Shows
Freely Filtered, a NephJC PodcastFF 81 Metformin Termination as explored by Target Trial EmulationThe FiltrateJoel Topf Bluesky: @kidneyboy.bsky.socialJordy Cohen Bluesky: @jordybc.bsky.socialSwapnil Hiremath Bluesky: @hswapnil.medsky.socialSpecial Guest Edouard “call me Ed” Fu Assistant Professor and Medical Student, and second author of his second paper covered on NephJC. LinkedIn | Leiden University Medical CenterEditing bySimon Topf and Sophia AmbrusoThe Kidney Connection written and performed by by Tim YauShow NotesEd’s first paper on NephJC: Timing of dialysis initiation to reduce mortality and cardiova...2025-07-121h 19
Freely Filtered, a NephJC PodcastFF 80 KDIGO ADPKD Guideline DraftThe FiltrateJoel TopfAC GomezSophia AmbrusoNayan AroraSpecial Guest Charles Edelstein, MD, PhD Professor, Medicine-Renal Med Diseases/HypertensionExtra-Special GuestMichelle Rheault, MD Professor of Pediatrics, University of MinnesotaEditing bySimon and Joel TopfThe Kidney Connection written and performed by by Tim YauShow NotesKDIGO ADPKD Guidelines:WebsiteGuideline PDFExecutive Summary PDFNephJC coverage...2025-05-131h 18
Freely Filtered, a NephJC PodcastFF 77 Top Nephrology Stories 2024The FiltrateJoel TopfSwapnil HiremathAC GomezSopia AmbrusoNayan AroraSpecial Guests Michelle Rheault, Director, Division of Pediatric Nephrology, Professor of MedicineTiffany Caza, Nephropathologist, Scientist and self-described Freely Filtered fan girlEditing bySimon Topf and Sophia AmbrusoShow Notes10. Healthcare Cyberattacks9. ApoE in C3 glomerulonephropathy8. Workforce woes in Adult and Pediatric Nephrology7. Hyponatremia correction meta-analysis6. Microvascular inflammation increases risk of graft loss...2025-02-261h 12
Freely Filtered, a NephJC PodcastFF 74: Amino Acids for AKIThe Filtrate:Jennie LinJoel TopfJosh WaitzmanSwapnil HiremathWith Special GuestsPedro TeixeiraJay KoynerEditor Sophia AmbrusoShow NotesThe article: A Randomized Trial of Intravenous Amino Acids for Kidney ProtectionNephJC SummaryKDIGO Clinical Practice Guideline for Acute Kidney Injury (PDF)Steve Coca study Evaluation of Short-Term Changes in Serum Creatinine Level as a Meaningful End Point in Randomized Clinical Trials (PubMed)Using Nephrocheck to...2024-10-191h 32
Freely Filtered, a NephJC PodcastFF 73: The KDIGO 2024 CKD Guideline DraftThe draft order:Sophia AmbrusoNayan AroraSwapnil HiremathAC GomezJoel TopfEditor Nayan AroraShow NotesPrevious drafts:2021 KDIGO Hypertension —Joel, Sophia, Swap, Nayan, Josh2021 ASN Kidney Week Draft—Joel, Sophia, Swap, Nayan, Jennie2022 The ISPD Peritonitis Guideline— Joel, Sophia, Swap, Nayan2022 ASN Kidney Week Draft—Joel, Sophia, Swap, Nayan2023 ASN Kidney Week Draft—Joel, Sophia, Swap, Nayan, AC, Josh2024 KDIGO CKD Clinical Practice Guideline —Joel, Sophia, Swap, Nayan...2024-08-011h 32
Freely Filtered, a NephJC PodcastFF 72: Nefecon for IgAN, The NefIgArd part B trialThe Filtrate:Joel TopfJosh WaitzmanWith Special Guest:Brad Rovin (@BradRovin) Chief of nephrology at The Ohio State University Wexner Medical Center, one of the authors of the Nefigard trial. Koyal Jain (@koyaljainMD) Program director of the GN Fellowship at University of North CarolinaRoger Rodby (@NephRodby) Associate program director of the Rush University Nephrology FellowshipEditor Sophia AmbrusoShow NotesThe manuscript (The Lancet | PubMed | NephJC)The Results of Part A (Kidney Int | PubMed)2024-06-151h 32
