Dr. Yamina Berchiche - Podcast Details

Shows

Dr. GPCR Podcast When to Walk, When to Run: Lessons from the GPCR Trenches with Dr. Ben Clements / Dr.GPCR Podcast 166Episode 166 of the Dr. GPCR Podcast features Benjamin Clements, a postdoctoral fellow at the University of Michigan, who brings fresh insight into the therapeutic promise of GPCRs — particularly in the context of opioid pharmacology. With a background in pharmaceutical sciences and neuroscience, Ben now focuses on positive allosteric modulators (PAMs) targeting the mu-opioid receptor, aiming to preserve opioid analgesia while reducing harmful side effects like respiratory depression and addiction.In this episode, Ben and Dr. Yamina Berchiche discuss how a passion for translational science led him to investigate chronic pain models, including neuromas, where opioids traditionally fail. His lab’s pr...

2025-05-1349 min

Dr. GPCR Podcast Finance is Science too with Chuck DeWeese & Joe St. Germain / Dr.GPCR Podcast 165In this episode of the Dr. GPCR Podcast, we step outside the lab to talk about what keeps research-driven organizations running behind the scenes: finance and operations. Yamina Berchiche is joined by Joe St. Germain and Chuck DeWeese from Company Launch Partners to discuss the real-world challenges of building startups and nonprofits—including Dr. GPCR itself. Joe shares his leap from corporate finance to launching a firm that supports early-stage ventures, while Chuck explains his journey from sales to becoming the behind-the-scenes problem-solver for mission-driven organizations.What emerges is a compelling conversation about how science and finance ar...

2025-04-2949 min

Dr. GPCR Podcast The Scientist’s Compass: From Academia to Entrepreneurship with Dr. Dmitry Veprintsev / Dr.GPCR Podcast 163Ask the Right GPCR Question: A Conversation with Prof. Dmitry VeprintsevIn this episode, Yamina sits down with Prof. Dmitry Veprintsev, a molecular pharmacologist at the University of Nottingham, to discuss his scientific journey, GPCR research, and the intersection of academia and entrepreneurship.Watch the video version of this podcast episode:⁠https://www.ecosystem.drgpcr.com/dr-gpcr-podcast/ep-163-with-dr.-dmitry-⁠---------------------------------⁠Become a #DrGPCR Ecosystem Member⁠---------------------------------Imagine a world in which the vast majority of us are healthy.Dr. GPCR is dedicated to foste...

Dr. GPCR Podcast #80 with Dr. Andrew TobinFor more details, visit the #DrGPCR Podcast Episode #80 page https://www.drgpcr.com/episode-80-with-andrew-tobin/ ------------------------------------------- About Dr. Andrew Tobin Andrew Tobin studied Biochemistry at Queen Mary College, the University of London obtaining first-class honors before studying for a D.Phil at the University of Oxford. Following a post-doctoral period at Bristol Myers Squibb in Princeton USA, Andrew returned to the UK to establish his own laboratory at the University of Leicester. Funded through three consecutive Wellcome Trust Senior Research Fellowships Andrew established a reputation in the field of receptor signaling.

2022-06-3053 min

Dr. GPCR Podcast #79 with Dr. Graeme MilliganFor more details, visit the #DrGPCR Podcast Episode #79 page http://www.drgpcr.com/episode-79-with-graeme-milligan/ ------------------------------------------- About Dr. Graeme Milligan Professor Graeme Milligan is Gardiner Professor of Biochemistry, Dean of Research, and Deputy Head of the College of Medical, Veterinary, and Life Sciences at the University of Glasgow. His main research group centers on the function, structure, and regulation of G protein-coupled receptors (GPCRs) and their interacting proteins. His experience also includes translating knowledge generated into the selection of targets, screening, and identification of small molecule regulators of these proteins, and p...

2022-06-2355 min

Dr. GPCR Podcast #78 with Dr. Stuart MaudsleyFor more details, visit the #DrGPCR Podcast Episode #78 page https://www.drgpcr.com/episode-78-with-stuart-maudsley/ ------------------------------------------- About Dr. Stuart Maudsley Stuart graduated from the University of Leeds in the U.K. with a First Class Honors degree in Pharmacology. At the end of his studies, he was awarded the Pfizer Prize for undergraduate research. He then completed his Ph.D. at Leeds as well as the University’s Ackroyd, Brotherton, and Brown Scholar. Following his Ph.D., Dr. Maudsley was awarded a Howard Hughes Medical Institute Fellowship to train wit...

2022-06-161h 37

Dr. GPCR Podcast #77 with Dr. Martin AudetFor more details, visit the #DrGPCR Podcast Episode #77 page https://www.drgpcr.com/episode-77-with-Martin-Audet/ ------------------------------------------- About Dr. Martin Audet Structural biologist, pharmacologist, and a professor of pharmacology at Université de Sherbrooke. He is the head of the AudetLab located at the Institute of Pharmacology of Sherbrooke and is an emerging leader in the structural biology of G Protein-Coupled Receptors and passive transporters. Strong education with a Doctor of Philosophy (Ph.D.) in biochemistry under the supervision of Michel Bouvier at Université de Montréal, followed by a Postdoctoral Fellow at Scr...

2022-06-091h 29

Dr. GPCR Podcast #76 with Steve McCloskeyFor more details, visit the #DrGPCR Podcast Episode #76 page https://www.drgpcr.com/episode-76-with-Steve-McCloskey/ ------------------------------------------- About Steve McCloskey Steve McCloskey is an Alumni from the first class of Nanoengineering at the University of California, San Diego. Steve’s work is focused on emerging technologies applied to Science, Technology, Engineering, and Mathematics (STEM). During his time at UC San Diego Steve worked directly with the founding Chair of the Nanoengineering Department, Ken Vecchio helping set the foundation for the Nanoengineering Materials Research Center and developing thermodynamic processing methods for Iron-based Superelastic al...

2022-06-0253 min

Dr. GPCR Podcast Newsletter - May 2022To read the full #Newsletter click here: https://www.drgpcr.com/May-2022/ ------------------------------------------- Become a #DrGPCR Ecosystem Member ------------------------------------------- Imagine a world in which the vast majority of us are healthy. The #DrGPCR Ecosystem is all about dynamic interactions between us who are working towards exploiting the druggability of #GPCR's. We aspire to provide opportunities to connect, share, form trusting partnerships, grow, and thrive together. To build our #GPCR Ecosystem, we created various enabling outlets. Individuals Organizations ------------------------------------------- Are you a...

2022-05-2703 min

Dr. GPCR Podcast #75 with Vaithish VelazhahanFor more details, visit the #DrGPCR Podcast Episode #75 page https://www.drgpcr.com/episode-75-with-vaithish-velazhahan/ ------------------------------------------- About Vaithish Velazhahan Vaithish obtained dual bachelor’s degrees with honors in Medical Biochemistry and Microbiology from Kansas State University, USA. His undergraduate thesis work on studying the biochemical mechanisms of flavonoids in cancer using nuclear magnetic resonance spectroscopy (NMR) led to a Barry M. Goldwater Scholarship. He then received a prestigious Gates Cambridge Scholarship to study for a Ph.D. at the MRC Laboratory of Molecular Biology and the University of Cambridge, where he is...

2022-05-2652 min

Dr. GPCR Podcast Newsletter - April 2022To read the full #Newsletter click here: https://www.drgpcr.com/April-2022/ ------------------------------------------- Become a #DrGPCR Ecosystem Member ------------------------------------------- Imagine a world in which the vast majority of us are healthy. The #DrGPCR Ecosystem is all about dynamic interactions between us who are working towards exploiting the druggability of #GPCR's. We aspire to provide opportunities to connect, share, form trusting partnerships, grow, and thrive together. To build our #GPCR Ecosystem, we created various enabling outlets. Individuals Organizations ------------------------------------------- Are you a...

