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Showing episodes and shows of
Tom Jaramillo
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The Journal Club
Human CLOCK's Role in Cognitive Flexibility
Liu, Y., Fontenot, M.R., Kulkarni, A. et al. Human CLOCK enhances neocortical function. Nat Neurosci (2025)
2025-06-30
12 min
The Journal Club
Unlocked a New Method of Treating Alzheimer's Disease and other Cognitive Decline
Neuronal glycogen breakdown mitigates tauopathy via pentose-phosphate-pathway-mediated oxidative stress reduction
2025-06-30
14 min
The Journal Club
The Neural Circuit Governing Sleep Homeostasis
Lee SS, Liu Q, Cheng AHR, Kim DW, Boudreau DM, Mehta A, Keles MF, Fejfer R, Palmer I, Park KH, Münzberg H, Harris TD, Graves AR, Blackshaw S, Wu MN. Sleep need-dependent plasticity of a thalamic circuit promotes homeostatic recovery sleep. Science. 2025 Jun 19
2025-06-23
11 min
The Journal Club
Olfactory Bulb and Memory Dysfunction in Neuropsychiatric Disorders
Parbst F, Kostka JK, Günther A, Chen YN, Hanganu-Opatz IL, Bitzenhofer SH. Developmental Olfactory Dysfunction and Abnormal Odor Memory in Immune-Challenged Disc1+/- Mice. J Neurosci. 2025 Jun 18
2025-06-23
13 min
The Journal Club
SCN GRPNs: Modulatory Role in Circadian Photic Entrainment
Li R, Inoue R, Mori H, Hirano A, Sakurai T. Functional Roles of Gastrin-Releasing Peptide-Producing Neurons in the Suprachiasmatic Nucleus: Insights into Photic Entrainment and Circadian Regulation. J Neurosci. 2025 Jun 18
2025-06-23
16 min
The Journal Club
Hippocampal Ripples Decrease During Physical Actions in Rodents
Sakairi T, Kawabata M, Rios A, Sakai Y, Isomura Y. Hippocampal Sharp-Wave Ripples Decrease during Physical Actions Including Consummatory Behavior in Immobile Rodents. J Neurosci. 2025 Jun 18
2025-06-23
15 min
The Journal Club
DDX3X Mutations: Sex-Specific Effects on Brain Development
Mossa, A., Dierdorff, L., Lukin, J. et al. Sex-specific perturbations of neuronal development caused by mutations in the autism risk gene DDX3X. Nat Commun 16, 4512 (2025)
2025-06-21
18 min
The Journal Club
Autism and Social Avoidance: Neural Circuitry of Touch Discrimination
Chari, T., Hernandez, A., Couto, J. et al. A reduced ability to discriminate social from non-social touch at the circuit level may underlie social avoidance in autism. Nat Commun 16, 4600 (2025). https://doi.org/10.1038/s41467-025-59852-6
2025-06-20
12 min
The Journal Club
Autism associated Chd8 Gene Duplication and Neurodevelopmental Defects in Mice
Kawamura, A., Fujii, K., Tamada, K. et al. Duplication of the autism-related gene Chd8 leads to behavioral hyperactivity and neurodevelopmental defects in mice. Nat Commun 16, 4641 (2025). https://doi.org/10.1038/s41467-025-59853-5
2025-06-20
12 min
The Journal Club
Precision nutrition for Cardiometabolic Diseases
Guasch-Ferré, M., Wittenbecher, C., Palmnäs, M. et al. Precision nutrition for cardiometabolic diseases. Nat Med 31, 1444–1453 (2025)
2025-06-17
17 min
The Journal Club
Health impacts of exposure to synthetic chemicals in food
Muncke, J., Touvier, M., Trasande, L. et al. Health impacts of exposure to synthetic chemicals in food. Nat Med 31, 1431–1443 (2025)
2025-06-17
26 min
The Journal Club
How you breathe is like a fingerprint that can identify you
Soroka T, Ravia A, Snitz K, Honigstein D, Weissbrod A, Gorodisky L, Weiss T, Perl O, Sobel N. Humans have nasal respiratory fingerprints. Curr Biol. 2025 May 30
2025-06-17
13 min
The Journal Club
Microbiome Signatures of Parkinson’s Disease Revealed Through AI
Romano, S., Wirbel, J., Ansorge, R. et al. Machine learning-based meta-analysis reveals gut microbiome alterations associated with Parkinson’s disease. Nat Commun 16, 4227 (2025)
2025-06-17
21 min
The Journal Club
Climate Change Linked to Sleep Apnea
Lechat, B., Manners, J., Pinilla, L. et al. Global warming may increase the burden of obstructive sleep apnea. Nat Commun 16, 5100 (2025)
2025-06-17
18 min
The Journal Club
Neural Flexibility: A Possible Autism Intervention
Watanabe, T., Yamasue, H. Noninvasive reduction of neural rigidity alters autistic behaviors in humans. Nat Neurosci 28, 1348–1360 (2025)
2025-06-12
23 min
The Journal Club
How Exercise Rewires the Brain
da Rocha, J.F., Lance, M.L., Luo, R. et al. Protective exercise responses in the dentate gyrus of Alzheimer’s disease mouse model revealed with single-nucleus RNA-sequencing. Nat Neurosci (2025).
