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Mark Ebell

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Primary Care Update
Primary Care UpdateEpisode 194: CBD safety, HTN guideline, choosing DM drugs, and COVID-19 vax efficacyThis week primary care physicians Gary, Henry, Kate and Mark discuss the safety of CBD, a new guideline for managing adults with hypertension, whether COVID-19 vaccines are still effective, and a living guideline from the BMJ to help us choose the best diabetes drugs. Links to stuffEssential Evidence Plus Illinois Academy of Family Physicians meeting Dec 6 in Naperville, IL (Kate, Gary and Mark)   North Dakota Academy of Family Physicians Big Sky Conference Jan 19 in Big Sky, Montana (Gary and Kate) Safety of CBDACC/AHA Hypertension g...
2025-11-2632 minPrimary Care Update
Primary Care UpdateEpisode 193: Intensive BP lowering, elinzanetant for VMS, HTN in pregnancy and prostate CA screeningPrimary care physicians Gary Ferenchick, Kate Rowland, Henry Barry and Mark Ebell want you to know about 4 new studies: the best choice of pharmacotherapy in hypertensive disorders of pregnancy, benefits and harms of intensive BP lowering, elinzanetant for therapy-induced vasomotor symptoms in women with breast cancer, and 23 year follow up of the European Prostate Cancer Screening Trial. Plus a confusing quiz question (thanks Gary!).LinksEssential Evidence Plus: www.essentialevidenceplus.comHTN in pregnancy: https://pubmed.ncbi.nlm.nih.gov/40216176/Intensive BP lowering: https://pubmed.ncbi.nlm.nih.gov/40902616/ ...
2025-11-1238 minPrimary Care Update
Primary Care UpdateEpisode 191: acetaminophen, leucovorin, MMR and autism; the value of primary careThis week, primary care physicians Kate Rowland, Mark Ebell, and Henry Barry want to arm our primary care colleagues with the best evidence on whether acetaminophen causes autism, whether MMR causes autism, and whether leucovorin can treat autism. Gary then turns to a study of the value of continuity in primary care, and its association with better health outcomes.Links:Henry's essay on Ignaz Semelweis, handwashing, and postage stamps: https://thestampforum.boards.net/thread/13044/current-issue-volume-jul-2025 Essential Evidence Plus and POEMs: www.essentialevidenceplus.comAcetaminophen in pregnancy and autism: https://www.ncbi...
2025-10-1930 minPrimary Care POEM of the Week with Drs. Mark Ebell and Mike Wilkes
Primary Care POEM of the Week with Drs. Mark Ebell and Mike WilkesEpisode 10: Are skeletal muscle relaxants effective for chronic pain?Listen as Drs. Mike Wilkes and Mark Ebell discuss a new systematic review that found some conditions for which skeletal muscle relaxants are effective, and others for which they are not.
2025-02-1006 minPrimary Care POEM of the Week with Drs. Mark Ebell and Mike Wilkes
Primary Care POEM of the Week with Drs. Mark Ebell and Mike WilkesEpisode 9: After an MI, should beta-blockers be continued long-term?Join Drs. Ebell and Wilkes as they discuss this weeks POEM. It addresses the question of whether beta-blockers should be continued indefinitely after a myocardial infarction.
2025-01-2806 minPrimary Care POEM of the Week with Drs. Mark Ebell and Mike Wilkes
Primary Care POEM of the Week with Drs. Mark Ebell and Mike WilkesEpisode 8: E-cigarettes can help people quit smokingJoin Drs. Mike Wilkes and Mark Ebell as they discuss the use of e-cigarettes to help people quit smoking.
2025-01-0605 minPrimary Care POEM of the Week with Drs. Mark Ebell and Mike Wilkes
Primary Care POEM of the Week with Drs. Mark Ebell and Mike WilkesEpisode 7: Self-guided digital behavioral therapy for fibromyalgiaJoin Drs. Mike Wilkes and Mark Ebell as they discuss digital behavioral therapy to treat symptoms of fibromyalgia: Gendreau RM, McCracken LM, Williams DA, et al. Self-guided digital behavioural therapy versus active control for fibromyalgia (PROSPER-FM): A phase 3, multicentre, randomised controlled trial. Lancet 2024;404(10450):364-374. 
2024-12-2505 minPrimary Care POEM of the Week with Drs. Mark Ebell and Mike Wilkes
Primary Care POEM of the Week with Drs. Mark Ebell and Mike WilkesEpisode 6: Probiotics reduce likelihood of frequent UTIsJoin Drs. Mike Wilkes and Mark Ebell as they discuss a new randomized trial of probiotics for UTI: Gupta V, Mastromarino P, Garg R. Effectiveness of prophylactic oral and/or vaginal probiotic supplementation in the prevention of recurrent urinary tract infections: A randomized, double-blind, placebo-controlled trial. Clin Infect Dis 2024;78(5):1154-1161.
2024-12-2505 minPrimary Care POEM of the Week with Drs. Mark Ebell and Mike Wilkes
Primary Care POEM of the Week with Drs. Mark Ebell and Mike WilkesEpisode 5: SGLT2 inhibitors reduce CV mortalityThis week, Drs Wilkes and Ebell discuss a new meta-analysis of the CV benefit of SGLT-2 inhibitors, which is less dramatic than you might think.
2024-11-2507 minPrimary Care POEM of the Week with Drs. Mark Ebell and Mike Wilkes
Primary Care POEM of the Week with Drs. Mark Ebell and Mike WilkesEpisode 3: Consequences of UTIs in childrenThis week primary care Drs. Wilkes and Ebell talk about the long term harms of multiple UTIs in children.
