Shows
Innovate and ReactChallenging HSAB: Reactive Molecules and Nucleophiles
Contributors:
Justus Reitz
Linkedin
Dr. Kevin Hares
LinkedIn
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Key takeaways:
Limitations of the HSAB Concept: While the HSAB (Hard and Soft Acids and Bases) concept is a familiar tool in chemistry for predicting reaction outcomes, it falls short as a reliable predictive model.
The Mayr Nucleophilicity Scale: The Mayr scale, a logarithmic measure, provides distinct numerical values to gauge nucleophile strength.
Stabilization of Reactive Intermediates: By employing super strong nucleophiles (like mesoionic olefins), the team was able to synthesize stable diazoalkenes, opening up new poss...
2025-04-0144 min