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Base by BaseBase by BaseđŸŽ™ïž 74: Benchmarking T Cell Receptor–Epitope Predictors with ePytope-TCRđŸŽ™ïž Episode 74: Benchmarking T Cell Receptor–Epitope Predictors with ePytope-TCR🧬 In this episode of PaperCast Base by Base, we explore a unified computational framework that integrates and benchmarks 21 T cell receptor–epitope binding prediction models to evaluate their performance on viral epitope repertoires and deep mutational scans.🔍 Study Highlights:The authors developed ePytope-TCR, which standardizes 18 general and three categorical prediction methods into a single interoperable platform compatible with common TCR repertoire formats. They assessed model performance on 638 epitope-specific TCRs from single-cell datasets and found that only a few predictors achieved moderate accuracy, exhibiting strong biases toward frequently studied epitope...2025-07-1320 minOn AIRR - Immune receptors in the clinicOn AIRR - Immune receptors in the clinicOn AIRR 18: From single-chain TCR sequencing to paired high-throughput methods with Paul ThomasIn this episode of On AIRR, Dr. Paul Thomas, reviews advances in the field of TCR sequencing. Dr. Thomas is a faculty member in the Department of Immunology of St. Jude Children’s Research Hospital. His work has advanced our understanding of innate and adaptive immune responses and TCR specificity with a focus on responses to viral infections. In Episode 18 of On AIRR, Dr. Thomas shares his journey from immunoparasitology to pioneering TCR repertoire sequencing. He began his scientific career studying innate immune responses to parasites during his graduate work in immunoparasitology. Motivated by a desire to us...2025-06-0946 minBeyond Biotech - the podcast from LabiotechBeyond Biotech - the podcast from LabiotechTCR-NK: A novel cell therapy transforming cancer treatmentAre TCR-NK treatments the next big thing in cell therapies for cancer patients?As biotechs and pharma companies continue to innovate to address patient needs in oncology, T-cell receptor therapies, or TCR-Ts, are attracting significant interest and investment. There are already some promising results for TCR-Ts tackling solid tumors – but one Norwegian biotech is taking a slightly different track.This week, we sit down with Namir Hassan, CEO of Zelluna, a company with a mission to eliminate solid cancers by pioneering the development of T cell receptor guided natural killer, or TCR-NK, cell th...2025-05-0234 mintcr!tcr!Refresh the BatteriesRefresh the Batteries by tcr!2025-01-2802 mintcr!tcr!Orchestra FantastikOrchestra Fantastik by tcr!2024-10-3004 mintcr!tcr!confront your feelingsconfront your feelings by tcr!2024-09-1903 mintcr!tcr!soundtrack 1936soundtrack 1936 by tcr!2024-09-1912 mintcr!tcr!the crowd almost went wildthe crowd almost went wild by tcr!2024-09-1901 mintcr!tcr!space drift sunshinespace drift sunshine by tcr!2024-09-1805 mintcr!tcr!steam locomotive musicalsteam locomotive musical by tcr!2024-09-0506 mintcr!tcr!you're too good for meyou're too good for me by tcr!2024-09-0504 mintcr!tcr!pandemic violinspandemic violins by tcr!2024-09-0403 mintcr!tcr!slow mo milkweedslow mo milkweed by tcr!2024-08-3003 mintcr!tcr!house burning in black and whitehouse burning in black and white by tcr!2024-08-3001 mintcr!tcr!birds with pianobirds with piano by tcr!2024-08-3005 minAutoFM Programa del Motor y CochesAutoFM Programa del Motor y CochesAnalizamos como es la categorĂ­a de turismos de circuito TCR.Extracto del programa emitido en Onda Cero MS los jueves a las 19:20. QuĂ© es el TCR? -Se trata de un concepto de automovilismo de orden global. Tiene un Mundial avalado por la FIA y distintos certĂĄmenes regionales y nacionales. En total hay 35 campeonatos que utilizan este concepto. -El concepto TCR fue creado por el italiano Marcello Liotti en 2014 con el objetivo de crear un reglamento que garantizara costos razonables, competitividad entre las marcas y buen espectĂĄculo. -Una de las claves fue la similitud de los autos de pista con los de calle, saliendo de la tendencia hacia los pro...2024-07-2927 minS&S On BiotechS&S On Biotech3.9 The slow rise of TCR-T therapyWhen the first chimeric antigen receptor T-cell (CAR-T) therapy was approved in 2017, there was a general expectation that T-cell receptor T-cell (TCR-T) therapies would follow shortly afterwards and would greatly expand the range of addressable antigens. Despite considerable efforts, CAR-T therapies are still limited to haematological cancers expressing extracellular antigens, such as CD19 or B-cell maturation antigen (BCMA). Autologous TCR-T therapies can be engineered to target intracellular as well as extracellular peptide antigens presented on the cell surface by human leukocyte antigens (HLAs) and can be more readily used in solid tumors as well as in haematological c...2024-07-2936 mintcr!tcr!awayaway by tcr!2023-10-2904 mintcr!tcr!byebye by tcr!2023-10-2904 mintcr!tcr!13 flowers13 flowers by tcr!2023-10-2905 mintcr!tcr!vomitvomit by tcr!2023-10-2905 mintcr!tcr!tap dancetap dance by tcr!2023-10-2904 mintcr!tcr!concerto 9.12 w beezconcerto 9.12 w beez by tcr!2023-10-2903 mintcr!tcr!cold jazz fushioncold jazz fushion by tcr!2023-10-2907 mintcr!tcr!2laVe2laVe by tcr!2023-10-2904 mintcr!tcr!an alternaivean alternaive by tcr!2023-10-2904 mintcr!tcr!generate.bgenerate.b by tcr!2023-10-2902 mintcr!tcr!bastard.bbastard.b by tcr!2023-10-2907 minScience SocietyScience SocietyUnmasking Leukemia: The Role of MHC:TCR Signaling with Dr. LaffeyThis episode delves into the cutting-edge research of Dr. Laffey, who has been investigating the role of Major Histocompatibility Complex:T cell antigen receptor (MHC:TCR) signaling in the development of T cell tumors. While this signaling pathway is crucial for T cell development and immune responses, it can also trigger the formation of T cell tumors under abnormal conditions.Dr. Laffey's research focuses on a low-frequency progenitor cell population known as Early αÎČ TCR+ Double-Negative (EADN) cells. Present in both mice and humans, these cells can transform into thymic leukemia. His work has shown that EADN cells do...2022-09-091h 47tcr! diaries - podcasttcr! diaries - podcastBack to regular life content: Apr 19, 2019 · podcast: Jul 21, 2022 Audio (MP3): 20190419 - Back to regular life Do you know what I really hate? When somebody is being over-the-top nice after they’ve fucked something up. Do you know what I really like? When someone offers up a sincere apology and then gets on with the day. Own it. Regret it. Forget it. Take five minutes, have a real conversation, and then go back to regular life. If I don’t acknowledge I can come across like an unsym...2022-07-2100 minThe Creature ReportThe Creature ReportTCR_VPAL-ARCHIVAL_RECORDING_1023_SUBJECT1733CHARLES_SUBJECT964ADDISON_MISSINGSee you next week, Anchor.  ___________________________________ The Creature Report Documentation & Archival Assistant! What would you like to access? >recent files loading files...... Password protected area. Proceed with password: ************************ [Access Granted!] >TCR-VPAL-ARCHIVAL_RECORDING_0820_SUBJECT1740ARBY_MISSING >TCR-VPAL 27_AdditionalNotes >TCR-VPAL-ARCHIVAL_RECORDING_0829_SUBJECT1731TARTARUS_MISSING >TCR-VPAL-ARCHIVAL_RECORDING_0829_SUBJECT1428GRAWL_MISSING >TCR-VPAL 28_AdditionalNotes >TCR-VPAL-ARCHIVAL_RECORDING_0917_SUBJECT1742REPLACEDJEFF_FollowUp >The Creature Report: Episode 29, Utopic Dormihi...2021-10-2408 mintcr! diaries - podcasttcr! diaries - podcastI only fought with the police once content: Aug 22, 2018 · podcast: Sep 8, 2021 Audio (MP3): 20180822 - I only fought with the police once I only fought with the police once and there was only one of them. And it was 3 in the afternoon. And I was drunk and feisty. And then he tackled my 19 year old self in an alley and one side of my face ended up in some gravel. And then I went to jail with a swollen eye. And got to spend the rest of the evening sobering up. About 9pm or so and no longer drunk, I d...2021-09-0900 minThe Creature ReportThe Creature ReportTCR-VPAL_26_AdditionalNotesThe Creature Report Documentation & Archival Assistant! What would you like to access? >recent files loading files...... Password protected area. Proceed with password: ****************** [Access Granted!] >TCR-VPAL 19_AdditionalNotes >TCR-VPAL 20_AdditionalNotes >TCR-VPAL 21_AdditionalNotes >TherapeuticSession_05302021_Specimen905 >TCR-VPAL 22_AdditionalNotes >TCR-VPAL 23_AdditionalNotes >TCR-VPAL 24_AdditionalNotes >TherapeuticSession_07152021_Specimen1746 >TCR-VPAL 25_AdditionalNotes >TCR-VPAL 26_AdditionalNotes < >play  2021-08-1409 mintcr! diaries - podcasttcr! diaries - podcastMiracles are seen in light content: Apr 27, 2018 · podcast: May 6, 2021 Audio (MP3): 20180427 - Miracles are seen in light I fall short in life. That’s not a judgment call or me being hard on myself. It just is. I’m just another guy wandering around aimlessly doing my best
and sometimes doing my least. Struggling to maintain that non-mistake-making state only makes my life harder. Letting that struggle go gave me so much more free time to enjoy life and the company of my fellow humans. Well, I guess I never really expecte...2021-05-0600 minThe Cultural Reset (TCR)The Cultural Reset (TCR)An Interview with DEMIE CAO - 'The Cultural Reset' | Artist Interview Series - Episode #16This week’s episode of The Cultural Reset’s Artist Interview Series sees TCR’s Nick Lee and Shay Ervin speaking to Chinese-American songwriter/performer Demie Cao aka ‘Demie The Destroyer’. In this discussion, Demie reflects on her career beginnings—from her stint in ballet and K-Pop to her current love of hip-hop and live performance—and her thoughts on the branding limitations put on AAPI artists navigating the music industry. ... The Cultural Reset is a platform designed to uplift the voices of POC and LGBTQ+ artists through album reviews, artist interviews, and curated playlists. To see more of...2021-05-0342 minThe Cultural Reset (TCR)The Cultural Reset (TCR)An Interview with JASTIN ARTIS - 'The Cultural Reset' | Artist Interview Series - Episode #15In this newest entry of The Cultural Reset’s Artist Interview Series, TCR’s Nick Lee and Shay Ervin speak to DMV artist, Jastin Artis about his mission as an artist and his perspective on the expectations of artists in the music industry. From his thoughts on the industry’s treatment of genre-bending to his advice for all artists—both younger and mature—navigating the industry, Jastin shows the world his vision to reset the culture of music. ... The Cultural Reset is a platform designed to uplift the voices of POC and LGBTQ+ artists through album revi...2021-04-2252 minThe Cultural Reset (TCR)The Cultural Reset (TCR)An Interview with ROB MURAT - 'The Cultural Reset' | Artist Interview Series - Episode #14This latest entry of The Cultural Reset’s Artist Interview Series sees TCR’s Nick Lee and Shay Ervin speak to musician and Netflix’s ‘On My Block’ actor, Rob Murat. In an especially thought-provoking discussion, Rob and the team break down the differences between “inclusion” in TV/Film vs. music and the importance of creating a lasting space for people of color in entertainment. From his perspective on ‘creative trailblazing’ to his advice on navigating creative industries, Rob’s conviction to maintaining his integrity shines through in this intimate conversation.   ... The Cultural Reset is a platform design...2021-04-1437 mintcr! diaries - podcasttcr! diaries - podcastNobody can fuck with you content: Feb 12, 2018 · podcast: Mar 24, 2021 Audio (MP3): 20180212 - Nobody can fuck with you Remember that one time when you were younger? When nobody could fuck with you? Because everything had fallen into place. Because all the dots connected. Maybe your best friend was there. It doesn’t matter who you were with or how or when you got there. But that was it. That was the moment when you rose above the bullshit and realized you were more than what you had always felt. It was like you...2021-03-2400 minThe Cultural Reset (TCR)The Cultural Reset (TCR)An Interview with FELISHA GEORGE-'The Cultural Reset' | Artist Interview SeriesContinuing our programming for Women’s History Month 2021, TCR’s Creator and Editor-in-Chief, Nick Lee, and Assistant Director, Shay Ervin, spoke with rapper and bonafide “Word Magician”, Felisha George. As an alum of Netflix’s Rhythm and Flow, Felisha George speaks about her experience on the show as well as her personal journey as a queer-female artist navigating the hip-hop genre. In an intimate discussion, George touches on the importance of control over one’s brand as a woman and her thoughts on the unrealistic standards placed on women in rap-music. --- Support this podcast: https://anchor.fm/the-cultural...2021-03-1944 minThe Cultural Reset (TCR)The Cultural Reset (TCR)An Interview with TYLER SIMONE-'The Cultural Reset' | Artist Interview SeriesIn honor of Women’s History Month, this installment of The Cultural Reset’s Artist Interview Series sees TCR’s Nick Lee and Shay Ervin sit down with Tyler-Simone Molton, the lead singer of new wave/punk band Lesibu Grand. In an enlightening discussion, Tyler touches on the very personal inspiration behind her artistry as well as her dedication to authentic self-expression as a black woman in the music industry and her love of the unconventional. --- Support this podcast: https://anchor.fm/the-cultural-reset/support2021-03-0337 minThe Cultural Reset (TCR)The Cultural Reset (TCR)An Interview with NIAMBI RA-'The Cultural Reset' | Artist Interview SeriesIn this newest installment of The Cultural Reset's Artist Interview series, Creator Nick Lee and Assistant Director, Shay Ervin, sit down with Afro-futurist rapper, singer/songwriter Niambi Ra. A queer, black woman navigating a music career in Hip-Hop, Niambi speaks to TCR on the importance of artistic mentorship for artists of color, how her creative instinct intertwines with social activism, and remaining a music change-maker despite industry pressures for conformity. --- Support this podcast: https://anchor.fm/the-cultural-reset/support2021-02-281h 14The Cultural Reset (TCR)The Cultural Reset (TCR)An Interview with MAYA J-'The Cultural Reset' | Artist Interview SeriesThe Cultural Reset kicks off Black History Month with an intimate interview with singer and actress Maya J. TCR’s Nick Lee and Shay Ervin sat down with Maya to discuss her new single ‘Trouble’ as well as her experience navigating the ups and downs of the entertainment industry as a female artist. From her unique perspectives on artist-label relationships to her pledge to always create outside of the box, Maya dishes on the importance of maintaining artistic integrity in an era of oversaturation in music. --- Support this podcast: https://anchor.fm/the-cultural-reset/support2021-02-0345 minThe Cultural Reset (TCR)The Cultural Reset (TCR)An Interview with MDL CHLD-'The Cultural Reset' | Artist Interview SeriesIn another eye-opening entry of The Cultural Reset’s Artist Interview Series, TCR’s Nick Lee and Shay Ervin, sat down with Artist/ASL Interpreter/Tarot Reader Chris Corsini, AKA MDL CHLD, to chat about music inclusivity for deaf audiences. In an incredibly compelling discussion, Chris opens up about his efforts to create art with deaf people in mind, his mission to revolutionize the industry for deaf music-lovers, and the industry disparities that exclude the deaf from fully enjoying live performances. --- Support this podcast: https://anchor.fm/the-cultural-reset/support2021-01-2746 minThe Cultural Reset (TCR)The Cultural Reset (TCR)An Interview with MEL SEMÉ-'The Cultural Reset' | Artist Interview SeriesA former contestant on The Voice: Spain and a multi-talented, classically trained musician, The Cultural Reset's Artist Interview Series is pleased welcome Mel SemĂ© to the roster. In a beautifully vulnerable interview, TCR's leads Nick Lee and Shay Ervin spoke with Mel about his childhood musical roots, the story of his mother's passing, his spontaneous artistic process and navigating the music industry as an independent artist. --- Support this podcast: https://anchor.fm/the-cultural-reset/support2021-01-1345 mintcr! diaries - podcasttcr! diaries - podcastSteam Locomotive Musical content: Jan 11, 2021 Video (MP4): 20210111 - Steam Locomotive Musical Audio (MP3): 20210111 - Steam Locomotive Musical Here we have a 1930s steam locomotive with drums, an upright bass, a couple of pianos, and a string section. The original video was over 18 minutes long so I chopped and rearranged to fit the music I put together. I guess this is the kinda thing I do in a pandemic. I had originally planned for the music to go with some winter driving footage but that didn’t pan out. When I came across Ne...2021-01-1100 minThe Cultural Reset (TCR)The Cultural Reset (TCR)An Interview with LEX-'The Cultural Reset' | Artist Interview SeriesThis empowering entry of The Cultural Reset's Artist Interview Series sees TCR heads Nick Lee and Shay Ervin speaking with genre-bending vocalist and musician, LEX. In a beautifully revealing interview, LEX speaks about the intention behind her newest album release 'Bits and Pieces' and the personal tragedy that inspires her on her path toward self-actualization and awareness. --- Support this podcast: https://anchor.fm/the-cultural-reset/support2021-01-0945 mintcr! diaries - podcasttcr! diaries - podcastHouse Burning in Black and White content: Dec 30, 2020 · podcast: Jan 1, 2021 Audio (MP3): 20201229 - House Burning in Black and White Video (MP4): 20201229 - House Burning in Black and White A few piano melodies while a house burns in black and white đŸŽčđŸ”„đŸ  Reminds me of the lower end of the Peanuts theme in certain parts. #diariespodcast #diariesvideo JFK Clone High · Dec 30, 2020 at 4:44 pm Hey is it okay if I use this video on my channel? It’s gonna be the same thing but a different shade $m.wand.ajax_click=true;$m...2021-01-0100 mintcr! diaries - podcasttcr! diaries - podcastPandemic Violins content: Dec 26, 2020 Video (MP4): 20201226 - Pandemic Violins Audio (MP3): 20201226 - Pandemic Violins It's winter in a pandemic. It's Christmas time. I'm on vacation. I sit and write and record music. After listening to The Beatles sing about Eleanor Rigby on a two hour loop, I got hooked on violins stabbing and stomping