Shows
Dr RR Baliga's "Got Knowledge Doc" PodkastFrom MRAs to ASIs: Rewriting Heart Failure’s Aldosterone Story🎙️ From MRAs to ASIs: Rewriting Heart Failure’s Aldosterone Story 🚨 New Episode Alert! 🎧 Title: From MRAs to ASIs: Rewriting Heart Failure’s Aldosterone Story 💔🧬💊  In this episode of Got Knowledge Doc, we unpack the double-edged role of aldosterone in heart failure and kidney disease—from its genomic mischief to its nongenomic chaos via GPER. We dive into: ✅ Why MRAs aren’t enough 🔬 What ASIs bring to the table 📉 How new trials like FIDELIO, FIGARO, and PREVENT-HF are shaping the future If you treat heart failure, study...
2025-08-0208 min
Eczema BreakthroughsStaph’s secret superpower and their accomplice StreptococcusTwo new studies from the Society for Investigative Dermatology (SID) conference reveal how Staph bacteria use clever strategies to disarm the skin's barrier maintenance function and work with other bacteria to amplify inflammation. Join us for an interview with Dr. Nathan Archer and Dr. Laine Feller from John Hopkins School of Medicine who explain how Staph aureus bacteria uses its superantigen superpower to hinder lipid production ... and more new research from this year's SID meeting.
2025-05-2213 min
PeDRA PearlsPeDRA Weekly Update - May 6, 2025PeDRA Annual Conference - Registration is open!PeDRA at SID!Getting to Know You: Eunice BolayMolluscum MinutePub Club Episode 15GPER Childhood Eczema Prevention Research GrantPediatric Hidradenitis Suppurativa Challenge GrantPeDRA Emerging Investigator Research GrantPeDRA Awards ProgramSociety for Pediatric Dermatology Annual Meeting10th Annual Symposium on Hidradenitis Suppurativa Advances
2025-05-0604 minEczema BreakthroughsNew nonsteroidal eczema cream approved for kidsNew treatment alert! The FDA recently approved Tapinarof, applied as a cream, for kids 2 years and up. We ask Dr. Leon Kircik from Icahn School of Medicine, NY, who led the clinical trials about the safety, efficacy and side effects of Tapinarof. And because we are parents too, we ask: How quickly does it work? Can you start/stop it as needed? How easy will it be to access? And more. If you like our podcast, please consider supporting it with a tax deductible donation. Research discussedTapinarof Improved Outcomes and Sleep for Patients and Fam...
2025-04-3022 min
PeDRA PearlsPeDRA Monday Update - April 21, 2025Pediatric Hidradenitis Suppurativa Challenge GrantPeDRA at SIDSPD Mentorship Awards and Esterly Visiting LectureshipGPER Childhood Eczema Prevention Research GrantNFED Research GrantsPeDRA Awards ProgramPeDRA Annual Conference
2025-04-2102 minEczema BreakthroughsHot off the press - What researchers are talking about at AAAAI Allergy Conference.What to look out for in eczema moisturizers, why eczema babies have rosy red cheeks and can allergies transfer to baby from breast milk? Join Korey Capozza, Dr. Jessica Hui-Beckman (National Jewish Health) and Dr. Kirsi Jarvinen-Seppo (University of Rochester) to find the answers. If you like our podcast, please consider supporting it with a tax deductible donation. Research discussedConsumer Preferences, Product Characteristics, and Potentially Allergenic Ingredients in Best-selling MoisturizersEarly Life Cheek Skin Barrier Changes are Associated with Atopic Dermatitis DevelopmentPrevention of IgE-Mediated Food Allergy: Emerging Strategies Through...
2025-03-2016 minEczema BreakthroughsCould biologic injectables change the eczema trajectory?Could injectable drugs called "biologics" stop eczema by teaching a child's developing immune system to be less reactive? Dr. Amy Paller from Northwestern University Chicago and Dr. Elaine Siegfried from Saint Louis University in Missouri discuss stopping or tapering biologics and what happens to the immune system when we are on them. If you like our podcast, please consider supporting it with a tax deductible donation. Research discussedClinical remission and therapy-free remission in pediatric patients with moderate-to-severe atopic dermatitis treated with dupilumabFactors Associated with Remission of Eczema in ChildrenP...