2022-05-2103 min

Dr. GPCR Podcast #74 with Dr. Daniel WackerFor more details, visit the #DrGPCR Podcast Episode #74 page http://www.drgpcr.com/episode-74-with-dr-daniel-wacker/ ------------------------------------------- About Dr. Daniel Wacker I obtained my B.Sc. degree from the University of Munich performing work in the lab of Dr. Roland Beckmann with a brief stay at Cambridge University, UK, working in the lab of the late Dr. Kiyoshi Nagai. I then obtained an M.Sc. at the University in Munich working e.g. in the lab of Patrick Cramer. I next moved to Rockefeller University in NYC to work in the lab o...

2022-05-191h 01

Dr. GPCR Podcast #73 with Dr. Aylin HanyalogluFor more details, visit the #DrGPCR Podcast Episode #73 page https://www.drgpcr.com/episode-73-with-dr-aylin-hanyaloglu/ ------------------------------------------- About Dr. Aylin Hanyaloglu Dr. Aylin Hanyaloglu has been a Principal Investigator at Imperial College London since 2007. She received her BSc in Human Biology from King’s College London in 1997, and while her Ph.D. commenced at the MRC Human Reproductive Sciences Centre, Edinburgh, a move to Perth, Australia resulted in her Ph.D. in Molecular Endocrinology being awarded in 2002 with Distinction from the University of Western Australia. Dr. Hanyaloglu undertook her postdoctoral tra...

2022-05-121h 00

Dr. GPCR Podcast #72 with Dr. Stuart MaudsleyFor more details, visit the #DrGPCR Podcast Episode #72 page https://www.drgpcr.com/episode-72-with-stuart-maudsley/ ------------------------------------------- About Dr. Stuart Maudsley Stuart graduated from the University of Leeds in the U.K. with a First Class Honors degree in Pharmacology. At the end of his studies, he was awarded the Pfizer Prize for undergraduate research. He then completed his Ph.D. at Leeds as well as the University’s Ackroyd, Brotherton, and Brown Scholar. Following his Ph.D., Dr. Maudsley was awarded a Howard Hughes Medical Institute Fellowship to train wi...

2022-05-051h 07

Dr. GPCR Podcast #71 with Dr. Jean Martin BeaulieuFor more details, visit the #DrGPCR Podcast Episode #71 page https://www.drgpcr.com/episode-71-with-dr-jean-martin-beaulieu ------------------------------------------- About Dr. Jean Martin Beaulieu Dr. Beaulieu received a Ph.D. in Neurological Sciences from McGill University and completed his post-doctoral training at Duke University. Prior to his recruitment Dr. Beaulieu was an associate professor and Canada Research Chair (Tier2) in the Department of Psychiatry and Neuroscience at Laval University. Dr. Beaulieu’s research is aimed at understanding how cellular and molecular mechanisms regulated by psychoactive drugs intersect with genetic risk factors for me...

2022-04-2818 min

Dr. GPCR Podcast #70 with Dr. Stephen FergusonFor more details, visit the #DrGPCR Podcast Episode #70 page https://www.drgpcr.com/episode-70-with-dr-stephen-ferguson/ ------------------------------------------- About Dr. Stephen Ferguson Dr. Stephen Ferguson is a Professor in the Department of Cellular and Molecular Medicine at the University of Ottawa. He did B.Sc. in biology at McGill University and received his Ph.D. under the mentorship of Dr. Brian Collier in the Department of Pharmacology and Therapeutics at McGill University (1994). He did his postdoctoral training with Dr. Marc G. Caron at Duke University (1994-1997), where he and his colleagues...

2022-04-2152 min

Dr. GPCR Podcast #69 - The History of the Great Lakes GPCR Retreat with Dr. Stephen FergusonFor more details, visit the #DrGPCR Podcast Episode #69 page http://www.drgpcr.com/episode-69-history-of-the-gpcr-retreat-with-dr-stephen-ferguson/ ------------------------------------------- About Dr. Stephen Ferguson Dr. Stephen Ferguson is a Professor in the Department of Cellular and Molecular Medicine at the University of Ottawa. He did B.Sc. in biology at McGill University and received his Ph.D. under the mentorship of Dr. Brian Collier in the Department of Pharmacology and Therapeutics at McGill University (1994). He did his postdoctoral training with Dr. Marc G. Caron at Duke University (1994-1997), where he and his colleagues...

2022-04-1529 min

Dr. GPCR Podcast #68 with Dr. Matthew EddyFor more details, visit #DrGPCR Podcast Episode #68 page https://www.drgpcr.com/episode-68-with-dr-matthew-eddy/ ------------------------------------------- About Dr. Matthew Eddy Matthew Eddy earned his BA in Chemistry from Oberlin College, where he trained with solid-state NMR expert Professor Manish Mehta. He then earned his Ph.D. in physical chemistry from the Massachusetts Institute of Technology, training under the mentorship of Prof. Robert Griffin. Following this, Dr. Eddy began learning and investigating human GPCRs while training in the laboratories of Professors Raymond Stevens and Kurt Wüthrich at The Scripps Research Institute.

2022-04-071h 19

Dr. GPCR Podcast #67 with Dr. Graham LaddsFor more details, visit #DrGPCR Podcast Episode #67 page https://www.drgpcr.com/episode-67-with-graham-ladds/ ------------------------------------------- About Dr. Graham Ladds Graham studied Biochemistry at the University of Birmingham before completing a Ph.D. in yeast pheromone signaling at Warwick. He continued to work at Warwick as a post-doc studying pro-hormone convertases before securing a 5-year independent fellowship funded through the NHS. This project enabled him to return to his interest in GPCRs. He progressed through the ranks at Warwick to become an Associate Professor before leaving in 2015 to join the D...

2022-03-311h 02

Dr. GPCR Podcast #66 with Antony A. Boucard Jr.Dr. Antony A. Boucard Jr. on the web Website LinkedIn Researchgate Loop Academia Pubmed Adhesion GPCR Consortium University of Haiti For more details, visit #DrGPCR Podcast Episode #66 page https://www.drgpcr.com/episode-66-with-antony-a-boucard-jr/ ------------------------------------------- About Dr. Antony A. Boucard Jr. Dr. Antony Boucard joined the Université de Sherbrooke (Québec, Canada) as a B.S. student of the Biochemistry program in 1994 from which he graduated in 1997. It is then that his interest bloomed for the study of GPCRs while joining the group of Dr. Richard Leduc and Dr. Gae...

2022-03-241h 51

Dr. GPCR Podcast #65 with Dr. Sudarshan RajagopalFor more details, visit #DrGPCR Podcast Episode #65 page https://www.drgpcr.com/episode-65-with-sudarshan-rajagopal/ ------------------------------------------- About Dr. Sudarshan Rajagopal Dr. Sudarshan Rajagopal obtained his B.S. in Chemistry from The University of Chicago in 1998. He subsequently enrolled in the Medical Scientist Training Program at The University of Chicago. During his doctoral work in the lab of Prof. Keith Moffat, he studied the structural mechanisms of bacterial photoreceptors using time-resolved Laue crystallography. He was awarded his Ph.D. in 2004 and his MD in 2006. He then joined the Internal Medicine Residency training program a...

2022-03-171h 01

Dr. GPCR Podcast Newsletter - March 2022To read the full #Newsletter click here: https://www.drgpcr.com/march-2022/ ------------------------------------------- Imagine a world in which the vast majority of us are healthy. The #DrGPCR Ecosystem is all about dynamic interactions between us who are working towards exploiting the druggability of #GPCR's. We aspire to provide opportunities to connect, share, form trusting partnerships, grow, and thrive together. To build our #GPCR Ecosystem, we created various enabling outlets. For more details, visit our website http://www.DrGPCR.com/Ecosystem/.

