Shows
In Silico Trials, Real Impacts!Digital Twins & Virtual Patients: Revolutionising Paediatric Clinical TrialsJoin us for an eye-opening exploration of how virtual patient data is revolutionising paediatric clinical trials. In our upcoming episode, we delve into groundbreaking research that addresses one of healthcare's most pressing challenges: the power crisis plaguing paediatric randomised controlled trials.
Discover how digital twins, synthetic patient data, and in silico trials are offering unprecedented solutions to reduce children's exposure to unproven therapies whilst accelerating drug approvals. We'll examine the transformative potential of these technologies in creating personalised treatment options at significantly lower costs, ultimately leading to faster clinical implementation of life-saving interventions.
However, innovation...
2025-06-3028 minIn Silico Trials, Real Impacts!Beyond the Scalpel: How Computer Models Are Rewriting Paediatric Heart SurgeryThis episode explores groundbreaking research from Boston Children's Hospital and Harvard Medical School that demonstrates how multiphysiologic state computational fluid dynamics (CFD) modelling is transforming surgical planning for children with complex congenital heart conditions.
We delve into the innovative 3D virtual surgery workflow developed for patients with single ventricle physiology and interrupted inferior vena cava - a particularly challenging combination that historically carries high risks of life-threatening complications. The research team's approach utilises advanced CFD analysis across multiple physiological states to predict and optimise hepatic venous flow distribution, preventing the formation of pulmonary arteriovenous malformations that can...
2025-06-2322 minIn Silico Trials, Real Impacts!Future-Proofing the UK Life Sciences SectorAre you prepared for the seismic shift transforming UK life sciences careers? This latest "In Silico Trials, Real Impacts!" episode reveals how AI and in silico technologies are creating unprecedented employment opportunities across health tech sectors.
Discover the essential skills driving this revolution, from computational biology to digital therapeutics, and why lifelong learning has become non-negotiable. We examine the geographical spread of emerging roles and explore how international talent maintains Britain's competitive advantage in global markets.
What does this transformation mean for traditional biologists, chemists, and clinicians as digital tools reshape their practice? How are g...
2025-06-1617 minIn Silico Trials, Real Impacts!Exploring the Limitations and Potentials of RCTs: Beyond the Gold Standard
Are Randomised Controlled Trials (RCTs) always the definitive 'gold standard' in research? In the latest episode of In Silico Trials, Real Impacts!, we explore the nuanced landscape of RCTs, questioning their universal applicability and examining the complexities they often obscure. While RCTs are celebrated for their rigour, this discussion delves into their limitations, particularly when findings are applied across diverse contexts.
Drawing on seminal work by Deaton and Cartwright (2018), this episode highlights the critical role that RCTs play in the medical and social sciences, while underscoring the importance of complementing them with observational studies and theoretical frameworks...
2025-06-0932 minIn Silico Trials, Real Impacts!Simpler or Complex: Rethinking Occam's Razor in Modelling ScienceIs simplicity always the smartest choice in science? Or could complexity be the key to groundbreaking discoveries? This episode explores the evolving role of simplicity and complexity in scientific modelling, questioning the age-old principle of Occam's razor in light of modern advancements: Plurality should not be posited without necessity.
Discover how digital approaches, from computational modelling to simulated clinical trials, are reshaping medical product development, making healthcare safer, more efficient, and unexpectedly precise. As we journey through recent research and breakthroughs, you'll gain insights into the tension between simple and complex scientific models, and how they impact t...
2025-06-0227 minIn Silico Trials, Real Impacts!Evaluating Continuous Glucose Monitoring Sensors with in Silico Trials: A Real-World ExemplarCould computer simulations redefine diabetes care? In this episode, we focus on a real medical product and the role of in silico trials in the transition from the Medtronic Guardian Sensor 3 to the Guardian 4 sensor, central to the Medtronic 780G pump system, which aims to simplify diabetes management by eliminating the need for fingerstick calibrations. Discover how computer simulations, clinical studies, and real-world data converge to evaluate this significant shift, revealing slight shifts in glucose metrics but proving the reliability of in silico methods in predicting real outcomes.