2024-10-2206 minPrimary Care POEM of the Week with Drs. Mark Ebell and Mike Wilkes
Primary Care POEM of the Week with Drs. Mark Ebell and Mike WilkesEpisode 1: Current mortality in flu, RSV and COVID-19Join primary care physicians Drs. Mike Wilkes and Mark Ebell as they discuss the comparative death rates for patients hospitalized with influenza, RSV and COVID-19
2024-10-1108 minPrimary Care Update
Primary Care UpdateEpisode 161: Antibiotics for CAP, melatonin for delirium, screening for lung disease, and seizures after COVID vaccineThis week, join Kate, Gary, Mark and Henry as they discuss screening asymptomatic people for COPD and asthma, the rate of new onset seizures after COVID vaccination, choosing the best oral antibiotic for mild to moderate CAP, and a trail of melatonin for delirium in older, hospitalized adults
2024-08-1530 minPrimary Care Update
Primary Care UpdateEpisode 160: prostate meds and dementia, umbilical hernias, mortality for infections, and AF detectionThis week, Kate, Mark, Henry and Gary tackle the association between prostate medications and lower dementia risk, the natural history of umbilical hernias in children, differential mortality for flu, RSV and COVID, and what to do about device-detected atrial fibrillation.
2024-08-0526 minPrimary Care Update
Primary Care UpdateEpisode 159: DAPT duration, starting contraception, krill oil for OA, and misdiagnosis of CAPThis week, join Kate, Henry, Gary and Mark as they discuss same-day start contraception, krill oil for adults with knee DJD, misdiagnosis of community-acquired pneumonia, and ticagrelor + placebo VS ticagrelor + ASA after PCI. Plus some book recommendations: Whalefall, The Demon of Unrest, and the Commissario Brunetti novels by Donna Leon
2024-07-1729 minPrimary Care Update
Primary Care UpdateEpisode 158: dequalinium for BV, mammography, weight loss drugs, and tirzepatide for OSAHappy 4th of July! This week Kate, Gary, Henry and Mark celebrate by talking about dequalinium for bacterial vaginosis, the comparative effectiveness of weight loss drugs, the new USPSTF mammography recommendation, and tirzepatide for adults with sleep apnea.
2024-07-0428 minPrimary Care Update
Primary Care UpdateEpisode 157: Bleeding risk with AF, treating minor ischemic stroke, and beta-blockers after AMIIt's cardiovascular day at Primary Care Update as Kate, Mark and Henry discuss bleeding risk with diltiazem in treatment for atrial fibrillation, whether alteplase improves outcomes in patients with minor ischemic stroke, and whether to continue beta-blockers long-term after acute MI with preserved ejection fraction.
2024-06-1927 minPrimary Care Update
Primary Care UpdateEpisode 156: APAP in pregnancy, AI for AOM, current use of Paxlovid, and CGM for T2DMThis week, Kate, Gary, Mark and Henry discuss 4 new studies that answer some important questions: Does acetaminophen in pregnancy and neurodevelopmental outcomes in offspring? Can AI accurately diagnose otitis media in children? Is nirmatrelvir-ritonavir (Paxlovid) still an effective treatment for outpatients with mild to moderate COVID? And finally, what are the benefits and harms of continuous glucose monitoring in patients with type 2 diabetes.
2024-06-0535 minPrimary Care Update
Primary Care UpdateEpisode 155: wrist imaging, opioids post-op, rate vs rhythm control, and updated Cologuard,This week, Kate, Gary, Henry and Mark discuss 4 new studies: a decision support tool for imaging wrist injuries, how many opioids should be dispensed after ACL reconstruction, an updated fecal DNA + FIT test for colon cancer screening, and rate vs. rhythm control and the risk of dementia/cognitive decline. And a quiz about...cicadas! Bzzzz. 
2024-05-2231 minPrimary Care Update
Primary Care UpdateEpisode 154: triptans and CV risk, urate levels and flares, tests for acute diverticulitis, and APOE4Quite a diversity of topics this week, as Gary, Henry, Kate and Mark talk about: CV risk with triptans, baseline urate levels and risk of acute flairs in adults with gout, primary care feasible tests for acute diverticulitis, and how APOE4 homozygosity represents a distinct genetic form of Alzheimer’s disease.
2024-05-0830 minPrimary Care Update
Primary Care UpdateEpisode 153: gabapentinoids and COPD, shoulder dislocations, and older Alzheimer's drugsThis week, Mark is taking a break so Kate, Henry and Gary will discuss gabapentinoids and the risk of severe COPD, rehab after an initial anterior shoulder dislocation, and cognitive enhancers for patients with Alzheimer’s dementia 
2024-04-2430 minPrimary Care Update
Primary Care UpdateEpisode 152: SGLT2's for heart failure, bariatric surgery outcomes, UTI in kids, and lung screening outcomes.Join Kate, Gary, Mark and Henry (who went to the eclipse!) as they discuss SGLT2 inhibitors for older adults and frail adults with heart failure, the long term outcomes of bariatric surgery in adults with T2DM, the best duration of antibiotics for febrile UTI in kids, and real world outcomes of lung cancer screening.
2024-04-1029 minPrimary Care Update
Primary Care UpdateEpisode 151: SSRIs and mania, oseltamivir, exercise and BP, and HPV vaccine preventing cancer.Join us today as Gary, Kate, Mark and Henry discuss risks of SSRIs provoking mania in adolescents, real world effectiveness of HPV vaccination for preventing cervical cancer, whether tamiflu reduces hospitalization in adults with flu, and the effects of exercise on BP.
