Shows
Evidence-Based GI: An ACG Publication and PodcastA PPI a Day Keeps the GI Bleed Away in the ICUPhilip Schoenfeld, MD, MSEd, MSc (Epi) and Philip Okafor, MD, MPH discuss “Stress ulcer prophylaxis during invasive mechanical ventilation,” by Cook D, Deane A, Lauzier F, et al. NEJM. 2024 July 4; 391(1):9-20.2024-10-2312 min
Med Career MattersInterview with Plastic Surgeon Dr. Philip SchoenfeldDr. Tania Heller has a conversation with Dr. Philip Schoenfeld, a double board-certified facial plastic and reconstructive surgeon, about his path to medicine and his fascinating career.The content of the podcast is for general informational purposes and is not intended as medical advice.2024-08-2034 minMed Career MattersInterview with Plastic Surgeon Dr. Philip SchoenfeldDr. Tania Heller has a conversation with Dr. Philip Schoenfeld, a double board-certified facial plastic and reconstructive surgeon, about his path to medicine and his fascinating career.The content of the podcast is for general informational purposes and is not intended as medical advice.2024-08-1934 minEvidence-Based GI: An ACG Publication and PodcastStemming the Tide: Is Long-acting, IM Octreotide Injection Better than Standard of Care for Angiodysplasia-related GI Bleeding?Philip Schoenfeld, MD, MSEd, MSc (Epi) and Philip Okafor, MD, MPH discuss “Standard of care versus octreotide in angiodysplasia-related bleeding: a multicenter randomized control trial,” by Goltstein L, Grooteman KV, Bernts LH et al. Gastroenterology 2024; 155: 690-703):1649-1659.2024-06-1915 min
Wits & Weights | Fat Loss, Nutrition, & Strength Training for LiftersQuick Wits: Brad Schoenfeld and Maximizing Muscle Growth with Mechanical TensionToday, we're diving into the world of hypertrophy (that's science-speak for muscle growth) and uncovering one of the most powerful principles for packing on size: mechanical tension.Now, if you're a serious lifter or a student of the iron game, you've probably heard of Brad Schoenfeld. He's like the Yoda of muscle-building research, and his work has revolutionized our understanding of what it takes to optimize gains.One of the key concepts that Schoenfeld has championed is the idea that mechanical tension – the force that's generated when our muscles contract against resistance – is the primary driv...2024-05-3006 minEvidence-Based GI: An ACG Publication and PodcastWhen to Discontinue Colorectal Cancer Screening in Older Adults: Chronological Age or Life Expectancy?Philip Schoenfeld, MD, MSEd, MSc (Epi) and Philip Okafor, MD, MPH discuss “Colorectal Cancer Screening Receipt Does Not Differ by 10-Year Mortality Risk among Older Adults,” by Liu PH, Singal AG, Murphy CC. Am J Gastroenterol 2024; 119: 353-63.2024-03-2013 minEvidence-Based GI: An ACG Publication and PodcastICYMI: Eating “Healthy” to Minimize Colon CancerPhilip Schoenfeld, MD, MSEd, MSc (Epi) and Jacqueline Gaulin discuss “Association of Ultra-Processed Food Consumption with Colorectal Cancer Risk Among Men and Women,” by Wang L, Du M, Wang K, et al. BMJ 2022; 378:e068921.2024-03-2014 minEvidence-Based GI: An ACG Publication and PodcastESD vs EMR for Large Non-Pedunculated Colon Polyps: Fewer Recurrences but More ComplicationsPhilip Schoenfeld, MD, MSEd, MSc (Epi) and Jeffrey Lee, MD, MPH discuss “Endoscopic En Bloc Versus Piecemeal Resection of Large Nonpedunculated Colonic Adenomas: A Randomized Comparative Trial,” by Jacques J, Schaefer M, Wallenhorst T, et al. Ann Intern Med 2024; 177: 29-38.2024-03-2014 minEvidence-Based GI: An ACG Publication and PodcastContinued Treatment With Tirzepatide Is Necessary to Maintain Weight LossPhilip Schoenfeld, MD, MSEd, MSc (Epi) and Sonali Paul, MD discuss “Continued treatment with tirzepatide for maintenance of weight reduction in adults with obesity: The SURMOUNT-4 randomized clinical trial,” by Aronne LJ, Horn DB, Bays HE, et al. JAMA 2024; 3310: 38-48.2024-02-2113 minEvidence-Based GI: An ACG Publication and PodcastMaking Bowel Preparation Palatable: Efficacy of a Novel Sports Drink Flavor-Optimized PEG and Sulfate Bowel PreparationPhilip Schoenfeld, MD, MSEd, MSc (Epi) and Ahmad Abu-Heija, MBBS discuss “Comparison of a novel, flavor-optimized, polyethylene glycol and sulfate bowel preparation with oral sulfate solution in adults undergoing colonoscopy,” by Summarizing Bhandari R, Goldstein M, Mishkin DS, et al. J Clin Gastroenterol; 2023;57(9):920-927.2024-02-2115 minEvidence-Based GI: An ACG Publication and PodcastNon-Erosive GERD Does Not Lead to an Increased Risk of Esophageal AdenocarcinomaPhilip Schoenfeld, MD, MSEd, MSc (Epi) and Swathi Eluri, MD, MSCR discuss “Non-erosive gastro-oesophageal reflux disease and incidence of oesophageal adenocarcinoma in three Nordic countries: population based cohort study,” by Holmberg D, Giola S, von Euler-Chelpin M, et al. BMJ 2023; 382: e0760172024-02-2114 minEvidence-Based GI: An ACG Publication and PodcastAdd Prophylactic Pancreatic Duct Stents to Rectal Indomethacin to Minimize Post-ERCP Pancreatitis in High-Risk PatientsPhilip Schoenfeld, MD, MSEd, MSc (Epi) and Joseph Elmunzer, MD, MSc discuss “Indomethacin with or without prophylactic pancreatic stent placement to prevent pancreatitis after ERCP: a randomised trial,” by Elmunzer BJ, Foster LD, Serrano J et al. Lancet 2024; 403: 450-58.2024-02-2125 minEvidence-Based GI: An ACG Publication and PodcastPost-Colonoscopy Colorectal Cancer Due to Missed Polyps in Proximal Colon or Rectum with Sub-Optimal Bowel CleansingPhilip Schoenfeld, MD, MSEd, MSc (Epi) and Jeffrey Lee, MD, MPH discuss “Root-cause Analysis of 762 Danish Post-colonoscopy Colorectal Cancer Patients,” by Troelsen FS, Sørensen HT, Pedersen L, Brix LD, Grode LB, Dekker E, Erichsen R. Clin Gastroenterol Hepatol. 