Shows
The Human 5.0 ProjectBrain Immune Cells Control Anxiety: How Hoxb8 Microglia Shape OCD, Stress & Mental Health (2025 StudyMicroglia Are Controlling Your Anxiety — The Brain’s Hidden Immune Switch
What if anxiety, OCD, and chronic stress aren’t just “mental” — but immune disorders of the brain?
In this episode of The Human 5.0 Project, we break down groundbreaking 2025 research revealing that microglia — the brain’s immune cells — act as biological “brakes” or “accelerators” for anxiety and compulsive behavior. When these cells malfunction, anxiety and obsessive behaviors can spiral out of control.
Drawing from landmark work by Nobel laureate Mario Capecchi, this episode explores how Hoxb8 microglia regulate emotional behavior — and how dysfunction in this syste...
2025-12-2909 min
Choosing Science: Stories of Perseverance, Humanity, and SuccessProf. Dr. Mario Capecchi or how to go from being a homeless child to Nobel Prize winnerSend us a textMario Capecchi was one of the 3 scientists who were awarded the Nobel prize in Physiology or Medicine in 2007 “for their discoveries of principles for introducing specific gene modifications in mice by the use of embryonic stem cells”. However, him winning the most prestigious prize in science was not the most impressive thing he did in his life. For reference in terms of level of difficulty, it is somewhere above winning a Nobel prize and below surviving academic politics. He overcame abject poverty and homelessness as a child, with his earliest memory of his moth...
2025-07-2720 min
BGE presentsEp. 11/1/2024 - BGE presents Twin Teen Sibling Taekwondo Champs Overcome Bullying, Abuse & Racism to Excel In School, Serve Their Community, Form A Non-Profit. & Pen An Inspiring Book“In The Night Blooming, we provide motivation, techniques, outlets, encouragement, and empowerment to those who disbelieve in their abilities, says co-author Jonah Ismael. “We aim to turn their doubts into confidence, weakness into strength, and despair into power. We all have powers within us to rise and conquer any hardship that comes our way, and our mission is to further that message as far as we can through our book. Our book aims to inspire, empower, and advocate for the importance of believing in the capabilities we all have within ourselves, especially among the generation of our youth.”
Jonah and Sally...
2024-11-0100 min
Stories from the World of ScienceFrom War-Torn Streets to Nobel Laureate: The Extraordinary Journey of Mario CapecchiThis podcast tells the incredible life story of Mario Capecchi, a world-renowned geneticist and Nobel Prize winner. His journey began amidst the turmoil of World War II, where he experienced unimaginable hardship as a child. Abandoned and left to fend for himself on the streets of war-torn Italy, Capecchi endured hunger, illness, and witnessed traumatic events that left deep scars.
Despite these challenges, his spirit of resilience and survival shone through. After the war, he was reunited with his mother and immigrated to the United States, finding a supportive environment with his uncle...
2024-10-1609 min
La Domenica di Ameria RadioLa Domenica di Ameria Radio del 8 ottobre 2023 ore 18 - Insieme a… Gaetano Donizetti 5° puntataA cura di Paolo PellegriniElisir d’amoreSinfonia - Domingo HindoyanQuanto è bella – Giuseppe di StefanoBenedette queste carte – Mirella FreniCome Paride vezzoso – Ludovic TezierUna parola Adina - Jose Carreras e Pamela SouthUdite udite o rustici - Sesto Bruscantini Caro elisir... Esulti pur la barbara.. - Carlo Bergonzi e Renata ScottoVenti scudi? - Mariusz Kwiecień e Juan Diego FlorezBella Adina - Kathleen Battle y Enzo DaraPrendi per me sei libero - Mirella Fr...
