Shows
Cell & Gene: The PodcastAdvancing Allogeneic Cell Therapy for SCI and Blindness with Lineage's Brian CulleyWe love to hear from our listeners. Send us a message.On episode 114 of Cell & Gene: The Podcast, Host Erin Harris talks to Brian Culley, CEO of Lineage Cell Therapeutics, about advancing cell therapy beyond oncology and into transformative treatments for conditions such as spinal cord injury and blindness. Culley shares how Lineage’s allogeneic, off-the-shelf approach, anchored by its OPC1 program, aims to replace lost or damaged cells to restore function, starting with patients who have plateaued after chronic spinal cord injury. He details the DOSED study’s innovative delivery device and thaw-and-inject formulation, both designed to s...
2025-10-2326 minCell & Gene: The PodcastHow AI and ML Drive iPSC Quality with Aspen Neuroscience's Thorsten Gorba, Ph.D.We love to hear from our listeners. Send us a message.Welcome to Episode 113 of Cell & Gene: The Podcast. Host Erin Harris is joined by Thorsten Gorba, Ph.D., VP Process Development at Aspen Neuroscience to explore how the company is advancing the field of cell therapy manufacturing. Aspen Neuroscience stands at the forefront of integrating machine vision and AI/ML to assess induced pluripotent stem cell (iPSC) colony quality by offering a transformative approach to move beyond the subjective nature of manual evaluation. Dr. Gorba discusses how these technologies bolster reproducibility and scalability and help reduce...
2025-10-0921 minCell & Gene: The PodcastInside Sanofi’s Genomic Medicine Vision with Mike Quigley, Ph.D.We love to hear from our listeners. Send us a message.On episode 112 of Cell & Gene: The Podcast, Michael Quigley, Ph.D., Chief Scientific Officer and Global Head of Research at Sanofi talks to Host Erin Harris about the establishment of Sanofi’s dedicated Genomic Medicine Unit (GMU). Dr. Quigley emphasizes in vivo delivery and process optimization to improve patient experience, scalability, and global access. They discuss the importance of partnerships with academia, industry, and regulators, and Dr. Quigley discusses how advances in AI are accelerating research efficiency, molecule optimization, and experimental design across Sanofi’s portfolio. He a...
2025-09-2524 minCell & Gene: The PodcastEngineering Off-the-Shelf Cell Therapies for Cancer & Autoimmune Disease with Ernexa Therapeutics' Sanjeev LutherWe love to hear from our listeners. Send us a message.On episode 111 of Cell & Gene: The Podcast, Host Erin Harris talks to Ernexa Therapeutics' President and CEO, Sanjeev Luther, about how the company is advancing cell therapy innovation for cancer and autoimmune disease through engineered induced pluripotent stem cell-derived mesenchymal stem cells (iMSCs). Luther shares how Ernexa’s synthetic, standardized, off-the-shelf iMSCs are designed to overcome historic hurdles in MSC therapy, including variability, scalability, and manufacturing complexity, by leveraging master cell banks, precise gene editing, and novel product engineering. He also shares insights into the process of...
2025-09-1120 minCell & Gene: The PodcastWhat Changes to FDA and CBER Mean for the Future of CGT with Daniela DragoWe love to hear from our listeners. Send us a message.This is Episode 4 of "FDA Fridays," a special series from Cell & Gene: The Podcast, Chief Editor Erin Harris speaks with regulatory affairs expert Daniela Drago, Partner, NDA Partners, about how shifting FDA and CBER priorities under the current administration could influence the trajectory of cell and gene therapy development. From the impact of leadership changes and evolving policy directives to the role of funding allocations and public health priorities, Drago sheds light on what CGT developers and sponsors should be watching most closely. She explores regulatory...
2025-08-2923 minCell & Gene: The PodcastInside CRISPR-GPT with Yuanhao QuWe love to hear from our listeners. Send us a message.In this episode of Cell & Gene Podcast episode, Host Erin Harris talks to Stanford School of Medicine Ph.D. student, Yuanhao Qu, about his work developing CRISPR-GPT, an AI-driven multi-agent system designed to automate genetic experimental design and data analysis, making CRISPR experiments more efficient and accessible, even for non-experts. Qu explains how CRISPR-GPT addresses key challenges such as guide design, delivery methods, off-target prediction, and protocol generation, and shares how collaborations with Princeton helped shape the tool’s architecture and evaluation. Qu also discusses Biomni, a...
2025-08-2820 minCell & Gene: The PodcastBarriers, Breakthroughs, and Building Access in Pediatric CGTs with Bambi Grilley, Ph.D.We love to hear from our listeners. Send us a message.This is Episode 3 of "FDA Fridays," a 4-week special series from Cell & Gene: The Podcast. Host Erin Harris talks to Bambi Grilley, Ph.D., Professor of Pediatrics and the Director of Clinical Research and Early Product Development for the Center of Cell and Gene Therapy (CAGT) at Baylor College of Medicine and Chief Regulatory Officer for ISCT, a leading expert at the forefront of pediatric cell and gene therapy. Dr. Grilley shares her wealth of experience and unique perspective on the most pressing barriers to accessing...
2025-08-2245 minCell & Gene: The PodcastDefining Product Roles and Navigating FDA Approval with Monika SwietlickaWe love to hear from our listeners. Send us a message.Episode 2 of FDA Fridays, the special series from Cell & Gene: The Podcast, features Host Erin Harris' discussion with regulatory expert Monika Swietlicka, Principal, Regulatory Strategy, Halloran Consulting Group about the key strategies and challenges in navigating FDA regulation for cell and gene therapies. Their conversation covers the importance of defining a therapy’s intended role (curative, chronic, or adjunctive) early in development, the different regulatory expectations based on disease context and patient population, and the crucial impact of unmet medical need on regulatory flexibility. Swietlicka emphasizes th...
2025-08-1538 minCell & Gene: The PodcastAdvancing Gene Therapy for FTD with Passage Bio's Dr. Will ChouWe love to hear from our listeners. Send us a message.In Episode 109 of Cell & Gene: The Podcast, Host Erin Harris talks to Will Chou, M.D., CEO of Passage Bio about the promise and challenges of developing gene therapies for frontotemporal dementia (FTD), a neurodegenerative disease with strong genetic underpinnings. Dr. Chou discusses the biological basis of FTD and the complex scientific, manufacturing, and regulatory hurdles that come with targeting the brain. They discuss the latest interim results from the upliFT-D study of Passage Bio’s PBFT02, including safety and tolerability findings, dose cohort comparisons, and th...
2025-08-1424 minCell & Gene: The PodcastFDA Fridays: Advancing Communication and Consistency in CGT Regulation with Kaye SprattWe love to hear from our listeners. Send us a message.This is Episode 1 of a special series of Cell & Gene: The Podcast, "FDA Fridays." This first episode features Host, Erin Harris' conversation with Kate Spratt, Strategic and Non-Clinical Regulatory Consultant at Spratt Advanced Cell & Gene Therapy Regulatory Consulting. Spratt emphasizes the importance of early and continuous engagement with regulatory authorities, especially through structured meetings like INTERACT and pre-IND sessions. Harris and Spratt cover CMC readiness, filing for RMAT/CIT, BLA approvals and regulatory expectations, and more. Subscribe to the podcast!Apple
2025-08-0847 minCell & Gene: The PodcastNavigating the Journey to Safer Stem Cell Therapies with Orca Bio's Nate FernhoffWe love to hear from our listeners. Send us a message.Cell & Gene: The Podcast Host, Erin Harris, talks to Orca Bio CEO and Co-Founder Nathaniel Fernhoff as he recounts the company’s origins and evolution, tracing its roots to pioneering stem cell research at Stanford University and Dr. Irv Weissman's lab. Seeking to create safer, more effective cures for blood cancers such as AML, ALL, and MDS, Orca Bio developed high-precision cell therapies that utilize purified regulatory T cells and stem cells to minimize complications, such as graft-versus-host disease. Orca Bio spun out of academia to es...
