Shows
The Journal ClubHuman CLOCK's Role in Cognitive FlexibilityLiu, Y., Fontenot, M.R., Kulkarni, A. et al. Human CLOCK enhances neocortical function. Nat Neurosci (2025)
2025-06-3012 min
The Journal ClubUnlocked a New Method of Treating Alzheimer's Disease and other Cognitive DeclineNeuronal glycogen breakdown mitigates tauopathy via pentose-phosphate-pathway-mediated oxidative stress reduction
2025-06-3014 min
The Journal ClubThe Neural Circuit Governing Sleep HomeostasisLee SS, Liu Q, Cheng AHR, Kim DW, Boudreau DM, Mehta A, Keles MF, Fejfer R, Palmer I, Park KH, Münzberg H, Harris TD, Graves AR, Blackshaw S, Wu MN. Sleep need-dependent plasticity of a thalamic circuit promotes homeostatic recovery sleep. Science. 2025 Jun 19
2025-06-2311 min
The Journal ClubOlfactory Bulb and Memory Dysfunction in Neuropsychiatric DisordersParbst F, Kostka JK, Günther A, Chen YN, Hanganu-Opatz IL, Bitzenhofer SH. Developmental Olfactory Dysfunction and Abnormal Odor Memory in Immune-Challenged Disc1+/- Mice. J Neurosci. 2025 Jun 18
2025-06-2313 min
The Journal ClubSCN GRPNs: Modulatory Role in Circadian Photic EntrainmentLi R, Inoue R, Mori H, Hirano A, Sakurai T. Functional Roles of Gastrin-Releasing Peptide-Producing Neurons in the Suprachiasmatic Nucleus: Insights into Photic Entrainment and Circadian Regulation. J Neurosci. 2025 Jun 18
2025-06-2316 min
The Journal ClubHippocampal Ripples Decrease During Physical Actions in RodentsSakairi T, Kawabata M, Rios A, Sakai Y, Isomura Y. Hippocampal Sharp-Wave Ripples Decrease during Physical Actions Including Consummatory Behavior in Immobile Rodents. J Neurosci. 2025 Jun 18
2025-06-2315 min
The Journal ClubDDX3X Mutations: Sex-Specific Effects on Brain DevelopmentMossa, A., Dierdorff, L., Lukin, J. et al. Sex-specific perturbations of neuronal development caused by mutations in the autism risk gene DDX3X. Nat Commun 16, 4512 (2025)
2025-06-2118 min
The Journal ClubAutism and Social Avoidance: Neural Circuitry of Touch DiscriminationChari, T., Hernandez, A., Couto, J. et al. A reduced ability to discriminate social from non-social touch at the circuit level may underlie social avoidance in autism. Nat Commun 16, 4600 (2025). https://doi.org/10.1038/s41467-025-59852-6
2025-06-2012 min
The Journal ClubAutism associated Chd8 Gene Duplication and Neurodevelopmental Defects in MiceKawamura, A., Fujii, K., Tamada, K. et al. Duplication of the autism-related gene Chd8 leads to behavioral hyperactivity and neurodevelopmental defects in mice. Nat Commun 16, 4641 (2025). https://doi.org/10.1038/s41467-025-59853-5
2025-06-2012 min
The Journal ClubPrecision nutrition for Cardiometabolic DiseasesGuasch-Ferré, M., Wittenbecher, C., Palmnäs, M. et al. Precision nutrition for cardiometabolic diseases. Nat Med 31, 1444–1453 (2025)
2025-06-1717 min
The Journal ClubHealth impacts of exposure to synthetic chemicals in foodMuncke, J., Touvier, M., Trasande, L. et al. Health impacts of exposure to synthetic chemicals in food. Nat Med 31, 1431–1443 (2025)
2025-06-1726 min
The Journal ClubHow you breathe is like a fingerprint that can identify youSoroka T, Ravia A, Snitz K, Honigstein D, Weissbrod A, Gorodisky L, Weiss T, Perl O, Sobel N. Humans have nasal respiratory fingerprints. Curr Biol. 2025 May 30
2025-06-1713 min
The Journal ClubMicrobiome Signatures of Parkinson’s Disease Revealed Through AIRomano, S., Wirbel, J., Ansorge, R. et al. Machine learning-based meta-analysis reveals gut microbiome alterations associated with Parkinson’s disease. Nat Commun 16, 4227 (2025)
2025-06-1721 min
The Journal ClubClimate Change Linked to Sleep ApneaLechat, B., Manners, J., Pinilla, L. et al. Global warming may increase the burden of obstructive sleep apnea. Nat Commun 16, 5100 (2025)
2025-06-1718 min
The Journal ClubNeural Flexibility: A Possible Autism InterventionWatanabe, T., Yamasue, H. Noninvasive reduction of neural rigidity alters autistic behaviors in humans. Nat Neurosci 28, 1348–1360 (2025)
2025-06-1223 min
The Journal ClubHow Exercise Rewires the Brainda Rocha, J.F., Lance, M.L., Luo, R. et al. Protective exercise responses in the dentate gyrus of Alzheimer’s disease mouse model revealed with single-nucleus RNA-sequencing. Nat Neurosci (2025).
