Shows
Evidence-Based GI: An ACG Publication and PodcastDirect-Acting Antiviral Therapy for Hepatitis C Virus Decreases All-Cause Mortality and Decompensated Cirrhosis: Treat (Virtually) EveryoneEditor-in-Chief Philip Schoenfeld, MD, MSEd, MScEpi FACG discusses “Association of Direct-Acting Antiviral Therapy with Liver and Nonliver Complications and Long-term Mortality in Patients with Chronic Hepatitis C,” by Ogawa E, Chien N, Kam L, et al. JAMA Internal Medicine [2023; 183: 97-105].
2023-02-2206 minEvidence-Based GI: An ACG Publication and PodcastEarly Colonoscopy for Acute Lower GI Bleeding Usually Is Not the AnswerShria Kumar, MD, MSCE and Editor-in-Chief Philip Schoenfeld, MD, MSEd, MScEpi FACG discuss “Timing of Colonoscopy in Acute Lower GI Bleeding: A Multicenter Retrospective Cohort Study,” by Shiratori Y, Ishii N, Tomonori A, et al. Gastrointest Endosc [2023; 97: 89-99].
2023-02-2210 minEvidence-Based GI: An ACG Publication and PodcastEndoscopic Sleeve Gastroplasty Is Effective for Patients with Obesity Who MERIT InterventionJennifer Kolb, MD, MS and Editor-in-Chief Philip Schoenfeld, MD, MSEd, MScEpi FACG discuss “Endoscopic Sleeve Gastroplasty for Treatment of Class 1 and 2 Obesity (MERIT), a Prospective, Multicentre, Randomised Trial,” by Dayyeh BKA, Bazerbachi F, Vargas EJ, et al. Lancet [2022; 400: 441-51].
2023-02-2210 minEvidence-Based GI: An ACG Publication and PodcastICYMI: Is Terlipressin for the Treatment of Hepato-Renal Syndrome Ready for Primetime: Results of the CONFIRM TrialEditor-in-Chief Philip Schoenfeld, MD, MSEd, MScEpi FACG and Sonali Paul, MD, MS discuss “Terlipressin plus Albumin for the Treatment of Type 1 Hepatorenal Syndrome,” by Wong F, Pappas SC, Curry KR, et al. N Engl J Med [2021; 384: 818-28].
2023-02-0308 minEvidence-Based GI: An ACG Publication and PodcastWhen It’s Not Acid Reflux: Managing PPI-Resistant GERD Patients Based on Bravo ResultsEditor-in-Chief Philip Schoenfeld, MD, MSEd, MScEpi FACG and Kristle Lee Lynch, MD discuss “Optimal Wireless Reflux Monitoring Metrics to Predict Discontinuation of Proton Pump Inhibitor Therapy,” by Yadlapati R, Gyawali CP, Masihi M, et al. Am J Gastroenterol [2022 Oct 1;117(10):1573-1582].
2023-01-2510 minEvidence-Based GI: An ACG Publication and PodcastRisankizumab, an Interleukin-23 Inhibitor, for Moderate-Severe Crohn’s Disease: Advancing Care Beyond Anti-TNF TherapyJessica Allegretti, MD, MPH and Editor-in-Chief Philip Schoenfeld, MD, MSEd, MScEpi FACG discuss “Risankizumab as maintenance therapy for moderately to severely active Crohn's disease: results from the multicentre, randomised, double-blind, placebo-controlled, withdrawal phase 3 FORTIFY maintenance trial,” by Ferrante M, Panaccione R, Baert F, et al. Lancet [2022 May 28;399(10340):2031-2046].