2025-06-12
17 min
The Journal Club
Why don’t bats get cancer?
Athar, F., Zheng, Z., Riquier, S. et al. Limited cell-autonomous anticancer mechanisms in long-lived bats. Nat Commun 16, 4125 (2025)
2025-06-12
12 min
The Journal Club
Psilocybin Remodels Cortical Neurons and Behavior
Shao, LX., Liao, C., Davoudian, P.A. et al. Psilocybin’s lasting action requires pyramidal cell types and 5-HT2A receptors. Nature 642, 411–420 (2025)
2025-06-12
16 min
The Journal Club
Why a Boy Could Not Feel Pain
CRISPR helps to show why a boy felt no pain. Nature. 2025 Jun;Antunes FTT, Gandini MA, Garcia-Caballero A, Huang S, Ali MY, Gambeta E, Souza IA, Harding EK, Ferron L, Stray-Pedersen A, Gadotti VM, Zamponi GW. A pathological missense mutation in the deubiquitinase USP5 leads to insensitivity to pain. J Exp Med. 2025 Aug 4
2025-06-12
11 min
The Journal Club
How to keep weight off after obesity drugs
Nature 11 June 2025 How to keep weight off after obesity drugs by Elie DolginRodriguez, P. J. et al. JAMA Netw. Open 8, e2457349 (2025).Eisenberg, D. et al. Surg. Obes. Relat. Dis. 18, 1345–1356 (2022)Itani, M. I. et al. Obes. Surg. 32, 381–390 (2022).Maselli, D. B. et al. Gastroenterology 167, 1457–1459 (2024).van Baar, A. C. G. et al. Diabetes Res. Clin. Pract. 184, 109194 (2022).Mingrone, G. et al. Gut 71, 254–264 (2022).Aronne, L. J. et al. JAMA 331, 38–48 (2024).Lundgren, J. R. et al. N. Engl. J. Med. 384, 1719–1730 (2021).Paddu, N. U., Lawrence, B., Wong, S., Poon, S. J. & Srivasta...
2025-06-12
13 min
The Journal Club
World first: brain implant lets man speak with expression ― and sing
Nature 11 June 2025 World first: brain implant lets man speak with expression ― and sing by Miryam NaddafSinger-Clark T, Hou X, Card NS, Wairagkar M, Iacobacci C, Peracha H, Hochberg LR, Stavisky SD, Brandman DM. Speech motor cortex enables BCI cursor control and click. J Neural Eng. 2025 May 14
2025-06-12
08 min
The Journal Club
Emergence and Development of a Gender Gap in Mathematics
Martinot, P., Colnet, B., Breda, T. et al. Rapid emergence of a maths gender gap in first grade. Nature (2025)
2025-06-12
22 min
The Journal Club
Changes in the auditory cortex of children receiving gene therapy for deafness.
Changes in the auditory cortex of children receiving gene therapy for deafness. Nat Hum Behav (2025).
2025-06-11
15 min
The Journal Club
How Single Neurons in the Amygdala and Hippocampus encode face identity
Cao, R., Wang, J., Lin, C. et al. Feature-based encoding of face identity by single neurons in the human amygdala and hippocampus. Nat Hum Behav (2025)
2025-06-11
16 min
The Journal Club
Identical Twins, Unequal Outcomes: The Genetics of Sensitivity
Assary, E., Coleman, J.R.I., Hemani, G. et al. Genetics of monozygotic twins reveals the impact of environmental sensitivity on psychiatric and neurodevelopmental phenotypes. Nat Hum Behav (2025)
2025-06-11
21 min
The Journal Club
Ozempic, Mounjaro & the Drop-Off Effect: What the Data Says
Gasoyan H, Butsch WS, Schulte R, Casacchia NJ, Le P, Boyer CB, Griebeler ML, Burguera B, Rothberg MB. Changes in weight and glycemic control following obesity treatment with semaglutide or tirzepatide by discontinuation status. Obesity (Silver Spring). 2025 Jun 10
2025-06-11
18 min
The Journal Club
Popular Sugar Substitute May Impair Brain Blood Vessel Health
Berry AR, Ruzzene ST, Ostrander EI, Wegerson KN, Fersiva NO, Stone MF, Valenti WB, Izaias JE, Holzer JP, Greiner JJ, Garcia VP, DeSouza CA. The Non-Nutritive Sweetner Erythritol Adversely Affects Brain Microvascular Endothelial Cell Function. J Appl Physiol (1985). 2025 Jun 3
2025-06-11
17 min
The Journal Club
Breakthrough for HIV cure using mRNA-based T cell therapeutics
Cevaal, P.M., Kan, S., Fisher, B.M. et al. Efficient mRNA delivery to resting T cells to reverse HIV latency. Nat Commun 16, 4979 (2025)
2025-06-06
18 min
The Journal Club
Iron Deficiency Leads to Mouse Sex Reversal
Okashita, N., Maeda, R., Kuroki, S. et al. Maternal iron deficiency causes male-to-female sex reversal in mouse embryos. Nature (2025).