Join us to uncover the potential of digital modeling...
2025-05-2515 minIn Silico Trials, Real Impacts!Unveiling Evidence-Based Medicine Plus and Mechanistic Reasoning
What is Evidence-Based Medicine Plus? This podcast episode explores the transformative power of computational modelling and simulated clinical trials in medical innovation. Discover the significance of evidence-based medicine (EBM) and evidential pluralism, emphasising the role of mechanistic evidence alongside traditional studies. Join us as we delve into compelling examples like mobile phone radiation and ACE inhibitors, highlighting how these insights enhance the external validity of treatments. Perfect for researchers and regulators alike, or anyone interested in the evolving landscape of medicine.
Sources:
Russo F, Williamson J. Epistemic causality and evidence-based medicine. Hist Philos Life Sci. 2011;33(4):563...
2025-05-1916 minIn Silico Trials, Real Impacts!What Underpins Model Credibility? Three Philosophical PerspectivesHow do philosophers of science think about model evaluation? Dive deep into the crucial process of model evaluation, a fundamental step in digital science that determines the effectiveness and precision of computational models.
This episode explores three primary perspectives on model quality: the mirror view, relevant similarity, and fitness for purpose. Learn about the complexities and challenges involved in evaluating models, from data limitations to the intricate balance between accuracy and usability.
Whether you're a researcher, regulator, or a curious listener, discover how these cutting-edge methodologies are reshaping healthcare, improving safety, efficiency, and equitability, one...
2025-05-1219 minIn Silico Trials, Real Impacts!Exploring Digital Twins: The Philosophy Behind Healthcare's Digital RevolutionHave you ever wondered what makes a digital twin truly "twin-like" and not just another computer model? This fascinating question lies at the heart of modern healthcare innovation, where virtual copies of real-world systems are revolutionising how we approach medical research and patient care. Our latest episode delves into groundbreaking research that examines the philosophical underpinnings of digital twins, exploring what sets them apart from conventional computational models.
We unpack how digital twins are transforming healthcare through their unique ability to capture complex, emergent behaviours in ways traditional models cannot. From enabling safer drug development through in...
2025-05-0520 minIn Silico Trials, Real Impacts!Cracking the Code: Unveiling the Trustworthy World of In-Silico TrialsAre computational models ready to replace traditional clinical trials? This episode delves into the fascinating world of in silico trials and their growing role in regulatory evaluation of biomedical products. We explore a methodological framework based on the ASME VV-40-2018 standard that establishes credibility through verification, validation, and uncertainty quantification. From defining contextual use to conducting thorough risk analysis, we examine how these principles apply across statistical, machine learning, Bayesian, and agent-based models. We compare regulatory approaches between different authorities and make the case for wider adoption of credibility assessment standards to ensure reliable virtual evidence. Join us...
2025-04-2825 minIn Silico Trials, Real Impacts!Revolutionising Healthcare: The Power of Synthetic Data
Is the healthcare sector prepared to harness synthetic data's transformative potential whilst navigating its hidden pitfalls? This thought-provoking episode delves into the murky waters of synthetic data governance in medical research, examining how generative AI is reshaping our approach to patient information. As algorithms increasingly create convincing facsimiles of real clinical data, we explore the tantalising benefits—enhanced privacy protection, expanded research capabilities, and accelerated innovation cycles—alongside the concerning governance vacuum that threatens to undermine these advances. Our discussion unpacks why the absence of standardised creation and evaluation frameworks is stalling widespread adoption, despite synthetic data's promise. We make...
2025-04-2115 minIn Silico Trials, Real Impacts!How Can We Trust Computational Models in Healthcare? A Framework for In Silico Clinical TrialsAre you curious about how computer simulations are changing the way we evaluate medical devices? In this episode, we delve into the fascinating world of in silico clinical trials (ISCTs), a cutting-edge approach that uses computational models to assess the safety and effectiveness of medical interventions. We explore a recent paper that highlights the unique challenges of ensuring the credibility of ISCT results. The authors present a comprehensive workflow for assessing this credibility, drawing on various methodologies and frameworks, including those from the FDA. By reviewing a range of ISCT studies, we discuss innovative patient model generation techniques, the...
