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The Healthtech PodcastThe Healthtech Podcast#402 Dr Mustafa Sultan from Anterior: Why The Future of Healthtech Depends on Taking RisksThis week, James is joined by Dr Mustafa Sultan, Clinical AI and Growth Lead at Anterior and host of the Big Picture Medicine podcast. From working as an Emergency Department doctor in the NHS, Mustafa uses his clinical and technological expertise to support Anterior on their mission to build an AI platform that reduces the administrative burden on clinicians. Learn more: https://www.anterior.com/Apply to be a guest: www.thehealthtechpodcast.comSubscribe to Healthtech Pigeon 🐦: www.healthtechpigeon.comGet in touch with James: www.jamessomauroo.com2025-06-251h 09Big Picture MedicineBig Picture Medicine#134 Sean Duffy, Omada Health ($1bn+ Valuation)According to Business Insider, Omada Health has quietly filed its S-1 to prepare for an IPO. Here's how Sean Duffy (CEO & Co-founder) built it. 0:00 Intro 0:17 Signing first customer 1:51 How to have good ideas in healthcare 4:00 Why metabolic health is a hard area to innovate in 5:18 What the MVP product looked like 11:16 Sean's secret tactics 14:55 Operational innovation as a differentiator 20:19 The Omada playbook — is it repeatable? 25:31 What boss moves have you made Sean? 29:37 The difference between good an...2025-01-0135 minBig Picture MedicineBig Picture Medicine#133 A New Radiology Foundation Model ($160M Raised) — Harrison.ai CEO, Dr Aengus TranDr Aengus Tran is the CEO of Harrison.ai — an Australian radiology AI startup who have raised $160M. Harrison.ai just released their radiology foundation model, Harrison.rad.1. And it's really good. 0:00 Intro 2:25 I'm glad I didn't found my startup in the US 4:21 Partnering with a clinical operator is key 7:28 Scrappy stories from the early days 11:17 Where human radiologists outperform AI (zero-shot learning) 17:23 Big bets on the future of radiology 21:18 What happens when GPT-8 arrives? 25:29 Ho...2024-10-2734 minBig Picture MedicineBig Picture Medicine#132 Arcadia CEO ($100M ARR) on How To Sell Enterprise Healthcare — Michael MeucciMichael Meucci (CEO) transformed Arcadia — formerly a mid-sized consultancy into a healthcare platform with $100M of Annual Recurring Revenue. How? Lots of smart moves, including becoming really good at enterprise healthcare selling. Here's how he did it. Links Arcadia: https://arcadia.io/ Dr Mustafa Sultan: https://www.musty.io/ 2024-08-2625 minBig Picture MedicineBig Picture Medicine#131 Scaling Contraceptive App to 2M Users By Daring Not to Be Free (Dr Elina Berglund, CEO Natural Cycles)Dr Elina Berglund is the CEO/Co-founder of Natural Cycles, which she has grown to 2M users. When every other app seemed to be free — she made a brave decision: She charged her users a monthly fee. And it worked... 0:57 - The Birth of Natural Cycles 2:57 - The Decision to Charge from the Start 3:47 - Building Trust Through Pricing 4:23 - From Personal Struggles to Public Solution 5:52 - Creating the Fail-Safe Algorithm 6:32 - Collaboration with CERN Colleagues 7:13 - The Human Body: Complex Beyond Measure 8:37 - The Promise and Challenge of Wearables 10:16 - Understanding User Behavior 11:04...2024-05-2730 minBig Picture MedicineBig Picture Medicine#130 Kaia Health, Raising $125M By Turning $50,000 Elite Pain Rehab into an App (CEO, Konstantin Mehl)Konstantin started Kaia Health after paying $50,000 to cure his back pain at an elite pain rehab centre. It worked. But it seemed stupid. Why did this need to cost $50,000? Kaia Health has since raised $125M and helped 625,000 users. 0:00 The 90 second story 1:22 How did he grow 20% every week? 2:15 Market timing is everything 7:43 We never put pressure on this making any money 10:51 How does an app cure back pain? 14:43 US vs Germany for digital health entrepreneurs 16:40 Go to market...2024-03-2429 minBig Picture MedicineBig Picture Medicine#128 AgeTech: Shopify vs Amazon Model — Birdie CEO, Max ParmentierMax Parmentier is the CEO of Birdie, a Series B AgeTech startup who have raised $52M from the likes of Sofina, Omers Ventures and Index Ventures — and captured 10% of the UK market whilst currently scaling into Europe. 0:00 Intro 2:37 Shopify vs Amazon model in AgeTech 7:26 Product pivots: D2C never wins 11:56 Predictive AI AgeTech 13:58 I pitch an idea to Max 19:34 Lessons building Birdie 24:13 Leaving money on the table for purpose Links Birdie: https://www.birdie.care/ Dr Mu...2023-12-2429 minBig Picture MedicineBig Picture Medicine#127 Gentle Disruption Wins in Healthcare — DrDoctor CEO Tom WhicherTom Wicher is CEO of DrDoctor — who have served over 20M patients and just raised £10M in their recent Series A round. But he spent the first 7 years bootstrapping, and diverged from his colleagues: Opting for the slow and steady gentle disruption path. Why? 0:00 Gentle disruption beats move fast and break things 3:36 Picking a problem in healthcare 5:44 Behavioural change theory 7:52 Stop treating patients like kids 10:30 Systems-level efficiency vs personalisation 13:02 Why don't patients show up for their appointments? 16:02 Overbooking: Learning from airlines 1...2023-12-0333 minBig Picture MedicineBig Picture Medicine#126 Drug Discovery is Becoming More $$$ — Here's Why, And The Startup Fixing It (Lindus Health)Drug discovery is becoming more expensive and producing less results than ever before (Eroom's Law)—why? One of the ballooning costs are clinical trials. Pharma/biotech often outsource their trials to CROs (contract research organisations). But many CROs are incentivised to make trials as bloated and inefficient as possible. That means more money and less results. Meri Beckwith is building the anti-CRO: Lindus Health—to solve this problem. 0:00 Intro 1:39 The big problem in drug discovery 4:10 Why do CROs exist? 7:24 The incentive problem in drug discovery/CROs 10:57 Phar...2023-10-3135 minBig Picture MedicineBig Picture Medicine#125 The $350M Startup Creating Perfect Memory (Rewind.ai — CEO Dan Siroker)Rewind.ai just raised their Series A at a valuation of $350M. Investors include Andreesen Horowitz, Reddit’s Alexis Ohanian and OpenAI’s Sam Altman. Rewind sits on your computer and phone, and watches everything you do. Then you can ask it questions like: What was that really great Mediterranean recipe I looked at last month? Or I’ve got a call with a client next week, can you summarise every interaction I’ve had with them? But here’s where it becomes even weirder, powerful. They’ve announced the Rewind Pendant, a small audio recorder that sits on your chest...2023-10-2449 minBig Picture MedicineBig Picture Medicine#124 Wearable Data is Bullsh*t Debate — Maitham Dib (Vital YC21)People are wearing Apple Watches to their wedding days. Has this whole 'quantified self' movement gone bananas? Is any of this data actually useful? I spoke to Maitham Dib about this. He's building Vital (YC21); a startup which makes all wearable/lab data available to other startups/companies. 0:00 Wearable data is mostly useless 3:22 The case for wearable data 6:37 Wearable data is mostly useless 8:06 Wearable data is useful 10:16 The big opportunity with wearable/lab data (startups) 14:15 Naivety as a superpower (Paul Graham) 15:45 Why building Vital is so hard 19:31 Pros/cons of an infrastructure play in healthcare 20:51 How to enterprise sales 24:09...2023-09-2029 minBig Picture MedicineBig Picture Medicine#123 How To Write Killer Healthcare Content — Healthcare Huddle (acquired by Workweek)Dr Jared Dashevsky writes Healthcare Huddle (acquired by Workweek). He's scaled to over 30,000 subscribers. And it was pretty simple. Here are 12 frameworks that work for healthcare content creation (and mistakes to avoid). 0:00 Intro 1:14 Consistency is king; systematise it 7:40 McKinsey reverse pyramid principle for writing 9:10 You need to have a unique/controversial take 11:41 Content for network building 15:51 Lean startup thinking does not work for content 20:35 Nobody cares about errors 25:52 Injecting personality is a competitive advantage 29:32 Boring content will make you...2023-09-1552 minBig Picture MedicineBig Picture Medicine#122 Why AI Drug Discovery Is So Hard — Dr Imran Haque (Recursion)Despite $billions of investment into the sector — there are still no AI discovered drugs on the market. Why? Recursion Pharmaceuticals (NASDAQ: RXRX) is one of the hottest AI drug discovery companies on the market. Especially after NVIDIA's $50M investment into them. Dr Imran Haque (SVP of AI and Digital Sciences) explains why AI drug discovery is so tricky — and when it's arriving. 