Shows
Smart Biotech Scientist | Master Bioprocess CMC Development, Biologics Manufacturing & Scale-up, Cell Culture Innovation182: Innovating Continuous Bioprocessing with Vibrating Membrane Filtration with Jarno Robin - Part 2What if the secret to making continuous bioprocessing practical, sustainable, and far simpler has been shaking - literally - just beneath our feet?For years, the industry has grappled with the complexities of continuous manufacturing, with technologies like ATF (alternating tangential flow) steadily dominating the perfusion landscape. But what if there's a game-changer right around the corner - a technology that vibrates membranes, not workflows, promising both higher performance and a greener footprint?Enter Jarno Robin, a pioneering force in membrane filtration and R&D leader at Sani Membranes. With two decades of experience implementing...
2025-08-2115 minSmart Biotech Scientist | Master Bioprocess CMC Development, Biologics Manufacturing & Scale-up, Cell Culture Innovation181: Innovating Continuous Bioprocessing with Vibrating Membrane Filtration with Jarno Robin - Part 1What if one of biotech’s biggest production breakthroughs was hiding in plain sight? Not in a new gene or a wonder drug, but in the way we process and purify biologics.Perfusion technology, once dismissed as a pipedream in top biopharma boardrooms, is now quietly powering some of the industry’s most efficient and productive manufacturing platforms. Yet, transforming perfusion from controversial buzzword to gold standard required timing, vision, and a willingness to break from tradition.In this episode, host David Brühlmann sits down with Jarno Robin, a bioprocessing pioneer whose 20+ year journey spans...
2025-08-1925 minSmart Biotech Scientist | Master Bioprocess CMC Development, Biologics Manufacturing & Scale-up, Cell Culture Innovation179: How Mesenchymal Stromal Cells Are Transforming Care for Diabetes and Autoimmune Diseases with Lindsay Davies - Part 1The key to conquering autoimmune diseases and type 1 diabetes may lie not in replacing lost cells, but in retraining the immune system using cells already within the body.Biotech is increasingly exploring stem cell therapies, but a quieter revolution is brewing: stromal cell therapy. These master “coordinators” aren’t about rebuilding tissues molecule by molecule - instead, they orchestrate an anti-inflammatory response, offering new hope for conditions once considered incurable.In this episode of the Smart Biotech Scientist Podcast, host David Brühlmann speaks with Lindsay Davies, a leading expert in advanced therapies. She is the CSO...
2025-08-1223 minSmart Biotech Scientist | Master Bioprocess CMC Development, Biologics Manufacturing & Scale-up, Cell Culture Innovation178: Rethinking Cultivated Meat Production: Scale and Media Optimization Strategies Slashing Manufacturing Costs with Richard Alldread - Part 2The promise of cultured food is undeniable: delicious, sustainable meat and fish grown without the need for traditional farming. But the journey from lab bench to supermarket shelf is filled with complex regulatory, technological, and consumer acceptance challenges. The big question: how do we transform small-scale breakthroughs into global food production realities?In this episode of the Smart Biotech Scientist Podcast, host David Brühlmann sits down with Richard Alldread, CTO of The Cultured Hub - a unique joint venture between Givaudan, Bühler, and Migros - positioned at the intersection of flavor, food processing, and retail ex...
2025-08-0720 minSmart Biotech Scientist | Master Bioprocess CMC Development, Biologics Manufacturing & Scale-up, Cell Culture Innovation177: Rethinking Cultivated Meat Production: Scale and Media Optimization Strategies Slashing Manufacturing Costs with Richard Alldread - Part 1What if the secrets to feeding the planet - and democratizing access to future protein - were hiding in the core toolkit of biopharma?The worlds of biopharmaceuticals and cultured food may seem galaxies apart, but at their heart, both rely on remarkably similar technology: media, bioreactors, and cell processing. Yet, as demand grows for sustainable, affordable protein for the masses, innovators are confronting a challenge bigger than scale.This week, host David Brühlmann welcomes Richard Alldread, Chief Technology Officer at The Cultured Hub, a groundbreaking joint venture between three Swiss industry leaders that s...
2025-08-0523 minSmart Biotech Scientist | Master Bioprocess CMC Development, Biologics Manufacturing & Scale-up, Cell Culture Innovation176: How Virtual Reality Training Solves Europe's Bioproduction Talent Shortage with Sandrine Lemoine - Part 2What if the missing link to resilient European bioproduction is not just another breakthrough technology, but the ability to continuously learn, adapt, and collaborate?In a rapidly shifting biotech landscape, innovation isn’t only driven by technical prowess. Behind every robust production process and every cutting-edge therapy, there’s a team empowered with both technical expertise and the soft skills necessary to thrive.In this episode, host David Brühlmann explores the human side of bioproduction with Sandrine Lemoine, CEO of Immerscio.bio, who has dedicated her career to transforming talent development in the industry. Sandr...
2025-07-3114 minSmart Biotech Scientist | Master Bioprocess CMC Development, Biologics Manufacturing & Scale-up, Cell Culture Innovation175: How Virtual Reality Training Solves Europe's Bioproduction Talent Shortage with Sandrine Lemoine - Part 1What if the road to bioproduction mastery started not in the lab, but with how you train your people?Traditional biotech education often ends at theory, leaving graduates unprepared for the fast-paced world of manufacturing. But what if the key to faster, safer, and more scalable bioprocessing is digital immersion, letting scientists train in a virtual facility before they ever enter a real one?This week, David Brühlmann welcomes Sandrine Lemoine, CEO of Immerscio.bio, to the Smart Biotech Scientist Podcast. With over 25 years spanning R&D, manufacturing strategy, and executive coaching, Sandrine has s...
2025-07-2919 minSmart Biotech Scientist | Master Bioprocess CMC Development, Biologics Manufacturing & Scale-up, Cell Culture Innovation174: Mastering Hybrid Model Digital Twins: From Lab Scale to Commercial Bioprocessing with Krist Gernaey - Part 2How do you transform hybrid model digital twins from promising lab concepts into commercial bioprocessing game-changers that actually deliver ROI?As biotech companies race to implement Industry 4.0 technologies, the critical challenge isn't just developing sophisticated hybrid models - it's deploying them strategically to create user-friendly, cost-effective solutions that genuinely accelerate your path to commercial bioprocessing success.In Part 2 of this essential conversation, David Brühlmann continues his deep dive with Krist Gernaey, Professor of Industrial Fermentation Technology at the Technical University of Denmark. Krist reveals the strategic framework for moving beyond digital twin hype to b...
2025-07-2418 minSmart Biotech Scientist | Master Bioprocess CMC Development, Biologics Manufacturing & Scale-up, Cell Culture Innovation173: Mastering Hybrid Model Digital Twins: From Lab Scale to Commercial Bioprocessing with Krist Gernaey - Part 1Are you struggling to bridge the gap between lab-scale models and commercial bioprocessing reality? For many biotech innovators, the promise of digital twins meets harsh industrial constraints - where hybrid models that excel in controlled lab environments must prove themselves in the complexity of large-scale manufacturing.This week on the Smart Biotech Scientist Podcast, host David Brühlmann welcomes Krist Gernaey, Professor of Industrial Fermentation Technology at the Technical University of Denmark. With expertise spanning measurement technology development and two decades pioneering hybrid model digital twins for bioprocess applications, Krist reveals the critical gap between digitalization hype a...
2025-07-2221 minSmart Biotech Scientist | Master Bioprocess CMC Development, Biologics Manufacturing & Scale-up, Cell Culture Innovation172: Reimagining Chromatography for Advanced Therapies: From Diffusion to Convection with Scott Wheelwright - Part 2Downstream processing remains one of the most complex and critical steps in biomanufacturing, especially as new therapeutic modalities like cell and gene therapies push current technologies to their limits. The industry faces ongoing pressure to innovate, reduce costs, and improve efficiency, while still ensuring robust and reliable results.In this practical, energetic episode, host David Brühlmann welcomes Scott Wheelwright, Chairman, CTO and Co-Founder of BioChromatographix International (BCI). With a career spanning continents - Asia, Europe, and North America - Scott's perspective is forged from hands-on manufacturing, technology transfer, and building high-growth companies from scratch. He’s not...
2025-07-1719 minSmart Biotech Scientist | Master Bioprocess CMC Development, Biologics Manufacturing & Scale-up, Cell Culture Innovation171: Reimagining Chromatography for Advanced Therapies: From Diffusion to Convection with Scott Wheelwright - Part 1For decades, chromatographic purification has made use of bead-based diffusion - a reliable but limiting approach, especially as new modalities like gene therapies, mRNA, and viruses push the boundaries of what’s possible. But what if the future of downstream processing lies not in incremental improvement, but in a dramatic reimagining - from slow diffusion to rapid convection?In this episode, David Brühlmann meets Scott Wheelwright, Chairman, CTO and Co-Founder of BioChromatographix International (BCI). Scott brings decades of expertise in biopharmaceutical development and manufacturing. Prior to BCI, he co-founded Biolnno Bioscience, a leading CDMO, and co-founded Inn...