2023 Nov;21(12):3160-3169.e5. Epub 2023 Apr 7.2024-01-1714 minEvidence-Based GI: An ACG Publication and PodcastMirikizumab Is Effective for Induction and Maintenance of Ulcerative ColitisPhilip Schoenfeld, MD, MSEd, MSc (Epi) and Rahul Dalal, MD, MPH discuss “Mirikizumab as Induction and Maintenance Therapy for Ulcerative Colitis,” by D'Haens G, Dubinsky M, Kobayashi T, et al. N Engl J Med. 2023 Jun 29;388(26):2444-2455.2024-01-1711 minEvidence-Based GI: An ACG Publication and PodcastIs Early Ileocecal Resection for Crohn’s Disease An Appropriate Primary Treatment?Philip Schoenfeld, MD, MSEd, MSc and Bharati Kochar, MD, MS discuss “Early Ileocecal Resection for Crohn’s Disease is Associated with Improved Long-Term Outcomes Compared with Anti-Tumor Necrosis Factor Therapy: A Population-Based Cohort Study,” by Agrawal M, Ebert AC, Poulsen G, et al. Gastroenterology 2023; 165:976-985.2024-01-1712 minEvidence-Based GI: An ACG Publication and PodcastWhich Endoscopists Benefit from Using Computer-Aided Detection of Polyps During Colonoscopy?Philip Schoenfeld, MD, MSEd, MSc (Epi) and Jacqueline Gaulin discuss “Endoscopist-Level and Procedure-Level Factors Associated with Increased Adenoma Detection With the Use of a Computer-Aided Detection Device,” by Shaukat A, Lichtenstein DR, Chung DC, et al. Am J Gastroenterol 2023; 118: 1891-94.2024-01-1712 minEvidence-Based GI: An ACG Publication and PodcastICYMI: Lynch Syndrome-An Aspirin a Day Keeps Colorectal Cancer Away!Philip Schoenfeld, MD, MSEd, MSc (Epi) and Swati Patel, MD, MS discuss “Cancer prevention with aspirin in hereditary colorectal cancer (Lynch syndrome), 10-year follow-up and registry-based 20-year data in the CAPP2 study: a double-blind, randomised, placebo-controlled trial,” by Burn J, Sheth H, Elliot F, et al. Lancet 2020;395:1855-63.2023-12-1310 minEvidence-Based GI: An ACG Publication and PodcastHepatocellular Carcinoma Incidence Rates Are 2%-3% in US Patients with Cirrhosis Regardless of EtiologyPhilip Schoenfeld, MD, MSEd, MSc (Epi) and Nicole Rich, MD, MSCS discuss “Incidence and risk factors for hepatocellular carcinoma in cirrhosis: the multicenter Hepatocellular Carcinoma Early Detection Strategy (HEDS) study,” by Reddy KR, McLerran D, Marsh T et al. Gastroenterology 2023; 165(4): 1053-1063.e6.2023-12-1309 minEvidence-Based GI: An ACG Publication and PodcastLow-dose Tricyclic Antidepressants for Irritable Bowel Syndrome: Definitive Evidence of Benefit from ATLANTISPhilip Schoenfeld, MD, MSEd, MSc (Epi) and Jacqueline Gaulin discuss “Amitriptyline at Low-Dose and Titrated for Irritable Bowel Syndrome as Second-Line Treatment in Primary Care (ATLANTIS): A Randomised, Double-Blind, Placebo-Controlled, Phase 3 Trial,” by Ford AC, Wright-Hughes A, Alderson S, et al. Lancet 2023; 402: 1773-85.2023-12-1316 minEvidence-Based GI: An ACG Publication and PodcastOvert Evidence for the Efficacy and Safety of Thalidomide in Gastrointestinal Bleeding from Small Intestinal AngiodysplasiaPhilip Schoenfeld, MD, MSEd, MSc (Epi) and Philip Okafor, MD, MPH discuss “Thalidomide for Recurrent Bleeding Due to Small Intestinal Angiodysplasia,” by Chen H, Wu S, Tang M et al. N Engl J Med 2023 Nov 2;389(18):1649-1659.2023-12-1313 minEvidence-Based GI: An ACG Publication and PodcastGI Adverse Events with GLP-1 Agonists for Weight Loss: Understanding the RisksPhilip Schoenfeld, MD, MSEd, MSc (Epi) and Sonali Paul, MD, MS discuss “Risk of Gastrointestinal Adverse Events Associated with Glucagon-Like Peptide-1 Receptor Agonists for Weight Loss,” by Sodhi M, Rezaeianzadeh R, Kezouh A, Etminan M. JAMA Medicine 2023; In Press.2023-11-1511 minEvidence-Based GI: An ACG Publication and PodcastSurveillance of Branch Duct IPMN – Enough is Enough, At Least in Older Adults and Small, Stable LesionsPhilip Schoenfeld, MD, MSEd, MSc (Epi) and Shria Kumar, MD, MSCE discuss “Surveillance for Presumed BD-IPMN of the Pancreas: Stability, Size, and Age Identify Targets for Discontinuation,” by Marchegiani G, Pollini T, Burelli A, et al. Gastroenterology 2023 Oct;165(4):1016-1024.e52023-11-1509 minEvidence-Based GI: An ACG Publication and PodcastPost-Endoscopy Esophageal Adenocarcinoma: Take a PEEC at Endoscopy Quality in Barrett's EsophagusPhilip Schoenfeld, MD, MSEd, MSc (Epi) and Jennifer Kolb, MD, MPH discuss “Magnitude and Time-Trends of Post-Endoscopy Esophageal Adenocarcinoma and Post-Endoscopy Esophageal Neoplasia in a Population-Based Cohort Study: The Nordic Barrett's Esophagus Study,” by Wani S, Holmberg D, Santonin G, et al. Gastroenterology 2023; 165:909-19.2023-11-1511 minEvidence-Based GI: An ACG Publication and PodcastEtrasimod, a Sphingosine 1-Phosphate Receptor Modulator, for Moderate-Severe Ulcerative Colitis: New Options for Oral TherapyPhilip Schoenfeld, MD, MSEd, MSc (Epi) and Rahul Dalal, MD, MS discuss “Etrasimod as Induction and Maintenance Therapy for Ulcerative Colitis (ELEVATE): Two Randomised, Double-Blind, Placebo-Controlled, Phase 3 Studies,” by Sandborn WJ, Vermeire S, Peyrin-Biroulet L, et al. Lancet 2023; 401: 1159-71.2023-11-1509 minEvidence-Based GI: An ACG Publication and PodcastPPIs are NOT Associated with Dementia: Refuting Sensational Claims in a Post-Modern Epidemiologic EraPhilip Schoenfeld, MD, MSEd, MSc (Epi) and Jacqueline Gaulin discuss “Association of Proton Pump Inhibitor Use with Incident Dementia and Cognitive Decline in Older Adults: A Prospective Cohort Study,” by Mehta R, Kochra B, Zhou Z, et al. Gastroenterology 2023; 165: 564-72.2023-10-1812 minEvidence-Based GI: An ACG Publication and PodcastThe New Frontier of Combination Therapy for IBD: The VEGA RCTPhilip Schoenfeld, MD, MSEd, MSc (Epi) and Bharati Kochar, MD, MS discuss “Guselkumab plus golimumab combination therapy versus guselkumab or golimumab monotherapy in patients with ulcerative colitis (VEGA): a randomised, double-blind, controlled, phase 2, proof-of-concept trial,” by Feagan BG, Sands BE, Sandborn WJ, et al. Lancet Gastroenterol Hepatol. 