0:00 Intro 0:42 Decoding biology (the big idea) 2:18 Why is AI drug discovery harder than it looks? 4:48 Simulating the Sims (game) vs AI drug discovery 6:58 Building data for AI drug discovery 14:47 Recursion's successes and failures 24:22 The barriers to AI drug...2023-09-0440 minBig Picture MedicineBig Picture Medicine🔥 NVIDIA Pumped $50M Into This Startup You've Never Heard Of (TechBio)0:00 NVIDIA's $50M investment into Recursion Pharmaceuticals 2:28 NVIDIA is becoming a seed investor 3:45 Bull case for Recursion Pharmaceuticals 9:20 Recursion's two big acquisitions 13:05 How are Recursion going to make money? 14:15 Recursion is overhyped 19:45 Recursion is unprofitable 22:21 Kim Kardashian's full body MRI scan 26:03 Longevity doctor's advice to Kim K 31:49 Speculating on Kim K's longevity regime (what she takes) 35:00 Outro and feedback Podcast Links YouTube: https://www.youtube.com/@bigpicturemedicine Apple: https://podcasts.apple.com/gb/podcast/big-picture-medicine/id1500446262 Spotify: https://open.spotify.com/show/5707RPmWOJkVZyUHNRSUfS?si=96c7fff6bccb456a People Dr Imran Mahmud: https://www.imranmahmud.com/ Dr Adam Bataineh: https...2023-08-2037 minBig Picture MedicineBig Picture Medicine#121 Raising $17M Uber for Medical Scans — Charlie Bullock (Scan.com)Ever waited months for a scan? Scan.com is making getting a scan as easy as booking an Uber. Behind the scenes of the disruptor changing medical imaging forever. 0:00 Race to the bottom? 1:34 AirBnB 11 star framework 9:57 Scan.com looks really easy to build — what's hard about it? 12:19 Lessons from working at Deliveroo 15:14 How do you make a lot of money? 19:41 Buying the domain name Scan.com 24:16 How to build a marketplace business 27:50 The perils of price transparency 30:36 What I would do to build a competitor 32:43 You need grit when building a health startup 35:46 Billion $ health ideas Podcast Links YouTube: ht...2023-08-1038 minBig Picture MedicineBig Picture Medicine🔥 What David Sinclair is Hiding From Elon Musk0:00 David Sinclair's controversial claim 1:39 Bull v bear case 6:23 David Sinclair's history of exaggerating and profiteering 8:34 Adam Neuman's involvement 11:40 Raising from unsophisticated investors 16:30 Why aren't big pharma interested in longevity? 22:45 Cynics are right, optimists get rich 25:26 Will a longevity drug be the most valuable therapeutic ever made 28:52 Feedback and outro David Sinclair's Tweet: https://twitter.com/davidasinclair/status/1679178670743732249?s=20 David Sinclair's Research Paper: https://www.aging-us.com/article/204896/text Elon Musk Tweet: https://twitter.com/davidasinclair/status/1679504700285104129?s=20 Dr Charles Brenner's Critique of Sinclair: https://twitter.com/CharlesMBrenner/status/1679213673771057152?s=20 Podcast Links YouTube: https://www.youtube.com/@bigpicturemedicine Apple: https://p...2023-08-0133 minBig Picture MedicineBig Picture Medicine🔥 Regulators Hate Doctor ChatGPT (Here's Why) — Dr Hugh Harvey (Hardian Health)0:00 Why not let the builders build? Move fast and break things? 1:56 Why don't you ban people from googling their symptoms? 3:28 Is a disclaimer enough? 5:27 Why are LLMs difficult to regulate? 10:13 Move fast and kill patients — principal agent problem 12:23 People aren't idiots (they are) 14:20 Dr ChatGPT will never work 17:35 Spotting bubbles in healthcare 19:20 How much time does regulation add onto medical device approval?21:40 Can we ever regulate LLMs? Podcast Links YouTube: https://www.youtube.com/@bigpicturemedicineApple: https://po...2023-07-2423 minBig Picture MedicineBig Picture Medicine🔥 Spotify Founder's Longevity Startup: Bear v Bull Case (Neko Health)Daniel Ek (Spotify Founder) has raised $65M for his new longevity startup: Neko Health. 0:00 What is Neko Health 2:18 They're doing nothing new 5:33 The bull case; why it's going to be huge 7:47 How are they possibly going to make money!? 18:30 Why aren't they doing full body MRI? 20:26 The bear case; why this will fail 25:13 Smells a bit hypey 29:15 The risks of longevity startups and early testing 35:41 The lowdown 37:47 Unexpected way of making $$$ 40:00 Outro and feedback Podcast Links YouTube: https://www.youtube.com/@bigpicturemedicine Apple: https://podcasts.apple.com/gb/podcast/big-picture-medicine/id1500446262 Spotify: https://open.spotify.com/show/5707RPmWOJkVZyUHNRSUfS?si=96...2023-07-1042 minBig Picture MedicineBig Picture Medicine🔥 Apple's Plan to Dominate Healthcare (And Why It Will Fail)0:00 Leaked secret Apple health report 5:06 What Apple are up to in healthcare 9:21 Decentralised clinical trials 11:35 Apple healthcare leaked documents controversy 15:38 Apple is going to become a health insurer 23:07 Imran's advice to Tim Cook 26:11 Being a healthcare provider is unprofitable 28:12 Apple will make a longevity/subscription health play 30:27 Outro and feedback Links mentioned Apple Struggles in Push to Make Healthcare Its Greatest Legacy (Wall Street Journal): https://www.wsj.com/articles/apple-struggles-in-push-to-make-healthcare-greatest-legacy-11623832200 Podcast Links 2023-07-0334 minBig Picture MedicineBig Picture Medicine#120 Billion $ Healthtech 'Soonicorn' Huma: Lessons from Jony Ive and Big Pharma — Dan Vahdat (CEO)Huma is about to reach a 1 billion dollar valuation, and is thriving while other digital health companies are dying. But what’s their secret sauce? Dan Vahdat is the Johns Hopkins dropout — who meticulously studied the successful business practices of big pharma, and using these, has created the 'soonicorn' digital health company that’s about to take over the world of remote patient monitoring and decentralised clinical trials. 0:00 Intro 1:11 Focusing on one big thing is bullsh*t 6:33 Lessons from Jony Ive 10:02 Healthtech infrastructure play 16:04 'Ownership is everything' discussion 20:18 If you maximise impact, commercial will come 24:00 Bad design hurts me 28:56 You do...2023-06-2639 minBig Picture MedicineBig Picture Medicine🔥 Beauty and the Bucks: Inside GetHarley's $52M Triumph in Skincare0:00 Intro 1:04 The genius business model of GetHarley 5:26 How important is marketing? 50% of revenue 14:57 Why aren't they doing cooler more innovative stuff? 22:38 What verticals would we expand GetHarley's biz model to 24:37 Vitamin vs painkiller 27:49 Why have investors put so much money into GetHarley? 31:00 Feedback and outro Links mentioned GetHarley, a skincare telehealth and consultation platform, raises $52M (TechCrunch): https://techcrunch.com/2023/06/06/get... Podcast Links YouTube:    / @bigpicturemedicine   Apple: https://podcasts.apple.com/gb/podcast... Spotify: https://open.spotify.com/show/5707RPm... People Dr Imran Mahmud: https://www.imranmahmud.com/ Dr Adam Bataineh: https://twitter.com/DrAdamBat / https://numenor.health Dr Mustafa Sultan2023-06-1932 minBig Picture MedicineBig Picture Medicine🔥 News: Pills for Profit — The Dark Side of D2C Health Startups0:00 Intro 0:20 DEA comes after DTC health startups 3:18 How DTC health startups hacked customer retention 10:30 Will this kill the economics of D2C health startups? 12:57 How would we solve the problem 15:30 New LLM Paper in Nature 28:18 Audience feedback and outro Links Mentioned Cerebral Pushed ADHD Prescriptions And Failed To Report Data Breaches, Ex-Executive Alleges In Lawsuit (Forbes): https://www.forbes.com/sites/katiejennings/2022/04/28/cerebral-pushed-adhd-prescriptions-failed-to-report-data-breaches-ex-executive-alleges-in-lawsuit/DEA's proposed telehealth rules pull back COVID-era remote prescribing flexibilities: https://www.fiercehealthcare.com/telehealth/deas-proposed-telehealth-rules-tighten-covid-era-remote-prescribing-regulations 2023-06-1333 minBig Picture MedicineBig Picture Medicine#119 The Unusual Path to Make a Billion $ Men's Health Startup — Numan CEO (Sokratis Papafloratos)Numan have raised $70M+ and are set to become the biggest men's digital health startup, ever. Here's how. From their eccentric Founder. 0:00 Intro 0:42 Valuation 1:46 Lessons from Calm.com 4:49 Raising aggressively 7:35 Successful entrepreneurs are not hyper intelligent 10:38 When to quit 14:43 The Social R Number 18:14 Being nice gets you nowhere 22:24 Numan's marketing genius 38:09 What Adam Neumann got wrong 45:12 Narrative is like really important 49:13 Being honest about your motivations 52:59 Outro Podcast Links YouTube: https://www.youtube.com/@bigpicturemedicine Apple: https://podcasts.apple.com/gb/podcast/big-picture-medicine/id1500446262 Spotify: https://open.spotify.com/show/5707RPmWOJkVZyUHNRSUfS?si=96c7fff6bccb456a People Dr Mustafa S...2023-06-0553 minBig Picture MedicineBig Picture Medicine🔥 News: The Rise and Demise of Babylon Health0:00 Intro 0:18 Ali Parsa's Immigrant Story 1:57 Picking a Problem That Was Too Big 4:15 The Supply Induced Demand Problem 5:55 The Unit Economics Problem 7:37 The Misaligned Incentives Problem 10:11 The Friction Problem 12:06 The First Mover Disadvantage 13:30 Raising Too Much Money 14:55 The SPAC Problem 17:40 The Pig With Lipstick Problem 22:07 Should Founders be Liberal with the Truth? 