2025-02-1921 minEczema BreakthroughsYou are what you eat or, more precisely, what your MICROBIOME eats.How much influence does the gut microbiome have on developing eczema or allergies? Turns out, quite a lot. Join this special excerpt from our research symposium to learn how antibiotics in pregnancy and early childhood increases eczema risk and how adding "biotics" might prevent it in the first place. Our speakers are Dr. David Margolis (University of Pennsylvania) and Dr. Nikole Kimes (Siolta Therapeutics). If you like our podcast, please consider supporting it with a tax deductible donation.
2024-11-1321 minEczema BreakthroughsCan Traditional Chinese Medicine treat eczema?Traditional Chinese Medicine (TCM) uses biological extracts to treat disease. Eczema sufferers may take a herbal bath, apply a specially formulated cream or drink herbal tea as part of TCM treatment. Dr. Xiu Min Li from New York Medical College explains TCM and we ask: Is Traditional Chinese Medicine (TCM) safe for newborns? Can you use TCM and topical steroids simultaneously? Could TCM prevent the allergic march? Research mentionedInvestigation of Berberine's Potential in Attenuating Staphylococcus aureus-Induced Inflammatory ResponsesInvestigation of In vitro Anti-inflammatory and Antimicrobial Effects of BerberineEffect of Trad...
2024-10-2221 minEczema BreakthroughsHow to get smiles while applying moisturizer, sleep strategies and other eczema care adviceAre you feeling lost and don’t know where to find trusted advice on managing eczema? Introducing ECZHALE, your one-stop-shop for reliable information and resources on eczema care. Join Dr. Jennifer LeBovidge, psychologist and Assistant Professor at the Atopic Dermatitis Center at Boston Children’s Hospital, and GPER’s Christine Pham Cutaran as they discuss the challenges of being an eczema caregiver and where you can turn for help. Literature mentionedMultidisciplinary interventions in the management of atopic dermatitisAtopic dermatitis: therapeutic care delivery: therapeutic education, shared decision-making, and access to careImprovi...
2024-09-1425 minEczema BreakthroughsCould we take a pill to eradicate Staph aureus on the skin?Is getting rid of Staph aureus in the gut the key to improving eczema? And can we control it without antibiotics? Join us as we ask these questions and more of Dr. Michael Otto, Chief of the Pathogen Molecular Genetics Section at the National Institute of Allergies and Infectious Diseases. (And if you like our podcast, consider supporting it with a tax deductible donation). Research mentionedProbiotic for pathogen-specific Staphylococcus aureus decolonisation in Thailand: a phase 2, double-blind, randomised, placebo-controlled trialCommensal Staphylococcus epidermidis contributes to skin barrier homeostasis by generating protective ceramides Th...
2024-07-2419 minEczema BreakthroughsWho gets eczema and who grows out of it - and why? Are detergents, antibiotics and tiny plastics to blame?Korey Capozza travels to Spain for the European Academy of Allergy and Clinical Immunology Congress where she speaks to researchers that are trying to explain the allergy epidemic and what we can do about it. Highlights: Dr. Magdalena Zemelka-Wiacek (Poland) explains microplastics cause inflammation. Tami Landau (Israel) uses “big data” to determine which children will develop eczema, and Dr Thomas Bieber (Germany) accesses the German Biobank to understand why some children go into remission.   Research MentionedMechanisms of gut epithelial barrier impairment caused by food emulsifiers polysorbate 20 and polysorbate 80 Follow-up to adolescence after early pean...
2024-06-2717 minEczema BreakthroughsPregnancy and the allergic trajectoryCould the diet and lifestyle of a mother during pregnancy influence whether her baby will develop eczema? Our podcast guests are studying the role that diet and the gut microbiome play in pregnancy. Join Dr. Carina Venter and Dr. Susan Lynch as we discuss what pregnant mothers can do to reduce the chances of baby developing eczema or allergies. (And if you like our podcast, consider supporting it with a tax deductible donation).Research mentionedDelayed gut microbiota development in high-risk for asthma infants is temporarily modifiable by Lactobacillus supplementationHeritable vaginal bacteria inf...