2023-01-2510 minEvidence-Based GI: An ACG Publication and PodcastContinuing Anti-TNF Agents past 24 Weeks of Pregnancy Associated with Fewer IBD Relapses with No Increase in Adverse Fetal OutcomesAhmad Abu-Heija, MBBS and Editor-in-Chief Philip Schoenfeld, MD, MSEd, MScEpi FACG discuss “Benefits and Risks Associated with Continuation of Anti-Tumor Necrosis Factor After 24 Weeks of Pregnancy in Women With Inflammatory Bowel Disease,” by Meyer A, Neumann A, Drouin J, et al. Ann Intern Med [2022; 175(10) 1374-82].
2022-12-1312 minEvidence-Based GI: An ACG Publication and PodcastNSAID Use and the Risk of IBD Exacerbations: Fact or FictionPhilip Okafor, MD, MPH and Editor-in-Chief Philip Schoenfeld, MD, MSEd, MScEpi FACG discuss “The Association Between Nonsteroidal Anti-Inflammatory Drug Use and Inflammatory Bowel Disease Exacerbations: A True Association or Residual Bias?” by Cohen-Mekelburg S, Van T, Wallace B, et al. Am J Gastroenterol [2022; 117 (11): 1851-57].
2022-12-1315 minEvidence-Based GI: An ACG Publication and PodcastReinvestigating the Lack of Association Between Proton Pump Inhibitor Use and Mortality by Accounting for Reverse CausationRavy Vajravelu, MD, MSCE and Editor-in-Chief Philip Schoenfeld, MD, MSEd, MScEpi FACG discuss “Association of Proton Pump Inhibitor Use With All-Cause and Cause-Specific Mortality,” by Lo CH, Ni P, Yan Y, et al. Gastroenterology [2022; 163:852 – 61].
2022-11-1124 minEvidence-Based GI: An ACG Publication and PodcastICYMI: Surgery is Superior to Medical Therapy for PPI-Refractory Heartburn in the “Right” PatientsJennifer Kolb, MD, MS and Editor-in-Chief Philip Schoenfeld, MD, MSEd, MScEpi FACG discuss “Randomized Trial of Medical versus Surgical Treatment for Refractory Heartburn,” by Spechler SJ, Hunter JG, Jones KM, et al. N Engl J Med [2019;381:1513-1523].
2022-11-1117 minEvidence-Based GI: An ACG Publication and PodcastVonoprazan, a Potassium-Channel Acid Blocker, is Superior to Lansoprazole for Managing Erosive EsophagitisEditor-in-Chief Philip Schoenfeld, MD, MSEd, MScEpi FACG discusses “Vonoprazan versus Lansoprazole for Healing and Maintenance of Healing of Erosive Esophagitis: A Randomized Trial,” by Laine L, DeVault K, Katz P, et al. Gastroenterology [2022; In Press].
2022-11-1113 minEvidence-Based GI: An ACG Publication and PodcastAcute pancreatitis: Need IV fluid resuscitation but avoid a WATERFALL!Shria Kumar, MD, MSCE and Editor-in-Chief Philip Schoenfeld, MD, MSEd, MScEpi FACG discuss “Aggressive or Moderate Fluid Resuscitation in Acute Pancreatitis,” by de-Madaria E, Buxbaum JL, Maisonneuve P, et al, published in N Engl J Med [2022;387(11):989-1000].
2022-10-1809 minEvidence-Based GI: An ACG Publication and PodcastHigh Adenoma Detection Rate Decreases Post-Colonoscopy CRC in FIT-Based Screening Program: Quality Matters!Joseph Sleiman, MD and Editor-in-Chief Philip Schoenfeld, MD, MSEd, MScEpi FACG discuss “Adenoma Detection Rate and Risk for Interval Postcolonoscopy Colorectal Cancer in Fecal Immunochemical Test-Based Screening: A Population-Based Cohort Study,” by Wisse PHA, Erler N, de Boer SY, et al, published in Ann Intern Med [2022; In Press].
2022-10-1818 minEvidence-Based GI: An ACG Publication and PodcastColonoscopy Reduces CRC Incidence and CRC-Related Mortality…. If You Get It!Editor-in-Chief Philip Schoenfeld, MD, MSEd, MScEpi FACG discusses “Effect of Colonoscopy Screening on Risks of Colorectal Cancer and Related Death,” by Bretthauer M, Løberg M, Wieszczy P, et al, published in N Engl J Med [Oct 9, 2022].