2025-06-05
14 min
The Journal Club
Is Myelin a Source of Energy During a Marathon?
Ramos-Cabrer, P., Cabrera-Zubizarreta, A., Padro, D. et al. Reversible reduction in brain myelin content upon marathon running. Nat Metab 7, 697–703 (2025)
2025-06-05
13 min
The Journal Club
Excessive Oliec Acid in Olive Oil Drives Fat Cell Growth
Wing A, Jeffery E, Church CD, Goodell J, Saavedra-Peña RDM, Saha M, Holtrup B, Voisin M, Alavi NS, Floody M, Wang Z, Zapadka TE, Garabedian MJ, Varshney R, Rudolph MC, Rodeheffer MS. Dietary oleic acid drives obesogenic adipogenesis via modulation of LXRα signaling. Cell Rep. 2025 Apr 22
2025-06-05
17 min
The Journal Club
Flush Out Alzheimer's Toxins
Chen K, Morizawa YM, Nuriel T, Al-Dalahmah O, Xie Z, Yang G. Selective removal of astrocytic PERK protects against glymphatic impairment and decreases toxic aggregation of β-amyloid and tau. Neuron. 2025 May 19
2025-06-05
16 min
The Journal Club
Why Casinos use blue light
Lander, A.C., Burge, M.T., Thomas, B.G. et al. Circadian photoreception influences loss aversion. Sci Rep 15, 13051 (2025)
2025-06-05
16 min
The Journal Club
Early exposure to dogs could help protect against eczema
Standl M, Budu-Aggrey A, Johnston LJ, Elias MS, Arshad SH, Bager P, Bataille V, Blakeway H, Bønnelykke K, Boomsma D, Brumpton BM, Bustamante Pineda M, Campbell A, Curtin JA, Eliasen A, Fadista JPS, Feenstra B, Gerner T, Medina-Gomez C, Grosche S, Gutzkow KB, Halling AS, Hayward C, Henderson J, Herrera-Luis E, Holloway JW, Hottenga J, O'B Hourihane J, Hu C, Hveem K, Irizar A, Jacquemi B, Jessen L, Kress S, Kurukulaaratchy RJ, Lau S, Llop S, Løset M, Marenholz I, Mason D, McCartney DL, Melbye M, Melén E, Minica C, Murray CS, Nijsten T, Pardo LM, Pas...
2025-06-05
21 min
The Journal Club
Daily mango may support postmenopausal woman's health
Holt RR, Ho E, Li X, Fam VW, Hedayati N, Keen CL, Charoenwoodhipong P, Hackman RM. Short-Term Cardiometabolic Response to Mango Intake in Postmenopausal Women. J Am Nutr Assoc. 2025 Mar 19
2025-06-05
12 min
The Journal Club
Brain Uses Separate Synapses to Balance Learning and Stability
Yang Y, Wong MH, Huang X, Chiu DN, Liu YZ, Prabakaran V, Imran A, Panzeri E, Chen Y, Huguet P, Kunisky A, Ho J, Dong Y, Carter BC, Xu W, Schlüter OM. Distinct transmission sites within a synapse for strengthening and homeostasis. Sci Adv. 2025 Apr 11
2025-06-05
17 min
The Journal Club
Functional polymorphism of CYCLE underlies the diapause variation in moths
Zheng S, Wang Y, Li G, Qin S, Dong Z, Yang X, Xu X, Fang G, Li M, Zhan S. Functional polymorphism of CYCLE underlies the diapause variation in moths. Science. 2025 May 29
2025-06-05
18 min
The Journal Club
The Architecture of Enduring Emotion and Anxiety's Origins
Hanson MA, Gluckman PD. Growing anxious-Are preschoolers matched to their futures? Science. 2025 May 29
2025-06-05
15 min
The Journal Club
Conserved brain-wide emergence of emotional response from sensory experience in humans and mice
Kauvar I, Richman EB, Liu TX, Li C, Vesuna S, Chibukhchyan A, Yamada L, Fogarty A, Solomon E, Choi EY, Mortazavi L, Chau Loo Kung G, Mukunda P, Raja C, Gil-Hernández D, Patron K, Zhang X, Brawer J, Wrobel S, Lusk Z, Lyu D, Mitra A, Hack L, Luo L, Grosenick L, van Roessel P, Williams LM, Heifets BD, Henderson JM, McNab JA, Rodríguez CI, Buch V, Nuyujukian P, Deisseroth K. Conserved brain-wide emergence of emotional response from sensory experience in humans and mice. Science. 2025 May 29
2025-06-05
12 min
The Journal Club
The organ farm
Cohen J. The organ farm. Science. 2025 May 29
2025-06-05
24 min
The Journal Club
Brain-Wide Reinforcement Learning Through Cortical Oscillation
Yoshida T, Sugino H, Yamamoto H, Tanno S, Tamura M, Igarashi J, Isomura Y, Hira R. Synergistic reinforcement learning by cooperation of the cerebellum and basal ganglia. J Neurosci. 2025 Apr 22
2025-06-05
22 min
The Journal Club
Leptin Directs Motor Control Through Dopamine Pathways