2024-05-2920 minEczema BreakthroughsNew Eczema Guidelines from the Allergy Societies: Takeaways and SurprisesFrustrated by eczema care that ignores patient priorities? New guidelines from the medical societies for allergists and immunologists may help change that. These guidelines were informed by the views of eczema patients and caregivers and based in evidence (hallelujah!). We chat with the guideline co-authors Dr. Lynda Schneider, founder and director of the Atopic Dermatitis Center at Boston Children’s Hospital, and Dr. Derek Chu, director of the challenge clinic for allergy diagnosis, research and treatment at McMaster University, about some of the new and surprising ideas they recommend. (And if you like our podcast, consider supporting it with a t...
2024-05-2919 minEczema BreakthroughsNew Eczema Guidelines from the Allergy Societies: Takeaways and SurprisesFrustrated by eczema care that ignores patient priorities? New guidelines from the medical societies for allergists and immunologists may help change that. These guidelines were informed by the views of eczema patients and caregivers and based on evidence (hallelujah!). We chat with the guideline co-authors Dr. Lynda Schneider, founder and director of the Atopic Dermatitis Center at Boston Children’s Hospital, and Dr. Derek Chu, director of the challenge clinic for allergy diagnosis, research and treatment at McMaster University, about some of the new and surprising ideas they recommend.  Research mentionedAtopic dermatitis guidelines: 2023 Is Foo...
2024-04-3018 minEczema BreakthroughsResearch Highlights from the American Academy of Dermatology Meeting 2024Five GPER staff members attended the American Academy of Dermatology conference in February, the biggest gathering of dermatologists worldwide. We bring you the newest treatments and latest research straight from the source. Join our conversation with GPER staffers Korey Capozza, Kara Orevillo, Christine Cutaran and Michelle Tu about what stood out this year. (And if you like our podcast, consider supporting it with a tax deductible donation).
2024-03-2114 minEczema BreakthroughsIs the gut microbiome the key to allergic disease?Could we cure allergies by taking probiotics or transplanting the gut microbiome from a healthy person? What does all this mean for eczema/allergy prevention? To find out, join our conversation with Dr. Rima Rachid, allergist and immunologist at Harvard Children’s Hospital, and Meenal Lele, eczema mom and author of Baby and the Biome. We discuss the promising trials with fecal microbiota transplants for food allergic children as well as the best probiotic to take for eczema and when it’s important to take it. (And if you like our podcast, consider supporting it with a tax deductible donation...
2024-02-1318 minEczema BreakthroughsBrilliant new ideas for beating eczema from eczema parentsThe winners of the 2023 Big Ideas for Eczema contest share their novel ideas and how they came up with them. Our citizen scientist winners are Elizabeth Shores, Hannah Mitchell and Armando de la Libertad. Would you try these ideas?  (If you like our podcast consider supporting it with a tax deductible donation.) If you have an idea of your own, find out more about the Big Ideas 2024 competition here.Â
2024-01-1720 minEczema BreakthroughsEczema Research Highlights of 2023What are the top research discoveries of 2023 related to eczema? Tune in to learn about new, needle-free Epi-Pen alternatives, painless tests for detecting eczema before it appears, and insights about how to address anxiety and depression related to eczema. Guests include Albert Chong of University of Southern California, Dr. Ruchi Gupta of Northwestern University, Dr. Ian Myles of NIH, and Dr. Kiwako Yamamoto-Hanada of National Children's Hospital, Tokyo. P.S. If you like our podcast, consider making a donation to GPER!Research discussed in this podcastmRNAs in skin surface lipids unveiled atopic dermatitis at 1 month...
2023-12-1922 minEczema BreakthroughsWhat’s hot in eczema prevention?Can moisturizers help prevent eczema? If so: when, what and how should they be applied? Can probiotics help? If so: who should take them - mother or baby? These questions and more are answered by Helen Brough, pediatric allergist and head of service at Evelina London Children's Hospital (UK). As part of our recent research symposium, she explains what research is going on in eczema management and prevention and what is still needed to make prevention a reality. She also has important tips for eczema care now. (If you like our podcast consider supporting it with a tax deductible d...
