Shows
Personalized Medicine PodcastEp#47: Podcast FinaleDear listeners,This is a bittersweet moment for us. With this episode, we conclude the Personalized Medicine Podcast series. We would like to thank all of you for staying with us over the last 3 years! This has been an amazing ride and we appreciate your constant support and feedback. We hope you enjoyed listening to this show as much as we enjoyed making it for you.In this final episode, our team sits down once more to remember how it all started and how the team came together over these years. We share o...2022-12-2927 min
Personalized Medicine PodcastEp#46: Improving Healthy Longevity via Transcription Factors with Dr. Victor BustosIn this episode of the Personalized Medicine Podcast we sat down with Dr. Victor Bustos, the co-founder and COO of Refoxy Pharma, a pharmaceutical company focused on new therapies for age-related diseases.Victor is a molecular biologist by training and dedicated his research career to understanding the biology of aging. In this interview, we discuss the role of FOXO transcription factors in regulating lifespan, Victor's transition from academia to the world of biotech start-ups and his progress with Refoxy Pharma.2022-12-1431 min
Personalized Medicine PodcastEp#45: Applying DNA Nanostructures to Personalized Medicine with Dr. Ali Aghebat RafatWelcome to the next episode of the Personalized Medicine Podcast. In this episode, our host Aradhana sat down for a conversation with Dr Ali Aghebat Rafat, Scientist at Tilibit Nanosystems. Aradhana and Ali discussed DNA nanostructures, DNA self-assembly, barcoding, biochips and their potential applications in Personalized Medicine.Tune in to this episode to learn more about: ◦ Tilibit Nanosystems and their mission ◦ Application areas of DNA origami in diagnostics ◦ What is DNA Paint ◦ A day in a life of a start-up scientist ◦ Role of nucleic acid nanostructures...2022-07-2738 min
Personalized Medicine PodcastEp#044: Applying Nanoparticles and Microfluidics to Personalized Medicine with Martin RabelWelcome to the next episode of the Personalized Medicine Podcast. In this episode, our host Aradhana talked to Martin Rabel, the Field Application Scientist at Precision Nanosystems, about nanoparticles, microfluidics, gene delivery in the context of personalized medicine.Tune in to this episode to learn more about: ◦ Precision Nanosystems and their mission ◦ Role of nanoparticles and microfluidics in Personalized Medicine ◦ Next-Gen microfluidics technologies ◦ Application of nanoparticles in pharmaceutical applications ◦ Challenges in developing RNA-based lipid nanoparticles ◦ Role of regulatory bodies in implementation of personalized medicine approaches ◦ The outlook on the future of personalized m...2022-06-2948 min
Personalized Medicine PodcastEp#043: Developing Precision Medicines Using Cryo-EM with Dr. Sriram SubramaniamIn this episode we dive deep into the world of structural biology. We discuss the role of cryogenic electron microscopy in the development of precision medicines with the founder and CEO of Gandeeva Therapeutics, Dr. Sriram Subramaniam. Cryo-EM opened a new way to study drug-target interactions and is changing the way we develop new therapies.Tune into our interview with Sriram to learn more about: ◦ The founding story of Gandeeva Therapeutics ◦ The evolution of Cryo-EM technology ◦ Application of Cryo-EM in drug discovery ◦ Advantages of Cryo-EM over crystallography im mapping protein structures ◦ Making sense of experim...2022-06-1643 min
Personalized Medicine PodcastEp#042: Applying Epigenetics to Personalized Skincare with Dr. Shakiba Kaveh and Dr. Cristiana BanilaIn this next podcast episode we dive into a topic of personalized skincare. Our host Oleksandr is joined by the co-founders of Mitra Bio, Dr. Shakiba Kaveh and Dr. Cristiana Banila. Pharmaceutical and personal care companies have been trying to unlock personalized skincare for decades. Shakiba and Cristiana bring a special key to the table, and it is epigenetics. Tune in into our interview to learn more about: ◦ The founding story of Mitra Bio ◦ The role of genetic and epigenetic factors in skin health ◦ Cracking epigenetic code ◦ Role of reliable models in understa...2022-05-1832 min