2023; 8: 307-20.2023-10-1816 minEvidence-Based GI: An ACG Publication and PodcastICYMI: Biosimilar BI 695501 Has Similar Safety and Efficacy to Adalimumab for the Treatment of Crohn’s Disease: VOLTAIRE-CD StudyPhilip Schoenfeld, MD, MSEd, MSc (Epi) and Rahul Dalal, MD, MPH discuss “Safety and efficacy of BI 695501 versus adalimumab reference product in patients with advanced Crohn's disease (VOLTAIRE-CD): a multicentre, randomised, double-blind, phase 3 trial,” by Hanauer S, Liedert B, Balser S, et al. Lancet Gastroenterol Hepatol. 2021 Oct;6(10):816-825. Epub 2021 Aug 11.2023-10-1810 minEvidence-Based GI: An ACG Publication and PodcastHepatitis C Virus Testing and Treatment - A Call To ActionPhilip Schoenfeld, MD, MSEd, MSc (Epi) and Sonali Paul, MD, MS discuss “Hepatitis C Treatment Initiation Among US Medicaid Enrollees,” by Kapadia SN, Zhang H, Gonzalez CJ, et al. JAMA Netw Open. 2023 Aug 1;6(8):e2327326.2023-10-1812 minEvidence-Based GI: An ACG Publication and PodcastLong Road to Achieving Competence in Cold Snare Polypectomy: Video-Based Feedback Can Help!Philip Schoenfeld, MD, MSEd, MSc (Epi) and Swati Patel, MD, MS discuss “Varied Trainee Competence in Cold Snare Polypectomy - Results of the COMPLETE Randomized Controlled Trial,” by Kaltenbach T, Patel SG, Nguyen-Vu T, Malvar C, Keswani RN, Hall M, Aagaard E, Asokkumar R, Chin YK, Hammad H, Rastogi A, Shergill A, Simon V, Soetikno A, Soetikno R, Wani S. Am J Gastroenterol. [2023 Jun 13].2023-09-1316 minEvidence-Based GI: An ACG Publication and PodcastAmerican College of Physicians Guidance Statement on Colorectal Cancer Screening: Pitfalls of Second-Guessing GuidelinesPhilip Schoenfeld, MD, MSEd, MSc (Epi) and Jacqueline Gaulin discuss “Screening for Colorectal Cancer in Asymptomatic Average-Risk Adults: A Guidance Statement from the American College of Physicians (Version 2),” by Qaseem A, Harrod CS, Crandall CJ, et al. Annals of Internal Medicine [2023; 176: 1092-1100].2023-09-1320 minEvidence-Based GI: An ACG Publication and PodcastCannabidiol: A Potential Therapeutic Option for Idiopathic and Diabetic GastroparesisPhilip Schoenfeld, MD, MSEd, MSc (Epi), Philip Okafor, MD, MPH, and Linda Nguyen, MD discuss “A Randomized Controlled Trial of Efficacy and Safety of Cannabidiol in Idiopathic and Diabetic Gastroparesis,” by Zheng T, BouSaba J, Taylor A et al. Clinical Gastroenterology and Hepatology [2023 Jul 22;S1542-3565(23)00543-8].2023-09-1315 minEvidence-Based GI: An ACG Publication and PodcastTime To Simplify ADR Calculation for Colonoscopy Quality ReportingPhilip Schoenfeld, MD, MSEd, MSc (Epi) and Jeffrey Lee, MD, MPH discuss “Evaluating Different Approaches for Calculating Adenoma Detection Rate: Is Screening Colonoscopy the Gold Standard?” by Corley DA, Jensen CD, Chubak J, Schottinger JE, Halm EA, Udaltsova N. Gastroenterology. [2023 Sep;165(3):784-787.e4].2023-09-1315 minEvidence-Based GI: An ACG Publication and PodcastSurveillance Colonoscopy Recommendations in Older Adults With Limited Life Expectancy– More Work to be Done!Philip Schoenfeld, MD, MSEd, MSc (Epi) and Shria Kumar, MD, MSCE discuss “Association of Life Expectancy With Surveillance Colonoscopy Findings and Follow-up Recommendations in Older Adults,” by Calderwood AH, Tosteson TD, Wang Q, et al. JAMA Intern Med. [2023 May 1;183(5):426-34].2023-08-1614 minEvidence-Based GI: An ACG Publication and PodcastICYMI: Albumin Infusions Do Not Improve Outcomes in Hospitalized Patients with Decompensated Cirrhosis-The ATTIRE TrialPhilip Schoenfeld, MD, MSEd, MSc (Epi) and Nicole Rich, MD, MSCS discuss “A randomized trial of albumin infusions in hospitalized patients with cirrhosis,” by China L, Freemantle N, Forrest E et al. NEJM [2021; 384: 808-817].2023-08-1614 minEvidence-Based GI: An ACG Publication and PodcastKiwifruit-A Specific Food To Improve Stool Frequency in Patients with Mild ConstipationPhilip Schoenfeld, MD, MSEd, MSc (Epi) and Jacqueline Gaulin discuss “Consumption of 2 Green Kiwifruits Daily Improves Constipation and Abdominal Comfort-Results of an International Multicenter Randomized Controlled Trial,” Gearry R, Fukudo S, Barbara G, et al. Am J Gastroenterol [2023; 118: 1058-68].2023-08-1616 minEvidence-Based GI: An ACG Publication and Podcast“Cooking Up Something New” with a One-Food Elimination Diet: A Simpler Approach to Dietary Therapy for Eosinophilic EsophagitisPhilip Schoenfeld, MD, MSEd, MSc (Epi) and Jennifer Kolb, MD, MS discuss “One-food versus six-food elimination diet therapy for the treatment of eosinophilic esophagitis: a multicenter, randomized, open-label trial,” by Kliewer K, Gonsalves N, Dellon E, et al. Lancet Gastro Hepatol [2023;8:408-21].2023-08-1612 minEvidence-Based GI: An ACG Publication and PodcastColonoscopy for Colon Polyp Surveillance: Avoid Recommending Early SurveillancePhilip Schoenfeld, MD, MSEd, MSc (Epi) and Jacqueline Gaulin discuss “Real-World Compliance with the 2020 US Multi-Society Task Force on Colorectal Cancer Polypectomy Surveillance Guidelines: An Observational Study,” by Dong J, Wang LF, Ardolino E, Feuerstein J. Gastrointest Endosc [2023; 97:350-56].2023-07-1210 minEvidence-Based GI: An ACG Publication and PodcastAGA-ACG Clinical Practice Guideline on Chronic Idiopathic Constipation Treatments: Parsing Benefits and RisksJacqueline Gaulin and Editor-in-Chief Philip Schoenfeld, MD, MSEd, MScEpi discuss “AGA-ACG Clinical Practice Guideline: Pharmacological Management of Chronic Idiopathic Constipation,” by Chang L, Chey WD, Imdad A, et al. Am J Gastroenterol [2023; 118: 936-54].2023-06-1410 minEvidence-Based GI: An