Shows
The Cracking Cancer PodcastNavigating the Complexity of Clinical Trials with Max Doppelt. Episode 42.In this high-stakes episode of "Cracking Cancer," Dr. Kyle Concannon and Samantha Murrell are joined by Max Doppelt, an engineer-turned-caregiver who transformed his mother’s terminal diagnosis into a mission for systemic change. Max shares the harrowing reality of navigating the "ivory tower" of oncology, where regulatory burdens and institutional silos often prevent patients from accessing the very drugs that could save them. From the heartbreak of failing trial screenings due to rigid exclusion criteria to the bold, life-saving decision to source a next-generation TKI from China during a trade war, this conversation pulls back the curtain on the lo...
2026-02-051h 03The Cracking Cancer PodcastWhat is Small Cell Transformation in Cancer? Episode 41.In this dedicated episode of "Cracking Cancer," host Dr. Kyle Concannon and co-host Samantha Murrell explore a challenging phenomenon in oncology: histologic transformation. This occurs when a cancer fundamentally changes its "wiring" to evade treatment, essentially transforming from one type of cell (like adenocarcinoma) into another, often more aggressive type (like small cell lung cancer).
The episode is dedicated to the memory of Caroline, a member of the lung cancer community who recently passed away after her EGFR-mutated cancer transformed into small-cell cancer. Dr. Concannon explains the biological "bucket" of resistance, distinguishing between new mutations in the...
2026-01-2958 minThe Cracking Cancer PodcastDo Respiratory Viruses Awaken Cancer with Dr. James DeGregori. Episode 40.In this high-impact episode of "Cracking Cancer," host Dr. Kyle Concannon is joined by patient advocate Samantha Murrell and Dr. James DeGregori, interim director of the University of Colorado Cancer Center. They discuss Dr. DeGregori’s groundbreaking study published in Nature, which explores how respiratory viruses—specifically SARS-CoV-2 and influenza—can act as a catalyst to "awaken" dormant cancer cells in the lungs.
Dr. DeGregori explains that while many cancer survivors may be ostensibly "cured," microscopic cancer cells can lie dormant for decades. His research reveals that acute inflammation caused by a new viral infection can trigger the rap...
2026-01-2257 minThe Cracking Cancer PodcastA Lab for Curative Intent Treatments with Dr. Concannon. Episode 38.In this revealing episode of "Cracking Cancer," host Dr. Kyle Concannon pulls back the curtain on his role as a physician-scientist at the University of Colorado. Joined by patient advocate Samantha Murrell, Dr. Kyle demystifies the "black box" of oncology research, discussing the intense process of setting up a new laboratory and the personal pivot that reshaped his career.
Dr. Kyle shares the logistical and emotional challenges of running an independent lab—from the high cost of reagents and the competitive nature of grant funding to the personal urgency that arose when his own boss was diagnosed wit...
2025-12-181h 07
Weird Kid VideoThe Long Kiss Goodnight (1996)This episode, "chef’s do that" - we are talking about The Long Kiss Goodnight (1996).
Written By Shane Black.
Directed By Renny Harlin.
Starring Geena Davis as Chaly Baltimore slash Samantha Caine and Samuel L Jackson as Mitch Hennessy.
Weird Kid Video is hosted by Keean Murrell-Snape, Kira Jade Oppitz and Brodie Kerrkillen.
Each sold separately.
New episodes every two weeks.
Don’t follow us on Instagram @weirdkidvideo
This podcast was recorded on Dharawal Country.
2025-12-172h 35The Cracking Cancer PodcastWhat Are Tyrosine Kinase Inhibitors (TKIs)? Episode 37.In this essential episode, host Dr. Kyle Concannon and co-host Samantha Murrell break down the science, promise, and limitations of Tyrosine Kinase Inhibitors (TKIs)—a class of highly effective, usually pill-form, targeted therapy.
Dr. Concannon explains that TKIs are molecular snipers, designed to attack the root cause of cancer by blocking the signaling from a mutated protein (kinase) that causes cells to divide uncontrollably. They clarify the process from DNA blueprint to protein addiction, explaining why these targeted therapies are often more elegant and have fewer side effects than traditional chemotherapy.
The discussion also tackles the...