Personalized Medicine PodcastEp#041: Exploring Microgravity for Life Science with Daniela BezdanWelcome to the next episode of the Personalized Medicine Podcast. In this episode, we have talked about a variety of topics ranging from exploring space and microgravity for applications in biotechnology and physical science to developing pathogen detection systems. Our guest today is Dr. Daniela Bezdan, the Chief Scientific Officer of Yuri Gravity and co-founder of Poppy. Daniela is also the co-chair at several space-associated organizations such as ISSOP (International Space Standards Operation Procedure) and NASA GeneLabs that foster international cooperation, and support educational citizen science projects. Together with Daniela we discussed: ◦ Evolution of microgravity in...2022-04-2735 min
Personalized Medicine PodcastEp#040: Eliminating Cancer Using Invariant Natural Killer T Cells (iNKTs) with Dr. Jennifer BuellWelcome to the next episode of the Personalized Medicine Podcast. On this podcast we have talked extensively about antibody, vaccine and CAR-T cell based approaches to treat cancer. Today we will be talking about a new approach in oncology that is based on invariant Natural Killer T Cells, or iNKTs. Our guest today is Dr. Jennifer Buell, the founder, CEO and President of MiNK Therapeutics and the former President and COO of Agenus. Jennifer has over 25 years of experience in the biopharmaceutical space, having held multiple leadership positions at biotech companies. In her tenure at Agenus, she transformed...2022-04-0753 min
Personalized Medicine PodcastEp#040: Eliminating Cancer Using Invariant Natural Killer T Cells (iNKTs) with Dr. Jennifer BuellWelcome to the next episode of the Personalized Medicine Podcast. On this podcast we have talked extensively about antibody, vaccine and CAR-T cell based approaches to treat cancer. Today we will be talking about a new approach in oncology that is based on invariant Natural Killer T Cells, or iNKTs. Our guest today is Dr. Jennifer Buell, the founder, CEO and President of MiNK Therapeutics and the former President and COO of Agenus. Jennifer has over 25 years of experience in the biopharmaceutical space, having held multiple leadership positions at biotech companies. In her tenure at Agenus, she transformed...2022-04-0750 min
Personalized Medicine PodcastEp#039: Using Protein Degraders to Treat Neurodegenerative Diseases with Dr. Beth HoffmanIn this episode we dive deep again into the topic of protein degradation and how it can be leveraged to treat neurodegenerative diseases. Our guest today is Dr. Beth Hoffman, the founder, CEO and President to Origami Therapeutics. Beth's career is a showcase of remarkable success in the biotech industry. She spent almost 25 years working in CNS drug discovery and was involved in the development of over 30 therapeutic molecules. Most notably she led the discovery and development of a few first-in-class blockbuster drugs for cystic fibrosis at Vertex Pharmaceuticals. Her most recent venture, Origami Therapeutics, is focusing on developing protein...2022-03-1634 min
Personalized Medicine PodcastSpecial Episode: UkraineThank you very much for tuning into this special episode of the Personalized Medicine Podcast. Some of you might know that our founder and host Oleksandr (a.k.a. Sasha) is Ukrainian. In this difficult moment for his country, Sasha shares his thoughts on current situation in Ukraine and explains how anyone in the world can help and support people of Ukraine and its scientific community.Out team has prepared a list of trusted organizations and charitable foundations supporting Ukraine at the moment:Support Ukrainian military (Official Bank Account of Ukrainian Ministry of Defense): https://bit...2022-03-0805 min
Personalized Medicine PodcastEp#038: Unleashing the full power of CAR-T cells with Dr. Eric von HofeIn this episode we are returning to a very exciting topic of immunooncology and we will talk in detail about novel approaches to treat cancer, based on CAR-T cell technology.Please welcome Dr. Eric von Hofe, the Senior Advisor and former President of Affyimmune Therapeutics. Eric’s story is a showcase of a remarkable career in the biotech industry. Eric studied Biology at UC Berkeley and received his PhD from the University of Southern California. HEric continued his career in cancer research doing two PostDocs at ETH Zurich and Harvard and then taking a position of Assistant Professor at...2022-02-2334 min
Personalized Medicine PodcastEp#037: Making Personalized Medicine Available to Every Patient with Christopher WellsWelcome to the next episode of the Personalized Medicine Podcast. On this show we typically talk about science and technology driving the progress in personalized medicine. But the policy side of things and patient access are equally important.We are happy to welcome on our podcast Christopher Wells, the Vice President of Public Affairs at the Personalized Medicine Coalition. Chris has recently published an article in STAT in which he eloquently described why we cannot narrow down personalized medicine just to cancer and need to look at it through a larger lens. And this is what we have...2022-02-0232 min