Mancini M, Hikima T, Witkovsky P, Patel JC, Stone DW, Affinati AH, Rice ME. Leptin activates dopamine and GABA neurons in the substantia nigra via a local pars compacta-pars reticulata circuit. J Neurosci. 2025 Mar 24
2025-06-05
15 min
The Journal Club
Mef2c Guides Callosal Axon Targeting by Regulating Ephrin Repulsion
Sudarsanam S, Guzman-Clavel LE, Dar N, Ziak J, Shahid N, Jin XO, Kolodkin AL. Mef2c Controls Postnatal Callosal Axon Targeting by Regulating Sensitivity to Ephrin Repulsion. J Neurosci. 2025 May 21
2025-06-04
18 min
The Journal Club
Genetic and environmental factors influencing the relationship between sleep spindles and the volume of the thalamus
Markovic A, Veen D, Hamann C, Adorjan K, Kaess M, Tuura O'Gorman R, Tarokh L. Joint Heritability of Sleep EEG Spindle Activity and Thalamic Volume in Early Adolescence. J Neurosci. 2025 May 21
2025-06-04
16 min
The Journal Club
Night owls are more likely to suffer cognitive decline than morning people
Wenzler AN, Liefbroer AC, Voshaar RCO, Smidt N. Chronotype as a potential risk factor for cognitive decline: The mediating role of sleep quality and health behaviours in a 10-year follow-up study. J Prev Alzheimers Dis. 2025 Apr 11
2025-06-02
11 min
The Journal Club
Early Olfactory Bulb activity may contribute to altered brain maturation and cognitive deficits
Parbst F, Kostka JK, Günther A, Chen YN, Hanganu-Opatz IL, Bitzenhofer SH. Developmental olfactory dysfunction and abnormal odor memory in immune-challenged Disc1+/- mice. J Neurosci. 2025 May 30
2025-05-31
24 min
The Journal Club
Changes in neuronal processing upon falling asleep and awakening
Marmelshtein A, Lavy B, Hadad B, Nir Y. Abrupt and gradual changes in neuronal processing upon falling asleep and awakening. J Neurosci. 2025 May 30
2025-05-31
17 min
The Journal Club
Neural mechanisms underlying the retrieval of temporal order memories
Jiang H, Cai J, Santos-Pata D, Zhu X, Deng Z, Li C, Luo R, Shi L, Cai Y, Wang R, Tong J, Yin J, Zhang S, Kwok SC. Sustained hippocampal theta oscillations reflect experience-dependent learning in backward temporal order memory retrieval. J Neurosci. 2025 May 30
2025-05-31
15 min
The Journal Club
Robustness of working memory to prefrontal cortex microstimulation
Soldado-Magraner J, Minai Y, Yu BM, Smith MA. Robustness of working memory to prefrontal cortex microstimulation. J Neurosci. 2025 May 30
2025-05-31
17 min
The Journal Club
The epigenetic reader PHF23 is required for embryonic neurogenesis
Wen Y, He P, Huang Z, Ding C, Zhang T, Zhang L, Zheng J, Chen M, Chen C, Liu Y, Wang Y, Zhang Y. The epigenetic reader PHF23 is required for embryonic neurogenesis. J Neurosci. 2025 May 30:
2025-05-31
20 min
The Journal Club
Words vs. Pictures: Mapping the Brain’s Reading Tug-of-War
Zeng J, Luo Y, Luo X, Jiao S, Wang K, Cui Z, Zhao C, Dai Z, Liu Y, Jiang Y, Han Z. Neural Distinction Between Visual Word and Object Recognition: An fMRI Study Using Pictographs. J Neurosci. 2025 May 30
2025-05-31
15 min
The Journal Club
Distinct Circuits Link Dorsal/Ventral Hippocampus to MFC
Alemán-Andrade P, Witter MP, Tsutsui KI, Ohara S. Dorsal-Caudal and Ventral Hippocampi Target Different Cell Populations in the Medial Frontal Cortex in Rodents. J Neurosci. 2025 May 28
2025-05-31
13 min
The Journal Club
Neuronal Glutaminolysis Drives Epileptogenesis
Kubista H, Gentile F, Schicker K, Köcher T, Boehm S, Hotka M. Mitochondrial Glutamine Metabolism Drives Epileptogenesis in Primary Hippocampal Neurons. J Neurosci. 2025 May 21
2025-05-26
18 min
The Journal Club
You Could Catch Your Partners Depression Through Kissing
Rastmanesh R, Vellingiri B, Isacco CG, Sadeghinejad A, Daghnall N. Oral Microbiota Transmission Partially Mediates Depression and Anxiety in Newlywed Couples. Explor Res Hypothesis Med. 2025***While the study presents compelling associations, it is observational and does not establish causation.**
2025-05-26
11 min
The Journal Club
Revolutionary Alzheimer's Blood Test
Breakthrough Alzheimer’s Blood Test Explained By NeurologistsBy Mill Etienne, Forbes
2025-05-26
13 min
The Journal Club
Candidate Drug that Boots Protective Brain Protein to Treat Alzheimer's