ACG Publication and PodcastAGA-ACG Clinical Practice Guideline on Chronic Idiopathic Constipation Treatments: Parsing Benefits and RisksJacqueline Gaulin and Editor-in-Chief Philip Schoenfeld, MD, MSEd, MScEpi discuss “AGA-ACG Clinical Practice Guideline: Pharmacological Management of Chronic Idiopathic Constipation,” by Chang L, Chey WD, Imdad A, et al. Am J Gastroenterol [2023; 118: 936-54].2023-06-1410 minEvidence-Based GI: An ACG Publication and PodcastScreening Colonoscopy in the Elderly Population-Is Less Better?Philip Okafor, MD, MPH and Editor-in-Chief Philip Schoenfeld, MD, MSEd, MScEpi discuss “Frequency of Use and Outcomes in Individuals Older than 75 Years,” by El Halabi J, Burke CA, Hariri E, et al. JAMA Internal Medicine [2023; 183: 513-19].2023-06-1411 minEvidence-Based GI: An ACG Publication and PodcastFree Online Program Improves Adenoma Detection Rate and Decreases Post-Colonoscopy Colorectal CancerJeffrey Lee, MD, MPH and Editor-in-Chief Philip Schoenfeld, MD, MSEd, MScEpi discuss “Impact of a Scalable Training Program on the Quality of Colonoscopy Performance and Risk of Post-Colonoscopy Colorectal Cancer,” by Corley DA, Jensen CD, Lee JK, et al. Gastrointest Endosc [2023; In Press].2023-06-1409 minEvidence-Based GI: An ACG Publication and PodcastProphylactic Antibiotics Do Not Improve Mortality in Severe Alcoholic Hepatitis Treated with CorticosteroidsEditor-in-Chief Philip Schoenfeld, MD, MSEd, MScEpi discusses “Effect of Prophylactic Antibiotics on Mortality in Severe Alcohol-Related Hepatitis,” by Louvet A, Labreuche J, Dao T, et al. [JAMA 2023; 329 (18): 1558-66].2023-05-1710 minEvidence-Based GI: An ACG Publication and PodcastOver-the-Scope Clips Decrease Non-Variceal Upper GI Bleeding vs Standard Endoscopic Treatment… In the Right PatientJennifer Kolb, MD, MS and Editor-in-Chief Philip Schoenfeld, MD, MSEd, MScEpi discuss “Comparison of Over-the-Scope Clips to Standard Endoscopic Treatment as the Initial Treatment in Patients With Bleeding From a Nonvariceal Upper Gastrointestinal Cause: A Randomized Controlled Trial,” by Lau JYW, Li R, Tan C et al. Ann Intern Med [2023 Apr;176(4):455-462].2023-05-1711 minEvidence-Based GI: An ACG Publication and PodcastDisposable Elevator Caps for Duodenoscopes Decrease Persistent Bacterial Contamination Without Hindering Technical ERCP Performance: The ICECAP TrialShria Kumar, MD, MSCE and Editor-in-Chief Philip Schoenfeld, MD, MSEd, MScEpi discuss “Effect of Disposable Elevator Cap Duodenoscopes on Persistent Microbial Contamination and Technical Performance of Endoscopic Retrograde Cholangiopancreatography: The ICECAP Randomized Clinical Trial,” by Forbes N, Elmunzer BJ, Allain T, et al. JAMA Intern Med [2023;183(3):191-200].2023-05-1707 minEvidence-Based GI: An ACG Publication and PodcastSEAVUE: a Sea of Change in Biologic Positioning for Crohn’s DiseaseBharati Kochar, MD, MS and Editor-in-Chief Philip Schoenfeld, MD, MSEd discuss “Ustekinumab versus adalimumab for induction and maintenance therapy in biologic-naive patients with moderately to severely active Crohn’s disease: a multicentre, randomised, double-blind, parallel-group, phase 3b trial,” by Sands BE, Irving PM, Hoops T, et al. Lancet [2022;399(10342):2200-2211].2023-04-1914 minEvidence-Based GI: An ACG Publication and PodcastICYMI: Vedolizumab Is Superior to Adalimumab for Clinical Remission and Endoscopic Improvement of Ulcerative Colitis-The VARSITY RCTJessica Allegretti, MD, MPH and Editor-in-Chief Philip Schoenfeld, MD, MSEd, MScEpi discuss “Vedolizumab versus Adalimumab for Moderate-to-Severe Ulcerative Colitis,” by Sands BE, Peyrin-Biroulet L, Loftus EV Jr, Danese S, Colombel JF, Toruner M, Jonaitis L, Abhyankar B, Chen J, Rogers R, Lirio RA, Bornstein JD, Schreiber S. N Engl J Med [2019 Sep 26;381(13):1215-1226].2023-04-1911 minEvidence-Based GI: An ACG Publication and PodcastVibrating Capsules for Chronic Constipation: The New Non-Pharmacologic ApproachEditor-in-Chief Philip Schoenfeld, MD, MSEd, MScEpi discussesEditor-in-Chief Philip Schoenfeld, MD, MSEd, MScEpi discusses “Randomized Placebo-Controlled Phase 3 Trial of Vibrating Capsule for Chronic Constipation,” by Rao S, Quigley EMM, Chey WD, et al. Gastroenterology [2023].2023-04-1909 minEvidence-Based GI: An ACG Publication and PodcastICYMI: Can we prevent hepatic decompensation? Most likely, with nonselective beta blockers.Sonali Paul, MD, MS, and Editor-in-Chief Philip Schoenfeld, MD, MSEd, MScEpi discuss “Beta blockers to prevent decompensation of cirrhosis in patients with clinically significant portal hypertension (PREDESCI): a randomized, double-blind, placebo-controlled, multicenter trial,” by Villanueva C, Albillos A, Genesca J, et al. Lancet [2019, Apr 20;393(10181):1597-1608]. Erratum in: Lancet [2019 Jun 22;393(10190):2492].2023-04-1909 minEvidence-Based GI: An ACG Publication and PodcastVibrating Capsules for Chronic Constipation: The New Non-Pharmacologic ApproachEditor-in-Chief Philip Schoenfeld, MD, MSEd, MScEpi discussesEditor-in-Chief Philip Schoenfeld, MD, MSEd, MScEpi discusses “Randomized Placebo-Controlled Phase 3 Trial of Vibrating Capsule for Chronic Constipation,” by Rao S, Quigley EMM, Chey WD, et al. Gastroenterology [2023].2023-04-1909 min
Tuesday Night IBSNew & Novel Management for IBS-C: Evaluating all the OptionsDid you know #IBS-C is the most commonly diagnosed Disorder of Gut Brain Interaction (DGBI) with a high level of illness burden & decreased QoL? Let's start treating #IBS-C w/the tools we have available! Hear more about the new and novel therapy available as well as simple lifestyle changes that can improve symptoms. Dr. Philip Schoenfeld and Dr. Megan Riehl discuss Tenapanor for medical management, relaxation and breathing tips before and during a bowel movement and Suzanne, IBS patient advocate shares her powerful story of illness and relief.