2024-03-2530 minPrimary Care Update
Primary Care UpdateEpisode 150: EXXUA for depression, ubrogepant for migraine, PCI for stable angina, and a simple way to communicationsThis week, Gary, Kate, Henry and Mark discuss a newly approved medication for major depression in adults, initiation of abortive therapy using ubrogepant during migraine prodrome, the value of PCI for patients with stable angina, and a simple intervention to improve communication with hospitalized patients. And a quiz!
2024-03-1130 minPrimary Care Update
Primary Care UpdateEpisode 149: afib risk scores, tai chi and cognition, flu vax, and managing gallstonesThis week join us as Kate, Mark, Henry and Gary discuss clinical prediction tool for patients using DOACs for atrial fibrillation, the benefits of cognitively enhanced tai chi, whether high dose recombinant flu vaccine is useful in adults 50-64, and watching patients with symptomatic gallstone disease. 
2024-02-2632 minPrimary Care Update
Primary Care UpdateEpisode 148: meds for alcohol withdrawal, opioids and stimulants, and treating agitation in ADThis week, Kate, Henry and Mark discuss pharmacotherapy for alcohol use disorder, using opioids in adults with cancer pain who also use non-medical stimulants, and brexpiprazole for agitation in patients with Alzheimer's dementia.
2024-02-1323 minPrimary Care Update
Primary Care UpdateEpisode 147: TENS for post-op pain, Alzheimer's meds, and delivering bad newsJoin Kate, Mark, Henry and Gary as they talk about: TENS for pain after cesarean delivery, cholinesterase inhibitors and risk of falls, a meta-analysis of the new Alzheimer’s drugs, and telephone delivery of bad news
2024-01-3032 minPrimary Care Update
Primary Care UpdateEpisode 146: nasal suction for infants, amitriptyline for IBS, aspirin to prevent CRC, and talking about hard thingsThis week, join Henry, Kate, Gary and Mark as they discuss 4 great studies: home suction devices for infants with bronchiolitis, amitriptyline for adults with irritable bowel, high-dose aspirin for preventing colorectal cancer, and communicating about serious illness and end of life.
2024-01-1731 minPrimary Care Update
Primary Care UpdateEpisode 145: DAPT for dementia, BP control post-stroke, managing CHD, and probiotics for IBSThis week, Kate, Henry, Mark and Gary discuss antiplatelet medications to prevent dementia, post-stroke blood pressure control, the latest guideline for managing patients with chronic cardiac disease, and probiotics for patients with irritable bowel syndrome.
2024-01-0336 minPrimary Care Update
Primary Care UpdateEpisode 144: cellulitis prognosis, chronic migraine tx, long COVID tx, and drugs for lipidsThis week Kate, Mark, Henry and Gary talk about how long it takes for lower extremity cellulitis to improve, how long it takes for CGRP monoclonal antibodies to take effect in adults with chronic migraine, whether CBT is effective for fatigue in patients with long COVID, and outcome data for various lipid lowering therapies. Plus a painful quiz, and Gary learns what an umbrella review is!
2023-12-2230 minPrimary Care Update
Primary Care UpdateEpisode 143: sponges for acne, renal colic, breast CA overdiagnosis, BP cuff sizeThis week, Kate, Mark, Gary and Henry will discuss a possible new agent for acne, analgesia in adults with renal colic, breast cancer overdiagnosis in older women, and the importance of BP cuff size. Plus a Dickensian quiz.
2023-12-0526 minPrimary Care Update
Primary Care UpdateEpisode 142: Tdap in pregnancy, atogepant for migraine, POCUS for SBO and gastroparesisThis week, join Kate, Mark, Henry and Gary (from his carport) as they discuss third trimester Tdap for prevention of infant pertussis, atogepant for preventing migraines, POCUS for diagnosing small bowel obstruction, and whether any medications work for treating gastroparesis
2023-11-2230 minPrimary Care Update
Primary Care UpdateEpisode 141: an app to reduce drinking, e-cigs to quit smoking, and does ADHD lead to substance useThis week, we give Henry the day off, leaving Kate, Mark and Gary to discuss a new app to reduce unhealthy alcohol use, whether e-cigarettes can help you quit smoking, and whether taking stimulant meds for ADHD increases the risk of substance use down the road. And the quiz, and a book recommendation ("A Voyage for Madmen").
2023-11-0824 minPrimary Care Update
Primary Care UpdateEpisode 140: Mg+ for CP, amox challenge, ACP guidelines, and carotid surgeryThis week Kate, Mark, Gary and Henry discuss magnesium to prevent cerebral palsy, amoxicillin challenge in the primary care clinic for suspectec PCN non-allergy, new ACP guidance on colorectal cancer screening, and surgery for carotid disease.
2023-10-2430 minPrimary Care Update
Primary Care UpdateEpisode 139: U=U, tetracyclines and teeth staining, metformin to prevent long COVID and the best med for onychomycosisThis week, Kate, Mark, Gary and Henry discuss viral loads and risk of HIV transmission, tetracyclines and dental staining in kids, metformin to prevent long COVID in obese and overweight adults, and the effectiveness of terbinafine pulse therapy for ugly toenails
2023-10-1027 minPrimary Care Update
Primary Care UpdateEpisode 138: Deprescribing, meds for neuropsych symptoms in dementia, and lowering BP too muchWhile Mark is biking, Kate, Henry and Gary talk about a deprescribing intervention for older adults in the hospital, medications for managing neuropsychiatric symptoms in adults with dementia, and harms associated with aggressive BP lowering in hospitalized older adults.
