Shows
Greedy Gorgon Press Podcast!Episode 5-Unsinkable!The finale! Our "heroes" take on their final challenge. How final is final? Listen in and find out. And then enjoy a break from GGPP for a bit while we plan a heist or two...
2026-02-041h 16
Da Owners BoxMust Be The MoneyThis Episode we discuss DidhedoitAgain?: "Thought I Told You That We Dont Stop", Ryan Garcia, What's Going On w/ Wendy Williams, The Glitch in the Matrix, Lenny Kravitz wants you to put respect on his name, D.A. Fani Willis GGPP, Busta Cancels Tour, South Beach said they closed and more...
2024-03-072h 11
Carlos Ignacio Amantini de Matteis Kawasaki, motos, motociclismo 2023Carlos Amantini Manual de Mantenimiento de Motos 2023 #136Carlos Amantini Manual de Mantenimiento de Motos 2023 #136· 5. 3.-¿COMO CIRCULAR EN MANADA O GRUPO? . Si son muchos y diversos, los que van más lentos delante, marcando el rit siempre son mas lentos los que tienen la moto mas pequeña... ;-) . Dejar un poco de distancia con la moto de delante: lo del rebufo esta bien GGPP de 125....bueno, tampoco hace falta seguir las recomendaciones de la que si no entre el primero y el ultimo puede haber hasta dos cervezas... . No ir detrás del que te prece...
2023-10-2702 min
Authentic BiochemistryImmunoEpigenetics87. Competitive inhibition of HMGCoA-R may enhance apoptosis while blocking cholesterologenesis and GGPP covalent modification of signaling kinases to thwart ETP-All in cell culture.References
JBC.2002. Volume 277, ISSUE 2, P1128-1138.
Cancer Discov. 2022 Mar 1; 12(3): 856–871.
Guerra lectures-lipid metabolic regulation
Guerra lectures-pharmacodynamics and kinetics
2023-06-2829 min
MotoRaceNation - El Podcast de MotoGPPrograma #117: Motogp 2023Programa 117 de nuestro podcast. Habiendo transcurrido 4 GGPP, hacemos un balance de las cuestiones más importantes que han aparecido en el Campeonato
2023-05-0350 min
Diario de MotoGP | Mundo DeportivoGP de Malasia - Diario de MotoGP1. La salida de Bagnaia.
Como él mismo repitió tras la carrera, Pecco hizo la mejor salida de su carrera deportiva. Y lo hizo el día que más necesitaba hacerlo. Salió desde la novena posición de la parrilla y cuando el pelotón llegó al final de recta entró en la curva ¡segundo!
PUBLICIDAD
2. La salida de Quartararo.
¡Chapeau para el Campeón del Mundo francés! Después de firmar la peor posición en entrenamientos de toda la temporada, con caída y micro fractura del dedo medio de la mano...
2022-10-2415 min
R Weekly HighlightsIssue 2022-W36 HighlightsUsing base R to decrypt an Australian coin's hidden messages, the Palmer Penguins data set achieves another milestone, and visualizing multiple statistcal properties with faded raincloud plots.
Episode Links
This week's curator: Miles McBain (@MilesMcBain)
Australian Signals Directorate 50c Coin Decryption
Palmer Archipelago Penguins Data in the palmerpenguins R Package - An Alternative to Anderson’s Irises
Efficient data visualization with faded raincloud plots
Entire issue available at rweekly.org/2022-W36
Supplement Resources
Using distill template with knitr::read_chunk https://twitter.com/apreshill/status/1565752119751237638
Manuscript on raincloud plots: https://wellcomeopenresearch.org/articles/4-63/v2...
2022-09-0829 min
Diario de MotoGP | Mundo DeportivoGP San Marino - Diario de MotoGP1. La consistencia de Bagnaia.
Se acabaron las dudas, Bagnaia pasó en Misano la reválida. Pecco aguantó firme a lo largo de las 27 vueltas de carrera firme las embestidas de Viñales y Bastiani. Sexta victoria de la temporada, la décima en los últimos 10 GGPP. Pecco ya es segundo en el campeonato a 30 puntos de Quartararo con 150 puntos en juego.