2022-10-1813 minEvidence-Based GI: An ACG Publication and PodcastTime to Increase Adenoma Detection Rate Benchmarks for Screening ColonoscopiesEditor-in-Chief Philip Schoenfeld, MD, MSEd, MScEpi FACG discusses “Pregnancy and Neonatal Outcomes After Fetal Exposure to Biologics and Thiopurines Among Women With Inflammatory Bowel Disease,” by Mahadevan U, Long MD, Kane SV, et al, published in Gastroenterology [2021 Mar;160(4):1131-1139].
2022-09-2122 minEvidence-Based GI: An ACG Publication and PodcastAchieve IBD Remission Before Pregnancy: PIANO Registry Data Shows Adverse Perinatal Outcomes For Infants Associated with IBD Flares and Steroid Use; and Continue Thiopurines and Anti-TNF Agents If Your IBD Patient Becomes PregnantEditor-in-Chief Philip Schoenfeld, MD, MSEd, MScEpi FACG discusses “Exposure to Corticosteroids in Pregnancy Is Associated with Adverse Perinatal Outcomes Among Infants of Mothers with Inflammatory Bowel Disease,” by Odufalu FD, Long MD, Lin K, Mahadaven U for PIANO Investigators, published in GUT [2022; 71: 1766-72] and also “Pregnancy and Neonatal Outcomes After Fetal Exposure to Biologics and Thiopurines Among Women With Inflammatory Bowel Disease,” by Mahadevan U, Long MD, Kane SV, et al, published in Gastroenterology [2021 Mar;160(4):1131-1139]
2022-09-2116 minEvidence-Based GI: An ACG Publication and PodcastICYMI-Pantoprazole Prophylaxis Does Not Reduce 90-day Mortality and Clinically Significant Adverse Events in ICU PatientsPhilip Okafor, MD, MPH and Editor-in-Chief Philip Schoenfeld, MD, MSEd, MScEpi FACG discuss “Pantoprazole in Patients at Risk for Gastrointestinal for Gastrointestinal Bleeding in the ICU,” by Krag M, Marker S, Perner A et al, published in NEJM [379; 23: 2018].
2022-09-2115 minEvidence-Based GI: An ACG Publication and PodcastTiny Polyps-It’s OK to Remove Polyps equal or less than 3mm with Large Biopsy ForcepsShria Kumar, MD, MSCE and Editor-in-Chief Philip Schoenfeld, MD, MSEd, MScEpi FACG discuss “Randomized Controlled Trial Investigating Cold Snare and Forceps Polypectomy Among Small POLYPs in Rates of Complete Resection: The TINYPOLYP Trial,” by Wei et al, published in Am J Gastroenterol [2022 Aug 1;117(8):1305-1310]. https://pubmed.ncbi.nlm.nih.gov/35467557/
2022-08-1112 minEvidence-Based GI: An ACG Publication and PodcastProphylactic Rifaximin Decreases Post-TIPS Hepatic EncephalopathyEditor-in-Chief Philip Schoenfeld, MD, MSEd, MScEpi FACG discusses “The Use of Rifaximin in the Prevention of Overt Hepatic Encephalopathy After Transjugular Intrahepatic Portosystemic Shunt : A Randomized Controlled Trial,” by Bureau et al, published in Ann Intern Med [2021 May;174(5):633-640].https://pubmed.ncbi.nlm.nih.gov/33524293/
2022-08-1112 minEvidence-Based GI: An ACG Publication and PodcastADR Isn’t the Only Game in Town: Proximal Serrated Lesion Detection Rates Predicts Interval Cancer RiskSwati Patel, MD, MS and Editor-in-Chief Philip Schoenfeld, MD, MSEd, MScEpi FACG discuss “Serrated polyp detection and risk of interval post-colonoscopy colorectal cancer: a population-based study,” by van Toledo et al, published in Lancet Gastroenterol Hepatol [2022 Aug;7(8):747-754]. https://pubmed.ncbi.nlm.nih.gov/35550250/