Personalized Medicine PodcastEp#036: Tackling Sepsis Using Next Generation Sequencing with Dr. Philip StevensWelcome to Season 3 of the Personalized Medicine Podcast! We hope you all head a good start in 2022 and are ready to dive deep into the world of personalized medicine with us again.In this first episode of Season 3, we address a very important and, frankly speaking, underappreciated topic of sepsis, commonly known as bacterial blood poisoning. Did you know that last year, sepsis killed more people than 5 most common types of cancer combined? For this episode, our host Oleksandr Yagensky sat down with the co-founder and CEO of Noscendo, Dr. Philip Stevens. Philip and his team...2022-01-1234 min
Personalized Medicine Podcast2021 in Personalized Medicine: Crossover Episode with the Host of the Genetics Podcast, Dr. Patrick ShortWelcome to the final episode of 2021! This one was long in the making. We are happy to present the crossover episode between the Genetics Podcast and the Personalized Medicine Podcast. In this episode our host Oleksandr (Sasha) Yagensky wraps up 2021 with one and only Patrick Short, the CEO of Sano Genetics and host of the Genetics Podcast. Listen to Patrick and Sasha as they share their 2021 highlights from the world of Personalized Medicine.Together with Patrick we focused on 6 highlights in 2021: ◦ Large scale liquid biopsy trial for presymptomatic cancer detection ◦ Whole genome sequencing making its entry into...2021-12-1957 min
The Genetics PodcastEP 74: Biggest breakthroughs of 2021 with Personalized Medicine Podcast host, Oleksandr YagenskyIn the last episode of the year, Patrick joins forces with the host of the Personalized Medicine Podcast, Oleksandr Yagensky, to discuss six of the biggest and most exciting breakthroughs in genetics research in 2021. They talk about developments including cancer testing in healthy people, newborn genetic screening, AI and machine learning, stem cells, and more.2021-12-194h 40
Personalized Medicine PodcastEp#034: Reversing Aging with Daniel OliverIn this episode of the Personalized Medicine Podcast we are returning to the topic of aging. It is our pleasure to introduce to you the co-founder & CEO of Rejuvenate Bio, Daniel Oliver. Dan studied Mechanical Engineering & Business at Caltech and obtained an MBA from Harvard Business School. After completing his studies, Dan has co-founded several successful companies in very diverse industries. With Rejuvenate Bio Dan and his co-founder Noah Davidsohn are developing new gene therapies to address aging and age-related diseases.In our conversation with Dan we discussed: ◦ The founding story of Rejuvenate Bio ◦ Role of sere...2021-12-1532 min
Personalized Medicine PodcastEp#033: Decoding Liver Diseases with Jack O'Meara and Dr. Quin WillsThis is officially one of the most fun episodes of the Personalized Medicine Podcast. This time we sat down not just with one, but with two amazing guests. Please welcome the co-founders of Ochre Bio, Jack O’Meara and Quin Wills. Together we talked about livers, drug development for metabolic diseases and biotech entrepreneurship. This episode is full of funny anecdotes, contrarian ideas and inspirational thoughts. Give it a listen!Together with Jack and Quin we discussed: ◦ Mission of Ochre Bio ◦ Taking a biotech startup off the ground ◦ Differences in building a biotech companies in the US v...2021-11-2440 min
Personalized Medicine PodcastEp#032: Developing Oncolytic Viruses to Fight Cancer with Arthur KuanIn this episode we are focusing on cancer, oncolytic viruses and how investor mindset helps building successful biotech companies. Our guest today is Arthur Kuan, the CEO of CG Oncology. Arthur is a molecular biologist by training. After completing his undergraduate training, Arthur started his career as a venture investor working at several prominent Shanghai-based funds focusing on the Healthcare industry. In 2016, Arthur became the CEO of CG Oncology, one of the portfolio companies of Ally Bridge, the investment fund he was working at the time. In this interview, Arhtur shares his story of becoming a CEO and explains the...2021-11-0335 min