2025-07-1520 minSmart Biotech Scientist | Master Bioprocess CMC Development, Biologics Manufacturing & Scale-up, Cell Culture Innovation170: Why Your DNA Is a Terrible Disease Predictor (And How Multi-Omics Changes Everything) with Mo Jain - Part 2For years, disease diagnosis and treatment have focused on a few biomarkers, overlooking thousands of vital biological signals. Despite biotech advances, most therapies are still based on limited data, missing countless breakthroughs.Multiomics changes that. By analyzing tens of thousands of proteins, metabolites, and lipids, it reveals hidden insights, paving the way for smarter, faster, and more effective medical discoveries.In this must-listen episode, David Brühlmann welcomes Mo Jain, founder and CSO of Sapient, a pioneering force in bringing multiomic platforms out of academia and into the heart of drug development. A physician-scientist by t...
2025-07-1022 minSmart Biotech Scientist | Master Bioprocess CMC Development, Biologics Manufacturing & Scale-up, Cell Culture Innovation169: Why Your DNA Is a Terrible Disease Predictor (And How Multi-Omics Changes Everything) with Mo Jain - Part 1What if the secret to truly personalized precision medicine lies not in your genetic code, but in your zip code?For years, biotech has focused on genomics to explain disease and drug response, but DNA only accounts for a fraction of the story. The real breakthrough? Multi-omics: the large-scale analysis of proteins, metabolites, and lipids, powered by advanced mass spectrometry and AI, offering a fuller picture of human health.In this episode, David Brühlmann meets Mo Jain, founder and CSO of Sapient, a leader in multi-omics analytics. With over two decades of experience across p...
2025-07-0826 minSmart Biotech Scientist | Master Bioprocess CMC Development, Biologics Manufacturing & Scale-up, Cell Culture Innovation168: How Generative AI Is Revolutionizing Biotech Regulatory Compliance with Abhijeet Satwekar - Part 2The promise of generative AI in pharma and biotech is huge, but it's also fraught with complexity, especially when it comes to integrating these systems into highly regulated environments. From monitoring evolving guidelines to balancing operational efficiency and data integrity, the journey from hype to real-world impact is filled with both opportunity and skepticism.In this episode, David Brühlmann sits down with Abhijeet Satwekar, Innovation Manager at Merck Healthcare’s Global Analytical Development. Abhijeet has spent years on the front lines of digital transformation in the biotech sector, and his current mission: implementing generative AI for reg...
2025-07-0326 minSmart Biotech Scientist | Master Bioprocess CMC Development, Biologics Manufacturing & Scale-up, Cell Culture Innovation167: How Generative AI Is Revolutionizing Biotech Regulatory Compliance with Abhijeet Satwekar - Part 1Ever feel like you’re drowning in an ocean of constantly shifting regulatory guidelines? The world of biotech is a whirlwind of evolving standards, making compliance not just a headache, but sometimes the stumbling block between life-changing therapies and the patients who need them. But what if artificial intelligence could turn regulatory chaos into your biggest competitive advantage?In this episode, David Brühlmann sits down with Abhijeet Satwekar, Innovation Manager at Merck KGaA’s Global Analytical Development. Abhijeet shares how he’s pioneering the use of generative AI, not as a hype machine, but as a practic...
2025-07-0113 minSmart Biotech Scientist | Master Bioprocess CMC Development, Biologics Manufacturing & Scale-up, Cell Culture Innovation166: Why Your Funding Pitches Fail Despite Brilliant Science (And How to Fix It) - Part 2Have you ever presented a major scientific breakthrough, only to be met with blank stares and distracted executives? You're not alone. In this episode, David Brühlmann shares how he went from drowning in data to winning an innovation contest, not through better tech, but through the power of scientific storytelling.Many scientists default to methods and data, but as David notes, “it’s like being fluent in a language nobody else in the room speaks.” Without a clear link to human impact, even the most brilliant work can go unnoticed.Key insights from the episode...
2025-06-2617 minSmart Biotech Scientist | Master Bioprocess CMC Development, Biologics Manufacturing & Scale-up, Cell Culture Innovation165: Why Your Funding Pitches Fail Despite Brilliant Science (And How to Fix It) - Part 1Have you ever poured months of research into a brilliant innovation, only to watch executives’ eyes glaze over during your presentation? You’re not alone. In this episode, host David Brühlmann describes a familiar frustration: scientists are trained to perfect data, not to sell ideas. But in today’s fast-paced biotech landscape, even the most groundbreaking technology risks fading into obscurity if it isn’t communicated effectively.Here’s what you’ll learn in this episode:Why Good Science Needs Great Storytelling: David Brühlmann shows that the most funded projects are often the best-commu...
2025-06-2418 minSmart Biotech Scientist | Master Bioprocess CMC Development, Biologics Manufacturing & Scale-up, Cell Culture Innovation164: How Moss Enables Production of Unproducible Protein Therapeutics with Andreas Schaaf - Part 2From lab curiosity to commercial reality. Here's what happens when moss meets the brutal economics of bioprocessing.In Part 1, you've heard the science behind moss-based protein production. Now comes the real test: Can it survive the gauntlet of regulatory scrutiny, cost pressures, and manufacturing scale-up that crushes most biotech innovations?In Part 2 of this groundbreaking conversation, David Brühlmann and Andreas Schaaf, Managing Director and CSO of Eleva, dive into the nuts and bolts of what it actually takes to commercialize a revolutionary production platform. Andreas doesn't just theorize—he's lived through 15+ years of transforming Ele...
2025-06-1919 minSmart Biotech Scientist | Master Bioprocess CMC Development, Biologics Manufacturing & Scale-up, Cell Culture Innovation163: How Moss Enables Production of Unproducible Protein Therapeutics with Andreas Schaaf - Part 1What if the future of "impossible" protein therapeutics is hiding in your backyard?For decades, CHO cells have ruled the biotech kingdom as the undisputed champions of complex protein production. But here's the uncomfortable truth: countless breakthrough therapies are gathering dust on laboratory shelves—not because the science failed, but because traditional hosts can’t produce them.Enter moss. Yes, moss. That humble green organism clinging to rocks and trees might just be the biotech industry's best-kept secret.In this eye-opening episode, David Brühlmann sits down with Andreas Schaaf, Managing Director and CSO o...
2025-06-1725 minSmart Biotech Scientist | Master Bioprocess CMC Development, Biologics Manufacturing & Scale-up, Cell Culture Innovation162: How to Achieve 85%+ Cell Recovery Without DMSO's Toxic Side Effects with Jeffrey Allen - Part 2The world of cell therapy is changing rapidly, with revolutionary advancements in cryopreservation and bioprocessing protocols leading the way. In a recent episode of the Smart Biotech Scientist Podcast, host David Brühlmann sat down with Jeffrey Allen, Chairman and CEO of Evia Bio, to dive deep into the “how” of implementing cutting-edge techniques in the lab and the strategic mindset needed to move therapies from concept to clinic successfully.Jeffrey Allen is a passionate leader with a diverse background in shaping strategy, building high-performing teams, and driving exceptional results across public and private equity-backed organizations. With exten...
2025-06-1215 minSmart Biotech Scientist | Master Bioprocess CMC Development, Biologics Manufacturing & Scale-up, Cell Culture Innovation156: The Hidden Economics of Continuous Processing That Most Biotech Companies OverlookThe world of biologics manufacturing is undergoing a major transformation. Once dominated by traditional batch processes, the industry is now experiencing a marked shift toward continuous bioprocessing.But as companies contemplate this transition, two questions dominate strategic discussions: Will regulators accept continuous manufacturing? And, perhaps more pressingly, Does the business case justify making the switch?In this podcast episode of the Smart Biotech Scientist Podcast, David Brühlmann dives into these pivotal topics - drawing insights from real-world case studies, regulatory updates, and economic analyses.Top three takeaways:Regulators Are On Board: T...
2025-05-2227 minSmart Biotech Scientist | Master Bioprocess CMC Development, Biologics Manufacturing & Scale-up, Cell Culture Innovation155: From Process Bottlenecks to Seamless Production: How Continuous Bioprocessing Changes EverythingIn this episode of the Smart Biotech Scientist Podcast, host David Brühlmann dives into continuous bioprocessing - a major shift in biologics manufacturing that's turning traditional batch processes into streamlined, real-time operations.Imagine running your biologics process non-stop for 30 days, with smart monitoring and smaller, more efficient systems replacing massive reactors. It’s not just possible - it’s already happening across the industry, from Amgen’s 80% smaller facility to Sanofi’s modular "Factory of the Future."David explores how companies - big and small - are increasing productivity, cutting costs, and reducing waste through c...