Cohn, W., Campagna, J., Wi, D. et al. Discovery of a small molecule secreted clusterin enhancer that improves memory in Alzheimer’s disease mice. npj Drug Discov. 2, 7 (2025)
2025-05-26
19 min
The Journal Club
Protective genetic variants against Alzheimer's disease
Marino C, Malotaux V, Giudicessi A, Aguillon D, Sepulveda-Falla D, Lopera F, Quiroz YT. Protective genetic variants against Alzheimer's disease. Lancet Neurol. 2025 Jun;
2025-05-26
19 min
The Journal Club
The gut–brain axis in early Parkinson’s disease: from prodrome to prevention
Oliver PJ, Civitelli L, Hu MT. The gut-brain axis in early Parkinson's disease: from prodrome to prevention. J Neurol. 2025 May 21
2025-05-26
23 min
The Journal Club
Alzheimer's Drug Candidate Protects the Blood-Brain Barrier From Damage
Koh Y, Vázquez-Rosa E, Gao F, Li H, Chakraborty S, Tripathi SJ, Barker S, Bud Z, Bangalore A, Kandjoze UP, León-Alvarado RA, Sridharan PS, Cordova BA, Yu Y, Hyung J, Fang H, Singh S, Katabathula R, LaFramboise T, Kasturi L, Lutterbaugh J, Beard L, Cordova E, Cintrón-Pérez CJ, Franke K, Fragoso MF, Miller E, Indrakumar V, Noel KL, Dhar M, Ajroud K, Zamudio C, Lopes FBTP, Bambakidis E, Zhu X, Wilson B, Flanagan ME, Gefen T, Fujioka H, Fink SP, Desai AB, Dawson D, Williams NS, Kim YK, Ready JM, Paul BD, Shin MK, Markowitz SD...
2025-05-24
17 min
The Journal Club
Light enhances the antibacterial activity of neutrophils through circadian regulation
Du LY, Keerthisinghe P, Rolland L, Sung YJ, Darroch H, Linnerz T, Ashimbayeva E, Grant MJ, Kakadia PM, Ramachandran A, Tups A, Spaink HP, Bohlander SK, Cheeseman J, Crosier PS, Astin JW, Warman G, Hall CJ. A light-regulated circadian timer optimizes neutrophil bactericidal activity to boost daytime immunity. Sci Immunol. 2025 May 23
2025-05-24
15 min
The Journal Club
Vitamin D Supplements Show Signs of Protection Against Aging
Haidong Zhu, JoAnn E. Manson, Nancy R. Cook, Bayu B. Bekele, Li Chen, Kevin J. Kane, Ying Huang, Wenjun Li, William Christen, I-Min Lee, Yanbin Dong,Vitamin D3 and Marine Omega-3 Fatty Acids Supplementation and Leukocyte Telomere Length: 4-Year Findings from the VITAL Randomized Controlled Trial,The American Journal of Clinical Nutrition,2025
2025-05-24
13 min
The Journal Club
Biological Markers for Teen Depression
Alice Morgunova, Nicholas O’Toole, Fatme Abboud, Saché Coury, Gary Gang Chen, Maxime Teixeira, Eamon Fitzgerald, Gustavo Turecki, Anthony J. Gifuni, Ian H. Gotlib, Corina Nagy, Michael J. Meaney, Tiffany C. Ho, Cecilia Flores,Peripheral microRNA signatures in adolescent depression,Biological Psychiatry Global Open Science,2025,
2025-05-24
14 min
The Journal Club
Muscle Quality as a Marker for Early Cognitive Decline in Adults
Ikeue K, Kato H, Tanaka M, Yamakage H, Kato S, Iwasa M, Oishi K, Yamamoto Y, Kanasaki M, Masuda I, Ishii K, Satoh-Asahara N. Phase Angle Is a Potential Novel Early Marker for Sarcopenia and Cognitive Impairment in the General Population. J Cachexia Sarcopenia Muscle. 2025 Jun
2025-05-24
11 min
The Journal Club
Math and biology meet in the cerebellum
Mohammad Amin Fakharian et al., A vector calculus for neural computation in the cerebellum. Science 388, 869-875 (2025)
2025-05-22
14 min
The Journal Club
The emergence and demise of giant sloths
Alberto Boscaini et al. ,The emergence and demise of giant sloths.Science 388,864-868(2025)
2025-05-22
19 min
The Journal Club
Turf algae redefine the chemical landscape of temperate reefs, limiting kelp forest recovery
Shane P. Farrell et al. ,Turf algae redefine the chemical landscape of temperate reefs, limiting kelp forest recovery.Science388,876-880(2025)
2025-05-22
13 min
The Journal Club
Health impacts of exposure to synthetic chemicals in food
Muncke, J., Touvier, M., Trasande, L. et al. Health impacts of exposure to synthetic chemicals in food. Nat Med 31, 1431–1443 (2025)
2025-05-22
22 min
The Journal Club
Eleanor Maguire (1970–2025)
Price, C.J., Zeidman, P. & Callaghan, M.F. Eleanor Maguire (1970–2025). Nat Neurosci (2025).