2025-07-3133 minCell & Gene: The PodcastRethinking Large Animal Models in Gene Therapy with Novartis' Ralf Schmid, Ph.D.We love to hear from our listeners. Send us a message.On this episode of Cell & Gene: The Podcast, Host Erin Harris talks to Ralf Schmid, Ph.D., Associate Director of Preclinical Research at Novartis Biomedical Research, about the evolving use of large animal models in gene therapy development. Dr. Schmid discusses the current reliance on non-human primates (NHPs), their growing logistical and ethical challenges, and the emerging interest in alternatives like genetically engineered pigs and sheep. He outlines key considerations around safety, biodistribution, and immunogenicity that still necessitate large-animal testin —particularly for CNS-targeted AAV therapies — and emph...
2025-07-1724 min
I Can Fit That InWhen Health Becomes a Catalyst for Change with Samatha Harris | #3What if your biggest health crisis became your greatest catalyst for change?Two-time Emmy-nominated TV host Samantha Harris skyrocketed from the glitz of Dancing with the Stars and Entertainment Tonight into a new spotlight — transforming her life after a shocking breast cancer diagnosis at just 40. Now a bestselling author, certified health coach, and wellness advocate, Samantha shares how she turned fear into fierce purpose, creating “Your Healthiest Healthy,” a movement inspiring thousands to clean up their lives inside and out.In this intimate conversation with host Erin Coupe, Samantha reveals:- The hidden toxins...
2025-07-1537 minCell & Gene: The PodcastGene Therapy for Inherited Retinal Diseases with Opus Genetics' Dr. George MagrathWe love to hear from our listeners. Send us a message.In this episode of Cell & Gene: The Podcast, George Magrath, CEO of Opus Genetics, shares with Host, Erin Harris, how the company is advancing gene therapies for inherited retinal diseases (IRDs), with a focus on LCA5, a rare and severe form of childhood blindness. Built on the foundational science of Dr. Jean Bennett and leveraging the legacy of Luxturna, Magrath shares how Opus is developing subretinal AAV-based therapies targeting seven distinct mutations. He also explains why gene therapy is particularly well-suited to IRDs, shares compelling early...
2025-07-0320 minCell & Gene: The PodcastExtracellular Vesicle Breakthroughs with Aegle Therapeutics' Dr. Gloria MatthewsWe love to hear from our listeners. Send us a message.In this episode of Cell & Gene: The Podcast, Host Erin Harris interviews Dr. Gloria Matthews, Chief Medical Officer of Aegle Therapeutics, a clinical-stage regenerative medicine company focused on developing therapies for rare and severe dermatologic and immunologic disorders. Dr. Matthews explains how Aegle is pioneering the use of extracellular vesicles (EVs) derived from mesenchymal stem cells, which offer advantages over traditional cell-based therapies. Their discussion highlights Aegle's lead product, AGLE-102 as well as the regulatory and manufacturing challenges of scaling EV-based therapies. They cover the broader...
2025-06-1915 minCell & Gene: The PodcastBridging Development and Regulation in CGT with Halloran Consulting Group's Monika SwietlickaWe love to hear from our listeners. Send us a message.On this episode of Cell & Gene: The Podcast, Host Erin Harris welcomes Monika Swietlicka, Principal, Regulatory Strategy at Halloran Consulting Group to discuss the key regulatory challenges facing cell and gene therapy companies. Swietlicka highlights manufacturing complexity and clinical trial design limitations. On gene editing, she notes that the FDA is focused on off-target effects and demands robust data, including functional validation. She emphasizes the importance of early definition of critical quality attributes and a strong comparability strategy to ensure product consistency. She also underscores the...
2025-06-0524 minCell & Gene: The PodcastHarnessing AI and Synthetic Biology for Cell Therapies with Generate:Biomedicines' Dr. Alex SnyderWe love to hear from our listeners. Send us a message.Host Erin Harris talks to Generate:Biomedicines' EVP of R&D, Dr. Alex Snyder about the convergence of AI, machine learning (ML), and synthetic biology in the development of next-generation therapies. They cover how AI is transforming drug discovery by enabling the rapid design and optimization of therapeutic candidates, particularly in complex fields like immuno-oncology and cell therapy. Dr. Snyder shares how that in the context of CAR-T therapies, AI-driven approaches are used to design and refine each component of the CAR construct. And, Dr. Snyder...
2025-05-2219 minCell & Gene: The PodcastRedefining Heart Failure Treatment with Precision Autologous Cell Therapy with BioCardia's Peter Altman, Ph.D.We love to hear from our listeners. Send us a message.In this episode of Cell & Gene: The Podcast, Host Erin Harris sits down with Peter Altman, Ph.D., CEO of BioCardia, to discuss the company’s evolution from a cardiac biotherapeutic delivery firm to a developer of autologous and allogeneic cell therapies for cardiovascular and pulmonary diseases. Altman highlights BioCardia’s CardiAMP program, a precision medicine approach that pre-screens patients based on their cell profiles to improve trial outcomes and reduce costs. He explains why no cardiac cell therapy has yet received FDA approval, citing challenges in d...
2025-05-0817 minCell & Gene: The PodcastCRI’s Response to NIH Cuts with Alicia Zhou, Ph.D.We love to hear from our listeners. Send us a message.In this episode of the Cell & Gene podcast, Host Erin Harris speaks with Alicia Zhou, Ph.D., CEO of the Cancer Research Institute (CRI), about CRI’s mission to advance cancer immunotherapy and the critical role of federal funding, particularly from the NIH, in supporting basic and translational cancer research. Dr. Zhou highlights CRI’s focus on funding early-stage science and clinical trials to move immunotherapy toward curing all cancers. She covers the serious implications of recent U.S. Government funding cuts, including NIH budget freezes and...
2025-04-2438 minCell & Gene: The PodcastRethinking CGT Biotech Growth & Investment with Audrey GreenbergWe love to hear from our listeners. Send us a message.On the 100th episode of Cell & Gene: The Podcast, Host, Erin Harris, sits down with Audrey Greenberg, Founder and CEO of AG Capital Advisors. Audrey is the award-winning executive, board director, and strategic advisor with a proven track record of launching, scaling, and successfully exiting multi-billion-dollar ventures. They explore the biggest challenges and opportunities facing CGT biotech leaders today; the funding crisis in biotech, the evolving investment landscape, and whether the traditional VC-driven model is still sustainable. They also examine what it really takes to scale...
2025-04-1028 minCell & Gene: The PodcastAdvancing Retinal Gene Therapy with Atsena Therapeutics' Dr. Kenji FujitaWe love to hear from our listeners. Send us a message.In this episode of Cell & Gene: The Podcast, Host Erin Harris dives into the world of retinal gene therapy with Kenji Fujita, M.D., Chief Medical Officer of Atsena Therapeutics. Atsena develops treatments for inherited retinal diseases, including X-linked retinoschisis (XLRS), a rare genetic condition that currently has no FDA-approved therapy. They talk through the impact of XLRS on patients, the challenges of gene delivery to the retina, and how Atsena’s AAV vector technology is designed to overcome these hurdles. They also discuss the significance of...
2025-03-2714 minCell & Gene: The PodcastHarnessing the Power of Cord Blood Tregs with Cellenkos' Dr. Simrit ParmarWe love to hear from our listeners. Send us a message.In this episode, Host Erin Harris sits down with Dr. Simrit Parmar, Founder of Cellenkos, to explore how the company is pioneering umbilical cord blood-derived Regulatory T cell (Treg) cell therapies for autoimmune and inflammatory diseases. Dr. Parmar shares the vision behind Cellenkos, the advantages of cord blood-derived Tregs over other sources, and how their CRANE technology platform enhances precision in targeting diseases. They also discuss key findings from their Phase 1b trial for CK0804, the challenges of scaling up off-the-shelf Treg therapies, and what’s ne...
2025-03-1334 minCell & Gene: The PodcastCGT Manufacturing: Distributed & Digital with Deloitte Consulting's Omkar Kawalekar, Ph.D.We love to hear from our listeners. Send us a message.Omkar Kawalekar, Ph.D., Senior Manager, NextGen Therapies Manufacturing & Supply Chain Lead, Deloitte Consulting joins Host Erin Harris to share his expert take on how distributed manufacturing models address capacity constraints and supply chain risks, the role of automation in reducing batch-to-batch variability, as well as the power of digital technologies in optimizing production processes. He also covers the key considerations for CGT companies when choosing between in-house manufacturing and CDMO partnerships, and much more.Subscribe to the podcast!Apple |
2025-02-2728 minCell & Gene: The PodcastInside Gene Therapies for Cardiac Care with Tenaya Therapeutics' Faraz AliWe love to hear from our listeners. Send us a message.In this episode, Erin Harris sits down with Faraz Ali, CEO of Tenaya Therapeutics, to explore the cutting-edge world of gene therapies for heart diseases. As Tenaya makes significant strides in developing innovative treatments, Ali shares insights on Tenaya's gene therapy platform, their in-house manufacturing capabilities, and the potential impact of their therapies on prevalent heart conditions. They also discuss the complexities of commercializing gene therapies, industry-wide developments, and Tenaya's roadmap for 2025. This conversation offers a unique glimpse into the future of cardiac care and the...