2025-12-111h 01
Mums F**king Matter#109 Leading a Movement to Disrupt! (Amen!) — An Interview with Samantha MurrellSamantha Murrell is the Founder of Mothers' Hood. Samantha is leading a movement to disrupt the narratives around motherhood, work and ambition. Motherhood isn't the end of your career, it supercharges it.Samantha supports executive women into and through the transition into motherhood, whether that's for the first or fifth time!) and as they return to work, ready to smash their next big career goals. She is also a podcast host, speaker and author (in waiting!).*TRIGGER WARNING: From 52 minutes to 55 minutes Sam speaks about her struggles with postnatal anxiety.In this episode w...
2025-12-021h 09The Cracking Cancer PodcastMetastatic Consolidative Surgery with Dr. Allie Mungo & Patient Samantha Murrell. Episode 35 Part 02In the conclusion of this vital two-part series, host Dr. Kyle Concannon, Dr. Allie Mungo (Thoracic Surgeon), and post-operative patient advocate Samantha Murrell delve into the risks, recovery, and long-term rationale for surgical resections in Stage IV cancer patients.
Dr. Mungo details the different lung surgeries (wedge, segmentectomy, lobectomy, pneumonectomy) and the critical surgical complexities, including the "stickiness" caused by pre-surgical systemic therapies and the danger of operating close to major heart vessels. Samantha shares her candid, non-trivial recovery experience, highlighting the challenge of managing post-operative nerve pain and the emotional "slap in the face" of being...
2025-11-2739 minThe Cracking Cancer PodcastMetastatic Consolidative Surgery with Dr. Allie Mungo & Patient Samantha Murrell. Episode 34 Part 01In this riveting first part of a two-episode series, host Dr. Kyle Concannon, a medical oncologist, is joined in person by Dr. Allie Mungo, a thoracic surgeon, and patient advocate Samantha Murrell, who is just two weeks post-surgery for her Stage IV HER2-mutated lung cancer. They dive into the controversial topic of consolidative surgery—surgically removing residual tumor in patients with metastatic (Stage IV) cancer.
Samantha shares her personal journey, explaining how a remarkable response to targeted therapy—which rendered her PET scan active only at the primary tumor site—compelled her to "hunt down" a surgeo...
2025-11-2044 minThe Cracking Cancer PodcastWhat Is The Pharmaceutical Industry? Episode 32.In this revealing episode of "Cracking Cancer," host Dr. Kyle Concannon and co-host Samantha Murrell are joined by Kerry Wentworth, Chief Regulatory Officer at Nuvation Bio, to pull back the curtain on the pharmaceutical and biotech industry. Kerry, a veteran in the field, addresses the common perception that pharmaceutical companies are driven purely by financial metrics, stating that the primary mission is, in fact, patient-centered—to bring healthier, longer living to people.
The conversation dives deep into the high-risk reality of drug development. Kerry explains why drugs cost billions: the price must account for the staggering 90% failure ra...
2025-11-061h 05The Cracking Cancer PodcastWhat Are Antibody Drug Conjugates? Episode 30.In this crucial episode of "Cracking Cancer," host Dr. Kyle Concannon and patient advocate Samantha Murrell delve into Antibody Drug Conjugates (ADCs), a revolutionary class of targeted therapy. Samantha, who was treated with an ADC for her HER2 non-small cell lung cancer, shares her real-time experience with the drug's potent effects and cumulative side effects.
Dr. Concannon explains the sophisticated engineering behind ADCs: an antibody (the "key") is chemically linked to a highly toxic chemotherapy payload (the "bomb"). The goal is to specifically target cancer cells, providing the power of chemotherapy with fewer systemic side effects. The...
2025-10-231h 01The Cracking Cancer PodcastWhat Is A Medical Oncologist. Episode 29.In this essential episode of "Cracking Cancer," host Dr. Kyle Concannon, a physician scientist and medical oncologist, sits down with patient advocate Samantha Murrell to demystify the role of the medical oncologist and how they fit into a patient's care journey. They clarify the distinct but collaborative roles of medical, surgical, and radiation oncologists.
Dr. Concannon provides an honest, behind-the-scenes look at the high-stakes world of oncology, from the personal preparation required for a first patient meeting to the emotional toll of difficult end-of-treatment conversations. He discusses the inner workings of the Tumor Board, the realities of...