2025-04-1422 minIn Silico Trials, Real Impacts!How Can We Trust Computational Models in Healthcare? A Framework for In Silico Clinical TrialsAre we ready to replace human clinical trials with computer simulations? This provocative question sits at the heart of emerging in silico clinical trial (ISCT) methodologies for medical devices. As development costs soar and ethical considerations mount, computational models offer a tantalising alternative—but only if we can establish their credibility.
This episode explores a rigorous framework that could transform how we validate medical devices. Moving beyond traditional approaches, we'll examine how verification, validation, and uncertainty quantification (VVUQ) creates a pathway to trustworthy simulations. Unlike Bayesian methods, this framework employs a distinctive build-validate-predict structure that addresses epistemic un...
2025-04-1422 minIn Silico Trials, Real Impacts!Probability & Patients: The Stochastic Science Behind In Silico Trial Breakthroughs𝗪𝗵𝗮𝘁 𝗶𝗳 𝘁𝗵𝗲 𝗻𝗲𝘅𝘁 𝗰𝗹𝗶𝗻𝗶𝗰𝗮𝗹 𝘁𝗿𝗶𝗮𝗹 𝗯𝗿𝗲𝗮𝗸𝘁𝗵𝗿𝗼𝘂𝗴𝗵 𝗶𝘀 𝗮𝗹𝗿𝗲𝗮𝗱𝘆 𝗶𝗻 𝘆𝗼𝘂𝗿 𝗰𝗼𝗺𝗽𝘂𝘁𝗲𝗿? This episode explores the fascinating world of virtual patient models and stochastic engineering, unveiling how digital simulations are revolutionising healthcare clinical trials. Discover how simulated trials using sophisticated virtual patient models—complete with variations in age, body size, and disease progression—are introducing groundbreaking innovations in patient care.
We delve into stochastic engineering models that cleverly integrate uncertainty into device design, offering more precise and realistic predictions of clinical outcomes. Learn about the power prior method—a dynamic approach to combining digital and real-world evidence in clinical trials, enhancing efficiency and accelerating device delivery to patients whilst maintaining rigorous safety and accuracy standards.
Join us for an illuminating discussion at the cutting edge of healthcare innovation, where virtual modelling meets real-world pati...
2025-04-0713 minIn Silico Trials, Real Impacts!How can we properly evaluate the true economic impact of AI in healthcare?How are the CHEERS-AI guidelines transforming economic evaluations of healthcare AI? In our latest podcast episode, we delve into how the Consolidated Health Economic Evaluation Reporting Standards for AI (CHEERS-AI) are revolutionizing the economic assessment landscape for artificial intelligence in healthcare. Discover why transparency and consistency are crucial, and how this comprehensive framework helps determine the true financial value of AI innovations in the medical field.
This episode navigates the intricate challenges of healthcare AI integration, including uncovering hidden costs and addressing the "black box" problem—where understanding AI's decision-making processes remains difficult yet essential for proper ev...
2025-03-3123 minIn Silico Trials, Real Impacts!Revolutionising Healthcare: Inside the UK's MHRA Data StrategyWill the MHRA's New Data Strategy Transform Healthcare Through Computational Innovation? In this episode, we explore the MHRA's groundbreaking data strategy for 2024-2027, a visionary plan heralding a fourth industrial revolution in healthcare. From supporting data-driven innovation to harnessing AI and real-world evidence, we dive deep into the strategic themes aimed at revolutionizing medical product development and regulation.
Learn how AI is set to change the game, enabling quicker development of treatments tailored to individual needs and monitoring safety like never before. We also address the challenges of data fragmentation, quality issues, and privacy concerns, while highlighting...
