Shows
Decoding LongevityInflammaging, the Immune System, and the Hidden Biology of Aging — A Conversation with Alan Landay, Ph.D.In this episode of Decoding Longevity, host Raghav Sehgal and co-host Macsue Jacques explore one of the most powerful — and often overlooked — drivers of aging: the immune system.Joined by immunologist Alan Landay, the conversation uncovers how chronic inflammation — often described as inflammaging — shapes biological aging at the cellular level. Drawing on decades of HIV research, Dr. Landay explains how persistent immune activation, gut barrier dysfunction, and microbiome imbalance contribute to age-related diseases long before symptoms appear.The episode dives into:• Why aging is a biological process — not just the passage of t...
2026-02-1824 min
Decoding LongevityBehind the Biotech Boom: Investing in the Age of Rejuvenation — A Conversation with Karl Pfleger, Ph.DIn this episode of Decoding Longevity, hosts Raghav Sehgal and Macsue Jacques are joined by Dr. Karl Pfleger — angel investor, longevity industry analyst, and creator of AgingBiotech.info.We explore the rapidly growing aging biotech ecosystem, including:Repairing aging vs. slowing agingRejuvenation biotech and combination therapiesLongevity investing, biomarkers, and regulationWhy ecosystems matter in aging researchA big-picture conversation on longevity science, rejuvenation, and the future of aging as a biological problem.
2026-02-0428 min
Drug DiariesRaghav Sehgal's AI Aging BREAKTHROUGH Will Change Everything!Discover the groundbreaking AI aging breakthrough by Raghav Sehgal! This technology will revolutionize longevity and health - a game-changer in the world of computational biology and venture capital. keywords artificial intelligence, aging, longevity, health technology, biomarkers, DNA methylation, venture capital, ethical considerations, personalized medicine, computational biology summary In this episode of Drug Diaries, host Kaushik Trivedi engages with Raghav Saigal, a computer scientist and researcher at the forefront of using AI and computational tools to revolutionize our understanding of aging. They discuss the potential of technology to unlock the secrets of longevity, the influence of key figures in the...
2026-01-241h 13
Decoding LongevityCities, Communities and Clinics: The New Testbeds for Longevity Research — A Conversation with Tina WoodsWhat if healthy longevity depends not only on your DNA, but on the city you live in, the air you breathe, and the communities you’re part of?In this episode, Raghav Sehgal and Macsue Jacques talk with Tina Woods — CEO of Collider Health and leading voice of the Human Exposome Project — about how environmental, social and lifestyle exposures shape aging.You’ll learn:What the human exposome is and why it drives most health outcomesHow cities, neighborhoods & clinics can become “living labs” for aging researchHow exposome data links w...
2025-12-0325 min
Decoding LongevityRejuvenating the Body with Stem Cells: A Conversation with Yuta from Accelerated BiosciencesWhat if we could produce safe, ethical, and infinitely renewable stem cells — without relying on embryos or complex reprogramming? In this episode, Raghav Sehgal and Macsue Jacques sit down with Yuta Lee, Founder and CEO of Accelerated Biosciences, to explore how his team is pioneering a new source of true pluripotent stem cells that could transform regenerative medicine and longevity research.We dive into:How Accelerated Biosciences discovered its unique stem cell lineWhy these cells could bypass major ethical and regulatory barriersThe potential to treat age-related diseases at their ce...
2025-11-0527 min
Decoding LongevityTargeting 7-Ketocholesterol in Atherosclerosis with Matthew “Oki” O’ConnorWhat if cardiovascular disease wasn’t just about high cholesterol — but about a toxic, oxidized form that drives plaque buildup and cellular dysfunction?In this episode, hosts Raghav Sehgal and Macsue Jacques talk with Matthew “Oki” O’Connor, a leading researcher exploring how 7-ketocholesterol fuels atherosclerosis — and how a new therapeutic candidate could reverse aspects of this age-related disease.We dive into: 💡 What makes 7-ketocholesterol so harmful 🔬 How targeting it can transform foam cells back into healthy macrophages 💊 How this approach differs from statins and tradition...