2025-05-2025 minSmart Biotech Scientist | Master Bioprocess CMC Development, Biologics Manufacturing & Scale-up, Cell Culture Innovation152: Is an Indian CDMO the Right Move for Your Biologics Pipeline? with Abdelaziz Toumi - Part 2Is an Indian CDMO the right move for your biologics CMC development?Pulling back the curtain on what might be your next strategic manufacturing advantage, this episode reveals the hidden capabilities emerging from India that leading biotech companies are racing to access. As supply chain vulnerabilities continue to expose risks in traditional manufacturing models, could the solution lie halfway around the world?Joining us to reveal the inside story is Abdelaziz Toumi, CEO of Lupin Manufacturing Solutions and veteran of global pharma giants like Bayer, Merck and Lonza. With over 20 years in biotech, Abdelaziz brings...
2025-05-0821 minSmart Biotech Scientist | Master Bioprocess CMC Development, Biologics Manufacturing & Scale-up, Cell Culture Innovation151: Is an Indian CDMO the Right Move for Your Biologics Pipeline? with Abdelaziz Toumi - Part 1Is an Indian CDMO the right move for your biologics pipeline?As Western biotech companies seek new strategic advantages, one question keeps surfacing: Is India truly becoming the next biotech manufacturing powerhouse? And what hidden capabilities are emerging that leading companies are racing to access?In this episode of the Smart Biotech Scientist Podcast, Abdelaziz Toumi, CEO of Lupin Manufacturing Solutions and veteran of global pharma giants like Bayer, Merck, and Lonza, joins host David Brühlmann to reveal the inside story on when and why you might want to look beyond traditional Western manufacturing p...
2025-05-0628 minSmart Biotech Scientist | Master Bioprocess CMC Development, Biologics Manufacturing & Scale-up, Cell Culture Innovation150: How to Leverage AI in Media Development Without Sacrificing Process Understanding with Tom Fletcher - Part 2As biotech labs rush to adopt AI tools for cell culture media development, a critical question emerges: Are we creating a generation of scientists who know which buttons to push but not why they're pushing them? The automation trap that once transformed laboratory workflows now threatens to fundamentally alter how we understand the complex dynamics of culture media composition and performance.In this second part of our conversation with Tom Fletcher, R&D Director at Fujifilm Irvine Scientific, host David Brühlmann explores the practical challenges of implementing AI in cell culture media development while preserving the s...
2025-05-0125 minSmart Biotech Scientist | Master Bioprocess CMC Development, Biologics Manufacturing & Scale-up, Cell Culture Innovation149: How to Leverage AI in Media Development Without Sacrificing Process Understanding with Tom Fletcher - Part 1From closely-guarded secrets to complex chemical interactions, cell culture media development has transformed from an afterthought to a critical competitive advantage in modern bioprocessing. But as AI and automation revolutionize the field, are we at risk of gaining speed while losing understanding?In this eye-opening episode of the Smart Biotech Scientist Podcast, host David Brühlmann speaks with Tom Fletcher, R&D Director at Fujifilm Irvine Scientific, who brings over 30 years of experience and a unique perspective on balancing technological innovation with scientific rigor.Key Insights from Their Conversation:The Evolution o...
2025-04-2918 minSmart Biotech Scientist | Master Bioprocess CMC Development, Biologics Manufacturing & Scale-up, Cell Culture Innovation145: Beyond ELISA: The 10-Minute Immunoassay Enabling Real-Time Bioprocess Control with Bruno Oesch - Part 1Tired of waiting overnight for ELISA results? Serial entrepreneur Bruno Oesch reveals how his groundbreaking 10-minute immunoassay technology is eliminating the biggest bottleneck in bioprocessing workflows.From contributing to Nobel Prize-winning prion research to founding Prionics (the first commercial BSE test) and now revolutionizing immunoassays with Elionova, Bruno transforms high-end science into practical solutions that work for everyday labs.Here are three takeaways from this podcast episode:ELISA - The Lab Workhorse That Still Matters: Since the 1970s, ELISA assays have been a cornerstone of bioprocessing and diagnostics. As Bruno Oesch puts...
2025-04-1528 minSmart Biotech Scientist | Master Bioprocess CMC Development, Biologics Manufacturing & Scale-up, Cell Culture Innovation144: The Future of Biotech: Making Biotherapeutics More Accessible FasterImagine a future where every patient can access life-saving therapies and sustainable, high-quality food is within everyone’s reach. In this episode of the Smart Biotech Scientist, David Brühlmann explores how innovative biotech developments are making this vision a reality.Here’s a sneak peek of the breakthroughs covered:AI-Powered Picoliter Scale Testing: Discover how companies like Triple Bar Bio are pushing the boundaries of what's possible with their innovative microfluidic technology that screens individual cells. Their approach enables rapid identification the best cell producers, paving the way for more efficient and precise bio-m...
2025-04-1012 minSmart Biotech Scientist | Master Bioprocess CMC Development, Biologics Manufacturing & Scale-up, Cell Culture Innovation143: Bioprocess Breakthroughs: How Smart Bioprocessing Is Democratizing Life-Saving TreatmentsIn the rapidly evolving world of biotechnology, innovation is not just happening at the molecular level. Industry leaders are making groundbreaking advancements in bioprocessing - a crucial component in making life-saving therapies more accessible and affordable.The journey to affordable therapies starts with the production process itself. In this podcast episode, David Brühlmann sheds light on innovations in bioprocess design that are setting new standards in efficiency and efficacy. At the heart of this transformation is the shift from traditional process formats like fed-batch to continuous process formats, quality by design approaches, and the implementation of b...
2025-04-0815 minSmart Biotech Scientist | Master Bioprocess CMC Development, Biologics Manufacturing & Scale-up, Cell Culture Innovation141: How Microalgae Cuts Antibody Costs by 70% and Redefines Biomanufacturing with Muriel Bardor - Part 1The world of biologics manufacturing is about to be transformed by a breakthrough that slashes antibody production costs by 70%. This revolutionary approach leverages the untapped potential of microalgae to deliver a sustainable, cost-effective solution that could make life-saving therapeutics more accessible than ever before. Enter microalgae, the star of this groundbreaking development.In this episode of the Smart Biotech Scientist, Muriel Bardor, the co-founder, CEO and CSO of Alga Biologics, shared insights into how her team's pioneering work with microalgae could redefine the landscape of immunotherapy.Here are some takeaways from her conversation with David...
2025-04-0126 minSmart Biotech Scientist | Master Bioprocess CMC Development, Biologics Manufacturing & Scale-up, Cell Culture Innovation139: Regulatory Secrets Revealed: Why Your CMC Strategy Could Make or Break Your Biotech Startup with Rivka Zaibel - Part 1In biotherapeutic drug development, the journey from discovery to clinic involves navigating a labyrinth of regulatory requirements and strategic considerations, particularly in Chemistry, Manufacturing, and Control (CMC).In this episode of the Smart Biotech Scientist, host David Brühlmann engaged with Rivka Zaibel, President and Founder of ADRES - Advanced Regulatory Services Ltd. - to demystify the regulatory intricacies of biologics development and provide actionable insights for biotech leaders.With over three decades of experience in the biopharmaceutical industry, Rivka Zaibel highlights that understanding the regulatory landscape is crucial for the success of biologics development.
2025-03-2526 minSmart Biotech Scientist | Master Bioprocess CMC Development, Biologics Manufacturing & Scale-up, Cell Culture Innovation138: Skip 90% of Bioreactor Runs: The In Silico Revolution in Bioprocess Development with Yossi Quint - Part 2In the fast-evolving world of biotechnology, the pursuit of efficiency and faster development has never been more critical. The computational tools and models currently being integrated into bioprocessing present a groundbreaking approach that promises radical shifts in drug development timelines and capabilities.In the second part of our conversation, Yossi Quint, founder and CEO of Ark, shows us that the horizon of bioprocessing is lined with possibilities that could revolutionize biotherapeutics accessibility, cost, and speed in pharmaceutical innovations.Here are three key takeaways you don't want to miss:De-risking with Simulation: Yossi...
2025-03-2020 minSmart Biotech Scientist | Master Bioprocess CMC Development, Biologics Manufacturing & Scale-up, Cell Culture Innovation137: Skip 90% of Bioreactor Runs: The In Silico Revolution in Bioprocess Development with Yossi Quint - Part 1The integration of AI into drug discovery has already led to groundbreaking advancements, uncovering patterns in vast datasets that were previously invisible to human researchers. Now, AI is set to revolutionize bioprocessing as well.In this episode of the Smart Biotech Scientist Podcast, Yossi Quint, founder and CEO of Ark, and David Brühlmann explore how AI and computational tools are reshaping bioprocess development. Yossi envisions a future where 90% of bioreactor experiments could be replaced by in silico simulations, dramatically accelerating time to market and increasing throughput.Key takeaways from the conversation with Y...
