Shows
Transformation in TrialsRevolutionizing Dentistry: AI and Research Innovation with Dr. Shervin MolayemSend us a textDr. Shervin Molayem shares his journey of innovation in dentistry, starting with his discovery of a connection between periodontal disease and COVID-19 severity that became the world's most-read dental article of 2020. He discusses groundbreaking technologies including AI-powered diagnostic tools and a revolutionary non-surgical treatment that regenerates bone tissue around teeth.• Discovered connection between gum disease and COVID-19 severity through interleukin-6 levels• Developing Trust AI, a dental co-pilot that gives practitioners instant access to research, bridging the 17-year gap between research and practice• AI dental diagnostics can detect 37% more pathology than h...2025-07-3038 min
Transformation in TrialsHow early diagnostics of lung cancer can lead to better survival rates with Chris WoodSend us a textChris Wood discusses how early diagnostics of lung cancer through artificial intelligence and medical imaging can lead to better survival rates through early intervention. • Lung cancer takes more lives than breast, prostate and colon cancer combined, with approximately 70% of cases caught at late stages• The National Lung Screening Trial showed that screening high-risk populations reduced mortality by 20%• I-ELCAP research demonstrated an 80% twenty-year survival rate for early-stage cancers detected with CT scans and treated surgically• Preventive healthcare is shifting from general advice to personalized screening protocols based on individual risk fact...2025-07-0236 min
Transformation in TrialsFrom Hopeless to High-Performing: Transforming Pharma Teams with Rajesh Anandan and Nechama KatanSend us a textBuilding high-performing teams in life sciences requires understanding how neurodiversity can be an advantage and designing work systems that enable different brain types to collaborate effectively.• A high-performing team continues to function when everything around it has fallen apart• Star players can become crutches that mask underlying team issues• Life sciences faces unique challenges: financial pressures, outdated technology, layoffs, and pervasive lack of trust• Teams often develop learned helplessness after years of having initiatives rejected• Only 10-15% of people are needed to drive revolutionary change in an organisati...2025-06-1853 min
Transformation in TrialsData Governance in the Age of Generative AI with Sebastian AndruszczakSend us a textSebastian Andruszczak, Chief Growth Officer at Holisticon (part of the Nexer Group), brings fresh perspective to the conversation around generative AI adoption in pharmaceutical companies. Drawing from his unique background in sales, marketing, and technology, Sebastian cuts through the hype to address fundamental challenges that prevent successful AI implementation in life sciences.The conversation reveals a critical insight often overlooked in the rush to adopt new technology: without proper data governance, organizations risk "scaling disaster." Sebastian walks us through the specific challenges pharmaceutical companies face - from ever-changing data sources creating...2025-06-0436 min
Transformation in TrialsPrevention Pays: How Technology Is Revolutionizing Mental Health with Eva PapadopoulouSend us a textWhy do we wait until we're severely unwell before seeking help? In this thought-provoking episode, I'm joined by Eva Papadopoulou, a mental health professional and expert in digital and AI-enabled healthcare solutions, to explore the transformative potential of preventative mental healthcare.Eva reveals the stark reality of our current healthcare systems - less than 10% of budgets are allocated to prevention, despite evidence showing preventative approaches lead to better outcomes and cost savings. Using dental care as a compelling example, she illustrates how cultural shifts can transform how we approach healthcare. "We...2025-05-2127 min
Transformation in TrialsCreating virtuous cycles in drug development with Rob FreishtatSend us a textRob Freistat, President of Uncommon Cures, discusses how clinical trials are transforming to accelerate drug development and ensure patients receive treatments faster, particularly in the rare disease space.• Current market uncertainty and investment challenges in biotech, especially for rare disease research• Approximately two-thirds of clinical trial processes add no value and aren't required by regulations• Many clinical trial failures occur not because drugs don't work but because trials can't recruit enough patients• Companies often treat development phases as "islands" rather than planning for commercial success from the beginning• Ra...2025-04-2345 min