2022-08-1116 minEvidence-Based GI: An ACG Publication and PodcastSER-109, an Oral Microbiome Therapy, Decreases Recurrent Clostridiodes difficile InfectionAssociate Editor Jessica Allegretti, MD, MPH and Editor-in-Chief Philip Schoenfeld, MD, MSEd, MScEpi FACG discuss “SER-109, an Oral Microbiome Therapy for Recurrent Clostridioides difficile Infection” by Feuerstadt et al, published in N Engl J Med [2022;386(3):220-229]. https://pubmed.ncbi.nlm.nih.gov/35045228/
2022-06-1611 minEvidence-Based GI: An ACG Publication and PodcastWhen Is Routine Prophylactic Clipping Indicated Post-Polypectomy?Associate Editor Jeffrey Lee, MD, MPH and Editor-in-Chief Philip Schoenfeld, MD, MSEd, MScEpi FACG discuss “Effect of prophylactic endoscopic clip placement on clinically significant post-endoscopic mucosal resection bleeding in the right colon: a single-centre, randomised controlled trial” by Gupta et al, published in Lancet Gastroenterol Hepatol [2022;7(2):152-160]. https://pubmed.ncbi.nlm.nih.gov/34801133/
2022-06-0913 minEvidence-Based GI: An ACG Publication and PodcastTenapanor (IBSRELA) for Treatment of IBS-C: Effective over 26 WeeksEditor-in-Chief Philip Schoenfeld, MD, MSEd, MScEpi FACG discusses “Efficacy of Tenapanor in Treating Patients With Irritable Bowel Syndrome with Constipation: A 26-Week, Placebo-Controlled Phase 3 Trial (T3MPO-2)” by Chey et al, published in Am J Gastroenterol [2021;116: 1294-1303]. https://pubmed.ncbi.nlm.nih.gov/33337659/
2022-06-0211 minEvidence-Based GI: An ACG Publication and PodcastLow Grade Dysplasia in Barrett’s Esophagus – Get Two Expert GI Pathologist Reviews and Repeat EGD After PPI TreatmentAssociate Editor Shria Kumar, MD, MSCE and Editor-in-Chief Philip Schoenfeld, MD, MSEd, MScEpi FACG discuss “Discordance Among Pathologists in the United States and Europe in Diagnosis of Low-Grade Dysplasia for Patients With Barrett’s Esophagus” by Vennalaganti et al, published in Gastroenterology [2017 Feb;152(3):564-570.e4]. https://pubmed.ncbi.nlm.nih.gov/27818167/
2022-05-0515 minEvidence-Based GI: An ACG Publication and PodcastTherapeutic Drug Monitoring of Maintenance Infliximab Is Beneficial for Patients with Immunemediated Inflammatory DiseasesAssociate Editor Jessica R. Allegretti, MD, MPH and Editor-in-Chief Philip Schoenfeld, MD, MSEd, MScEpi FACG discuss “Effect of Therapeutic Drug Monitoring vs Standard Therapy During Maintenance Infliximab Therapy on Disease Control in Patients With Immune-Mediated Inflammatory Diseases: A Randomized Clinical Trial” by Syversen et al, published in JAMA [2021; 326(23):2375-2384]. https://pubmed.ncbi.nlm.nih.gov/34932077/
2022-04-1411 minEvidence-Based GI: An ACG Publication and PodcastEndoscopic Eradication Therapy for Neoplastic Barrett’s Esophagus Demonstrates 94% Treatment Success and Long-term DurabilityAssociate Editor Jennifer M Kolb MD, MS and Editor-in-Chief Philip Schoenfeld, MD, MSEd, MScEpi FACG discuss “Long-term Outcomes after Endoscopic Treatment for Barrett’s Neoplasia with Radiofrequency Ablation ± Endoscopic Resection: Results from the National Dutch Database in a 10-year Period” by Munster et al, published in Gut [2022;71:265-76]. https://pubmed.ncbi.nlm.nih.gov/33753417/