2025-02-1335 minCell & Gene: The PodcastThe Future of Adenovector-Based Therapies with Precigen's Helen Sabzevari, Ph.D.We love to hear from our listeners. Send us a message.Helen Sabzevari, Ph.D., President and CEO of Precigen, joins Host, Erin Harris to discuss how the company utilizes gorilla adenovirus vectors. These vectors offer significant advantages in delivering large genetic payloads, a crucial factor in developing effective gene therapies. Sabzevari also discusses Precigen's recent BLA submission for PRGN-2012, which includes Phase 1/2 pivotal study results where over 50% of patients achieved Complete Response and more than 85% experienced decreased surgical interventions.Subscribe to the podcast!Apple | Spotify |
2025-01-3026 min
Weaning It: A podcast for toddler nursing moms22. Breastfeeding, Business, and Farm Life: Chanti Zak's Extended Breastfeeding StoryThis episode is brought to you by the free Extended Breastfeeding Quiz.
Did you know there are 5 stages to toddler weaning? Curious to find out which stage you are in now? Go to www.nursingmamas.com/quiz to find out. You'll get tips based on exactly where you are in your toddler nursing journey today!
Episode Summary
Chanti Zak is an extended nursing mom of 3 and my personal quiz creating coach!
She is the creator of The Empathy Marketing Ecosystem and the Spill the Tea newsletter. She's a...
2025-01-231h 03Cell & Gene: The PodcastThe Future of NK Cell Therapy for Autoimmune Disease with Artiva Biotherapeutics' Christopher HoranWe love to hear from our listeners. Send us a message.Christopher Horan, Chief Technical Operations Officer, Artiva Biotherapeutics joins Cell & Gene: The Podcast Host, Erin Harris, to discuss the advantages natural killer (NK) cells have offer over T cells in terms of safety and efficacy for autoimmune disease. They take a deep dive into the key factors that make NK cells promising for ‘off-the-shelf’ cell therapy products. They cover Artiva's "manufacturing first" approach to enabling scalable NK cell production, and much more.Subscribe to the podcast!Apple | Spotify
2025-01-1624 minWeaning It: A podcast for toddler nursing moms21. Baby Led Weaning Isn't Weaning: Tips to Help Navigate Your Baby's Food With Continued NursingThis episode is brought to you by the Nursing Mama's Social Circle.
Do you feel lonely in your toddler nursing journey?
Do you wish you knew others going through it too?
The Social Circle is your virtual support group that includes a private app for chatting between 2 monthly live calls with Erin.
For $19/mo, it's the most cost effective way to meet with Erin and find your weaning tribe.
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Episode Summary
Erin br...
2025-01-0942 minCell & Gene: The PodcastLessons in Automation with Roswell Park Comprehensive Cancer Center's Christopher Choi, Ph.D.We love to hear from our listeners. Send us a message.Cell & Gene: The Podcast Host Erin Harris talks to Christopher Choi, Ph.D., MBA, SVP Industry Partnership, Director of GMP and Cell Manufacturing Facility, and Associate Professor of Oncology at Roswell Park Comprehensive Cancer Center about the Center's Buffalo, NY-based cell and gene therapy hub slated to open in early 2025. They cover the increasingly important role of automation and digital technologies in CGT manufacturing. Choi also offers his advice to new and emerging CGT biotechs on how to correctly tackle manufacturing as they begin their product...
2025-01-0214 minWeaning It: A podcast for toddler nursing moms20. From Prolapse to Triathlon: Kristine's Journey of Healing, Nursing, and Finding StrengthSummary
In this conversation, Kristine (@birth.injury.coach) shares her experiences with pregnancy, postpartum, nursing, and healing from prolapse.
She had a smooth pregnancy and worked out regularly; however, her birth was traumatic, resulting in tearing and hemorrhaging.
She had no expectations for nursing but was pleasantly surprised when her daughter latched right away.
Kristine experienced prolapse symptoms early postpartum, but with time, patience, and self-rehabilitation, she was able to heal.
She also managed to fit in training for a half Ironman triathlon while nursing, utilizing gym childcare and...
2024-12-191h 04Cell & Gene: The PodcastCan Gene Therapy Be the Solution for CHF with AskBio's Dr. Lothar RoessigWe love to hear from our listeners. Send us a message.Cell & Gene: The Podcast Host Erin Harris talks to Lothar Roessig, M.D., SVP, Integrated Product Team Lead, Congestive Heart Failure at Asklepios BioPharmaceutical, Inc. (AskBio) about the biggest challenges in developing gene therapies for cardiovascular diseases, specifically congestive heart failure (CHF). They discuss AB-1002, the gene therapy the company is developing for the treatment of CHF and why a gene therapy approach is significantly different from traditional therapies.Subscribe to the podcast!Apple | Spotify |
2024-12-1921 minWeaning It: A podcast for toddler nursing moms19. Handling the Holidays With Your Nursing ToddlerIf you are like Erin, then you may be feeling pressure to start holiday traditions that will be part of your children's lives for the next couple decades...
But your stressed out nurser may have other ideas.
In today's episode, Erin breaks down three common ways your breastfeeding toddler may responds to the changes around them this month, as well as 3 tips to handle nursing and weaning until the new year.
Q&A of the day: How much milk is too much??
Wins & Whines: Construction...
2024-12-0531 minCell & Gene: The PodcastInside a Dopamine-Restoring Cell Therapy for PD with BlueRock Therapeutics' Dr. Amit RahkitWe love to hear from our listeners. Send us a message.On this episode of Cell & Gene: The Podcast, Host Erin Harris, invites BlueRock Therapeutics' Dr. Amit Rhakit to take a deep dive into therapy options for Parkinson's disease (PD). They discuss how BlueRock's bemdaneprocel's mechanism of action differs from traditional PD treatments. They cover the limitations of current PD medications, how cell therapies might offer a different approach to long-term symptom management, and how BlueRock is doing traditional dopamine replacement therapy differently.Subscribe to the podcast!Apple | Spotify
2024-12-0531 minCell & Gene: The PodcastGlobalization's Impact on Patient Access with ARM's COO, Rita Johnson-GreeneWe love to hear from our listeners. Send us a message.Rita Johnson-Greene, COO at Alliance for Regenerative Medicine (ARM) joined Cell & Gene: The Podcast Host, Erin Harris, on site during 2024 Meeting on the Mesa to record their discussion. Johnson-Greene shared information about the Joint Clinical Assessment (JCA) in Europe and its potential impact on cell and gene therapies, how globalization impacts patient access, an update on ARM's Grow Internship Program, as well as a few key takeaways from the event that sector professionals can anticipate impacting the CGTs in the next 12 months and beyond....
2024-11-2121 minCell & Gene: The PodcastImproving TCR T-Cell Persistence and Efficacy with Adaptimmune's Dennis WilliamsWe love to hear from our listeners. Send us a message.On this episode of Cell & Gene: The Podcast, Host Erin Harris talks to Dennis Williams, Senior Vice President of Late Stage Development at Adaptimmune. Williams shares valuable insights into the groundbreaking world of TCR T-cell therapies, with a particular focus on the TECELRA trial. The trial led to the FDA approval of Tecelra, marking a significant milestone as the first engineered T-cell therapy for solid tumors. Williams delves into the complexities of developing this innovative treatment for synovial sarcoma, a rare and aggressive form of soft-tissue...
2024-11-0720 minWeaning It: A podcast for toddler nursing moms18. From Extended Breastfeeding to Double Mastectomy: A Mom's Journey of ResilienceOctober is Breast Cancer Awareness month, and so on this episode of Weaning It, Erin sits down with her friend Caitlin LoCascio-King who is a veteran breastfeeding mom of 4, a lawyer and business woman who had a double mastectomy earlier this year.