2023-09-3030 minPrimary Care Update
Primary Care UpdateEpisode 137: amox/mono, hearing aids, stem cells for knee OA, and preventing T2DMThis week, Kate, Mark, Henry and Gary talk about whether amoxicillin really causes a rash in kids with mono, whether hearing aids improve cognition in the elderly, stem cell injections and knee OA, and nonpharmacologic approaches to preventing type 2 DM.
2023-09-1829 minPrimary Care Update
Primary Care UpdateEpisode 136: Beers, testosterone harms, opioids for back and neck pain, and SDOHThis week, join Mark, Kate, Henry and Gary as they discuss screening for social determinants of health, the updated Beers List of naughty medications, the value of opioids for acute back and neck pain, and testosterone and adverse events.
2023-08-2934 minPrimary Care Update
Primary Care UpdateEpisode 135: osteoporosis treatment, evolocumab, mifepristone for adenomyosis, and ambulatory BPThis week, Kate, Gary, Mark and Henry discuss treatments for osteoporosis in post-menopausal women, the effect of adding evolocumab to a statin - a reanalysis of the FOURIER trial, using mifepristone for painful adenomyosis, and real world data comparing 24-hour ambulatory BP with clinic readings.
2023-08-1632 minPrimary Care Update
Primary Care UpdatePrimary Care Update Episode 134This week, Kate, Gary, Henry and Mark discuss some fun throwbacks to 2003, the new first line medications for treating T2DM, whether you can take a diuretic at bedtime, and how to manage perioperative antihypertensive medications. And a quiz. Get CME credit at iafp.com just for listening, go to their education Web page.
2023-08-0228 minPrimary Care Update
Primary Care UpdateEpisode 133: bilirubin in infants, rest after concussion, child abuse, and why words matterThis week, join Kate, Henry, Gary and Mark as they discuss point of care bilirubin tests for neonatal jaundice, guideline for evaluating children in close contact with abused children, early return to activity after concussion, and terminology preferences by patients being treated for substance use disorder.
2023-07-1925 minPrimary Care Update
Primary Care UpdateEpisode 132: new drug for hot flushes, screening for autism, and steroids for pneumoniaThis week, Kate, Henry and Mark discuss a new drug therapy for vasomotor symptoms of menopause, the accuracy of the M-CHAT tool for autism, and the value of steroids for severe community-acquired pneumonia. And Henry tells a joke about hot air balloons. And the quiz.
2023-07-0328 minPrimary Care Update
Primary Care UpdateEpisode 131: non-STEMI management in frail elderly, diagnosing secondary HTN in kids, and RSV vaccine for pregnant womenThis week, while Gary tries to learn French in of all places France, Kate, Mark and Henry discuss management of non-STEMI in frail older adults, identifying children with secondary hypertension, and RSV vaccination in pregnant women
2023-06-2125 minPrimary Care Update
Primary Care UpdateEpisode 130: bempedoic acid, polypills and dementia, prophylaxis for STIs, and interpreting asymptomatic CADThis week Kate, Gary, Henry and Mark talk about bempedoic acid for the prevention of ASCVD, the polypill and cognitive decline in the elderly, post-exposure prophylaxis in persons at high risk of STIs, asymptomatic CAD and subsequent AMI risk. And do you know how long ankle arthroplasties last?
2023-06-1334 minPrimary Care Update
Primary Care UpdateEpisode 128: BP targets, treatment resistant depression, angry and disruptive patients, and putting infants to bedThis week our intrepid team of primary care physicians (Kate Rowland, Henry Barry, Gary Ferenchick and Mark Ebell) discuss treatment of resistant depression in older adults, recognizing and managing angry and disruptive patients, the best way to settle a cranky infant, and the AAFP 2022 Guideline on BP targets in adults with hypertension.
2023-05-1030 minPrimary Care Update
Primary Care UpdateEpisode 127: LDL targets, genicular nerve blocks, adding cytology to HPV, and HCTZ to prevent stonesThis week, Henry, Kate, Gary and Mark discuss: treating to LDL target or intensity-based statin therapy for adults with CAD, genicular nerve blocks for pain relief in adults with DJD, the value of adding cytology to HPV for cervical cancer screening, and HCTZ for preventing kidney stone recurrence 
2023-05-0226 minPrimary Care Update
Primary Care UpdateEpisode 126: screening for genital herpes, semaglutide for obesity, ACG guideline on lower GI bleed, and whether invasive management is helpful for stable CADThis week, Gary, Kate, Henry and Mark discuss 2 new studies and 2 new guidelines: screening for genital herpes infections from the USPSTF, semaglutide injections in obese adolescents, ACG guidelines for acute lower GI bleeding, and invasive vs. noninvasive management of patients with stable CAD. And Henry manages to not talk about baseball!
2023-04-1229 minPrimary Care Update
Primary Care UpdateEpisode 125: reducing seizure frequency, antidepressants for pain, and periop anticoagulationKate is at the Cubs opener today, so you'll have to settle for Mark, Gary and Henry as they discuss reducing seizures in young kids, the best antidepressants for managing pain, and new ACCP guidelines for peri-operative management of anticoagulation and antiplatelet agents.