2025-05-22
09 min
The Journal Club
A dynamic and multimodal framework to define microglial states
Sankowski, R., Prinz, M. A dynamic and multimodal framework to define microglial states. Nat Neurosci (2025)
2025-05-22
18 min
The Journal Club
Widespread brain–body integration during changes of arousal
Widespread brain–body integration during changes of arousal. Nat Neurosci (2025).
2025-05-22
13 min
The Journal Club
A basic role for glia in sleep homeostasis
Kirszenblat, L., van Swinderen, B. A basic role for glia in sleep homeostasis. Nat Neurosci (2025)
2025-05-22
13 min
The Journal Club
Microglia and T Cells Drive White Matter Aging
Monteiro, J.K., Miron, V.E. Microglia conduct the symphony of white matter degeneration in aging through T cell recruitment. Nat Neurosci (2025)
2025-05-22
14 min
The Journal Club
Neuronal Senescence in Dorsal Root Ganglia and Pain
Donovan, L.J., Brewer, C.L., Bond, S.F. et al. Aging and injury drive neuronal senescence in the dorsal root ganglia. Nat Neurosci 28, 985–997 (2025)
2025-05-22
19 min
The Journal Club
mGluR5 Mediates Activity-Driven Myelin Sheath Growth
Braaker, P.N., Mi, X., Soong, D. et al. Activity-driven myelin sheath growth is mediated by mGluR5. Nat Neurosci (2025)
2025-05-22
19 min
The Journal Club
Cysteine Deficiency Drives Weight Loss by Depleting coenzyme A
Varghese, A., Gusarov, I., Gamallo-Lana, B. et al. Unravelling cysteine-deficiency-associated rapid weight loss. Nature (2025)
2025-05-22
20 min
The Journal Club
Insulin Resistance may be a factor linking Alzheimer's and epilepsy
Alves SS, Servilha-Menezes G, Rossi L, de Oliveira JAC, Grigorio-de-Sant'Ana M, Sebollela A, da Silva-Junior RMP, Garcia-Cairasco N. Insulin signaling disruption exacerbates memory impairment and seizure susceptibility in an epilepsy model with Alzheimer's disease-like pathology. J Neural Transm (Vienna). 2025 Feb 22
2025-05-22
11 min
The Journal Club
Genomic Study of Long COVID Finds FOXP4 Link
Genomic Study of Long COVID Finds FOXP4 Link
2025-05-22
13 min
The Journal Club
Astrocytic PERK Inhibition Restores Glymphatic Function in AD
Kai Chen, Yosuke M. Morizawa, Tal Nuriel, Osama Al-Dalahmah, Zhongcong Xie, Guang Yang,Selective removal of astrocytic PERK protects against glymphatic impairment and decreases toxic aggregation of β-amyloid and tau,Neuron, 2025
2025-05-22
13 min
The Journal Club
How poverty and loneliness are linked to pain, fatigue, and low mood
Davis AJ, Cohen E, Nettle D. Associations amongst poverty, loneliness, and a defensive symptom cluster characterised by pain, fatigue, and low mood. Public Health. 2025 May
2025-05-22
11 min
The Journal Club
Predicting Postpartum Depression Risk Before Discharge
Clapp MA, Castro VM, Verhaak P, McCoy TH, Shook LL, Edlow AG, Perlis RH. Stratifying Risk for Postpartum Depression at Time of Hospital Discharge. Am J Psychiatry. 2025 May 19
2025-05-21
16 min
The Journal Club
Nucleus Accumbens Dopamine Predicts Future Defensive Actions
Fisher AA, Gonzalez LS, Cappel ZR, Grover KE, Waclaw RR, Robinson JE. Dopaminergic encoding of future defensive actions in the mouse nucleus accumbens. PNAS Nexus. 2025 Apr 29
2025-05-21
11 min
The Journal Club
Don't hit the snooze button when waking up
Robbins, R., Sääf, D., Weaver, M.D. et al. Snooze alarm use in a global population of smartphone users. Sci Rep 15
2025-05-21
13 min
The Journal Club
Inflammation tied to motivation deficits in schizophrenia
Goldsmith, D.R., Ning, C.S., Strauss, G.P. et al. Inflammation is associated with avolition and reduced resting state functional connectivity in corticostriatal reward circuitry in patients with schizophrenia. Neuropsychopharmacol. (2025)