2022-04-0717 minEvidence-Based GI: An ACG Publication and PodcastIncreased Risk of Metachronous Neoplasia After Incomplete Polyp Resection – Time to CARE About Polypectomy Technique!Associate Editor Jeffrey Lee, MD, MPH and Editor-in-Chief Philip Schoenfeld, MD, MSEd, MScEpi FACG discuss “Recurrence of Colorectal Neoplastic Polyps After Incomplete Resection” by Pohl et al, published in Annals of Internal Medicine. [2021;174(10):1377-1384]. https://pubmed.ncbi.nlm.nih.gov/34370514/
2022-02-2417 minEvidence-Based GI: An ACG Publication and PodcastIt’s a Bad “Prep” Even Though the Patient Took It Correctly: Consider 15 mg Bisacodyl plus 4-Liter PEG Split Prep Before Next ColonoscopyEditor-in-Chief Philip Schoenfeld, MD, MSEd, MScEpi FACG discusses “A Multicenter Randomized Controlled Trial Comparing Bowel Cleansing Regimens for Colonoscopy After Failed Bowel Preparation” by Sey at al, published in Clinical Gastroenterology and Hepatology [2022;In Press]. https://pubmed.ncbi.nlm.nih.gov/34256147
2022-02-1713 minEvidence-Based GI: An ACG Publication and PodcastEffectiveness of Intermittent Fasting for Weight Loss: It’s Not Just When You Eat, but What You Eat, Too!Associate Editor Sonali Paul, MD, MS and Editor-in-Chief Philip Schoenfeld, MD, MSEd, MScEpi FACG discuss “Effects of Time-Restricted Eating on Weight Loss and Other Metabolic Parameters in Women and Men with Overweight and Obesity. The TREAT Randomized Clinical Trial” by Lowe et al, published in JAMA [2021; 181(6):883]. https://pubmed.ncbi.nlm.nih.gov/32986097/
2022-02-1017 minEvidence-Based GI: An ACG Publication and PodcastFamily Matters: Increased Risk of Colorectal Cancer among Individuals with Family History of PolypsAssociate Editor Ravy K. Vajravelu, MD, MSCE and Editor-in-Chief Philip Schoenfeld, MD, MSEd, MScEpi FACG discuss “Risk of colorectal cancer in first degree relatives of patients with colorectal polyps: nationwide case-control study in Sweden” by Song et al, published in BMJ [2021;373:n877]. https://pubmed.ncbi.nlm.nih.gov/33947661/
2022-02-0321 minEvidence-Based GI: An ACG Publication and PodcastSlow Down to Speed Up Quality: Longer Withdrawal Time of 9 Versus 6 Minutes Increases Adenoma Detection RateAssociate Editor Jennifer M. Kolb MD, MSCS and Editor-in-Chief Philip Schoenfeld, MD, MSEd, MScEpi, FACG discuss “Impact of 9-Minute Withdrawal Time on the Adenoma Detection Rate: A Multicenter Randomized Controlled Trial” by Zhao et al, published in Clinical Gastroenterology and Hepatology [2020;20:31553-6]. https://pubmed.ncbi.nlm.nih.gov/33220526/
2022-01-2720 minEvidence-Based GI: An ACG Publication and PodcastDrainage for Infected Pancreatic Necrosis – Earlier Is Not BetterAssociate Editor Shria Kumar, MD, MSCE and Editor-in-Chief Philip Schoenfeld, MD, MSEd, MScEpi, FACG discuss “Immediate versus Postponed Intervention for Infected Necrotizing Pancreatitis” by Boxhoorn et al, published in NEJM. [2021;15:1372-1381]. https://pubmed.ncbi.nlm.nih.gov/34614330/
