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Astrid Weins

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GN in TenGN in TenBoard Review Bonus #2: Minimal Change DiseaseIn this special bonus episode of the podcast, Koyal and Kenar provide a maximally useful review of minimal change disease, from diagnosis (including secondary causes to screen for) to treatment options, including how to decide which patients may do better with which therapies. Can’t get enough minimal change? Check out Episode 6 (with Astrid Weins) and Episode 7 (with Felicitas Hengel and Nicola Tomas) for more on the potential role of anti-nephrin autoantibodies in MCD.ReferencesKDIGO guidelines: https://kdigo.org/wp-content/uploads/2017/02/KDIGO-GD-Guideline-Key-Takeaways-for-Clinicians-Minimal-Change-Disease.pdfAnt...2024-09-1624 minGN in TenGN in TenEpisode 7: Felicitas Hengel and Nicola Tomas on a New Chapter in Anti-Nephrin AutoantibodiesIn this episode, we talk with Dr. Felicitas Hengel, MD and Dr. Nicola Tomas, MD (both at the University Medical Center Hamburg-Eppendorf) about their groundbreaking anti-nephrin autoantibody research that was just presented at the 2024 ERA Congress and published in the New England Journal of Medicine. Is this a game-changer for minimal change? How could this new understanding change diagnosis and treatment in the future? Are anti-nephrin autoantibodies the next PLA2R? What are the next steps for follow-up studies? And how do you do a big international study like this, anyway? References:The s...2024-06-0616 minGN in TenGN in TenEpisode 6: Astrid Weins on Anti-Nephrin Antibodies and NephropathologyIn this episode, Kenar and Koyal interview Dr. Astrid Weins, MD, PhD, about nephropathology, new approaches to solving the mysteries of nephrotic syndrome, and her research on anti-nephrin antibodies in minimal change disease. Dr. Weins is Chief of Integrated Renal Pathology at Mass General/Brigham and an Assistant Professor of Pathology at Harvard.Interested in this topic? Stay tuned for additional new research on anti-nephrin antibodies that will be presented in a Late-Breaking Clinical Trials session on May 25 at the 2024 ERA Congress.References:2024-05-1717 minFreely Filtered, a NephJC PodcastFreely Filtered, a NephJC PodcastAnti-Nephrin Antibodies Cause Minimal Change Disease. Wait...What?The Filtrate:Joel TopfJennie LinJoshua WaitzmanNayan AroraSophia AmbrusoSpecial Guest:Astrid Weins (@AstridWeins) renal pathologist at the Brigham and Woman’s Hospital and Harvard Medical SchoolEditor:Nayan AuroraShow Notes:Summary of minimal change disease according to the orthodoxy: Light microscopy of renal biopsy specimens from patients with MCD shows minimal to no change; however, electron microscopy reveals the effacement of podocyte foot processes. To add to the conundrum, immunofluorescent staining of biopsy...2022-02-271h 17The Watt From Pedro ShowThe Watt From Pedro Show2021-03-26 The Watt from Pedro Showhour one: john coltrane interview with michiel de ruyter on jul 27 1965 "lifeboat" silver ash (aaron dugan + casey block + jeff arnal) "crickets for magnetic tape" jeff arnal "assorted jellies at pink pond" dustin wong "stridex dealer" tobacco "black and bluegrass" bomis prendin "no force" hans rotten "hard core in my blood" slang "jim on the move" hifiklub w/eugene chadbourne untitled (jamming in miami 2016 part 3) ig and thurst "heart for milford graves" aaron dugan + jason fraticelli + jeff arnal hour two: "deathless" silver ash (aaron dugan + casey block + jeff arnal) "enorme" ben salter "i is for itchy" lucas abela "fifth pail" pail...2021-03-263h 00