2023-03-2835 minEvidence-Based GI: An ACG Publication and PodcastCold Snare Decreases Post-Polypectomy Bleeding vs Hot Snare for Small PolypsEditor-in-Chief Philip Schoenfeld, MD, MSEd, MScEpi discusses “Cold Versus Hot Snare Polypectomy for Small Colorectal Polyps: A Pragmatic Randomized Controlled Trial,” by Chang LC, Chang CY, Chen CY, et al. Ann Intern Med [2023; In Press].2023-03-1510 minEvidence-Based GI: An ACG Publication and Podcast10-Year Intervals After Normal Screening Colonoscopy: It’s Not Too Long with High-Quality ColonoscopyPhilip Okafor MD, MPH and Editor-in-Chief Philip Schoenfeld, MD, MSEd, MScEpi discuss “Prevalence of Colorectal Neoplasia 10 or More Years After A Negative Screening Colonoscopy in 120,000 Repeated Screening Colonoscopies,” by Heisser T, Kretschmann J, Hagen B, et al. JAMA Intern Med [2023; 183: 183-90].2023-03-1507 minEvidence-Based GI: An ACG Publication and PodcastWhat are the Causes of Post-colonoscopy Colorectal Cancer?Jeffrey Lee, MD, MPH and Editor-in-Chief Philip Schoenfeld, MD, MSEd, MScEpi discuss “Post-Colonoscopy Colorectal Cancer Etiologies in a Large Integrated US Health Care Setting,” by Leung LJ, Lee JK, Merchant SA, Jensen CD, Alam A, Corley DA. Gastroenterology [2022. PMID: 36462551].2023-03-1513 minEvidence-Based GI: An ACG Publication and PodcastTumor-based screening for Lynch Syndrome: Check Every Colorectal CancerSwati G. Patel, MD, MS and Editor-in-Chief Philip Schoenfeld, MD, MSEd, MScEpi discuss “A Canadian Provincial Screening Program for Lynch Syndrome,” by Stone JK, Winter R, Khan D, Rothenmund H, Klein J, Chodirker B, Wightman R, Kim CA, Nugent Z, Singh H. American Journal of Gastroenterology [2023;118:345-53].2023-03-1514 minEvidence-Based GI: An ACG Publication and PodcastDirect-Acting Antiviral Therapy for Hepatitis C Virus Decreases All-Cause Mortality and Decompensated Cirrhosis: Treat (Virtually) EveryoneEditor-in-Chief Philip Schoenfeld, MD, MSEd, MScEpi FACG discusses “Association of Direct-Acting Antiviral Therapy with Liver and Nonliver Complications and Long-term Mortality in Patients with Chronic Hepatitis C,” by Ogawa E, Chien N, Kam L, et al. JAMA Internal Medicine [2023; 183: 97-105].2023-02-2206 minEvidence-Based GI: An ACG Publication and PodcastEarly Colonoscopy for Acute Lower GI Bleeding Usually Is Not the AnswerShria Kumar, MD, MSCE and Editor-in-Chief Philip Schoenfeld, MD, MSEd, MScEpi FACG discuss “Timing of Colonoscopy in Acute Lower GI Bleeding: A Multicenter Retrospective Cohort Study,” by Shiratori Y, Ishii N, Tomonori A, et al. Gastrointest Endosc [2023; 97: 89-99].2023-02-2210 minEvidence-Based GI: An ACG Publication and PodcastEndoscopic Sleeve Gastroplasty Is Effective for Patients with Obesity Who MERIT InterventionJennifer Kolb, MD, MS and Editor-in-Chief Philip Schoenfeld, MD, MSEd, MScEpi FACG discuss “Endoscopic Sleeve Gastroplasty for Treatment of Class 1 and 2 Obesity (MERIT), a Prospective, Multicentre, Randomised Trial,” by Dayyeh BKA, Bazerbachi F, Vargas EJ, et al. Lancet [2022; 400: 441-51].2023-02-2210 minEvidence-Based GI: An ACG Publication and PodcastDupilumab, an IgG4 Monoclonal Antibody, for Eosinophilic Esophagitis: Revising the Treatment ParadigmAfrin Kamal, MD, MS and Editor-in-Chief Philip Schoenfeld, MD, MSEd, MScEpi discuss “Dupilumab in Adults and Adolescents with Eosinophilic Esophagitis,” by Dellon ES, Rothenber MH, Collins I, et al. N Engl J Med [2022; 387: 2317-30].2023-02-2215 minEvidence-Based GI: An ACG Publication and PodcastICYMI: Is Terlipressin for the Treatment of Hepato-Renal Syndrome Ready for Primetime: Results of the CONFIRM TrialEditor-in-Chief Philip Schoenfeld, MD, MSEd, MScEpi FACG and Sonali Paul, MD, MS discuss “Terlipressin plus Albumin for the Treatment of Type 1 Hepatorenal Syndrome,” by Wong F, Pappas SC, Curry KR, et al. N Engl J Med [2021; 384: 818-28].2023-02-0308 minEvidence-Based GI: An ACG Publication and PodcastRisankizumab, an Interleukin-23 Inhibitor, for Moderate-Severe Crohn’s Disease: Advancing Care Beyond Anti-TNF TherapyBharati Kochar, MD, MS and Editor-in-Chief Philip Schoenfeld, MD, MSEd, MScEpi discuss “Risankizumab as Induction Therapy for Crohn’s Disease: Results from the Phase 3 ADVANCE and MOTIVATE Induction Trials,” by D’Haens G, Panaccione R, Baert F, et al. Lancet [2022; 399: 2015-30].2023-01-2517 minEvidence-Based GI: An ACG Publication and PodcastRisankizumab, an Interleukin-23 Inhibitor, for Moderate-Severe Crohn’s Disease: Advancing Care Beyond Anti-TNF TherapyJessica Allegretti, MD, MPH and Editor-in-Chief Philip Schoenfeld, MD, MSEd, MScEpi FACG discuss “Risankizumab as maintenance therapy for moderately to severely active Crohn's disease: results from the multicentre, randomised, double-blind, placebo-controlled, withdrawal phase 3 FORTIFY maintenance trial,” by Ferrante M, Panaccione R, Baert F, et al. Lancet [2022 May 28;399(10340):2031-2046].2023-01-2510 minEvidence-Based GI: An ACG Publication and PodcastWhen It’s Not Acid Reflux: Managing PPI-Resistant GERD Patients Based on Bravo ResultsEditor-in-Chief Philip Schoenfeld, MD, MSEd, MScEpi FACG and Kristle Lee Lynch, MD discuss “Optimal Wireless Reflux Monitoring Metrics to Predict Discontinuation of Proton Pump Inhibitor Therapy,” by Yadlapati R, Gyawali CP, Masihi M, et al. Am J Gastroenterol [2022 Oct 1;117(10):1573-1582].2023-01-2510 minEvidence-Based GI: An ACG Publication and PodcastOzanimod, a Selective Selective Sphingosine-1-Phosphatase Receptor Modulator, for Moderate-Severe Ulcerative Colitis: Re-Thinking the Top-Down Treatment Algorithm for UCOriana Damas, MD and Editor-in-Chief Philip Schoenfeld, MD, MSEd, MScEpi discuss “Ozanimod for Induction and Maintenance of Ulcerative Colitis,” by Sandborn WJ, Feagan BG, D’Haens G, et al. N Engl J Med [2021; 385: 1280-91].2022-12-1317 minEvidence-Based GI: An ACG Publication and PodcastContinuing Anti-TNF Agents past 24 Weeks of Pregnancy Associated with Fewer IBD Relapses with No Increase in Adverse Fetal OutcomesAhmad Abu-Heija, MBBS and Editor-in-Chief Philip Schoenfeld, MD, MSEd, MScEpi FACG discuss “Benefits and Risks Associated with Continuation of Anti-Tumor Necrosis Factor After 24 Weeks of Pregnancy in Women With Inflammatory Bowel Disease,” by Meyer A, Neumann A, Drouin J, et al. Ann Intern Med [2022; 175(10) 1374-82].2022-12-1312 minEvidence-Based GI: An ACG Publication and PodcastNSAID Use and the Risk of IBD Exacerbations: Fact or FictionPhilip Okafor, MD, MPH and Editor-in-Chief Philip Schoenfeld, MD, MSEd, MScEpi FACG discuss “The Association Between Nonsteroidal Anti-Inflammatory Drug Use and Inflammatory Bowel Disease Exacerbations: A True Association or Residual Bias?” by Cohen-Mekelburg S, Van T, Wallace B, et al. Am J Gastroenterol [2022; 117 (11): 1851-57].2022-12-1315 minEvidence-Based GI: An ACG Publication and PodcastRBX2660, a Donor Stool Product for Fecal Microbiota Transplant, Decreases Recurrent Clostridioides difficile Infection: The First FDA-Approved Live Biotherapeutic ProductCollen R. Kelly, MD and Editor-in-Chief Philip Schoenfeld, MD, MSEd, MScEpi FACGdiscuss “Efficacy and Safety of RBX2660 in PUNCH CD3, a Phase III, Randomized, Double-Blind, Placebo-Controlled Trial with a Bayesian Primary Analysis for the Prevention of Recurrent Clostridioides difficile Infection,” by Khanna S, Assi M, Lee C. et al. Drugs [2022; 82: 1527-1538].2022-12-1319 minEvidence-Based GI: An ACG Publication and PodcastReinvestigating the Lack of Association Between Proton Pump Inhibitor Use and Mortality by Accounting for Reverse CausationRavy Vajravelu, MD, MSCE and Editor-in-Chief Philip Schoenfeld, MD, MSEd, MScEpi FACG discuss “Association of Proton Pump Inhibitor Use With All-Cause and Cause-Specific Mortality,” by Lo CH, Ni P, Yan Y, et al. Gastroenterology [2022; 163:852 – 61].2022-11-1124 minEvidence-Based GI: An ACG Publication and PodcastVonoprazan, a Potassium-Channel Acid Blocker, is Superior to Lansoprazole for Managing Erosive EsophagitisEditor-in-Chief Philip Schoenfeld, MD, MSEd, MScEpi FACG discusses “Vonoprazan versus Lansoprazole for Healing and Maintenance of Healing of Erosive Esophagitis: A Randomized Trial,” by Laine L, DeVault K, Katz P, et al. Gastroenterology [2022; In Press].2022-11-1113 minEvidence-Based GI: An ACG Publication and PodcastICYMI: Surgery is Superior to Medical Therapy for PPI-Refractory Heartburn in the “Right” PatientsJennifer Kolb, MD, MS and Editor-in-Chief Philip Schoenfeld, MD, MSEd, MScEpi FACG discuss “Randomized Trial of Medical versus Surgical Treatment for Refractory Heartburn,” by Spechler SJ, Hunter JG, Jones KM, et al. N Engl J Med [2019;381:1513-1523].2022-11-1117 minEvidence-Based GI: An ACG Publication and PodcastAcute pancreatitis: Need IV fluid resuscitation but avoid a WATERFALL!Shria Kumar, MD, MSCE and Editor-in-Chief Philip Schoenfeld, MD, MSEd, MScEpi FACG discuss “Aggressive or Moderate Fluid Resuscitation in Acute Pancreatitis,” by de-Madaria E, Buxbaum JL, Maisonneuve P, et al, published in N Engl J Med [2022;387(11):989-1000].2022-10-1809 minEvidence-Based GI: An ACG Publication and PodcastHigh Adenoma Detection Rate Decreases Post-Colonoscopy CRC in FIT-Based Screening Program: Quality Matters!Joseph Sleiman, MD and Editor-in-Chief Philip Schoenfeld, MD, MSEd, MScEpi FACG discuss “Adenoma Detection Rate and Risk for Interval Postcolonoscopy Colorectal Cancer in Fecal Immunochemical Test-Based Screening: A Population-Based Cohort Study,” by Wisse PHA, Erler N, de Boer SY, et al, published in Ann Intern Med [2022; In Press].2022-10-1818 minEvidence-Based GI: An ACG Publication and PodcastColonoscopy Reduces CRC Incidence and CRC-Related Mortality…. If You Get It!Editor-in-Chief Philip Schoenfeld, MD, MSEd, MScEpi FACG discusses “Effect of Colonoscopy Screening on Risks of Colorectal Cancer and Related Death,” by Bretthauer M, Løberg M, Wieszczy P, et al, published in N Engl J Med [Oct 9, 2022].2022-10-1813 minEvidence-Based GI: An ACG Publication and PodcastUpadacitinib, a Selective JAK1 Inhibitor, for Moderate-Severe Ulcerative Colitis: Adjusting the Top-Down Treatment Algorithm for UCJami Kinnucan, MD and Editor-in-Chief Philip Schoenfeld, MD, MSEd, MSc (Epi) discuss “Upadacitinib as Induction and Maintenance Therapy for Moderately to Severely Active Ulcerative Colitis: Results from Three Phase 3, Multicentre, Double-Blind, Randomised Trials,” by Danese S, Vermeire S, Zhou W, et al, published in Lancet [2022; 399: 2113-28].2022-10-1831 minEvidence-Based GI: An ACG Publication and PodcastAchieve IBD Remission Before Pregnancy: PIANO Registry Data Shows Adverse Perinatal Outcomes For Infants Associated with IBD Flares and Steroid Use; and Continue Thiopurines and Anti-TNF Agents If Your IBD Patient Becomes PregnantEditor-in-Chief Philip Schoenfeld, MD, MSEd, MScEpi FACG discusses “Exposure to Corticosteroids in Pregnancy Is Associated with Adverse Perinatal Outcomes Among Infants of Mothers with Inflammatory Bowel Disease,” by Odufalu FD, Long MD, Lin K, Mahadaven U for PIANO Investigators, published in GUT [2022; 71: 1766-72] and also “Pregnancy and Neonatal Outcomes After Fetal Exposure to Biologics and Thiopurines Among Women With Inflammatory Bowel Disease,” by Mahadevan U, Long MD, Kane SV, et al, published in Gastroenterology [2021 Mar;160(4):1131-1139]2022-09-2116 minEvidence-Based GI: An ACG Publication and PodcastICYMI-Pantoprazole Prophylaxis Does Not Reduce 90-day