2025-06-1217 min
The Journal ClubWhy don’t bats get cancer?Athar, F., Zheng, Z., Riquier, S. et al. Limited cell-autonomous anticancer mechanisms in long-lived bats. Nat Commun 16, 4125 (2025)
2025-06-1212 min
The Journal ClubPsilocybin Remodels Cortical Neurons and BehaviorShao, LX., Liao, C., Davoudian, P.A. et al. Psilocybin’s lasting action requires pyramidal cell types and 5-HT2A receptors. Nature 642, 411–420 (2025)
2025-06-1216 min
The Journal ClubWhy a Boy Could Not Feel PainCRISPR helps to show why a boy felt no pain. Nature. 2025 Jun;Antunes FTT, Gandini MA, Garcia-Caballero A, Huang S, Ali MY, Gambeta E, Souza IA, Harding EK, Ferron L, Stray-Pedersen A, Gadotti VM, Zamponi GW. A pathological missense mutation in the deubiquitinase USP5 leads to insensitivity to pain. J Exp Med. 2025 Aug 4
2025-06-1211 min
The Journal ClubHow to keep weight off after obesity drugsNature 11 June 2025 How to keep weight off after obesity drugs by Elie DolginRodriguez, P. J. et al. JAMA Netw. Open 8, e2457349 (2025).Eisenberg, D. et al. Surg. Obes. Relat. Dis. 18, 1345–1356 (2022)Itani, M. I. et al. Obes. Surg. 32, 381–390 (2022).Maselli, D. B. et al. Gastroenterology 167, 1457–1459 (2024).van Baar, A. C. G. et al. Diabetes Res. Clin. Pract. 184, 109194 (2022).Mingrone, G. et al. Gut 71, 254–264 (2022).Aronne, L. J. et al. JAMA 331, 38–48 (2024).Lundgren, J. R. et al. N. Engl. J. Med. 384, 1719–1730 (2021).Paddu, N. U., Lawrence, B., Wong, S., Poon, S. J. & Srivasta...
2025-06-1213 min
The Journal ClubWorld first: brain implant lets man speak with expression ― and singNature 11 June 2025 World first: brain implant lets man speak with expression ― and sing by Miryam NaddafSinger-Clark T, Hou X, Card NS, Wairagkar M, Iacobacci C, Peracha H, Hochberg LR, Stavisky SD, Brandman DM. Speech motor cortex enables BCI cursor control and click. J Neural Eng. 2025 May 14
2025-06-1208 min
The Journal ClubEmergence and Development of a Gender Gap in MathematicsMartinot, P., Colnet, B., Breda, T. et al. Rapid emergence of a maths gender gap in first grade. Nature (2025)
2025-06-1222 min
The Journal ClubChanges in the auditory cortex of children receiving gene therapy for deafness.Changes in the auditory cortex of children receiving gene therapy for deafness. Nat Hum Behav (2025).