Freely Filtered, a NephJC PodcastFF 71: Semaglutide for diabetic nephropathy FLOWThe Filtrate:Joel TopfSwapnil HiremathJosh WaitzmanNayan AroraSophia AmbrusoWith Special Guest:Brendon Neuen Super smart guy and clinical trialistVlado Perkovic Lead author of FLOW and friend of NephJCEditor Joel TopfShow NotesThe manuscript (NEJM): Effects of Semaglutide on Chronic Kidney Disease in Patients with Type 2 DiabetesThe acronym FLOW from the title: evaluate renal Function with semagLutide Once Weekly (Twitter)Joel wrote a blog...2024-06-011h 23
Kidney EssentialsLet's Get to the Heart of Potassium!In this episode, Drs. Young and Ambruso discuss not just treating hypokalemia but the importance if determining the cause with a specific emphasis on GI losses and the role the kidney plays.Sophia Ambruso DO @Sophia_Kidney, Sarah Young MD @kidneycritic, Judy Blaine MD, Parisa Mortaji, MD2024-04-1925 min
Freely Filtered, a NephJC PodcastFF67: NephMadness Animal HouseAnimal House RegionNephMadness description by Tiffany TruongEditorial by Kelly Hyndman @DrKeeksPhD They May Look Cute, But Are All Animals Sweet?The Filtrate:Joel TopfSwapnil HiremathSophia AmbrusoJosh WaitzmanWith Special Guest:Kelly HyndmanEditor:Sophia AmbrusoShow NotesAnimal House 2018 with Mark Zeidel, MD (AJKDblog)Animal House 2021 with Kelly Hyndman (AJKDBlog)Animal House 2022 with Kelly Hyndman (AJKDBlog)Mount Desert Island Summer...2024-03-0747 min
Freely Filtered, a NephJC PodcastFreely Filtered 065: BEST FluidsThe Filtrate:Joel TopfNayan AuroraSophia AmbrusoWith Special Guest:Michael CollinsEditor:Nayan AuroraShow Notes:Twitter is now X (NYT)Michael Collins (the astronaut, not the real one)PlasmaLyte by BaxterNephJC BEST Fluids summaryEarly Goal Directed Therapy for Sepsis NEJM manuscript which changed practice patterns and welcomed in an era of massive fluid resuscitation.PLUS Trial NEJMSPLIT Trial JAMA...2024-02-101h 10
Freely Filtered, a NephJC PodcastFF 64 Kidney Week LiveThe Filtrate:Joel TopfSwapnil HiremathSophia AmbrusoAC GomezJosh WaitzmanJennie LinNayan AroraThe CurbsidersMatt F. Watto (@DoctorWatto)Paul Nelson Williams, America’s primary care physician (@PaulNWilliamz)With Special Guest:JD Foster (@KidneyVet)Sayed Tabatabai (@TheRealDoctorT) Nephrologist in Austin and the author of These Vital SignsMichelle Rheault (@rheault_m) Chief of Pediatric Nephrology at the University of Minnesota and lead author of th...2023-11-121h 32
Freely Filtered, a NephJC PodcastFreely Filtered 63: Late Breaking and High Impact Clinical TrialsThe Filtrate:Joel TopfSwapnil HiremathSophia AmbrusoAC GomezWith Special Guest:Amit Garg (@AmitXGarg) Nephrologist at Western University, London, and lead PI of the EnAKT LKD trial. Susan Q. McKenzie (LinkedIn) Co-Founder & Chair, Transplant Ambassador Program. President of the Kidney Patient and Donor Alliance of Canada.Editor:Joel TopfShow Notes:Late Braking and High Impact Clinical Trial press releaseJAMA Internal MedicineMyTEMP trial Personalised cooler dialysate for patients receiving m...2023-11-032h 05