Caitlin shares her four different breastfeeding experiences, two of which extended beyond a year.
She then explains how her family history of cancer prompted her to begin getting routine mammograms and breast MRIs before the age of 40 and how doing so resulted in a double mastectomy.
She shares her health journey o...
2024-10-241h 09Cell & Gene: The PodcastLive from ARM's Meeting on the Mesa with Kiji Therapeutics' Dr. Miguel ForteWe love to hear from our listeners. Send us a message.This episode of Cell & Gene: The Podcast was recorded on site during ARM's 2024 Meeting on the Mesa in Phoenix. Tune in to hear Host Erin Harris talk to Miguel Forte, M.D., Ph.D., CEO of Kiji Therapeutics, President of ISCT, and Executive Committee Member of ARM about Kiji's clinical plan and why iPSC-MSC therapy for inflammatory diseases shows great promise. They also cover this year's conference and what to expect during and after the event.Subscribe to the podcast!Apple
2024-10-2425 minCell & Gene: The PodcastPioneering Next-Gen TCR Therapies in Solid Tumors with Neogene Therapeutics’ Carsten Linnemann, Ph.D.We love to hear from our listeners. Send us a message.Carsten Linnemann, Ph.D., CEO of Neogene Therapeutics and Head of Oncology Cell Therapy Clinical Development, AstraZeneca joins Cell & Gene: The Podcast’s Erin Harris to discuss T-cell receptor (TCR) therapies for solid cancers. They talk through key challenges and opportunities in developing TCR therapies targeting neoantigens as well as the potential benefits of TCR-T therapies for cancer treatment. Linnemann shares his thoughts on the future landscape of cell therapy in oncology and beyond. Previous episodes of Cell & Gene: The Podcast have focused on TCR therapies, in...
2024-10-1014 minWeaning It: A podcast for toddler nursing moms17. Is Gentle Parenting Too Hard on Moms? Debunking the Myth of Perfection + How to Handle Child HittingErin critiques a Motherly article on gentle parenting and questions if a gentle parenting backlash is on the horizon.
Like most fads and trends, gentle parenting can be taken to the extreme and be so distorted it no longer resembles its original form.
She provides 3 tips to decide if parenting advice is a good fit for you, and when to see additional help.
Next, she discusses how to apply gentle parenting techniques when your toddler hits, and how to look at their hitting through a new lens (spoiler: they're not mad, they're scared).
2024-10-0347 minCell & Gene: The PodcastOptogenetics for Vision Restoration with Ray Therapeutics' Paul BresgeWe love to hear from our listeners. Send us a message.Ray Therapeutics' Co-Founder and CEO, Paul Bresge, joins Host Erin Harris to talk about optogenetics and how the company’s optogenetics approach differs from other gene therapies on the market developed to restore vision in retinal diseases like retinitis pigmentosa.Subscribe to the podcast!Apple | Spotify | YouTube Visit my website: Cell & Gene Connect with me on LinkedIn
2024-09-2522 minWeaning It: A podcast for toddler nursing moms16. Fit4Mom: Empowering Prenatal and Postpartum Fitness While Nursing with Ciera GreeneIn this conversation, Ciera Greene discusses her experience as a toddler nursing mom and her role as the owner of Fit4Mom South Orange County, a fitness program for pre and postnatal moms.
She shares her thoughts on extended nursing, the emotional connection it creates, and the privilege of being able to provide nourishment and care for her child.
Ciera also talks about the benefits of Fit4Mom, including the opportunity to connect with other moms, the focus on mind-body connection, and the specialized training for prenatal and postpartum fitness.
She emphasizes that...
2024-09-1948 minCell & Gene: The PodcastA New Approach to Genome Engineering with Tessera Therapeutics' Dr. Michael SeverinoWe love to hear from our listeners. Send us a message.Tessera Therapeutics' CEO, Dr. Michael Severino, joins Host Erin Harris to discuss Gene Writing, the biotech's genome engineering technology that writes therapeutic messages into the genome to treat diseases at their source. Severino discusses why delivery has always been a challenge for gene editing technologies and why Gene Writing is different when it comes to efficient delivery.Subscribe to the podcast!Apple | Spotify | YouTube Visit my website: Cell & Gene ...
2024-09-1228 minWeaning It: A podcast for toddler nursing moms15. Loneliness in NursingEver feel lonely in your extended breastfeeding journey?
I polled my audience on Instagram, and here were the results:
- 53% of respondents feel lonely in toddler nursing all the time
- 34% sometimes
- 13% don't really feel lonely
Sadly, it is extremely common, especially as an extended nurser to feel isolated and alone. Some of you may not know another toddler nursing mom, and others may be navigating judgement from others for your decision to continue nursing.
In today's...
2024-09-0537 minCell & Gene: The PodcastScaling Allo with Allogene Therapeutics' Dr. Zachary RobertsWe love to hear from our listeners. Send us a message.Allogene Therapeutics' EVP of R&D and CMO, Dr. Zachary Roberts, penned an original article for Cell & Gene titled, The Path Forward for CLL is Allogeneic. In his article, Dr. Roberts explains that chronic lymphocytic leukemia (CLL) is the most common leukemia in the U.S. And that while CLL remains a disease that is managed, it is not one that is often cured. In this episode, Host Erin Harris follows up Roberts' article with in-depth questions around existing issues with current CAR T approaches, "auto...
2024-08-2925 minWeaning It: A podcast for toddler nursing moms14. Navigating Sobriety and Motherhood: A Conversation with Abbie KnaptonIn this episode of Weaning It, Erin sits down with Abbie Knapton; a mom in longterm recovery from addiction, an expressive arts trainer, certified peer recovery specialist, and mom of two extended nursers.
Abbie discusses the intersection of sobriety and motherhood and opens up about her journey to sobriety before kids and how it has shaped her parenting experience. We delve into the pressures of "mommy wine culture" and explore the underlying unmet needs of moms that play into it. Whether you're navigating similar challenges or simply interested in a candid conversation about the realities of motherhood...
2024-08-1556 minWeaning It: A podcast for toddler nursing moms13. It's World Breastfeeding Week!New to the pod? Welcome! I invite you to take the free Extended Breastfeeding Quiz to learn which stage of toddler nursing you are currently in, as well as to provide you with specific tips based on where you are in your nursing and weaning journey. Click HERE to get started!
August 1st kicks off World Breastfeeding Week and National Breastfeeding Month. In this episode, Erin discusses:
- The themes of each
- Why advocacy matters
- Her own experience re-entering the workforce
- Why making...
2024-08-0129 minCell & Gene: The PodcastIdentifying Drug Development Opportunities for DMD with CureDuchenneWe love to hear from our listeners. Send us a message.Debra Miller, CEO and Founder and Dr. Michael Kelly, Chief Scientific Officer at CureDuchenne talk to Host Erin Harris about the FDA approval for the expansion to the label indication for ELEVIDYS from Sarepta Therapeutics as well as how CureDuchenne works with various biotechs developing gene therapies for Duchenne muscular dystrophy (DMD). Miller and Kelly also share their advice and recommendations for companies developing drugs for DMD - while much progress has been made, more innovation is needed.Subscribe to the podcast!...
2024-08-0129 minWeaning It: A podcast for toddler nursing moms12. "When We're Ready" - An Interview with Kirsty DuncanKirsty Duncan is a children’s picture book author that lives in Cheshire, UK.
Her latest picture book, "When We're Ready" celebrates longer-term breastfeeding and co-sleeping and has been endorsed by Emma Pickett and Lucy Webber, both of which are highly respected IBCLC Lactation Consultants in their field.
To purchase When We're Ready, head over to www.kirstyduncanwrites.com and enter promo code WEANINGIT at checkout for 10% off your total purchase!
The book follows Kirsty and her daughters breastfeeding journey, with relatable milestones throughout and is the first I have enco...
2024-07-1859 minCell & Gene: The PodcastTackling "The Delivery Problem" of Gene Editing-Based Medicines with Mammoth Biosciences' Lucas HarringtonWe love to hear from our listeners. Send us a message.Lucas Harrington, Co-Founder and Chief Scientific Officer of Mammoth Biosciences, joins Erin Harris to shed light on the biotech's proprietary ultracompact CRISPR systems to develop potential long-term curative therapies for patients with life-threatening and debilitating diseases. They discuss why in vivo delivery continues to be a bottleneck against the clinical advancement of gene-editing-based medicines and what ultracompact CRISPR systems are designed to do.Subscribe to the podcast!Apple | Spotify | YouTube Visit...