2025-06-1115 min
The Journal ClubHow Single Neurons in the Amygdala and Hippocampus encode face identityCao, R., Wang, J., Lin, C. et al. Feature-based encoding of face identity by single neurons in the human amygdala and hippocampus. Nat Hum Behav (2025)
2025-06-1116 min
The Journal ClubIdentical Twins, Unequal Outcomes: The Genetics of SensitivityAssary, E., Coleman, J.R.I., Hemani, G. et al. Genetics of monozygotic twins reveals the impact of environmental sensitivity on psychiatric and neurodevelopmental phenotypes. Nat Hum Behav (2025)
2025-06-1121 min
The Journal ClubOzempic, Mounjaro & the Drop-Off Effect: What the Data SaysGasoyan H, Butsch WS, Schulte R, Casacchia NJ, Le P, Boyer CB, Griebeler ML, Burguera B, Rothberg MB. Changes in weight and glycemic control following obesity treatment with semaglutide or tirzepatide by discontinuation status. Obesity (Silver Spring). 2025 Jun 10
2025-06-1118 min
The Journal ClubPopular Sugar Substitute May Impair Brain Blood Vessel HealthBerry AR, Ruzzene ST, Ostrander EI, Wegerson KN, Fersiva NO, Stone MF, Valenti WB, Izaias JE, Holzer JP, Greiner JJ, Garcia VP, DeSouza CA. The Non-Nutritive Sweetner Erythritol Adversely Affects Brain Microvascular Endothelial Cell Function. J Appl Physiol (1985). 2025 Jun 3
2025-06-1117 min
The Journal ClubBreakthrough for HIV cure using mRNA-based T cell therapeuticsCevaal, P.M., Kan, S., Fisher, B.M. et al. Efficient mRNA delivery to resting T cells to reverse HIV latency. Nat Commun 16, 4979 (2025)
2025-06-0618 min
The Journal ClubIron Deficiency Leads to Mouse Sex ReversalOkashita, N., Maeda, R., Kuroki, S. et al. Maternal iron deficiency causes male-to-female sex reversal in mouse embryos. Nature (2025).
2025-06-0514 min
The Journal ClubIs Myelin a Source of Energy During a Marathon?Ramos-Cabrer, P., Cabrera-Zubizarreta, A., Padro, D. et al. Reversible reduction in brain myelin content upon marathon running. Nat Metab 7, 697–703 (2025)
2025-06-0513 min
The Journal ClubExcessive Oliec Acid in Olive Oil Drives Fat Cell GrowthWing A, Jeffery E, Church CD, Goodell J, Saavedra-Peña RDM, Saha M, Holtrup B, Voisin M, Alavi NS, Floody M, Wang Z, Zapadka TE, Garabedian MJ, Varshney R, Rudolph MC, Rodeheffer MS. Dietary oleic acid drives obesogenic adipogenesis via modulation of LXRα signaling. Cell Rep. 2025 Apr 22
2025-06-0517 min
The Journal ClubFlush Out Alzheimer's ToxinsChen K, Morizawa YM, Nuriel T, Al-Dalahmah O, Xie Z, Yang G. Selective removal of astrocytic PERK protects against glymphatic impairment and decreases toxic aggregation of β-amyloid and tau. Neuron. 2025 May 19
2025-06-0516 min
The Journal ClubWhy Casinos use blue lightLander, A.C., Burge, M.T., Thomas, B.G. et al. Circadian photoreception influences loss aversion. Sci Rep 15, 13051 (2025)
2025-06-0516 min
The Journal ClubEarly exposure to dogs could help protect against eczemaStandl M, Budu-Aggrey A, Johnston LJ, Elias MS, Arshad SH, Bager P, Bataille V, Blakeway H, Bønnelykke K, Boomsma D, Brumpton BM, Bustamante Pineda M, Campbell A, Curtin JA, Eliasen A, Fadista JPS, Feenstra B, Gerner T, Medina-Gomez C, Grosche S, Gutzkow KB, Halling AS, Hayward C, Henderson J, Herrera-Luis E, Holloway JW, Hottenga J, O'B Hourihane J, Hu C, Hveem K, Irizar A, Jacquemi B, Jessen L, Kress S, Kurukulaaratchy RJ, Lau S, Llop S, Løset M, Marenholz I, Mason D, McCartney DL, Melbye M, Melén E, Minica C, Murray CS, Nijsten T, Pardo LM, Pas...