2025-03-2417 minIn Silico Trials, Real Impacts!Unleashing the Potential of Health Data: Insights from the Sudlow ReviewWhat is the roadmap to transform how we use health data in the UK? This episode discusses the Sudlow Review and highlights the immense potential of linking health data, tackling accessibility challenges, and the importance of public trust. We discuss its five critical recommendations to make health data a national infrastructure, streamlining access, and ensuring ethical governance across the UK.
Whether you're a researcher, policy maker, or simply curious about the future of medical innovation, tune in to discover how harnessing health data can revolutionize patient care and healthcare research.
Source: Sudlow C (2024) Uniting Health...
2025-03-1721 minIn Silico Trials, Real Impacts!Regulatory Frontiers: UK's Centres of Excellence in Regulatory Science and InnovationHow is the UK positioning itself at the forefront of regulatory science innovation through strategic investments in centres of excellence? This episode explores the UK Government-funded Centres of Excellence in Regulatory Science and Innovation (CERSI) Initiative and its pivotal role in shaping the future regulatory landscape for AI and in silico technologies in healthcare. We examine two of the seven CERSIs funded by UK Government. Brunel University's critical work on building trust frameworks and ethical governance for AI applications, alongside the University of Manchester's groundbreaking advances in in silico clinical trials that promise to revolutionise drug development timelines and...
2025-03-1018 minIn Silico Trials, Real Impacts!Can NHS Secure Data Environments Unlock the Future of UK Life Sciences?Could NHS Data Environments Revolutionise UK Life Sciences Innovation? This episode focuses on the incredible potential of NHS data in revolutionising medical product development and regulation. The Association of the British Pharmaceutical Industry (ABPI) report, published in February 2025, investigates how to improve the regional Secure Data Environment (SDE) network to better serve the life sciences industry's research needs. The report outlines findings from a consultation with ABPI, ABHI, and BIA members regarding their use of NHS health data. It highlights key industry requirements for the SDE network, including the need for federated data access, streamlined governance, and commercially competitive ti...
2025-03-1040 minIn Silico Trials, Real Impacts!Virtual You vs Cancer: How Digital Twins Are Revolutionizing TreatmentWhat if your doctor could test hundreds of cancer treatments on a virtual version of your tumour before giving you a single dose of medication? In this episode, we dive into the fascinating concept of digital twins, particularly their application in oncology.
Discover how digital twins, virtual replicas of tumours, are being used to simulate treatment scenarios and predict outcomes, offering unprecedented precision in cancer care. Learn about the intricate process of creating these digital twins, from capturing medical imaging data to developing complex mathematical models. With insights tailored to the individual, digital twins represent the future...
2025-03-0322 minIn Silico Trials, Real Impacts!Digital Footprints to Medical Breakthroughs: The Real-World Data RevolutionWhat if the future of healthcare innovation lies not in controlled trials, but in the digital footprints we leave every day? Real-world data from health records, wearables, and patient experiences revolutionises medical research. This episode explores the profound impact of real world data (RWD) in healthcare.
Discover how everyday data sources like Fitbits, electronic health records (EHRs), and insurance claims are reshaping the medical landscape. Learn about the nuances of real world data, from its messy nature to its invaluable insights for patient care.
Dive into the complexities of data standardization, the use of machine...
2025-02-2419 minIn Silico Trials, Real Impacts!The Science Behind Making Virtual Trials Trustworthy: Ten RulesWould you trust a computer to help decide your medical treatment? Imagine doctors using virtual experiments to test treatments before giving them to real patients - sounds like sci-fi, right? But it's happening now! Just like pilots train in flight simulators before flying real planes, scientists are using powerful computer models to improve healthcare.
But here's the million-pound question: How do we know these digital predictions are reliable?
In this episode, we'll reveal the 10 golden rules scientists follow to ensure their virtual experiments are trustworthy. From making sure they're using the right data to having...
