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Martin Borch Jensen

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TechNation Radio PodcastTechNation Radio PodcastEpisode 25-04 Reprogramming the FutureOn this week’s Tech Nation, Moira speaks with Dr. Martin Borch Jensen and Dr. Francisco LePort from Gordian Biotechnology, who are working on diseases of aging before they even appear. Then, Tech Nation Health Chief Correspondent, Dr. Daniel Kraft, explains why mobility is the new vital sign. And Erica Dhawan, Author of Digital Body Language, tells us how to navigate the misinterpretations of digital communication.2025-02-0159 minTechNation Radio PodcastTechNation Radio PodcastEpisode 25-04 Reprogramming the FutureOn this week’s Tech Nation, Moira speaks with Dr. Martin Borch Jensen and Dr. Francisco LePort from Gordian Biotechnology, who are working on diseases of aging before they even appear. Then, Tech Nation Health Chief Correspondent, Dr. Daniel Kraft, explains why mobility is the new vital sign. And Erica Dhawan, Author of Digital Body Language, tells us how to navigate the misinterpretations of digital communication.2025-02-0159 minBioTech Nation ... with Dr. Moira GunnBioTech Nation ... with Dr. Moira GunnReprogramming the Future... Dr. Martin Borch Jensen and Dr. Francisco LePort, Gordian BiotechnologyThis week on Biotech Nation, Dr. Martin Borch Jensen and Dr. Francisco LePort from Gordian Biotechnology share a bold new approach to fighting diseases of aging before they take hold. Instead of testing one drug at a time, their technology allows scientists to test hundreds of potential treatments at once, making drug discovery faster and more precise. This could change how we treat conditions like arthritis, heart failure, and fatty liver disease.2025-01-2925 minInner Cosmos with David EaglemanInner Cosmos with David EaglemanEp 81 "How close are we to longevity?"Two certainties are death and taxes; a third is that people will work hard to avoid them both. But why is it so difficult to extend our lifespan? We know how to do it in worms and mice; why is it tricky in humans? Why do so few companies study longevity? What does the near future hold? What would it be like if everyone lived a much longer life? Join Eagleman this week with longevity expert Martin Borch Jensen to discuss the hopes and challenges of longevity science.2024-11-1852 minThe Genetics PodcastThe Genetics PodcastEP 150: Cracking the biological code of aging with Martin Borch Jensen, Co-Founder and Chief Scientific Officer at Gordian Biotechnology0:00 Intro to The Genetics Podcast01:00 Welcome to Martin01:35 How a particularly large Indian meal resulted in a book about intermittent fasting and the biology of ageing05:10 The biological mechanisms behind intermittent fasting, and whether it’s been established to extend life expectancy in humans.10:13 What we know (and what we don’t) about the fundamentals of biological ageing and how it influences drug development15:28 Using trial and error to identify the mechanisms and phenotypes which can improve biological age17:20 How Gordian Biology got its name and how it links to the challenges of biological agei...2024-09-0544 minVitaDAO is a community owned collective funding early stage longevity research, governed by $VITAVitaDAO is a community owned collective funding early stage longevity research, governed by $VITAInsights on Grant-making and Systemic Change: Lessons from Impetus and BeyondInsights on Grant-making and Systemic Change: Lessons from Impetus and Beyond with  Martin Borch Jensen & Lada Nuzhna. Outline:  0:00 What is Impetus and how did it get started? 