2025-06-0521 min
The Journal ClubDaily mango may support postmenopausal woman's healthHolt RR, Ho E, Li X, Fam VW, Hedayati N, Keen CL, Charoenwoodhipong P, Hackman RM. Short-Term Cardiometabolic Response to Mango Intake in Postmenopausal Women. J Am Nutr Assoc. 2025 Mar 19
2025-06-0512 min
The Journal ClubBrain Uses Separate Synapses to Balance Learning and StabilityYang Y, Wong MH, Huang X, Chiu DN, Liu YZ, Prabakaran V, Imran A, Panzeri E, Chen Y, Huguet P, Kunisky A, Ho J, Dong Y, Carter BC, Xu W, Schlüter OM. Distinct transmission sites within a synapse for strengthening and homeostasis. Sci Adv. 2025 Apr 11
2025-06-0517 min
The Journal ClubFunctional polymorphism of CYCLE underlies the diapause variation in mothsZheng S, Wang Y, Li G, Qin S, Dong Z, Yang X, Xu X, Fang G, Li M, Zhan S. Functional polymorphism of CYCLE underlies the diapause variation in moths. Science. 2025 May 29
2025-06-0518 min
The Journal ClubThe Architecture of Enduring Emotion and Anxiety's OriginsHanson MA, Gluckman PD. Growing anxious-Are preschoolers matched to their futures? Science. 2025 May 29
2025-06-0515 min
The Journal ClubConserved brain-wide emergence of emotional response from sensory experience in humans and miceKauvar I, Richman EB, Liu TX, Li C, Vesuna S, Chibukhchyan A, Yamada L, Fogarty A, Solomon E, Choi EY, Mortazavi L, Chau Loo Kung G, Mukunda P, Raja C, Gil-Hernández D, Patron K, Zhang X, Brawer J, Wrobel S, Lusk Z, Lyu D, Mitra A, Hack L, Luo L, Grosenick L, van Roessel P, Williams LM, Heifets BD, Henderson JM, McNab JA, Rodríguez CI, Buch V, Nuyujukian P, Deisseroth K. Conserved brain-wide emergence of emotional response from sensory experience in humans and mice. Science. 2025 May 29
2025-06-0512 min
2025-06-0524 min
The Journal ClubBrain-Wide Reinforcement Learning Through Cortical OscillationYoshida T, Sugino H, Yamamoto H, Tanno S, Tamura M, Igarashi J, Isomura Y, Hira R. Synergistic reinforcement learning by cooperation of the cerebellum and basal ganglia. J Neurosci. 2025 Apr 22
2025-06-0522 min
The Journal ClubLeptin Directs Motor Control Through Dopamine PathwaysMancini M, Hikima T, Witkovsky P, Patel JC, Stone DW, Affinati AH, Rice ME. Leptin activates dopamine and GABA neurons in the substantia nigra via a local pars compacta-pars reticulata circuit. J Neurosci. 2025 Mar 24
2025-06-0515 min
The Journal ClubMef2c Guides Callosal Axon Targeting by Regulating Ephrin RepulsionSudarsanam S, Guzman-Clavel LE, Dar N, Ziak J, Shahid N, Jin XO, Kolodkin AL. Mef2c Controls Postnatal Callosal Axon Targeting by Regulating Sensitivity to Ephrin Repulsion. J Neurosci. 2025 May 21
2025-06-0418 min
The Journal ClubGenetic and environmental factors influencing the relationship between sleep spindles and the volume of the thalamusMarkovic A, Veen D, Hamann C, Adorjan K, Kaess M, Tuura O'Gorman R, Tarokh L. Joint Heritability of Sleep EEG Spindle Activity and Thalamic Volume in Early Adolescence. J Neurosci. 2025 May 21
2025-06-0416 min
The Journal ClubNight owls are more likely to suffer cognitive decline than morning peopleWenzler AN, Liefbroer AC, Voshaar RCO, Smidt N. Chronotype as a potential risk factor for cognitive decline: The mediating role of sleep quality and health behaviours in a 10-year follow-up study. J Prev Alzheimers Dis. 2025 Apr 11
2025-06-0211 min
The Journal ClubEarly Olfactory Bulb activity may contribute to altered brain maturation and cognitive deficitsParbst F, Kostka JK, Günther A, Chen YN, Hanganu-Opatz IL, Bitzenhofer SH. Developmental olfactory dysfunction and abnormal odor memory in immune-challenged Disc1+/- mice. J Neurosci. 2025 May 30
2025-05-3124 min
The Journal ClubChanges in neuronal processing upon falling asleep and awakeningMarmelshtein A, Lavy B, Hadad B, Nir Y. Abrupt and gradual changes in neuronal processing upon falling asleep and awakening. J Neurosci. 2025 May 30