2023-10-081h 09
U RisingUnraveling anxiety and OCD with Nobel Laureate Mario CapecchiA pandemic, social media, climate change—these are just some of the factors behind a dramatic rise in anxiety and depression in recent years. Now, in this conversation with U Rising host Julie Kiefer, Nobel Laureate Mario Capecchi shares exciting new research in mice that may shed light on mechanisms that control anxiety and obsessive-compulsive behaviors and lead to better treatments.Subscribe to the U Rising podcast on your favorite streaming platform, including Apple Podcasts, Spotify and Google Podcasts. You can also access episodes of U Rising on our news website, linked here.
2023-09-1214 min
Mind & MatterAnxiety, Obsessive Compulsive Disorder, Microglia, From Being a WWII Orphan to the Nobel Prize | Mario Capecchi | #125Dr. Mario Capecchi is a professor of genetics at the University of Utah & Nobel laureate. He discussed: his latest work in neurobiology, looking at the role of microglia in anxiety & Obsessive Compulsive Disorder (OCD); his Nobel Prize-winning work in molecular genetics; molecular biology & genetics; his childhood experiences as an orphan in Italy during World War II; immigrating to the US; his education & scientific career; his exercise & diet; advice for aspiring scientists; and more.* Click here to download audio, watch video, or read show notes & transcripts. * If you enjoy my content and want to further support M...
2023-08-211h 41
Mind & MatterAnxiety, Obsessive Compulsive Disorder, Microglia, From Being a WWII Orphan to the Nobel Prize | Mario Capecchi | 125Send us a textDr. Mario Capecchi is a professor of genetics at the University of Utah & Nobel laureate. He discussed: his latest work in neurobiology, looking at the role of microglia in anxiety & Obsessive Compulsive Disorder (OCD); his Nobel Prize-winning work in molecular genetics; molecular biology & genetics; his childhood experiences as an orphan in Italy during World War II; immigrating to the US; his education & scientific career; his exercise & diet; advice for aspiring scientists; and more.*Not medical advice.Support the showHealth Products by M...
2023-08-211h 41
Goddess Rising PodcastHealing from CPTSDOn today's episode we are interviewing the lovely Linnea Butler who is a trauma therapist and founder of The Bay Area Mental Health where she helps people with complex trauma. We discuss her journey on how she went from being successful in marketing climbing the corporate ladder to no longer being fulfilled by that career and switching roles to become a trauma therapist. The more inner work she did the more in touch she became with what was important to her and aligned with her soul. Tune in to listen to her journey, experience and everything in between!
2023-03-1326 min
Viaje a Ítaca PodcastEntrevista a Mario Colleoni, traductor de "Poesías en Casarsa", de Pier Paolo Pasolini (SOMOS LIBROS) 15-10-2022Responsable de la edición y traducción del poemario con el que debutó Pasolini, Mario Colleoni nos presenta esta obra con la que se inició la trayectoria de uno de los grandes creadores del siglo XX.
*Música: 'Jolicoeur', del álbum "Canti Popolari Italiani" (Renato Capecchi, 2000). ' I ragazzi giù nel campo', del álbum "Le Canzoni Di Pier Paolo Pasolini", (Aisha Cerami, Nuccio Siano y Roberto Marino, 2007).
Entrevista emitida en El Prat Ràdio el sábado 15 de octubre de 2022.
2022-10-1838 minViaje a Ítaca PodcastEntrevista a Mario Colleoni, traductor de "Poesías en Casarsa", de Pier Paolo Pasolini (SOMOS LIBROS) 15-10-2022Responsable de la edición y traducción del poemario con el que debutó Pasolini, Mario Colleoni nos presenta esta obra con la que se inició la trayectoria de uno de los grandes creadores del siglo XX.
*Música: 'Jolicoeur', del álbum "Canti Popolari Italiani" (Renato Capecchi, 2000). ' I ragazzi giù nel campo', del álbum "Le Canzoni Di Pier Paolo Pasolini", (Aisha Cerami, Nuccio Siano y Roberto Marino, 2007).
Entrevista emitida en El Prat Ràdio el sábado 15 de octubre de 2022.