2025-10-2227 min
Decoding LongevityDecentralized Science and N-of-1 Trials with Jasmine Smith CEO of Rejuve.AIWhat if aging research didn’t just happen in labs but through a global community of people contributing their data and testing interventions in real time?In this episode, hosts Raghav Sehgal and Macsue Jacques talk with Jasmine Smith, CEO of Rejuve.AI, about how Decentralized Science (DeSci), AI, and n-of-1 trials are transforming personalized longevity research.👉 Learn more about Rejuve.AI: https://www.rejuve.ai/
2025-10-0822 min
Decoding LongevityEpigenetic Clocks and Anti-Aging Interventions with Brian KennedyWhat if we could measure and manage aging as precisely as we treat disease?In this episode of Decoding Longevity, host Macsue Jacques talks with Prof. Brian Kennedy from the National University of Singapore’s Healthy Longevity Translation Research Program about the future of precision medicine in aging.They explore:The LeanAge 2 Clock: a biomarker-based tool predicting biological age, mortality, and health risks.The Lipidomic (Dolly) Clock: uncovering lipid signatures linked to brain aging and Alzheimer’s.Why individuals respond differently to supplements, exercise, and drugs.The risk...
2025-09-2429 min
Decoding LongevityThe Roadmap to Precision Geromedicine with Prof. Andrea B . MaierWhat if healthcare could not just extend life, but extend healthy life?In Episode 13 of Decoding Longevity, hosts Raghav Sehgal and Macsue Jacques welcome Prof. Andrea B. Maier, a leading voice in geriatric medicine and longevity research, to explore the future of precision geromedicine.This episode uncovers how data-driven, personalized approaches are transforming the way we think about aging and health. Together, we dive into: Why precision medicine is key to understandingthe biology of aging How genetics, biomarkers, and lifestyle factorsguide interventionsThe importance of multi-organ and multi-systemdata in predicting health outcomes A vi...
2025-09-1036 min
Decoding LongevityEnsembleAge – Recalibrating the Biology of Time Dr. Amin HaghaniWhat if we could predict aging more accurately than ever before? In this episode of Decoding Longevity, we sit down with Dr. Amin Haghani (Altos Lab) to explore EnsembleAge, a powerful new epigenetic clock designed to integrate multiple biomarkers into a single measure of biological age.We discuss:Why EnsembleAge could represent the “next generation” of aging clocks 🧬The challenges of combining multiple models into one robust predictorHow epigenetic data is reshaping aging and longevity scienceThe clinical potential for personalized health, disease prevention, and lifespa...
2025-08-2721 min
The DNA of Things with Dr. Jeremy KoenigEpisode 73: The Symphony of Aging: Dr. Raghav Sehgal on Epigenetic Clocks & LongevityIn this episode, Dr. Jeremy Koenig sits down with Dr. Raghav Sehgal, a Yale-trained computational biologist and longevity researcher, to uncover the science behind aging, resilience, and the future of preventative medicine. From his unconventional journey starting in electronics engineering in India to pioneering breakthroughs in epigenetic clocks and system-specific biomarkers of aging, Dr. Sehgal reveals how technology, biology, and proactive healthcare intersect to redefine longevity. Together, they explore how aging is not a single timeline but a complex symphony across 11 bodily systems, why resilience is as important as lifespan, and how interventions—from intermittent fasting to pe...
2025-08-2756 min
Decoding LongevityNeddylation: The Hidden Switch of Neuronal Aging with Dr.Nathalie SauratWhat if aging in brain cells could be switched on—or reversed? In this episode of Decoding Longevity, hosts Raghav Sehgal and Macsue Jacques speak with Dr. Nathalie Saurat about her groundbreaking CRISPR screen revealing neddylation as a critical regulator of neuronal aging, Alzheimer’s disease progression, and protein turnover.You’ll learn how Nathalie:Generated 2.8 billion human stem-cell-derived neurons to uncover aging pathwaysDiscovered how inhibiting neddylation mimics age-related changes like tau aggregation, DNA damage, and loss of protein quality controlExplores ways to program age into neurons for better drug d...