2025-05-3117 min
The Journal ClubNeural mechanisms underlying the retrieval of temporal order memoriesJiang H, Cai J, Santos-Pata D, Zhu X, Deng Z, Li C, Luo R, Shi L, Cai Y, Wang R, Tong J, Yin J, Zhang S, Kwok SC. Sustained hippocampal theta oscillations reflect experience-dependent learning in backward temporal order memory retrieval. J Neurosci. 2025 May 30
2025-05-3115 min
The Journal ClubRobustness of working memory to prefrontal cortex microstimulationSoldado-Magraner J, Minai Y, Yu BM, Smith MA. Robustness of working memory to prefrontal cortex microstimulation. J Neurosci. 2025 May 30
2025-05-3117 min
The Journal ClubThe epigenetic reader PHF23 is required for embryonic neurogenesisWen Y, He P, Huang Z, Ding C, Zhang T, Zhang L, Zheng J, Chen M, Chen C, Liu Y, Wang Y, Zhang Y. The epigenetic reader PHF23 is required for embryonic neurogenesis. J Neurosci. 2025 May 30:
2025-05-3120 min
The Journal ClubWords vs. Pictures: Mapping the Brain’s Reading Tug-of-WarZeng J, Luo Y, Luo X, Jiao S, Wang K, Cui Z, Zhao C, Dai Z, Liu Y, Jiang Y, Han Z. Neural Distinction Between Visual Word and Object Recognition: An fMRI Study Using Pictographs. J Neurosci. 2025 May 30
2025-05-3115 min
The Journal ClubDistinct Circuits Link Dorsal/Ventral Hippocampus to MFCAlemán-Andrade P, Witter MP, Tsutsui KI, Ohara S. Dorsal-Caudal and Ventral Hippocampi Target Different Cell Populations in the Medial Frontal Cortex in Rodents. J Neurosci. 2025 May 28
2025-05-3113 min
The Journal ClubNeuronal Glutaminolysis Drives EpileptogenesisKubista H, Gentile F, Schicker K, Köcher T, Boehm S, Hotka M. Mitochondrial Glutamine Metabolism Drives Epileptogenesis in Primary Hippocampal Neurons. J Neurosci. 2025 May 21
2025-05-2618 min
The Journal ClubYou Could Catch Your Partners Depression Through KissingRastmanesh R, Vellingiri B, Isacco CG, Sadeghinejad A, Daghnall N. Oral Microbiota Transmission Partially Mediates Depression and Anxiety in Newlywed Couples. Explor Res Hypothesis Med. 2025***While the study presents compelling associations, it is observational and does not establish causation.**
2025-05-2611 min
The Journal ClubRevolutionary Alzheimer's Blood TestBreakthrough Alzheimer’s Blood Test Explained By NeurologistsBy Mill Etienne, Forbes
2025-05-2613 min
The Journal ClubCandidate Drug that Boots Protective Brain Protein to Treat Alzheimer'sCohn, W., Campagna, J., Wi, D. et al. Discovery of a small molecule secreted clusterin enhancer that improves memory in Alzheimer’s disease mice. npj Drug Discov. 2, 7 (2025)
2025-05-2619 min
The Journal ClubProtective genetic variants against Alzheimer's diseaseMarino C, Malotaux V, Giudicessi A, Aguillon D, Sepulveda-Falla D, Lopera F, Quiroz YT. Protective genetic variants against Alzheimer's disease. Lancet Neurol. 2025 Jun;
2025-05-2619 min
The Journal ClubThe gut–brain axis in early Parkinson’s disease: from prodrome to preventionOliver PJ, Civitelli L, Hu MT. The gut-brain axis in early Parkinson's disease: from prodrome to prevention. J Neurol. 2025 May 21
2025-05-2623 min
The Journal ClubAlzheimer's Drug Candidate Protects the Blood-Brain Barrier From DamageKoh Y, Vázquez-Rosa E, Gao F, Li H, Chakraborty S, Tripathi SJ, Barker S, Bud Z, Bangalore A, Kandjoze UP, León-Alvarado RA, Sridharan PS, Cordova BA, Yu Y, Hyung J, Fang H, Singh S, Katabathula R, LaFramboise T, Kasturi L, Lutterbaugh J, Beard L, Cordova E, Cintrón-Pérez CJ, Franke K, Fragoso MF, Miller E, Indrakumar V, Noel KL, Dhar M, Ajroud K, Zamudio C, Lopes FBTP, Bambakidis E, Zhu X, Wilson B, Flanagan ME, Gefen T, Fujioka H, Fink SP, Desai AB, Dawson D, Williams NS, Kim YK, Ready JM, Paul BD, Shin MK, Markowitz SD...