2023-03-3126 minPrimary Care Update
Primary Care UpdateEpisode 124: etonogestrel and lactogensis, celiac guidelines, FODMAPS for IBS, and a new CV drugThis week, join Kate, Henry, Gary and Mark as they discuss: immediate insertion of etonogestrel contraception and lactogenesis, ACG Guideline for managing patients with celiac disease, FODMAPS diet for irritable bowel, and a new way to lower cholesterol and reduce CV events.  
2023-03-2033 minPrimary Care Update
Primary Care UpdateEpisode 123: mindfulness, PRP for Achilles rupture, lecanab for Alzheimer's, and VTE prophylaxis post-fractureThis week, Kate, Gary, Henry and Mark discuss mindfulness based stress reduction for anxiety, platelet rich plasma for Achilles tendon ruptures, lecanamab for Alzheimer’s, and VTE prevention after fracture. Is aspirin sufficient?
2023-03-0125 minPrimary Care Update
Primary Care UpdateEpisode 122: predicing dementia, incentives to quit smoking, HP eradication for dyspepsia, and comparison of diabetes medsJoin Kate, Mark, Gary and Henry as they discuss whether we should (or can) use biomarkers to predict mild cognitive impairment or dementia, financial incentives to promote smoking cessation, the efficacy of HP eradication for functional dyspepsia, and results of the glycemic control arm of the GRADE Trial.
2023-02-1532 minPrimary Care Update
Primary Care UpdateEpisode 121: vitamin C for sepsis, probiotics for halitosis, and dyspepsia evaluationThis week, Kate, Henry and Mark discuss vitamin C for sepsis, probiotics for treating halitosis, and new UK guidelines for evaluation of dyspepsia. Plus a quiz: how much time do we primary care docs spend every day delivering preventive services?
2023-02-0124 minPrimary Care Update
Primary Care UpdateEpisode 120: sleepy time for kids, crenezumab for Alzheimers, prognosis after TKA, and intermittent fastingJoin us this week as Kate, Henry, Gary and Mark discuss: nonpharmacologic sleep interventions in children, crenezumab for treating patients with early Alzheimers, prognosis after knee replacement, and time restricted eating (“intermittent fasting”) for weight loss. Henry and Gary are oxygen deprived and recording in Big Sky, teaching a CME course. You can join all four of us on March 3 and 4 in Scottsdale, AZ for 16 hours of content at the Arizona Academy of Family Physicians annual spring course. Click here to learn more and register.
2023-01-1832 minPrimary Care Update
Primary Care UpdateEpisode 119: insomnia treatment, when to take HTN meds, colonoscopy effectiveness, and chlorthalidone vs HCTZAn action packed episode with some truly landmark studies to discuss. Join Kate, Henry, Gary and Mark as they discuss drug treatment of insomnia, when to take your anti-hypertensive meds, whether colonoscopy is effectiveness, and chlorthalidone vs HCTZ. 
2023-01-0432 minPrimary Care Update
Primary Care UpdateEpisode 118: hyperbilirubinemia, diabetic neuropathy, acute heart failure, and screening for CVDThis week, Kate, Gary, Henry and Mark discuss a new guideline for managing jaundice in babies, treating painful diabetic peripheral neuropathy, acetazolamide for patients hospitalized with CHF, and screening for CVD in older men.
2022-12-1027 minPrimary Care Update
Primary Care UpdateEpisode 117: the plague, treatment of prediabetes, asymptomatic bacteriuria, and the value of pyuriaThis week, Mark, Kate, Henry and Gary discuss black Friday, black Death; long term outcomes of managing patients with impaired glucose tolerance or "pre-diabetes" (Henry hates that term); treating asymptomatic bacteriuria in nursing home residents; and the significance of microscopic pyuria in asymptomatic patients.
2022-11-2730 minPrimary Care Update
Primary Care UpdateEpisode 116: Polypills, yoga for migraine, best 2nd drug for DM, and Paxlovid for omicronGary, Kate, Henry and Mark discuss 4 POEMs: polypills for secondary prevention of cardiovascular disease, yoga for migraines, the best 2nd drug for type 2 DM, and clinical outcomes with Paxlovid in the omicron wave.  Do check out Essential Evidence Plus if you want all of the POEMs each month and a great primary care reference.
2022-11-0932 minPrimary Care Update
Primary Care UpdateEpisode 115: bisphosphonates and mortality, COVID rebound, and 2 IBS treatmentsThis week, join Mark, Kate, Gary and Henry as they discuss 4 studies: mortality reduction from the treatment of osteoporosis, hypnosis for patients with IBS, COVID rebound syndrome, and low FODMAP diets in patients with IBS.
2022-10-2930 minPrimary Care Update
Primary Care UpdateEpisode 113: POC respiratory panels, fever in adults, and CV benefits of SGLT-2'sToday Kate, Gary and Henry talk about point of care respiratory panels for children, outcomes of controlling fever in adults, and SGLT2 inhibitors and heart failure. Mark is enjoying Murphy's in Cork but still managed to do the post-production.
2022-09-2827 minPrimary Care Update
Primary Care UpdateEpisode 112: buckle fractures, tirzepatide for obesity, and stroke risk with severe carotid stenosisThis week, Henry, Gary and Mark discuss: managing children with torus (buckle) fractures of the distal radius, tirzepatide for treating obesity in adults without T2DM, and stroke risk in patients with asymptomatic severe carotid artery stenosis. Kate couldn't join us this week, but check out her thoughtful essay in the journal Family Medicine 
2022-09-1424 minPrimary Care Update
Primary Care UpdateEpisode 110: pharmacogenomics, functional abdominal pain in kids, vitamin D and fractures, and a T2DM guidelineThis episode, Henry, Kate, Mark and their colleague Gary Ferenchick from MSU discuss: pharmacogenomic-guided antidepressant therapy, non-drug interventions for children with functional abdominal pain, Vitamin D and fracture risk in the elderly, and NICE guideline for persons with T2DM.