Personalized Medicine PodcastEp#031: Advancing Precision Oncology with Dr. Gang SongIn this episode of the Personalized Medicine Podcast we talk about precision oncology with a scientist and serial entrepreneur, Dr. Gang Song. Gang completed his PhD degree in Biochemistry and Molecular Biology at the Shanghai Medical College of Fudan University and then moved to Harvard where he did a PostDoc at the lab of Tim Springer where he was studying structure and function of cell adhesion molecules. Gang has extensive experience in the life science industry working at various positions at IQuum, which was acquired by Roche, Genzyme Genetics and LabCorp. In 2014, Gang founded Pillar Biosciences, a precision medicine company...2021-10-1337 min
Personalized Medicine PodcastEp#030: Using iPSCs to Discover New Therapies for Neurodegenerative Disorders with Professor Evangelos KiskinisOn this episode we take a look at the role induced Pluripotent Stem Cells (iPSCs) are playing in drug discovery and development for neurodegenerative diseases. Our host Oleksandr sat down with Professor Evangelos Kiskinis, who is leading his own research group at the Northwestern University in Chicago. Evangelos and his team are leading the way on the development of novel cell-based models for ALS, epilepsy and other types of neurological conditions.Check out this episode to learn more about:◦ Evangelos’s career story and what got him excited in stem cell research◦ Challenges in modeling neurodegenerative diseas...2021-09-0139 min
Personalized Medicine PodcastEp#029: Unleashing the Power of a Non-Coding Genome with Dr. Samir OunzainIn this episode, we are diving deep into the world of the non-coding genome and, more specifically, an exciting new class of biomolecules - the long non-coding RNAs (lncRNA). Welcome, Dr. Samir Ounzain, the co-founder and CEO of HAYA Therapeutics. Samir and his startup HAYA are developing first-in-class therapies to target lncRNA responsible for the manifestation of various diseases. Samir and HAYA are aiming at fibrosis first, but have in mind a plethora of other conditions that can be treated by their approach. Join us for an insightful conversation on the non-coding genome, the journey from basic science to entrepreneurship...2021-08-1137 min
Personalized Medicine PodcastEp#028: Applying Laser Physics to Enable Personalized Stem Cell Therapies with Dr. Nabiha SaklayenIn this Podcast episode we return to the topic of stem cells. We discussed that autologous stem cells can be a powerful therapeutic tool for Parkinson’s disease in our interview with Professor Jeanne Loring. The challenge however is to manufacture those therapies at scale. Our guest on this episode is taking a major step in alleviating this hurdle. Meet Nabiha Saklayen, the co-founder and CEO of Cellino, a company that merges stem cell biology, laser physics and machine learning to make autologous stem cell therapies possible. Together with Nabiha, we discussed:◦ Her personal career story from phys...2021-07-2145 min
Personalized Medicine PodcastEp#027: Finding the Best Possible Treatment for Each Cancer Patient with Dr. Dan RhodesThis Podcast episode cannot get any closer to what personalized medicine is really about. Welcome Dr. Dan Rhodes, the founder and CEO of Strata Oncology, a leading precision oncology company leveraging state-of-the art genomics tools for more efficient cancer diagnostics and treatment. Dan is a bioinformatician by training and spent his entire career applying genomics to solving complex problems in oncology. Dan founded two very successful startups in this field and also has gathered vast experience working as a VP of Oncology Strategy at large corporations (Life Technologies and Thermo Fisher). This interview is full of deep insights on the...2021-06-1648 min
Personalized Medicine PodcastEp#026: Bringing Protein Biomarkers Closer to Clinics with Dr. Sophia DollIn this episode, we return to our beloved field of proteomics. This time we focus on answering a question on how automation and AI can improve biomarker discovery and ultimately benefit patients. Our guest is Dr. Sophia Doll, co-founder of OmicEra Diagnostics, one of the most exciting startups in the field of proteomics today.Sophia did her Ph.D. at the Max Planck Institute for Biochemistry in Munich where she studied translational protein biomarkers of cancer in the lab of Mathias Mann. She conducted part of her graduate research at the University of California in San Francisco and...2021-04-2134 min