2025-05-2417 min
The Journal ClubLight enhances the antibacterial activity of neutrophils through circadian regulationDu LY, Keerthisinghe P, Rolland L, Sung YJ, Darroch H, Linnerz T, Ashimbayeva E, Grant MJ, Kakadia PM, Ramachandran A, Tups A, Spaink HP, Bohlander SK, Cheeseman J, Crosier PS, Astin JW, Warman G, Hall CJ. A light-regulated circadian timer optimizes neutrophil bactericidal activity to boost daytime immunity. Sci Immunol. 2025 May 23
2025-05-2415 min
The Journal ClubVitamin D Supplements Show Signs of Protection Against AgingHaidong Zhu, JoAnn E. Manson, Nancy R. Cook, Bayu B. Bekele, Li Chen, Kevin J. Kane, Ying Huang, Wenjun Li, William Christen, I-Min Lee, Yanbin Dong,Vitamin D3 and Marine Omega-3 Fatty Acids Supplementation and Leukocyte Telomere Length: 4-Year Findings from the VITAL Randomized Controlled Trial,The American Journal of Clinical Nutrition,2025
2025-05-2413 min
The Journal ClubBiological Markers for Teen DepressionAlice Morgunova, Nicholas O’Toole, Fatme Abboud, Saché Coury, Gary Gang Chen, Maxime Teixeira, Eamon Fitzgerald, Gustavo Turecki, Anthony J. Gifuni, Ian H. Gotlib, Corina Nagy, Michael J. Meaney, Tiffany C. Ho, Cecilia Flores,Peripheral microRNA signatures in adolescent depression,Biological Psychiatry Global Open Science,2025,
2025-05-2414 min
The Journal ClubMuscle Quality as a Marker for Early Cognitive Decline in AdultsIkeue K, Kato H, Tanaka M, Yamakage H, Kato S, Iwasa M, Oishi K, Yamamoto Y, Kanasaki M, Masuda I, Ishii K, Satoh-Asahara N. Phase Angle Is a Potential Novel Early Marker for Sarcopenia and Cognitive Impairment in the General Population. J Cachexia Sarcopenia Muscle. 2025 Jun
2025-05-2411 min
The Journal ClubMath and biology meet in the cerebellumMohammad Amin Fakharian et al., A vector calculus for neural computation in the cerebellum. Science 388, 869-875 (2025)
2025-05-2214 min
The Journal ClubThe emergence and demise of giant slothsAlberto Boscaini et al. ,The emergence and demise of giant sloths.Science 388,864-868(2025)
2025-05-2219 min
The Journal ClubTurf algae redefine the chemical landscape of temperate reefs, limiting kelp forest recoveryShane P. Farrell et al. ,Turf algae redefine the chemical landscape of temperate reefs, limiting kelp forest recovery.Science388,876-880(2025)
2025-05-2213 min
The Journal ClubHealth impacts of exposure to synthetic chemicals in foodMuncke, J., Touvier, M., Trasande, L. et al. Health impacts of exposure to synthetic chemicals in food. Nat Med 31, 1431–1443 (2025)
2025-05-2222 min
The Journal ClubEleanor Maguire (1970–2025)Price, C.J., Zeidman, P. & Callaghan, M.F. Eleanor Maguire (1970–2025). Nat Neurosci (2025).
2025-05-2209 min
The Journal ClubA dynamic and multimodal framework to define microglial statesSankowski, R., Prinz, M. A dynamic and multimodal framework to define microglial states. Nat Neurosci (2025)
2025-05-2218 min
The Journal ClubWidespread brain–body integration during changes of arousalWidespread brain–body integration during changes of arousal. Nat Neurosci (2025).
2025-05-2213 min
The Journal ClubA basic role for glia in sleep homeostasisKirszenblat, L., van Swinderen, B. A basic role for glia in sleep homeostasis. Nat Neurosci (2025)
2025-05-2213 min
The Journal ClubMicroglia and T Cells Drive White Matter AgingMonteiro, J.K., Miron, V.E. Microglia conduct the symphony of white matter degeneration in aging through T cell recruitment. Nat Neurosci (2025)
2025-05-2214 min
The Journal ClubNeuronal Senescence in Dorsal Root Ganglia and PainDonovan, L.J., Brewer, C.L., Bond, S.F. et al. Aging and injury drive neuronal senescence in the dorsal root ganglia. Nat Neurosci 28, 985–997 (2025)
2025-05-2219 min
The Journal ClubmGluR5 Mediates Activity-Driven Myelin Sheath GrowthBraaker, P.N., Mi, X., Soong, D. et al. Activity-driven myelin sheath growth is mediated by mGluR5. Nat Neurosci (2025)
2025-05-2219 min
The Journal ClubCysteine Deficiency Drives Weight Loss by Depleting coenzyme AVarghese, A., Gusarov, I., Gamallo-Lana, B. et al. Unravelling cysteine-deficiency-associated rapid weight loss. Nature (2025)
2025-05-2220 min