Freely Filtered, a NephJC PodcastFreely Filtered 62: Inaxaplin for APOL1 Kidney DiseaseThe Filtrate:Joel TopfJennie LinJosh WaitzmanWith Special Guest:AC Gomez MedPeds nephrology fellow at Mass General/Brigham and Boston Children’s | TwitterGentian Hall Assistant Professor of Medicine Duke Department of MedicineEditor:Sophia AmbrusoShow Notes:APOL1 review by the OG Scientists APOL1 Nephropathy: From Genetics to Clinical ApplicationsMYH9 and APOL1 connection: The population genetics of chronic kidney disease: insights from the MYH9–APOL1 locusMartin Pollack LabVert...2023-09-251h 31
Freely Filtered, a NephJC PodcastFreely Filtered 09: Torsemide v FurosemideThe Filtrate:Joel TopfNayan AroraSophia AmbrusoWith Special Guest:Boback Ziaeian @boback Assistant Professor of Medicine David Geffen School of Medicine at UCLA. His Google Schoolar page is better than yours. And returning for her fourth time (why do we keep inviting her back?)Sadiya Khan @heartDocSadiya Assistant Professor of Medicine (Cardiology) and Preventative Medicine at Northwestern Feinberg School of Medicine. LinkEditor:Priya YenebereShow Notes:Diuretic Therapy review by. Craig...2023-07-031h 02
Freely Filtered, a NephJC PodcastFreely Filtered 060: HCTZ v Stones. The NOSTONE TrialThe Filtrate:Joel TopfSwapnil HiremathJosh WaitzmanNayan AroraSophia AmbrusoWith Special Guest:Megan Prochaska Assistant professor of medicine at University of Chicago John Asplin Medical Director Consultant LithoLink (Twitter)Editor:Joel TopfShow Notes:The LithoLink websiteStone Camp tweetPrevention of Repeated Episodes of Kidney Stones in Adults: A Clinical Practice Guideline From the American College of Physicians (link)...2023-06-251h 42Kidney EssentialsPeak your Ts, flatten your Ps, widen your QRS: The ABCs of hyperkalemiaIn this episode, Drs. Mortaji, Ambruso and Young discuss the nuances of hyperkalemia diagnosis and management.Sophia Ambruso DO @Sophia_Kidney, Sarah Young MD @kidneycritic, Judy Blaine MD, Parisa Mortaji, MD2023-05-1741 minKidney EssentialsUrine for a treat: Urinary sediment 201 - Clinical CasesIn this episode Drs. Young, Mortaji and Ambruso again invite Dr. Juan Carlos Velez, acclaimed nephrologist and self-proclaimed "piss-prophet" Dr. Juan Carlo Velez to discuss specific cases and how urinalysis and urinary sediment help the diagnosis. Dr. Juan Carlo Velez is the Department Chair at Oschner Medical Center in New Orleans, LA. You can find Dr. Velez's other podcast at "Channel Your Enthusiasm - The Burton Rose Book Club". Check out Dr. Velez at his Twitter handle @VelezNephHepatoEdited by: Parisa Mortaji, MD and Sophia Ambruso, DOSophia Ambruso DO @Sophia_Kidney, Sarah Young MD @ki...2023-04-1726 minKidney EssentialsUrine for a treat: Urinary sediment 101In this episode, Drs. Young, Ambruso & Mortaji discuss the ABCs of urinalysis and urinary sediment, They are joined by the acclaimed nephrologist and self-proclaimed "piss-prophet" Dr. Juan Carlo Velez, Department Chair at Oschner Medical Center in New Olreans, LA. You can find Dr. Velez's other podcast at "Channel Your Enthusiasm - The Burton Rose Book Club". Also, check out Dr. Velez at his Twitter handle @VelezNephHepatoEdited by: Parisa Mortaji, MD & Sophia Ambruso, DOSophia Ambruso DO @Sophia_Kidney, Sarah Young MD @kidneycritic, Judy Blaine MD, Parisa Mortaji, MD2023-04-1738 min