26:06 What Will the Next Health Unicorn Be? Articles Mentioned Babylon shareholders wiped out in restructuring deal: https://www.ft.com...2023-05-1729 minBig Picture MedicineBig Picture Medicine🔥 News: VC Dirty Money and Trillion $ Alzheimer's Opportunity0:00 Intro 0:38 VC Dirty Money (LP Sources) 8:30 Power Dynamics Founder vs VC 12:56 Trillion $ Alzheimer's Opportunity 14:26 Eli Lily's New Alzheimer's Blockbuster (?) Donanemab 19:01 More Issues with Donanemab Phase III Results 21:48 Will Anyone Pay for Donanemab? 24:13 Donanemab Side Effects 27:15 Startup Opportunities in Alzheimer's  31:34 Outro Articles Mentioned Founders need to take a stand against VC's 'dirty money’: https://sifted.eu/articles/founders-vc-dirty-money Eli Lily Donanemab Phase III Press Release: https://investor.lilly.com/news-releases/news-release-details/lillys-donanemab-significantly-slowed-cognitive-and-functional C...2023-05-1232 minBig Picture MedicineBig Picture Medicine🔥 News: ChatGPT vs Doctors: Who Will Win?Papers Mentioned— ChatGPT better + more empathetic than human doctors (JAMA Int Med Paper): https://jamanetwork.com/journals/jamainternalmedicine/fullarticle/2804309 Detecting eye disease using AI (Nature Biomedical Engineering): https://www.nature.com/articles/s41551-022-00867-5 Predicting dementia using LLMs (PLOS Digital Health): https://pubmed.ncbi.nlm.nih.gov/36812634/ AI recognises race from black and white X rays (Lancet Digital Health): https://www.thelancet.com/journals/landig/article/PIIS2589-7500(22)00063-2/fulltext VC dirty money article: https://sifted.eu/articles/founders-vc-dirty-money 0:00 Intro 0:30 ChatGPT vs...2023-05-0434 minBig Picture MedicineBig Picture Medicine🔥 News: It’s Time to Build in Healthcare (a16z) and Why are VCs Miserable?0:00 Intro 0:32 Why are VCs so unhappy? 2:18 What’s hard about being a VC? 3:56 Hustle culture, FOMO, always-on culture in VC 9:54 Is it ever easy to become rich? 12:22 It’s time to build in healthcare 15:31 Why is healthcare so hard for big tech? 17:31 Reasons why healthcare is easier than you think 21:04 Imposter syndrome for tech people entering healthcare 24:03 Would you build another healthcare startup? 25:12 Outro Joined by: Dr Imran Mahmud: Investor, Oxford-trained doctor, ex-M...2023-04-2627 minBig Picture MedicineBig Picture Medicine🔥 News: AI Too Powerful? Peter Attia's Longevity Bible and Why Are Americans Dying So Young?0:00 Intro 0:54 Is AI Too Powerful? 17:59 Outlive, Peter Attia's New Longevity Bible 45:16 Why Are Americans Dying So Young? Joined by:  Dr Adam Bataineh: Longevity doctor and Co-founder Span Health (acquired by EightSleep).  Dr Imran Mahmud: Investor, Oxford-trained doctor, ex-Mckinsey and Co-founder of NYE Health.  Dr Mustafa Sultan: Creator of Big Picture Medicine and Doctor.2023-04-0351 minBig Picture MedicineBig Picture Medicine🔥 News: Microsoft's GPT-4 Healthcare Play and Self-Driving Drug Development0:00 Intro 1:00 AI drug development 7:04 Big picture impact of AI drug development 9:14 Counterintuitive facts about drug development 11:06 Why can't we just make novel drugs with AI? Biology is hard 19:06 Microsoft's GPT-4 healthcare play 26:48 The hardest thing about health startups 31:49 Outro Joined by:  Dr Adam Bataineh: Longevity doctor and Co-founder Span Health (acquired by EightSleep).  Dr Imran Mahmud: Investor, Oxford-trained doctor, ex-Mckinsey and Co-founder of NYE Health.  Dr Mustafa Sultan: Creator of Big Picture Medicine and Doc...2023-03-2432 minBig Picture MedicineBig Picture Medicine🔥 News: Semaglutide (Wegovy) TikTok Conspiracy, Alcohol Disruptor and Where Are the UK Healthtech Exits?0:00 Intro  1:27 Semaglutide (Wegovy) lowdown, use in longevity clinics  6:38 Is a 'pill for everything' a bad thing?  10:39 What's going to happen to all the DTC weight loss startups?  13:37 Is Semaglutide a TikTok conspiracy by big pharma?  14:55 The new alcohol-free alcohol, GABA  21:07 Where are all the big UK healthtech exits?  24:16 US investors/entrepreneurs are more ambitious  27:41 Is DTC digital health the way to go?  32:40 Is there much point building in the UK?   Joined by:  Dr Adam Bataineh: Longevity doctor and Co-foun...2023-03-1034 minBig Picture MedicineBig Picture Medicine🔥 News: David Sinclair's New Startup, Transhumanist Gene Editing to Sleep Less and ChatGPT for Drug Development0:00 Intro  1:09 David Sinclair's New Startup   11:25 ChatGPT for Drug Development  28:32 Transhumanist Gene Editing to Sleep Less  37:38 Banter/Audience Feedback   Dr Adam Bataineh: Longevity doctor and Co-founder Span Health (acquired by EightSleep).  Dr Imran Mahmud: Investor, Oxford-trained doctor, ex-Mckinsey and Co-founder of NYE Health.  Dr Mustafa Sultan: Creator of Big Picture Medicine and Doctor.2023-03-0343 minBig Picture MedicineBig Picture Medicine#067 Syria -> Oxford University — Dr Alexey YoussefWhat does it take to leave Syria during the Civil War and become the first Syrian Rhodes Scholar? Dr Alexey Youssef trained in Medicine in Syria — where he practiced during the Civil War, during which the hospital he worked in was bombed. He then became the first Syrian to gain the prestigious Rhodes Scholarship at Oxford University and then started his PhD in Clinical AI. He has now started his MBA at the Harvard Business School. We talk about some of his research which focuses on building Electronic Health Records in low and middle income co...2021-10-2723 minBig Picture MedicineBig Picture Medicine#066 Bias in Medical AI — Prof Ziad Obermeyer (Berkeley School of Public Health)How can we design AI systems which remove human bias — rather than perpetuate it? Ziad Obermeyer is Associate Professor and Blue Cross of California Distinguished Professor of Health Policy and Management at the Berkeley School of Public Health where he researchers and teaches on the intersection of machine learning and healthcare. Some of his most interesting research focuses on algorithmic bias, and how we can better build AI systems which avoid perpetuating and falling into these traps. We talk about his fascinating story, how he created an AI algorithm which actually reduced bias and superseded hu...2021-10-0447 minBig Picture MedicineBig Picture Medicine#065 Becoming a Great Clinical Academic — Prof Neil SebireWhat does it take to become a great clinical academic? Neil Sebire is a Professor of Pathology at the Great Ormond Street Hospital (GOSH) which is the country’s leading children’s research hospital as well as the Chief Clinical Data Officer at Health Data Research UK He has loads and loads of other accolades including over 700 published papers, a H index of 88 and 32,000 citations so it’s always a privilege to get his thoughts. This is the third podcast interview I’ve done with him. In Episode 2 of this podcast we talked about hi...2021-09-2658 minBig Picture MedicineBig Picture Medicine#064 Overnight Success — Dr Yusuf Sherwani (CEO QuitGenius)Yusuf Sherwani is the Co-founder and CEO of QuitGenius — a digital clinic for addiction. QuitGenius started life as a smoking cessation app, which Yusuf and his Co-founders created whilst at Imperial College Medical School. They have since expanded to the US and have raised just under $80M dollars. We talk about the overnight success, and how it wasn’t really overnight. We talk a lot about decision making and useful mental models as a healthtech founder, and some of Yusuf’s failures and how he dealt with them. You can find me on Twitte...2021-08-2545 minBig Picture MedicineBig Picture Medicine#063 Chief Medical Officer, AstraZeneca — Dr Ann TaylorDr Ann Taylor studied at Harvard Medical School, practiced as an Endocrinologist at Mass General Hospital before shifting over to Pharma — now sitting as AstraZeneca’s Chief Medical Officer. This episode's full of wisdom, we talk about being a generalist vs a specialist at life, what she learned from leaving Medicine and entering Pharma and her tips for medics who want to do great things outside of the clinic. I hope you enjoy.2021-08-1436 minBig Picture MedicineBig Picture Medicine#062 Sleep and the Evidence Base of