2024-07-1821 minWeaning It: A podcast for toddler nursing moms11. The Emotional Cycle of the Extended Breastfeeding MomDo you struggle with swinging between loving extended nursing and feeling touched out, burnt out, and ready to wean Now? Then this episode is for you.
In this solo show, Erin breaks down the emotional cycle of the extended breastfeeding mom - a 3 phase cycle she has created based on listening to hundreds of toddler nursing moms discuss their nursing journeys.
She explains what they phases are and how to break the cycle for good.
Go to www.nursingmamas.com/blog/cycle to see the visual supplement of the emotional cycle.
...
2024-07-0443 minCell & Gene: The PodcastTILs for the Treatment of Solid Tumors with KSQ Therapeutics' Micah Benson, Ph.D.We love to hear from our listeners. Send us a message.KSQ Therapeutics' CSO, Micah Benson, Ph.D., joins Erin Harris to discuss how Tumor-Infiltrating Lymphocytes (TILs) as a treatment modality have the potential to treat a variety of solid tumor types. Benson explains KSQ's Phase 1/2 clinical study, KSQ-001EX, which consists of TILs in which the SOCS1 gene is inactivated by CRISPR/Cas9 gene editing. In addition to solid tumors, Benson also addresses the therapeutic potential for autoimmune disease.Subscribe to the podcast!Apple | Spotify |
2024-07-0435 minCell & Gene: The PodcastSynthetic Biology and Programmable mRNA with Strand Therapeutics' Jake BecraftWe love to hear from our listeners. Send us a message.Strand Therapeutics' CEO and Co-Founder Jake Becraft joins Erin Harris to discuss genetic regulation and how the company's programmable mRNA constructs combine genes for self-replication derived from RNA viruses with genetically programmed logic circuits that control the location, timing, and intensity of expression of therapeutic proteins within the patient’s body, enabling precise and controlled delivery. They also cover the role synthetic biology plays to genetically program mRNA to deliver therapies.Subscribe to the podcast!Apple | Spotify...
2024-06-2027 minWeaning It: A podcast for toddler nursing moms9. I'm Turning 40 Tomorrow! Saying Goodbye to My Baby-Making EraIn this episode of Weaning It, Erin reflects on her biggest life lessons of her 30s and what she is looking forward to most in her 40s.
Becoming a mom first at 32, and again at 35, the last 10 years have had major changes to every aspect of life - marriage, career, and parenthood. Tag along as Erin deep dives the 5 biggest takeaways of her baby-making era.
Sponsored by: The Extended Breastfeeding Quiz
Extended breastfeeding has 5 stages. Which are you in now? Take the FREE Quiz to find out!
2024-06-0643 minCell & Gene: The PodcastDeveloping an mRNA Therapy for DMD with Elixirgen Therapeutics' Aki KoWe love to hear from our listeners. Send us a message.Elixirgen Therapeutics' Aki Ko joins Erin Harris to detail the company's Bobcat mRNA therapeutic and how it differs from traditional exon-skipping drugs and AAV-microdystrophin in treating DMD. Regarding delivery, Ko explains the advantage of the mRNA approach over the AAV approach.Subscribe to the podcast!Apple | Spotify | YouTube Visit my website: Cell & Gene Connect with me on LinkedIn
2024-06-0614 minWeaning It: A podcast for toddler nursing moms7. 3 Common Bedtime Mistakes Toddler Breastfeeding Moms Make (and how to fix them)This episode is brought to you by the Abiie Beyond Junior High Chair. Do you have a toddler that is too big for your old high chair, but wiggles around in the adult chair because they are now too low for the table? Do you struggle with daily spills that leave stains on your furniture? Then this toddler chair is perfect for you. The seat and foot rest are fully adjustable, the tray can be removed so it converts into an extra seat at your table, and it is the nicest looking high chair around. We've used two for...
2024-05-0240 minCell & Gene: The PodcastInside BlueRock Therapeutics' Parkinson's Disease Trial with Dr. Ahmed EnayetallahWe love to hear from our listeners. Send us a message.BlueRock Therapeutics' SVP Head of Development, Dr. Ahmed Enayetallah, joins Cell & Gene: The Podcast Host, Erin Harris, to discuss the company's phase I clinical trial for Parkinson’s disease, which continues to show positive trends at 18 months. They cover the important role induced pluripotent stem cells' (iPSCs) play in the trial, and they also discuss the company's investigational cell therapy, bemdaneprocel.Listen and subscribe so you never miss an episode!Subscribe to the podcast!Apple | Spotify...
2024-04-2529 min
The Feminist Mom PodcastMoms Can't Win: Examining Societal Messages Around Breastfeeding with Erin HarrisErin Harris is a virtual lactation educator, creator of Nursing Mamas, and a veteran nursing mom of 4 ½ years. She is also the host of the podcast, Weaning It: A Podcast for Toddler Nursing Moms. She combines her two Master's Degrees in Health and Family communication, lactation knowledge, and personal nursing experience to focus on the parent-toddler nursing relationship. Through online courses and consults she helps extended breastfeeding parents set breastfeeding boundaries and wean gently so they can keep the bond without the burnout. In this conversation, the Erins discuss the challenges and ex...
2024-04-231h 05Cell & Gene: The PodcastReducing the Disease Burden of AML with Vor Bio's Dr. Robert AngWe love to hear from our listeners. Send us a message.In 2021 on Episode 13, Vor Bio’s President and CEO, Dr. Robert Ang shared data about the company’s lead engineered hematopoietic cell (eHSC) product candidate. Dr. Ang is back to talk to Cell & Gene: The Podcast Host, Erin Harris, about how Vor has treated 8 patients demonstrating clinical proof of concept and is also in the clinic with a CAR-T that could be used in combination with shielded stem cell transplants. They also talk through Vor’s decision to build an internal cell therapy manufacturing facility co-located with t...
2024-04-1123 minWeaning It: A podcast for toddler nursing moms5. Gentle parenting defined (and how to apply it to toddler breastfeeding)This episode is brought to you by live The Gentle Toddler Weaning Seminar. This live session covers everything in Erin's Gentle Toddler Weaning Course, but with the engagement of fellow toddler breastfeeding moms, and a special Q&A session with Erin following the seminar. The webinar will be on Wednesday April 17th, 2024 @ 10am PT // 1pm ET via Zoom.
In this episode Erin covers:
- What gentle parenting is (and isn't)
- Concrete gentle parenting strategies to use with your breastfeeding toddler to help manage meltdowns and increase connection
- What to...
2024-04-0432 minCell & Gene: The PodcastReducing Toxicities in Allogeneic Cell Therapies with Orca Bio's Dr. Scott McClellanWe love to hear from our listeners. Send us a message.Orca Bio's CMO, Dr. Scott McClellan, joins Erin Harris on this episode of Cell & Gene: The Podcast to discuss how and why toxicities continue to stymie allogeneic cell therapies. They cover Orca Bio's plan to potentially lowering the risk of GvHD as well as Orca-T, the investigational high-precision allogeneic cell therapy being evaluated in clinical trials for the treatment of multiple hematologic malignancies.Subscribe to the podcast!Apple | Spotify | YouTube Visit...
2024-03-2819 minCell & Gene: The PodcastInside Cellular Rejuvenation Therapies for Age-Related Diseases with Life Biosciences' Sharon Rosenzweig-Lipson, Ph.D.We love to hear from our listeners. Send us a message.On this episode of Cell & Gene: The Podcast, Host Erin Harris talks to Life Biosciences' CSO, Sharon Rosenzweig-Lipson, Ph.D., about the Boston-based biotech's cellular rejuvenation therapies for the treatment of age-related diseases. They cover Life Biosciences' lead program, a gene therapy called OSK that is being advanced in two optic neuropathies – a rare eye disease of aging called non-arteritic anterior ischemic optic neuropathy (NAION) and glaucoma. They also cover they why behind gene therapy as a modality, as well as Life Biosciences' partnership with Forge Bi...