2022-09-0328 minPrimary Care Update
Primary Care UpdateEpisode 109: motivational interviewing for weight loss, urate lowering in gout, and screening for anal cancer.This week Kate, Henry and Mark discuss motivational interviewing for weight loss, intensive vs standard urate lowering in persons with gout, and screening high risk persons for anal cancer.
2022-08-1722 minPrimary Care Update
Primary Care UpdateEpisode 108: LDL and mortality, cost-effectiveness of Alzheimer drugs, and surgery for ortho problemsThis week, Kate, Henry and Mark discuss how much statins lower mortality, the cost-effectiveness of the new crop of Alzheimer's drugs, and whether surgery is helpful for a range of orthopedic conditions. 
2022-08-0321 minPrimary Care Update
Primary Care UpdateEpisode 107: TENS for renal colic, secondary HTN in kids, and evaluating chest painThis week, Kate, Mark and Henry will discuss secondary hypertension in children, TENS for persons with renal colic, and CTA vs angiography in persons with suspected stable CAD.
2022-07-2021 minPrimary Care Update
Primary Care UpdateEpisode 106: hMKPX (OK, monkeypox), screening for afib, and aducanumab for Alzheimer dementiaJohn has the week off, so Kate, Mark and Henry plow forward rudderless and talk about monkeypox (sorry, WHO, we're not calling it hMKPX, buy a vowel), screening for atrial fibrillation, and our new candidate for worst drug ever: aducanumab for Alzheimer dementia.
2022-07-0624 minPrimary Care Update
Primary Care UpdateEpisode 105: coronary calcium CT, what happens to prediabetics, an RCT of ketamine, and 1 vs 2 antidepressantsThis week, Kate, Mark, Henry and John discuss the added value of coronary calcium scores, the natural history of prediabetes in older adults, using ketamine in suicidal persons, and whether antidepressant combination or monotherapy is better in severe or refractory depression. 
2022-06-2227 minPrimary Care Update
Primary Care UpdateEpisode 104: stress urinary incontinence, thyroid meds, Achilles tendon rupture, and HEPA for COPDKate, John, Henry and Mark (he set his alarm this time) are back to talk about a new treatment for female stress urinary incontinence, air cleaners for preventing COPD exacerbations in smokers, surgery vs non-operative management of Achilles tendon rupture, and whether switching among levothyroxine generics is a problem.
2022-06-0827 minPrimary Care Update
Primary Care UpdateEpisode 103: rosacea treatment, Dr. Google, and vitamin D and COVIDThis week Mark slept in, so Kate, John and Henry talk about British guidelines for treatment of rosacea, what to do when Dr. Google comes to the office, and Vitamin D and COVID.
2022-05-2629 minPrimary Care Update
Primary Care UpdateEpisode 102: Prevention of preterm delivery, statins during pregnancy, and aromatherapy for postmenopausal symptomsThis week, Kate leads us on a special Mother's Day edition focused on women's health. Topics discussed by Kate, John and Henry (Mark is in Würzburg busily pontificating) include prevention of preterm delivery, statins during pregnancy, and aromatherapy for postmenopausal symptoms.
2022-05-1025 minPrimary Care Update
Primary Care UpdateEpisode 101: new VTE guidelines, weight loss drugs, and increased CV risk post-COVIDThis week Kate, Henry and Mark discuss updated guideline recommendations for treatment of VTE, weight loss drugs, and the increased risk of cardiovascular events following COVID-19 infection. John has the week off.
2022-04-2926 minPrimary Care Update
Primary Care UpdateEpisode 100: Best of the best of the best!This week, Kate, Mark, Henry and John pick their 4 favorite POEMs from the first 99 episodes. We'll dig into aspirin, beer before wine or vice versa, chronotherapy for hypertension, and asthma diagnosis. And thanks for being our audience for 100 episodes! Keep listening, and spread the word to friends and colleagues.
2022-04-1133 minPrimary Care Update
Primary Care UpdateEpisode 99: NSAIDS for back pain, masks in schools, fluoride, and antipsychoticsJoin family physicians Kate Rowland, Mark Ebell and John Hickner this week as they discuss the best NSAID for acute low back pain, a study on masks in schools to reduce COVID incidence, antipsychotics, and the benefits of fluoride varnish and supplements in kids. 
2022-03-1622 minPrimary Care Update
Primary Care UpdateEpisode 98: COVID, pain management without opioids, irritable bowel, and communicating riskA diverse set of POEMs from Kate, John, Henry and Mark: CDC COVID mitigation and vaccination updates, non-opioid post-op pain management, a guideline for managing persons with IBS, and the challenges of communicating risk with words
2022-03-0430 minPrimary Care Update
Primary Care UpdateEpisode 96: medication safety, midodrine for syncope, empagliflozin for heart failure, and peppermint oil for IBSThis week Kate, Henry, Mark and John are all over the map, with 4 new studies on the safety of Janus Kinase inhibitors, midodrine for recurrent vasovagal syncope, empagliflozin for heart failure (not DM) and peppermint oil for irritable bowel syndrome. 
