PodcastPaul Kohlhaas & Vincent Weisser on bio.xyz and the Future of Biotech DAOsWelcome to Episode Nr. 3 of the DeSci Podcast - Today we're exploring the decentralized science space together with our CEO of Molecule and Vincent Weisser, our Chief Ecosystem Officer!
We're incredibly proud to finally speak in depth about our new project bio.xyz - Next to that, we are also digging into a lot of other interesting decentralized science topics. You can find all of them below, so you can skip around to find your favorite ones!
Topics & Timestamps:
00:00 - Intro
01:31 - Background Story of Paul
09:27 - Background Story of Vincent
13...2022-10-061h 03
The DeSci PodcastBalaji Srinivasan - Exploring the Decentralized Science ReformationWelcome to Episode Nr. 2 of the DeSci Podcast - Today we're exploring the decentralized science reformation together with no other than Balaji Srinivasan! We're incredibly proud to be joined by such a smart and well-known mind as a second guest on "The DeSci Podcast" show!
Topics of this episode:
→ Key factors holding back scientific progress and how to change it (also via DeSci). 🧪
→ What role does AI play here?
→ The future of human optimalism.
→ How to make predictions in technology?
(+ many more & some great advice for DeSci builders at the end from Balaji)
2022-08-041h 06
LaBossiere Podcast#39 - John ListOn apologies, academia, quitting, critical thinking, and scaling great ideas.2022-08-0253 min
The DeSci PodcastThe First Year of VitaDAO I Tim Peterson, Sebastian Brunemeier & Laurence IonWelcome to the very first episode of "The DeSci Podcast" - On this show, we talk to the leaders of the decentralized science world about the future of biotech. Thanks for being here and enjoy the very first episode of this new podcast, brought to you by Molecule.
In this first episode, we talk to Tim Peterson, Sebastian Brunemeier & Laurence Ion from @VitaDAO - VitaDAO is the first ever created BioDAO and just recently celebrated its first year anniversary. So we wanted to know - What where the challenges and learnings of this year? How does the fut...2022-07-071h 05
LaBossiere Podcast#38 - Renée DiRestaOn the internet’s biggest problems, social networks as open protocols, and pseudonymity online.2022-05-1940 min
LaBossiere Podcast#37 - Kyle SamaniOn risk, thesis-driven investment, and what Kyle thinks people aren’t thinking about enough.2022-04-2019 min
LaBossiere Podcast#36 - Matt GalliganOn falling into tech, communication protocols, pseudonymity and reputation.2022-03-1531 min
LaBossiere Podcast#35 - Anthony PomplianoOn conviction, decentralization, and writing online.2022-03-0123 min
LaBossiere Podcast#34 - Adam JacksonOn marketplaces, community-owned networks, and the future of work.2022-02-1535 min
LaBossiere Podcast#33 - Nadia EghbalOn academia, how open source works, code as a public good, and journalism.2022-01-2028 min
LaBossiere Podcast#32 - Rory SutherlandOn good storytelling, the brilliance of irrationality, the dangers of institutional behavior, and air fryers.2022-01-1152 min
LaBossiere Podcast#31 - Roneil RumburgOn dorm room crypto mining, Layer 2 Bitcoin, Web3 disruption, and much more.2021-12-2228 min
LaBossiere Podcast#30 - Peter DiamandisOn curiosity, finding purpose in life, the future of longevity science, and the importance of space.2021-11-1025 min
LaBossiere Podcast#29 - Agnes CallardOn status games, paths in life, persuasion, good parenting, privacy, and God.2021-11-0854 min
LaBossiere Podcast#28 - Albert WengerOn climate tech, crypto regulation, and writing in public.2021-11-0623 min
LaBossiere Podcast#27 - Vijay BoyapatiOn decentralization, geo-politics, and power2021-11-0423 min
LaBossiere Podcast#26 - Sam CorcosOn metabolic health, running a remote company, bio-observability and more.2021-10-1442 min
LaBossiere Podcast#25 - Gaby GoldbergOn forced reflection, breaking into VC, modern friendships, and the new logic of the internet2021-10-1228 min
LaBossiere Podcast#24 - Tyler CowenOn podcasting, the end of the great stagnation, academia, antitrust, and more.2021-09-3021 min
LaBossiere Podcast#23 - Chris BlattmanOn sampling in life, Colombian gangs, and the perpetuation of peace2021-09-2329 min
LaBossiere Podcast#22 - Daniel GrossOn predicting success, angel investing, remote work, and more.2021-09-1626 min
LaBossiere Podcast#21 - Gary TaubesOn navigating education, what good science means, and why we get fat.2021-09-0229 min
LaBossiere Podcast#20 - Blake RobbinsOn cold emails, the state of VC, time as wealth, and more.2021-08-1830 min
LaBossiere Podcast#19 - Jude GomilaThe CEO of Golden talks investing, indexing knowledge, and important problems.2021-08-1147 min