The Journal ClubInsulin Resistance may be a factor linking Alzheimer's and epilepsyAlves SS, Servilha-Menezes G, Rossi L, de Oliveira JAC, Grigorio-de-Sant'Ana M, Sebollela A, da Silva-Junior RMP, Garcia-Cairasco N. Insulin signaling disruption exacerbates memory impairment and seizure susceptibility in an epilepsy model with Alzheimer's disease-like pathology. J Neural Transm (Vienna). 2025 Feb 22
2025-05-2211 min
The Journal ClubGenomic Study of Long COVID Finds FOXP4 LinkGenomic Study of Long COVID Finds FOXP4 Link
2025-05-2213 min
The Journal ClubAstrocytic PERK Inhibition Restores Glymphatic Function in ADKai Chen, Yosuke M. Morizawa, Tal Nuriel, Osama Al-Dalahmah, Zhongcong Xie, Guang Yang,Selective removal of astrocytic PERK protects against glymphatic impairment and decreases toxic aggregation of β-amyloid and tau,Neuron, 2025
2025-05-2213 min
The Journal ClubHow poverty and loneliness are linked to pain, fatigue, and low moodDavis AJ, Cohen E, Nettle D. Associations amongst poverty, loneliness, and a defensive symptom cluster characterised by pain, fatigue, and low mood. Public Health. 2025 May
2025-05-2211 min
The Journal ClubPredicting Postpartum Depression Risk Before DischargeClapp MA, Castro VM, Verhaak P, McCoy TH, Shook LL, Edlow AG, Perlis RH. Stratifying Risk for Postpartum Depression at Time of Hospital Discharge. Am J Psychiatry. 2025 May 19
2025-05-2116 min
The Journal ClubNucleus Accumbens Dopamine Predicts Future Defensive ActionsFisher AA, Gonzalez LS, Cappel ZR, Grover KE, Waclaw RR, Robinson JE. Dopaminergic encoding of future defensive actions in the mouse nucleus accumbens. PNAS Nexus. 2025 Apr 29
2025-05-2111 min
The Journal ClubDon't hit the snooze button when waking upRobbins, R., Sääf, D., Weaver, M.D. et al. Snooze alarm use in a global population of smartphone users. Sci Rep 15
2025-05-2113 min
The Journal ClubInflammation tied to motivation deficits in schizophreniaGoldsmith, D.R., Ning, C.S., Strauss, G.P. et al. Inflammation is associated with avolition and reduced resting state functional connectivity in corticostriatal reward circuitry in patients with schizophrenia. Neuropsychopharmacol. (2025)
2025-05-2112 min
The Journal ClubQuantifying the lifespan of synaptic proteins during learning using DeltaMohar, B., Michel, G., Wang, YZ. et al. DELTA: a method for brain-wide measurement of synaptic protein turnover reveals localized plasticity during learning. Nat Neurosci 28
2025-05-2114 min
The Journal ClubHippocampal Replay Composes Future BehaviorBakermans, J.J.W., Warren, J., Whittington, J.C.R. et al. Constructing future behavior in the hippocampal formation through composition and replay. Nat Neurosci 28
2025-05-2137 min
The Journal ClubLinking brain inflammation to repetitive behaviors in Autism and OCDJung H, Kim B, Jang G, Kim H, Lee AR, Yoon SH, Lee KS, Hyun G, Kim Y, Ko J, Yu JW, Um JW. The NLRP3 inflammasome in microglia regulates repetitive behavior by modulating NMDA glutamate receptor functions. Cell Rep. 2025 May 6
2025-05-2111 min
The Journal ClubCancer Needs Neuroscience and NeuroscientistsMonje M, Winkler F. Cancer research needs neuroscience and neuroscientists. Nat Neurosci. 2025 May;28
2025-05-1821 min
The Journal ClubWhy Women have faster heart rates than MenLi N, Webb A, Kennelly J, Sharma R, Whitson BA, Mohler PJ, Hummel JD, Zhao J, Fedorov V. Heart Rate Mystery Unveiled: Sex Differences in Human Sinoatrial Node Genes and Female Tachycardia. Circ Arrhythm Electrophysiol. 2025 Apr 23
2025-05-1716 min
The Journal ClubFirst-of-Its-Kind mRNA Therapy Corrects Rare Metabolic Mutation in InfantMusunuru K, Grandinette SA, Wang X, Hudson TR, Briseno K, Berry AM, Hacker JL, Hsu A, Silverstein RA, Hille LT, Ogul AN, Robinson-Garvin NA, Small JC, McCague S, Burke SM, Wright CM, Bick S, Indurthi V, Sharma S, Jepperson M, Vakulskas CA, Collingwood M, Keogh K, Jacobi A, Sturgeon M, Brommel C, Schmaljohn E, Kurgan G, Osborne T, Zhang H, Kinney K, Rettig G, Barbosa CJ, Semple SC, Tam YK, Lutz C, George LA, Kleinstiver BP, Liu DR, Ng K, Kassim SH, Giannikopoulos P, Alameh MG, Urnov FD, Ahrens-Nicklas RC. Patient-Specific In Vivo Gene Editing to Treat a Rare...