2023-11-3014 minEczema BreakthroughsThe inflammation-microbiome connection and how new therapies can correct bothNew biological therapies like dupilumab target Type 2 inflammation, but new research shows they are also modifying the skin microbiome. In this episode we discuss what Type 2 inflammation is, why it matter in eczema, and how it modifies the microbiome. Our guest is Dr. Lisa Beck (Co-Director of the Center for Allergic Disease Research, University of Rochester Medical Center, NY) who has dedicated her 35 year career to understanding why some eczema patients are susceptible to skin infections and finding safe and effective eczema treatments.Research associated with this podcastType 2 Inflammation Contributes to Skin Barrier Dysfunction in...
2023-08-2421 minEczema BreakthroughsIs Dupixent forever? Is tapering Dupixent desirable or even possible?Dupixent has transformed the lives of people with moderate to severe eczema, but will patients need to use it indefinitely? In this episode we explore tapering Dupixent (also known as dupilumab) with two researchers from University Medical Center Utrecht in the Netherlands that have created a patient-led roadmap for successful tapering. They are: Pediatric Dermatologist Dr. Marlies de Graaf, Head of the National Expertise Center of Atopic Dermatitis in Children; and Dr. Celeste Boesjes, who is a PhD candidate and Medical Doctor.Research Discussed in this PodcastSuccessful tapering of dupilumab in atopic dermatitis patients with...
2023-07-2722 minEczema BreakthroughsDitching itch: What we know and what we still have to learnItch. It’s the hallmark symptom of eczema and the most troublesome. In this podcast we discuss why the eczema itch is so hard to treat and explore effective treatment options. We have the privilege of speaking with Dr. Shawn Kwatra, international leader in chronic itch research and Director of John Hopkins Itch Centre in Baltimore, and Dr. Shivani Patel, a practicing pediatric dermatologist who specializes in treating children with eczema. (If you like our podcast consider supporting it with a tax deductible donation.)Research discussed in this podcastMolecular and cellular mechanisms of itch and p...
2023-06-2922 minEczema BreakthroughsExposures to chemicals in our environment and the allergy / eczema epidemicWhat do microplastics, dishwasher rinse-aid, air pollution and processed foods have to do with eczema? Join us as we explore why allergic diseases were rare for our grandparents but now affect two billion people worldwide.  Explaining the link is our guest, Professor Cezmi Akdis. He is a global leader in immunology, specializing in allergic diseases, editor-in-chief of Allergy, and a Professor at the University of Zurich in Switzerland.  (If you like our podcast consider supporting it with a tax deductible donation.)Research discussed in this podcast:Scrubbing away our collective healthDoes the epi...
2023-04-2026 minEczema BreakthroughsWas it something I did? Does the eczema trajectory begin even before a baby is born?Have you ever wondered if there is anything you can do during pregnancy to lower the chance of your baby developing eczema? Join our discussion with Dr. Suzanne Barshow from Stanford University who is overseeing the SUNBEAM study which investigates which factors lead to the development of allergic diseases, and Kortney Kwong Hing, co-host of The Itch Podcast and eczema sufferer who would like to avoid passing on her allergies to her future children. (If you like our podcast consider supporting it with a tax deductible donation.)
2023-03-2719 minEczema BreakthroughsMeet the "citizen scientist" winners of our Big Ideas for Eczema ChallengeIn our very first “Big Ideas” competition, we asked those who live with eczema for big ideas that could lead to better treatments or a cure. Learn about three brilliant ideas from the winners to help kids with eczema in the future. Our guests are Armando de la Libertad, Nic Novac and Angela Tiru, parents and patients who used their experiences and insights to come up with innovative research ideas. (If you like our podcast consider supporting it with a tax deductible donation.)Have a Big Idea of your own? Enter this year’s Big Ideas competition here.
2023-02-0924 minEczema BreakthroughsEmbracing your allergies: How micro-exposures to an allergen can make eczema better.Could allergy drops (or shots) be the answer to reducing eczema flares? Recent research suggests that immunotherapy can improve eczema symptoms, and it is safe for kids, easy to use and inexpensive. We discuss how the treatment works and it’s potential to improve lives, especially for kids who can’t access expensive treatment programs. Our guests are Dr. Derek Chu, professor of medicine at McMaster University in Canada, and Dr. Sarah Langer, a pediatric immunologist from the University of Sao Paulo, Brazil. (P.S. If you like our podcast consider supporting it with a tax deductible donation).Re...