2024-03-1417 minWeaning It: A podcast for toddler nursing moms3. Re-Thinking Extended Breastfeeding SuccessThis episode is brought to you by The Gentle Toddler Weaning Course. Use Promo code "PODCAST" for $10 off.
Welcome to episode 3! Erin covers the following:
- How to think beyond time and length of breastfeeding as a measurement of success.
Download the free guide to assess your REAL breastfeeding goal HERE.
- Q&A question of the day: Nikki asks, "Anyone still breastfeeding at 3 years and struggling to get your energy and body back without taking supplements that are not safe while breastfeeding? Hormone imbalances and lack of vitamins making it...
2024-03-0738 minCell & Gene: The PodcastThe Future of Rare Diseases with The Jackson Laboratory’s Rare Disease Translational Center's Cat LutzWe love to hear from our listeners. Send us a message.Rare Disease Day is February 29, 2024, and in honor of this important day, Cell & Gene: The Podcast Host Erin Harris sits down with Jackson Laboratory’s (JAX) Rare Disease Translational Center (RDTC)'s VP, Cat Lutz. They discuss RDTC's mission, the specific qualifications that make up a rare disease, how the study of rare diseases can potentially advance progress in common diseases, and much more. Subscribe to the podcast!Apple | Spotify | YouTube Vis...
2024-02-2927 minWeaning It: A podcast for toddler nursing moms2. Breastfeeding a 5 year old with Erin SpahrErin Spahr is an extended breastfeeding mom of 2 boys - the first nursed for 3 years, and the second for 5, for a combined total of 8 years of breastfeeding! We dive into her experiences, including strategies for night weaning, handling public nursing a toddler, the perks of toddler nursing, and what she used to help guide her sons to the finish line to successfully wean on their terms.
Professionally, Erin is a licensed therapist, mother, intersectional feminist, podcast host, and maternal mental health advocate. Erin uses a feminist lens in her work with mothers and strives to help mothers...
2024-02-271h 00Weaning It: A podcast for toddler nursing moms1. On-Demand vs Gentle Toddler NursingWelcome to the first episode of Weaning It! To get started, Erin breaks down the difference between on-demand breastfeeding, gentle toddler breastfeeding, and gentle weaning.
She also answers listener Joanna's question about dealing with all or nothing kids. How do you commit to giving up a feed when you're still on the fence about weaning yourself?
Want to learn more about what stage of extended nursing you are in now (and steps to get where you want to be)? Go to www.nursingmamas.com/quiz to take Erin's free...
2024-02-1722 minCell & Gene: The PodcastInside Yescarta's Reduced Median Turnaround Time with Kite, a Gilead company's Christopher McDonaldWe love to hear from our listeners. Send us a message.On this episode of Cell & Gene: The Podcast, Christopher McDonald, Global Head of Technical Operations at Kite, a Gilead company, talks to Host Erin Harris about Kite's recent FDA approval of manufacturing process change resulting in reduced median turnaround time for Yescarta. They talk through the most significant steps Kite took to reach this approval, lessons learned from having worked with the FDA, scaling up technologies for cell therapy manufacturing, and more. Subscribe to the podcast!Apple | Spotify
2024-02-1520 minWeaning It: A podcast for toddler nursing momsWeaning It: Trailer!New free episodes of Weaning It drop every 1st and 3rd Thursday on all podcasting platforms, including Spotify, Apple Podcasts, and Google Podcasts.
If you like what you hear, please click that Follow/Subscribe button so you'll be the first to see new episodes. And also, please leave a rating/review! It will help other extended nursing moms find the show.
You can also head to www.nursingmamas.com/podcasts to listen to all episodes and get the show notes.
Do you have a...
2024-02-1303 minCell & Gene: The PodcastPricing, Value, And Access of CGTs With The Dedham Group's Jennifer Klarer, M.Sc.Eng.We love to hear from our listeners. Send us a message.The Dedham Group's Jennifer Klarer, M.Sc.Eng., Partner and Head of Cell & Gene Therapy, joins Erin Harris on this episode of Cell & Gene: The Podcast for a deep dive into pricing and value for CGTs. Klarer shares a detailed breakdown of the most misunderstood aspects of cell and gene therapy pricing, value, and affordability. She details how manufacturers can get ahead of addressing time to treatment issues typically experienced at launch. They cover obtaining adequate investment dollars, and much more. Subscribe to the p...
2024-02-0137 minCell & Gene: The PodcastBreaking Down Solid Tumors with Triumvira Immunologics' Dr. Paul LammersWe love to hear from our listeners. Send us a message.Paul Lammers, M.D., M.Sc., CEO of Triumvira Immunologics joins Cell & Gene: The Podcast to talk to Host Erin Harris about TAC, the company's proprietary T cell Antigen Coupler, which has both autologous and allogeneic approaches. They also discuss targeting relapsed or refractory HER2-positive solid tumors and CLDN18.2-positive solid tumors. And they cover a realistic outlook on the evolution of cancer treatment.Subscribe to the podcast!Apple | Spotify | YouTube
2024-01-1821 minCell & Gene: The Podcast4 Keys to Allo in 2024 with Poseida Therapeutics' Kristin Yarema, Ph.D.We love to hear from our listeners. Send us a message.Kristin Yarema, Ph.D., CEO, Poseida Therapeutics sits down with Cell & Gene: The Podcast Host Erin Harris to discuss four of the biggest challenges the CGT sector faces when it comes to the development of off-the-shelf therapies. Kristin shares how 2024 might see some real progress in allogeneic therapies. Subscribe to the podcast!Apple | Spotify | YouTube Visit my website: Cell & Gene Connect with me on LinkedIn
2024-01-0431 minCell & Gene: The PodcastCell Therapy For Corneal Endothelial Dystrophies With Aurion Biotech's Greg KunstWe love to hear from our listeners. Send us a message.For this third and final episode recorded at ARM's 2023 Meeting on the Mesa, Cell & Gene: The Podcast Host, Erin Harris, sat down with Greg Kunst, president, CEO, and Board member at Aurion Biotech. Listen in as they discuss the cell therapy used to treat corneal endothelial disease and how Greg navigated the event as a first-timer attending Meeting on the Mesa.Subscribe to the podcast!Apple | Spotify | YouTube Visit my website...
2023-12-2113 minCell & Gene: The PodcastOvercoming the Limitations of CAR T-Cell Therapy with Vittoria Bio's Nick Siciliano, Ph.D.We love to hear from our listeners. Send us a message.Vittoria Biotherapeutics’ CEO, Nick Siciliano, joins Erin Harris on this episode of Cell & Gene: The Podcast to discuss the company's mission to expand the applications for CAR-based therapeutics by employing novel cell engineering and gene editing technologies.Subscribe to the podcast!Apple | Spotify | YouTube Visit my website: Cell & Gene Connect with me on LinkedIn
2023-12-0717 minCell & Gene: The PodcastGene Therapy Deals, Collaborations, & Partnerships with Astellas' Richard WilsonWe love to hear from our listeners. Send us a message.Richard Wilson, Senior Vice President, Primary Focus Lead, Genetic Regulation at Astellas sat down with Cell & Gene: The Podcast's Erin Harris at ARM's 2023 Meeting on the Mesa to discuss the gene therapy deal making landscape as well as Astellas' recent deals and collaborations. They also discussed Astellas' strategic approach since having acquired Audentes back in 2020.Subscribe to the podcast!Apple | Spotify | YouTube Visit my website: Cell & Gene Connect with...
2023-11-2125 minCell & Gene: The PodcastThe Promise of AAV Gene Therapy with REGENXBIO's Ken MillsWe love to hear from our listeners. Send us a message.Ken Mills, CEO, President, and Director at REGENXBIO joins Erin Harris for this episode of Cell & Gene: The Podcast to discuss the company's progress with its Phase I/II Affinity Duchenne trial of RGX-202 for the treatment of Duchenne Muscular Dystrophy. They discuss the future of AAV gene therapy as well as achieving scalability with consistent yield and product purity in gene therapy manufacturing.Subscribe to the podcast!Apple | Spotify | YouTube ...