Personalized Medicine PodcastEp#025: Leveraging Real World Data for Effective Treatment of Multiple Sclerosis with Dr. Richard RudickIn this episode we talk about multiple sclerosis (MS) and the role personalized medicine and real world data (RWD) are playing in treating this disease effectively. To discuss this topic, we sat down with one of the leading experts in this field - Dr. Rick Rudick. Rick is a neurologist by training and has more than 25 years of experience at Cleveland Clinic where he developed and directed the Mellen Center for Multiple Sclerosis. Rick was also a Vice President of pharmaceutical company Biogen, where he developed the Multiple Sclerosis Innovation Hub and was involved in establishing international Multiple Sclerosis Partners...2021-03-3152 min
Personalized Medicine PodcastEp#024: Moving the Lab to a Cloud with Toby BlackburnScientists today still spend an enormous amount of time on physical labor: pipetting, feeding cells, taking microscope images and performing all kinds of other experiments manually. That leaves researchers with a very limited time to do their core activities such as reading, talking to their colleagues and coming up with new hypotheses. Our guest on this episode is coming from an organization that is aiming to change that. Welcome on the show Toby Blackburn, the Head of Business Development and Strategy at Emerald Cloud Lab (ECL). ECL has built a lab that can be accessed virtually by any scientist from...2021-03-1726 min
Personalized Medicine PodcastEp#023: Applying Bioinformatics to Design Therapeutics of the Future with Dr. John CastleIn this episode of the Personalized Medicine Podcast, we sat down with the guru of bioinformatics, Dr. John Castle. John is a physicist by training who found a passion for answering complex questions in drug development using a data-driven approach. He led bioinformatics teams at multiple successful companies including Rosetta Inpharmatics, Merck and Agenus. John was also employee number 5 at BioNTech, a company best known for its development of the first approved COVID vaccine. While at BioNTech John established and led the Computational Medicine team that was focusing on anti-cancer mRNA-based vaccines. Currently, John is a Chief Data Scientist Officer...2021-02-2454 min
Personalized Medicine PodcastEp#022: Using Smartphones to Monitor Women's Health with Dr. Leo MartinezIn this episode, our host Aradhana Chopra sat down with Leo Martinez, one of the co-founders of Colorimetrix, the mobile health tech company behind the Pearl Fertility app. It is the first App to be approved as a medical device to monitor and chart all-important hormones of the menstrual cycle at home and help women with their fertility decisions. Dr. Martinez shares his experiences of founding Colorimetrix, developing the algorithms, using the technology in the pearl fertility app, and finally getting permissions and approvals for its release in the markets.Together with Leo, we discussed: ° Smartphones as p...2021-02-1037 min
Personalized Medicine PodcastEp#021: Treating Parkinson's Disease Using Patient's Own Stem Cells with Professor Jeanne LoringWelcome to the first episode of the Personalized Medicine Podcast in 2021. And what a guest do we have to kick-off this year!In this episode, we dive deep into the world of stem cells with one of the most influential scientists in the field, Professor Jeanne Loring. Jeanne is a Professor Emeritus and a Director of the Center for Regenerative Medicine at Scripps Research. She made pivotal contributions to the field of stem cell research publishing 120+ papers on the topic. Jeanne is also a true veteran of the biotech industry working for some of the most important companies...2021-01-1353 min
Personalized Medicine PodcastEp#020: Ultrapure DNA as a Novel Therapeutic Class with Dr. Cosimo DucaniIn Episode 3 of Season 2 of the Personalized Medicine Podcast, our new host, Aradhana Chopra, sat down with Dr. Cosimo Ducani. Cosimo is the founder and CEO of Moligo Technologies, a Biotech start-up from Sweden that aims at providing alternative and improved enzymatic nucleic acid synthesis methods at the industrial scale. Cosimo talks about the increasing demand and need for long and ultra-pure DNA strands in diagnostics and therapeutics and explains oportunities and challenges young biotech start-ups are facing on their journey to success.Together with Cosimo we talk about: ◦ What inspired Cosimo to start his own co...2020-11-2523 min
Personalized Medicine PodcastEp#019: Uncovering Genetic Risk Factors of Neurological Disorders with Professor Naomi WrayThe next episode of the Personalized Medicine Podcast is out! In this episode we take a look at the role of genetic factors in the development of neurological disorders. Our host Oleksandr Yagensky sat down with one of the gurus of the field, Prof. Naomi Wray. Naomi holds joint appointments at the Institute for Molecular Bioscience (IMB) and the Queensland Brain Institute (QBI) within the University of Queensland. She has published around 300 papers on the intersection of neurobiology, genetics and bioinformatics and contributed greatly to our understanding of genetic causes of schizophrenia, depression and many other neurological disorders....2020-11-1134 min
