Shows
Innovate and ReactChallenging HSAB: Reactive Molecules and Nucleophiles
Contributors:
Justus Reitz
Linkedin
Dr. Kevin Hares
LinkedIn
Key takeaways:
Limitations of the HSAB Concept: While the HSAB (Hard and Soft Acids and Bases) concept is a familiar tool in chemistry for predicting reaction outcomes, it falls short as a reliable predictive model.
The Mayr Nucleophilicity Scale: The Mayr scale, a logarithmic measure, provides distinct numerical values to gauge nucleophile strength.
Stabilization of Reactive Intermediates: By employing super strong nucleophiles (like mesoionic olefins), the team was able to synthesize stable diazoalkenes, opening up new possibilities for investigating reaction mechanisms and functional group behavior.
Advancing Fundamental Research in Org...2025-04-0144 min