about. The music sounds best with headphones. Nothing happens in the video. I needed something visual because most of the social medias don't do just audio. The footage is public domain and fairly boring. đŸŽ¶đŸŽ» #diariespodcast #diarie...2020-12-2700 minThe Cultural Reset (TCR)The Cultural Reset (TCR)An Interview with SHENNA-'The Cultural Reset' | Artist Interview SeriesA new addition to The Cultural Reset's Artist Interview Series, indie-pop sensation Shenna sits down with TCR's Nick Lee and Shay Ervin for a lively discussion of her career journey. From moving to NYC at the age of 17 to reinventing the pop genre for women of color, Shenna gives TCR an in-depth rundown of how she is unapologetically breaking down barriers in music. --- Support this podcast: https://anchor.fm/the-cultural-reset/support2020-12-1237 minThe Cultural Reset (TCR)The Cultural Reset (TCR)An Interview with ARIA WUNDERLAND-'The Cultural Reset' | Artist Interview SeriesThis week's entry of The Cultural Reset's Artist Interview series sees Nick Lee and Shay Ervin sit down with Alternative-Pop revolutionary Aria Wunderland. Aria joins TCR to discuss how quarantine has shaped her music-making process, the industry stereotypes used to stifle creatives, and how independent artists are working to reset the music industry's landscape. --- Support this podcast: https://anchor.fm/the-cultural-reset/support2020-12-0544 mintcr! diaries - podcasttcr! diaries - podcastBirds with piano content: Nov 27, 2020 Audio (MP3): 20201127 - Birds with piano Video (MP4): 20201127 - Birds with piano If you need to relax after your Black Friday, please enjoy a little piano and birds in my bird bath. Being November in Illinois the birds won't get to do this much longer. #diariespodcast #diariesvideo #naturerocks đŸŽč 🔊 alps · Nov 27, 2020 at 8:26 pm I’ve been getting 3 kinds of woodpeckers going to my feeder then bluejays, and cards. I could watch all day. 💯 $m.wand.ajax_click=true;$m.wand.lightswitch=true; ...2020-11-2800 minThe Cultural Reset (TCR)The Cultural Reset (TCR)An Interview with JAZZY MEJIA-'The Cultural Reset' | Artist Interview SeriesThis installation of The Cultural Reset's Artist Interview Series turns its focus to Pop/R&B singer/producer Jazzy Mejia. A teen icon and former member of internationally renown girl-group G.R.L., Jazzy Mejia sat down with TCR's Nick Lee and Shay Ervin to discuss her complicated transition from girl-group stardom to independent artist, the loved ones that inspire her creative process and growing up in and navigating the music industry as a woman of color. --- Support this podcast: https://anchor.fm/the-cultural-reset/support2020-11-2142 minThe Cultural Reset (TCR)The Cultural Reset (TCR)An Interview with NADIA TEHRAN-'The Cultural Reset' Artist Interview SeriesIn a new, particularly intimate entry of The Cultural Reset's Artist Interview Series, TCR's Creator/EIC Nick Lee, and Assistant Director, Shannon (Shay) Ervin, sat down with Iranian-Swedish rapper and songwriter, Nadia Tehran. Known for the personal and political themes that govern her work, Nadia joins TCR to deconstruct her most-recent album 'Dozakh: All Lovers Hell' as well as discuss her artistic inspiration, her creative paths, and her experience as a woman of color navigating the injustices of the music industry. --- Support this podcast: https://anchor.fm/the-cultural-reset/support2020-11-1429 mintcr! diaries - podcasttcr! diaries - podcastSlow Mo Milkweed content: Nov 9, 2020 Video (MP4): 20201108 - Slow Mo Milkweed Audio (MP3): 20201108 - Slow Mo Milkweed On weekends when I don't have Maggie I often pretend like I'm a cinematographer who knows how to play the piano. I also had Milkweed seeds all over my face when I was done. đŸŽč đŸŽ„ #diariespodcast #diariesvideo gracey · Nov 9, 2020 at 3:00 pm That was beautiful $m.wand.ajax_click=true;$m.wand.lightswitch=true; tcr! · Nov 9, 2020 at 3:11 pm thank you so much! $m.wand.ajax_cli...2020-11-0900 mintcr! diaries - podcasttcr! diaries - podcastRainy day bug ride content: Oct 28, 2020 Video (MP4): 20201018 - Rainy day bug ride In their downtime some people like to watch sports. Some people like to sew. Some people like to forage for frogs while frolicking in the forest. I like to pretend I’m a medieval composer while Maggie puts on her cinematographer cap and we’re driving around town in the sprinkling rain. #diariespodcast #diariesvideo #maggie jimi hindrance experience · Oct 28, 2020 at 2:06 pm Liked it. Holy Guacamole that’s a sweet bug! $m.wand.ajax_click=true;$m.wand.lightsw...2020-10-2800 mintcr! diaries - podcasttcr! diaries - podcastBreak On Through by The Doors content: Dec 1, 2017 · podcast: Aug 14, 2020 Audio (MP3): 20171201 - Break On Through by The Doors https://www.youtube.com/watch?v=rOpQjD-rX0g Peeps, here’s your the-gate-is-straight Friday jam. Listening to The Doors when I was 9 and 10 opened up my musical world so much more than bands like the Beatles did. Don’t get me wrong, I love yellow submarines as much as the next u-boat commander but I met the darkly cool poet persona in songs like The End and Waiting for the Sun. I became all too familiar with the torture of lo...2020-08-1400 mintcr! diaries - podcasttcr! diaries - podcastSmelling like coffee and Captain Morgan content: Jul 6, 2017 · podcast: Jul 30, 2020 Audio (MP3): 20170706 - Smelling like coffee and Captain Morgan One time I was driving to work on a hot summer morning. Just like today. Hung over pretty bad and nursing a pint of rum. I was in complete agony, had a fiery headache, and starting to sweat because my truck didn't have air conditioning. Taking shots now and then while auto-piloting the blue Ranger along the river. I needed just enough liquor to bring my headache down to a manageable level so I could make it through until lunch. 