3:12 Takeaways from running and creating Impetus Grants 5:04 Playbook for starting a grant-making program. 12:29 Common misunderstandings between the private sector and academia about funding. 14:12 The role of academia in publishing negative results 23:18 The most impactful levers for systemic change.2023-02-2349 minA4LI H-SPAN PodcastA4LI H-SPAN PodcastEpisode 5 - Martin Borch JensenThis week, we are joined by Martin Borch Jensen, the co-founder and Chief Science Officer of Gordian Biotechnology.In this episode, we get into how Martin got involved in the longevity movement, as well as his latest research and insights he has picked up on the path to extending healthy human lifespan.2023-02-0746 minRingdal & KristensenRingdal & Kristensen"Din fucking luder": Skoleelev er vært for program om sexismeDer er sexisme i den danske folkeskole. Så klart er budskabet fra Philippa Rosic, som går i 9. klasse på NGG - Nordsjællands Grundskole og Gymnasium.Hun oplever blandt andet, at pigerne i sin klasse får at vide, at de er ludere, eller at de skal gå ud i køkkenet, hvis de fx ikke vil låne drengene en blyant.Vi har givet hende én time til at komme til bunds i problemet om sexisme på hendes skole.Medvirkende: - Martin Krasnik, chefredaktør på Weekendavisen- Emma Bruus Jensen, elev...2022-02-2352 minForesight Institute RadioForesight Institute RadioThe Longevity & Rejuvenation Tree | Karl Pfleger, Greg Fahy, Martin Borch Jensen, Laurence Ion, Jose Luis RiconHow can we reach longevity escape velocity in your lifetime? This is a conversation from Vision Weekend US 2021. Speakers include: Karl Pfleger, AgingBiotech.infoGreg Fahy, Intervene ImmuneMartin Borch Jensen, Gordian Laurence Ion, VitaDAO Jose Luis Ricon, RejuvenomeMusic: I Knew a Guy by Kevin MacLeod is licensed under a Creative Commons Attribution 4.0 license. https://creativecommons.org/licenses/by/4.0/Source: http://incompetech.com/music/royalty-free/index.html?isrc=USUAN1100199Artist: http://incompetech.com/Rema...2022-02-1434 minWhat\'s Next｜科技早知道What's Next｜科技早知道S5E29｜重金押注抗衰老公司，硅谷真的可以做出长生不老药吗？2021 年 9 月 4 日，《麻省理工科技评论》发布报道，称亚马逊创始人 Jeff Bezos 和硅谷著名投资人 Yuri Milner 在近期投资了专注于抗衰方向的生物科技公司 Altos Labs，一家今年四月才成立的抗衰老公司，科学家团队包括 2012 年诺贝尔生理学或医学奖的获得者山中伸弥；截至今年六月，该公司已经吸引了至少 2.7 亿美元的投资。这并非硅谷富豪们第一次入局抗衰领域。 2018 年， Jeff Bezos 和 PayPal 联合创始人 Peter Thiel 共同投资抗衰领域独角兽 Unity Biotechnology；而更早之前，还有谷歌创始人 Larry Page 宣布 10 亿美元投资生物科技公司 Calico，目前 Calico 已经被整合至谷歌母公司 Alphabet Inc。我们似乎可以清晰地看见，在颠覆互联网、物流制造、航空航天等领域之后，硅谷大佬们的下一个目标，正是通过生物工程技术突破人类目前的寿命上限，将长生不老的选择权紧紧握在手里。 本期节目，我们邀请到了同样在抗衰领域被视为明星公司的硅谷新贵 Gordian 的首席科学家 Martin Borch Jensen。他和主播 Diane 一起探讨了硅谷的投资者们都是出于什么原因投资 Altos Labs 等生物科技公司，值得关注技术路径有哪些，投资人应该如何看待生物科技领域的超长投资周期和技术挑战，头部公司可以通过什么途径实现商业回报。 #加入我们# 声动活泼正在招聘「内容研究员」、「业务拓展和合作管理总监/经理」、「声音设计师」、「播客制作实习生」、「内容营销负责人」及「节目制作人」，查看详细讯息请在公号「声动活泼」回复暗号：入场券 。简历接收邮箱📮 hr@shengfm.cn 。 ▼主播 丁教，声动活泼联合创始人 ▼嘉宾 Martin Borch Jensen，Gordian 首席科学家 ▼主要话题 [02:24] 本期节目的亮点总结 [09:03] Gordian 是什么样的生物科技公司？ [10:30] 大牛辈出的巴克研究所在抗衰科研领域是什么样的存在？抗衰领域的生物科技初创公司应该选择在西海岸还是东海岸？ [14:34] 为什么抗衰领域会引来硅谷富豪的投资热潮？ [17:53] Elysium 推出的膳食补充剂 Basis 真的可以抗衰吗？ [19:50] 抗衰的主流技术路径都有哪些？ [27:03] 像 BioViVa 的 CEO 给自己注射抗衰药物的事情常见吗？ [27:57] 除了富豪们的家族信托基金，还有哪些投资机构关注这个赛道？什么时候看见回报？ [30:55] 抗衰公司为什么在二级市场不吃香？临床实验失败有多常见？ [35:30] 如何理解 Gordian 这样的平台型公司的商业模式？谷歌麾下的 Calico 值得期待吗？ [40:58] 抗衰领域在面临哪些挑战？衰老标志物会如何促进抗衰研究的发展？抗衰进程已经走到哪一步了？ [48:30] 有什么人人皆可尝试的长寿小秘诀？ ▼延伸阅读 Meet Altos Labs, Silicon Valley’s latest wild bet on living forever Mutation Doubles Life Span In Worms A month after losing its lead program, Unity Biotechnology cuts 30% of staff in restructuring 雷帕霉素（ Rapamycin, RAPA ）：一种临床使用的免疫抑制剂，常用于肾移植抗排异治疗和肾癌治疗；1994 年发现抑制雷帕霉素靶点（Mechanistic Target of Rapamycin，mTOR）可调控细胞的存活，2009 年被证明可用于肝硬化及肝功能退化、阿尔茨海默症等并重的治疗，现为主流的长寿药之一 靶向清除衰老细胞的药物（ Senolytics ）：尚无正式的中文译名，2015 年在《 Aging Cells 》上首次出现，由 CAR-T 细胞改造为可定向清除衰老细胞的小分子药剂，其中达沙替尼+槲皮素（ Dasatinib plus Quercetin, D+Q ）的联合用药在 2018 年的小鼠实验中被证明可以成功清除衰老细胞，Unity Biotechnology 的 Judith Campisi 设计出 Senolytics 药剂 UBX0101，尚未通过 II 期临床试验 二甲双胍靶向治疗衰老（ Targeting Aging with Metformin，TAME ）：二甲双胍在1922年首次被人工合成，常见于糖尿病治疗和预防，后被发现可用于延缓衰老，抗衰机制包括通过代谢途径激活AMPK（一种蛋白质激酶，可调控能量平衡）、通过抗氧化途径抑制线粒体I型复合体电子传递系统 重编程技术：被认为是逆转衰老的重要手段之一，可通过诱导性多能干细胞（ Induced pluripotent stem cell，iPS ）的技术对细胞进行重新编程，清除细胞的表观遗传记忆并让细胞变得年轻，但也有实验证明该技术可能加速癌症并发 巴克衰老研究所（ Buck Institute for Research on aging ）：非盈利的独立生物医学研究所，1999年成立，是全世界第一个专注于衰老领域的研究所，2018 年与 Insilico、Juvenescence 联合创立 Napa Therapeutics，推进 NAD+ 抗衰药物研发，该研究所也是世界上第一家研究衰老干预过程的研究所，Unity Biotechlogy 的联合创始人 Judith Campisi 目前仍在该所任职 Gordian：抗衰老领域的创新药服务商，2018 年成立，投资方包括 The Longevity Fund、Formic Ventures、谷歌 AI 负责人 Jeff Dean，主要为抗衰领域药企的研发和实验提供测试平台和量化模型，可比公司包括 Genentech、Atomwise Atomwise：AI 医疗公司，通过 AI 进行药物设计并销售相关药品给厂商，并对药物的收入按一定比例收取佣金，类似的公司还有 Exscientia、InSilico Medicine Genentech：中文译名基因泰克，起家于 DNA 重组技术的生物科技公司，1976 年由诺奖获得者 Herbert Boyer 联合风险投资人 Kleiner Perkins 创立，1980 年在纳斯达克上市，代表产品包括 Avastin 抗癌药物，与 Gordian 的商业模式类似，2009 年被瑞士罗氏制药公司以468亿美元的价格收购 Elysium Health：膳食补充剂公司，2014 年成立，科学家顾问团包括神经生理学家 Thomas C. Südhof 等多位诺奖得主，代表产品包括 NAD+ 类保健品 Basis（主要成分为烟酰胺核糖和紫檀芪），该产品未经过FDA的药品审批程序，类似的 NMN 产品在国内也未获得监管的生产批准许可 Altos Labs：专注于干细胞重编程的抗衰生物技术公司，2021 年成立，2021 年诺贝尔生理学或医学奖的获得者山中伸弥和甲基化生理年龄时钟之父 Steve Horvath 均为科学顾问委员会成员，贝佐斯投资标的之一，类似的技术方向还有AgeX等主2021-10-2053 minTranslating AgingTranslating AgingGene therapy screening to discover aging targets (Martin Borch Jensen - Gordian Biotechnology)Gene therapy screening to discover aging targets (Martin Borch Jensen -  Gordian Biotechnology)Gordian Biotechnology is a San Francisco Bay Area biotech company that has created the first in vivo therapeutic screening platform aimed at drug development for complex diseases of aging. Co-founder and Chief Science Officer, Dr. Martin Borch Jensen joins the show today to discuss Gordian’s unique in vivo pooled screening in animals, as well as which indications they are targeting, their strategy to bring drugs to market, and how Gordian is currently tackling the challenges inherent to animal models. Martin also speaks about his...2021-09-1555 minTri226 Triathlon PodcastingTri226 Triathlon PodcastingDM JuelsmindePodcast nr. 25 - Resultater fra ind- og udland samt og race reports fra DM i Juelsminde. Lyt med nеr Martin Jensen fortжller om sin DM- sejr og hans planer for fremtiden og hшr DM-kommentarer fra Watt-Madsen, Borch og Markovic.2009-08-1400 min