2022-03-1403 min

Dr. GPCR Podcast #64 with Dylan EigerFor more details, visit #DrGPCR Podcast Episode #64 page https://www.drgpcr.com/episode-64-with-dr-dylan-eiger/ ------------------------------------------- About Dylan Eiger Dylan Eiger is currently an MD/Ph.D. student at Duke University School of Medicine. He received his B.S. in Chemistry from Duke University in 2016 where he worked in the lab of Dr. Stephen Craig and studied polymer chemistry and material science. He is currently finishing his Ph.D. in the lab of Dr. Sudarshan Rajagopal, a former postdoctoral fellow of Dr. Robert J. Lefkowitz. Dylan's graduate research focuses on t...

2022-03-101h 01

Dr. GPCR Podcast #63 with Dr. Khaled AbdelrahmanFor more details, visit #DrGPCR Podcast Episode #63 page https://www.drgpcr.com/episode-63-with-dr-khaled-abdelrahman/ ------------------------------------------- Dr. Khaled Abdelrahman graduated in 2006 with a BSc in Pharmaceutical Sciences from Alexandria University (Egypt) followed by MSc in Pharmacology in the same university that was conferred in 2009. He joined the laboratory of Dr. William Cole at the University of Calgary in 2010 for his Ph.D. where he studied the molecular basis underlying altered cerebrovascular function and blood flow in type 2 diabetes. In 2015, He joined Dr. Stephen Ferguson’s laboratory in the Departments of Cellular & Molecular Medicine and Ne...

2022-03-0348 min

Dr. GPCR Podcast Newsletter - February 2022To read the full #Newsletter click here: http://www.drgpcr.com/february-2022/ ------------------------------------------- Imagine a world in which the vast majority of us are healthy. The #DrGPCR Ecosystem is all about dynamic interactions between us who are working towards exploiting the druggability of #GPCR's. We aspire to provide opportunities to connect, share, form trusting partnerships, grow, and thrive together. To build our #GPCR Ecosystem, we created various enabling outlets. For more details, visit our website http://www.DrGPCR.com/Ecosystem/.

2022-02-2803 min

Dr. GPCR Podcast #62 with Dr. Sai Prasad PydiFor more details, visit #DrGPCR Episode #62 page https://www.drgpcr.com/episode-62-with-dr-sai-prasad-pydi/ ------------------------------------------- About Dr. Sai Prasad Pydi Dr. Sai Prasad Pydi obtained his Ph.D. from the University of Manitoba – Canada, where he was introduced to G protein-coupled receptors (GPCRs) by Prof. Prashen Chelikani. His doctoral research focused on the structural and functional characterization of bitter taste receptors (T2Rs). In 2014, Dr. Pydi joined Dr. Jurgen Wess’s lab at the National Institute of Diabetes, Digestive and Kidney Diseases (NIDDK) - NIH, USA as a postdoctoral fellow and trained on unders...

2022-02-1751 min

Dr. GPCR Podcast #61 with Dr. Marta FilizolaFor more details, visit #DrGPCR Podcast Episode #61 page https://www.drgpcr.com/episode-61-with-dr-marta-filizola/ ------------------------------------------- About Dr. Marta Filizola Dr. Marta Filizola is the Sharon & Frederick A. Klingenstein-Nathan G. Kase, MD Professor in the Departments of Pharmacological Sciences, Neuroscience, and Artificial Intelligence and Human Health, as well as the Dean of The Graduate School of Biomedical Sciences at the Icahn School of Medicine at Mount Sinai, in New York, USA. The overall goal of her research program is to obtain rigorous mechanistic insights into the structure, dynamics, and function of important...

2022-02-1049 min

Dr. GPCR Podcast #60 with Dr. Josephine (Pina) CardarelliFor more details, visit #DrGPCR Podcast Episode #60 page https://www.drgpcr.com/episode-60-with-dr-josephine-pina-cardarelli/ ------------------------------------------- About Dr. Josephine (Pina) Cardarelli Dr. Pina Cardarelli, CSO for GPCR Therapeutics Inc., based in South Korea, has recently been named President of GPCR Therapeutics, USA, a newly incorporated Biotechnology company in the Bay Area. The company’s mission is to discover and develop highly effective cancer therapeutics by targeting heteromers of G protein-coupled receptors (GPCR). Burixafor, their most advanced clinical candidate, will be in Phase II clinical trial next year. Additionally, they have a lib...

2022-02-0358 min

Dr. GPCR Podcast Newsletter - January 2022To read the full #Newsletter click here: https://www.drgpcr.com/january-2022/ ------------------------------------------- Imagine a world in which the vast majority of us are healthy. The #DrGPCR Ecosystem is all about dynamic interactions between us who are working towards exploiting the druggability of #GPCR's. We aspire to provide opportunities to connect, share, form trusting partnerships, grow, and thrive together. To build our #GPCR Ecosystem, we created various enabling outlets. For more details, visit our website http://www.DrGPCR.com/Ecosystem/.

2022-01-3102 min

Dr. GPCR Podcast #59 with Dr. Nicola J. SmithFor more details, visit #DrGPCPodcast Episode #59 page https://www.drgpcr.com/episode-59-with-nicola-j-smith/ ------------------------------------------- About Dr. Nicola J. Smith Dr. Nicola J Smith is an expert in molecular pharmacology with a track record in exploring GPCR structure-function relationships in the context of cardiovascular disease and metabolic disorders. She is a National Heart Foundation of Australia Future Leader Fellow and runs a laboratory of 7 Ph.D. and Honours students at UNSW Sydney, where she has recently been promoted to Associate Professor. Most recently, Dr. Smith’s team has made advances...

2022-01-271h 32

Dr. GPCR Podcast #58 with Dr. Juan José FungFor more details, visit #DrGPCRPodcast Episode #58 page https://www.drgpcr.com/episode-58-with-juan-jose-fung/ ------------------------------------------- About Dr. Juan José Fung Dr. Juan José Fung is a Principal Scientist at GPCR Therapeutics, Inc, a drug discovery company focused on targeting GPCR heteromers in cancer, headquartered in Seoul, Korea, with an R&D facility in the SF Bay Area. Dr. Fung received his Ph.D. from the Stanford University School of Medicine under the mentorship of Dr. Brian Kobilka, studying the dimerization of GPCRs. Dr. Fung continued his Postdoctoral training in Dr. Kobilka’s lab c...

2022-01-2154 min

Dr. GPCR Podcast #55 with Mark SchmeizlFor more details, visit #DrGPCR Podcast Episode #55 page https://www.drgpcr.com/episode-55-with-dr-mark-schmeizl/ ------------------------------------------- About Mark Schmeizl Mark leverages 30 years in various life science laboratories & commercial roles with his network of VC & PE contacts to help senior-level life science executives identify new opportunities. He has successfully built numerous global life science, leadership teams, & works closely with both clients & candidates to understand their unique needs & culture. Mark believes professional placement should be about matching talented people with companies where they will thrive, “when the match is right, the results are astonishing.”

2022-01-061h 09

Dr. GPCR Podcast Newsletter - December 2021To read the full #Newsletter click here: https://www.drgpcr.com/december-2021/ ------------------------------------------- Imagine a world in which the vast majority of us are healthy. The #DrGPCR Ecosystem is all about dynamic interactions between us who are working towards exploiting the druggability of #GPCR's. We aspire to provide opportunities to connect, share, form trusting partnerships, grow, and thrive together. To build our #GPCR Ecosystem, we created various enabling outlets. For more details, visit our website http://www.DrGPCR.com/Ecosystem/.