2025-03-1821 minSmart Biotech Scientist | Master Bioprocess CMC Development, Biologics Manufacturing & Scale-up, Cell Culture Innovation136: 5 Roadblocks to Affordable Biologics (And How to Overcome Them)Sickle cell disease affects thousands with severe daily pain. While FDA-approved gene therapies exist, their $2.2 million cost per treatment makes them largely inaccessible.In this episode of the Smart Biotech Scientist Podcast, David Brühlmann explores five key challenges facing the bioprocessing industry in making these therapies more accessible:Moving Away from Platform TechnologiesTraditional bioprocessing relies on platform technologies for antibody production. However, new therapies require more flexible, adaptable systems that can accommodate novel modalities.Increased Personalization and Smaller Batch SizesPersonalized medicine, especially a...
2025-03-1313 minSmart Biotech Scientist | Master Bioprocess CMC Development, Biologics Manufacturing & Scale-up, Cell Culture Innovation135: Beyond Breakthroughs: Making Biotherapeutics Affordable for AllIn a world of rapid advancements in medical science and biotechnology, bioprocessing is at the forefront of healthcare innovation. Yet, despite remarkable progress, life-saving biotherapeutics remain out of reach for much of the global population.A staggering 80% of patients worldwide lack access to the biotherapeutics they need. While bioprocessing has made impressive strides, the high cost and slow development of these treatments create significant barriers. Addressing these challenges is critical to making innovative therapies widely available.David Brühlmann is launching a special four-part series based on his keynote at the Amphacademy, exploring bioprocessing’s rev...
2025-03-1112 minSmart Biotech Scientist | Master Bioprocess CMC Development, Biologics Manufacturing & Scale-up, Cell Culture Innovation134: Seamless Seed Trains: Simplify Without Sacrificing Quality with François Carruzzo - Part 2The biotechnology industry is on a transformative path. With emerging technologies and innovative ideas, bioprocessing professionals are poised to revolutionize how therapies are developed and delivered. In this episode of the Smart Biotech Scientist Podcast, host David Brühlmann continues his conversation with François Carruzzo, the CTO of Bioscibex, as they delve into the challenges and opportunities present in the biotech landscape.Bioprocess automation boosts efficiency and scalability in therapeutic production. François Carruzzo explores how automation and sensors simplify processes, cut costs, and enhance reliability - key to making biologics more accessible worldwide.Her...
2025-03-0616 minSmart Biotech Scientist | Master Bioprocess CMC Development, Biologics Manufacturing & Scale-up, Cell Culture Innovation132: Combining AI and Biomanufacturing for Sustainable, Cost-Effective Therapeutics with Reza Farahani - Part 2Artificial Intelligence (AI) is transforming industries worldwide, and biotechnology is no exception. In bioprocess development, AI is proving to be a game-changer, accelerating workflows, optimizing processes, and driving innovation. On the Smart Biotech Scientist Podcast, Reza Farahani, founder and CEO of Catalyze AI, shares his insights on how AI is reshaping biomanufacturing and the future of the industry.As AI continues to integrate into bioprocessing, the role of scientists is evolving. Farahani envisions a future where scientists collaborate with AI to enhance efficiency. One of Catalyze AI’s exciting innovations is an agentic root cause analysis tool, de...
2025-02-2714 minSmart Biotech Scientist | Master Bioprocess CMC Development, Biologics Manufacturing & Scale-up, Cell Culture Innovation131: Combining AI and Biomanufacturing for Sustainable, Cost-Effective Therapeutics with Reza Farahani - Part 1The real-world applications of AI in biomanufacturing are transformative. From reducing drug development timelines to optimizing production yields, AI is making biomanufacturing more efficient and cost-effective. This, in turn, enhances global access to life-saving therapies. As AI continues to evolve, its potential to drive even greater innovations in biologics manufacturing becomes increasingly promising.In the latest episode of the Smart Biotech Scientist Podcast, David Brühlmann speaks with Reza Farahani, founder and CEO of Catalyze AI, about the profound impact of AI on biomanufacturing. They discuss how AI is reshaping drug development, reducing costs, and simplifying complex b...
2025-02-2528 minSmart Biotech Scientist | Master Bioprocess CMC Development, Biologics Manufacturing & Scale-up, Cell Culture Innovation130: Revolutionizing Cell Therapy Manufacturing: Reducing Costs to Reach More Patients with Jason Foster - Part 2The intricacies of tech transfer and the challenges of scaling manufacturing processes are often underestimated in the biotechnology industry. Understanding these complexities is crucial for translating innovative scientific breakthroughs into commercially viable products.In the second part of the conversation with Jason Foster, CEO of Ori Biotech, host David Brühlmann explores the complexities of cell therapy manufacturing. Their discussion highlights key challenges, including tech transfer, scale-out strategies, and the crucial role of commercial strategy alongside scientific excellence.Jason also revealed a groundbreaking approach in the cell therapy space. He detailed how Ori's IRO® platform ca...
2025-02-2020 minSmart Biotech Scientist | Master Bioprocess CMC Development, Biologics Manufacturing & Scale-up, Cell Culture Innovation127: The 7 Hidden Innovation Habits That Top Biotech Scientists Use Daily - Part 1In the fast-paced and highly regulated world of biotech development, maintaining an innovative spirit can sometimes feel like a Herculean task. Between optimizing cell culture processes and navigating strict regulatory requirements, it’s no wonder many scientists feel the weight of daily operations pressing down on their creativity. However, fostering innovation is crucial for breakthroughs in our field.David Brühlmann shares practices that have transformed how scientists approach complex challenges in our field.Here are the first four habits that can reshape your approach to bioprocess development.Cultivate Deep Curiosity: Curiosity is...
2025-02-1115 minSmart Biotech Scientist | Master Bioprocess CMC Development, Biologics Manufacturing & Scale-up, Cell Culture Innovation126: How to Enhance Cell Engineering Using Mechanical Intracellular Delivery with Armon Sharei - Part 2As biotechnology rapidly evolves, cell therapies are emerging as a groundbreaking frontier with the potential to transform medicine. In this episode of the Smart Biotech Scientist Podcast, host David Brühlmann speaks with Armon Sharei, founder and CEO of Portal Bio, about the complexities, challenges, and future of cell therapies.Cell therapies could revolutionize medicine in ways similar to antibiotics and vaccines. However, the current manufacturing process is costly and time-consuming.Armon Sharei envisions a future where point-of-care production makes these therapies more accessible, even at the patient's bedside. This approach could not only benefit d...
2025-02-0620 minSmart Biotech Scientist | Master Bioprocess CMC Development, Biologics Manufacturing & Scale-up, Cell Culture Innovation125: How to Enhance Cell Engineering Using Mechanical Intracellular Delivery with Armon Sharei - Part 1Intracellular delivery is essential for advancing research and clinical applications, yet it presents unique challenges when working with different cell types and biomolecules.In a recent episode of the Smart Biotech Scientist podcast, David Brühlmann spoke with Armon Sharei, the founder and CEO of Portal Bio, about the future of cell therapy, the hurdles of intracellular delivery, and groundbreaking innovations in drug screening.Armon’s journey began at MIT, where his initial focus on chemical engineering evolved into a passion for cell engineering. While exploring innovative methods for introducing materials into cells, he discovered a n...
2025-02-0421 minSmart Biotech Scientist | Master Bioprocess CMC Development, Biologics Manufacturing & Scale-up, Cell Culture Innovation122: The Transformative World of Digital Solutions in Bioprocessing with Simon Wieninger - Part 2In the second part of this conversation on digital solutions in bioprocessing, David Brühlmann and Simon Wieninger, Business Manager Digital Solutions at Eppendorf Group, discuss real-world examples of labs revolutionizing their workflows through smart digitalization. From real-time data monitoring to intercontinental data sharing, Simon highlights the practical benefits and exciting future potential of digital technologies in bioprocessing.Missed Part 1? In the previous episode, Simon Wieninger from Eppendorf Group addressed data silos, cloud technology, and security in biotech. Catch up on that episode before diving into Part 2!Key highlights from the episode:Choosing t...
2025-01-2317 minSmart Biotech Scientist | Master Bioprocess CMC Development, Biologics Manufacturing & Scale-up, Cell Culture Innovation121: The Transformative World of Digital Solutions in Bioprocessing with Simon Wieninger - Part 1Digital transformation is reshaping industries worldwide, and biotech is no exception. With the integration of cloud technologies, AI, and data harmonization, bioprocessing is becoming smarter, more efficient, and more innovative. Catching up with digital revolutions in other sectors, biotech now stands at the threshold of tremendous change.In this episode of the Smart Biotech Scientist Podcast, David Brühlmann sat down with Simon Wieninger, Business Manager Digital Solutions at Eppendorf Group, to discuss the digital revolution sweeping through bioprocessing labs. From bioreactors to data lakes, Simon sheds light on the urgent need for a data-driven approach in b...