Digital Health — Prof Colin Espie (Co Founder Big Health)Colin Espie is Professor of Sleep Medicine at Oxford University as well as Co-Founder and Chief Medical Officer of Big Health. With insomnia, there are two mainstays of treatment. The first is medication or drugs, and the second is Cognitive Behavioural Therapy (or CBT). CBT has traditionally required face-to-face treatment from a psychologist, and can be difficult to access for patients in a constrained health service. Far easier, the criticism goes, to just give someone a pill. Fundamentally, the problem is that prescription drugs are very scalable and relatively cheap. Face-to-face CBT on the other...2021-07-0838 minBig Picture MedicineBig Picture Medicine#061 The Joys of Fundraising — Cyndi Williams (CEO Quin)Cyndi Williams is the Co-founder and CEO of Quin; a digital therapeutic for type 1 diabetes. The app provides personalised, data-led support for insulin dosing decisions, based on physiological and behavioural factors. Quin have raised £3.6 million pounds to date. We talk about the process of building Quin, the joys and tribulations of fundraising, crowdfunding and the life of a CEO. I hope you enjoy. You can find me on Twitter @MustafaSultan and subscribe to my newsletter on www.musty.io2021-06-2925 minBig Picture MedicineBig Picture Medicine#060 Open Source is the Future of Medicine — Dr Marcus BawSecrets, in Medicine, are a crime against humanity. Dr Marcus Baw holds an unusual career as a GP, Emergency Physician and health hacker. He makes a controversial claim: That we have an ethical duty to openly share our technological innovation — and anything short of this is a crime against humanity. Links from Marcus Digital Health Networks (CCIOs, CIOs, CSOs, Caldicott Guardians, Clinicians Who Code and more) discourse.digitalhealth.net Open Health Hub - completely open discussion of all things open sourcey in healthcare https://openhealthhub.org/ My OSITO...2021-06-2143 minBig Picture MedicineBig Picture Medicine#059 Meritocracy — Prof Sir John BurnProfessor Sir John Burn is Professor of Clinical Genetics at Newcastle University, a Non-Executive Director of NHS England and Vice Chairman of QuantumDx. His story is fascinating and slightly unusual — because he began life from humble beginnings in a small village in the North East of England. We talk about meritocracy, how to be a showman and why business and clinical academia are really very similar. I hope you enjoy. You can find me on Twitter @MustafaSultan and subscribe to my newsletter on www.musty.io2021-05-0335 minBig Picture MedicineBig Picture Medicine#058 BMJ Editor-in-Chief — Dr Fiona GodleeWhat's the biggest existential threat to the BMJ? Dr Fiona Godlee is the Editor-in-Chief of the British Medical Journal and is an Executive Director of the BMJ Company. She trained as a General Physician in Cambridge and London, before joining the BMJ as an Editorial Registrar. Dr Godlee is incredibly interesting and forthcoming with the realities of running a medical journal — we talk about how the BMJ is not just a medical journal but a societal intervention, existential threats to the BMJ, the future vision and what Dr Godlee’s learned about leadership on h...2021-04-2636 minBig Picture MedicineBig Picture Medicine#057 Capturing 5% of Google Searches — Daniel Nathrath (CEO Ada Health)How do you capitalise on a problem spanning 5% of Google searches? Daniel Nathrath is the Co-founder and CEO of Ada Health; a self-assessment health app for patients. Ada has 10 million users, 250,000 5-star ratings and they’ve raised just shy of $100M. They’ve been backed by Philip Schindler (Google’s Chief Business Officer_ and William Tunstall-Pedoe; who created Amazon Alexa. We discuss some of the details behind starting Ada and its initial reception from doctors, some of its successes and future direction and finally we talk about Daniel’s leadership philosophy and some...2021-04-2046 minBig Picture MedicineBig Picture Medicine#056 First Principles — Melissa Morris (CEO Lantum)How do you save the NHS £1 billion? Melissa Morris is founder and CEO of Lantum; a company aiming to save the NHS £1 billion in workforce costs. She started her career as a McKinsey Management Consultant and has since raised over £20M and grown Lantum to 60 employees. We talk about how she grew Lantum and got it adopted in the NHS, first principles, how to take advice, stress as a founder and I ask her about some dubious rumours I've heard about McKinsey. I hope you enjoy. You can find me...2021-04-1333 minBig Picture MedicineBig Picture Medicine#055 Getting Punched in the Face — Adnan Iqbal (CEO Luma Health)Founding a company is like getting punched in the face, a lot. Adnan Iqbal is CEO and Co-Founder at Luma Health; a company which better connects patients and doctors. He’s raised over $30M and scaled to over 450 US health systems and clinics. Adnan studied Biology at Berkeley, then did his masters at Cambridge before working at Genentech — a large US biotech company. He then went to the Stanford Graduate School of Business, and that’s when him and his co-founder Tashfeen Ekram (a medical doctor) started working on Luma. This episode is litter...2021-04-0750 minBig Picture MedicineBig Picture Medicine#054 Becoming a Superconnector — Will Gibbs (Octopus Ventures)How can you become a superconnector? Will Gibbs leads the Future of Health team at Octopus Ventures; one of the largest Venture Capital firms in Europe — with over £1.3bn under management. Will studied Classic Archaeology and Ancient History at Oxford, before trying his hand at pig farming and then becoming an investor at Octopus. We talk about the pros and cons of being a doctorpreneur, being right when others are wrong and how to become a superconnector. I hope you enjoy. You can find me on Twitter @MustafaSultan and sub...2021-03-2931 minBig Picture MedicineBig Picture Medicine#053 Chasing Failure — Dr Mala Mawkin (Cellen)What does it mean to become addicted to failure? Dr Mala Mawkin is a Doctor, Head of Market Development at Cellen and hosts the Royal Society of Medicine’s Digital Health Podcast. She's also been featured on Forbes 30 under 30 and Vogue UK’s Top 10 Rising Female Stars — impressive — considering she graduated from Medical School just two years ago. We talk about persistence, chasing failure, leaving Medicine and what it’s like as a woman in healthtech. I hope you enjoy. You can find me on Twitter @MustafaSultan and subscribe to my news...2021-03-2330 minBig Picture MedicineBig Picture Medicine#052 Digital Twins in Clinical Trials — Dr Charles Fisher (CEO Unlearn.ai)How can you use digital twins for faster clinical trials requiring fewer patients? Dr Charles Fisher is the CEO and Founder of Unlearn.ai — which uses digital twins to reduce the number of patients required in clinical trials. In a clinical trial, you usually have a treatment group who receive the drug/treatment, and a control group who receive a placebo. This means that a large number of patients need to be given a placebo — a fake or dummy version of the treatment with no therapeutic effect. But using generative machine learning models, you...2021-03-1538 minBig Picture MedicineBig Picture Medicine#051 Surgeon -> VC — Dr Benedict Evans (InHealth Ventures)What is VC and how do I raise it? Dr Benedict Evans was set on becoming an orthopaedic surgeon, before he fell out of love with Medicine and saw a system in which he could make a positive change, at scale. So he left his surgical training programme and joined McKinsey as a healthcare expert. He then worked as Associate Director of transformation at St Georges Hospital Trust in London before joining InHealth Ventures, which is a $50M early stage fund looking to invest in companies who can transform health outcomes across Europe and the...2021-03-0843 minBig Picture MedicineBig Picture Medicine#050 Imperial -> McKinsey -> Mayo Clinic (US) — Dr Ikram HaqWhat's the difference between UK and US medical training? Dr Ikram Haq trained at Imperial College Medical School, interning at McKinsey before starting training at the Mayo Clinic in the US — considered one of the best hospitals in the world. We talk about the difference between US and UK medical training, how Ikram got to where he is — covering both the high level philosophies and granular details — as well as how he deals with failure. I hope you enjoy. You can find me on Twitter @MustafaSultan and subscribe to my newsletter on www...2021-02-2836 minBig Picture MedicineBig Picture Medicine#049 AI Therapy and Going Viral — Ross Harper (CEO Limbic)Can you