2022-02-0225 minPrimary Care Update
Primary Care UpdateEpisode 95: measuring temps, implantable monitors, procalcitonin in primary care, and HPV based cancer screeningThis week Kate, Mark, Henry and John talk about measuring temps in kids, implantable monitors to diagnose afib, procalcitonin in primary care, and HPV based cervical cancer screening
2022-01-2025 minPrimary Care Update
Primary Care UpdateEpisode 94: overcoming vaccine hesitancy, fluvoxamine and Paxlovid for COVID-19, and tighter BP control in eldersThis week family physicians Kate, John, Henry and Mark discuss best practices for vaccine uptake, fluvoxamine for outpatients with COVID, Paxlovid for outpatients with COVID, and the benefits and harms of lowering BP in older persons.
2022-01-0531 minPrimary Care Update
Primary Care UpdateEpisode 93: holiday death rates, ear wax, amoxicillin for kids, and vaccines and the omicron variantThis week, family physicians Kate, John, Henry and Mark will discuss whether mortality really increases over the holidays, the best way to prep patients for ear wax removal, whether high dose amoxicillin is effective for kids with lower respiratory infection, and how effective vaccines are against omicron. Plus a special Christmas quiz!
2021-12-2226 minPrimary Care Update
Primary Care UpdateEpisode 91: iron for anemic infants, IL-6 antagonists and inhaled steroids for COVID, and PRP for Achilles tendinopathyThis week Kate, Henry, John and Mark discuss whether iron supplementation provides real benefits for anemic infants, IL6 antagonists for COVID, inhaled corticosteroids for COVID, and platelet rich plasma for Achilles tendinopathy. 
2021-11-2427 minPrimary Care Update
Primary Care UpdateEpisode 90: music therapy, lung CA screening, VTE prophylaxis, and a pain guidelineThis week, Kate, John, Mark and Henry discuss music to improve sleep and cognition in older adults, lung cancer screening in an organized health system, a comparison of 2 agents for VTE prophylaxis after total knee arthroplasty, and a new pain guideline with a surprising recommendation.
2021-11-2032 minPrimary Care Update
Primary Care UpdateEpisode 89: pumpkin seeds, placebo for post-op pain, muscle relaxants, and depression screeningThis week, join Kate, John, Henry and Mark for a discussion of pumpkin seed oil for BPH symptoms, open label placebo for post-op pain, muscle relaxants for low back pain, and the implications of universal depression screening. 
2021-10-2826 minPrimary Care Update
Primary Care UpdateEpisode 88: influenza, stroke prevention, a novel telemedicine use, and T2DM overtreatmentJoin Kate, Henry, John and Mark as they discuss antivirals in children hospitalized with influenza, DAPT for secondary stroke prevention, the safety and effectiveness of no-test medical abortions, and harms of overtreating older persons with T2DM.
2021-10-1733 minPrimary Care Update
Primary Care UpdateEpisode 87: COVID boosters, ivermectin, and pregnancy outcomes with COVID infectionKate, Mark, John and Henry discuss the value of three doses of mRNA vaccine for immunocompromised people, Ivermectin for treating persons with COVID-19, the benefits of boosters based on Israeli data, and pregnancy outcomes of women with COVID-19 infection. 
2021-09-3024 minPrimary Care Update
Primary Care UpdateEpisode 86: dexamethasone post-op, topical terbinafine for toenails, thromboprophylaxis, and vaccine adverse eventsThis week Kate, Mark, Henry and John (he's back!) discuss dexamethasone after major non-cardiac surgery, topical terbinafine for onychomycosis, thromboprophylaxis during knee replacement, and mRNA COVID vaccine adverse events
2021-09-1529 minPrimary Care Update
Primary Care UpdateEpisode 85: aspirin and antidepressant doses, how low to go with BP, and eye drops for migraineThis week, Kate, Henry and Mark discuss comparative efficacy of aspirin doses, blood pressure lowering and health outcomes, dosing of antidepressants, timolol eye drops for acute migraine treatment
2021-09-0329 minPrimary Care Update
Primary Care UpdateEpisode 84: adenotonsillectomy in kids with OSA, DAPT vs ASA for stroke prevention, and ovarian cancer screeningThis week Kate, Henry and Mark give John the week off and discuss outcomes after adenotonsillectomy in children with OSA, the effectiveness and safety of DAPT vs ASA for secondary stroke prevention, and the final results of the largest trial of screening for ovarian cancer using CA-125 and ultrasound.
2021-08-1928 minPrimary Care Update
Primary Care UpdateEpisode 83: TIA risk score, US for frractures, CDC delta variant report, and harms of MRIThis week, Kate, Henry, Mark and John will discuss the Canadian TIA score, ultrasound for diagnosing upper extremity fractures in children, a summary of the leaked CDC report on breakthrough cases and the delta variant, and how MRI reports can cause harm
2021-08-0328 minPrimary Care Update
Primary Care UpdateEpisode 82: PCR stool tests in kids, duration of antibiotics for CAP in kids, and an UGI bleed guidelineThis week, we give John the episode off, so Kate, Mark and Henry will discuss rapid stool tests in children with community acquired diarrhea, a guideline for managing patients with acute UGI bleeding, and the best duration of antibiotics for ambulatory kids with community-acquired pneumonia
2021-07-2325 minPrimary Care Update
Primary Care UpdateEpisode 80: Cannabis, PRP for plantar fasciitis, epidural steroids, and COVID mortality and raceThis week, Kate, Mark, John and henry will discuss cannabis use in patients with rheumatologic disorders, platelet-rich plasma injections for persons with plantar fasciitis, epidural steroid injections for sciatica, and COVID mortality and race.