2025-02-1725 minIn Silico Trials, Real Impacts!STANDING Together: Equitable AI and In Silico Technologies in HealthcareWhat if In Silico Technologies in healthcare could truly serve everyone? The STANDING Together recommendations are revolutionising how we think about health data diversity and inclusion. From bustling cities to remote villages, discover how this groundbreaking initiative is reshaping healthcare technologies development through the voices of patients, practitioners, and policymakers. Join us as we explore the journey towards equitable healthcare technology that leaves no one behind
We'll explore the importance of data diversity and patient involvement in shaping the future of medical technology—be it AI diagnostic systems or in silico technologies predicting drug interactions. Understand how th...
2025-02-1012 minIn Silico Trials, Real Impacts!Can Computer Simulations Make Medical Products Safer?Ever wondered how we can make shoulder replacements safer without endless clinical trials? Step into the future of medical innovation where virtual patients help test new drugs and devices. Discover how computer simulations could make medicine safer, faster, and more ethical. Learn why experts believe digital trials might be the game-changer healthcare has been waiting for.
Viceconti M, Emili L, Afshari P, Courcelles E, Curreli C, Famaey N, Geris L, Horner M, Jori MC, Kulesza A, Loewe A, Neidlin M, Reiterer M, Rousseau CF, Russo G, Sonntag SJ, Voisin EM, Pappalardo F. Possible Contexts of Use for...
2025-02-0322 minIn Silico Trials, Real Impacts!Cutting Costs, Boosting Results: The Tech Revolution in Clinical TrialsWhy are clinical trials becoming so expensive? Dive into the financial maze of skyrocketing costs, from patient recruitment challenges to decentralization hurdles. Discover how patient-centric strategies and digital tools are reshaping the landscape, cutting costs, and boosting efficiency. Join us as we uncover the hidden drivers behind these rising expenses and explore innovative solutions to optimize clinical trials. Don't miss it!
DiMasi JA, Grabowski HG, Hansen RW. Innovation in the pharmaceutical industry: New estimates of R&D costs. J Health Econ. 2016 May;47:20-33.
Moore TJ, Heyward J, Anderson G, Alexander GC. Variation in the estimated...
2025-01-2715 minIn Silico Trials, Real Impacts!Breaking New Ground: The Virtual Trial Transforming Knee SurgeryCan 3D-printed, personalized knee surgery implants revolutionize arthritis treatment? Virtual clinical trials show promising results for a custom device that could make corrective knee surgery safer and more accessible. Discover how computer simulations are paving the way for the future of personalized orthopaedics.
MacLeod AR, Peckham N, Serrancolí G, Rombach I, Hourigan P, Mandalia VI, Toms AD, Fregly BJ, Gill HS. Personalised high tibial osteotomy has mechanical safety equivalent to generic device in a case-control in silico clinical trial. Commun Med (Lond). 2021 Jun 30;1:6. doi: 10.1038/s43856-021-00001-7.
2025-01-2012 minIn Silico Trials, Real Impacts!Standards as Innovation Catalysts: The PAGIT FrameworkHow can we unlock innovation while ensuring responsible governance? Dive into the evolution of the PAGIT framework, where standards meet strategic oversight. From disruptive technologies to incremental advances, discover how this groundbreaking approach is reshaping the UK's innovation landscape. Join us to explore how smart regulation and standards are building tomorrow's technological future.
Tait J (2024) The PAGIT framework: Its role in the governance of UK technologies to drive greater innovation, BSI, https://www.bsigroup.com/en-GB/insights-and-media/insights/whitepapers/update-to-pagit-framework-for-innovation.
2025-01-1337 minIn Silico Trials, Real Impacts!In Silico vs. Real Life: Can Computer Models Outperform Spine Surgery Tests?Can computers predict if medical devices are safe? Discover how virtual testing revolutionises surgical implant design, potentially saving millions in development costs and speeding up innovation. Learn how digital twins are helping bring safer bone screws to the operating room, faster than ever before.
Nagaraja S, Loughran G, Baumann AP, Kartikeya K, Horner M. Establishing finite element model credibility of a pedicle screw system under compression-bending: An end-to-end example of the ASME V&V 40 standard. Methods. 2024 May;225:74-88. doi: 10.1016/j.ymeth.2024.03.003.