2021-12-3104 min

Dr. GPCR Podcast Newsletter - November 2021To read the full #Newsletter click here: https://www.drgpcr.com/november-2021/ ------------------------------------------- Imagine a world in which the vast majority of us are healthy. The #DrGPCR Ecosystem is all about dynamic interactions between us who are working towards exploiting the druggability of #GPCR's. We aspire to provide opportunities to connect, share, form trusting partnerships, grow, and thrive together. To build our #GPCR Ecosystem, we created various enabling outlets. For more details, visit our website http://www.DrGPCR.com/Ecosystem/.

2021-11-3003 min

Dr. GPCR Podcast #57 with Dr. Peter Robert BanksFor more details, visit #DrGPCR Podcast Episode #57 page: https://www.drgpcr.com/episode-57-with-dr-peter-robert-banks/ ------------------------------------------- About Dr. Peter Robert Banks Peter Banks is currently the Scientific Director at BioTek Instruments, now a part of Agilent. His responsibilities include the management of the company’s applications team and providing scientific guidance to the senior management team on new technology and emerging trends impacting life sciences. Before joining BioTek in 2008, Banks was employed by PerkinElmer for a decade. These roles included management of PerkinElmer’s BioPharma R&D program and Chair of t...

2021-11-2556 min

Dr. GPCR Podcast #56 with Dr. Adriano MarcheseFor more details, visit #DrGPCR Podcast Episode #56 page: http://www.drgpcr.com/episode-56-with-dr-adriano-marchese/ ------------------------------------------- Adriano Marchese is a Professor of Biochemistry at the Medical College of Wisconsin. Adriano received his Bachelor of Science degree in Pharmacology in 1991 from the University of Toronto. He continued his graduate studies at the University of Toronto where he earned his MSc (1994) and Ph.D. (1998) in Pharmacology. He then moved to Thomas Jefferson University in Philadelphia, PA, for his postdoctoral training in Jeff Benovic’s laboratory studying the regulation of G protein-coupled receptor trafficking and signaling. In 2004 Adriano...

2021-11-181h 00

Dr. GPCR Podcast #54 with Dr. JoAnn TrejoAbout Dr. JoAnn Trejo Dr. JoAnn Trejo earned her Ph.D. at UC San Diego. She completed her postdoctoral fellowship at UC San Francisco under the guidance of Professor Shaun Coughlin where she worked on the newly discovered protease-activated GPCRs. Dr. Trejo joined the faculty in the Department of Pharmacology at the University of North Carolina in 2000 and then moved to UC San Diego School Medicine, Department of Pharmacology in 2008, where she quickly rose through the ranks to tenured professor in 2012. In 2014, she was appointed Vice-Chair of the Department of Pharmacology. The long-term goal of Dr...

2021-11-041h 05

Dr. GPCR Podcast Newsletter - October 2021To read the full #Newsletter click here: https://www.drgpcr.com/october-2021/ ------------------------------------------- Imagine a world in which the vast majority of us are healthy. The #DrGPCR Ecosystem is all about dynamic interactions between us who are working towards exploiting the druggability of #GPCR's. We aspire to provide opportunities to connect, share, form trusting partnerships, grow, and thrive together. To build our #GPCR Ecosystem, we created various enabling outlets. For more details, visit our website http://www.DrGPCR.com/Ecosystem/. ------------------------------------------- Are you...

2021-11-0102 min

Dr. GPCR Podcast #53 with Dr. Timo De GroofAbout Dr. Timo De Groof Dr. Timo De Groof studied Biochemistry and Biotechnology at the University of Ghent where he graduated in 2015. During his master's studies, he specialized in Biomedical Biotechnology and Structural Biology/Biochemistry. During his last year of studies, Timo performed research in the biopharmaceutical company Argen x and gained experience in the identification and characterization of llama-derived antibodies in inflammatory diseases and oncology. From 2015 to 2019, he completed his Ph.D. in the Medicinal Chemistry group at VU University Amsterdam under the supervision of prof. dr. Martine Smit. During his Ph.D., Timo, t...

2021-10-2856 min

Dr. GPCR Podcast #52 with Dr. Benjamin MyersAbout Dr. Benjamin Myers Ben Myers is an assistant professor at the University of Utah School of Medicine in Salt Lake City, UT, and an investigator with the Huntsman Cancer Institute. Ben’s research focuses on Smoothened and other class F GPCRs which play essential roles in embryonic development and in cancer. His group studies the unusual signaling mechanisms employed by these atypical 7-transmembrane receptors, combining biochemical and structural approaches with cell biology and in vivo models. These studies have revealed new and unexpected ways for membrane lipids to regulate GPCR activity and for GPCRs to control int...

2021-10-221h 45

Dr. GPCR Podcast #51 with Dr. Mark ConnorUndergraduate BSc with Honours in Pharmacology from University of Sydney (1987, snake neurotoxins), Ph.D. from Department of Pharmacology, University of Washington (1992, mentor Charley Chavkin, sigma receptors). Postdoc with Graeme Henderson (Bristol, opioids and Ca signaling) and Mac Christie (Sydney, opioids in neurons, novel spider toxins). Grant-funded independent research positions from 2001 at University of Sydney (opioids and sensory neurons), Vollum Institute Portland (visiting scientist with Ed McCleskey, sensory neuron properties); Pain Management Research Institute (more opioids, cannabinoids and T-type Ca channels) and Brain and Mind Research Institute (Sydney). 2009, appointed Professor of Pharmacology at Macquarie University. Focus on study of drugs...

2021-10-141h 22

Dr. GPCR Podcast Newsletter - September 2021To read the full #Newsletter click here: https://www.drgpcr.com/september-2021/ ------------------------------------------- Imagine a world in which the vast majority of us are healthy. The #DrGPCR Ecosystem is all about dynamic interactions between us who are working towards exploiting the druggability of #GPCR's. We aspire to provide opportunities to connect, share, form trusting partnerships, grow, and thrive together. To build our #GPCR Ecosystem, we created various enabling outlets. For more details, visit our website http://www.DrGPCR.com/Ecosystem/. ------------------------------------------- Are you a...

2021-09-0704 min

Dr. GPCR Podcast #50 with Dr. Thomas P. SakmarTom Sakmar is a physician-scientist and Rockefeller University professor dedicated to drug discovery and chemical biology research, mainly involving GPCRs. He and his artist/designer wife, Karina Åberg, have three teenage children. ------------------------------------------- Imagine a world in which the vast majority of us are healthy. The #DrGPCR Ecosystem is all about dynamic interactions between us who are working towards exploiting the druggability of #GPCR's. We aspire to provide opportunities to connect, share, form trusting partnerships, grow, and thrive together. To build our #GPCR Ecosystem, we created various enabling o...

2021-09-021h 08

Dr. GPCR Podcast #49 with Dr. Sudha ShenoyAbout Dr. Sudha Shenoy Dr. Sudha Shenoy is currently an Associate Professor in Medicine & Cell Biology in the Division of Cardiovascular Medicine, Duke University Medical Center. She received her Ph.D. from Oklahoma State University and completed her postdoctoral training with Dr. Robert J. Lefkowitz (Nobel Laureate, 2012) at Duke University. Dr. Shenoy’s postdoctoral research discovered that ubiquitination of mammalian G protein-coupled receptors is a tag for lysosomal degradation, whereas ubiquitination of the adaptor protein, β-arrestin, is a tag for receptor internalization and formation of signaling endosomes. Her laboratory has continued to work on identifying the molecular mec...

