Shows
Future Pulse CardiologyInflammation and Cardio-Rheumatology with Dr Nehal MehtaWe would love to hear your thoughts on the episodes!Dr Thomas Nero discusses inflammation adn specifically the role of rheumatologic disorders on coronary artery disease with Dr Nehal Mehta. This conversation delves into the intricate relationship between inflammation and cardiovascular disease, exploring how chronic inflammation serves as a cornerstone for various health issues, particularly in patients with conditions like psoriasis. The discussion highlights the role of immune responses, the impact of lifestyle factors, and the importance of early diagnosis and risk assessment in managing cardiovascular health. They discuss the complexities of inflammatory markers and their implications i...
2024-12-2652 minFuture Pulse CardiologyInflammation and Cardiovascular Disease with Dr Nehal MehtaWe would love to hear your thoughts on the episodes!In this conversation, Dr. Nehal Mehta and Dr. Thomas Nero discuss the critical relationship between systemic inflammation and cardiovascular health, particularly in patients with psoriasis. He emphasizes the importance of understanding how an overactive immune system can lead to increased risks of heart disease and other health issues. The discussion also covers lifestyle changes that can help manage inflammation, including diet, exercise, and mental health support.takeawaysSystemic inflammation can lead to cardiovascular disease.Psoriasis is linked to increased heart...
2024-12-1207 minFuture Pulse CardiologyCoronary Inflammation Imaging with FAI Score on CT angiography with Prof. Stefan NeubauerWe would love to hear your thoughts on the episodes!Prof. Stefan Neubauer and Dr. Thomas Nero discuss two recent papers on the utility of coronary inflammation imaging on CT coronary angiography with Fat Attenuation Index (FAI)FAI score. The ORFAN study demonstrated a 20 fold increased risk in CV event rates with low vs high FAI score and a 10 fold increased event rate in patients with elevated FAI score who have no coronary plaque. FAI score re-categorized 40% of patients in their follow-up studies.Prof. Neubauer is the head of the Division of Cardiovascular M...
2024-06-2345 minFuture Pulse CardiologyTrial Statistics, Trial Design and AI with Dr. C Michael GibsonWe would love to hear your thoughts on the episodes!Dr Gibson and Dr Nero discuss the oft maligned issue of medical statistics. Their discussion covers the pros and cons of traditional Cox proportional hazards regression models and Kaplan-Meier curves and newer techniques including win ratios. They then dip their toes into AI. A great overview by one of our leading clinical trialists.
2024-02-2934 minFuture Pulse CardiologyDeep Dive into Lp(a) with Dr Steven Nissen Part 2 of 2We would love to hear your thoughts on the episodes!This episode is a deep dive into Lipoprotein a with Dr Steven Nissen from the Cleveland Clinic. He and Dr Nero discuss the genetics of Lp(a), its pathophysiology, current treatment strategies and research into lowering Lp(a) levels. This is a fascinating conversation that also discusses the role of coronary inflammation in the work of Dr. Paul Ridker as well as the role of CT angiography in future clinical trials.
2024-02-1948 minFuture Pulse CardiologyLp(a): a basic clinical approach with Dr. Steven Nissen Part 1 of 2We would love to hear your thoughts on the episodes!Dr Steven Nissen from the Cleveland Clinic discuses with Dr. Thomas Nero the basic clinical approach to Lp(a) with need for routine testing and a few simple case studies. In the second (longer podcast) they take a deep deep dive into Lp(a) genetic, pathophysiology and the current research trials.
2024-02-1411 minFuture Pulse CardiologyCoronary Artery Disease in the Endurance Athlete with Dr Aaron BaggishWe would love to hear your thoughts on the episodes!Dr Thomas Nero speaks with Dr Aaron Baggish about coronary artery disease in the endurance athlete (and non-athlete as well!) They discuss cardiovascular testing in Masters athletes including ETT, coronary calcium scoring and CT angiography as well as risk factor identification, inflammation, physical & emotional stress and ongoing research. Dr Baggish is a Professor of Sports Cardiology at Université de Lausanne and founder of the Cardiovascular Performance Program, Massachusetts General Hospital, Harvard Medical School. He has been team cardiologist for USA rowing, US Soccer, and the New England Patri...