2025-10-161h 03The Cracking Cancer PodcastWhat Is Cancer Research? Episode 22.Welcome to a powerful new episode of "Cracking Cancer," where hosts Dr. Kyle Concannon and patient advocate Samantha Murrell pull back the curtain on the complex world of cancer research. In this candid discussion, they tackle the fundamental questions you've always wanted to ask:
Who are the key players in cancer research?
How is it funded, and why does it feel like progress is so slow?
From the "bench" in the lab to the "bedside" in the clinic, this episode explores the often-misunderstood journey of a potential cancer treatment. They demystify everything from government and pharmaceutical funding to the difference...
2025-08-281h 11The Cracking Cancer PodcastWhat Is Lung Cancer? Episode 21.In this episode, Dr. Kyle Concannon and patient advocate Samantha Murrell dive deep into lung cancer. They discuss the basics of lung cancer, how it forms, common misconceptions, and the differences between small cell and non-small cell lung cancers. They also cover the symptoms and signs of lung cancer, how it is diagnosed, the importance of molecular testing, and various treatment options, including chemotherapy, immunotherapy, targeted therapies, and more. This comprehensive discussion aims to bring clarity, hope, and practical information to anyone affected by lung cancer.
Chapters
(00:00) Introduction to Cracking Cancer
(01:42) How Lung Cancer Forms and Spreads
(04:40) Lung Nodules: What The...
2025-08-211h 09
Mothers' Hood10 - It’s Not the Glass Ceiling Holding Mothers Back with Tamsin Broster.In this episode, I’m joined by Tamsin Broster, feminist visibility and confidence coach, former Ministry of Defence leader, mother of two and all-round powerhouse. Tamsin shares her deeply personal story of stepping away from a 20-year civil service career to reclaim her identity, rebuild her confidence and rewrite what success means not just as a mother, but as a woman navigating loss, IVF, leadership, and the complexity of modern motherhood.This is a raw, rich, and honest conversation about what it means to live through matrescence in its fullest expression. From navigating IVF...
2025-07-2837 min
Mothers' Hood9 - Why Becoming A Mother Supercharges Your CareerListen up as I drop some truth bombs in this episode, waxing lyrical on why becoming a mother can accelerate your career like a bat out of h*ll!We’re telling mothers that they lack drive, determination, commitment and that when the baby arrives, that’s it, it’s game over for their career and they’ll just shuffle off into the background.But what if I told you this doesn't have to be the case?What if I told you that becoming a mother is a supercharged way of achievin...
2025-07-2128 min
Mothers' Hood8 - Letting go of the Perfect Family Ideal with Robin LynnIn this moving episode, I sit down with Robin Lynn. Robin is a clarity coach, speaker, musician and the unapologetic host of the Gucci God podcast. As the founder of Robin Lynn Coaching, Robin guides women through life’s pivots with power, prayer, and a little bit of cosmic spice.Robin shares her journey into and through motherhood. From navigating postpartum with bipolar disorder and infidelity to being blindsided in a custody battle, to redefining what it means to be a “good mother”. We talk about the expectations we carry, the stories...
2025-07-1427 min
Mothers' Hood7- From Supermum Addiction to Softening & Slowing Down with Layla O'MaraWe live in a culture that celebrates and almost idolises mothers who appear to do it all and have it all together. It’s a self-perpetuating cycle - we do more and more and are praised for doing so, so we continue to do more and more because that praise and recognition feels good. But this is often an appearance and frequently masks burnout and exhaustion. In episode 7, Layla O’Mara shares her experience of being Supermum and the effect it had on her.Listen as Layla shares The sta...
2025-07-0741 min
Mothers' Hood6 - The Friction of Modern Motherhood to A Feminist Awakening with Rachelle GlendonThe return to work for most mothers, who chose to or have to, is not smooth sailing. We have birthed and nurtured a new life and our lives have radically changed. Then we enter back into a world that does not recognise or value our mothering roles and the additional energy and time this requires. This week’s guest, Rachelle Glendon, experienced this ‘friction point’ after the birth of her second child. Listen as we discuss:The resentment and overwhelm Rachelle felt when she wasn’t able to fulfil her calling for ‘something mo...
2025-06-3051 minMothers' Hood5 - Who the h*ll am I?In this first solo episode, I open up about my own journey of becoming a mother and returning to work. The disorientation, the guilt, the tears and the transformation that followed. If you’ve ever asked yourself, “Who the h*ll am I now?” after becoming a mother, this one's for you.I share how discovering matrescence — the transformation of a woman to a mother — changed everything for me. From feeling lost, anxious and unseen, to finding clarity, purpose and confidence. And a lot of letting go of the things that no longer served me.