2. El curva #4 de Bastianini en la última vuelta.
Según iba llegando a final de carrera todos nos preguntábamos si Enea intentaría pelearle la victoria a Bagnaia. Y vaya que lo intentó...
2022-09-0513 min
Diario de MotoGP | Mundo DeportivoGran Premio de Francia - 'La Bestia' Bastianini no da tregua en Le MansEl Mundial de MotoGP se aprieta. La renta de Quartararo se ve reducida y solo le separan 4 puntos de Aleix Espargaró y 8 del italiano Bastianini.
En este podcast, realizado a pie de pista por Manuel Pecino, repasamos lo más destacado y las claves de este interesante fin de semana de motociclismo. Estas fueron las claves de lo sucedido en la opinión de Manuel Pecino:
1. La vuelta #21.
Fue el momento en el que Bastianini decide deflagrar su ataque sobre Bagnaia. Después de nueve vueltas a rueda le adelanta en cu...
2022-05-1617 min
Diario de MotoGP | Mundo DeportivoGP de las AméricasClaves del GP de las Américas de MotoGP de la mano de Manuel Pecino
1. La salida de Marc.
El problema técnico que dejó clavado a Márquez en la parrilla abortó cualquier opción al podio, que habría sido lo mínimo viendo el ritmo que desplegó es su espectacular remontada. Durante buena parte de la carrera Marc fue el piloto más rápido en pista.
2. El sábado de Rins.
La carrera de Alex quedó condicionada con las dos banderas amarillas del sábado en la Q2...
2022-04-1117 min
Radio Ocotillo por Dennis NoyesAnálisis Gran Premio de Argentina #MotoGPAleix Espargaró logra su primera victoria mundialista y la primera para Aprilia en la clase reina en el GP de Argentina y, en un podio 100% español, completado por Martín y Rins.
El regreso de MotoGP a Argentina será recordado, además, por el retraso con el avión de carga que hizo que la cita de Termas de Río Hondo sólo tuviese dos jornadas, ¡algo inédito!
Dennis y Judit analizan este GP y la situación de todas las marcas a la puerta de próximo gran premio en Austin y, a la esper...
2022-04-051h 06
Voice to CultureCollege Apps and Friendsgiving ft. GGPP Studios | Bonus Episode✨Hey everyone✨
On this episode, we chatted with GGPP Studios, a youth established podcast!! We discussed the struggles of distance learning, what we should've known as freshmen in high school, the advantages and disadvantages of taking AP classes, and what we're thankful for!! Show GGPP some love down in the comments👇 and check out their debut album OK 😎🤘🏼 (we heard it's pretty fire)
GGPP
🌻 youtube: GGPP Studios
🌻 instagram: @ggppstudios
🌻 debut album OK: https://www.youtube.com/watch?v=FMQlo2hsaCQ
🌻 spotify: GGPP
Tea...
2020-12-0948 min
iBiology Videos Without SubtitlesRussell DeBose-Boyd Part 2: Schnyder Corneal Dystrophy: Importance of UBIAD1 in Regulation of CholesterolIn Part 2 of his talk, DeBose-Boyd introduces a rare genetic disorder known as Schnyder Corneal Dystrophy (SCD). SCD is characterized by accumulation of cholesterol in the corneas of affected individuals, indicating that the genetic defect in SCD may affect cholesterol synthesis. Mutations in the UBIAD1 gene cause SCD – therefore, DeBose-Boyd’s lab sought to understand the role of UBIAD1 in regulation of cholesterol metabolism. They found that UBIAD1 acts as a sensor for levels of the metabolite GGpp, which enhances sterol-mediated ERAD of HMG CoA reductase. In the presence of GGpp, UBIAD1 releases HMG CoA reductase, leading to its proteasomal degr...