2023-01-2620 min
Eczema BreakthroughsIs eczema inevitable for some kids? Breakthrough research from 2022 suggests that testing and intervention for newborns could change the trajectory.Imagine if doctors could use a non-invasive test on newborns to predict their risk of developing eczema?  Now it might be possible. What’s more, new research suggests there is something you can do for high risk babies. Join us as we learn about an innovative test for eczema and what you might do with this information.  Our guest speakers are Dr. Anne-Sofie Halling who is completing a PhD on biomarkers of atopic dermatitis at Copenhagen University, Denmark; Prof. Alan Irvine a professor of dermatology at Trinity College, Dublin Ireland; and, Prof. Jonathan Hourihane a professor of pediatrics and child...
2022-12-0820 min
Eczema BreakthroughsIs it in your head? How to recognize and address the mental health impacts of eczemaUntil recently, the mental health impacts of eczema were hidden and under recognized. However, there's been a spate of new research that shows an association between eczema and mental health conditions like anxiety and depression. And those impacts extend to parents and caregivers as well.  Join the discussion with Dr. Mohammad Jafferany, Professor of Psychodermatology Psychiatry and Behavioral Sciences at Central Michigan University; Prof. Andrew Thompson, Professor of Clinical Psychology Cardiff University in the UK; and Dr. Katrina Abuabara, Associate Professor at University of California, San Francisco. A special thank you to Incyte, a member of GPER's Corporate Council, fo...
2022-10-0423 minEczema BreakthroughsPollution to pollen, floods to fires: how does climate change affect children with sensitive skin?Our skin protects us from our environment, and global warming is changing that environment. In turn, new research suggests this changing environment can alter our skin. In this episode we explore the impact climate change has on children with eczema and allergies. Our guests are: Dr. Mary Prunicki, Director of Air Pollution and Health Research at the Sean N Parker Centre for Allergy and Asthma Research, Stanford University; Dr. Marc Rothenberg, Director of Allergy and Immunology at Cincinnati Children’s Hospital; Dr. April Schachtel, chief of dermatology for the VA Puget Sound healthcare system in Washington State; and Dr. Mar...
2022-08-1024 minEczema BreakthroughsTopical Steroids: Game changer or double-edged sword? What does the research say?Topical corticosteroids (TCS) use is controversial in our community and generates a lot of concern among caregivers. Yet, it is the mainstay of eczema treatment for children and nearly every child who sees a doctor for eczema is likely using topical steroids. TCS do usually help with eczema symptoms, but it can be hard to wean off them and then there are side effects. In the first segment, we talk with dermatologist Dr. Steven Feldman from Wake Forest Baptist in North Carolina and two eczema parents who had very different experiences with topical corticosteroids. In the second segment, we discu...
2022-07-0626 minEczema BreakthroughsDo we dare dream of a future where eczema and food allergies can be prevented?Eczema and food allergy are closely intertwined, particularly when it comes to questions of prevention. We know that eczema tends to be the first condition to emerge in the atopic march and there is growing evidence that controlling eczema may actually prevent some of these downstream conditions. Likewise, if we can learn how to prevent eczema so that it never manifested in the first place, we may be able to prevent all of the conditions in the atopic march: food allergies, asthma and allergic rhinitis. Find out more on this episode, hosted in partnership with the Food Allergy Fund 2022 S...
2022-05-2633 min
dej_woîn - der steirische Wollpodcast#11 Philosophisches mit BuchvorstellungÜber den fibershed Teil 1
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2022-05-1914 minEczema BreakthroughsAre all moisturizers for eczema created equal? The answer appears to be no!Are certain types of moisturizers better than others for eczema? What is the best way to apply it? In this episode we ask our guest speakers, both researchers who have studied this topic, to weigh in: Dr. Tina Sindher, Clinical Associate Professor of Pediatrics from the Allergy and Clinical Immunology group at Stanford University and Dr. Ian Myles head of the Epithelial Therapeutics Unit at the National Institute of Allergy and Infectious Disease. P.S. If you like our podcast consider supporting it with a tax deductible donation.Research covered in this episode:Optimizing emollient th...