Personalized Medicine PodcastEp#018: Bringing Proteomics One Step Closer to Clinics with Dr. Oliver RinnerWe are back! The first episode of Season 2 of the Personalized Medicine Podcast is out! In this episode, our host Oleksandr Yagensky sat down with Dr. Oliver Rinner, co-founder, and CEO of Biognosys, a proteomics technology company. We discussed the growing role of proteomics in healthcare, its impact on biomarker discovery, and the development of new therapeutics. Together with Oliver, we talk about: ◦ Startup story of Biognosys ◦ Transitioning from academia to entrepreneurship ◦ Impact of proteomics on pharma industry ◦ Role of proteomics in biomarker discovery ◦ Differences between targeted and discovery mass spectrometry ◦ Ro...2020-10-2843 min
Personalized Medicine PodcastEp#017: Lessons Learned from the 16 Innovators in Personalized MedicineWelcome to the final episode of Season 1 of the Personalized Medicine Podcast!In this episode we look back at the past 9 months, share our own story and remember the most exciting moments of season 1. Our entire team has joined for the recording to share and discuss what we have learned from our guests. We have covered a broad range of topics spanning from genomics to artificial intelligence to privacy-by-design. As we look back, we tie in the insights we have gained from each and every speaker we had a privilege to welcome on our show.Together...2020-08-051h 03
Personalized Medicine PodcastEp#016: Ensuring Fairness in Precision Medicine with Dr. Kadija FerrymanPrecision medicine has the potential to transform healthcare in terms of diagnostics, treatment, and prevention of disease. But what does a future with a more personalized approach to medicine look like? Who will ultimately benefit from precision medicine?In this episode, we dive into these questions with Dr. Kadija Ferryman, a cultural anthropologist whose research centers on the ethical dimensions of health risk technologies, especially as they relate to racial disparities in health. Kadija is an Industry Assistant Professor at NYU’s Tandon School of Engineering. She is also an affiliate at the Data & Society Research Institute, where sh...2020-07-1553 min
Personalized Medicine PodcastEp#015: Enabling Personalized Medicine through Biomarkers of Response with Dr. Liz O'DayIn episode 15, our host Oleksandr Yagensky sat down with Dr. Liz O’Day, the founder and CEO of Olaris, a biotech company that enables patients to pursue most effective personalized treatments. Liz unravels how small molecule metabolites along with machine learning can be utilized to evaluate patient-specific responses to therapeutics. Together with Olaris, Liz is shaping the future of personalized medicine. Just two weeks ago, she was elected to the Board of Directors at Personalized Medicine Coalition in recognition of her contribution to the field.Together with Liz, we discussed: ◦ The startup story of Olar...2020-07-0153 min
Personalized Medicine PodcastEp#014: Applying Glycobiology to Fight Coronavirus with Dr. Parastoo AzadiRecently glycans have been receiving a lot of attention. It turns out, the surface of coronavirus is packed with glycans, which help this virus evade our immune system.In this episode, we interviewed Dr. Parastoo Azadi, whose recent research sheds light on the structure of coronavirus core surface glycoprotein, and hence can facilitate the development of a vaccine against it.Together with Parastoo, we have discussed: ◦ Role of glycans in coronavirus infection ◦ Challenges in developing an effective vaccine against SARS-COV-2 ◦ Significance of glycobiology in the biotech industry ◦ Evolution of Mass Spectrometry ◦...2020-06-1741 min
Personalized Medicine PodcastEp#013: Preventing Adverse Drug Reactions through Pharmacogenomics with Amani SainiIn thirteen episode of the Personalized Medicine Podcast we focus on the personalization oftreatment in clinical practice. There is mourning evidence that shows that variations in thegenome can significantly affect inter-patient differences in drug response. Together with AmaniSaini, the founder of Adverse Drug Reaction (ADR) Canada, we talk about the field ofpharmacogenomics, adverse drug reactions and the future of tailored therapy. Amani holds aBA in Political Science from the University of British Columbia and Master of PublicAdministration degree from Dalhousie University. She currently serves as president of ADR2020-06-0344 min