Freely Filtered, a NephJC PodcastFreely Filtered 057: NephMadness TMAThe Filtrate:Joel TopfSwapnil HiremathJosh WaitzmanSophia AmbrusoWith Special Guest:Anna Vinakova Associate Professor of Medicine at Virginia Commonwealth University. NephMadness Executive. Vanuja Java is a transplant nephrologist at Washington University in St. Louis, MO. Her research involves functional characterization of genetic variants in complement-mediated diseases. She co-chairs the ClinGen complement gene curation expert panel.Editor:Sophia AmbrusoShow Notes:#NephMadness 2023: Thrombotic Microangiopathy RegionTMA Review article in the NEJM from 2014: Syndromes...2023-03-111h 21
Freely Filtered, a NephJC PodcastFreely Filtered 056: MYTEMPThe Filtrate:Joel TopfSwapnil HiremathNayan AroraSophia AmbrusoWith Special Guest:Amit Garg @AmitXGarg, Nephrologist at Western University, London, and lead PI of the MYTEMP trial. Editor:Joel TopfShow Notes:MyTEMP in pubmed: Personalised cooler dialysate for patients receiving maintenance haemodialysis (MyTEMP): a pragmatic, cluster-randomised trialMyTEMP Summary on NephJC It’s really cold in OntarioThe NephTrials blog summary on Pragmatic TrialsThe pragmatic TiME trial on long...2023-02-071h 21
Freely Filtered, a NephJC PodcastFreely Filtered 054: EMPA-KidneyThe Filtrate:Joel TopfSwapnil HiremathJosh WaitzmanSophia AmbrusoPriya Yenebere With Special Guest:Brendon Neuen, Secretariat of the SGLT2 Trialists Consortium and cool guy on Twitter. Editor: Sophia AmbrusoShow Notes:Joel’s Conflict of Interest Statement. Sophia is also conflicted with Astra Zeneca and Brendon with everybody in the SGLT2i space.Joel starts off with a history of SGLT2iEMPA-REG Outcomes. First!CANVAS. OMG th...2022-12-251h 31
Freely Filtered, a NephJC PodcastFreely Filtered 053: Kidney Week DraftThe Filtrate:Joel TopfSwapnil HiremathNayan AroraSophia AmbrusoEditor: Nayan AroraShow Notes:Joel’s Conflict of Interest StatementThe Draft Board EMPA-Kidney is “off the board”Lunch Symposium on Current and Future Approaches to the Diagnostic Assessment and Management of AKI in Patients with Cirrhosis provided by an educational grant from Mallinckrodt PharmaceuticalsThe CONFIRM Trial Terlipressin plus Albumin for the Treatment of Type 1 Hepatorenal Syndrome in NephJCClinic...2022-12-111h 04
Freely Filtered, a NephJC PodcastFreely Filtered 052: ADVORThe Filtrate:Joel TopfJordy CohenNayan AroraSophia AmbrusoSpecial Guests:Boback Ziaeian @boback Assistant Professor of Medicine David Geffen School of Medicine at UCLA returns for his second episode (SODIUM-HF). His Google Schoolar page is better than yours. David Ellison @dhekidney is professor of medicine at Oregon Health Science University and head of the Oregon Clinical & Translational Institute. Show Notes:Ultrafiltration in Decompensated Heart Failure with Cardiorenal Syndrome (The CARESS Trial)Ultrafiltration versus intravenous diuretics for patients...2022-11-261h 09Kidney EssentialsCan you still drink milk if you have calcium oxalate stones?In this episode, Drs. Sophia Ambruso and Sarah Young welcome a new addition to the Kidney Essentials team, Dr. Parisa Mortaji! We also discuss why we care about nephrolithiasis (kidney stones) with a specific emphasis on calcium oxalate stones, why people form stones (hint: it's in the urine!!) as well as dietary counseling and additional medical interventions that improves stone absorption and prevents further stone formation!Sophia Ambruso DO @Sophia_Kidney, Sarah Young MD @kidneycritic, Judy Blaine MD, Parisa Mortaji, MD2022-09-2733 min