2021-06-2429 minPrimary Care Update
Primary Care UpdateEpisode 78: PCN allergy, US guided injections, IBS, and prediabetes prognosisThis week, Kate, Mark, Henry and John will discuss penicillin allergy, US-guided steroid injections, psychological therapies for patients with IBS and the natural history of “prediabetes”. Plus the quiz from Kate.
2021-05-2726 minPrimary Care Update
Primary Care UpdateEpisode 77: deprescribing antibiotics, BP screening recommendations, vit D and fish oil to prevent AF, and steroids for wheeze preschoolers.This week, Kate, Mark, John and Henry discuss a proven strategy to decrease antibiotic prescribing, learn about updated USPSTF recommendations for blood pressure screening, whether vitamin D and fish oil for prevent A fib, and the value of oral steroids for wheezy preschoolers age 2 to 5.
2021-05-1426 minPrimary Care Update
Primary Care UpdateEpisode 75: Duration of symptoms with mild and severe COVID, and true rate of vaccine anaphylaxisThis week, Mark reports the first study looking at the duration of symptoms with mild COVID in healthcare workers (more than you think) compared to those without COVID. Then Henry looks at the same thing in hospitalized COVID patients compared to those with other respiratory infections in the US and UK, and John tells us the true rate of anaphylaxis with vaccines.
2021-04-1526 minPrimary Care Update
Primary Care UpdateEpisode 72: Flozins and tides, new med for migraine, and antidepressants for back pain and DJDThis week, Mark, Henry and guest POET Kate Rowland from Rush Medical College discuss: newer agents to treat diabetes,  a new medication for migraine prevention, and antidepressants for pain in patients with back pain or DJD.
2021-03-0426 minPrimary Care Update
Primary Care UpdateEpisode 60: DAPT after stroke, gout, and HRT after 20 yearsThis week John, Henry and Mark discuss dual antiplatelet therapy after stroke, updated recommendations for management of gout, and long-term follow up of hormone replacement for post menopausal women.
2020-09-1824 minPrimary Care Update
Primary Care UpdateEpisode 28: 2 hour MI rule out, tramadol safety, and steroids for pneumoniaThis week, guest host Dr. Dave Slawson joins Henry and Mark. We discuss rapid (< >
2019-10-0323 minPrimary Care Update
Primary Care UpdatePrimary Care Update Episode 23This week, John, Henry and Mark talk about adding ultrasound to mammography for screening (https://www.ncbi.nlm.nih.gov/pubmed/30882843), routine labs for patients on an antifungal (https://www.ncbi.nlm.nih.gov/pubmed/30347032), and podiatry interventions to prevent falls (https://www.ncbi.nlm.nih.gov/pubmed/30615052).
2019-07-2324 minPrimary Care Update
Primary Care UpdatePrimary Care Update Episode 19This week John, Henry and Mark discuss interpretation of FIT tests for CRC screening (https://www.ncbi.nlm.nih.gov/pubmed/30802902); diagnosis of appendicitis (https://www.ncbi.nlm.nih.gov/pubmed/30017693); and treatment of neonatal abstinence syndrome (https://www.ncbi.nlm.nih.gov/pubmed/30667476). Plus, a quiz about metformin.
2019-05-2825 minPrimary Care Update
Primary Care UpdatePrimary Care Update Episode 18Today Mark, John and Henry talk about: how to rule out (and rule in) pneumonia (https://www.ncbi.nlm.nih.gov/pubmed/30850460); an RCT of e-cigarettes for smoking cessation (https://www.ncbi.nlm.nih.gov/pubmed/30699054); and non-drug treatments for IBS (https://www.ncbi.nlm.nih.gov/pubmed/30177784). 
2019-05-1420 minPrimary Care Update
Primary Care UpdatePrimary Care Update Episode 17This week, Henry, Mark and John discuss: statins for primary prevention in the elderly (https://www.ncbi.nlm.nih.gov/pubmed/30712900); beer before wine or vice versa (https://www.ncbi.nlm.nih.gov/pubmed/30753321); and the impact on control on school performance in kids with T1DM (https://www.ncbi.nlm.nih.gov/pubmed/30721295). Plus a beer themed quiz.
2019-04-2922 minPrimary Care Update
Primary Care UpdatePrimary Care Update Episode 14Today we talk about stem cell injections for osteoarthritis (https://www.ncbi.nlm.nih.gov/pubmed/29099618), a rant about mortality outcomes in cancer screening from Mark, omega-3 oils for primary prevention (https://www.ncbi.nlm.nih.gov/pubmed/30415637), and testosterone for depression in men (https://www.ncbi.nlm.nih.gov/pubmed/30427999).
2019-03-1926 minPrimary Care Update
Primary Care UpdatePrimary Care Update: Episode 4Mark, John and Henry talk about tamsulosin for helping stones pass (but not all of them), how aspirin and esomoprazole (at the right dose) can reduce mortality in Barrett's esophagus, whether to do HPV only or co-testing in women 30-65 years, and the safety (and effectiveness) of lorcaserin for weight loss.
2018-10-2326 minPrimary Care Update
Primary Care UpdatePrimary Care Update: Episode 3Mark, John and Henry discuss the new aspiring studies (does it really prevent heart disease), a positive (!) vitamin D trial, and whether procalcitonin can help us avoid antibiotics for patients with lower respiratory infection. Plus, the quiz, and John nerds out about vitamin D. In a good way.
2018-10-0829 min