Transformation in TrialsBridging Academia and Biotech: Creating Innovators of Tomorrow with Jonathon HillSend us a textJonathan Hill takes us on a fascinating journey through the cutting-edge world of DNA sequencing and its revolutionary potential for early disease detection. As both an academic professor at Brigham Young University and co-founder of Wasatch BioLabs, Hill shares how third-generation sequencing technologies are transforming our ability to identify diseases years before symptoms appear.The conversation centers on a groundbreaking approach using native methylation calling—a method that identifies specific chemical modifications to DNA—to detect neurodegeneration in conditions like Alzheimer's and Parkinson's. Hill explains how these diseases damage the brain for...2025-04-0932 min
Transformation in TrialsFrom Lab to Patient: Why Vector Design Makes or Breaks Cell Therapies with Alan GriffithSend us a textVectors are the unsung heroes of cell and gene therapy—molecular couriers that transport therapeutic genes into human cells to treat disease. But as Alan Griffith, Head of Global Operations at Vector Builder reveals, creating these sophisticated delivery vehicles is far more complex than most realize.Drawing from over a decade of experience developing gene therapies before joining the CDMO sector, Griffith offers rare insight into what makes manufacturing these therapies so challenging. Vector design emerges as the critical yet underappreciated factor determining success or failure. "The fundamental sequence and vector co...2025-03-2656 min
Transformation in TrialsTomorrow's Cures Are Hiding in Today's Patient Records with Vish SrivastavaSend us a textThe untapped potential of electronic health records has long been recognized in clinical research, but extracting meaningful insights from this treasure trove of data has remained an elusive challenge—until now.Vish Srivastava, founder of Century Health, reveals how artificial intelligence is revolutionizing real-world evidence by unlocking critical patient data trapped in EHRs. Traditional patient registries that once took a decade to amass just 1,000 patients can now be created with unprecedented efficiency through AI-powered data extraction. The breakthrough lies in advanced language models that can interpret unstructured clinical notes, transforming them in...2025-03-1224 min
Transformation in TrialsChampioning Diversity to Transform Clinical Research with Shelli PavoneSend us a textJoin us for a conversation with guest Shelli Pavone, co-founder of Inlightened, to uncover the untapped potential of diversity in clinical trials. Discover how historical mistrust, structural barriers, and exclusion criteria continue to hinder diverse patient recruitment. Shelli sheds light on the transformative impact inclusive trials have on scientific integrity, safety, and the generalizability of results. By embracing diversity, not only do we align with regulatory expectations, but we also pave the way for innovation and trust in our healthcare systems. This episode promises to expand your understanding of why diversity in trial...2025-02-2632 min
Transformation in TrialsRevolutionizing Neurological Care: Andreas Forsland and Gregg Johns on Assistive Technology and Brain-Computer InterfacesSend us a textIn this episode we dive into Brain-Computer Interface (BCI) technology, where the brain's faint signals are harnessed to create life-changing applications. Andreas Forsland and Greg Johns emphasize the importance of community-driven innovation, guided by the Brainiac Council—a unique assembly of patients, caregivers, and experts. This collaborative approach ensures that the solutions developed address real-world challenges, improving communication and independence for those with severe impairments. The discussion also highlights a groundbreaking clinical trial with the University of Waterloo, showcasing how AI-enhanced devices can reduce social isolation and enhance quality of life.We...2025-02-1256 min
Transformation in TrialsRevolutionizing Patient Recruitment in Clinical Trials: Unlocking Access and Accelerating Drug Development with Jill PellegrinoSend us a textThis episode reveals alarming statistics about patient access to clinical trials, highlighting that only 3% of patients currently have access to participate. Our guest, Jill Pellegrino, CEO of Auto Recruitment, shares innovative strategies to engage the other 90% of the patient population and discusses the importance of digital advertising, pre-screening, and patient support in the recruitment process.• Discussion on the low percentage of patient access to clinical trials • Barriers for physicians and research sites in patient enrollment • Strategies to engage patients through digital advertising • Importance of pre-screening for trial eligibility • The ro...2025-01-2229 min
Transformation in TrialsNavigating the Shift: From SAS to R in Clinical Trials with Sunil GuptaSend us a textWhy has SAS been the cornerstone of clinical trials for decades, and what is causing the shift to R now? Join us on "Transformation in Trials" as we explore this pivotal transition with Sunil Gupta, a seasoned programmer who has navigated both worlds. Sunil elaborates on SAS's long-standing dominance due to its robust programming capabilities and ease of use for FDA reviewers. However, the landscape is changing as R garners attention for its graphical prowess and collaborative potential. The conversation highlights the growing trend of new graduates versed in R and Python, which...2024-11-2034 min