Mortality and Clinically Significant Adverse Events in ICU PatientsPhilip Okafor, MD, MPH and Editor-in-Chief Philip Schoenfeld, MD, MSEd, MScEpi FACG discuss “Pantoprazole in Patients at Risk for Gastrointestinal for Gastrointestinal Bleeding in the ICU,” by Krag M, Marker S, Perner A et al, published in NEJM [379; 23: 2018].2022-09-2115 minEvidence-Based GI: An ACG Publication and PodcastTime to Increase Adenoma Detection Rate Benchmarks for Screening ColonoscopiesEditor-in-Chief Philip Schoenfeld, MD, MSEd, MScEpi FACG discusses “Pregnancy and Neonatal Outcomes After Fetal Exposure to Biologics and Thiopurines Among Women With Inflammatory Bowel Disease,” by Mahadevan U, Long MD, Kane SV, et al, published in Gastroenterology [2021 Mar;160(4):1131-1139].2022-09-2122 minTuesday Night IBSEfficacy of Linaclotide in IBS-C: A review with Evidence Based GI JournalIn this new episode we talk with Philip Schoenfeld MD @EBGIdoc
& Jill Deutsch MD about their review article: "Treating All the Symptoms of IBS-C: a review of the data on Linaclotide" We break down the role for Secretagogues in IBS-C management, the efficacy data on pain reduction as well as normalization of bowel habit and how this relates to everyday patient care. It's a great discussion that you will not want to miss!2022-09-1643 minEvidence-Based GI: An ACG Publication and PodcastProphylactic Rifaximin Decreases Post-TIPS Hepatic EncephalopathyEditor-in-Chief Philip Schoenfeld, MD, MSEd, MScEpi FACG discusses “The Use of Rifaximin in the Prevention of Overt Hepatic Encephalopathy After Transjugular Intrahepatic Portosystemic Shunt : A Randomized Controlled Trial,” by Bureau et al, published in Ann Intern Med [2021 May;174(5):633-640].https://pubmed.ncbi.nlm.nih.gov/33524293/2022-08-1112 minEvidence-Based GI: An ACG Publication and PodcastTiny Polyps-It’s OK to Remove Polyps equal or less than 3mm with Large Biopsy ForcepsShria Kumar, MD, MSCE and Editor-in-Chief Philip Schoenfeld, MD, MSEd, MScEpi FACG discuss “Randomized Controlled Trial Investigating Cold Snare and Forceps Polypectomy Among Small POLYPs in Rates of Complete Resection: The TINYPOLYP Trial,” by Wei et al, published in Am J Gastroenterol [2022 Aug 1;117(8):1305-1310]. https://pubmed.ncbi.nlm.nih.gov/35467557/2022-08-1112 minEvidence-Based GI: An ACG Publication and PodcastADR Isn’t the Only Game in Town: Proximal Serrated Lesion Detection Rates Predicts Interval Cancer RiskSwati Patel, MD, MS and Editor-in-Chief Philip Schoenfeld, MD, MSEd, MScEpi FACG discuss “Serrated polyp detection and risk of interval post-colonoscopy colorectal cancer: a population-based study,” by van Toledo et al, published in Lancet Gastroenterol Hepatol [2022 Aug;7(8):747-754]. https://pubmed.ncbi.nlm.nih.gov/35550250/2022-08-1116 minEvidence-Based GI: An ACG Publication and PodcastSER-109, an Oral Microbiome Therapy, Decreases Recurrent Clostridiodes difficile InfectionAssociate Editor Jessica Allegretti, MD, MPH and Editor-in-Chief Philip Schoenfeld, MD, MSEd, MScEpi FACG discuss “SER-109, an Oral Microbiome Therapy for Recurrent Clostridioides difficile Infection” by Feuerstadt et al, published in N Engl J Med [2022;386(3):220-229]. https://pubmed.ncbi.nlm.nih.gov/35045228/2022-06-1611 minEvidence-Based GI: An ACG Publication and PodcastWhen Is Routine Prophylactic Clipping Indicated Post-Polypectomy?Associate Editor Jeffrey Lee, MD, MPH and Editor-in-Chief Philip Schoenfeld, MD, MSEd, MScEpi FACG discuss “Effect of prophylactic endoscopic clip placement on clinically significant post-endoscopic mucosal resection bleeding in the right colon: a single-centre, randomised controlled trial” by Gupta et al, published in Lancet Gastroenterol Hepatol [2022;7(2):152-160]. https://pubmed.ncbi.nlm.nih.gov/34801133/2022-06-0913 minEvidence-Based GI: An ACG Publication and PodcastTenapanor (IBSRELA) for Treatment of IBS-C: Effective over 26 WeeksEditor-in-Chief Philip Schoenfeld, MD, MSEd, MScEpi FACG discusses “Efficacy of Tenapanor in Treating Patients With Irritable Bowel Syndrome with Constipation: A 26-Week, Placebo-Controlled Phase 3 Trial (T3MPO-2)” by Chey et al, published in Am J Gastroenterol [2021;116: 1294-1303]. https://pubmed.ncbi.nlm.nih.gov/33337659/2022-06-0211 minEvidence-Based GI: An ACG Publication and PodcastLow Grade Dysplasia in Barrett’s Esophagus – Get Two Expert GI Pathologist Reviews and Repeat EGD After PPI TreatmentAssociate Editor Shria Kumar, MD, MSCE and Editor-in-Chief Philip Schoenfeld, MD, MSEd, MScEpi FACG discuss “Discordance Among Pathologists in the United States and Europe in Diagnosis of Low-Grade Dysplasia for Patients With Barrett’s Esophagus” by Vennalaganti et al, published in Gastroenterology [2017 Feb;152(3):564-570.e4]. https://pubmed.ncbi.nlm.nih.gov/27818167/2022-05-0515 minEvidence-Based GI: An ACG Publication and PodcastTherapeutic Drug Monitoring of Maintenance Infliximab Is Beneficial for Patients with Immunemediated Inflammatory DiseasesAssociate Editor Jessica R. Allegretti, MD, MPH and Editor-in-Chief Philip Schoenfeld, MD, MSEd, MScEpi FACG discuss “Effect of Therapeutic Drug Monitoring vs Standard Therapy During Maintenance Infliximab Therapy on Disease Control in Patients With Immune-Mediated Inflammatory Diseases: A Randomized Clinical Trial” by Syversen et al, published in JAMA [2021; 326(23):2375-2384]. https://pubmed.ncbi.nlm.nih.gov/34932077/2022-04-1411 minEvidence-Based GI: An ACG Publication and PodcastEndoscopic Eradication Therapy for Neoplastic Barrett’s Esophagus Demonstrates 94% Treatment Success and Long-term DurabilityAssociate Editor Jennifer M Kolb MD, MS and Editor-in-Chief Philip Schoenfeld, MD, MSEd, MScEpi FACG discuss “Long-term Outcomes after Endoscopic Treatment for Barrett’s Neoplasia with