2025-01-0616 minIn Silico Trials, Real Impacts!Heartware: Programming the Perfect HeartbeatThis week we ask: Can computers help us revolutionise heart failure treatment? Join us as we explore how computational modelling is transforming cardiac pacing therapy. Discover how virtual trials are accelerating research, optimising treatment strategies, and improving patient outcomes—all before a single device is implanted. Learn how this cutting-edge approach is helping clinicians identify the right treatment for the right patient, potentially changing the future of cardiac care. A fascinating intersection of computer science and cardiology you won't want to miss.
Strocchi M, Wijesuriya N, Mehta V, de Vere F, Rinaldi CA, Niederer SA. Computational Modelling Enabling In Silico Tri...
2024-12-3016 minIn Silico Trials, Real Impacts!Digital Twins Revolutionizing Shoulder Implant DesignEver wondered how we can make shoulder replacements safer without endless clinical trials? In today's episode, we dive into groundbreaking research that's revolutionising orthopaedic device testing through virtual simulations. We'll explore how researchers have developed a sophisticated computational model that predicts when shoulder implants might loosen – a critical concern in shoulder replacement surgery.
What makes this study fascinating is its dual-validation approach, which combines laboratory tests with real-world clinical data. We'll unpack how the team validated their virtual model using foam block experiments and actual patient outcomes, creating a bridge between controlled testing and clinical reality.
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2024-12-2221 minIn Silico Trials, Real Impacts!Enhancing UK Medicine RegulationCan the UK reclaim its crown as a clinical trials powerhouse? As Baroness Merron champions modernised regulations through Parliament, ABPI's candid assessment of MHRA reveals both progress and untapped potential. Join us in this bonus episode to explore how strategic reforms could transform the UK into a global life sciences leader.
Association of British Pharmaceutical Society (2024). Enhancing the role of UK medicine regulation. https://www.abpi.org.uk/publications/enhancing-the-role-of-uk-medicine-regulation
Baroness Merron (2024) Clinical Trials Regulations. Statement on UK Parliament 12-12-24. https://questions-statements.parliament.uk/written-statements/detail/2024-12-12/hlws306
2024-12-1618 minIn Silico Trials, Real Impacts!How Regulatory-Ready is Model-Informed Drug Development?Can we truly trust mathematical models to shape the future of medicine? In this episode, we explore the fascinating world of Model-Informed Drug Development (MIDD)—a game-changing approach that blends cutting-edge simulations with real-world data to revolutionise how drugs are developed and approved.
With the new ICH M15 Guideline, the global pharmaceutical landscape is moving towards a harmonised framework that ensures credibility, consistency, and trust in MIDD evidence. But how do these models hold up under scrutiny? And what does this mean for patient safety, regulatory decision-making, and the future of innovation in healthcare?
Join us...
2024-12-1610 minIn Silico Trials, Real Impacts!Shaping In Silico Medicine: The Power of Patient and Public InvolvementPublic and patient involvement (PPI) have a central role in advancing the adoption of in silico technologies. We explore insights from two pivotal documents: a position paper from the Avicenna Alliance advocating for a coordinated international approach to PPI in digital health and feedback from a UK public advisory panel that influenced a groundbreaking UK Centre of Excellence on In Silico Regulatory Science and Innovation initiative led by InSilicoUK. Join us as we uncover the challenges, successes, and actionable strategies driving cultural change and fostering collaboration between researchers, patients, and the public in this rapidly evolving field.
2024-12-0915 minIn Silico Trials, Real Impacts!Model-Informed Medicine Revolutionising Pregnancy PrescriptionsIn an era where precision matters most, computational modelling is reshaping how we approach medication during pregnancy. Join us as we explore groundbreaking research revealing how healthcare providers and expectant mothers are embracing mathematical simulations to tackle one of medicine's most complex challenges: safe and effective dosing during pregnancy. Discover why these sophisticated in silico approaches are gaining support in antenatal care, and what this means for the future of maternal-fetal medicine. We'll unpack the science, explore the stakeholder perspectives, and examine how these computational tools could transform pregnancy care from guesswork to precision medicine.