2021-08-291h 21

Dr. GPCR Podcast #48 with Dr. Nyla Naim, Dr. Michael Lemieux & Dr. Jason Nasse from AddgeneAbout Dr. Nyla Naim Nyla is a Senior Scientist on the Scientific Support Team at Addgene. She received her Ph.D. at the University of Pittsburgh and continued her postdoctoral research at the University of Vermont studying cellular signaling, biosensors, and optogenetics. Nyla supports biomedical research by connecting researchers with resources and promoting reproducible science. About Dr. Michael Lemieux ''My name is Michael (Mike) Lemieux and I am a Connecticut native. I completed my Ph.D. in molecular and cell biology at UConn and then joined Addgene as a Quality Control Scientist in 2015...

2021-08-191h 00

Dr. GPCR Podcast #47 with Dr. Simone Prömel & Dr. Ines LiebscherAbout Dr. Simone Prömel Simone Prömel is currently a professor of cell biology at the Heinrich Heine University Düsseldorf, Germany. Being a biochemist by training, she completed her Ph.D. at the Institute of Biochemistry at the University of Oxford, UK. During this time, she discovered her love for Adhesion GPCRs and started delineating the molecular mechanisms of the Adhesion GPCR Latrophilin-1. These extraordinary receptors, about which there was not much known other than that they are huge and somehow play important roles in health and disease, fascinated her so much that she...

2021-08-071h 13

Dr. GPCR Podcast #46 with Dr. Gunnar SchulteGunnar Schulte is a Professor in receptor pharmacology and research group leader for the section Receptor Biology and Signaling at the Department of Physiology and Pharmacology. He has a background in biochemistry from the Free University in Berlin/Germany and a Ph.D. in molecular pharmacology (supervisor: Bertil B Fredholm; 1998-2002) from Karolinska Institutet. As a postdoc, he trained first with Ernest Arenas (Karolinska Institutet, Molecular Neurobiology; 2003-2005) and later with Roger J Summers (Monash University, Melbourne Australia, GPCR pharmacology; 2006) before starting his independent research team "Receptor Biology & Signalling" in 2008. Gunnar Schulte is also the scientific secretary of the...

2021-07-261h 17

Dr. GPCR Podcast #45 with Dr. Ralf Jockers''Ralf Jockers studied in Cologne and received a Ph.D. in biotechnology and biochemistry from the University of Braunschweig, Germany. For postdoctoral training, he joined the laboratory of Dr. AD Strosberg in France, where he worked on the regulation of ß-adrenergic receptors. He is the Research director at INSERM with a specific interest in G protein-coupled receptors by developing original BRET and TR-FRET assays. His laboratory is currently located at the Institute Cochin – Inserm (Paris, France). He was the director of the French network of GPCRs (GDR-3545), currently directs the International Research Network (IRN) i-GPCRnet of the CNR...

2021-07-1852 min

Dr. GPCR Podcast #44 with Dr. Steven FoordSteve Foord trained as a Physiologist and Pharmacologist and worked for Glaxo through to GSK from 1986 to 2008. He introduced molecular pharmacology to a wide range of the companies GPCR projects and was able to initiate some projects. These included the identification of RAMPs (solving some CGRP family issues) and the GABA B, carboxylic and nicotinic acid receptors. He also discovered and championed a novel prostaglandin EP4 drug candidate to development. He finished his career as Head of Bioinformatics for Neuroscience and working on GSKs novel genetics initiative ------------------------------------------- Imagine a world in...

2021-07-091h 05

Dr. GPCR Podcast #42 with Dr. Randy HallRandy Hall, Ph.D., is a Professor of Pharmacology and Chemical Biology in the Emory University School of Medicine. Randy received his Bachelor's degree in 1990 from the University of New Hampshire and attended graduate school at the University of California at Irvine, studying the regulation of ionotropic glutamate receptors under the direction of Gary Lynch. After obtaining his Ph.D. in 1994, Randy moved to the Vollum Institute in Portland, Oregon, to do a post-doctoral fellowship in the laboratory of Thomas Soderling studying glutamate receptor trafficking and phosphorylation. In 1996, Randy continued his post-doctoral training at Duke University, where he...

2021-07-061h 08

Dr. GPCR Podcast #43 with Dr. Stuart MaudsleyStuart graduated from the University of Leeds in the U.K. with a First Class Honors degree in Pharmacology. At the end of his studies, he was awarded the Pfizer Prize for undergraduate research. He then completed his Ph.D. at Leeds as well as the University’s Ackroyd, Brotherton, and Brown Scholar. Following his Ph.D., Dr. Maudsley was awarded a Howard Hughes Medical Institute Fellowship to train with Professor Robert Lefkowitz at Duke University. Following this tremendous experience, he was recruited to be the Principal Investigator of the Receptor Biology Section at the Medical Research Co...

2021-07-064h 12

Dr. GPCR Podcast #41 with Dr. Terry KenakinAfter obtaining a BSc in chemistry at the University of Alberta in Edmonton Canada, Terry received his Ph.D. in Pharmacology from the University of Alberta, Department of Chemistry, Canada. Dr. Kenakin then moved to the UK, where he did a post-doctoral fellowship in University College London with Sir James Black. His next stop took him to Burroughs-Wellcome (BW) in Research Triangle Park (RTP) in North Carolina USA. After 7 years at BW, Dr. Kenakin joined Glaxo Inc in RTP where he remained for 25 years through iterations of Glaxo Inc, GlaxoWellcome, and finally GlaxoSmithKline. Since 2011, Terry w...

2021-07-061h 18

Dr. GPCR Podcast #40 with Dr. Brian BenderDr. Bender completed his undergraduate studies at Colgate University in upstate New York with a degree in Biochemistry. Between undergraduate and graduate school Brian worked as a technician in an academic lab before moving to Nashville, TN for graduate work at Vanderbilt University where he joined the Department of Pharmacology. Brain’s work there primarily focused on structure prediction of GPCRs from sparse experimental data. He then moved to the University of California in San Francisco to continue his training as a postdoctoral researcher where he used structural models of GPCRs to virtually screen large compound libraries with the go...

2021-06-101h 06

Dr. GPCR Podcast #39 with Dr. Kathryn E LivingstonDr. Kathryn E Livingston is currently a Product Manager at Gator Bio, a biotechnology company providing solutions to researchers studying protein-protein interactions. Kathryn obtained her BS in Chemistry from Carnegie Mellon University and went on to receive a Ph.D. in Pharmacology at the University of Michigan. Working under the supervision of Dr. John Traynor, Kathryn worked to develop and understand first-in-class allosteric modulators of opioid receptors. Research into their mechanism of action in purified systems formed the base of her thesis work. Following this, Kathryn did a post-doctoral fellowship at UCSF in the laboratory of Dr. Mark von...

2021-06-0446 min

Dr. GPCR Podcast #38 with Dr. Alexander S. HauserAlexander is currently a postdoc as a member of the personalized medicine cluster in Copenhagen and at the Institute of Biological Psychiatry in Roskilde working with the UK Biobank and other large-scale population cohorts. Alexander has a big interest in the integration of large biomedical data in genomics, structural biology, pharmacology, and pharmacoepidemiology with innovative computational methods to gain novel insights into receptor biology. During his Ph.D. with David Gloriam at the Department of Drug Design and Pharmacology in Copenhagen, he worked on novel analytical methods to identify human signaling systems and thereby discovered...

2021-05-2857 min

Dr. GPCR Podcast #37 with Dr. Samuel HoareSam completed his Ph.D. in biochemistry, studying allosteric modulation of dopamine receptors, from the University of Kent, United Kingdom. He then moved to the National Institute of Mental Health, researching pharmacological mechanisms of Class B GPCRs as part of his postdoctoral training. Today, Sam is a pharmacology data analyst and the founder of Pharmechanics LLC, a consultancy and data analysis company supporting pharmaceutical, life science, and academic scientists in the development of new therapeutics and the understanding of receptor systems. As an industry pharmacologist, he consults with numerous pharma and biotechs in understanding and applying in...