automate therapy? Ross Harper studied both Neuroscience (Cambridge) and Mathematical Modelling (UCL) — combining the two into his lovechild: Limbic — an AI therapy assistant. We talk about the challenges of working in mental health, different business models in the area and how Ross sold his face to pay off his uni debt. I hope you enjoy. You can find me on Twitter @MustafaSultan and subscribe to my newsletter on www.musty.io 2021-02-2234 minBig Picture MedicineBig Picture Medicine#048 Decision Making in Health Leadership — Prof Sam ShahHow do you make good decisions in health leadership? Professor Sam Shah is founder of the Faculty of Digital Health, Chief Medical Strategy Officer at Numan and former Director of Digital Development at NHS X. He has extensive experience in consulting, health policy and healthtech. We talk about good decision making in health leadership roles, how to make clinicians digitally proficient, and some of his failures along the way. I hope you enjoy. You can find me on Twitter @MustafaSultan and subscribe to my newsletter on www.musty.io2021-02-1341 minBig Picture MedicineBig Picture Medicine#047 Longevity: The Disposable Soma Hypothesis — Prof Tom Kirkwood CBEHow can you extend life? Professor Tom Kirkwood is Emeritus Professor at Newcastle University where he headed the Institute for Ageing and Health. He delivered the famous Reith Lectures and was awarded a CBE in 2009. Perhaps most famously he put forward the ‘Disposable Soma Hypothesis’ — which postulates that the body has a limited budget of resources and energy. It must therefore make a compromise between living longer (longevity) and activities which will help it reproduce. Interestingly, he also invented the INR in the 80s, which is a blood test used everyday by doctors to mea...2021-02-0358 minBig Picture MedicineBig Picture Medicine#046 Radiology -> Venture Capital — Dr Fiona Pathiraja (Crista Galli Ventures)What are the pros and cons of VC funding as a doctorpreneur? Dr Fiona Pathiraja was a Consultant Radiologist at UCLH and is now Founder and Managing Director of Crista Galli Ventures — a pan-European healthtech fund. She also holds an MBA and an MPH. We dive into her story, Venture Capital and she gives loads of valuable advice for doctorpreneurs.  I hope you enjoy. Crista Galli Ventures: https://www.cristagalli.com You can find me on Twitter @MustafaSultan and subscribe to my newsletter on www.musty.io2021-01-2526 minBig Picture MedicineBig Picture Medicine#045 Former Special Advisor to the Health Secretary — Richard SloggettSo it's your first day as Health Secretary — what do you do!? Richard Sloggett was former Special Advisor to the Health Secretary (Matt Hancock) during which he worked across public health, the NHS and social care. He’s also Senior Fellow at the think tank Policy Exchange and has been named one of the 100 most influential people in healthcare policy by the Health Service Journal. Richard has also recently founded a global healthcare policy research centre: Future Health. The Centre is researching health and economic opportunities in building more resilient and preventative healthcare systems enabled by n...2021-01-1328 minBig Picture MedicineBig Picture Medicine#044 Rare Disease AI — Rudy Benfredj (CEO Mendelian)How can we use models to diagnose patients with rare diseases earlier? Rudy Benfredj is Co-founder and CEO of Mendelian; who are helping doctors find and diagnose rare disease patients earlier. Rare diseases are individually rare, but collectively quite common — they affect 1 in 17 people. With 8000+ rare diseases and some only affecting a handful of people across the globe — rare diseases take an average of 7 years to diagnose — which is dubbed the diagnostic odyssey. Rudy is super interesting and I pick his brain about how artificial intelligence can be used help reduce the diagnostic odysse...2021-01-0138 minBig Picture MedicineBig Picture Medicine#043 Brain Computer Interfaces — Prof Karl FristonProfessor Karl Friston is the most frequently cited neuroscientist in the world. Some of his most fascinating ideas centre around brain imaging, and of course, his infamous free energy principle — a grand unifying principle for cognitive science and biology. Professor Friston is incredibly insightful and patient with my questions — which at times feel like a 5 year old playing with a grand chess master. We speak about consciousness, brain computer interfaces as well as Professor Friston’s story and advice for young academics. I try to deconstruct some of what his enabled him to put forward so many novel...2020-12-251h 04Big Picture MedicineBig Picture Medicine#042 Spatial Cognition — Prof Hugo Spiers (SpiersLab)What can you learn from studying the brains of London cabbies? Hugo Spiers is Professor of Cognitive Neuroscience at UCL. He studies how we remember, navigate and imagine space. Some of his most interesting work has examined the brains of London cabbies who are required to learn the roads of London in painstaking detail. Now he leads the SeaHeroQuest project, in which his team are studying dementia using a mobile game. We talk about his research — which in my opinion is fascinating but I delve a bit deeper — asking how ordinary people can them...2020-12-1747 minmustafaphotographermustafaphotographerGüzel Hikayeler I Bana Bir Tüfek Verin - Sultan Abdülhamid HanSoğuk Bir Kış Günü Sürgün Edilen Sultan Abdülhamd Han'dan vatanına sevgi... --- Send in a voice message: https://anchor.fm/mustafa-karacan6/message2020-12-1204 minBig Picture MedicineBig Picture Medicine#041 Leadership Shorts: Dr Nadine Hachach-Haram BEMDo you need to be a d**k to be a good leader? Here's what Dr Nadine said... Dr Nadine Hachach-Haram BEM is a plastic surgeon and CEO of Proximie — an augmented reality platform for virtual surgical collaboration. Rather than telemedicine it’s about telepresence. It means that a surgeon in the UK could open up their web browser, and see what another surgeon across the world is doing in real time and collaborate. Proximie has had incredible impact: it’s helped people in need across the world access surgical care, it’s been used by NHS s...2020-12-1102 minBig Picture MedicineBig Picture Medicine#040 Leadership Shorts: Dr Eric TopolDo you need to be a d**k to be a good leader? Here's what Dr Eric Topol said... Dr Eric Topol is in the top 10 most cited doctors in the history of Medicine. He is a cardiologist, geneticist and digital medicine expert — and was commissioned by the UK’s Health Secretary to write a report to prepare the NHS for the digital future: The Topol Review. Dr Topol has three best selling books on the future of Medicine: the Creative Destruction of Medicine, The Patient Will See you Now and Deep Medicine: How Artificial Inte...2020-12-1002 minBig Picture MedicineBig Picture Medicine#039 Do You Need to be a D**k to be a Good Leader? (Series Launch)Look around and you’ll be surrounded by let’s face it... d**ks. Not just in politics and business — but also in Medicine. We’re taught lots about the multidisciplinary team and how important each member is — but that’s not always the experience in the real world. What I really want to know is: Do you need to be a d**k to be a good leader? And not just the knee jerk response of: "of course not". I want to know the ins and outs, and maybe — if sometimes it’s useful to be a bit bras...2020-11-3001 minBig Picture MedicineBig Picture Medicine#038 Ferraris to Fitness — Dr Yusef Smith (Propane Fitness)Why switch from Investment Banking to Medicine? Dr Yusef Smith is a doctor, competitive gymnast and powerlifter. In a previous life, he was an investment banker before packing it in and training in Medicine. Whilst at Medical School he started Propane Fitness — the passive income from which has now overtaken his salary as a doctor. Yusef is a friend and one of the most contemplative people I know. We talk about passive income, physical and mental health, tools for productivity and why Yusef went on a 10 day silent meditation retreat. You can find me...2020-11-2239 minBig Picture MedicineBig Picture Medicine#037 Deliveroo for Drugs — Stephen Bourke (Co-Founder Echo)Stephen Bourke is the co-founder of Echo; the online pharmacy. If you haven’t heard of Echo, it’s a bit like Deliveroo for your medication. It delivers repeat prescriptions to your door, free of charge and hassle-free. It was acquired by McKesson, the group who own Lloyds Pharmacy in 2019. This is a really valuable conversation and Stephen is hilarious, honest and gives a tasty inside scoop into the world of online pharmacy. We