2020-10-2916 min
GGPP PodcastS2E5: Travis Thai — Student @ UC Davis | Interview #4Wow. I guess we upload once a month now. But don't worry, there's other content coming out this month aside from just podcasts. For now, you can enjoy this interview from like 7 months ago at Disneyland. It's with a college student. Also he goes to UC Davis. Also he's my brother. Pretty interesting stuff 👍
• Recorded on Sunday 12/29/19 & Monday 12/30/19
• Timestamps
— Summary + Ad at 00:00
— Airport at 02:02
— Short Microphone Story at 04:29
— Actual Interview at 05:16
— Outro at 35:22
• Apply to be an Honorary Eagle if you go to Independence! ht...
2020-08-0335 min
GGPP PodcastS2E4: mar¢el & becca c. — Musicians & Singers | Interview #3Last week, we had the chance to interview musicians Ellis Marcel & Rebecca S. Almogela Cabagbag, who go by their artist names as mar¢el (or marcel valentine) & becca c., respectively. They recently collaborated to release a new single titled "i'll be the scott to your ramona," featuring vocals from both and production from mar¢el. Unfortunately, Rebecca was unable to join us for an in-person interview, but we do have some words from her!
In this episode, we learn about the two upcoming high school seniors and their musical upcomings, from childhood inspirations to th...
2020-07-0950 min
GGPP PodcastS2E3: ninjandru — Musician, Photographer, & Artist | Interview #2We had a chat with Andrew Nguyen, who goes by the artist name ninjandru. A soon-to-be senior at Piedmont Hills High School, Andrew is an active photographer and musician. His debut single "same," which is also his most successful song to date, exists as a collaboration with fellow artist vivithot (Viviane Nguyen) that has garnered over 100,000 plays on Spotify.
In this episode, ninjandru begins by introducing himself and his musical beginnings, talking about the various instruments he learned to play and previously making lo-fi hip hop. Then, he describes his musical process and shares the stories behind...
2020-06-1128 min
GGPP PodcastS2E2: Profound Discussion on Simping | Interview #1Have you ever wondered what simping is? Are you worried that you might be a simp? Do you wish to hear some opinions about simping shared from current teenagers? Look no further.
• This was recorded through a coordinated effort on our official Discord server! Check it out at https://discord.gg/v6nPryF
| This episode was also shortened into a succinct 5 minute podcast, which you can find here: https://soundcloud.com/ihsunicef/contemporary-simping
| Keep updated with all our activities: https://campsite.bio/ggppstudios
• Date Recorded: Saturday 05/16/20
| Timestamps & Participants
2020-05-1958 min
GGPP PodcastS2E1: Aki Kumar Live at IHS | Bonus #1• What is this? It is a recording of the San Jose based "Bollywood Blues" musician, Aki Kumar, performing live at Independence High School in C-Commons on Thursday, February 13, 2020.
• Why does it start in the middle of the performance? Because I started recording too late. Sorry.
• Why does it sound like it is distorting sometimes? Because I left the microphone volume too high. Oops.
• Why is a bonus like 40 minutes long? Because this is not really a typical GGPP episode where we do fun random things. Those episodes would be Adventure episodes, and they will com...
2020-05-0143 min
GGPP PodcastSEASON 2: TRAILERHello. GGPP is back. Please check out and enjoy the two videos below that we have edited for your entertainment.
| Video #1: GGPP @ Light the Night: https://youtu.be/uj_pMYbez-A
| Video #2: Multi-Cultural Rally Recap 2020: https://youtu.be/wozg5Q_7fww
| Here is a link to the cover at the end (GTFA). It is also free download so have fun with that: https://soundcloud.com/ihsunicef/gtfa-ggpp-cover
| All our links can be found here: https://campsite.bio/ggppstudios (includes Youtube, Instagram, Spotify, Interview Request, etc.)
| Date Recorded: Thursday 06/18/20 (Originally published...
2020-04-1007 min
GGPP PodcastS1E19: End of the Decade Remarks | Bonus #7This will be the last podcast episode of the decade, so we gotta end it off with what is arguably our worst recording yet. Cheers!