2022-10-1838 min
L'OperaL'Opera 80 - 100 ANNI RENATA TEBALDI - G. Verdi "La Forza del Destino"Leonora di Vargas, Renata Tebaldi (debutto)Don Alvaro, Mario Del MonacoDon Carlo di Vargas, Aldo ProttiPreziosilla, Fedora Barbieriil Padre Guardiano, Cesare SiepiFra’ Melitone, Renato Capecchiil Marchese di Calatrava, Silvio MajonicaCurra, Angela VercelliMastro Trabuco, Piero De Palmaun Alcalde, Giorgio Giorgettiun Chirurgo, Walter FinessiCoro e Orchestra del Maggio Musicale FiorentinoDimitri Mitropoulos, direttore
2022-05-292h 57
Science on the Side7. It's in His GenesJoin Ty and Morgan as they tell the incredible true story of Mario Capecchi, Nobel Laureate from the University of Utah. Not only is his prize-winning discovery of knockout gene technology revolutionary to medical and genetic research, but his life story is inspiring to all.
2021-12-2247 min
Annual ReviewsA Conversation with Oliver SmithiesProfessor Oliver Smithies is the Weatherspoon Eminent Distinguished Professor of Pathology and Laboratory Medicine at the University of North Carolina, Chapel Hill. Along with Mario Capecchi and Martin Evans, Oliver was awarded the Nobel Prize in Medicine in Physiology or Medicine in 2007 for his contributions to the development of gene targeting using homologous recombination in embryonic stem cells. This technique has had an immense impact on biomedical research over the past two decades. Professor Smithies has had a long and distinguished career as a researcher and mentor. Here, he engages in an entertaining and enlightening discussion of his life in...
2015-02-0949 min
Annual Reviews ConversationsA Conversation with Oliver SmithiesProfessor Oliver Smithies is the Weatherspoon Eminent Distinguished Professor of Pathology and Laboratory Medicine at the University of North Carolina, Chapel Hill. Along with Mario Capecchi and Martin Evans, Oliver was awarded the Nobel Prize in Medicine in Physiology or Medicine in 2007 for his contributions to the development of gene targeting using homologous recombination in embryonic stem cells. This technique has had an immense impact on biomedical research over the past two decades. Professor Smithies has had a long and distinguished career as a researcher and mentor. Here, he engages in an entertaining and enlightening discussion of his life...
2015-02-0649 min
College of Phys/MathMario R. Capecchi 2014 Izatt-Christensen PodcastMario R. Capecchi 2014 Izatt-Christensen Podcast by College of Phys/Math
2014-01-1515 min
Pop-Up IdeasTim Harford: Hotpants vs The Knockout MouseTim Harford weaves together economic ideas with remarkable personal histories in some unusual locations. The presenter of Radio 4's More or Less speaks to an audience from a shop window on London's Regent Street, and turns his attention to heated pants and the business of innovation. He tells the moving story of Mario Capecchi, whose struggle to get funding for his experiments tells us much about where new ideas come from, and how to foster them.
2013-01-1613 min
Futures in Biotech (Video)How to Use a Mouse
Nobel Laureate Dr. Mario Capecchi teaches us how to use a mouse to dissect the human genome and understand disease.
Our guest is Mario Capecchi, Ph.D., distinguished Professor of Human Genetics and Biology at the University of Utah and investigator with the Howard Hughes Medical Institute
Host: Marc Pelletier
Guest: Mario Capecchi, Ph.D.
For a free audiobook, visit Audible.com/biotech.
Thanks to Phil Pelletier and Will Hall for the great themes.
Thanks to CacheFly for providing the bandwidth for this netcast.
2010-07-0350 min
Futures in Biotech (Audio)How to Use a Mouse
Nobel Laureate Dr. Mario Capecchi teaches us how to use a mouse to dissect the human genome and understand disease.
Our guest is Mario Capecchi, Ph.D., distinguished Professor of Human Genetics and Biology at the University of Utah and investigator with the Howard Hughes Medical Institute
Host: Marc Pelletier
Guest: Mario Capecchi, Ph.D.