2025-01-2124 minSmart Biotech Scientist | Master Bioprocess CMC Development, Biologics Manufacturing & Scale-up, Cell Culture Innovation120: Innovating Protein Purification Using Synthetic Organelles and AI with Haotian Guo - Part 2In the ever-evolving world of biotechnology, the integration of artificial intelligence (AI) and synthetic biology is driving unprecedented advancements. This transformative power was the focus of this podcast episode of the Smart Biotech Scientist, where host David Brühlmann engaged in a thought-provoking conversation with Haotian Guo, CEO and Founder of Ailurus on the role of AI in bioprocessing, the significance of wet lab validation, and the exciting future of programmable biology.The conversation with Haotian Guo sheds light on the profound impact AI is having on the field of biotechnology. AI's role as a "co-pilot" in s...
2025-01-1621 minSmart Biotech Scientist | Master Bioprocess CMC Development, Biologics Manufacturing & Scale-up, Cell Culture Innovation119: Innovating Protein Purification Using Synthetic Organelles and AI with Haotian Guo - Part 1Biotechnology is rapidly evolving as innovation addresses real-world needs. At the cutting edge of this evolution, synthetic biology and AI-driven protein design are revolutionizing our approach to complex processes like protein purification.In this episode of the Smart Biotech Scientist podcast, host David Brühlmann talks with Haotian Guo, CEO and Founder of Ailurus, about the modern advancements in synthetic organelles and their transformative impact on protein purification.Haotian Guo introduces a groundbreaking approach inspired by nature’s processes. Instead of relying solely on chromatography, synthetic biology mimics how organelles in cells, like beta cells pur...
2025-01-1419 minSmart Biotech Scientist | Master Bioprocess CMC Development, Biologics Manufacturing & Scale-up, Cell Culture Innovation115: Revolutionizing Biologics Development with Hyper Throughput Screening and AI with Jeremy Agresti - Part 1Bioprocess development is transforming the biotech industry, driving innovations in life-changing therapies. Success hinges on simplifying complex mechanisms and adopting advanced technologies. By integrating high-throughput screening and artificial intelligence, we can streamline workflows, reduce trial-and-error, and speed up biologics development. Embracing cutting-edge tools empowers scientists to maximize biology's potential, delivering efficient and impactful biotech solutions.In this episode of The Smart Biotech Scientist Podcast, host David Brühlmann explores these transformative methodologies with Jeremy Agresti, CTO and founder of Triplebar.Jeremy highlights the future of bioprocessing at the intersection of high-throughput screening, miniaturization, and AI. W...
2024-12-1719 minSmart Biotech Scientist | Master Bioprocess CMC Development, Biologics Manufacturing & Scale-up, Cell Culture Innovation108: From 1 Billion to 100: How AI is Cracking the Enzyme Discovery Code with David Schönauer - Part 2In this captivating episode, we dive deep into the groundbreaking intersection of artificial intelligence and enzyme engineering with David Schönauer, founder and CEO of Aminoverse.From university lab benches to pioneering AI-driven enzyme discovery, David shares how his startup is transforming the biotech landscape by making enzyme development faster, more predictable, and increasingly efficient.Highlights:Discover how AI is revolutionizing enzyme prediction and design, potentially reducing development time from years to weeksLearn why high-quality wet lab data remains crucial for AI success in biotech, and how Aminoverse's unique approach combines both worldsGain insights i...
2024-11-2127 minSmart Biotech Scientist | Master Bioprocess CMC Development, Biologics Manufacturing & Scale-up, Cell Culture Innovation107: From 1 Billion to 100: How AI is Cracking the Enzyme Discovery Code with David Schönauer - Part 1Ever wondered how scientists find the perfect enzyme among billions of possibilities? In this fascinating episode of the Smart Biotech Scientist podcast, host David Brühlmann sits down with David Schönauer, CEO of Aminoverse, who's revolutionizing enzyme engineering through artificial intelligence.As a biotech entrepreneur who transformed his academic passion into a groundbreaking startup, Schönauer shares how his company is solving one of biotechnology's biggest challenges: efficiently identifying the right enzyme for specific applications, from pharmaceutical manufacturing to sustainable consumer products.Key Takeaways:Discover how Aminoverse's innovative platform navigates through mor...
2024-11-1919 minSmart Biotech Scientist | Master Bioprocess CMC Development, Biologics Manufacturing & Scale-up, Cell Culture Innovation101: PAT Revolution: Decoding Your Bioprocess Like Never Before with Katharina Dahlmann - Part 1Unlock the hidden potential of your bioprocess! In this eye-opening episode, David Brühlmann sits down with Katharina Dahlmann, Application and PAT Expert at Hamilton, to explore the game-changing world of Process Analytical Technology (PAT).Discover how PAT is revolutionizing biotech by providing unprecedented insights into cell behavior and process dynamics. Katharina challenges conventional wisdom, revealing that what we think we know about our processes may just be the tip of the iceberg. Learn how combining multiple PAT signals can extract meaningful knowledge, leading to more reproducible and efficient processes.You will gain valuable insights o...
2024-10-2924 minSmart Biotech Scientist | Master Bioprocess CMC Development, Biologics Manufacturing & Scale-up, Cell Culture Innovation97: The Biomanufacturing Revolution: Bringing Game-changing Products to Market with James Ryall - Part 1In this captivating episode, host David Brühlmann welcomes James Ryall, a strategic consultant with over two decades of experience in cell biology and regenerative medicine. From his groundbreaking work in skeletal muscle research to revolutionizing cultured meat production, James shares his fascinating journey through academia and industry.Discover how he's now helping biotech startups align their technical strategies with commercial outcomes, accelerating their path to market.You will gain invaluable insights on:Navigating the transition from academia to industryScaling cell production from lab quantities to industrial volumesIdentifying and pivoting to the right target m...
2024-10-1525 minSmart Biotech Scientist | Master Bioprocess CMC Development, Biologics Manufacturing & Scale-up, Cell Culture Innovation96: AI in Bioprocess Development: The Game-Changer You Can't Ignore with Belma Alispahic - Part 2Are you ready to revolutionize your bioprocess development? Join David Brühlmann as he interviews Belma Alispahic, Chief Scientific Officer and Co-Founder of AnalysisMode, who unveils the game-changing potential of AI in biopharma.Discover how AI is transforming the industry, from drug discovery to manufacturing, and learn why it's no longer optional but essential for success.Key takeaways:Leverage AI to streamline experiments, reduce costs, and accelerate your path to marketGain insights into emerging AI technologies reshaping biopharma's futureLearn practical steps to integrate AI into your workflow, even with limited resourcesDon't miss t...
2024-10-1019 minSmart Biotech Scientist | Master Bioprocess CMC Development, Biologics Manufacturing & Scale-up, Cell Culture Innovation88: The Swiss Army Knife of Biotech: Unleashing the Power of Fractional ExpertiseUnlock the secret weapon of biotech success! In this eye-opening episode, host David Brühlmann reveals how fractional CTOs are revolutionizing drug development, inspired by Michael Jordan's approach to greatness. Learn how this innovative strategy can slash timelines, mitigate risks, and give your biotech company a competitive edge.Discover the game-changing benefits of fractional expertise:Gain rapid access to broad biotech knowledge, navigating complex challenges with ease.Slash costs while tapping into C-level strategic guidance for critical growth phases.Accelerate business development through valuable industry connections and insights.Ready to transform your biotech journey? Tune i...
2024-09-1216 minSmart Biotech Scientist | Master Bioprocess CMC Development, Biologics Manufacturing & Scale-up, Cell Culture Innovation87: The Hidden Pitfalls of Bioprocess Development: Lessons from the TrenchesUnlock the secrets of successful bioprocess development with host David Brühlmann as he shares hard-won lessons from his 15+ years of experience leading technology transfers and technology innovation projects.Discover why prioritizing process development is crucial for transforming groundbreaking science into life-changing therapies. In this eye-opening episode, you'll learn:How to avoid costly mistakes in technology transfer and scale-up, saving you time and resourcesStrategies for balancing investor expectations with regulatory hurdles, keeping your project on trackTips for building a robust risk management strategy that impresses investors and navigates challengesFrom selecting the right cell lines t...
2024-09-1016 min
Unlock Meaning with David Brühlmann | Find Purpose, Achieve More, Live Your Best Life62: I Quit: Here’s WhyIn this life-changing video, I, David Brühlmann, explain why I've decided to quit Unlock Meaning and what incredible new adventures await. I delve into the importance of focusing on what truly matters, identifying and prioritizing your "big three" goals, and becoming your future self. Discover why making a 10X leap is easier and more rewarding than a 2X one and how living a life of significance can be your reality.This video will help you understand the power of clarity in pursuing your future self and encourage you to eliminate lesser goals that are not in a...
2024-02-2213 minSmart Biotech Scientist | Master Bioprocess CMC Development, Biologics Manufacturing & Scale-up, Cell Culture Innovation22: Unleashing Effective QbD Strategies to Master Cell Therapy with Shin Kawamata - Part 2Are you looking for advanced strategies to enhance the quality and efficiency of cell therapy manufacturing processes?In this episode with Shin Kawamata, CEO of Cyto-Facto Inc., we dive into the transformative power of digitization in cell therapy manufacturing and explore strategies to enhance efficiency and reduce costs.Actionable Takeaways:Initiate Digital Transformation: Take the first step toward transforming your manufacturing processes by incorporating robust data business practices, ensuring a maturation of the cell therapy industry.Leverage AI and Metabolome Sensors: Discover actionable insights into harnessing the power of AI for navigating cell therapy...