Personalized Medicine PodcastEp#012: Personalization in Reproductive Medicine in the Era of CRISPR/Cas9 with Dr. Helen O'NeillIn Episode 12, we discuss the progress of personalization in the field of reproductive medicine with our guest Dr. Helen O'Neill. Helen is a Lecturer in Reproductive and Molecular Genetics and Director for the MSc Program in Reproductive Science and Women’s Health at the Institute for Women’s Health, University College London. She has over 10 years of experience as a researcher and science communicator on various topics of reproductive medicine, genome editing, and women’s health. Beyond her work as an academic, she recently co-founded Hertility Health with the aim to change the face of women’s health.Our host...2020-05-2040 min
Personalized Medicine PodcastEp#011: From Whole Genome Sequencing to a Genome in Your Pocket with Dr. Mark HahnelIn Episode 11 of the Personalized Medicine Podcast our host Oleksandr Yagensky discussed the topic of genetic data management with Dr. Mark Hahnel. Mark is the co-founder of Genomes.io, a personalized DNA databank that gives consumers ultimate control of their genome data. He is also CEO and founder of Figshare, repository for published and unpublished scientific data of all formats.Together with Mark, we discussed: ◦ The importance of open access in research acceleration ◦ A new approach Genomes.io is applying to consumer genomics ◦ Role of blockchain in DNA data security ◦ How consumers can mone...2020-05-0642 min
Personalized Medicine PodcastEp#010: Digital Health in Rwanda - From Telemedicine to the integration of AI with Dr. Patrick SingaIn the tenth episode of the Personalized Medicine Podcast, we talk about digital health technology in Rwanda. Our host Luisa Hallmaier-Wacker talks to Dr. Patrick Singa, the medical director babyl, about telehealth and the integration of AI into clinical diagnostics. Babylon Health, which is based in the UK, launched babyl in 2016 in Rwanda and established a comprehensive fully integrated mobile healthcare service. With over 2 million registered users and over 3,500 consultations a day, babyl has been very successful to date and is currently working on integrating AI technology into clinical diagnostics. Patrick has been involved with babyl since its inception. He...2020-04-2245 min
Personalized Medicine PodcastEp#009: Cell-free DNA as a Precise Diagnostic Marker of Infectious Diseases with Dr. Tim BlauwkampIn episode 9 we dive deep into the topic that could not be more relevant today - diagnosis of infectious diseases. Our guest on this episode is Tim Blauwkamp, the co-founder and Chief Scientific Officer of Karius, a company that leverages genomics and AI to develop highly-accurate diagnostic tests based on cell-free DNA sequencing. Karius has recently raised a stunning Series B round of $165 million to further the transition of their test to clinic.Tim did his PhD in Biochemistry at the University of Michigan, where he studied genes involved in nitrogen assimilation in bacteria. He then continued as a Po...2020-04-0852 min
Personalized Medicine PodcastEp#008: Leveraging AI for Personalized Treatment of Depression with Dr Maryna PolyakovaIn the eighth episode of the Personalized Medicine Podcast we discuss the role of AI in psychiatric treatments with Dr. Maryna Polyakova. Maryna is a medical doctor by training and a scientist who recieved her PhD from the Max Planck Institute for Human Cognitive and Brain Sciences in Leipzig. She is also the CEO and co-founder of AccuBio, a company that enables personalized treatments for depression leveraging AI approaches.Together with Maryna we discussed: ◦ The heterogeneity of depression ◦ Investigation of blood biomarkers for depression ◦ Integration of clinical neuroimaging, proteomic and genomic data ◦ Switching from res...2020-03-2536 min
Personalized Medicine PodcastEp#007: Privacy Protection in the Age of Personalized Medicine with Dr Rachele Hendriks-SturrupIn episode 7 we are addressing a topic that is important in many areas of personalized medicine– data privacy protection, together with Dr. Rachele Hendricks-Sturrup. Rachele is a prominentacademic in the field of consumer privacy and currently serves as a Health Policy Counsel at theFuture of Privacy Forum. The Future of Privacy Forum is a nonprofit organization that aims toexplore the challenges posed by technological innovation and develop privacy protections,ethical norms, and workable business practices together with industry, academics, consumeradvocates, and other thought leaders. The organization ‘fills the void in the...2020-03-0449 min