2025-05-21
12 min
The Journal Club
Quantifying the lifespan of synaptic proteins during learning using Delta
Mohar, B., Michel, G., Wang, YZ. et al. DELTA: a method for brain-wide measurement of synaptic protein turnover reveals localized plasticity during learning. Nat Neurosci 28
2025-05-21
14 min
The Journal Club
Hippocampal Replay Composes Future Behavior
Bakermans, J.J.W., Warren, J., Whittington, J.C.R. et al. Constructing future behavior in the hippocampal formation through composition and replay. Nat Neurosci 28
2025-05-21
37 min
The Journal Club
Linking brain inflammation to repetitive behaviors in Autism and OCD
Jung H, Kim B, Jang G, Kim H, Lee AR, Yoon SH, Lee KS, Hyun G, Kim Y, Ko J, Yu JW, Um JW. The NLRP3 inflammasome in microglia regulates repetitive behavior by modulating NMDA glutamate receptor functions. Cell Rep. 2025 May 6
2025-05-21
11 min
The Journal Club
Cancer Needs Neuroscience and Neuroscientists
Monje M, Winkler F. Cancer research needs neuroscience and neuroscientists. Nat Neurosci. 2025 May;28
2025-05-18
21 min
The Journal Club
Why Women have faster heart rates than Men
Li N, Webb A, Kennelly J, Sharma R, Whitson BA, Mohler PJ, Hummel JD, Zhao J, Fedorov V. Heart Rate Mystery Unveiled: Sex Differences in Human Sinoatrial Node Genes and Female Tachycardia. Circ Arrhythm Electrophysiol. 2025 Apr 23
2025-05-17
16 min
The Journal Club
First-of-Its-Kind mRNA Therapy Corrects Rare Metabolic Mutation in Infant
Musunuru K, Grandinette SA, Wang X, Hudson TR, Briseno K, Berry AM, Hacker JL, Hsu A, Silverstein RA, Hille LT, Ogul AN, Robinson-Garvin NA, Small JC, McCague S, Burke SM, Wright CM, Bick S, Indurthi V, Sharma S, Jepperson M, Vakulskas CA, Collingwood M, Keogh K, Jacobi A, Sturgeon M, Brommel C, Schmaljohn E, Kurgan G, Osborne T, Zhang H, Kinney K, Rettig G, Barbosa CJ, Semple SC, Tam YK, Lutz C, George LA, Kleinstiver BP, Liu DR, Ng K, Kassim SH, Giannikopoulos P, Alameh MG, Urnov FD, Ahrens-Nicklas RC. Patient-Specific In Vivo Gene Editing to Treat a Rare...
2025-05-17
15 min
The Journal Club
Caffeine consumption might protect against cognitive decline and of Alzheimer’s disease
Ashfaq Z, Younas Z, Nathaniel E, Rehman A, Siddiqi A, Rasool N, Amir M. Association Between Caffeine Intake and Alzheimer's Disease Progression: A Systematic Review. Cureus. 2025 Mar 20
2025-05-17
15 min
The Journal Club
COVID Brain Fog May Have a Biological Trigger, Study Finds
Lawrence MR, Arnetz JE, Counts SE, Ahmed A, Arnetz BB. Self-reported health, neuropsychological tests and biomarkers in fully recovered COVID-19 patients vs patients with post-COVID cognitive symptoms: A pilot study. PLoS One. 2025 May 15
2025-05-17
14 min
The Journal Club
SYNGAP1 Roles in Excitability and Seizure Susceptibility
Brill J, Clarke B, Hong I, Huganir RL. Dissociation of SYNGAP1 enzymatic and structural roles: Intrinsic excitability and seizure susceptibility. Proc Natl Acad Sci U S A. 2025 May 6
2025-05-17
12 min
George Brauchler DA Podcast #1: Meet DA George Brauchler
Podcast #6 Meet Chief Deputy DA Danielle Jaramillo
Welcome to the George Brauchler DA Podcast—your front-row seat to the world of true crime, seen through the eyes of one of Colorado's most seasoned prosecutors. In today's episode, we meet Chief Deputy District Attorney Danielle Jaramillo—a sex crimes prosecutor who has faced down some of the most heinous offenders in the state. From a tough upbringing in Utah to becoming a standout soccer player at the U.S. Air Force Academy, Danielle's journey took a sharp turn when career-ending injuries led her away from athletics and into the world of law. Danielle shar...