2022-04-2628 minEczema BreakthroughsLet's get real: Why are eczema patients struggling worldwide?Globally, patients and caregivers are often left to figure out the daunting task of getting eczema under control by medical systems that provide limited direction. In a first-of-its kind collaboration between patient organizations from eight countries coordinated by Global Parents for Eczema Research, we reveal the results of a 3,200 response survey which show how eczema patients are faring and to what extent medical care and treatments are meeting their needs. Our guests are Rachael Manion from the Canadian Skin Patient Alliance, Andrew Proctor from the National Eczema Society in the United Kingdom and Cheryl Talent from the Eczema Association of...
2022-04-0628 minEczema BreakthroughsA new menu of options for eczema: A first look at newly-approved treatmentsIn the last few months, a record FOUR new treatments have been approved for eczema in the United States, with other countries considering approval as well. At long last, kids with moderate-to-severe eczema will soon have new, effective options. What are these new treatments, their side effects and what do parents need to know about safety? Tune in as we discuss these emerging treatments with our expert guest speakers: Dr. Amy Paller, Professor of Pediatrics and Chair of the Department of Dermatology at Northwestern University, Chicago; and Dr. Aaron Drucker, Assistant Professor and Dermatologist at the University of Toronto...
2022-03-0222 minEczema BreakthroughsWhere do you turn to when you’re at the end of your rope? Mentorship and support for eczema parentsStudies by Global Parents for Eczema Research have shed light on the many mental health, quality of life, and life course impacts experienced by parents who care for children with moderate to severe eczema. The impacts are often hidden from view and take an enormous toll on caregivers who have the daunting challenge of controlling and managing eczema at all hours of the day and night, often without a break. Healthcare systems usually aren’t set up to address the needs of parents of children with serious medical issues. As a result, parents and caregivers are on their own, stre...
2022-02-1619 minEczema BreakthroughsThe surprising relationship between COVID risk & eczemaAt the beginning of the pandemic, the prevailing theory was that people with eczema would be at higher risk for COVID-19 infection and impacts because so many are using steroid treatments and also suffer from asthma, which many guessed would make respiratory infections worse. But, in a rare bit of good news, the exact opposite may be true! Tune in to learn how the immune system abnormalities associated with eczema may actually protect against COVID-19 infection and how one treatment may reduce the risk of severe symptoms after infection. Our guests are Dr. Emma Guttman-Yassky, Professor of Dermatology and...
2022-01-0727 minEczema BreakthroughsTo bathe or not to bathe, that is the question!Many parents receive conflicting advice about how and how often to bathe a child with eczema, which leads to confusion around this common ritual. On the one hand, baths can quell itch, and hydrate the skin prior to moisturization; on the other, over-bathing may actually dry out the skin and compromise the skin barrier. In this episode, we delve into the research on bathing and eczema with special guest Dr. Tom Marrs, a pediatric allergist at St Thomas Hospital in the United Kingdom. Dr. Marrs studies how the microbiome influences the development of allergic diseases. Research referenced...
2021-12-2230 minEczema BreakthroughsPassing the baton on eczema care from parent to childWhen children are young, parents have to manage their eczema care, and it’s a role that usually lasts a decade or more. But when children reach adolescence, parents must hand over the reins and learn to let go. In this episode we explore some pitfalls with this sometimes-tumultuous period as well as tips and best practices for navigating it with patience and skill. We examine the issues from the perspectives of both parents and young people. Our guest, Dr. Miriam Santer, studies this topic at University of Southampton. Tune in to learn more. Research men...
2021-09-2328 minEczema BreakthroughsFollow your gut! Can fecal microbiota transplants (FMT) be used to treat, or even cure, eczema?In this episode we explore the promise of an emerging therapy for inflammatory conditions like eczema: transplanting the fecal matter of a healthy person into the gut of a person with eczema. It sounds far-fetched (and even a little off-putting!) but this therapy has actually been around for 2000 years and was first used in ancient China to treat infections. More recently, FMT has been shown to cure difficult-to-treat intestinal infection and is emerging as a promising approach for a range of immune system related conditions (including eczema). Our guest is Dr. Siew Ng, a fecal microbiota transplant researcher with...