Transformation in TrialsEnhancing Vendor Oversight and Communication Strategies in Clinical Trials with Jessica CordesSend us a textPrepare to transform your understanding of vendor oversight in clinical trials as we welcome Jessica Cordes, a senior consultant and trainer at the Clinical Excellence Consultancy. Jessica brings her wealth of experience to highlight the intricate responsibilities that sponsors must navigate when outsourcing tasks. Our conversation promises to equip you with insights on maintaining control, mitigating risks, and leveraging technology like AI and machine learning to future-proof your oversight strategies.Metrics are more than numbers—they're a lifeline in managing vendor relationships. Learn how robust oversight can impact patient safety and co...2024-11-1347 min
Maneuvering MondayChapter 6 Episode 3: The Final Episode with AK & IvannaSend us a textIn this final episode of Maneuvering Monday the podcast, AK and Ivanna wrap up everything and share the next steps for our book project.There is a bit of heavy breathing (sorry!) as we discuss Natalie and her trajectory, and how she ends up finally connecting with her purpose and passion after having suffered from 'The Peter Principle' throughout the story in her role as CEO at Zebra Apps. We talk about Anne and how she started off a bit arrogant, but ended up with good self-reflections (and a b...2024-11-0746 min
Transformation in TrialsNavigating Cell and Gene Therapy: Insights and Challenges with Dr. Bruce LevineSend us a textHow do you navigate the complexities of manufacturing cell and gene therapies that are tailored to individual patients? Find out as we sit down with Dr. Bruce Levine from the University of Pennsylvania to unpack the intricacies of clinical research in this groundbreaking field. From the unique emphasis on chemistry, manufacturing, and controls (CMC) to the logistical hurdles of sourcing and modifying patient-derived cells, Dr. Levine offers an expert's perspective on the challenges and advancements that set these therapies apart from traditional drugs. We also shine a light on the vital role of...2024-08-0734 min
Transformation in TrialsReconnecting with Purpose: Transforming Job Satisfaction and Patient Care in Life Sciences with Jill DonahueSend us a textWhat if re-engaging with your purpose could revolutionize your job satisfaction and mental health? Join us for our conversation with Jill Donahue, a leader in life sciences whose personal journey through psychology, behavioral science, and a profound personal tragedy has fueled her mission to improve communication and trust within the healthcare community. Jill opens up about how these experiences led her to create initiatives like her book "A Dose of Inspiration" and the Aurora Project, both aimed at fostering a deeper sense of purpose among life sciences professionals.Step into the...2024-07-1740 min
Transformation in TrialsRevolutionizing Clinical Trials: The Promise of AI and Predictive Analytics with Vinodh BalaramanSend us a textWhen nine out of ten clinical trials don't cross the finish line, it's time to ask tough questions and seek innovative answers. That's exactly the journey we embark on with Vinodh Balaraman from KolateAI in our latest podcast episode. Together, we unravel the complex knot of challenges that lead to clinical trial failures, from flawed study designs to enrollment obstacles and the unexpected curveballs thrown by the approval of competitor drugs. But it's not all doom and gloom; we shine a light on the potential of AI to bring about much-needed predictive capabilities...2024-07-1029 min
Transformation in TrialsExploring Patient-Centric Innovations in Digestive and Women's Health with Ariadna MasoSend us a textNavigating the tumultuous sea of inflammatory bowel disease (IBD) is no small feat, and Ariadna Maso of Sanno Health is our compass on this voyage. As the mastermind behind a company that's reshaping how we understand and manage gut health, Ari shares her intimate understanding of the patient's struggle, from the stinging uncertainty of diagnosis to the often overlooked psychological toll. Our conversation goes beyond the standard medication narrative and into the realm of holistic care, where anti-inflammatory diets and mental health support take center stage. Ari's insights into ongoing research illuminate a...2024-05-2938 min