2024-02-0141 minFuture Pulse CardiologyAtrial Fibrillation and Clinical Trials with Dr John MandrolaWe would love to hear your thoughts on the episodes!Dr Mandrola discusses recent trail data with Dr. Thomas Nero including the results from Artesia, NOAH Afnet 6, Frail AF, Azalea and Oceanic-AF. They also discuss Left Atrial Appendage Occlusion and utility of wearable devices. Finally, a shout out to Dr. Andre Foy and his work on multi-morbidity and its role in clinical trial interpretation.
2023-12-2648 minFuture Pulse CardiologyCoronary Calcium Score and CT Coronary Angiography with Dr. Mathew BudoffWe would love to hear your thoughts on the episodes!Dr. Thomas Nero speaks with Dr. Mathew Budoff about Coronary Calcium Scoring, CT Coronary Angiography and cardiovascular outcomes. The discussion goes beyond basic risk factor enhancement, highlighting its role to help evaluate disease progression, power future clinical trials and determine efficacy of therapy. Along the way, they discuss coronary inflammation, perivascular adipose tissue imaging and fat attenuation index (FAI) as well as diving into the plaque stabilizing effects of EPA.
2023-12-0324 minFuture Pulse CardiologyDr Elizabeth Ofili and The African American Heart StudyWe would love to hear your thoughts on the episodes!Dr. Elizabeth Ofili discusses the African American Heart Study with Dr. Thomas Nero. They also discuss her work at the NIH and the African American Heart Failure Trial and the role of community based pragmatic clinical trials.
2023-11-2634 minFuture Pulse CardiologyAnticoagulation, Thombin Generation and Factor XI inhibition in ACS and Atrial Fibrillation with Dr C. Michael GibsonWe would love to hear your thoughts on the episodes!Dr. Thomas Nero discusses current therapy with Factor X inhibitors, the new research with Factor XI inhibition and specifically the enrolling Milvexian clinical trials with Dr. C Micahel Gibson. In addition they discuss, the addition of these medications along wiht anti-platelet therapy, Lp(a) and other interesting current and future research in cardiovascular disease.
2023-06-2530 minFuture Pulse CardiologyDiabetes and Cardiovascular Disease, SGLT2 inhibitors and GLP1 receptor agonists with Dr. Peter TothWe would love to hear your thoughts on the episodes!Dr. Thomas Nero speaks with Dr Peter Toth about the dramatic change occuring in diabtetes management and its effect on cardiovascular disease. Starting with the biochemestry of diabetes and its effects at the cellular level, the discussion goes on to speak about the role SGLT2 inhibitors and GLP1 receptor agonists play in DM management as well as the future of diabetes care. (If you want to skip the excelllent, but quite deep dive into biochemistry, jump to 11:22 - but honestly Dr. Toth's description is breathtaking)
2023-05-0445 minFuture Pulse CardiologyLipids, Lipid Sub-fractionations and Inflammation, Putting It All Together with Dr Peter TothWe would love to hear your thoughts on the episodes!Dr. Thomas Nero speaks with Dr. Peter Toth about the complex biology of lipids and atherosclerosis. In this episode Dr Toth dives into LDL goals, therapies for attenuating non-LDL risk, vascular biology and the where are research studies lead us in choosing therapies.
2023-04-1634 minFuture Pulse CardiologyInflammation and Coronary Artery Disease with Dr Paul RidkerWe would love to hear your thoughts on the episodes!Dr Paul Ridker discusses his paper on residual inflammatory risk that was recently published in the Lancet with Dr. Thomas Nero. He discusses the pathology of inflammation as part of atherosclerosis, utilization of hs-CRP in clinical trials and in daily practice as well as current therapeutic options and ongoing investigations.
2023-04-0940 minFuture Pulse CardiologyPragmatic Clinical Trials and EVOLVE-MI with Dr Christopher CannonWe would love to hear your thoughts on the episodes!Dr Christopher Cannon discusses the potential of Pragmatic Clinical Trials in our research armamentarium with Dr. Thomas Nero. They review the EVOLVE-MI trial for Early use of Evolocumab after Myocardial Infarction in detail and highlight the potential for future research.
2022-12-1221 minFuture Pulse CardiologySpontaneous Coronary Artery Dissection (SCAD) with Dr. Sharonne Hayes Part 1We would love to hear your thoughts on the episodes!Dr Sharonne Hayes of the May Clinic discusses SCAD with Dr. Thomas Nero. Initially focusing on the new treatment paradigms, their wide ranging discussion covers etiology, pathophysiology and potential future therapeutic options. Tis is the first of a two part podcast.