• DATE RECORDED: Wednesday 12/11/19 (After Unisocial ended)
• TIMESTAMPS:
0:00 - start
| 0:14 - this is the end of the decade podcast
| 0:32 - things that happened (& didn't) this decade
| 1:16 - what is ggpp?
| 1:56 - thank you
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2019-12-3102 min
GGPP PodcastS1E18: Twice Club & LOT Grams | Adventure #9hey! hope you guys are enjoying the vacation break! please enjoy this episode of the podcast where we follow twice club around for a while and then make and deliver lights on trafficking club grams! it's pretty cool ngl :) // DATE RECORDED: monday 12/16/19 // TIMESTAMPS (very useful): 00:00 - intro | 01:22 - leaving french | 01:46 - twice club spotted! | 02:26 - entering classroom #1 | 03:11 - PERFORMANCE #1: "fancy" (featuring otamatone played by alex le) | 04:24 - interlude between performances | 05:35 - alex explains what we are doing & how twice grams work | 06:10 - entering classroom #2 | 07:21 - PERFORMANCE #2: "fancy x feel special" | 09:09 - interlude/end of performance | 10:13...
2019-12-2952 min
GGPP PodcastS1E17: Beats, Band Room, & AP Biology Project | Adventure #8this was recorded a few months ago, but that doesn't mean it can't be released now! please enjoy listening to us going around school and doing random things on a nice friday afternoon. yeah!
DATE RECORDED: friday 10/25/19
TIMESTAMPS (there's so many i stg):
0:00:00 - sponsor: anchor podcasts (we'll donate ad money to unicef don't worry lol)
0:01:23 - start // danny matlob finding out that he was in the interview
0:02:56 - ryan la's viet test
0:03:17 - friendly reminder to podcast watchers
0:04:23 - going to cloud 9
0:04:45 - sahib dokal rapping over "actual fire"
0:06:24 - beat making on the spot
0:06:44 - going to band...
2019-12-281h 13
GGPP PodcastS1E16: Robotics, Uber, & Target Shopping | Adventure #7wow this was recorded a very long time ago. ok that's all go listen to find out what this fun episode is about :)
DATE RECORDED: thursday 10/24/19
TIMESTAMPS:
00:00 - sponsor: anchor podcasts (we'll donate ad money to unicef don't worry lol)
01:23 - intro
01:56 - start of episode
02:26 - robotics (deciding who will be added to the team & getting uber discounts)
17:07 - walking to the library for uber
20:36 - library pit stop
22:56 - vivian hong joins the pilgrimage
23:32 - uber #1 is here (it was completely silent bruh)
24:01 - we are at target
27:32 - choosing the cardstock
29:16 - sweedish fish purchase
30:29 - chips...
2019-12-2757 min
GGPP PodcastS1E15: GGPP @ the Key Club Benefit Show | Special Event #1Join us on this special, wild ride highlighting the struggle of GGPP in coming up with an act for the Key Club Benefit Show, including interviews with upper-class insight and insider info on clubs, college, and just random stuff. I recommend that you just leave this in the background while doing something so you don't miss on any good parts if you skip around, but again no one has time for that so some timestamps are below! Also, check out the video for this episode! Please! Thank you! Merry Christmas! Happy Hanukkah! Joyous Kwanzaa! also sorry for the trash...
2019-12-261h 34
GGPP PodcastS1E14: Mih-News (US History Project) | Bonus #6lol forgot to post this when it was made for a us history project a month and a half ago. still really good tho ngl.
link to the full video: https://youtu.be/uYktMP6Do3w
date recorded: november 4, 2019
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2019-12-2305 min
GGPP PodcastS1E13: AP Chemistry Semester 1 Review | Adventure #6audio recording of the three day review for ap chem in hafalia's class. this covers chapter 1-4, 10-13, and 6-9 notes, and it was recorded during periods 2/3. thank you. TIMESTAMPS: 0:00 - start of day 1 (intro/class schedule for the rest of the week and finals) 5:06 - chapter 1: introduction: matter and measurement 16:24 - chapter 2: atoms, molecules, and ions 22:18 - break (includes hafalia's recording of the winter concert from 12/10/19; in stereo) 30:15 - announcements (if you can hear them) 36:12 - chapter 3: chemical reactions and reaction stoichiometry 42:13 - chapter 4: reactions in aqueous solution 47:36 - end of day 1 48:06 - start of day 2 (class finals...