2022-01-2016 minEvidence-Based GI: An ACG Publication and PodcastHereditary Syndrome Risk Assessment in all Colorectal Cancer Patients: Keep it Simple!Associate Editor Swati Patel, MD, MS and Editor-in-Chief Philip Schoenfeld, MD, MSEd, MScEpi, FACG discuss “Prospective Statewide Study of Universal Screening for Hereditary Colorectal Cancer: The Ohio Colorectal Cancer Prevention Initiative” by Pearlman et al, published in JCO Precision Oncology [2021;5:779-91]. https://pubmed.ncbi.nlm.nih.gov/34250417/
2022-01-1314 minEvidence-Based GI: An ACG Publication and PodcastTreating All the Symptoms of IBS-C: Linaclotide Significantly Decreases Abdominal Pain, Bloating, and DiscomfortAssociate Editor Jill Deutsch, MD and Editor-in-Chief Philip Schoenfeld, MD, MSEd, MScEpi, FACG discuss “Efficacy of Linaclotide in Reducing Abdominal Symptoms of Bloating, Discomfort, and Pain: A Phase 3B Trial Using a Novel Abdominal Scoring System” by Chang et al, published in American Journal of Gastroenterology [2021;116: 1929-37]. https://pubmed.ncbi.nlm.nih.gov/34465695/
2022-01-0617 minEvidence-Based GI: An ACG Publication and PodcastPiecemeal Cold Snare Polypectomy of Large SSP: Cold Is the New HotAssociate Editor Swati Patel, MD, MS and Editor-in-Chief Philip Schoenfeld, MD, MSEd, MScEpi, FACG discuss Piecemeal cold snare polypectomy versus conventional endoscopic mucosal resection for large sessile serrated lesions: a retrospective comparison across two successive periods bt Van Hattem WA, published in Gut [2021;70:1691-97]. https://doi.org/10.1136/gutjnl-2020-321753
2021-10-2814 minEvidence-Based GI: An ACG Publication and PodcastOnce-Weekly Semaglutide in Adults with Overweight or ObesityAssociate Editor Sonali Paul, MD, MS and Editor-in-Chief Philip Schoenfeld, MD, MSEd, MScEpi, FACG discuss Semaglutide Treatment Effect in People with Obesity (STEP) Investigators. Once-Weekly Semaglutide in Adults with Overweight or Obesity by Wilding et al, published in the New England Journal of Medicine [2021; 384: 989-1002. https://www.nejm.org/doi/10.1056/NEJMoa2032183
2021-10-2115 minEvidence-Based GI: An ACG Publication and PodcastScreening Colonoscopy Decreases Colorectal Cancer Incidence and Related Mortality in Healthy Patients Over 75Associate Editor Jeffrey Lee, MD, MPH and Editor-in-Chief Philip Schoenfeld, MD, MSEd, MScEpi, FACG discuss Association of Screening Lower Endoscopy with Colorectal Cancer Incidence and Mortality in Adults Older than 75 Years by Ma et al, published in .JAMA Oncology [2021;7(7):985-992]. https://doi.org/10.1001/jamaoncol.2021.1364
2021-10-1415 minEvidence-Based GI: An ACG Publication and PodcastAcute Myeloid Leukemia and Myelodysplastic Syndrome with IBD and Thiopurines Impact on RiskAssociate Editor Ravy K. Vajravelu, MD, MSCE and Editor-in-Chief Philip Schoenfeld, MD, MSEd, MScEpi, FACG discuss Incidence of Acute Myeloid Leukemia and Myelodysplastic Syndrome in Patients with Inflammatory Bowel Disease and the Impact of Thiopurines on Their Risk by Kahn et al., published in The American Journal of Gastroenterology [2021; 116: 741-47]. www.doi.org/10.14309/ajg.0000000000001058
2021-10-0713 min