2025-05-02
38 min
George Brauchler DA Podcast #1: Meet DA George Brauchler
George Brauchler DA Podcast #6: Meet Chief Deputy DA Danielle Jaramillo
Welcome to the George Brauchler DA Podcast- your front row seat to the world of true crime through the lens of one of Colorado's most experienced prosecutors. In today's episide we'll meet Chief Deputy District Attorney, Danielle Jaramillo- a sex crimes prosecutor who has faced down some of the most heinous criminals in the state. From a tough upbringing in Utah, to her journey to the U.S. Air Force Academy as a standout soccer player, Danielle's path took a sharp turn after career ending injries led her away from athletics and into the world of law. ...
2025-05-02
38 min
George Brauchler DA Podcast #1: Meet DA George Brauchler
George Brauchler DA Podcast #6: Meet Chief Deputy DA Danielle Jaramillo
Welcome to the George Brauchler DA Podcast- your front row seat to the world of true crime through the lens of one of Colorado's most experienced prosecutors. In today's episide we'll meet Chief Deputy District Attorney, Danielle Jaramillo- a sex crimes prosecutor who has faced down some of the most heinous criminals in the state. From a tough upbringing in Utah, to her journey to the U.S. Air Force Academy as a standout soccer player, Danielle's path took a sharp turn after career ending injries led her away from athletics and into the world of law. ...
2025-05-02
38 min
George Brauchler DA Podcast #1: Meet DA George Brauchler
George Brauchler DA Podcast #6: Meet Chief Deputy DA Danielle Jaramillo
Welcome to the George Brauchler DA Podcast- your front row seat to the world of true crime through the lens of one of Colorado's most experienced prosecutors. In today's episide we'll meet Chief Deputy District Attorney, Danielle Jaramillo- a sex crimes prosecutor who has faced down some of the most heinous criminals in the state. From a tough upbringing in Utah, to her journey to the U.S. Air Force Academy as a standout soccer player, Danielle's path took a sharp turn after career ending injuries led her away from athletics and into the world of law. ...
2025-05-02
38 min
Life List: A Birding Podcast
Tribute to Tom Johnson, a remarkable bird expert and human
In our season finale, we pay tribute to Tom Johnson, a distinguished bird expert and an exceptional human being, who passed away unexpectedly in 2023. Tom was a guiding light in the birding community, known for his profound knowledge, infectious enthusiasm, and unwavering dedication to bird conservation and science. This episode features an interview with Tom, recorded shortly before his passing.Listen to the American Birding Association's podcast tribute to Tom here. Learn more about Tom's impact on the birding community here and here in these two remembrance articles. Imagine yourself birding with To...
2024-06-03
1h 21
The Book Leads: Impactful Books For Life & Leadership
Episode 79: Tom Hine, CFP®, CFS®, MBA & His Book, The Balanced Wealth Approach: Secrets To Living Long And Living Rich
Episode 79: Tom Hine, CFP®, CFS®, MBA & His Book, The Balanced Wealth Approach: Secrets To Living Long And Living Rich In this episode, Tom, a CERTIFIED FINANCIAL PLANNER™, author, and founder and CEO of Capital Wealth Management, shares with me how there should be comparable focus on both wealth and health when it comes to our futures -- even in his field of wealth management. Through his own journey in finance (the numbers) and karate, meditation, yoga (the physical and the mind), he demonstrates that he's living what he's preaching. The message he shares with...
2023-12-04
1h 32
Warrior's Edge Podcast
Mike Jaramillo Interview
Mike Jaramillo is a 5th degree black belt in Brazilian Jiu-Jitsu under Renzo Gracie and John Danaher. He also teaches advanced classes at Renzo Gracie Academy. We deep dive into BJJ training concepts, thought provoking training mindset, insight on his and John Danaher's approach to teaching, how he got into BJJ, Renzo's first school in the US and the early years, and much more!
2023-07-24
54 min
Let's Speak Frankly - 3 minute English Listening and Learning
Rich guy Tom
Send us a textWhile listening Try to answer these 2 questions;Why did Tom lose his business?What did Tom do with his free time?Vocabulary;Fancy (adjective) - over the top in structure or decoration.Lavish (adjective) - rich, elaborate, or luxuriousShow off (phrasal verb) - display someone or something that is a source of pride.Bankrupt (adjective) - (of a person or organization) declared in law as unable to pay their
2023-04-02
02 min