2019-12-131h 57
GGPP PodcastS1E12: Post-PSAT Interviews | Bonus #5now that the PSAT results have been officially released, i can post this legally. i think.
date recorded: wednesday 10/16/19
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2019-12-1010 min
GGPP PodcastS1E11: Run, Hide, Defend Drill | Bonus #4happy thanksgiving if you are reading this on thanksgiving, but like why are you listening to this on thanksgiving like bro spend family time and enjoy thanksgiving fr...
btw we get broken into at 2:18
date recorded: wednesday 10/23/19 (in hafalia's class if you were concerned)
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2019-11-2810 min
GGPP PodcastS1E10: Robotics After School | Interview #2INTERVIEW #2 IS OUT! This took longer than expected due to schoolwork and me just being lazy and not editing, but it's out now! As always, we hope you guys enjoy!
• Date Recorded: Thursday 10/17/19
| Timestamps
– Intro at 00:00
– Robotics at 01:30
– Reactions to the Podcast at 01:57
– Benjamin Le Interview at 03:03
– Ryan La's Spreadsheet at 08:01
– Benjamin Le Interview (cont.) at 08:16
– Tryouts Area/Hardware Team Members at 11:37
– Robotics Tryouts Interviews at 12:57
– Mihir Baviskar Interview at 15:19
– Vince Malaca Interview at 18:31
– Alex Le Leaves &am...
2019-11-2440 min
GGPP PodcastS1E9: Test Corrections in Hafalia | Adventure #5*NOTE: This episode contains explicit content, so look through the timestamps to find when there is no explicit stuff if you don't want to hear the bad stuff. Yeah.*
pretty fun and interesting episode considering most of it is actually interviews but the overall recording is like an episode. will certainly consider doing more of these in the future!
DATE RECORDED: Wednesday 11/20/19
TIMESTAMPS:
00:00 - start
00:12 - live beat demo with alex le
00:54 - [very explicit] brian le (lil monk) freestyle rap
04:16 - [explicit] rhetorical analysis/explication of brian's rap
05:42 - "my day" freestyle
06:24 - interview discussion
07:10 - brian's opinion on...
2019-11-2140 min
GGPP PodcastS1E8: Mindfulness | Bonus #3Yes, this is over a month old but I need something to put out there while I get back into the podcast flow lol
• Date Recorded: Monday 10/14/19
• Location: Mrs. Meniado's 1st Period AP Calculus AB Class
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2019-11-1806 min
GGPP PodcastS1E7: Behind the Scenes: UNICEF General Meeting Week 7 | Adventure #4enjoy this special edition of the week 7 general meeting recorded from the back of the class. also includes beat making, selling of grams, short interviews, and apush class
date recorded: friday 10/25/19
timestamps:
00:00 - sponsor: anchor podcasts (we'll donate ad money to unicef don't worry lol)
01:25 - intro
01:48 - before the meeting (beat making, selling grams, etc.)
06:43 - start of general meeting
07:03 - potw (picture of the week)
07:25 - potw discussion
08:18 - potw explanation
09:24 - book drive (led by phung n), vinci park fall festival (led by chelsea & dylan), light the night (led by imarie)
09:43 - short interviews
11:09 - UBA meeting...