2021-05-202h 15

Dr. GPCR Podcast #36 with Dr. Michel BouvierMichel Bouvier is a professor of Biochemistry and Molecular Medicine and the CEO of the Institute for Research in Immunology and Cancer (IRIC) at the Université de Montréal. Following his Ph.D. in Neurological Sciences at the same university in 1985, he completed a post-doctoral fellow at Duke University in the laboratory of R.R. Lefkowitz. In 1989, he returned to Montréal as a professor of biochemistry and a scholar of the Medical Research Council of Canada at the Faculty of Medicine of the Université de Montréal. Since 2001, he holds the Canada Research Chair in Si...

2021-05-1245 min

Dr. GPCR Podcast #35 with Dr. Brian Arey - Part 2''Brian Arey is Senior Director of Mechanistic Pharmacology within Leads Discovery and Optimization at Bristol-Myers, Squibb Co. in Lawrenceville, NJ. He obtained both his MS and Ph.D. in Neuroendocrine Physiology at Florida State University before completing his postdoctoral training at Northwestern University. He then moved to work in the pharmaceutical industry where he has held positions of increasing responsibility. He currently leads a team that provides mechanistic understanding of small molecule drug candidates across the entire portfolio of BMS. Brian has contributed to the discovery or development of 5 marketed drugs through his work spanning molecular, biochemical, cellular, and...

2021-05-061h 12

Dr. GPCR Podcast #34 with Dr. Brian Arey - Part 1Brian Arey is Senior Director of Mechanistic Pharmacology within Leads Discovery and Optimization at Bristol-Myers, Squibb Co. in Lawrenceville, NJ. He obtained both his MS and Ph.D. in Neuroendocrine Physiology at Florida State University before completing his postdoctoral training at Northwestern University. He then moved to work in the pharmaceutical industry where he has held positions of increasing responsibility. He currently leads a team that provides a mechanistic understanding of small molecule drug candidates across the entire portfolio of BMS. Brian has contributed to the discovery or development of 5 marketed drugs through his work spanning molecular, biochemical, cellular...

2021-04-281h 06

Dr. GPCR Podcast #33 with Dr. David GloriamDavid Gloriam is a Professor in Computational Receptor Biology at the University of Copenhagen where he leads a research cluster for GPCR function and drug discovery and a Pharmaceutical Data Science unit. His group runs the GPCRdb database where ~4,000 researchers each month retrieve reference data and access online tools for analysis, visualization, and experiment design. Dr. Gloriam is a corresponding member of the Nomenclature Committee of the International Union of Pharmacology (IUPHAR). He is one of the coordinators of recommendations to describe ligand bias towards signaling probes and safer drugs. His group recently developed an online resource...

2021-04-2058 min

Dr. GPCR Podcast #32 with Dr. Chris TateDr. Chris Tate obtained his Ph.D. from the University of Bristol in 1989 and then moved to the University of Cambridge (Dept of Biochemistry) to work on bacterial sugar transporters. In 2005 he started working on the development of conformational thermostabilization of GPCRs, which resulted in the structure of the β1-adrenoceptor. In 2016 mini-G proteins were developed as a tool for the structure determination of GPCRs in the fully active state. Join me to learn more about Chris’s work and his love for science. ------------------------------------------- Imagine a world in which the vast majority of us are hea...

2021-04-141h 03

Dr. GPCR Podcast #31 with Dr. Kevin PflegerDr. Pfleger trained as a pharmacologist and obtained his Ph.D. at the University of Edinburgh. I sat down with Kevin to chat about GPCRs, pharmacology, and his contributions to the field in both the academic and biotech worlds. Professor Pfleger has developed extensive expertise in profiling receptor binding and function at the molecular and cellular levels over the last 20 years, particularly involving GPCRs. He also has globally-recognized expertise in bioluminescence resonance energy transfer (BRET) technology, including his patented Receptor-Heteromer Investigation Technology (Receptor-HIT) for studying heteromers. Kevin is also Director, Biomedical Innovation at The University...

2021-04-0647 min

Dr. GPCR Podcast #30 with Dr. Elva ZhaoElva is currently a research fellow at the Monash Institute of Pharmaceutical Sciences. Elva moved to Canada where she obtained her Ph.D. at the University of Western Ontario, working on the regulation of G proteins signaling by accessory proteins, such as RGS proteins and GPSM proteins. After her Ph.D., she moved to Australia and continues working on GPCRs. Her current research focuses on class B GPCRs and understanding how GPCR signaling and function is mediated by various ligands, binding partners, and intracellular machinery. In her spare time, Elva likes to run in the mountains, play with Tilly...

2021-03-241h 04

Dr. GPCR Podcast #29 with Eleonora ComeoEleonora Comeo is a doctoral candidate in Medicinal Chemistry and Drug Discovery in the joint program of the University of Nottingham in the UK and Monash University in Australia. We sat down to chat about GPCRs, synthesizing labeled ligands, and her unique position that allows her to work with GPCR scientists on 2 continents. We also touched on how COVID-19 affected her Ph.D. work.

2021-03-1757 min

Dr. GPCR Podcast #28 with Dr. Ross Cheloha''Dr. Ross Cheloha is an Investigator at the National Institutes of Health in the Laboratory of Bioorganic Chemistry in Bethesda, MD, where he started in October 2020. He completed his postdoctoral training at MIT and Harvard Med School in the lab of Hidde Ploegh where he developed new applications of single domain antibodies (nanobodies). He earned his PhD in Chemistry at the University of Wisconsin-Madison in the lab of Sam Gellman on the study of analogs of the GPCR peptide ligand parathyroid hormone. Work in his independent laboratory is focused on developing new pharmacological tools via chemistry and protein engineering...

2021-03-0954 min

Dr. GPCR Podcast #27 with Dr. Robert J. LefkowitzIt was December 14th, 2020, 1:50 pm, when I turned on my laptop and signed into Zoom for my chat with Bob. Bob, who, you might ask? Well, it’s the one and only Robert J. Lefkowitz, M.D., 2012 Nobel Prize in Chemistry, which he shared with Dr. Brian Kobilka. Bob doesn’t really need an introduction since his reputation precedes him. Before we pressed record, I asked if I could call him Bob, and he answered that only his mom used to call him Robert, especially when she was upset with him. I then pressed record, and...

2021-02-011h 40

Dr. GPCR Podcast #26 with Dr. Debbie HayDr. Debbie Hay is presently a professor at the Department of Pharmacology and Toxicology at the University of Otago after spending 18 years at the University of Auckland. Her work is primarily focused on class B GPCRs and their interactions with RAMPs. Debbie obtained a Ph.D. in Molecular Pharmacology from Imperial College London in the UK. She has gained experience from working in academia and at GSK as an industrial trainee. Join me and learn more about Debbie’s career and what she learned through her experiences as a scientist.

2021-01-0139 min

Dr. GPCR Podcast #25 with Dr. Annette GilchristOriginally, Annette wanted to be a medical doctor but as luck has it, she didn’t get into medical school when she first applied. Instead, she discovered research and started her Ph.D. the day she should have started medical school. Dr. Gilchrist completed her Ph.D. in Biomedical Sciences / Immunology at the University of Connecticut and went on to become a postdoctoral fellow at UIC (University of Illinois at Chicago). Annette worked in industry, academia and her entrepreneurial side led her to three companies, Cue Biotech, Caden Biosciences, and MyGenomeRx in addition to being a consultant for over a d...