2025-08-1317 min
Decoding LongevitySenolitics with Dr. Iman AzimiWhat if aging wasn’t a steady decline—but a mosaic of cellular behaviors?In this episode, we explore the complex biology of senescent cells with Dr. Iman Azimi, whose recent study using image-based single-cell profiling reveals an unprecedented diversity within these “zombie” cells.Together with hosts Dr. Raghav Sehgal and Dr. Macsue Jacques, we dive into:🧬 The hidden heterogeneity of senescent cells💊 Why one-size-fits-all senolytics might fail🔬 Rapamycin’s differential effects on cell subtypes🧠 The future of diagnostics for cellular agingDr. Azimi’s insights challenge many of the assumptions behind curre...
2025-07-3117 min
Decoding LongevityFrom Bench to Bedside: The Biomarkers of Aging Bottleneck with Dr. Chiara HerzogWe can now estimate your biological age from just a few drops of blood—but how close are we to using these tests in your doctor’s office?In this episode of Decoding Longevity, hosts Dr. Macsue Jaques and Dr. Raghav Sehgal sit down with Dr. Chiara Herzog, a molecular biologist and aging researcher at King’s College London, to unpack the translational bottlenecks holding back biomarkers of aging from clinical and public health applications.✨ Dr. Herzog is also our first-ever female guest, and she brings a refreshing, action-oriented lens to...
2025-07-1618 min
Decoding LongevityA Single Factor for Safer Cellular Rejuvenation — with Dr. Lucas Paulo de Lima CamilloCan one gene reverse aging without the cancer risk? In this episode, we sit down with Dr. Lucas Paulo de Lima Camillo to discuss SB000—a single factor that could make cellular rejuvenation safer and more effective.Lucas walks us through the science behind this new preprint, how SB000 compares to the well-known OSKM cocktail, and what this could mean for the future of aging therapies.🧬 Topics Covered:• Cellular reprogramming and safety• SB000 vs OSKM• Transcriptome-level biomarkers• Translational potential of single-gene therapies• The future of gene-driven longevity
2025-07-0325 min
Decoding LongevityPrecision Aging BiomarkersWhat if a single drop of blood could do more than tell your biological age? In this episode, we explore how cutting-edge epigenetic biomarker proxies and OMICmAge clocks can predict disease risk, personalize health interventions, and reshape how we approach aging itself.Our special guest, Dr. Varun Dwaraka, computational biologist and lead author of two groundbreaking papers, joins hosts Dr. Raghav Sehgal and Dr. Macsue Jacques to discuss:🔬 How methylation-based biomarkers outperform traditional lab tests🧬 What makes OMICmAge more powerful than previous aging clocks🏥 The clinical potential of remote, one-sample diagnostics🧠 Th...
2025-06-1818 min
Decoding LongevityThe Physics of Aging Part 2In this second part of our mind-expanding conversation with Peter Fedichev, co-founder of Gero, we explore what it will take to move longevity science forward.Peter argues that aging is a thermodynamic process — and that the loss of resilience begins before disease. So how can we detect that tipping point? And are mice really a dead end in anti-aging research?We also talk about:Why animal models fail usThe limits of cellular reprogrammingGero’s AI-driven approach to mapping aging as a systemWhat real anti-aging ther...
2025-06-0429 minDecoding LongevityThe Physics of AgingIs aging just the sum of diseases, or is it something deeper?In this episode, we’re joined by physicist and Gero founder Peter Fedichev, who introduces a groundbreaking new framework: aging as a loss of thermodynamic stability. We explore:Why aging is a systemic phenomenon beyond individual pathologiesHow concepts from physics and complex systems can redefine longevity scienceThe limits of cellular reprogrammingAnd why resilience—not disease-free survival—may be the key to a longer healthspan🎙 Hosted by Raghav Sehgal and Macsue JacquesStay wi...
2025-05-2127 minDecoding LongevityWhat does DNA methylation tell us about aging?What if your DNA holds the key to your true biological age? In this episode of Decoding Longevity, hosts Raghav and Macsue talk with Prof. Nir Eynon to explore how DNA methylation helps us measure, understand, and potentially reverse aging.🎙️ Based on: “Making Sense of the Ageing Methylome” – Nature Reviews Genetics (2022)📌 Learn about epigenetic clocks, exercise as an epigenetic intervention, and what methylation can tell us about your aging process.Follow for more episodes that decode the science of longevity!