2024-01-2518 minSmart Biotech Scientist | Master Bioprocess CMC Development, Biologics Manufacturing & Scale-up, Cell Culture Innovation21: Unleashing Effective QbD Strategies to Master Cell Therapy with Shin Kawamata - Part 1Are the escalating costs and intricate technical hurdles of cell therapy development causing you stress?Tune into this insightful podcast episode featuring Shin Kawamata, CEO of Cyto-Facto Inc. in Kobe, Japan, who shares his expertise and innovative solutions to these pressing issues in the cell therapy industry.Discover how to streamline your manufacturing processes, reduce costs, and enhance product quality, transforming the way you approach cell therapy development.Key Takeaways:Revolutionize Cell Manufacturing: Shin outlines how Cyto-Facto is pioneering a new business model, merging public sector support with commercial viability. Learn how...
2024-01-2322 minUnlock Meaning with David Brühlmann | Find Purpose, Achieve More, Live Your Best Life40: How to Overcome Anxiety: Tips and Techniques for a Peaceful MindDo you feel like anxiety is ruling your life? If you're struggling with anxiety, you're not alone.Anxiety is a common problem that affects millions of people around the world. But the good news is that there are many ways to manage and overcome anxiety.In this episode:You’ll discover ways to overcome anxiety and start living the your best life.We'll also share some helpful Bible verses and insights to help you navigate through difficult times.Whether you're dealing with general anxiety or a specific anxiety disorder, these tips can help you fi...
2023-08-3117 minUnlock Meaning with David Brühlmann | Find Purpose, Achieve More, Live Your Best Life39: Single and Thriving: Why Your Relationship Status Doesn't MatterAre you a Christian single struggling to find your place in a world that often places marriage on a pedestal? Do you feel pressure to settle down and find a partner, but deep down you know that your singleness is a gift from God?Then this episode is for you!We'll explore the purpose of singleness and how it can be used to further God's kingdom.We'll also discuss the dangers of idolizing marriage and the benefits of being single, such as freedom, flexibility, and independence.And, we'll provide practical tips for thriving as a single...
2023-08-2417 minUnlock Meaning with David Brühlmann | Find Purpose, Achieve More, Live Your Best Life38: Making a difference: Tom DeLong’s Mission to Empower Singles through PodcastingJoin us for a fascinating conversation with Tom De Long, founder of the Thriving in Singleness Podcast. Tom shares how surrendering his desire for marriage and embracing his life as a single person has brought him joy and purpose beyond his wildest dreams.Through his podcast, Tom is helping singles worldwide find fulfillment and meaning in their lives, regardless of their relationship status.Don't miss this powerful message of surrender and trust in God's plan for your life. This episode is a must-listen for singles looking for inspiration and guidance in navigating the challenges of...
2023-08-1733 minUnlock Meaning with David Brühlmann | Find Purpose, Achieve More, Live Your Best Life37: Finding Significance and Happiness: The Power of GivingWe all search for happiness in our lives. What if you could find significance and happiness by giving more than you ever thought possible?Tune in to learn more about the power of giving and how it can help you find significance and happiness in your life.►► Unlock happiness: download your free guide → https://unlockmeaning.com/unlockhappiness
2023-08-1011 minUnlock Meaning with David Brühlmann | Find Purpose, Achieve More, Live Your Best Life36: Transforming your Career: How to Unlock your True PotentialAre you tired of feeling stuck and unfulfilled in your job? Do you long to find your passion and purpose in your career? Then this episode is for you!We dive deep into the power of meaningful work and how it can change your life and career for the better.We explore the science behind meaningful work, share practical tips for finding your why.And we provide actionable strategies for unlocking your full potential in the workplace.Let's get started on this exciting journey of transformation and growth!►► Unlock meaning in your life: download your free...
2023-08-0313 minUnlock Meaning with David Brühlmann | Find Purpose, Achieve More, Live Your Best Life35: Unlock Your Potential: 10 Ways to Live Your Best Life NowAre you living your best life? You only get one chance at life. So how do you make sure you're living it to the fullest? In this episode, I explore 10 ways to unlock your potential and live your best life now. No matter who you are or where you're at in life, there's always room for growth and improvement. So tune in and start making changes today!►► Life your best life now and download your free guide → https://unlockmeaning.com/unlockhappiness
2023-07-2717 min
Method To Madness with Mukti MasihHow to thrive as a single? With David Brühlmann Ep 21 [Self-Help]A few years ago, I met this amazing person who was not ashamed or sorry for being single in his late 30s. He challenged me to break some social conventions surrounding my single status. It's so exciting that he agreed to come on my podcast. Listen as David Brühlmann breaks some myths surrounding singleness, how to find a purpose, and thrive as a single.
David's Book links -
Amazon India: https://www.amazon.in/Single-Season-Happy-Christian-Singles-ebook/dp/B0911TP92H/ref=sr_1_3?crid=1FAA9ATJP6I1S&keywords=Single+for+a+season&q...
2023-07-2626 minUnlock Meaning with David Brühlmann | Find Purpose, Achieve More, Live Your Best Life34: From Zero to Almost a Million on TikTok: Rany Mom’s StoryIn this inspiring interview, Rany Mom, an influencer and pastor from Cambodia, shares his incredible journey of going from zero to almost a million followers on TikTok.Discover how Rany leveraged the global pandemic to spread hope, positivity, and the Gospel through his TikTok channel. Despite facing negative comments, Rany remains unwavering in his mission to spread light and love to his followers. His videos offer powerful insights and inspiration to help people stay motivated and hopeful during challenging times. Whether you're looking for encouragement or spiritual guidance, Rany's TikTok account is a must-visit destination....
2023-07-2034 minUnlock Meaning with David Brühlmann | Find Purpose, Achieve More, Live Your Best Life33: Train your brain to see your wins: the GAP and the GAINDo you feel like you're constantly chasing after the next big thing and missing out on true happiness? Most people only focus on what’s lacking and they forget to look at their wins — the GAP and the GAIN. And that's a huge mistake because it means you're not really living your life. You're just enduring it. Learn how to appreciate the small victories in life and find true happiness.In this episode, David Brühlmann will show you how to get your brain to recognize your successes and how to live a happy and fulfilled life. Tune...
2023-07-1312 minUnlock Meaning with David Brühlmann | Find Purpose, Achieve More, Live Your Best Life32: Are You Living for the Right Thing? How to Make Smart ChoicesAre you living for the right thing? Too many of us go through life without a sense of purpose, or worse, we're living for the wrong things. We do them because it's what we're "supposed" to do, or because society tells us that's what will make us happy. But what if there was something more? In this episode, you’ll discover the importance of finding your life's purpose and living with passion and conviction. If you're looking for a life with meaning and purpose, this is a must-listen.►► Unlock meaning in your life: download your free guide → https...
2023-07-0616 minUnlock Meaning with David Brühlmann | Find Purpose, Achieve More, Live Your Best Life31: Reframing Your Career Success through a Christian Worldview with Kevin AnselmoAre you feeling dissatisfied with your career? Are you struggling to define what career success means to you? Well, you're not alone. In fact, many people find it difficult to navigate their careers and often feel unfulfilled despite achieving their goals. That's why I want to invite you to listen to this episode where I chat with communications consultant and author Kevin Anselmo about reframing career success through a Christian worldview. Kevin's book, Reframing Career Success, offers practical advice on how we can find peace and fulfillment in our careers by adopting Christian principles and practices.In...
2023-06-2934 minUnlock Meaning with David Brühlmann | Find Purpose, Achieve More, Live Your Best Life30: Why You Should Put God First in LifeLeave a legacy that will impact generations to come! Join us on an inspiring journey as we uncover the secrets to leaving a lasting legacy. Through deep insights and incredible stories, discover how you can make an eternal impact. Unlocking profound meaning and significance in your life will bring you immense joy and fulfillment.In this episode you'll learn:Why you should put God first in your life, tooHow to find joyTo make your life countTune in!►► Unlock meaning in your life: download your free guide → https://unlockmeaning.com/unlockmeaning
2023-06-2217 minUnlock Meaning with David Brühlmann | Find Purpose, Achieve More, Live Your Best Life29: Focus on What Truly MattersAre you feeling like life is passing you by? That your days slip away without achieving your goals? Imagine if you could refocus, prioritize, and make the most of every single moment. In this episode, you’ll learn how you get more done with radical focus and become more productive with your time. Don't miss out — listen now and start focusing on what truly matters!This episode will enable you to:Unlock the power of focusUnderstand what mattersBoil everything down to the essentialsLearn to Say “No”Remove DistractionsTune in!►► Get Free Access to The 7 Suc...