2025-06-1921 minMothers' HoodBONUS EPISODE! Masterclass - Wednesday 25th June 11am on Zoom. Mat to Back - Return to Work with Confidence + Clarity After Maternity LeaveIn this masterclass I’ll be talking about:⚪Identity and the huge shift that happens when we become a mother (and that isn’t universally understood) ⚪Why we don’t feel ambitious after we have kids⚪How this all affects confidence when returning to work after maternity leave⚪And I’ll show you what steps to take to feel confident and fired up when you return to work.This is for you if:✔ You are currently on maternity leave✔ You have achieved success...
2025-06-1102 min
Mothers' Hood3 - Finding Answers in Matrescence + Simple Steps with Gladys KangauBecoming a mother is a huge transition and one that is rarely celebrated, supported, and honoured in the ways that mothers need. This leaves mothers disoriented, lost, and exhausted.Gladys Kangau experienced all of this after the birth of her first child. She was told she had post-partum depression but believed it was something else. This started her on a journey of searching for her truth and led her to find matrescence which helped her to make sense of her mothering journey. We discuss:The cultural expectations of a ‘good mother’ in KenyaHow finding matres...
2025-06-0151 min
Mothers' Hood4 - High Risk Pregnancy + Losing a Village to Reclaiming Power with Kylie Blascetta*Content/trigger warning – references to suicidal ideation and potential miscarriage*Pregnancy is often a complex time of joy and celebration mixed in with worry, anxiety, uncertainty, physical pain, nausea, sickness, exhaustion, and everything in between. But for some women, there is little enjoyment because of the risk that their baby might not survive the pregnancy or for long after the birth.This was the reality for our guest, Kylie Blascetta.Kylie shares:Discovering early on that her baby might not survive the pregnancy due to a la...
2025-06-011h 19
Mothers' Hood2 - Being Your Own Hero - Thriving After Domestic Abuse with Lucy Wylde*Trigger Warning *Domestic Violence*Entering motherhood and looking after a newborn baby can be challenging enough without adding what Lucy Wylde had to deal with. In this episode, Lucy bravely shares her experience with domestic violence in the form of coercive control. She discusses this abuse by her partner which appeared shortly after her daughter was born and the journey to leaving her partner several years later. Lucy is a beautifully empathic soul and you will hear how deeply she feels and expresses her emotions.You will learn: · How the abuse manifested and the sign...
2025-06-0150 min
Mothers' Hood1 - From Rage & Anger to a Calm & Centred Motherhood with Alison RyanThe very first episode of the Mothers’ Hood Podcast explores the taboo topic of rage and anger in motherhood with Alison Ryan. Alison shares her experience of the overwhelming rage she felt after having her second daughter. This is a topic that is rarely discussed or acknowledged and is shrouded in so much shame and guilt. We discuss:How the rage and anger manifested and the self-judgment she had in feeling this wayAlison’s breaking point, resulting in smashing plates in the sink, and how this was a key moment for her to rec...
2025-06-0139 min
Mothers' HoodTrailer EpisodeTune in to raw and honest conversations about motherhood, identity, and the messy beauty of it all.These are the stories we should have heard growing up, as we navigated pregnancy and motherhood - the real, unfiltered truths of the journey.Yet, we live in a world where mothers often find themselves isolated, navigating the ups and downs of parenting alone.Without hearing others' stories, we lack the reference to make sense of our own experiences and the language to express what we're feeling. This leaves many mothers feeling disconnected, lost and questioning...
2025-05-2805 minWeird Kid VideoThe Exterminator (1980)This episode, New York is a war zone and only one man just like all the other one men has the guts to fight back - we are talking about The Exterminator (1980).
Written & Directed By James Glickenhaus.
Starring Robert Ginty as John "The Exterminator" Eastland, Christopher George as Detective James Dalton, Samantha Egger as Dr. Megan Stewart and Steve James as Michael Jefferson.
Weird Kid Video is hosted by Keean Murrell-Snape, Kira Jade Oppitz and Brodie McDonald. Each sold separately.
New episodes every two weeks.
Don’...