2025-05-0720 minDecoding LongevityHow Biomarkers Could Help Us Slow AgingAging isn’t just about getting older — it’s about how we age.In this episode, we explore the emerging science of biomarkers of aging: what they are, why they matter, and how they could transform the way we approach health and longevity.We’re joined by Jessi Poganik, PhD (https://www.poganik.com/) — one of the authors of the paper “Biomarkers of Aging for the Identification and Evaluation of Longevity Interventions” PMC11088934, developed in collaboration with the Biomarkers of Aging Consortium.Together, we unpack:– The difference between biological and chronological age– What...
2025-04-2323 minDecoding LongevityHallmarks of AgingIn this episode, Dr. Raghav Sehgal and Dr. Macsue Jacques dive into the hallmarks of agingOriginally introduced in a groundbreaking 2013 paper by López-Otín, Blasco, Partridge, Serrano, and Kroemer, the Hallmarks of Aging outlined 9 key processes believed to drive the aging process.Fast forward to 2023, and the list has been expanded to 12, reflecting a decade of research and new insights into how and why we age.What does this mean for the future of regenerative medicine and aging interventions?
2025-04-0934 minDecoding LongevityThe Economic Value of Targeting AgingWhat if slowing aging could save trillions of dollars and improve millions of lives? This episode breaks down The Economic Value of Targeting Aging, a study that quantifies the economic benefits of longevity interventions. We dive into the science, the numbers, and the real-world implications of investing in aging research.
2025-03-2621 min
Siim Land Podcast#427 Longevity Scientist Shares What Affects Biological Age and How to Slow Aging - Raghav SehgalOrder my new book: https://www.amazon.com/dp/B0CW1B2XM1
Timestamps:
00:00 Intro
00:35 Raghav’s new study on epigenetic age
04:25 Biological age explained
10:45 How epigenetics affects aging
12:40 Biological age clocks and biomarkers
21:50 Top performers in lowering epigenetic age
32:20 How chronological age affects biological age
35:20 Gene therapies
40:10 Effect of diet and exercise
45:40 What biomarkers affect biological age
49:45 Organ aging
58:00 Final thoughts
Raghav Sehgal Twitter: https://twitter.com/rv_sehgal
Raghav Sehgal website: https://www.raghav-sehgal.com/
2024-11-151h 05
GenAI Automotive PodcastDriving Innovation with Raghav Sehgal - GenAI Maturity, Partnerships, and Automotive Use CasesIn this episode, I sat down with Raghav Sehgal, Co-Founder and Head of Sales at a21.ai, who previously served as a leader at AWS and SVP at Udacity, to explore the evolving role of Generative AI in the automotive industry. With his 16 years of global experience in AI, data, and digital transformation, Raghav shared invaluable insights on the varying approaches to GenAI maturity across industries, the strategic decisions between building in-house solutions versus partnering with tech providers, and the future of these partnerships. We also discussed the current and future roles of sensors and data, diving into real-world...
2024-08-1034 min
PEAK HUMAN LABS PodcastSecrets of Aging: Dr. Raghav Sehgal Reveals Breakthroughs in Epigenetic Clocks and Systems AgeJoin Dr. Sanjeev Goel in an interview with Dr. Raghav Sehgal, a PhD student at Yale and expert in epigenetic clocks. Discover how Dr. Sehgal's research sheds light on aging, from predicting chronological age to understanding the pace of aging and mortality risk. Learn about the concept of "systems age" and how different organs age at varying rates, impacting disease prevalence. Explore the potential for personalized treatments based on these findings. Dr. Sehgal also discusses the impact of lifestyle factors like diet and exercise on reversing epigenetic aging, offering practical insights for a healthier, more youthful life.
2024-04-0540 min
Everything EpigeneticsMOSAIC: Multi-Organ Scores of Aging across Integrated Components with Raghav SehgalVarious aging clocks have been developed to quantify the aging process and predict age-related diseases. These biological age clocks are powered by different types of omics data and clinical biomarkers, and they’re especially useful for observational studies, clinical trials, and basic science aimed at combating biological aging. Nonetheless, current research indicates that there is significant variation in aging, with deterioration and diseases affecting different organ systems and functional domains at different rates among individuals. While existing aging clocks can measure variations in the degree of aging, they do not account for variations in the way...
2023-08-3051 min