2021-01-011h 02

Dr. GPCR Podcast #24 Bitter or sweet, that is the questionDr. Niv is currently an associate professor and vice dean for research at the Hebrew University of Jerusalem. The Niv lab is also part of the Global Consortium for Chemosensory Research. Masha earned her Bachelor’s degree in chemistry, followed by a direct Ph.D. at the Institute of Chemistry, at The Hebrew University of Jerusalem in Israel. Dr. Niv trained as a postdoctoral fellow at Weill Cornell Medical College. Her work focuses on both sweet and bitter taste receptor GPCRs and her lab established the BitterDB.

2020-12-2758 min

Dr. GPCR Podcast #23 Deep dive into class C GPCRsDr. Fan is currently an associate professor of Pharmacology and Pathology and Cell Biology at Columbia University in NYC. Qing is a structural biologist interested in the molecular mechanisms controlling how class C GPCRs transmit signals. She obtained her bachelor's, master and doctoral degrees at Harvard University and completed her postdoctoral training with Dr. Hendrickson at Columbia University. Join us and learn more about Qing's work and how we powered through a technical issue during the interview.

2020-12-2334 min

Dr. GPCR Podcast #22 Addiction, GPCRs and Brain CircuitsDr. Kari Johnson is currently an assistant professor at the Uniformed Services University of the Health Sciences in Bethesda, Maryland. She is a neuropharmacologist with an interest in the long-term effects of alcohol abuse on neural circuits. Kari completed her Ph.D. in Pharmacology at Vanderbilt University before continuing her training as a postdoctoral fellow at the Vanderbilt Center for Neuroscience Drug Discovery, the National Institute of General Medical Sciences, and the National Institute on Alcohol Abuse and Alcoholism. All through her career, the recurring theme in Kari’s work has been GPCRs and more specifically Metabotropic Glutamate Receptors. Joi...

2020-12-2145 min

Dr. GPCR Podcast #21 How a zoologist turned into an industry GPCR leaderDr. Maria Waldhoer is originally from Austria. She earned her M.Sc. in Zoology and Neurobiology before completing a Ph.D. in Biology and Pharmacology at the University of Vienna. GPCRs led Maria to Thue W. Schwartz’s lab in Copenhagen where she completed her postdoctoral training. After working in the US and at the University in Graz in Austria, Maria worked several years at Novo Nordisk before joining InterAx Biotech in Switzerland as their Chief Scientific Officer. Even though Maria stumbled upon the GPCR field, her 20 years in both academia and in the industry working on GPCRs make he...

2020-12-191h 04

Dr. GPCR Podcast #20 The role of olfactory receptors in the kidneyDr. Pluznick discovered that olfactory receptors in mice are also expressed in their kidneys and blood vessels. Her research is focused on the role of chemosensory GPCRs in regulating renal and cardiovascular function, and identifying renal/cardiovascular olfactory receptor ligands, and relating them to whole-animal physiology. This work contributes to a better understanding of how the kidney helps maintain homeostasis in humans. Jennifer is currently an assistant professor of physiology at the Johns Hopkins School of Medicine. She received her undergraduate degree in biology from Truman State University and earned her Ph.D. in renal physiology from...

2020-12-1446 min

Dr. GPCR Podcast Episode #19 From a lecture on adrenaline function to becoming a successful industry leaderFiona Marshall got fascinated with GPCRs after attending a lecture on how the beta-adrenergic receptor in the heart is activated by adrenaline, during her undergraduate studies at Bath University. She then pursued her Ph.D. in neuroscience from Cambridge University. An expert in GPCR biology, Fiona published the first description of the cloning and structural requirements of the GABAB receptor. One of her career path defining moments came from when she visited Dr. Chris Tate and Dr. Richard Henderson at the Laboratory of Molecular Biology in Cambridge, UK. As a co-founder of Heptares Therapeutics, now called Sosei Heptares, a...

2020-12-0847 min

Dr. GPCR Podcast Episode #18 A.I & GPCR Research - A roundtable discussionListen to this fantastic round table discussion that I had the privilege to moderate with Alexander Hauser. Our guests were Maria Waldhoer, Tudor I. Oprea , Thomas Sakmar, Aurelien Rizk & Yaroslav Nikolaev. The explosion of biomedical data such as in genomics, structural biology, and pharmacology can provide new opportunities to improve our understanding of human physiology and disease. In recent years, machine learning (ML) and artificial intelligence (AI) methods have received a significant boost of attention. ML/AI can be powerful for identifying abstract patterns within large data where traditional methods would be oblivious to. This comes without...

2020-11-171h 00

Dr. GPCR Podcast Episode #17 Dr. GPCR: Beyond the LabGPCRs have played a central role in my scientific career ever since I took Dr. Michel Bouvier’s class as an undergraduate student at the University of Montreal in early 2000. During the past 2 decades, my research mainly focused on chemokine receptor structure/function relationships. For the purposes of this presentation, I will walk you through my various career experiences and include the skills I learned during each experience, which ultimately led me to found Dr.GPCR. Last, I will give an overview of the various programs we established at DR.GPCR, present our team as well as provide you wi...

2020-11-1751 min

Dr. GPCR Podcast Episode #16 GPCR antibody libraries with a TwistIn this episode of the Dr. GPCR Podcast, I spoke to Dr. Aaron Sato from Twist Biopharma, a vertical within Twist Bioscience. Aaron is currently the Chief Scientific Officer and VP of Protein Engineering. He earned his Ph.D. at the Massachusetts Institute of Technology where he studied MHC class II structure-function relationships. His path led him to work in an industry where he assumed various responsibilities and roles in the antibody space. Aaron has a proven track record as a biologics leader as he led teams to discover and develop novel first-in-class antibody therapeutics. Dr. Sato published over 30...

2020-10-2829 min

Dr. GPCR Podcast Episode #15 How two isoforms of beta-arrestin can regulate the function of GPCRs?In this episode of the Dr.GPCR podcast, my guest is Dr. Arun Shukla from the Indian Institute of Technology in Kanpur, India. Arun is currently an Associate Professor & Joy Gill Chair Professor, Intermediate Fellow, Wellcome Trust DBT India Alliance Swarnajayanti Fellow & EMBO Young Investigator at the Department of Biological Sciences and Bioengineering. He earned his master's degree in biotechnology from Jawaharlal Nehru University in India and it was during a biochemistry class where he learned about cell signaling that he became curious and wanted to learn more about it. Arun first started working on GPCRs and...

2020-10-2757 min

Dr. GPCR Podcast Episode #14 Creating better psychiatric medicationsDr. Bryan Roth is the Michael Hooker Distinguished Professor of Pharmacology at the University of North Carolina Chapel Hill School of Medicine. After receiving his MD and Ph.D. in Biochemistry from St. Louis University in 1983, he subsequently trained in pharmacology (NIH), molecular biology, and psychiatry at Stanford. Bryan leads a $26.9 Million project to create better psychiatric medications among other things. But, it wasn’t always this way. Bryan got fascinated with receptors after attending the lecture of a visiting professor on neurotransmission while in college in Montana, where he is from. He was determined to work on...

2020-10-211h 13

Dr. GPCR Podcast Episode #13 Migraine and the promising role of DOR as a therapeutic target for headache with Dr. Amynah PradhanIn this episode of the Dr. GPCR podcast, we meet with Dr. Amynah Pradhan. She is an Associate Professor of Psychiatry at the University of Illinois at Chicago. Amynah did her undergrad research measuring IP3 in airway smooth muscle cells and completed a Ph.D. at McGill University in Canada with Dr. Paul Clarck where she studied opioid receptors. Her next career step took her to AstraZeneca as a postdoctoral trainee where she studies animal models of pain and sensory neuron sensitive-receptor. She then moved back to academia and worked on opioids as a postdoctoral trainee with Dr. Brigitte...