2021-08-1336 minEczema BreakthroughsFeed Babies Peanuts? The latest science on the intersection of eczema and food allergiesParents of children with eczema often end up on a long journey to determine what triggers their child’s flares, and food is often suspected to be a culprit. But restricting food too early can confuse the immune system and create problems later on. In this episode, co-hosted with Susan Weissman of the Food Allergy Fund (FAF) and produced as part of the FAF Annual Summit, we ask our panel of experts how and when to introduce foods like nuts, dairy, eggs, and wheat in children with eczema and what the implications are for the development of food allergy. Our...
2021-06-1426 minEczema BreakthroughsLearning Disability and EczemaNew research suggests a link between eczema and learning disabilities in children. But how can we tease out the effect of itch, sleep, treatment and other factors to know if the learning disability is real? Join us for this enlightening discussion with Dr. Joy Wan, dermatologist and researcher with Children’s Hospital of Philadelphia and lead author on a recently published study that looked at this complicated relationship. Research referenced in this episode:Association of Atopic Dermatitis Severity With Learning Disability in ChildrenIncreased attention-deficit/hyperactivity symptoms in atopic dermatitis are associated with his...
2021-05-1727 minEczema BreakthroughsThe Evolving Medicine Cabinet: What do we know about steroid creams and ointments? Plus a look at new “topical” medications on the horizon!In this episode we talk about parents’ concerns with topical steroids and what we do and don’t know about the risks and benefits of using this mainstay of treatment. We also explore NEW topical treatments for eczema that may be safer to use long term. Our guest is Dr. Elaine Siegfried, Director of the Division of Pediatric Dermatology At Saint Louis University and Cardinal Glennon Children’s Hospital and our co-host is parent Angela Tiru. Join us for a deep dive into all the controversial questions and more. Research referenced in this episode:Long-term safety...
2021-04-0223 minEczema BreakthroughsIt Takes Two To Tango: Exploring the Relationship Between Food Allergies and EczemaIn this episode we explore the bi-directional relationship between food allergies and eczema with two leading pediatric allergists.  Our guests are Dr. Anne Marie Singh, an allergy and immunology specialist with a focus in pediatrics with the University of Wisconsin School of Medicine and Public Health, and Dr. Peck Ong, Associate Professor of Clinical Pediatrics at the University of Southern California and attending physician in the Division of Clinical Immunology and Allergy at Children’s Hospital in Los Angeles. Our conversation explores how and when food allergies can trigger eczema as well as how eczema can serve as the gateway...
2020-11-2434 minEczema BreakthroughsDefining Eczema Types and Preparing for the Precision Medicine Revolution with Dr. Thomas BieberHow close are we to targeted treatments designed to each person with eczema? As parents, we often hear from people about a miracle approach that “cured” their or their child’s eczema, only to find that this same approach doesn’t work for us. We are continually reminded of the many different ways that eczema can appear and feel, and how people respond differently to different treatments. Right now, we have a largely “trial and error” approach to treating eczema but what will the future look like as we begin to understand eczema variation, subtypes, and personalized medicine? In this episode...
2020-10-1533 minEczema BreakthroughsTales from the Frontlines: Parents Share their Eczema Stories and Insights for World Atopic Eczema DayIn this episode six parents of children with eczema from around the world share common experiences, challenges and silver linings from their eczema journeys, and dispel myths and misperceptions about the condition. Join us for this special edition of Eczema Breakthroughs recorded for World Atopic Eczema Day (#atopiceczemaday), which takes place annually on September 14th. Episode 7 is co-hosted with Keri Kelley.
2020-09-1430 minEczema BreakthroughsNatural Killer CellsWhat do the Iditarod and the immune system have in common? How can we harness the body’s defenses for fighting off infections and invaders to tackle eczema and its complications, including eczema herpeticum.  Our guest for this episode of Eczema Breakthroughs is Dr. Brian Kim, Assistant Professor of Dermatology, Anesthesiology, Pathology and Immunology, and Co-Director of the Center for the Study of Itch at Washington University School of Medicine in St. Louis. His laboratory focuses on the immune mechanisms that underlie skin inflammation and the sensation of itch, and his groundbreaking translational research is showing new ways for address...