Radiofrequency Ablation ± Endoscopic Resection: Results from the National Dutch Database in a 10-year Period” by Munster et al, published in Gut [2022;71:265-76]. https://pubmed.ncbi.nlm.nih.gov/33753417/2022-04-0717 minEvidence-Based GI: An ACG Publication and PodcastIncreased Risk of Metachronous Neoplasia After Incomplete Polyp Resection – Time to CARE About Polypectomy Technique!Associate Editor Jeffrey Lee, MD, MPH and Editor-in-Chief Philip Schoenfeld, MD, MSEd, MScEpi FACG discuss “Recurrence of Colorectal Neoplastic Polyps After Incomplete Resection” by Pohl et al, published in Annals of Internal Medicine. [2021;174(10):1377-1384]. https://pubmed.ncbi.nlm.nih.gov/34370514/2022-02-2417 minEvidence-Based GI: An ACG Publication and PodcastIt’s a Bad “Prep” Even Though the Patient Took It Correctly: Consider 15 mg Bisacodyl plus 4-Liter PEG Split Prep Before Next ColonoscopyEditor-in-Chief Philip Schoenfeld, MD, MSEd, MScEpi FACG discusses “A Multicenter Randomized Controlled Trial Comparing Bowel Cleansing Regimens for Colonoscopy After Failed Bowel Preparation” by Sey at al, published in Clinical Gastroenterology and Hepatology [2022;In Press]. https://pubmed.ncbi.nlm.nih.gov/342561472022-02-1713 minEvidence-Based GI: An ACG Publication and PodcastEffectiveness of Intermittent Fasting for Weight Loss: It’s Not Just When You Eat, but What You Eat, Too!Associate Editor Sonali Paul, MD, MS and Editor-in-Chief Philip Schoenfeld, MD, MSEd, MScEpi FACG discuss “Effects of Time-Restricted Eating on Weight Loss and Other Metabolic Parameters in Women and Men with Overweight and Obesity. The TREAT Randomized Clinical Trial” by Lowe et al, published in JAMA [2021; 181(6):883]. https://pubmed.ncbi.nlm.nih.gov/32986097/2022-02-1017 minEvidence-Based GI: An ACG Publication and PodcastFamily Matters: Increased Risk of Colorectal Cancer among Individuals with Family History of PolypsAssociate Editor Ravy K. Vajravelu, MD, MSCE and Editor-in-Chief Philip Schoenfeld, MD, MSEd, MScEpi FACG discuss “Risk of colorectal cancer in first degree relatives of patients with colorectal polyps: nationwide case-control study in Sweden” by Song et al, published in BMJ [2021;373:n877]. https://pubmed.ncbi.nlm.nih.gov/33947661/2022-02-0321 minEvidence-Based GI: An ACG Publication and PodcastSlow Down to Speed Up Quality: Longer Withdrawal Time of 9 Versus 6 Minutes Increases Adenoma Detection RateAssociate Editor Jennifer M. Kolb MD, MSCS and Editor-in-Chief Philip Schoenfeld, MD, MSEd, MScEpi, FACG discuss “Impact of 9-Minute Withdrawal Time on the Adenoma Detection Rate: A Multicenter Randomized Controlled Trial” by Zhao et al, published in Clinical Gastroenterology and Hepatology [2020;20:31553-6]. https://pubmed.ncbi.nlm.nih.gov/33220526/2022-01-2720 minEvidence-Based GI: An ACG Publication and PodcastDrainage for Infected Pancreatic Necrosis – Earlier Is Not BetterAssociate Editor Shria Kumar, MD, MSCE and Editor-in-Chief Philip Schoenfeld, MD, MSEd, MScEpi, FACG discuss “Immediate versus Postponed Intervention for Infected Necrotizing Pancreatitis” by Boxhoorn et al, published in NEJM. [2021;15:1372-1381]. https://pubmed.ncbi.nlm.nih.gov/34614330/2022-01-2016 minEvidence-Based GI: An ACG Publication and PodcastHereditary Syndrome Risk Assessment in all Colorectal Cancer Patients: Keep it Simple!Associate Editor Swati Patel, MD, MS and Editor-in-Chief Philip Schoenfeld, MD, MSEd, MScEpi, FACG discuss “Prospective Statewide Study of Universal Screening for Hereditary Colorectal Cancer: The Ohio Colorectal Cancer Prevention Initiative” by Pearlman et al, published in JCO Precision Oncology [2021;5:779-91]. https://pubmed.ncbi.nlm.nih.gov/34250417/2022-01-1314 minEvidence-Based GI: An ACG Publication and PodcastTreating All the Symptoms of IBS-C: Linaclotide Significantly Decreases Abdominal Pain, Bloating, and DiscomfortAssociate Editor Jill Deutsch, MD and Editor-in-Chief Philip Schoenfeld, MD, MSEd, MScEpi, FACG discuss “Efficacy of Linaclotide in Reducing Abdominal Symptoms of Bloating, Discomfort, and Pain: A Phase 3B Trial Using a Novel Abdominal Scoring System” by Chang et al, published in American Journal of Gastroenterology [2021;116: 1929-37]. https://pubmed.ncbi.nlm.nih.gov/34465695/2022-01-0617 minEvidence-Based GI: An ACG Publication and PodcastPiecemeal Cold Snare Polypectomy of Large SSP: Cold Is the New HotAssociate Editor Swati Patel, MD, MS and Editor-in-Chief Philip Schoenfeld, MD, MSEd, MScEpi, FACG discuss Piecemeal cold snare polypectomy versus conventional endoscopic mucosal resection for large sessile serrated lesions: a retrospective comparison across two successive periods bt Van Hattem WA, published in Gut [2021;70:1691-97]. https://doi.org/10.1136/gutjnl-2020-3217532021-10-2814 minEvidence-Based GI: An ACG Publication and PodcastOnce-Weekly Semaglutide in Adults with Overweight or ObesityAssociate Editor Sonali Paul, MD, MS and Editor-in-Chief Philip Schoenfeld, MD, MSEd, MScEpi, FACG discuss Semaglutide Treatment Effect in People with Obesity (STEP) Investigators. Once-Weekly Semaglutide in Adults with Overweight or Obesity by Wilding et al, published in the New England Journal of Medicine [2021; 384: 989-1002. https://www.nejm.org/doi/10.1056/NEJMoa20321832021-10-2115 minEvidence-Based GI: An ACG Publication and PodcastScreening Colonoscopy Decreases Colorectal Cancer Incidence and Related Mortality in Healthy Patients Over 75Associate Editor Jeffrey Lee, MD, MPH and Editor-in-Chief Philip Schoenfeld, MD, MSEd, MScEpi, FACG discuss Association of Screening Lower Endoscopy with Colorectal Cancer Incidence and Mortality in Adults Older than 75 Years by Ma et al, published in .JAMA Oncology [2021;7(7):985-992]. https://doi.org/10.1001/jamaoncol.2021.13642021-10-1415 min