2023-11-0928 minCell & Gene: The PodcastInside 2023 Meeting on the Mesa with ARM's COO, Rita Johnson-GreeneWe love to hear from our listeners. Send us a message.Alliance for Regenerative Medicine's COO, Rita Johnson-Greene, joined Cell & Gene: The Podcast host, Erin Harris, in person at the 2023 Meeting on the Mesa to discuss this year's event. Johnson-Greene also shared what's ahead for 2024 as the event heads to a new location. They discussed major topics and trends at the event as well as ARM's GROW internship program.Subscribe to the podcast!Apple | Spotify | YouTube Visit my website: Cell & Gene
2023-10-2616 minCell & Gene: The PodcastThe Future of Cell and Organ Transplantation in Treating T1D with Dr. Camillo RicordiWe love to hear from our listeners. Send us a message.A pioneer and an icon in diabetes research, Camillo Ricordi, M.D., is the Professor of Surgery, Director of Cell Transplant Center and Director Emeritus of the Diabetes Research Institute at the University of Miami Miller School of Medicine, Florida (UM-DRI). He joins Cell & Gene: The Podcast's Erin Harris to discuss the biggest and most troubling challenges facing the treatment of Type 1 Diabetes (T1D). They also discuss the future of cell and organ transplantation in treating T1D as well as the latest innovations in...
2023-10-1218 minCell & Gene: The PodcastIn Vivo CAR T-Cell Therapeutics With Umoja Biopharma's Dr. Andrew ScharenbergWe love to hear from our listeners. Send us a message.Umoja Biopharma's CEO, Andy Scharenberg, M.D., joins Cell & Gene: The Podcast's Erin Harris to discuss the evolution of allogeneic, in vivo CAR-T cell therapeutics. They discuss The Climb, or The Colorado Laboratory and Innovation Manufacturing Building, which is Umoja’s lentiviral vector development and manufacturing facility. They also cover recent progress in lentiviral vector manufacturing.Subscribe to the podcast!Apple | Spotify | YouTube Visit my website: Cell & Gene Connect wi...
2023-09-2830 minCell & Gene: The PodcastInside Genome Editing with CBER's Dr. Peter MarksWe love to hear from our listeners. Send us a message.The FDA's Center for Biologics Evaluation and Research (CBER)'s Dr. Peter Marks makes his second appearance on Cell & Gene: The Podcast. This time Dr. Marks talks to Host, Erin Harris, about base editing and prime editing and their potential to meet unmet medical need. They discuss what clinical holds say about the FDA’s views on gene editing. They also discuss heritable genome editing.Subscribe to the podcast!Apple | Spotify | YouTube ...
2023-09-1425 minCell & Gene: The PodcastThe Future of CAR-T with Bristol Myers Squibb's Lynelle HochWe love to hear from our listeners. Send us a message.As SVP Cell Therapy Franchise Lead at Bristol Myers Squibb, Lynelle Hoch leads her team to bring more curative cell-based therapies to patients. She joins Cell & Gene: The Podcast's Host, Erin Harris, to discuss the near-term future of CAR-T. They also take a deep dive into the various innovations and patient access progress being made in both solid tumors and hematologic malignancies in the CGT sector at large as well as at Bristol Myers Squibb.Subscribe to the podcast!Apple |
2023-08-3125 minCell & Gene: The PodcastThe Promise of Genome Editing with Caribou Biosciences' Rachel Haurwitz, Ph.D.We love to hear from our listeners. Send us a message.On this episode of Cell & Gene: The Podcast, Rachel Haurwitz, Ph.D., CEO at Caribou Biosciences joins Host Erin Harris to discuss the evolution of genome editing, its present state, as well as its undeniable potential. They also discuss Caribou's chRDNA genome editing technology and how it differs from CRISPR-Cas9.Subscribe to the podcast!Apple | Spotify | YouTube Visit my website: Cell & Gene Connect with me on LinkedIn
2023-08-1723 minCell & Gene: The PodcastFocus Areas For Cell Therapy With Bristol Myers Squibb's Stephan Krause, Ph.D.We love to hear from our listeners. Send us a message.In June 2023, PDA held its Advanced Therapy Medicinal Products Conference in Baltimore, MD. At the conference, Stephan Krause, Ph.D., Executive Director, AS&T, CT Global Quality at Bristol Myers Squibb, sat down with Cell & Gene: The Podcast Host Erin Harris to discuss the event's major themes and topics as well his focus areas for cell therapy in 2023 and beyond.Subscribe to the podcast!Apple | Spotify | YouTube Visit my website: Cell...
2023-08-0319 minCell & Gene: The PodcastThe Intersection Of RNA, AI, And Synthetic Biology With Shape Therapeutics' Dr. Francois VigneaultWe love to hear from our listeners. Send us a message.Dr. Francois Vigneault, Co-Founder, President, and CEO at Shape Therapeutics joins Cell & Gene: The Podcast's Erin Harris to discuss how RNA technologies are shaping the future of gene therapy. They also discuss AI's role in gene therapy as well as the how the CGT sector is benefiting from RNA, AI, and synthetic biology.Subscribe to the podcast!Apple | Spotify | YouTube Visit my website: Cell & Gene Connect with me on...
2023-07-2029 min
Super Entrepreneurs PodcastDiscovering Passion and Embracing Fulfillment: A Deep Dive into Mindful Living with Erin HarrisWelcome to our illuminating podcast episode, "Discovering Passion and Embracing Fulfillment: A Deep Dive into Mindful Living with Erin Harris." In this engaging conversation, we explore Erin's unique approach to identifying and pursuing his passion and how that has led to a deeply fulfilling life. Erin, an innovative artist, shares his philosophy on work, happiness, and personal satisfaction. From tuning out the noise and focusing on self-discovery to cultivating a sense of contentment in everyday life, Erin offers valuable insights and advice. Whether you're seeking to find your own passion or just searching for a more balanced and joyful...
2023-07-1220 minCell & Gene: The PodcastInside Prime Editing with Prime Medicine's Dr. Andrew AnzaloneWe love to hear from our listeners. Send us a message.Dr. Andrew Anzalone, Head of the Prime Editing Platform and Scientific Co-Founder of Prime Medicine joins Cell & Gene: The Podcast to talk with Host Erin Harris about prime editing - what it is and why it is a major technological advancement in gene editing. Anzalone explains why prime editing has a broad applicability for different tissue and cell types to be used in different therapeutic applications.Subscribe to the podcast!Apple | Spotify | YouTube
2023-07-0624 minCell & Gene: The PodcastNavigating CMC Challenges with Parenteral Drug Association's Glenn WrightWe love to hear from our listeners. Send us a message.Glenn Wright, President and CEO of Parenteral Drug Association (PDA), sat down with Cell & Gene: The Podcast's Erin Harris at the 2023 PDA ATMP conference to discuss not only the conference's theme, “Navigating Through CMC Challenges,” but also Wright's take on CGT manufacturing strategy based on his years in industry. Wright shares his insight on the past, present, and future of the cell and gene therapy space.Subscribe to the podcast!Apple | Spotify | YouTube
2023-06-2224 minCell & Gene: The PodcastTargeting Oncogenic Drivers for Solid Tumor Cancers with Affini-T Therapeutics' Dr. Jak KnowlesWe love to hear from our listeners. Send us a message.Affini-T Therapeutics combines a validated TCR discovery platform with synthetic biology switches to attack tumor biology at its root cause. Co-Founder, CEO, and President Dr. Jak Knowles joins Cell & Gene: The Podcast Host Erin Harris to discuss how the company engineers immune cells to target oncogenic driver mutations, such as KRAS, the most prevalent oncogenic driver mutation in solid tumors, to minimize potential tumor escape mechanisms.Subscribe to the podcast!Apple | Spotify | YouTube
2023-05-2523 minCell & Gene: The PodcastTJU's Jefferson Institute for Bioprocessing's Impact on CGT with Parviz ShamlouWe love to hear from our listeners. Send us a message.Parviz Shamlou, Vice President and Executive Director at Thomas Jefferson University joins Cell & Gene: The Podcast to talk to Host Erin Harris about Jefferson Institute for Bioprocessing (JIB), the full-service development and training organization specializing in biopharmaceuticals and biologics. Shamlou explains how JIB will move forward cell and gene therapies as well as JIB’s partnership with NIBRT (National Institute for Bioprocessing Research & Training), and much more.Subscribe to the podcast!Apple | Spotify | YouTube
2023-05-1142 minCell & Gene: The PodcastComputational Biology's Role In Gene Therapy With Kriya Therapeutics' Dr. Shankar RamaswamyWe love to hear from our listeners. Send us a message.Shankar Ramaswamy, M.D., CEO & Co-Founder, Kriya Therapeutics joins Cell & Gene: The Podcast's Erin Harris for a discussion on the evolving role computational biology plays in gene therapy development. They also discuss the company's lessons learned from building its own North Carolina-based in-house manufacturing facility as well as Ramaswamy's insight on the future of gene therapy.Subscribe to the podcast!Apple | Spotify | YouTube Visit my website: Cell & Gene Connect...