2020-07-3000 mintcr! diaries - podcasttcr! diaries - podcastNo reason for me to be in a hurry content: Aug 9, 2017 · podcast: Jul 26, 2020 Audio (MP3): 20170809 - No reason to be in a hurry Sometimes I got something going on, something I’m burning too much daylight on, and I can’t figure it out. The path isn’t clear. The monkey chatter is as loud as it gets and I feel myself ratcheting up. One time way back in high school I was struggling with a drawing. When I asked my art teacher for help she told me that I’d overworked it. And she was right, plain as day, clear as mud. I...2020-07-2600 mintcr! diaries - podcasttcr! diaries - podcastVirtual Bunker Tour content: May 17, 2020 Video (MP4): 20200517 - Virtual Bunker Tour Please enjoy a view from the futon in the office bunker. #diariesvideo #basement jenkins_arts · May 17, 2020 at 2:41 pm Excellent! $m.wand.ajax_click=true;$m.wand.lightswitch=true; tcr! · May 17, 2020 at 5:22 pm Yes and no 😊 $m.wand.ajax_click=true;$m.wand.lightswitch=true; jimi hindrance experience · May 17, 2020 at 8:08 pm The Hunker Bunker $m.wand.ajax_click=true;$m.wand.lightswitch=true; Uncle Timmy · May 17, 2020 at 10:06 pm 2020-05-1700 mintcr! diaries - podcasttcr! diaries - podcast100 percent decent content: May 2, 2019 · podcast: Apr 11, 2020 Audio (MP3): 20190502 - 100 percent decent You guys remember when Bill and Ted said, “be excellent to each other.” I loved that line and that movie but being excellent all the time is hard. Like I’m driving and some fuckwad cuts me off, and then comes to a near complete stop when turning right. Excellence is the about the last thing in my fingertips. Put them in the iron maiden đŸ€˜ You guys know about washing machines and when they agitate clothes. I can feel a...2020-04-1100 mintcr! diaries - podcasttcr! diaries - podcastDesperately Seeking Cup of Water content: Sep 24, 2018 · podcast: Apr 5, 2020 Video (MP4): 20180924 - Desperately Seeking Cup of Water Audio (MP3): 20180924 - Desperately Seeking Cup of Water I would get one myself but I’ve just settled in for my late afternoon nap. I don’t need a full glass, a full cup will do. I know you’ve been there: partially parched and close to near death as your bones wither down to the marrow. Plastic cups with the Millennium Falcon are preferred. Thor artwork will do. Toy Story cartoons are forbidden. Pleas...2020-04-0500 mintcr! diaries - podcasttcr! diaries - podcastsometimes you want something so bad content: Sep 5, 2019 · podcast: Mar 27, 2020 Audio (MP3): 20190905 - sometimes you want something so bad Video (MP4): 20190905 - sometimes you want something so bad Peeps, you know how sometimes you want something so bad. Think about it day after day, get angry and frustrated because nothing changes
 I get it. I’ve had my fair share of being stuck in jobs, relationships, stuck in some kind of mud. But trust me when I say that good things are being sorted out in the background. Too often it takes a long mother-clucking time...2020-03-2700 mintcr! diaries - podcasttcr! diaries - podcastUnrelenting Happiness content: Apr 15, 2012 · podcast: Mar 6, 2020 Audio (MP3): 20120415 - Unrelenting Happiness Feelings need not always be put into words. They can just be felt, like tigers or butterflies, snake bites or feline purrs. After they're done (and even if they're not), open your heart to the love, to the glow of the Universe. It's there waiting and it's yours. It's your right, your entitlement and a perquisite to unrelenting happiness. #lettherebehope #diariespodcast tcr! · Apr 15, 2012 at 11:01 am Drinking from that cup embraces us with a power that withers all evil sp...2020-03-0600 mintcr! diaries - podcasttcr! diaries - podcastNo horse blankets content: Apr 10, 2019 · podcast: Jan 18, 2020 Audio (MP3): 20190410 - No horse blankets When I got to the place where I couldn’t stand myself anymore, where I didn’t want to be the person I’d always been. And not do the same things I’d always done, I can see now that’s when I had reached the breaking point. The pain of being me had broken my very soul. Fuck. It wasn’t the drinking, it wasn’t ever the drugs. It was me. It wasn’t the traffic or the ot...2020-01-1800 mintcr! diaries - podcasttcr! diaries - podcastA backlog of taxes content: Nov 12, 2018 · podcast: Jan 12, 2020 Audio (MP3): 20181112 - A backlog of taxes I spent the majority of my adult life either toiling around to get my head on straight or hiding in the shadows from the truth. A backlog of taxes and overdue books. Pull up a little bit farther at the red light because I don’t want to look at the dude next to me. It’s not that I didn’t wanna go to college. It’s just that my ship was listing and the captain was drunk...2020-01-1200 mintcr! diaries - podcasttcr! diaries - podcastInwardly summiting a spiritual Mt Everest content: Dec 29, 2019 · podcast: Jan 11, 2020 Audio (MP3): 20191229 - Inwardly summiting a spiritual Mt Everest Seeking equality, fairness, the greater good...that does something remarkable for me. It breaks my selfish bubble. It makes me a whole human being. It gives me freedom. But wait, there’s more. So much more. Seeking balance and harmony for all...brings me out of my despair. It brings light to my darkness. It brings healing to my pain. It lifts me up and out of feeling down and blue, up to the level of okay I w...2020-01-1100 mintcr! diaries - podcasttcr! diaries - podcastdiaries for 2018 - book now available content: Apr 29, 2019 Audio (MP3): 20190429 - diaries for 2018 - book now available After all my moaning my 2018 diaries book is now ready to be put in your shopping carts. If you have an unfulfilled diaries magazine subscription don’t buy the book. Your paperback will be in the mail soon. The ones available here on the site are autographed, too. Paperback and Kindle editions are available on Amazon, non-autographed of course. You should buy my book. And then tell your friends about it. And share it on social media, as...2019-04-2900 mintcr! diaries - podcasttcr! diaries - podcastPillsbury's Candy Apple frosting content: Oct 14, 2018 · podcast: Apr 18, 2019 Audio (MP3): 20181014 - Pillsbury's Candy Apple frosting Sometimes I’ll got out on a culinary limb. A daring yet delectable escapade, laying out loads of cash for adventurous taste combinations that send the conservatives repulsed to the bakeries of safety. For example, in this year of 2018, this month of October, I dropped Candy Apple frosting from Pillsbury into my