2019-10-2732 min
GGPP PodcastS1E6: Mr. Nguyen's After-School Interview | Bonus #2cool little interview we did with science teacher mr. nguyen because we saw him walking somewhere. very uplifting!
date recorded: thursday 10/17/19
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2019-10-2704 min
GGPP PodcastS1E5: Danny Matlob w/the Weight Room Fellas | Interview #1IT'S FINALLY OUT! This is the first official interview of the GGPP podcast. It's actually edited and includes a proper intro with music as well as a proper outro. Various topics in the interview include: bathroom interview, weight lifting and exercise tips, short interviews with various people in the weight room, philosophical questions, talking about the podcast and the form, asmr with machines, stoplights, rhetorical analysis & soapstone, food, pomegranates, clothing, etc. HOPE YOU GUYS ENJOY!
• Date Recorded: Wednesday 10/16/19
| Credits: Ethan Thai [HOST]
Instagram: @thefieryhaze
Facebook: Ethan Thai
| Da...
2019-10-2443 min
GGPP PodcastS1E4: Mrs. Meniado's One Question Interview | Bonus #1A one question interview during 6th period of Mrs. Meniado's AP Calculus AB class. Splendid!
• Date Recorded: Friday 10/18/19
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2019-10-2100 min
GGPP PodcastS1E3: UNICEF General Meeting Week 6 | Adventure #3Back at it again with the week 6 general meeting if you missed it.
• Date Recorded: Friday 10/18/19
| Timestamps
– Sponsor: Anchor Podcasts (we'll donate ad money to UNICEF) at 00:00
– Start of Meeting at 01:33
– POTW (photo of the week) at 01:56
– POTW Explanation at 03:38
– Book Drive [event] at 04:25
– Vinci Park Fall Festival [event] at 05:27
– Light the Night [event] at 06:30
– Recycling [every week] at 07:08
– UNICEF Bay Area Meeting [event] at 07:33
– Tailgate Recap at 08:01
– Weekly Activity: Children's Rights (led by Sydney, Brittney, and...
2019-10-1918 min
GGPP PodcastS1E2: Tailgate Afterschool | Adventure #2An unedited recording of the tailgate afterschool at IHS and part of computer science club. This episode has a few interviews as well, but I apologize to those who I told that I would edit out the bad parts during the interviews because I didn't lol. Also it has some bad words so don't listen with your parents
• Date Recorded: Friday 10/11/19
• Btw, if this is your first time visiting the podcast, I'd recommend you start with S1E5 and go up from there since the first 4 episodes aren't edited. Thank you very much for listening!
...
2019-10-131h 01
GGPP PodcastS1E1: UNICEF General Meeting Week 5 | Adventure #1A mostly unedited recording of the IHS UNICEF general meeting for week 5 if you missed it.
• Date Recorded: Friday 10/11/19
| Timestamps
– Sponsor: Anchor Podcasts (we'll donate ad money to UNICEF) at 00:00
– Start at 02:42
– Weekly Activity at 10:32
– Unofficial End at 17:53
• Btw, if this is your first time visiting the podcast, I'd recommend you start with S1E5 and go up from there since the first 4 episodes aren't edited. Thank you very much for listening!
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This episode is sponsored by
· Anchor: The easiest way to make a podcast. h...
2019-10-1323 min
GGPP PodcastS1E0: French w/Biaye, Lunch, & History w/Barcelona | Adventure #0How is there an episode #0? Well, this episode includes recordings we did on the first day the mic recorder was brought to school, but there's mostly random stuff. Not to mention, it's 2 hours long unedited (which also means we can't post it to SoundCloud for free). I would personally say that the only part worth listening to is the segment during french class when this podcast was named, but we'll let you find out when that is.
• Date Recorded: Thursday 10/10/19
| Timestamps
– Sponsor: Anchor Podcasts (we'll donate ad money to UNICEF) at 0:00:00
– French...