Freely Filtered, a NephJC PodcastFreely Filtered 049: Sodium-HFThe Filtrate:Joel TopfSwapnil HiremathJosh WaitzmanSophia AmbrusoSpecial Guests:Boback Ziaeian @boback Assistant Professor of Medicine David Geffen School of Medicine at UCLA. His Google Schoolar page is better than yours. And returning for her third time (why sdo we keep inviting her back?)Sadiya Khan @heartDocSadiya Assistant Professor of Medicine (Cardiology) and Preventative Medicine at Northwestern Feinberg School of Medicine. LinkEditor: Sophia AmbrusoDonate to NephJCGet your Freely Filtered Mug by becoming...2022-09-131h 11
Freely Filtered, a NephJC PodcastCHAP, changing how we treat hypertensionin pregnancyThe Filtrate:Joel TopfNayan AroraSophia AmbrusoSwapnil HiremathJosh WaitzmanSpecial Guest:Natalie Bello Director of Hypertension Research at Cedars SinaiEditor:Nayan AroraShow Notes:NephJC summary of CHAPCHiPS TV showCHIPS study: Less-Tight versus Tight Control of Hypertension in PregnancyPrevention, Diagnosis, and Management of Hypertensive Disorders of Pregnancy: a Comparison of International Guidelines (Pubmed)SFLT in preeclampsia from where...2022-06-301h 19
Freely Filtered, a NephJC PodcastISPD 2022 Peritonitis Guideline DraftThe Filtrate:Joel TopfNayan AroraSophia AmbrusoSwapnil HiremathSpecial Guest:Jade TeakallJeff Perl, Great Twitter handle, PD_PerlsEditor:Joel TopfShow Notes:ISPD 2022 Peritonitis GuidelinesNephJC DiscussionDimitrios Oreopoulos obituary in JASN. Peritoneal Dialysis International: Journal of the International Society for Peritoneal DialysisThe draft board: Google DocThe PROMPT Study showing delayed peritonitis treatment increases the...2022-05-141h 22
Freely Filtered, a NephJC PodcastSalt Substitution and Stroke StudyThe Filtrate:Joel TopfJoshua WaitzmanNayan AroraJennie LinSophia AmbrusoSpecial Guest:Paul A Welling Editor:Sophia AmbrusoShow Notes:NephJC Summary on SSaSSPaul Welling’s tweetorial on the potassium switchThe 2016 Canadian Hypertension guidelines were the first to suggest adding potassium: Hypertension Canada's 2016 Canadian Hypertension Education Program Guidelines for Blood Pressure Measurement, Diagnosis, Assessment of Risk, Prevention, and Treatment of HypertensionSwapnil’s Potassium Trial: Diet...2022-05-091h 09
Freely Filtered, a NephJC PodcastNephMadness Animal HouseThe Filtrate:Joel TopfJoshua WaitzmanNayan AroraSophia AmbrusoJordy CohenSpecial Guest:Kelly HyndmanEditor:Joel TopfPodCrawlMonday, March 14: The Curbsiders An Internal Medicine Podcast…for the Internist. This episode will focus on the Cardiorenal region with Game Maker, Joel Topf @Kidney_Boy, and Selection Committee Member, Sadiya Khan @HeartDocSadiya. Listen on Apple or SpotifyTuesday, March 15: The Drs. WashingtonThe Drs. Washing...2022-03-191h 00Kidney EssentialsWhat did you read in 2021 that changed your practice?Drs. Young, Ambruso & guest speaker, current University of Colorado nephrology fellow extraordinaire & future faculty Dr. Ruth Campbell, discuss some of their favorite 2021 practice changing literature. Join us!Sophia Ambruso DO @Sophia_Kidney, Sarah Young MD @kidneycritic, Judy Blaine MD, Parisa Mortaji, MD2022-03-1737 min