basket, impromptu style while in the aisles of Blue Goose. A one-handed yet non-acrobatic feat that impressed shoppers clear yonder to the western deli department. Bas...2019-04-1800 mintcr! diaries - podcasttcr! diaries - podcastDo you ever wake up cranky for no good reason? content: Sep 28, 2018 · podcast: Mar 14, 2019 Audio (MP3): 20180928 - Do you ever wake up cranky for no good reason? And then when you’re walking down the stairs you say “fuck those guys” but there are no guys there? And then when you’re standing in the kitchen getting your lunch ready you see a teeny purple flower on the floor and say “get the fuck out of here” and kick it under the stove? And then Alexa plays Kiss Me Deadly and then you think to yourself “Why does Ozzy get to hold heaven...2019-03-1400 minTest & CodeTest & Code68: test && commit || revert (TCR) - Thomas DeniffelWith conventional TDD, you write a failing test, get it to pass, then refactor. Then run the tests again to make sure your refactoring didn't break anything. But what if it did break something? Kent Beck has been recommending to commit your code to revision control after every green test run. Oddmund StrĂžmme suggested a symmetrical idea to go ahead and revert the code when a test fails. Kent writes that he hated the idea, but had to try it. Then wrote about it last September. And now we have TCR, "(t...2019-03-1338 min@Autoweird.fm@Autoweird.fmFolge 57: TCR - test/commit/revert (aka. hacks noch einmal Sam!) Da war doch was in der Timeline? Mal wieder eine neue AbkĂŒrzung! Von der alle reden! ALLE! Jetzt mĂŒssen wir doch auch mal schauen, was es damit auf sich hat. Die Rede ist natĂŒrlich(tm) von TCR – oder test && commit || revert, einer verschĂ€rften Abwandlung von TDD. Es geht darum, Code automatisch zu committen falls die Tests grĂŒn sind und wegzuwerfen, falls nicht. Abgefahren! Ja, so ganz passt das nicht mit der TDD-Abwandlung, TCR hat da noch andere Zielsetzungen (wir greifen mal wieder vor). „Aber Leute die TDD mögen, mögen auch“ 
...2019-02-241h 13tcr! diaries - podcasttcr! diaries - podcasttcr! diaries podcast survey content: Aug 24, 2018 · podcast: Jan 30, 2019 Audio (MP3): 20180824 - Podcast Survey I’m interrupting the regularly scheduled episodes to announce a listener survey created by yours truly. It’s informal and there won’t be a test later. And I love your feedback! It’s also quick and should take you less than 30 seconds. Go now: tcrbang.com/form/podcast_survey/ On with the show. #tcr #webdev #diariespodcast Add a comment! Got 30 seconds? Take the super duper, quick and easy podcast survey! Please. 😊...2019-01-3000 mintcr! diaries - podcasttcr! diaries - podcastShare the road with bikes? content: Jun 14, 2018 · podcast: Dec 7, 2018 Audio (MP3): 20180614 - Share the road with bikes? How about they go the speed limit? Or obey the traffic signals? Or decide if they’re going to be on the street or the sidewalk? I ride my bike as much as anybody. Okay, that’s not true. I have a bike in my garage and I’ve only ridden a few times this year. But I’ve seen the guy at Sammy’s Bikes race around town, blow through stop signs, make wild ass turns without warning, we...2018-12-0700 mintcr! diaries - podcasttcr! diaries - podcastA frantic game of animal tag content: Jun 11, 2018 · podcast: Dec 2, 2018 Audio (MP3): 20180611 - A frantic game of animal tag On this morning, the 11th of June I was greeted with a squeaky chipmunk in the basement just as I sat down with my first cup of coffee. It filled my heart with joy as the two H-Ks (hunter killers) and a lone chipmunk played a frantic game of animal tag. A frenzied game of hide and seek if you will. Where if you lose needly claws hooked to hair trigger tendons pulled by honed muscles will rip into y...2018-12-0200 minCAR-TCAR-TTCR engineeringWe have high qualified groups and advanced technologies to perform TCR engineering services covering every unit of manufacturing and delivery pipeline. From a tumor-reactive T cell or active anti-tumor T-cell antigens, the appropriate target sequence is introduced to modify T cells to target a broad range of tumors with improved specificity. With engineering TCR construction and a series of assay, such as transgene expression, TCR/CD3 stability, lymphocyte antigen reactivity and cytotoxicity, animal experiments, etc., we provide cGMP-compliant TCR products for preclinical and clinical trials. Learn more about TCR T cells. https://www.creative-biolabs.com/car-t/cellrapeutics-tcr-technology.htm2018-11-2900 mintcr! diaries - podcasttcr! diaries - podcastSaturated, colorful clematis content: May 18, 2018 · podcast: Nov 8, 2018 Audio (MP3): 20180518 - Saturated, colorful clematis And on this 18th day of May nature said lettuce have more flowers, specifically the saturated, colorful clematis. And the peeps of the world drew in a beautiful breath and embraced the brilliance. And then on a related note the man said, “If life is fleeting then that is irrelevant. In this minute let life’s focal point be the vibrancy.” #photos #flowers #diariespodcast jimi hindrance experience · May 18, 2018 at 9:45 am Holy shit, who is the a...2018-11-0800 minIl podcast di Motorsport Republic+Il podcast di Motorsport Republic+Intervista Marcello Lotti: WTCR, E-TCR. La crescita inarrestabile del Turismo da corsaMarcello Lotti era il manager esecutivo del WTCC (il Campionato Mondiale Turismo). Circa cinque anni fa per una serie di manovre al vertice organizzativo della Categoria del Turismo lui esce di scena e si mette subito al lavoro su una idea di vettura nuova, su un nuovo regolamento. Obiettivo: rilanciare una specialitĂ  in crisi per costi e, quindi, partecipazioni. Tre anni fa lanciĂČ il TCR e oggi, alla vigilia della quarta stagione, il TCR diventa lo standard mondiale della Categoria Turismo. Un successo inarrestabile che conta oltre 50 Paesi dove si corrono i Campionati Nazionali secondo la regola TCR e un Ca...2018-03-3034 minIl podcast di Motorsport Republic+Il podcast di Motorsport Republic+Intervista Marcello Lotti: WTCR, E-TCR. La crescita inarrestabile del Turismo da corsaMarcello Lotti era il manager esecutivo