2020-08-2624 minEczema BreakthroughsDispatches from the frontlines of the "Battle of the Bacteria" with Dr. Richard GalloThere’s a battle underway on the skin between bacteria that make eczema worse and bacteria that can improve eczema symptoms. This fascinating discussion with Dr. Richard Gallo, Chairman of the Department of Dermatology at the University of California-San Diego, explains his ground-breaking research approach which amplifies the presence of “good” bacteria in order to control overgrowth of problematic strains, like Staph aureus, and ultimately help people with eczema. This podcast was recorded in 2018 as part of GPER’s research meetup series. Research referenced in this podcast:Eczema-associated bacteria may be kep...
2020-07-0724 minEczema BreakthroughsA Roadmap for Navigating the New Eczema Treatment Landscape with Dr. Eric SimpsonAlmost every week we hear about new treatments for eczema, many with names that are hard to pronounce and even harder to remember. After a long drought, we’re suddenly experiencing a downpour in new options, but for parents and patients, it’s hard to navigate this evolving landscape. Dr. Eric Simpson, a dermatologist with OHSU and leading expert on new eczema treatments, walks us through what’s new, what’s coming, and how to make sense of it all. Research referenced in this podcast:Systemic Immunomodulatory Treatments for Patients With Atopic DermatitisEfficacy...
2020-06-1626 minEczema BreakthroughsSystemic steroids? Antihistamines? A critical look at common treatment practices with Dr. Jonathan SilverbergOral and systemic steroids are used to treat eczema all the time, but are they safe and do they make sense for a long-term chronic disease? Antihistamines are the most commonly prescribed oral treatment for eczema, but do they actually address its symptoms? Dr. Jonathan Silverberg, a dermatologist and researcher with George Washington University, offers some straight talk in this episode of Eczema Breakthroughs. Tune in!Research referenced in this podcast:Comorbidities and the impact of atopic dermatitisUse of systemic corticosteroids for atopic dermatitisIncreased ADHD symptoms in atopic dermatitis...
2020-05-0730 minEczema BreakthroughsMessing with the Microbiome -- Insights from Dr. Ian MylesWhy is eczema prevalence on the rise? Are chemicals found in many skin and cosmetic products partially to blame? How do we restore a healthy balance of bacteria on eczema-prone skin? Is the idea that eczema is a “genetic” disease a myth? Learn more in this provocative chat with Dr. Ian Myles, a cutting-edge researcher with the NIH who studies “microbiome transplants” for the treatment of eczema.This episode was recorded, June 14th, 2019 as part of GPER’s Research Meetup series.Research referenced in the podcast:·     First-in-human Topical Microbiome Transplantation with Roseomonas Mucosa Bacteria·...
2020-03-2423 minEczema BreakthroughsA Dialogue with Dr. Peter LioCan you control itch with acupressure? Do toxins from bacteria drive eczema symptoms? What is the Dr. Aron Regimen and does it work? How should we think about long-term steroid use? Learn more in this interview with a Dr. Peter Lio, Assistant Professor of Dermatology and Pediatrics at Northwestern University Feinberg School of Medicine, Founding Director of the Chicago Integrative Eczema Center, and a true pioneer in eczema treatment and research.This episode was recorded August 16, 2016 as part of GPER’s Research Meetup series.Research referenced in the podcast:·     Acupressure study·     Review of alte...
2020-02-2027 min
Medizinische Fakultät - Digitale Hochschulschriften der LMU - Teil 18/19Der Östrogenrezeptor GPER im Hoden und in peritubulären Zellen
2015-10-0100 min
Medizin - Open Access LMU - Teil 22/22The G-Protein-Coupled Estrogen Receptor (GPER/GPR30) in Ovarian Granulosa Cell TumorsOvarian granulosa cell tumors (GCTs) are thought to arise from cells of the ovarian follicle and comprise a rare entity of ovarian masses. We recently identified the G-protein-coupled estrogen receptor (GPER/GPR30) to be present in granulosa cells, to be regulated by gonadotropins in epithelial ovarian cancer and to be differentially expressed throughout folliculogenesis. Thus, supposing a possible role of GPER in GCTs, this study aimed to analyze GPER in GCTs. GPER immunoreactivity in GCTs (n = 26; n (primary diagnosis) = 15, n (recurrence) = 11) was studied and correlated with the main clinicopathological variables. Positive GPER staining was identified in 53.8% (14/26) of GCTs and there...
2014-09-0100 min