2022-08-2126 minFuture Pulse CardiologySpontaneous Coronary Artery Dissection (SCAD) with Dr. Sharonne Hayes Part 2We would love to hear your thoughts on the episodes!Dr Sharoanne Hayes and Dr. Thomas Nero continue their discussion of SCAD focusing on genetics, trial design and the role of online registries as well as the holistic treatment of the SCAD patient. This is part two of two.
2022-08-2123 minFuture Pulse CardiologyEvaluation of Coronary Inflammation with CT angiography and Fat Attenuation IndexingWe would love to hear your thoughts on the episodes!Dr. Nero discusses evaluation of coronary artery disease and coronary inflammaiton with Dr. Cheerag Shirodaria from the University of Oxford. Dr. Shirodaria along with Prof. Charalambos Antonidies at Caristo Diagnostics have developed a ground breaking technology that allows us to evaluate not just the severity of a coronary artery lesion, but also how inflamed it is and how likely it is to cause fatal and non-fatal myocardial infarction. In addition, since it is a biologically active "marker" the Fat Attenuation Index (FAI) can also be used a a w...
2022-05-0528 minFuture Pulse CardiologyLegal Aspects of FDA approval and implications for clinical researchWe would love to hear your thoughts on the episodes!Prof. Christine Coughlin of Wake Forest School of Law speaks with Dr. Thomas Nero on the FDA approval process, emergency use authorization, Right to Try Legislation and the implications for clinical research, diversity and health care equity. Prof. Coughlin holds positions in the College of Medicine as well as the Law school and in the Center for Bioethics. She has published extensively on the FDA approval process.
2022-04-2023 minFuture Pulse CardiologyEl colesterol y la Enfermedad CardiovascularComprender el colesterol es una parte importante para comprender su riesgo de enfermedad cardíaca y accidente cerebrovascular. El colesterol total se compone de LDL (colesterol malo), HDL (colesterol bueno) y triglicéridos (que también son malos). Dado que se compone de partes buenas y malas, el colesterol total puede ser engañoso. En este episodio, presentamos que es el colesterol, los motivos por los cuales se eleva y que podemos hacer para tratarlo.
2022-04-0112 minFuture Pulse CardiologyCoronary Artery Disease in the Athlete with Dr Paul ThompsonWe would love to hear your thoughts on the episodes!Although exercise usually provides a cardiovascular benefit, there is some data that points to an increase in event rates in extreme endurance athletes. In this episode, Dr. Thomas Nero and Dr. Paul Thompson discuss the surprising findings regarding coronary calcium, cardiac troponins and atrial fibrillation in the endurance athlete and some thoughts about ideas to pursue in future research.
2022-03-1123 minFuture Pulse CardiologyStatin Associated Muscle Symptoms with Dr Thomas Nero and Dr Paul ThompsonWe would love to hear your thoughts on the episodes!Dr Nero and Dr Thomposn discuss Statin Associated Muscle Symptoms (SAMS) and the results of the STOMP and SAMSON trials. In addition, they discuss statins and athletic training, options for the statin intolerant patient and research regarding further investigation of the ranitadine receptor among other topics
2022-03-0922 min
Future Pulse CardiologyCAD, Lipid Sub-fractionation and Lp(a) with Dr Paul ThompsonWe would love to hear your thoughts on the episodes!Our inaugural podcast is a discussion between Dr. Paul Thompson, Chief of Cardiology, Emeritus, at Hartford Hospital and Professor of Medicine, Emeritus, at University of Connecticut and Dr. Thomas Nero, Director of Cardiovascular Research at CAFC about coronary artery disease, lipid sub-fractionation and the role of lipoprotein a, aka Lp(a).
2022-03-0820 minFuture Pulse CardiologyFuture Pulse Cardiology TrailerWe would love to hear your thoughts on the episodes!I’m Dr Thomas Nero. At Future Pulse our goal is to investigate the future of cardiovascular research and promote that discussion. What is the next step and how will this trickle down to our clinical practice? What’s exciting and new in our field and why should we be interested. We will also look at the other side of the equation: how are we going to get these ideas off the ground? How are we going to make the transition from the...
2022-03-0701 min