del WTCC (il Campionato Mondiale Turismo). Circa cinque anni fa per una serie di manovre al vertice organizzativo della Categoria del Turismo lui esce di scena e si mette subito al lavoro su una idea di vettura nuova, su un nuovo regolamento. Obiettivo: rilanciare una specialitĂ  in crisi per costi e, quindi, partecipazioni. Tre anni fa lanciĂČ il TCR e oggi, alla vigilia della quarta stagione, il TCR diventa lo standard mondiale della Categoria Turismo. Un successo inarrestabile che conta oltre 50 Paesi dove si corrono i Campionati Nazionali secondo la regola TCR e un Ca...2018-03-3035 minIl podcast di Motorsport Republic+Il podcast di Motorsport Republic+Intervista Marcello Lotti: WTCR, E-TCR. La crescita inarrestabile del Turismo da corsaMarcello Lotti era il manager esecutivo del WTCC (il Campionato Mondiale Turismo). Circa cinque anni fa per una serie di manovre al vertice organizzativo della Categoria del Turismo lui esce di scena e si mette subito al lavoro su una idea di vettura nuova, su un nuovo regolamento. Obiettivo: rilanciare una specialitĂ  in crisi per costi e, quindi, partecipazioni. Tre anni fa lanciĂČ il TCR e oggi, alla vigilia della quarta stagione, il TCR diventa lo standard mondiale della Categoria Turismo. Un successo inarrestabile che conta oltre 50 Paesi dove si corrono i Campionati Nazionali secondo la regola TCR e un Ca...2018-03-3035 mintcr! diaries - podcasttcr! diaries - podcastA get-together this coming Saturday content: Feb 17, 2018 · podcast: Mar 27, 2018 Audio (MP3): 20180217 - A get-together this coming Saturday I’m *thinking* about having a get-together this coming Saturday, February 24th. If you’re reading this you’re invited. It would be a social mixer of sorts with snacks and drinks. No, I’m not making you all dinner. Tater-tots could possibly be available. It would be kid friendly, too, since Maggie would also be hosting. Also, since you all know me you know that I don’t drink anymore. It’s not that I didn’t like drinking, it was more tha...2018-03-2700 mintcr! diaries - podcasttcr! diaries - podcastThrowing it on the floor content: Feb 11, 2018 · podcast: Mar 16, 2018 Audio (MP3): 20180211 - Throwing it on the floor I hate when I go to throw something away and then just end up throwing it on the floor. I mean, what the hell is this? It’s not like I’m threading the space shuttle needle in the vacuum of outer space. And then I forgot to put a dryer sheet in with my clothes so when I pulled them from the dryer, they all looked as if they were made from the hide of the great northern yeti. 2018-03-1600 mintcr! diaries - podcasttcr! diaries - podcastA cranberry stuck content: Feb 9, 2018 · podcast: Mar 9, 2018 Audio (MP3): 20180209 - A cranberry stuck The scene is my work desk. I'm eating cashew, almond, and cranberry trail mix. One of the cranberries jumped from the cup. I saw it happen but didn't hear the landing. After a mildly-extensive berry-hunt the fruit-trail gone-went cold. I cannot find the little asshole. I fear I may be walking around with a cranberry stuck on my ass for the rest of the day. I'm gonna power down my computer. Pack up my snacks, shave my head, braid my beard. Leave t...2018-03-0900 mintcr! diaries - podcasttcr! diaries - podcastHere's what happens when you unfriend someone content: Feb 2, 2018 · podcast: Mar 7, 2018 Audio (MP3): 20180202 - Here's what happens when you unfriend someone This showed up on my timeline just a little bit ago. So Facebook “noticed” I unfriended somebody. I highly doubt if they just “noticed” anything. They KNOW our every move people. They track and follow said movements even when we’re not on their website or using their apps. These social media overlords go so far as having shadow accounts of people that don’t have real, actual Facebook accounts. Oh yeah, it’s true. Your dead...2018-03-0700 mintcr! diaries - podcasttcr! diaries - podcastUnder Maggie's pillow content: Jan 9, 2018 · podcast: Feb 16, 2018 Audio (MP3): 20180109 - Under Maggie's pillow And then there was that one time maybe six or seven years ago when I ate a Snickers fun-size and hid the wrapper under Maggie’s pillow. And then at bedtime when we found it and she was horrified of being convicted of a crime she didn’t commit, after she had time to process and I confessed, she thought it was funny. And she still does. Because I asked her about it earlier tonight before dinner. “And you tri...2018-02-1600 mintcr! diaries - podcasttcr! diaries - podcastMaggie and I talk bacon content: Feb 2, 2018 Audio (MP3): 20180202 - Maggie and I talk bacon I picked Maggie up from her mom's and on a whim we did a quick, off the cuff podcast in my truck on the way back home. There's some background noise but that's what happens when you're recording while driving 45 mph. And yes, she was holding the phone and not me. Safety first kids. Also, neither of us had prepared for this. Spontaneity in all its glory. #maggie #diariespodcast prokop · Feb 2, 2018 at 5:49 pm 2018-02-0200 mintcr! diaries - podcasttcr! diaries - podcastWe don't want to spoil his suprise content: Sep 21, 2017 · podcast: Nov 22, 2017 Audio (MP3): 20170921 - We don't want to spoil his suprise In follow up to August 16th's Provocative yet professional #email #hirasfashion #diariespodcast keamoose · Sep 21, 2017 at 7:31 pm They did leave the door open for that with “and more”. Have you seen this? http://thebloggess.com/2017/01/04/im-gonna-be-a-vampire-maybe/ $m.wand.ajax_click=true;$m.wand.lightswitch=true; tcr! · Sep 22, 2017 at 6:58 am I hadn’t seen that but late last night I was all over it like a one-tooth...2017-11-2200 mintcr! diaries - podcasttcr! diaries - podcastAmazing blueberry jelly content: Oct 19, 2017 · podcast: Nov 1, 2017 Audio (MP3): 20171019 - Amazing blueberry jelly I hate it when I'm walking down the work hallway and I hear another office door open. Can't I just walk down the hall alone, with peace and quiet? Now matter how much I try to avoid people, some random body shows up and says, "hello." And then I have to quickly scan the mental rolodex for non-offensive chit-chat. Engage in dialogue that obviously won't last