LaBossiere Podcast#18 - JakeThe pseudonymous figure talks fame, life decisions, and podcasting.2021-08-0245 min
LaBossiere Podcast#17 - Eric JorgensonEric Jorgenson talks sandwiches, book writing and leverage.2021-07-2622 min
LaBossiere Podcast#16 - Delian AsparouhovOn immigrant beginnings, unconventional paths, and space factories.2021-07-1623 min
LaBossiere Podcast#15 - Amjad MasadOn when startups become corporations, the future of open source, and doing what makes the best story.2021-07-1323 min
LaBossiere Podcast#14 - Peter McCormackOn volcanoes, discovering bitcoin, and anarchism.2021-07-0728 min
LaBossiere Podcast#13 - Rolf PottsThe travel writer and essayist talks time as wealth, why we travel, and the role of social media.2021-06-2830 min
LaBossiere Podcast#12 - Aubrey de GreyDr. Aubrey de Grey on the ultimate human problem, why we age, and how we can stop it.2021-06-2536 min
LaBossiere Podcast#11 - Robin HansonProfessor Robin Hanson on hidden motives, emulating brains, and life in the universe.2021-06-1730 min
LaBossiere Podcast#10 - Eli DouradoOn the great stagnation, transformational technologies, and the future of crypto with Eli Dourado.2021-06-1128 min
LaBossiere Podcast#9 - Beth ComstockOn risk, corporate culture and the necessity of conflict with Beth Comstock, author and former CMO and vice chair at General Electric.2021-06-0327 min
LaBossiere Podcast#8 - Annie DukeAnnie Duke on “right” decisions, when to quit, and hedging your bets.2021-06-0135 min
LaBossiere Podcast#7 - Patri FriedmanTalking poker, cities on the ocean, and anarcho capitalism with the founder of The Seasteading Institute.2021-05-2824 min
LaBossiere Podcast# 6 - Troy OsinoffOn starting young, unconventional paths, and the future of marketing with Troy Osinoff, co-founder of Juice, an award winning digital marketing agency.2021-05-2716 min
LaBossiere Podcast#5 - Bradley TuskOn politicians, saving Uber, and mobile voting with Bradley Tusk, a man doing everything at once.2021-05-2028 min
LaBossiere Podcast#4 - Ryan DelkLessons in building, the state of education, and defining success with the CEO of Primer.2021-05-1923 min
LaBossiere Podcast#3 - Mark LutterOn building cities from scratch, good governance, and how we’ll live in 2050 with the Founder and Executive Director of the Charter Cities Institute.2021-05-1432 min
LaBossiere Podcast#2 - Megan SmithTalking personal journey, sustainable development and entrenched biases with the former US CTO and Google VP, now CEO and founder of people-forward innovation company Shift7.2021-05-0638 min
LaBossiere Podcast#1 - Raghuram RajanThe esteemed economist and former Governor of the Reserve Bank of India talks community, COVID, and inequality.2021-05-0330 min
Wanda's Picks8 AM: Ayana Labossiere, teacher, member, Haiti Action Committee is working with Alex Walker, Vagant Poetics, on a Benefit for Haiti--an open mic for activists at Goodbellies Cafe in Oakland; Robert Roth, teacher, is a co-founder of the Haiti Action Committee and a board member of the Haiti Emergency Relief Fund. 8:30 AM: Jovelyn Richards, playwright, Ms. Pat's House, which is opening at La Pena, August 19; she is joined by director Stephanie Johnson. 9 AM: Kevin Epps, filmmaker, joins us to talk about his film, The Black Rock, a film about blacks incarcerated in the USA's first maxium security prison, and his year...2011-08-052h 11
The Peace Revolution PodcastPeace Revolution episode 026: Exposing the Folly of an American Theatre of the Absurd
Peace Revolution episode 026: Exposing the Folly of an American Theatre of the Absurd
Would you like to know more?
Notes, References, and Links for further study:
1. White House video of Obama announcing Osama’s death
2. Good Morning America discovers Osama bin Laden is CIA via Corbett Report
3. Al Qaeda doesn’t exist; courtesy of BBC and Adam Curtis’ film “The Power of Nightmares”
4. ...2011-05-0800 min
The Peace Revolution Podcast (Archive Stream 2006-Present)Peace Revolution episode 026: Exposing the Folly of an American Theatre of the AbsurdPeace Revolution episode 026: Exposing the Folly of an American Theatre of the Absurd
Would you like to know more?
Notes, References, and Links for further study:
1. White House video of Obama announcing Osama’s death
2. Good Morning America discovers Osama bin Laden is CIA via Corbett Report
3. Al Qaeda doesn’t exist; courtesy of BBC and Adam Curtis’ film “The Power of Nightmares”
4. The motives behind 9-11 by Steve Pieczenik via the Alex Jones Show
a. Osama’s connections to CIA, MI6, and MOSSAD; by Stev...2011-05-082h 59