2020-10-081h 09

Dr. GPCR Podcast Episode #12 Using computational pharmacology to understand chemosensory GPCR function with Dr. Antonella Di PizioIn this episode of the Dr. GPCR podcast, we meet with Dr. Antonella Di Pizio, an independent research group leader at the Leibniz-Institute for Food Systems Biology at the Technical University of Munich. Antonella trained as a medicinal chemist in Italy, which she followed up by a Ph.D. in computational medicinal chemistry, during which she developed a taste for structural biology. Antonella then moved to Israel, where she first started working on bitter taste GPCRs in Dr. Masha Niv's lab. Today, Antonella has expanded her research to olfactory GPCRs and trace amine receptors. Join us to learn more...

2020-09-291h 09

Dr. GPCR Podcast Episode #11 Genemod: making research efficient and reproducibleIn this special episode of the Dr.GPCR podcast, I sat down with the co-founders of Genemod. Jacob Lee and Jin Choe met in ninth grade in English class and have been friends since. Although both went to the same college, Jacob and Jin choose different career paths. One day as they were catching up, Jacob shared his struggles of managing samples and an incredible amount of data and projects in the lab with Jin. Our of this need Genemod was born. Today, Genemod has built a freezer management tool and a project management tool where scientists can manage...

2020-09-1628 min

Dr. GPCR Podcast Episode #10 Novel signaling regulators of opioid receptors with Dr. John StreicherOur guest in this episode of the Dr.GPCR podcast is Dr. John Streicher from the department of pharmacology at the University of Arizona. John started grad school in 1999 and spent some time figuring out what he was interested in. It turns out that it was signal transduction and he worked on the signaling cascades involved in heart failure. His encounter and interest in signaling in the context of GPCRs during his postdoctoral training in Dr. Laura Bohn’s lab at Scripps Research Institute in Florida. Today, John and his team focus on understanding how signal transduction cascades downstream of...

2020-09-121h 09

Dr. GPCR Podcast Episode #9 Exploring your career optionsIn this special Dr. GPCR podcast episode, we sat down to chat with Lauren Celano to talk about career options for Ph.D.’s. Working in a lab allows scientists to gain amazing hard and soft skills, which opens the doors to a number of great careers, that many have not even considered, yet. Lauren has a science background and is passionate about helping talented scientists find their dream position. She is also a speaker, connector, recruiter, and coach.

2020-09-0335 min

Dr. GPCR Podcast Episode #8 R&D in the Time of Covid-19 with Dr. Graciela PineyroDr. Graciela Pineyro is a professor of pharmacology at the department of pharmacology and physiology of the University of Montreal. She has done extensive work on the molecular pharmacology of opioid receptors and is currently focusing on the pharmacology of cannabinoids in the context of pain. We chatted about how the current pandemic has affected her personally and professionally.

2020-08-2306 min

Dr. GPCR Podcast Episode #7 Armchair science in the time of Covid-19 with Dr. Paul InselDr. Paul Insel is currently a Distinguished Professor of Pharmacology and the University of California San Diego. Paul thinks broadly about science and has been actively publishing papers about his ideas on how COVID symptoms could be treated while we wait for a vaccine, particularly about ACE2 and angiotensin. For the past 30 years, he has been the Director of MD/Ph.D. training program at UCSD and has served as Editor or Senior Editor of numerous scientific journals, including but not limited to the Journal of Clinical Investigation, Molecular Pharmacology, British Journal of Pharmacology, and American Journal of Physiology-Cell...

2020-08-2340 min

Dr. GPCR Podcast Episode #6 R&D in the Time of Covid-19 with Dr. J. Silvio GutkindDr. J. Silvio Gutkind sheds light on his work and life since the beginning of COVID restrictions. Dr. J. Silvio Gutkind is a Professor of Pharmacology based at UCSD School of Medicine. A large component of his work is centered around dysregulated signaling in cancer and the development of novel mechanism-based cancer therapies. In this episode, Dr. J. Silvio Gutkind highlights how his past experience proves useful in current COVID times and potential benefits the changes in work environments can do for future collaborations.

2020-08-2215 min

Dr. GPCR Podcast Episode #5 R&D in the Time of Covid-19 with Dr. Terry HébertDr. Terry Hébert is a Professor within the Department of Pharmacology & Therapeutics at McGill University. Much of his work is based around GPCR signaling in context to cardiovascular diseases. In this special episode of the Dr.GPCR podcast, we re-connected with Dr.Terry Hebert to chat about how he and his team has been adapting to the new reality of working remotely. Terry tells us about the importance of adapting, communication, and being mindful of those around us.

2020-08-2212 min

Dr. GPCR Podcast Episode #4 Not everything is Black and White: G-proteins vs β-arrestinsDr. Graciela Pineyro’s love for GPCR pharmacology started in Uruguay where she first worked on the serotonin receptors. This interest in research and pharmacology took Graciela to Canada where she stayed ever since she arrived for her Ph.D. work. Graciela has done extensive work on the molecular pharmacology of opioid receptors, exploring their signaling, trafficking, and their ability to activate different signaling pathways and signaling bias. Today, Graciela and her team’s efforts are directed towards the characterization of the pharmacological properties of cannabinoids in conjunction with terpenes for pain relief.

2020-07-2153 min

Dr. GPCR Podcast Episode #3 GPCR signaling in cancer with Dr. J. Silvio GutkindHave you had moments that defined your scientific tastes? For Dr. J Silvio Gutkind, a class on oncogenes and his interests for GPCRs helped shape his scientific interests. These took him from the University of Buenos Aires in Argentina to UC San Diego and through the National Institutes of Health in Bethesda, Maryland. In this episode, Silvio discusses G protein signaling in the context of cancer, immunotherapies, and combination therapies that could help improve patients’ lives.

2020-07-021h 01

Dr. GPCR Podcast Episode #2 How cellular background and localization influence GPCR functionDr. Terry Hebert wanted to be a microbiologist. Instead, he ended up getting interested in membrane protein as he followed the biology of a bacterial toxin that affects a mammalian ion channel. Today he and his team are working on understanding receptor signaling in specialized cellular environments to gain a better grasp of receptor function in pathophysiological settings with a special interest in the cardiovascular system. His favorite GPCR is the angiotensin 1 receptor especially for its ability to activate a large variety of signaling pathways. Terry is also very active on social media. With over 2000 followers on Facebook and...

2020-06-1735 min

Dr. GPCR Podcast Episode #1 How thinking broadly leads to significant scientific discoveriesIn 1975, Dr. Paul Insel was at the FASEB experimental biology meeting in Atlantic City. During dinner with colleagues and Alfred Gillman, co-recipient of the 1994 Nobel Prize in Physiology or Medicine for their discovery of G-proteins and their role in signal transduction in cells, Paul was designated to go to Gillman’s lab. That summer, he used radioligand binding methods to dissect receptor function from the adenylyl cyclase activated by ligands, including adrenaline. From that point on, Paul was hooked and has since studied receptor function in human physiology, receptor molecular pharmacology in cells, and animal models, and as he pu...

2020-06-0253 min

Dr. GPCR Podcast Episode #0 Dr. GPCR PodcastIn this Episode 0 of the podcast, I, Dr. Yamina Bechiche, your host, and founder of DrGPCR introduce you to the very first podcast dedicated to GPCR researchers and their work. This podcast is part of the Dr. GPCR Ecosystem. The goal is to bring us together GPCR scientists, biotech, and pharma leaders as well as suppliers working on GPCRs. We want to provide opportunities to connect, share, form trusting partnerships, grow, and thrive together to accelerate GPCR drug discovery and improve human health. For more information visit us at DrGPCR.com/Podcast and join the DrGPCR Ecosystem at...

2020-05-1204 min