2025-05-212h 16The Cracking Cancer PodcastCommunity Vs. Academic Oncology. Episode 06In this episode, Dr. Kyle Concannon and co-host Samantha Murrell are joined by oncologist Dr. Ben Fangman to discuss the differences between community and academic oncology, or in simpler terms, research hospitals vs. the traditional hospitals most people are accustomed to. Discover the unique challenges and benefits of each, and learn how to navigate your cancer care journey effectively. Whether you're a patient seeking clarity or a supporter wanting to understand more, this conversation is packed with valuable insights.
The Cracking Cancer Podcast's main focus is to further education about cancer and its effects on p...
2025-05-081h 02The Cracking Cancer PodcastThe 1st Oncology Visit. Episode 04Your First Oncology Visit: What to Expect and How to Prepare
In this episode of Cracking Cancer, Dr. Concannon and Samantha Murrell, a patient advocate with stage four non-small cell lung cancer, discuss the essential aspects of the first oncology visit.
They tackle critical topics such as the emotional and logistical preparation, the importance of bringing medical records and support systems, understanding the diagnosis, and managing the waiting period before treatment begins.
Samantha shares her personal experiences and anxieties, while Dr. Concannon provides valuable insights into what patients can expect during this crucial first step in cancer care. Tune in to...
2025-04-2454 minThe Cracking Cancer PodcastWhat is Cancer Metastasis? Episode 03In this episode, Dr. Kyle Concannon, and Co-Host Samantha Murrell are taking a deeper dive into the complexities of metastasis, discussing what metastatic disease means, its implications for treatment, and how it varies across different types of cancer.
Samantha shares her personal journey, shedding light on common misconceptions and the emotional toll of living with stage four cancer. Tune in to understand the biological processes behind metastasis, the importance of staging, and why stability in cancer treatment is worth celebrating!
The Cracking Cancer Podcast's main focus is to further education about cancer and i...
2025-04-101h 00The Cracking Cancer PodcastWhat Is Chemotherapy? Episode 02Dr. Kyle Concannon and Co-Host Samantha Murrell talk all things chemotherapy in this episode of Cracking Cancer. They tackle common myths and misconceptions in the public sphere regarding chemo, and dive into Samantha's first-hand experiences battling Stage 4 Lung Cancer and receiving continuous chemotherapy infusions.
The Cracking Cancer Podcast's main focus is to further education about cancer and its effects on people and communities through continued discussion and to raise funds for the continued research of cancer treatments and positive outcomes. All raised proceeds go directly to the continued upkeep of this podcast and cancer research. T...
2025-04-0359 minThe Cracking Cancer PodcastWhat is Cancer? Episode 01Understanding Cancer: From Diagnosis to Treatment and Support
In this very first episode of the Cracking Cancer podcast, Dr. Kyle Concannon, MD and patient advocate Samantha Murrell, focus on answering the fundamental question: 'What is cancer?'
Dr. Concannon explains the basic biological ways that cancer works, including mutations and cell regulation, while Samantha shares her personal journey with stage four non-small cell lung cancer. The discussion covers the complexity and variability of cancer, the impact of lifestyle factors, the significance of molecular profiling, and the importance of early diagnosis and staging.
2025-02-1457 min
The Steel CageThe Steel Cage 7-23-23 WWE Screws L.A.Knight Again!This week WWE gave us good news [Dirty Dom winning his first singles title] and bad [L.A. Knight gets screwed out of his]. I have a lot to say regarding both subjects. Buddy Lee looks at how this year's Summer Slam card is shaping up. Since I enjoy Samantha Irvin's ring announcing (especially for Imperium) I thought I'd look back at some of the best ring announcers over the years. D.S.O.T.R. featured Abdullah "The Butcher" who for a big man looks good for 82 years old. Buddy Lee debates the controversial claims Abby can't read or...
2023-07-242h 00Weird Kid VideoPump Up The Volume (1990)This week the weird kids are glued to the VCR with huey gluey - we are talking (hard) about Pump Up The Volume from 1990.
Written & Directed By Allan Moyle.
Starring Christian Slater as Mark Hunter (aka) Happy Harry Hard-on & Samantha Mathis as Nora De Niro.
Watch the trailer here.
Find the movie in your region via Just Watch.
Weird Kid Video is hosted by Keean Murrell-Snape, Kira Jade Oppitz and Brodie McDonald. Each sold separately.
Don’t follow us on Instagram and the B...
2022-11-282h 26