2023-04-2731 minCell & Gene: The PodcastThe Near-Term Future of Exosome Science with Capricor Therapeutics' Dr. Linda MarbánWe love to hear from our listeners. Send us a message.Dr. Linda Marbán, Ph.D., CEO of Capricor Therapeutics, a clinical-stage biotech focused on the development of cell and exosome-based therapeutics for the treatment and prevention of serious diseases, joins Cell & Gene: The Podcast's Erin Harris to discuss the current state and the near-term future of exosomes. Marbán discusses Capricor’s exosome program and the company’s proprietary allogeneic cardiosphere-derived cells (CDCs) and engineered exosomes. She also covers the company's HOPE clinical trial series' progress to treat Duchenne muscular dystrophy (DMD).Subscribe to the...
2023-04-1328 minCell & Gene: The PodcastInside the World's First-Ever Allogeneic Approval with Atara Biotherapeutics' Pascal TouchonWe love to hear from our listeners. Send us a message.In December 2022, Atara Biotherapeutics’ Ebvallo received European Commission approval as the first-ever therapy for adults and children with EBV+ PTLD. The ground-breaking approval represents the first approval of an allogeneic T-cell immunotherapy ever, globally. Atara Bio's CEO, Pascal Touchon, talks to Cell & Gene: The Podcast's Erin Harris about the biopharma's path to regulatory approval, commercialization plans for Ebvallo, an in-depth look at EBV+ PTLD, the connection between EBV and serious diseases like multiple sclerosis (MS), and much more.Subscribe to the podcast!Ap...
2023-03-3040 minCell & Gene: The PodcastThe Potential of RNA Exon Editing with Ascidian Therapeutics' Romesh Subramanian, Ph.D.We love to hear from our listeners. Send us a message.Cell & Gene: The Podcast Host, Erin Harris, welcomes Romesh Subramanian, Ph.D., CEO of Ascidian Therapeutics, a Boston-based biotech focused on rewriting RNA to the pod. During the episode, Subramanian defines RNA exon editing, and they discuss the differences between RNA exon editing and gene editing. With current programs in ophthalmology, neurological and neuromuscular disorders, as well as rare diseases, Subramanian explains the overwhelming potential of RNA exon editing. Subscribe to the podcast!Apple | Spotify |
2023-03-1620 minCell & Gene: The PodcastAutomating Processes to Scale CGT Manufacturing with PA Consulting's Paolo SicilianoWe love to hear from our listeners. Send us a message.When it comes to manufacturing, many cell and gene therapy companies struggle to automate the diverse processes needed to scale manufacturing. London-based PA Consulting's Associate Partner, Paolo Siciliano, talks to Cell & Gene: The Podcast's Erin Harris about how lean, small biotechs with limited resources and limited funds can strive for automation success. They also discuss what cell and gene therapy companies should do today to address tomorrow’s scalability challenges and what the long-term effects on the business may be from such upfront work.Su...
2023-03-0231 minCell & Gene: The PodcastThe Why Behind In-House Manufacturing With Sangamo's Andy RamelmeierWe love to hear from our listeners. Send us a message.On this episode of Cell & Gene: The Podcast, Host Erin Harris talks to Andy Ramelmeir, EVP Head of Technical Operations at Sangamo Therapeutics, a biotech based in Brisbane, California that applies cell and gene therapy to combat Hemophilia A and other genetic diseases. Ramelmeir explains the why behind the company's decision to build its own Phase 1/2 cGMP AAV in-house facility. He also talks broadly about manufacturing cell and gene therapies and the potential and realistic solutions to needed to drive down manufacturing costs.Subscribe...
2023-02-1621 minCell & Gene: The Podcast2023 Market Outlook with AdBio and ISCT's Miguel ForteWe love to hear from our listeners. Send us a message.Miguel Forte is Entrepreneur in Residence at AdBio, a VC firm based in France, and President Elect of ISCT. Forte and Cell & Gene: The Podcast host, Erin Harris, break down market outlook perspective for the cell and gene therapy space. He provides valuable tips to employ when seeking VC partnership, and he covers ISCT's primary focus areas and what to expect from ISCT 2023 Paris.Subscribe to the podcast!Apple | Spotify | YouTube ...
2023-02-0226 minCell & Gene: The PodcastAn Interview with Dr. Peter MarksWe love to hear from our listeners. Send us a message.Dr. Peter Marks, Director of the Center for Biologics Evaluation and Research (CBER) within the Food and Drug Administration (FDA) sits down with Cell & Gene: The Podcast host Erin Harris to discuss the most anticipated areas of innovation in clinical development, and he offers recommendations to companies in their engagement with the FDA in order to make manufacturing more streamlined and cost effective. Dr. Marks also provides advice to listeners about how and when to engage with CBER, and much more.Subscribe to the...
2023-01-0528 minCell & Gene: The PodcastHospitals And Advanced Therapies with Penn Medicine’s Kevin MahoneyWe love to hear from our listeners. Send us a message.In this episode of Cell & Gene: The Podcast, University of Pennsylvania Health System’s CEO Kevin Mahoney talks to Host Erin Harris about how hospital systems must evolve to meet the needs of cell and gene therapy patients as these complex therapies are commercialized. They discuss what comprises UPHS and the ongoing innovation it brings to advanced therapies as well as how the Health System stays patient-focused at all costs. Subscribe to the podcast!Apple | Spotify |
2021-07-2230 minCell & Gene: The PodcastEnzyvant's Rachelle Jacques on the Biotech’s Lead AssetWe love to hear from our listeners. Send us a message.During this first episode of Cell & Gene: The Podcast, Host Erin Harris talks to Enzyvant’s CEO Rachelle Jacques about the biotech’s lead asset, investigational regenerative therapy RVT-802 for congenital athymia. Jacques provides an update on FDA approval and details what’s next for RVT-802. She explains tissue-based therapies — how far they’ve come and the work that’s left to be done. And, they discuss what being patient-focused means in the world of rare diseases. Subscribe to the podcast!Apple |
2021-07-0824 minCell & Gene: The PodcastIntroducing Cell & Gene: The PodcastWe love to hear from our listeners. Send us a message.Cell & Gene, the online resource that delivers in-depth content from authoritative authors and sources to professionals in the CGT sector, is thrilled to introduce “Cell & Gene: The Podcast.” Cell and gene therapies offer huge potential to treat a wide range of diseases and their possibilities represent a new era in medicine. “Cell & Gene: The Podcast” will explore approved and pipeline therapies, new trends in manufacturing, the long, regulated road to commercialization, and everything in between. In each episode, Cell & Gene Chief Editor, Erin Harris, will talk to an in...
2021-06-3001 min
Living Your GreatnessErin Harris: Yoga Can Change Your Life and Make You HappyErin Harris is an entrepreneur and has been self employed running her own business since 22 years of age. Erin is the studio owner of SoulSpeak Yoga, digital founder of Soul Speak Online and digital media consultant at Erin Harris Media. Erin understands what it takes to turn visions into reality and is excited to bring new ideas to life. In today's episode, Erin talks about her yoga and entrepreneur journey. Erin discusses how yoga has changed her life and added daily happiness. Erin explains how SoulSpeak Yoga has successfully pivoted their business model during a global pandemic. Y...
2021-05-2038 min
Beauty Full Stories with Erin's Faces35. Should We Support Brands That Lack Diverse Representation? Dominique HarrisDominique Harris runs Natty Naturals and Bohemian Collection, handcrafted clean product lines she created with her husband. She is passionate about being a Black woman in the clean beauty space and not only has incredible offerings, but is also doing powerful work to educate her audience about what it means to be Black in America today. Dominique does not shy away from difficult conversations and has made it part of her brand identity. In this episode we talk about how access and exposure contribute to the "whiteness" of clean beauty. Dominique takes us through some of the co...
2021-02-161h 01