more than 15 seconds. It's not that I don't like the other office building inhabitants b...2017-11-0100 mintcr! diaries - podcasttcr! diaries - podcastMore knob twists content: Oct 27, 2017 · podcast: Nov 1, 2017 Audio (MP3): 20171027 - More knob twists I’m in the private, single person work restroom. Somebody tries the door knob. It refuses because I’m not an animal and therefore lock the door. Again, with the twisting. I scowl at the door. More knob twists. This time as if brute force will unlock the door. I’m annoyed now. Three seconds pass. The knob twists yet again. I call out forcefully, angrily... “dude, I’m taking a shit.” I don’t like talking to people in publi...2017-11-0100 mintcr! diaries - podcasttcr! diaries - podcastWhy are there so many pubes content: Sep 18, 2017 · podcast: Oct 17, 2017 Audio (MP3): 20170918 - Why are there so many pubes Why are there so many pubes in the damn urinals? What the hell are people doing in there? 🙄 #socialproblems #diariespodcast #publicrestroom tcr! · Sep 18, 2017 at 4:04 pm Mona mentioned on FB, “folks not getting enough vitamins.” So I made a sign
 $m.wand.ajax_click=true;$m.wand.lightswitch=true; Add a comment! Got 30 seconds? Take the super duper, quick and easy podcast survey! Please. 😊 Love the show? Make a donatio...2017-10-1700 mintcr! diaries - podcasttcr! diaries - podcastSunrise for Sep 27, 2017 content: Sep 27, 2017 · podcast: Sep 30, 2017 Audio (MP3): 20170927 - Sunrise for Sep 27 2017 Peeps, what was happening for me a few moments ago was a wonderful pinky orange sunrise. It’s Wednesday so we’re half-way through the week. Who can argue with hump day? NOBODY. That’s who. Also, I could really use Desperately Seeking Susan on DVD. Ya, it’s from the 80s but still holding 88% on the Tomatoes. Bonus: if you have the soundtrack on vinyl you’ll be invited to the masquerade ball next month. Don’t just say you got it, y...2017-09-3000 mintcr! diaries - podcasttcr! diaries - podcastWhat's Happening in Geneva, Facebook group content: Sep 24, 2017 · podcast: Sep 27, 2017 Audio (MP3): 20170924 - By the name a Thelma Louise I may need to leave the What's Happening in Geneva Facebook group. I keep wanting to help with my web expert advice, wit, and charm. Below are two examples that I could barely resist (but did). Hi there, I Need recommendation for washing machine fix.... thank You're gonna go all the way down about half a block and you'll see a Torino with no wheels on it. Now, inside that Torino is my cousin, Jackie. N...2017-09-2800 mintcr! diaries - podcasttcr! diaries - podcastJul 2nd, 2017 at 2:42:05 am content: Jul 2, 2017 · podcast: Sep 17, 2017 Audio (MP3): 20170702 - Starting tomorrow Starting tomorrow I will randomly and routinely wake the cats up during the day because, no matter how many times we talk about this, they continually wake me up in the middle of the night with their bullshit. And yes, when I do it will be in such a way as to scare them shitless. #cats #napsarespiritual #diariespodcast tcr! · Jul 2, 2017 at 4:38 pm I really want to scare her shitless but she’s on my leg and I worry ther...2017-09-1700 mintcr! diaries - podcasttcr! diaries - podcasttcr! diaries podcast now available content: Aug 21, 2017 · podcast: Sep 17, 2017 Audio (MP3): 20170821 - tcr diaries podcast now available So this is a thing now. Keep your expectations low. I mean like really low. I don't know if it'll be anything more than just an audio version of a written piece. We'll see how it goes. Maybe I'll ad-lib now and then. Maybe I'll play the piano. At this point I'm just trying to get used to the sound of my own damn voice. 😘 You can listen on iTunes And you can listen on SoundCloud And you can list...2017-09-1700 mintcr!tcr!20170816 - Morning drinks mute the fires of hell.mp320170816 - Morning drinks mute the fires of hell.mp3 by tcr!2017-08-1602 mintcr!tcr!20170813 - All Out of Love by Air Supply20170813 - All Out of Love by Air Supply by tcr!2017-08-1301 mintcr!tcr!20170810 - Seeking colorful Christian martyr to repel repeated Jehovah's Witness20170810 - Seeking colorful Christian martyr to repel repeated Jehovah's Witness by tcr!2017-08-1003 mintcr!tcr!20170804 - Slip Slide Melting by For Love Not Lisa20170804 - Slip Slide Melting by For Love Not Lisa by tcr!2017-08-0402 mintcr!tcr!i'm not a hybridi'm not a hybrid by tcr!2013-09-1005 minFakultĂ€t fĂŒr Biologie - Digitale Hochschulschriften der LMU - Teil 04/06FakultĂ€t fĂŒr Biologie - Digitale Hochschulschriften der LMU - Teil 04/06Recognition of renal cell carcinoma by CD8+ and CD4+ TCR-engineered T lymphocytesImmunotherapy using T cells is a new approach that is being explored for the treatment of metastatic melanoma. For renal cell carcinoma (RCC), adoptive T cell therapy (ATT) is currently hampered by the lack of T cells expressing suitable T cell receptors (TCR). A tumor-infiltrating T cell population (TIL) was identified in our group (TIL-53) that showed a pattern of tumor recognition consistent with the requirements of a TCR applicable for immunotherapy. With the advent of genetic TCR engineering it was possible to further define the TIL specificity which was previously precluded by the failure to cultivate TIL-53. To achieve...2011-02-2100 minJournal Club Imunoterapia TumoralJournal Club Imunoterapia TumoralEdição#8: Flexibilidade do CDR3 do TCR comprovada por cristalografia. ImplicaçÔes no reconhecimento antigĂ©nico pelos linfĂłcitos T.OlĂĄ malta! Neste oitava edição do Podcast Imunoterapia Tumoral apresento-vos o artigo de Gakamsky et al, publicado recentemente no jornal PNAS vol 104: 16639 de 2007. Este artigo vem pela primeira vez corroborar com dados de biofĂ­sica os dados apresentadas por vĂĄrios trabalhos baseados em cristalografia do complexo TCR/peptideo-MHC, e onde Ă© sugerida de o domĂ­nio do CDR3 Ă© capaz de uma certa mobilidade e capacidade de adaptar-se ("fiting") Ă  superfĂ­cie tri-dimensional do complexo peptĂ­deo-MHC. Para relembrar: o TCR Ă© o receptor da cĂ©lula T, que reconhece peptĂ­deos (oligopeptideos) apresentados pela molecula Major de Histocompatibilidade (MHC). As cĂ©lulas T sĂŁo de...2007-12-0818 min