Personalized Medicine PodcastEp#006: Immuno Oncology – Training Immune System to Fight Cancer with Dr Stefaan Van GoolIn episode 6 we are addressing one of the hottest topics in modern medicine – Immuno Oncology, together with Dr. Stefaan van Gool. Stefaan is a Medical Director of Translational Oncology at the Immunooncological Clinical Center in Cologne, Germany. IOZK is one of the most advanced institutions of this kind in the country. Stefaan has more than 25 years of experience in clinical oncology and related basic research. He has co-authored more than 150 research papers on the relationship between the immune system and cancer.Together with Stefaan we have discussed:◦ The rise of Immuno Oncology◦ How to activate patien...2020-02-1259 min
Personalized Medicine PodcastEp#005: How Digitalization is Changing Healthcare with Professor David MatusiewitczIn the episode 5 we dive deep into the topic of digitalization in personalized healthcare. A lot has been going on in this space lately, especially in Germany. Therefore we are delighted to talk to one of the key opinion leaders on this topic, Professor David Matusiewicz. David is a professor of Healthcare Management at the FOM University for Applied Sciences and is a founding director of the Research Institute for Healthcare Management in Essen, Germany. He co-authored several books on the topics of digitalization and management in healthcare. David is also actively supporting medical startups as an angel investor and...2020-01-2230 min
Personalized Medicine PodcastEp#004: Improving Patient Recruitment for Clinical Trials with Christian ErbOn the fourth episode of the Personalized Medicine Podcast we switch gears from biomarker research to clinical trials with Christian Erb. Christian is a co-founder and CEO of Mondosano, a Hamburg-based company that addresses the bottleneck for a successful clinical trial – patient recruitment. Listen to our discussion with Christian to learn more about:◦ The story behind the founding of Mondosano ◦ Why clinical trials do not have good reputation among patients◦ Why patient education is the key to improve patient recruitment◦ Patient journey to and through a clinical trial ◦ How Mondosano helps pharma companies and study si...2020-01-0941 min
Personalized Medicine PodcastEp#003: Glycans - the Undervalued Biomarkers of Human Health and Disease with Prof. Gordan LaucIn the third episode of the Personalized Medicine Podcast we discuss glycans and their role in personalized medicine with Professor Gordan Lauc. Gordan is a Professor of Biochemistry and Molecular Biology at the University of Zagreb. He is also a Founder and CEO of Genos, one of the few companies in the world capable of high-throughput glycan analysis. In addition to it, Gordan has initiated the Human Glycome Project to facilitate collaboration between laboratories around the world and to encourage more scientists to include glycan analysis in their research. Together with Gordan we have discussed:◦ Why mo...2019-12-1640 min
Personalized Medicine PodcastEp#002: Making Sense of Genomic Data with Dr. Rocío Acuña HidalgoIn the second episode of the Personalized Medicine Podcast we dive into the world of genomics with Dr. Rocío Acuña Hidalgo. Rocío is a Chief Technology Officer at Nostos Genomics, a Berlin-based company that develops AI tools to diagnose patients with genetic diseases.Tune into this episode to learn more about:•The role of the Human Genome Project in our understanding of human genes •Impact of the Next Generation Sequencing on genomics •Are rare diseases really rare?•Big data problem in genomics•How machine learning can be leveraged to extract maximum clini...2019-12-0439 min
Personalized Medicine PodcastEp#001: How the Discovery of New Protein Biomarkers Can Improve Diagnostics with Prof. Kevin MillsIn this episode we discuss the importance of protein biomarkers in clinical diagnostics with Professor Kevin Mills. Kevin is a head of Translational Mass Spectrometry Research Group at University College London and co-authored more than 150 publications in the field of biomarker research. His test for the diagnosis of Fabry disease is used today to screen millions of patients worldwide. Tune into this episode to learn more about:•The evolution of biomarker research•Kevin's test to diagnose Fabry disease•Challenges in translating prospective biomarkers from research to clinics•The role of mass spectrometry in biomarke...2019-11-1846 min