talk about how to improve patient adherence, how Echo rose to the top despite not being the first company of its kind by a lo...2020-11-1542 minBig Picture MedicineBig Picture Medicine#036 My Notes on Leadership and Success — Sir Bruce Keogh (Former National Medical Director)Sir Bruce Keogh was National Medical Director for over a decade — leading clinical policy and strategy as well as being responsible for clinical leadership, quality and innovation. Sir Bruce was a celebrated cardiac surgeon prior to this, and during his tenure as Medical Director — he was most notably responsible for making clinical outcomes the currency of the NHS. He has been declared the most influential clinician in the NHS by the Health Service Journal for three years and was appointed Knight Commander of the Order of the British Empire in 2003. Honestly, I was nervous about spea...2020-11-0842 minmustafaphotographermustafaphotographerFatih Sultan Mehmed (AVNİ) - İstememPeygamber Efendimize Aşık bir padişah, şair. İsmi Avi yani Fatih Sultan Mehmed. Ben Sultan Fatihim, önündeyim İstanbul’un. Yakarım bu şehri yüzünde bir tebessüm için. Yoksa gül yüzünü güldürmeyen sultanlığı istemem, İstanbul’u istemem. Ben bir garip yunusum, yazdığım sensin, yandığım sen. Senden gayrı bir aşka ben kalemi istemem, kağıdı istemem. Ben senin ümmetinim, sensin benim efendim. Senden gayrı, senden başka efendi istemem, sevgili istemem, istemem… --- Send in a voice message: https://a2020-11-0603 minBig Picture MedicineBig Picture Medicine#035 The Clinician Scientist — Dr Joe Ledsam (Google/DeepMind)How does a doctor start working for DeepMind/Google? 🤖  Joe Ledsam is a Clinician Scientist at Google Japan after formerly working at DeepMind. He started his career off as a doctor, before migrating to research and eventually coming to his current position. He’s worked on some of the most influential medical deep learning papers to date — published in the likes of Nature. For many nerds in Medicine — he’s living the dream. He was recommended to me by Pearse Keane who I spoke to on episode #10, who described him as simply exceptional. We talk abou...2020-11-0226 minBig Picture MedicineBig Picture Medicine#034 The Doctor Policymaker — Dr Simon Eccles (Deputy CEO NHS X & CCIO Health and Care)Dr Simon Eccles is the Chief Clinical Information Officer for Health and Care and Deputy CEO of NHS X. Amongst many responsibilities, he’s accountable for delivery of the Personal Health and Care 2020 programme, and the central expenditure for the NHS’s IT. Whilst doing all of this, he also practices one day a week as a Consultant in Emergency Medicine. He’s funny, he’s opinionated, he has a strong vision and he gives wonderful insight into what it’s like as a doctor policymaker. He talks about what he’s learned along the way, electro...2020-10-1941 minBig Picture MedicineBig Picture Medicine#033 You Need to Learn How to Code — Dr Josh CaseWhy should doctors learn how to code? Josh is really cool. He’s an Australian doctor on a big mission — to empower medics with code. Josh recently released Code Blue: An Introduction to Programming for Doctors. I highly, highly recommend picking this up for a 0–100 guide on coding for medics: https://gum.co/NMtSD  We talk about why you should learn how to code as a medic — but then I push back and challenge Josh — I ask him why you should bother learning how to code when a) no doctor I’ve spoken to in MedTech...2020-10-0439 minBig Picture MedicineBig Picture Medicine#032 AI, Academia and Business — Prof Geraint Rees (Pro-Vice-Provost AI at UCL)Where are the dark horses in medical AI? 🐴  Professor Geraint Rees is the Dean of the Faculty of Life Sciences at UCL, Pro-Vice-Provost of AI and is also the director of UCL Business — its technology transfer arm. His research is primarily in cognitive neuroscience and he has been cited over 35,000 times with a h index of 93. He sits at the intersection of academia, technology and business — so he has a really rich, birds eye perspective on MedTech. I asked him which areas of AI in Medicine don’t get enough attention, the role of private...2020-09-2734 minBig Picture MedicineBig Picture Medicine#031 The NHS Clinical Entrepreneur — Prof Tony Young OBEDo we want a Silicon Valley for healthcare? Professor Tony Young is the National Clinical Director for Innovation at NHS England, co-founder of the UK’s £500M MedTech Campus, founder of the NHS Clinical Entrepreneur Programme and a consultant urological surgeon. Tony was awarded an OBE for services to clinical leadership in the 2019 New Year Honours List. Tony has recently opened applications for the NHS Clinical Entrepreneur programme. Apply here: https://www.england.nhs.uk/aac/what-we-do/how-can-the-aac-help-me/clinical-entrepreneur-training-programme/ This is a really fun conversation — we cover Tony’s story, how and if the UK...2020-09-1754 minBig Picture MedicineBig Picture Medicine#030 AI Too Smart for Clinical Trials: SPIRIT-AI and CONSORT-AI — Professor Alastair Deniston and Dr Xiao LiuA paper published in the Lancet Digital Health found that less than 1% of clinical AI studies reviewed were of sufficient quality to have confidence in their results. This is a huge problem. Dr Xiao Liu and Professor Alastair Denniston are part of the team who published that study — and to tackle this this problem — they have today published the first international standards for the reporting of clinical AI trials. These are called SPIRIT-AI and CONSORT-AI and have today been published in Nature Medicine, the Lancet Digital Health and the BMJ. The goal of these guidelines is t...2020-09-0948 minBig Picture MedicineBig Picture Medicine#029 Life of a Doctor-CEO — Dr Ben Maruthappu MBE (CEO Cera Care)What's it like running a company which has raised $90M? Dr Ben Maruthappu is the co-founder and CEO of Cera Care — a technology enabled home care company. I could speak about Ben’s achievements and accolades for hours, but to give you a whistle stop tour — he is a successful doctorpreneur, has published some very influential papers, and has worked in health policy — perhaps most notably — he was an advisor to Simon Stevens (CEO of NHS England). Ben was awarded an MBE for services to Health and Care technology in the 2020 Queen’s New Year Hon...2020-09-061h 16Big Picture MedicineBig Picture Medicine#028 The Benevolent Leader 😇 — Professor David Lomas (Vice Provost Health UCL)Do you need to be a silverback gorilla to be a good leader? 🦍  Professor David Lomas is the Vice Provost (Health) at University College London and Head of UCL Medical School. He is also a hugely accomplished academic with his most notable work focusing on alpha-1 antitrypsin deficiency. He has a h-index of 95. We talk about lots of things — like the future of medical education,  what makes a good leader and how to make good decisions. Find Prof David Lomas UCL: https://iris.ucl.ac.uk/iris/browse/profile?upi=DALOM96 Y...2020-08-2937 minBig Picture MedicineBig Picture Medicine#027 The Digital ENT Surgeon — Dr Krishan Ramdoo (CEO TympaHealth)Do you want the granular step-by-step on how to launch your own MedTech startup? Dr Krishan Ramdoo was an ENT Surgeon before co-founding TympaHealth; the world’s first all in one hearing health assessment system. It’s essentially a digital otoscope (a scope that helps visualise inside the ear). Traditionally this was an analogue device, so no one else could see what you saw when you examined the ear — but with the Tympahealth system, you can see what the scope is looking at on your phone screen and then save that video to the patient’s record...2020-08-2049 minBig Picture MedicineBig Picture Medicine#026 The AI Radiologist — Dr Hugh Harvey (Hardian Health)What does the future radiologist look like? What does everyone get wrong when regulating their AI startup? Dr Hugh Harvey trained as a consultant radiologist and is now the managing director of Hardian Health; a health-tech consultancy firm. He has had an incredible career, sitting at the interface of Medicine and technology. He was headhunted by Dr Eric Topol to co-chair the Topol Review, he sits on the board of Nature Digital Medicine and was formerly head of regulatory affairs at Babylon Health. He has twice been awarded science writer of the year...2020-08-1623 minBig Picture MedicineBig Picture Medicine#025 How to Get Published — Dr Azeem Alam BEM (Co Founder BiteMedicine)You're an average medical student with no connections — how do you get published!? *Congratulations to Azeem who was awarded the British Empire Medal for services to Medical Education during