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2024-12-0218 minIn Silico Trials, Real Impacts!Can Synthetic Data Solve Healthcare's Bias Problems?Ever wondered how scientists test new treatments without real patients? Discover how cutting-edge technology creates 'virtual twins' for medical research, ensuring everyone's fairly represented. Learn how this groundbreaking approach revolutionises healthcare testing while keeping it safer and more inclusive for all.
Draghi B, Wang Z, Myles P, Tucker A. Identifying and handling data bias within primary healthcare data using synthetic data generators. Heliyon. 2024 Jan 10;10(2):e24164. doi: 10.1016/j.heliyon.2024.e24164.
2024-11-2517 minIn Silico Trials, Real Impacts!Revolutionising Drug Discovery with Digital TwinsThis week, we explore the ground-breaking potential of digital twins (DTs) to transform drug discovery and clinical trials. Generative AI, capable of creating realistic virtual representations of biological systems, is at the heart of this revolution. From simulating drug responses in individual cells to predicting patient outcomes in clinical trials, DTs promise to accelerate drug development and enhance precision medicine. We examine current applications and discuss challenges, including data scarcity and the need for greater model interpretability. Join us as we look ahead to the future of DTs, with a focus on multimodal and foundation models that offer a...
2024-11-1824 minIn Silico Trials, Real Impacts!Unlocking the Future of Medicines with PBPK ModellingIn this episode, we dive into the fascinating field of Physiologically Based Pharmacokinetic (PBPK) modelling, a revolutionary approach to transforming drug development. Discover how digital replicas of the human body are created to predict drug behaviour, offering a safer, more efficient, and more precise method for developing medications.
Explore the potential of PBPK to personalize medicine, reduce animal testing, and foresee long-term drug effects. Learn about the challenges and opportunities in this evolving field, and how it promises to reshape the future of healthcare.
Whether you're a researcher, regulator, or just curious about the future...
2024-11-1022 minIn Silico Trials, Real Impacts!Can Computer Simulations Provide Trustworthy Regulatory Evidence?This episode asks: Can computer simulations provide credible regulatory evidence?
Learn about the hierarchical framework that ensures the trustworthiness of virtual trials, using a Lego analogy to break down complex processes into manageable pieces. Understand how virtual devices, patients, and even surgeons are modelled to reflect real-world scenarios.
We also discuss the broader implications of this innovative framework and how it could lead to faster, more personalized, and more inclusive medical device development. Tune in to uncover the future of medicine and the role you can play in shaping it.
Aycock K...
2024-11-0421 minIn Silico Trials, Real Impacts!The Digital Revolution in Medical Imaging Trials: The VICTRE TrialIn this episode, we explore the fascinating world of in silico trials—a cutting-edge approach that could revolutionize how new medical technologies are tested and approved. Imagine conducting clinical trials entirely within a computer simulation, bypassing the need for expensive and time-consuming real-world testing. This futuristic-sounding method is already being utilized today, offering a glimpse into the future of healthcare.
We delve into a groundbreaking study that leveraged in silico trials to test a new breast cancer screening technology called Digital Breast Tomosynthesis (DBT). Unlike traditional mammograms, DBT provides a detailed 3D image of breast tissue, potentially im...
2024-10-2808 minIn Silico Trials, Real Impacts!Virtual Trials and the Future of Medical ImagingIn this episode, we embark on a journey into the world of virtual trials, particularly in the realm of medical imaging. Discover how digital twins—virtual replicas of human anatomy—are revolutionizing healthcare by offering safer, faster, and more efficient methods for testing new imaging technologies.
Learn about the incredible potential of virtual trials to optimize medical imaging techniques and personalize patient care. We discuss the challenges of accessibility, diversity, and reproducibility in this emerging field, and highlight the importance of collaboration among researchers, regulators, and patients.
Tune in to understand how virtual trials are not...
2024-10-2220 minIn Silico Trials, Real Impacts!Brain Aneurysms: A Self-Healing MysteryWelcome to Insilico Trials Real Impact, the podcast that's transforming our understanding of medical innovation.