2019-10-132h 09
Mapping 8Mapping 8, 1x12+1. Gran Premio de Tailandia.Llegamos al episodio 12+1 del programa, el correspondiente al Gran Premio de Tailandia de MotoGP, que ha dejado como principal noticia la proclamación de Marc Márquez como 8 veces campeón del mundo de motociclismo, en su primer 'match ball' y a 4 GGPP del final de la temporada. Además, repasamos los problemas de Jorge Lorenzo y Valentino Rossi en comparación a sus equipos y marcas, la situación en Moto 2 tras la victoria de Marini y la nueva acción polémica de Darryn Binder en Moto 3, en la que se vio envuelto Arón Canet, lo que acerc...
2019-10-121h 33
Mapping 8Mapping 8, 1x12+1. Gran Premio de Tailandia.Llegamos al episodio 12+1 del programa, el correspondiente al Gran Premio de Tailandia de MotoGP, que ha dejado como principal noticia la proclamación de Marc Márquez como 8 veces campeón del mundo de motociclismo, en su primer 'match ball' y a 4 GGPP del final de la temporada. Además, repasamos los problemas de Jorge Lorenzo y Valentino Rossi en comparación a sus equipos y marcas, la situación en Moto 2 tras la victoria de Marini y la nueva acción polémica de Darryn Binder en Moto 3, en la que se vio envuelto Arón Canet, lo que acerca al...
2019-10-121h 33
The Sartorial Geek PodcastGeek Girl Pen Pals with Joanna and SummerBefore we get started, don’t forget about our Patreon exclusive! We have a limited edition Hamilton-inspired pin that is only available until March 31 only to people who become Patrons during this month! Our sponsor for this week’s episode is Audible. Audible is perfect for people like me who want to read a lot of stories but know they don’t have time to actually read them. Check it out for free for 30 days at audibletrial.com/sartorialgeek. This week we’re chatting with two leaders of one of my favorite g...
2019-03-1535 min
Podcast El sitio de mi recreo 2.0Planeta Motos Cap. 4 (06-04-16)Manu guiao, Nacho González y Sara Montoro analizan la actulidad de los mundiales de Motogp y SBK en los ggpp de Argentina y Aragón respectivamente
2016-04-081h 00
Medizinische Fakultät - Digitale Hochschulschriften der LMU - Teil 06/19Modulation des HMG-CoA-Reduktase/GGPP/ Rho-Signalwegs zur Apoptoseinduktion in adhärenten MyelomzellenDas multiple Myelom ist eine Erkrankung, bei der terminal differenzierte Plasmazellen das Knochenmark infiltrieren, wodurch das typische klinische Bild eines Myelompatienten zustande kommt. In den letzten Jahren haben sich die Hinweise gehäuft, dass die Bindung der Myelomzellen im Knochenmark an Stromazellen die Chemosensitivität der Myelomzellen vermindert und somit zur „de-novo drug resistance" beiträgt.
Das primäre Ziel dieser Arbeit war es, ein Zellmodell zu entwerfen, mit welchem die Untersuchung der Interaktionen von Stromazelle und Myelomzelle und damit der zelladhäsionsabhängigen Zytostatikaresistenz (CAM-DR) möglich ist. Darüber hinaus sollte diese Zytostatikaresistenz charakterisiert und mögliche molekulare Therapietar...
2006-11-1600 min
Biologie - Open Access LMU - Teil 01/02Inhibition of geranylgeranyl diphosphate synthesis in in vitro systemsThe incorporation of [14C]mevalonate and [14C]isopentenyl diphosphate into geranylgeranyl diphosphate was investigated in in vitro systems from Cucurbita pepo (pumpkin) endosperm and from Avena sativa etioplasts. Mevalonate incorporation was effectively inhibited in the pumpkin system by geranylgeranyl diphosphate and geranylgeranyl monophosphate but less effectively by phytyl diphosphate or inorganic diphosphate. Membrane lipids, geranyllinalool, or lecithin enhanced mevalonate incorporation in the Cucurbita system. Incorporation of isopentenyl diphosphate was also enhanced by lecithin and inhibited by geranylgeranyl diphosphate in the Cucurbita system. No lipid enhancement was found in the Avena system; inhibition by GGPP required a much higher GGPP concentration...
1985-01-0100 min