COVID-19* Dr Azeem Alam completed his surgical AFP training in London and is the co-founder of BiteMedicine — the medical knowledge platform. He shares his step-by-step framework on getting published without a leg up. Find Azeem BiteMedicine: https://www.bitemedicine.com LinkedIn: https://www.linkedin.com/in/azeemalam/ Music: https://www.youtube.com/watch?v=9Ngjub5Ntqk You...2020-08-1325 minBig Picture MedicineBig Picture Medicine#024 The Augmented Reality Surgeon 🖲 — Dr Nadine Hachach-Haram BEM (CEO Proximie)How can a surgeon assist in an operation across the world — using their web browser? Dr Nadine Hachach-Haram BEM is a plastic surgeon and CEO of Proximie — an augmented reality platform for virtual surgical collaboration. Rather than telemedicine it’s about telepresence. It means that a surgeon in the UK could open up their web browser, and see what another surgeon across the world is doing in real time and collaborate. Proximie has had incredible impact: it’s helped people in need across the world access surgical care, it’s been used by NHS surgeons who are se...2020-08-0933 minBig Picture MedicineBig Picture Medicine#023 BioBeats 🎶 — Dr David Plans (CEO BioBeats)How could better understanding your internal state improve your mental health? Dr David Plans is a lecturer in Organisational Neuroscience and CEO of BioBeats; a company on a mission to free people from mental suffering. He’s completing his second PhD in Experimental Psychology at the University of Oxford and has raised over $6M to turn his academic research into a bustling company. This is a really interesting conversation in which I’m completely out of my depth. We start by discussing David’s story and his view of hustle culture and how enhancing peoples’ interoce...2020-08-0626 minBig Picture MedicineBig Picture Medicine#022 The VR Surgeon 🥽 — Professor Shafi AhmedProfessor Shafi Ahmed is the world’s most watched surgeon.  He has live-streamed operations using Google Glass, the Snapchat Spectacles — and even virtual reality technology. He’s really at the cutting edge of surgical innovation so it was a real privilege to speak to him. He is the co-founder of Medical Realities; a company which specialises in surgical VR and AR tech. He has spoken at Wired Health, TEDx — he leads charity work in his native Bangladesh, he’s setting up a hospital of the future in Bolivia. He has consulted for Google, PwC, Roche...2020-08-0236 minBig Picture MedicineBig Picture Medicine#021 NHS Referrals are Broken — Dr Owain Hughes (CEO Cinapsis)How do you enact systems-level change within the NHS? Dr Owain Hughes was an ENT registrar before he decided to do something bold: fix NHS referrals. But systems-level solutions aren't as simple as just making an app... here's how Cinapsis did it. Find Dr Owain Hughes: Cinapsis: https://www.cinapsis.org Twitter: https://www.linkedin.com/in/owainrhyshughes You can find me on Twitter @MustafaSultan and subscribe to my newsletter on www.musty.io2020-07-3022 minBig Picture MedicineBig Picture Medicine#020 Deep Medicine 🚀 — Dr Eric TopolWhat would you be working on if you were a medical student today? Dr Eric Topol is in the top 10 most cited doctors in the history of Medicine. He is a cardiologist, geneticist and digital medicine expert — and was commissioned by the UK’s Health Secretary to write a report to prepare the NHS for the digital future: The Topol Review. Dr Topol has three best selling books on the future of Medicine: the Creative Destruction of Medicine, The Patient Will See you Now and Deep Medicine: How Artificial Intelligence Can Make Healthcare Human Again. This...2020-07-2630 minBig Picture MedicineBig Picture Medicine#019 Personal Branding and Forging Your Own Career Path — Dr James Somauroo (somX)How do you forge your own career path as a doctor? Dr James Somauroo is a former anaesthetics/ICU doctor and the founder of the healthtech agency: somX. He writes for Forbes and is also the host of the Health-tech podcast — the biggest podcast in this space with listeners in over 100 countries. Find Dr James Somauroo: LinkedIn: https://www.linkedin.com/in/james-somauroo/ The Health-tech Podcast: https://podcasts.apple.com/gb/podcast/the-health-tech-podcast/id1438968893 somX: https://somx.co.uk You can find me on Twitter @MustafaSultan and su...2020-07-2358 minBig Picture MedicineBig Picture Medicine#018 Babylon and the Business World — Dr Umang Patel (Director of NHS Services Babylon Health)How did a Paediatrician become the Managing Director of NHS Services at Babylon Health?  We talk about Umang's advice for medics entering the business world, how to keep your clinical job, Babylon's validation and some incredible advice on crafting your own story. —————— Find Dr Umang Patel: LinkedIn: https://www.linkedin.com/in/drumangpatel/ You can find me on Twitter @MustafaSultan and subscribe to my newsletter on www.musty.io2020-07-1943 minBig Picture MedicineBig Picture Medicine#017 The Effectivity Masterclass 💯 — Professor Neil SebireHow do you achieve peak performance as a medical student, doctor or clinical academic? Professor Neil Sebire works at the Great Ormond Street Hospital in London — the country's leading childrens' research hospital. He's published over 700 peer reviewed papers, has a h-index of 88 and 32,000+ citations. Here's everything he's learnt along the way. —————— Find Professor Sebire: LinkedIn: https://www.linkedin.com/in/neil-sebire-64780435/ You can find me on Twitter @MustafaSultan and subscribe to my newsletter on www.musty.io2020-07-1254 minBig Picture MedicineBig Picture Medicine#016 Medical Cannabis 101 — Dr Benjamin Viaris de Lesegno (CMO Cellen)Cellen is bringing medical cannabis to UK patients. I spoke to Dr Benjamin Viaris de Lesegno who is a French-trained NHS doctor as well as the co-founder and CMO of Cellen. The first half of this conversation covers the landscape of medical cannabis in the UK and its clinical need. We then talk about Benjamin's advice for fellow doctorpreneurs — and why 45 might be the best age to found your startup. Harvard Business Review article mentioned: https://hbr.org/2018/07/research-the-average-age-of-a-successful-startup-founder-is-45 —————— Find Benjamin: Cellen: https://www.cellenhealth.com LinkedIn: https://www.li...2020-06-2833 minBig Picture MedicineBig Picture Medicine#015 Medical Student Entrepreneurship — Dr Harvinder Power (CEO Motics)How do you run a successful startup and code academy — all whilst completing your final year at Imperial College Medical School? Harvinder Power is the co-founder and CEO of Motics — a company which brings physiotherapy into the digital era. He was the winner at the Kickstart Global Incubator, the McKinsey Venture Academy, the UCL VC Fund amongst many other accolades. In this conversation, I tease out the trials and tribulations of a medical student entrepreneur. We talk about how he started Motics, how you convince patients to do something they're not doing and what medics can...2020-06-2120 minBig Picture MedicineBig Picture Medicine#014 Ali Abdaal on Building a YouTube Empire, Personal Branding and Passive Income as a Medic — Dr Ali Abdaal®Ali has reached medic nirvana. He has over 770,000 YouTube subscribers, a successful business (6med), one of my favourite podcasts (Not Overthinking It) and is an all round wise man. He's managed to diversify so that Medicine is not his livelihood — it's a hobby he can approach on his own terms. His content started with advice for prospective and fledgling medical students — although he has now expanded into tech, productivity and entrepreneurship. You're going to love this episode if you're a wannabe creative, entrepreneur or want to get out of Medicine's rat race and play your own game. 2020-06-1452 minBig Picture MedicineBig Picture Medicine#013 Quit Genius: Medical Student to Y Combinator, 1 Million Users and Silicon Valley — Dr Sarim Siddiqui (Co-Founder Quit Genius)How do you convert an idea in medical school into a company that just raised $11M and has over 1 million users? Sarim, Yusuf and Maroof were three medical students at Imperial College London. They wanted to help people quit smoking  by delivering gold-standard addiction therapy digitally. Fast forward to today and they’ve expanded across the Atlantic and have over 1 million users, as well as becoming a multi addiction platform tackling smoking, alcohol and opioid addiction. We talk about Sarim's story, how to bring an idea into fruition and his advice for entrepreneurial med...2020-06-0635 minBig Picture MedicineBig Picture Medicine#012 Management Consulting for Medics, Digital