Transformation in TrialsLarge Language Models in Clinical Trials with Eirini SchlosserSend us a textThis week we sit down with Erini Schlosser, CEO of Dyania Health, and chart the pioneering advancements in large language models within healthcare. This episode promises to reveal how the shift from simple entity recognition to sophisticated reasoning models has revolutionized drug discovery and the curation of electronic medical records, all while unpacking the challenges of data privacy, computational demands, and the hunt for specialized AI talent. Discover the fusion of technology and medicine where the collaborative potential for real-world data utilization in evidence-based studies emerges as a beacon for innovation amidst the...2024-04-0334 min
Transformation in TrialsThe Evolution of Clinical Trials Through Wearable Devices with Wessam SonbolSend us a textUncover how the seamless fusion of wearables with patient data is revolutionizing clinical trials in our latest conversation with Wessam Sonbol, the Founder and CEO of Delve Health. We navigate the transformation from cumbersome paper reporting to the sophisticated use of Patient Reported Outcomes and the continuous insights wearable technology offers. As we dissect the benefits and hurdles of this evolving data landscape, you’ll get an insider perspective on the intricacies of managing vast health metrics and setting benchmarks for impactful analysis. Plus, Wessam shares his knowledge on the reliability and strategic em...2024-03-2733 min
Transformation in TrialsInnovating Clinical Trial Design with Pierre Colin and Boaz AdlerSend us a textUnlock the secrets of clinical trial design with industry experts Pierre Colin and Boaz Adler as they join us for a deep dive into the early-stage planning that shapes the future of pharmaceuticals. They provide a look at the collaboration between clinicians, statisticians, and regulatory experts that's critical for determining the right patient populations, dosages, and study endpoints. With their guidance, we explore how statistical software and scenario planning play pivotal roles in estimating patient numbers, study durations, and costs, transforming clinical trial design into a fine art.As we navigate t...2024-03-131h 07
Transformation in TrialsMastering the Art of Clinical Trial Partnerships: Insights from Jason Gubb on Outsourcing and Co-CreationSend us a textEmbark on a journey through the dynamic landscape of clinical trial outsourcing with Jason Gubb, the co-founder of ClinOps Clarity and Emergent Teams. As we navigate the historical shift from predominantly in-house operations to the intricate web of external partnerships, Jason sheds light on the critical decision-making processes that shape the pharmaceutical and biotech industries. Grapple with the challenges and opportunities presented by R&D budget constraints and learn how emerging biotech firms are steering through fluctuating funding currents. Discover a world where the right choice of vendors can make or break a...2024-03-0636 min
Transformation in TrialsBreaking Barriers for Diversity in Clinical Trials with Sam WhitakerSend us a textIn this conversation with Sam Whitaker, we delve into the pivotal issues faced by underrepresented groups—particularly those from lower-income backgrounds—highlighting the disparity in current demographics and the consequences it bears on the reliability of drug efficacy and safety data for diverse populations. We go beyond the surface to examine the complexities surrounding compensation for trial participants, debunking the myth that stipends serve as an incentive and instead revealing the net financial loss many endure. With Sam's expertise, we explore why the current compensation structures pose significant barriers for those in lower-income brack...2024-02-2841 min
Transformation in Trials“Adaptive Clinical Trial Design: Large-Scale Study Simulation to Design for Results with Boaz AdlerSend us a textThis week we speak to Boaz Adler from Cytel's Software Division. This episode promises to illuminate the intricacies of trial design through the lens of Monte Carlo simulation, revealing how this potent approach crafts trials resilient to a myriad of scenarios. Boaz delves into the pivotal roles of interim monitoring and strategic market positioning post-trial, offering a masterclass in the art of clinical trial conception that withstands the test of uncertainty.As we navigate the vast landscape of clinical trial simulation, the topic of scale takes center stage. The conversation orbits...2023-12-2738 min
Transformation in TrialsTowards a more Agile Vendor Qualification: A Discussion with Dele Babalola and Rani NaikSend us a textEver wondered why the life sciences industry is stuck in redundant vendor qualification processes? Picture an organization where quality is designed rather than inspected. Yes, it's possible and we're about to paint that picture for you in this stimulating conversation with our guests, Dele Babalola and Rani Naik. They've got their fingers on the pulse of the GxP space and are ready to share their insights on the pressing need to evolve from redundant processes. Pay attention as Rani unfolds her unique vision for an agile, phase-appropriate quality organization. Imagine a w...2023-12-2049 min