For a free audiobook, visit Audible.com/biotech.
Thanks to Phil Pelletier and Will Hall for the great themes.
Thanks to CacheFly for providing the bandwidth for this netcast.
2010-07-0350 min
Neuroscientists Talk ShopEpisode 12 -- Mario Capecchi, PhDMonday, April 14, 2008
2007 Nobel Laureate Mario Capecchi, (co-Chair, Dept of Human Genetics, University of Utah) discusses the impact of his seminal gene targeting work on the future of neuroscience in a discussion hosted by Gary Gaufo.
Additional Links:
Nobel Lecture
Capecchi Laboratory
Duration: 58 minutes
Discussants:(in alphabetical order)
Edwin Barea-Rodriguez (Assoc Prof, UTSA)
Gary Gaufo (Asst Prof, UTSA)
Brian Derrick (Assoc Prof, UTSA)
Carlos Paladini (Asst Prof, UTSA)
Salma Quraishi (Research Coord, UTSA)
Rama Ratnam (Asst...
2008-04-1457 min
Desert Island DiscsMartin EvansKirsty Young's castaway this week is the Nobel Prize-winning scientist Professor Sir Martin Evans. He is known as the grandfather of embryonic stem-cell research because of the breakthrough he made more than 25 years ago to first isolate the stem cells of mice and then cultivate them in a laboratory. After that leap forward, he worked alongside his fellow Nobel laureates Oliver Smithies and Mario Capecchi to develop the Knock-Out Mouse - a mouse that has had part of its genetic code disabled so the effect on the animal can be studied. The Knock-Out Mouse has become a scientific tool...
2008-02-1735 min
Desert Island Discs: Archive 2005-2010Martin EvansKirsty Young's castaway this week is the Nobel Prize-winning scientist Professor Sir Martin Evans. He is known as the grandfather of embryonic stem-cell research because of the breakthrough he made more than 25 years ago to first isolate the stem cells of mice and then cultivate them in a laboratory. After that leap forward, he worked alongside his fellow Nobel laureates Oliver Smithies and Mario Capecchi to develop the Knock-Out Mouse - a mouse that has had part of its genetic code disabled so the effect on the animal can be studied. The Knock-Out Mouse has become a scientific tool...
2008-02-1735 min
Unnatural Acts of OperaLa forza del destino (Verdi) Act 4Renata Tebaldi (Leonora), Fedora Barbieri (Preziosilla), Mario del Monaco (Alvaro), Aldo Protti (Carlo), Renato Capecchi (Melitone), Cesare Siepi (Guardiano), Teatro Communale di Firenze, Dimitri Mitropoulos. June 3, 1953.
2006-07-1356 minUnnatural Acts of OperaLa forza del destino (Verdi) Act 3Renata Tebaldi (Leonora), Fedora Barbieri (Preziosilla), Mario del Monaco (Alvaro), Aldo Protti (Carlo), Renato Capecchi (Melitone), Cesare Siepi (Guardiano), Teatro Communale di Firenze, Dimitri Mitropoulos. June 3, 1953.
2006-07-111h 02Unnatural Acts of OperaLa forza del destino (Verdi) Act 2Renata Tebaldi (Leonora), Fedora Barbieri (Preziosilla), Mario del Monaco (Alvaro), Aldo Protti (Carlo), Renato Capecchi (Melitone), Cesare Siepi (Guardiano), Teatro Communale di Firenze, Dimitri Mitropoulos. June 3, 1953.
2006-07-081h 05Unnatural Acts of OperaLa forza del destino (Verdi) Act 1The hand of fate gives little JJ his big chance, when he gets to introduce this podcast. Renata Tebaldi (Leonora), Fedora Barbieri (Preziosilla), Mario del Monaco (Alvaro), Aldo Protti (Carlo), Renato Capecchi (Melitone), Cesare Siepi (Guardiano), Teatro Communale di Firenze, Dimitri Mitropoulos. Ju...
2006-07-0630 min