Freely Filtered, a NephJC PodcastAnti-Nephrin Antibodies Cause Minimal Change Disease. Wait...What?The Filtrate:Joel TopfJennie LinJoshua WaitzmanNayan AroraSophia AmbrusoSpecial Guest:Astrid Weins (@AstridWeins) renal pathologist at the Brigham and Woman’s Hospital and Harvard Medical SchoolEditor:Nayan AuroraShow Notes:Summary of minimal change disease according to the orthodoxy: Light microscopy of renal biopsy specimens from patients with MCD shows minimal to no change; however, electron microscopy reveals the effacement of podocyte foot processes. To add to the conundrum, immunofluorescent staining of biopsy...2022-02-271h 17Kidney EssentialsTo NSAID or not to NSAID - Manny vs Sophie - NSAIDS part 2In this episode, Manny and Sophie discuss NSAID use in the healthy population. What does the data support? Is Sophie's regular use of NSAIDs going to land her on dialysis? Or will Manny's NSAID aversion result in a healthy set of kidneys in exchange for some unnecessary aches and pains?Sophia Ambruso DO @Sophia_Kidney, Sarah Young MD @kidneycritic, Judy Blaine MD, Parisa Mortaji, MD2022-01-3019 minKidney EssentialsHow much ibuprofen is too much ibuprofen?? Part 1Drs. Ambruso, Young and Urra discuss the mechanism of action of NSAID use, how they affect GFR and the populations at risk of developing AKI with NSAID use.Sophia Ambruso DO @Sophia_Kidney, Sarah Young MD @kidneycritic, Judy Blaine MD, Parisa Mortaji, MD2021-11-2316 minKidney EssentialsWhat are the nuts and bolts of diabetic nephropathy diagnosis and treatment?In this episode, Kidney Essentials hosts Drs. Sophia Ambruso and Judy Blaine along with guest-host Dr. Jake Hershey discuss the diagnosis and treatment of diabetic nephropathy and some of the nuances of our favorite RAAS inhibition medications.Sophia Ambruso DO @Sophia_Kidney, Sarah Young MD @kidneycritic, Judy Blaine MD, Parisa Mortaji, MD2021-09-1025 minKidney EssentialsWhat is RAAS? Why does inhibition of RAAS help in diabetic kidney disease?In this episode Drs Ambruso and Young review the role of renin, angiotensin, and aldosterone in the pathogenesis of diabetic kidney disease and its treatmentSophia Ambruso DO @Sophia_Kidney, Sarah Young MD @kidneycritic, Judy Blaine MD, Parisa Mortaji, MD2021-07-1533 minKidney EssentialsHow do I know diabetes is affecting the kidneys?In this episode, Drs. Young, Blaine and Ambruso discuss the diagnosis of diabetic nephropathy and how having diabetic kidney disease impacts an individuals cardiovascular and mortality outcomes.Sophia Ambruso DO @Sophia_Kidney, Sarah Young MD @kidneycritic, Judy Blaine MD, Parisa Mortaji, MD2021-05-2022 minKidney EssentialsWhat did you read in 2020 that changed your practice?Drs. Ambrusio, Blaine and Young discuss articles that most influenced their care of patients with kidney disease in the last year.Sophia Ambruso DO @Sophia_Kidney, Sarah Young MD @kidneycritic, Judy Blaine MD, Parisa Mortaji, MD2021-03-1135 minKidney EssentialsWho cares if its protein or albumin in the urine?Drs. Young, Blaine and Ambruso discuss albuminuria and proteinuria, specifically how to measure and interpret values, and what that means for our patients.Sophia Ambruso DO @Sophia_Kidney, Sarah Young MD @kidneycritic, Judy Blaine MD, Parisa Mortaji, MD2021-02-0227 minKidney EssentialsCan giving normal saline ever be a bad thing?Drs. Young, Blaine and Ambruso explore a case of SIADH, why we DON'T use normal saline in SIADH and how to correct symptomatic hyponatremia.Sophia Ambruso DO @Sophia_Kidney, Sarah Young MD @kidneycritic, Judy Blaine MD, Parisa Mortaji, MD2020-11-2727 min