2023-06-1522 minUnlock Meaning with David Brühlmann | Find Purpose, Achieve More, Live Your Best Life28: Be the Change: How to Make a Difference in the WorldWhat if you could make a real difference in the world? What if you knew exactly what to do, and had all the tools and resources you need? Hint: you can! In this episode, your host, David Brühlmann, shares with you the simple steps you can take to start making a real impact this year. You don't have to wait any longer. You can be the change now.In this episode you'll learn:You can make a real difference because individual action has a powerful impact.How to identify an issue that mattersTo develop tactics f...
2023-06-0813 minUnlock Meaning with David Brühlmann | Find Purpose, Achieve More, Live Your Best Life27: How to Find Meaning in Life: A Purpose-Driven LifeDo you feel lost? Do you not know what your purpose in life is? Are you looking for something more? Watch this episode. In it, your host, David Brühlmann, will share with you how to find meaning in life and live a purpose-driven life.In this episode you'll learn:How to find meaning in LifeThe importance of having a purpose-driven lifeFinding your purpose as a Christian marketplace leaderTune in!►► Unlock meaning in your life: download your free guide → https://mymeaninginlife.com/unlockmeaning
2023-06-0114 minUnlock Meaning with David Brühlmann | Find Purpose, Achieve More, Live Your Best Life26: Unlock Your Dreams: How to Shake off Fear with JJ ViljoenAre you feeling stuck in a cycle of fear and doubt? Uncover the power of your dreams and unlock your potential with JJ Viljoen! In this episode, JJ shares the insights and strategies that have helped her go from feeling scared and overwhelmed to confident and successful. Learn how to shake off the fear and unlock your dreams today!JJ Viljoen is a motivational speaker, musician, minister, and life coach who inspires others to live their best lives.In this episode you'll learn:How to unlock your dreamsWhy you should leave your comfort zoneFinding...
2023-05-2540 minUnlock Meaning with David Brühlmann | Find Purpose, Achieve More, Live Your Best Life25: Find Peace And Happiness In Your Single LifeAre you single and looking for happiness? In this episode, David Brühlmann offers some powerful advice on how to find peace and happiness in your single life. He shares tips on how to create a life that's fulfilling and meaningful, regardless of your relationship status. Whether you're just starting out on your own or have been single for a while, these tips can help you create the life you want!This episode helps you do the following things:Realize it's time to let go of that fear and trust in the plan that God has f...
2023-05-1813 minUnlock Meaning with David Brühlmann | Find Purpose, Achieve More, Live Your Best Life24: The Heartwarming Story of Papa Matt and the Children He Adopted as His Own (with Matt Bohlman)Are you ready for a heartwarming story that will remind you of the power of love and sacrifice? In this episode, we follow the journey of Matt Bohlman, also known as Papa Matt. He arrived in Cambodia for a temporary position overseeing an orphanage. However, as he got to know the children, who had been abandoned by their parents, he found a deep connection and couldn't bring himself to leave.Papa Matt faced many challenges, but his dedication had a profound impact on the lives of the children he adopted as his own. Discover how a higher...
2023-05-1141 minUnlock Meaning with David Brühlmann | Find Purpose, Achieve More, Live Your Best Life23: I Quit and It Paid Off: How Changing My Mindset Allowed Me to SucceedIn this episode, David Brühlmann talks about how he was able to change his mindset and achieve success. After a few tough years of struggling, he finally decided to change the way he was thinking and it made all the difference. Having the right mindset is key to success. You’ll discover how you can change your mindset and achieve anything you want.This episode helps you:Stop your negative thoughts and self-TalkAlign your values with God’sAdopt the right visionTune in!►► Change your mindset. Download your free Unlock Happiness Guide → https://mym...
2023-05-0419 minUnlock Meaning with David Brühlmann | Find Purpose, Achieve More, Live Your Best Life22: Maximize Your Potential: How a 10X Vision Can Help You Achieve Your Goals in 2023When it comes to our dreams, we often play small. We're afraid of what others might think or say about us if we dared to dream big. But what if I told you that the only way to achieve great things in life is by dreaming big? In this episode, David Brühlmann explains why having a 10X vision for your life is so important and how it can help you achieve your biggest goals. So start dreaming big today and see just how much you can accomplish!You'll learn:Why a 10X vision can help y...
2023-04-2717 minUnlock Meaning with David Brühlmann | Find Purpose, Achieve More, Live Your Best Life21: Why You Should Live Your Life With Purpose (according to science)You only have one life. Why not make it a purposeful one? According to science, people who live with purpose are happier and healthier. In this episode, your host, David Brühlmann, discusses the benefits of living your life with purpose and offers some tips on how you can find your own purpose in life. Don’t you want to live a life that matters?In this episode you’ll learn:To live a fulfilled liveTo live healthierTo increase your life satisfactionTune in!►► Live your life with purpose: download your free guide → https://mym...
2023-04-2015 minUnlock Meaning with David Brühlmann | Find Purpose, Achieve More, Live Your Best Life20: Why Most People Never Find Their Passion In Life (And How You Can)Most people never find their passion in life. They give up too easily or get bogged down by distractions and negative thoughts and finally end up in a job they hate because they need to pay their bills. But what if there was another way? What if you could find your passion and make money doing what you love? In this episode, I explore the reason why and offer a solution that can help you find what you're truly meant to do. This is based on the principle of growth mindset — something that's helped me achieve great success....
2023-04-1323 minUnlock Meaning with David Brühlmann | Find Purpose, Achieve More, Live Your Best Life19: The Truth About Missing Out (And Why It's Better Than You Think)When making decisions in life, we're often faced with the fear of missing out. We think that if we don't choose option A, we'll be stuck with option B and miss out on all the good things that come with it. But what if I told you that missing out is actually a good thing? In this episode, David Brühlmann explains why missing out is better than you think and how to make decisions without the fear of regret.In this episode you'll learn:God Gives Us What We NeedUnderstand Why You Are Not Missing O...
2023-04-0620 minUnlock Meaning with David Brühlmann | Find Purpose, Achieve More, Live Your Best Life18: The Truth About Loneliness: How to Overcome it for GoodAre you feeling lonely? Do you feel like you're the only single person that feels this way? You're not alone. Millions of single women and men feel this way, but there are ways to overcome it. In this episode, your host, David Brühlmann, shows you the truth about loneliness and how to overcome it for good. Listen and learn how to break free from the chains of loneliness and start living a happy single life.In this episode you will:Learn to appreciate solitudeRealize that you are not aloneUnderstand that God cares►► Unlock happiness as a...
2023-03-3017 minUnlock Meaning with David Brühlmann | Find Purpose, Achieve More, Live Your Best Life17: Don’t Let These 4 Stupid Myths About Being Single Make Your Life MiserableThere are a lot of myths about being single. But don't let them make your life miserable. In this episode, I talk about four of the most common myths and why they're wrong. Don't you just hate it when people try to tell you what to do? Well, that's how a lot of singles feel about the myths floating around out there about being single. So today, we're going to dispel those stupid myths and remind you why being single can be awesome! You can still have fun and be a happy single – you just need to know how to...
2023-03-2316 minUnlock Meaning with David Brühlmann | Find Purpose, Achieve More, Live Your Best Life16: 4 Surprising Ways to Find Your Purpose and Make It a RealityFinding your life's purpose can be a daunting task. But don't worry, you're not alone. You don't have to do what everyone else is doing. Most people never find out how to live with purpose. You can find your own path in life and make it a reality. In this episode, I share six surprising ways to find your purpose and make it a reality. Whether you're looking for a career change or just want to experience more fulfillment in your life, these tips will help you get started.You'll learn:Discover your purposeBecome what God...
2023-03-1614 minUnlock Meaning with David Brühlmann | Find Purpose, Achieve More, Live Your Best Life15: Live Your Best Life: Discover God as Your Greatest Adventure w/ Bethany AndersonWhat if you could live your best life? What would that look like for you? Join J. Bethany Anderson and David Brühlmann as they discuss discovering God as your most incredible adventure and finding true fulfillment in life. Bethany’s message is one of hope, inspiration, and purpose. She will help you learn how to find meaning and joy every day, no matter what comes your way. The global nomad has followed God into “unknown” places and learned first how to live her best life. She also published a great book called Kiss My Fish. Tune in to start l...
2023-03-0938 minUnlock Meaning with David Brühlmann | Find Purpose, Achieve More, Live Your Best Life14: Healing the Wounds of Past Relationships: The Path to Happiness and PeaceAre you struggling to find happiness and peace after a past relationship? Are you tired of carrying the emotional baggage? This video is for you. In it, I share the path to healing that has helped me find true happiness and peace. Watch now to learn how you can finally let go and move on and become a truly happy single person.In this episode you'll learn:How to get up once again after an “unsuccessful” relationshipHow to let God heal your broken heartHow to find the right kind of supportTune in!►► Unlock h...