This episode explores a medical phenomenon that sounds like science fiction: the possibility of brain aneurysms healing themselves through a process known as spontaneous thrombosis. We examine a groundbreaking study that uses advanced computer modeling to simulate blood flow in virtual patients, shedding light on how aneurysms may naturally seal off through clotting.
Listeners will learn about the factors influencing this self-repair mechanism, such as aneurysm size, shape, and blood pressure. Discover how these insights challenge traditional treatment approaches and o...
2024-10-1610 minIn Silico Trials, Real Impacts!The Brain's Hidden Power: Self-Healing AneurysmsEver wondered if your brain has the ability to heal itself? In this episode, we delve into a medical mystery that feels like science fiction: the phenomenon of spontaneous thrombosis, where brain aneurysms may naturally seal themselves off. Discover how researchers are using advanced computer modelling with virtual patients to explore this incredible process.
We explain the basics of aneurysms, likening them to weak spots in a garden hose, and explore how size and shape affect their ability to self-heal. Larger and taller aneurysms are more prone to clotting due to slower blood flow, much like a...
2024-10-1408 minIn Silico Trials, Real Impacts!In Silico Trials for Off-Label Use and Equitable EvidenceCan virtual patients revolutionise medical device testing? Our latest episode dives into groundbreaking in silico trials of the Pipeline Embolization Device for brain aneurysms. We'll explore how anatomical variations impact treatment success, and why this matters for equitable care. Join us to discover how computer simulations are paving the way for safer, more inclusive medical innovations. It's not just code – it's about saving lives fairly.
MacRaild M, Sarrami-Foroushani A, Song S, Liu Q, Kelly C, Ravikumar N, Patankar T, Lassila T, Taylor ZA, Frangi AF. Off-label in-silico flow diverter performance assessment in posterior communicating artery aneurysms. J...
2024-10-0608 min
Yale Certificate in Medical Software and Medical AI: Guest ExpertsIn Silico Trials of Medical Devices with Professor Alejandro Frangi FREngThis video is part of a series of guest expert interviews that we recorded for our new Yale Certificate Program on Medical Software and Medical AI – https://online.yale.edu/medical-software-ai-program.
Our guest is Prof Frangi is the Bicentennial Turing Chair in Computational Medicine at the University of Manchester, Manchester, UK, with joint appointments at the Schools of Computer Science and Health Sciences. He is also the Royal Academy of Engineering Chair in Emerging Technologies, with a focus on Precision Computational Medicine for in silico trials of medical devices. He is the Director of the Christabel Pankhurst In...
2024-09-2651 minIn Silico Trials, Real Impacts!Virtual Patients, Real Breakthroughs: FD-PASS and the Future of Medical Device TrialsOur latest episode explores FD-PASS, a virtual study that's revolutionising medical device testing. We'll unpack how this innovative approach simulated virtual patients to evaluate flow-diverting stents for intracranial aneurysms. Discover how FD-PASS not only mirrored real-world clinical trial results but also unveiled crucial insights into treatment failures. Could this be the future of medical research? Tune in to learn how virtual trials are reshaping the landscape of healthcare innovation and paving the way for more efficient, insightful studies.
Sarrami-Foroushani A, Lassila T, MacRaild M, Asquith J, Roes KCB, Byrne JV, Frangi AF. In-silico trial of i...
2024-09-2313 minIn Silico Trials, Real Impacts!Revolutionising Medical Device Development with In Silico Clinical TrialsWelcome to Insilico Trials Real Impact, the podcast that's transforming our understanding of medical innovation. Discover how in silico clinical trials are revolutionising medical device development! Join us as we explore how computer simulations are making healthcare safer, faster, and more accessible. From accelerating innovation to enhancing patient safety, learn how this groundbreaking approach is paving the way for more equitable care worldwide. Tune in to 'In Silico Trials, Real Impact!' – where virtual testing meets real-world breakthroughs!
2024-09-1609 min