Health and Why You Need a Performance Coach — Dr Charlotte Lee (UK Director Big Health)What's management consulting really like (all expensed trips to Vegas)!? How do you get your digital health solution into the NHS? And why do so many world-class performers have a performance/executive coach? This week's episode was a lot of fun, and you're going to love it if you want to hear advice from a super accomplished doctorpreneur. Dr Charlotte Lee is the UK director at Big Health, who generate $10M in revenue and are helping millions achieve good mental health — digitally. They have 12 RCTs under their belt, and are most famous for Sleepio, which digitally delivers CB...2020-05-3038 minBig Picture MedicineBig Picture Medicine#011 Validation over Valuation: An Oncologist's Battle Against Babylon Health — Dr David Watkins aka @DrMurphy11Isn't it strange when everyone is raving about something — but you just — don't get it? That's the position Dr David Watkins (@DrMurphy11) found himself in in 2017. Babylon had launched in the UK and promised to provide the powers of AI and telemedicine to the NHS. Babylon lets you video consult with a doctor, often on the same day. This was slightly controversial, but not compared to its other head. Babylon had developed a sophisticated chatbot AI. After a game of 20 questions, the chatbot would suggest a diagnosis — although crucially (from a regulatory point of view) it wou...2020-05-2317 minBig Picture MedicineBig Picture Medicine#010: Collaborating with DeepMind and How to Get into MedTech — Dr Pearse Keane (Moorfields Eye Hospital)How do you get into MedTech and collaborate with DeepMind/Google Health to lead world-renowned Deep Learning research? All to help stop people from going blind?  This is 30 minutes of pure gold — Dr Pearse Keane's advice on how to get into exciting Deep Learning projects, approaches that worked for him and books he recommends. Dr Pearse Keane is a consultant ophthalmologist and NIHR Clinician Scientist at Moorfields Eye Hospital in London. Pearse was responsible for starting the collaboration between Moorfields and DeepMind. Some of his most famous research uses deep learning to identify retinal disease fro...2020-05-1629 minBig Picture MedicineBig Picture Medicine#009 The First Brit in Space and the Peculiar Doctor-Astronaut Relationship — Helen Sharman OBEEver wondered if astronauts are honest with their doctors? Or what it feels like to look out of the window at Earth? Helen Sharman was the first British astronaut. Project Juno, was a joint Soviet-British programme which took Helen to the Mir Space Station. Helen was working as a research technologist for Mars (the confectionery company) before hearing about the opportunity on the radio. We talked about the selection and training, what it’s like being in Space and the peculiar doctor-astronaut relationship.2020-05-0927 minBig Picture MedicineBig Picture Medicine#008 Machine Learning for Medics 101 🤖 — Dr Chris Lovejoy (Doctor and Data Scientist )What’s AI? What’s machine learning? What’s deep learning? This week’s episode is a crash course on machine learning for medics. Dr Chris Lovejoy is a doctor, data scientist and content creator. He runs some exceptional ‘machine learning for medics’ day courses in London which is where I met him — and he also puts out loads of great content on his YouTube channel and newsletter. He also recently published a systematic review in the BMJ titled: AI Versus Clinicians: a Systematic Review. If you’re someone who has heard of concepts in AI and machine l...2020-05-0338 minBig Picture MedicineBig Picture Medicine#007 The Logistics of Buying PPE from China — Dr Alisa Pearlstone (NHS Hero Support)What are the realities of trying to procure PPE during a pandemic? As the government has given the NHS a 'blank cheque' to fight against COVID-19 — why can't we just throw money at the PPE shortage? To get answers, I spoke to Dr Alisa Pearlstone — the project director at NHS Hero Support — a pop up, emergency PPE delivery service. They’ve teamed up with the Doctors Association and Letsbeatcovid to help fight the PPE shortage. You can donate to NHS Hero Support at www.nhsherosupport.co.uk Links to socials and the podcast newslett...2020-04-2615 minBig Picture MedicineBig Picture Medicine#006 Scuba Masks and PPE 🤿 — Mr Ryan Kerstein (Oxford Inspired)What do you when hospitals are running out of Personal Protective Equipment (PPE) and your colleagues are at risk? Ryan and his team at Oxford Inspired have created a PPE mask out of scuba masks. They plan to deliver 3000 of these to the frontlines — but how do they work? And why are they having to step in? You can donate to the fundraiser at: www.oxford-inspired.com and you can find Ryan's innovation journal of the future at www.weshare.healthcare More about reverse innovation: https://www.bmj.com/content/367/bmj.l6205 ...2020-04-1819 minBig Picture MedicineBig Picture Medicine#005 Prediction Models for Diagnosis and Prognosis of COVID-19 (BMJ Paper) — Professor Laure Wynants (Maastricht University)"I'm going to go out on a limb and say that AI isn't going to get us out of the covid-19 crisis." Natasha Loder, Health Policy Editor at the Economist. Except, some researchers are trying just that. They're using deep learning to read CT scans and try to diagnose COVID-19, as well as building other types of models to predict the prognosis (mortality, length of hospital stay etc.) of the disease. A number of these models have been published as preprints or in academic journals — but Laure's team found that they were poorly reported, at a...2020-04-1015 minBig Picture MedicineBig Picture Medicine#004 Predicting the Future of COVID-19 Using Epidemiological Models — Dr James Hay (Computational Epidemiologist at Harvard School of Public Health)Curious about how the UK made the decision to the lock the country down? It was made using epidemiological models. One research team has been particularly influential in their response — the Imperial College team led by Professor Neil Ferguson. Their model predicted that an unchecked COVID-19 epidemic would overwhelm the NHS and result in 500,000 UK deaths. They suggested that we may need to have some form of social distancing for 12 out of the next 18 months. More recently, an Oxford University team led by Professor Sunetra Gupta published their own model. Any model on covid-19 has to make so...2020-04-0115 minBig Picture MedicineBig Picture Medicine#003 AlzEye, Deep Fakes and the Eye as a Window Into the Soul — Dr Siegfried Wagner (Moorfields Eye Hospital)What can 2 million retinal images and a machine-learning algorithm achieve? Early-detection of Alzheimers—at least that's what Dr Siegfried Wagner along with a team led by Dr Pearse Keane at the Moorfields Eye Hospital are working towards.  We discuss the study at Moorfields, before going down a deep dive into how a relatively novel AI technique—Generative Adversarial Networks (GANs) can be used in Medicine. You may have seen a number of 'deep fakes' online, all made using GANs. But what legitimate uses do they have in Medicine and research?  Mentioned Links AlzEye Study...2020-03-1522 minBig Picture MedicineBig Picture Medicine#002 AI in Paediatrics and Pathology — Professor Neil Sebire (Chief Research Information Officer at GOSH)A professor of Pathology who has accepted his impending redundancy from AI image recognition—Professor Neil Sebire is also the Chief Research Information Officer at Great Ormond Street Hospital (GOSH); the country's leading children's research hospital. We talk about the future of pathology and paediatrics in the context of AI, how he partnered with Microsoft to create the GOSH in Minecraft and I finish off by asking him for his advice on academic success and getting published. 2020-03-0431 minBig Picture MedicineBig Picture Medicine#001 Blockchain and What Doctors Should Know About It — Dr Abdullah Albeyatti (CEO MedicalChain)Blockchain (the technology behind Bitcoin) can be difficult to understand. It's been surrounded by cultish hype and it's not immediately obvious how it relates to healthcare. In this episode, Dr Abdullah Albeyatti gives an 'Explain-Like-I'm-Five-Years-Old' explanation of blockchain and covers how it can be used to manage patient records, in clinical trials and even on the organ donation registry.  He explains his journey from a doctor with an idea, to CEO and cofounder of MedicalChain; an electronic health record system which uses BlockChain technology to put the patient in control of their medical data. It's a fascinating s...2020-02-2449 min