2023-03-0219 minUnlock Meaning with David Brühlmann | Find Purpose, Achieve More, Live Your Best Life13: How to Be the Change You Wish to See in the World With Eric LyonsWhat if I told you that you have the power to change the world?In this inspiring and motivating episode, Eric Lyons, founder of Hope for the Silent Voices in Phnom Penh, Cambodia, shows how each and every one of us has the ability to make a difference in the world. Through his own personal story of transformation, he provides powerful tips on how to unleash your inner potential and create real change.His not-for-profit organization brings attention and resources to the severely neglected, disadvantaged, abused and discarded children and teenagers. The world changer calls...
2023-02-2330 minUnlock Meaning with David Brühlmann | Find Purpose, Achieve More, Live Your Best Life12: The Power of Gratitude: How to Use it to Change Your Life at ThanksgivingAre you looking to change your life for the better? One of the best ways to do that is by practicing gratitude. In this episode, David Brühlmann talks about the power of gratitude and how it can change your life for the better. He shares some tips on how to cultivate a grateful attitude and explain why it's so important.In this episode you'll learn:To use a simple gratitude practiceTo overcome challenges to give thanksHow to set you up for enjoyment, satisfaction, and happinessTune in!►► Unlock happiness. Download your free Unloc...
2023-02-1618 minUnlock Meaning with David Brühlmann | Find Purpose, Achieve More, Live Your Best Life11: How to Find Your Life Purpose With Mukti MasihWhat is your life purpose? In this episode, David Brühlmann and Mukti Masih discuss some of the most essential steps to finding your life purpose and offer great insights for anyone struggling to figure out what they’re meant to do with their lives.Mukti Masih discovered how to unlock meaning in any season of her life — as a writer, entrepreneur, in her walk with Christ, and as a seasoned single. So if you’re feeling lost and don’t know what you’re supposed to do with your life, tune in.Mukti Masih, is a top 10...
2023-02-0936 minUnlock Meaning with David Brühlmann | Find Purpose, Achieve More, Live Your Best Life10: How to Survive Valentine's Day When You're SingleValentine's Day is coming up. A day when everyone is supposed to be in love and happy. But what if you're single? Don't worry, I got you.In this episode, David Brühlmann shares five tips on how to survive Valentine's Day when you're single. Whether you're eating ice cream out of the carton or going out with friends, these tips will help make sure your day is fun and enjoyable.So don't stress, relax and watch this video!Key takeaways:Valentine's Day doesn't have to be all about romantic dinners and c...
2023-02-0210 minUnlock Meaning with David Brühlmann | Find Purpose, Achieve More, Live Your Best Life09: The One Thing That Will Make Your Life More Meaningful in 2023What if I told you that there was one thing that you could do to make your life more meaningful?In this episode, David Brühlmann talks about the one thing that will make your life more fulfilling and purposeful and why it's so important. Whether you're looking to find a new career, start a business or simply make some changes in your life, these insights will help get you started on the right path.Key takeaways:Put God FirstSix Reasons Why You Should Put God First To Make Your Life More MeaningfulYou Will F...
2023-01-2619 minUnlock Meaning with David Brühlmann | Find Purpose, Achieve More, Live Your Best Life08: Single? How to Trigger Happiness in Yourself When You're Feeling LonelyAre you feeling lonely? Do you sometimes feel like you’re the only single person in your group of friends?You’re not alone! Let’s face it. It’s tough being single sometimes. But don’t worry, there’s a way to trigger happiness in yourself without relying on someone else!In this episode David Brühlmann share’s four ways to make yourself happy when you’re feeling lonely.You’ll learn how to trigger happiness:Amplify Positive ExperiencesLet Go The Things You Feel LackingPractice GratitudeMake The Present Your FriendLive For Something Great...
2023-01-1913 minUnlock Meaning with David Brühlmann | Find Purpose, Achieve More, Live Your Best Life07: 2023 the Best Year of Your Life - How to Set Goals and Achieve ThemIn this episode, I’m going to talk about the new year, 2023 — the best year of your life. If you want to achieve your biggest dreams, you need to start setting goals today.Setting and achieving goals is one of the most important things you can do for yourself. You’ll learn exactly how to set goals that are achievable and will help you achieve the life you want.In a nutshell, this is how this year will be the best year of your life:Dream bigMake a plan to succeedCelebrate your winsBe patient and pe...
2023-01-1215 minUnlock Meaning with David Brühlmann | Find Purpose, Achieve More, Live Your Best Life06: The Power of Thought: How to Control Your Mind for SuccessWhat if you could control your mind for success? In this episode, David Brühlmann talks about the power of thought and how to control your mind for success.Thought is a powerful tool we often don’t use to our advantage. By learning to control your thoughts, you can achieve anything you want in life! This is a must-listen for anyone looking to improve their life.You’ll learn that…Your thoughts define you.You choose to believe ‘You’re a Victor.’Your thoughts transform you.Only the vision you have of yourself can limit you...
2023-01-0518 minUnlock Meaning with David Brühlmann | Find Purpose, Achieve More, Live Your Best Life05: Living with Intent: How to Find Purpose in Your Life as a Single PersonAre you single and looking for purpose in your life?In this episode, we’ll explore how to find meaning and happiness in your life, even if you’re not in a relationship. We’ll talk about ways to connect with others, engage in meaningful work, and find joy in simple moments.This is how you find meaning and happiness as a single:Make Jesus Your PriorityGive ThanksShare Your Deepest Fears with GodHold on to God’s PromisesConstantly Find Ways to Bless OthersSo if you’re feeling lost or uncertain about the future, tu...
2022-12-2918 minUnlock Meaning with David Brühlmann | Find Purpose, Achieve More, Live Your Best Life04: 4 Powerful Tips for Enjoying your Single Season to the FullestAre you single and looking to enjoy your season?If so, then listen to this episode! I'm going to share with you four powerful tips that will help you make the most of your single season.These tips will help you find happiness, peace, and joy in your life, regardless of your relationship status.In this episode you'll learn:Your season has comeGod wants to use you right nowKnowing it’s for a season makes you gratefulSo if you’re ready to start living a great life as a single pers...
2022-12-2212 minUnlock Meaning with David Brühlmann | Find Purpose, Achieve More, Live Your Best Life01: How to be Happy as a SingleAre you single and looking for ways to be happy?In this episode of Unlock Meaning, your podcast host, David Brühlmann, offers 10 powerful tips to help you find happiness in your singleness. Whether you're just starting out on your own or have been single for a while, these tips on how to be single and happy will help you live a joyful life!In this episode you'll learn:You are in control of your happinessBeing single does not mean you are lonely or aloneThere’s a better way to live: live in the pre...
2022-12-1514 minUnlock Meaning with David Brühlmann | Find Purpose, Achieve More, Live Your Best Life02: How to Thrive as a Single, the Best WayAre you thriving as a single? If not, don't worry!In this episode of Unlock Meaning, your host, David Brühlmann, will give you six tips for thriving in your singleness. There are many benefits to living life as a single, but it's not always easy. Whether you're looking for more love in your life or just want to feel happier and more fulfilled, these tips will help.This is how you thrive in your singleness:Focus on GodTrust GodKnow that God is with youChoose to thrivePrepare your future while waitingMake a differenceT...
2022-12-1523 minUnlock Meaning with David Brühlmann | Find Purpose, Achieve More, Live Your Best Life03: A Higher Purpose: How to Find Meaning in Your LifeHow do you find meaning in your life? How do you find a higher purpose? It's a question that's been asked throughout the ages and is more relevant than ever in today's uncertain world.In this solo episode of Unlock Meaning, your podcast host, David Brühlmann, shares his thoughts on how to find meaning in your life and fulfill your ultimate potential.You will learn how to find your life purpose. In a nutshell:Begin with GodMake an AssessmentDefine the story you want to tell►► Unlock meaning and happiness. Download your free guide...
2022-12-1519 minUnlock Meaning with David Brühlmann | Find Purpose, Achieve More, Live Your Best LifeTrailer Episode-Unlock Meaning with David BrühlmannUnlock Meaning is where you discover how to live an extraordinary life that changes the people around you. David Brühlmann shares faith-based tips, strategies, and mindsets based on his experience as a scientist, executive biotech leader, author, and humanitarian that will help you to live a life of significance. You will learn how you, too, can unlock meaning in every season of your life. He also holds candid conversations with inspirational Christ followers who stopped playing it safe and instead shoot for something bigger to make this world better. Join us on this journey to...
2022-12-0804 min
Your Path to Success with Ruth Kearns WollmannDavid Brühlmann on taking the leap from Corporate Scientist to Humanitarian, Entrepreneur and AuthorDavid Brühlmann is a scientist, a humanitarian and a published author. He left his successful corporate career in the biotech industry nearly 2 years ago to lead an education programme for an NGO in Cambodia. Since then he's gone from strength to strength. Not only has he made a significant impact through ICF Cambodia's education programme (ICF = International Christian Fellowship), but he has also set up his own biotech consultancy and become a published author of a book for Christian Singles called "Single for a Season."
During this interview he shares some of what he...
2021-07-1530 min