2025-05-1715 min
The Journal ClubCaffeine consumption might protect against cognitive decline and of Alzheimer’s diseaseAshfaq Z, Younas Z, Nathaniel E, Rehman A, Siddiqi A, Rasool N, Amir M. Association Between Caffeine Intake and Alzheimer's Disease Progression: A Systematic Review. Cureus. 2025 Mar 20
2025-05-1715 min
The Journal ClubCOVID Brain Fog May Have a Biological Trigger, Study FindsLawrence MR, Arnetz JE, Counts SE, Ahmed A, Arnetz BB. Self-reported health, neuropsychological tests and biomarkers in fully recovered COVID-19 patients vs patients with post-COVID cognitive symptoms: A pilot study. PLoS One. 2025 May 15
2025-05-1714 min
The Journal ClubSYNGAP1 Roles in Excitability and Seizure SusceptibilityBrill J, Clarke B, Hong I, Huganir RL. Dissociation of SYNGAP1 enzymatic and structural roles: Intrinsic excitability and seizure susceptibility. Proc Natl Acad Sci U S A. 2025 May 6
2025-05-1712 min
George Brauchler DA Podcast #1: Meet DA George BrauchlerPodcast #6 Meet Chief Deputy DA Danielle JaramilloWelcome to the George Brauchler DA Podcast—your front-row seat to the world of true crime, seen through the eyes of one of Colorado's most seasoned prosecutors.
In today's episode, we meet Chief Deputy District Attorney Danielle Jaramillo—a sex crimes prosecutor who has faced down some of the most heinous offenders in the state. From a tough upbringing in Utah to becoming a standout soccer player at the U.S. Air Force Academy, Danielle's journey took a sharp turn when career-ending injuries led her away from athletics and into the world of law.
Danielle shar...
2025-05-0238 minGeorge Brauchler DA Podcast #1: Meet DA George BrauchlerGeorge Brauchler DA Podcast #6: Meet Chief Deputy DA Danielle JaramilloWelcome to the George Brauchler DA Podcast- your front row seat to the world of true crime through the lens of one of Colorado's most experienced prosecutors. In today's episide we'll meet Chief Deputy District Attorney, Danielle Jaramillo- a sex crimes prosecutor who has faced down some of the most heinous criminals in the state. From a tough upbringing in Utah, to her journey to the U.S. Air Force Academy as a standout soccer player, Danielle's path took a sharp turn after career ending injries led her away from athletics and into the world of law.
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2025-05-0238 minGeorge Brauchler DA Podcast #1: Meet DA George BrauchlerGeorge Brauchler DA Podcast #6: Meet Chief Deputy DA Danielle JaramilloWelcome to the George Brauchler DA Podcast- your front row seat to the world of true crime through the lens of one of Colorado's most experienced prosecutors. In today's episide we'll meet Chief Deputy District Attorney, Danielle Jaramillo- a sex crimes prosecutor who has faced down some of the most heinous criminals in the state. From a tough upbringing in Utah, to her journey to the U.S. Air Force Academy as a standout soccer player, Danielle's path took a sharp turn after career ending injries led her away from athletics and into the world of law.
...
2025-05-0238 min
George Brauchler DA Podcast #1: Meet DA George BrauchlerGeorge Brauchler DA Podcast #6: Meet Chief Deputy DA Danielle JaramilloWelcome to the George Brauchler DA Podcast- your front row seat to the world of true crime through the lens of one of Colorado's most experienced prosecutors. In today's episide we'll meet Chief Deputy District Attorney, Danielle Jaramillo- a sex crimes prosecutor who has faced down some of the most heinous criminals in the state. From a tough upbringing in Utah, to her journey to the U.S. Air Force Academy as a standout soccer player, Danielle's path took a sharp turn after career ending injuries led her away from athletics and into the world of law.
...
2025-05-0238 min
Life List: A Birding PodcastTribute to Tom Johnson, a remarkable bird expert and humanIn our season finale, we pay tribute to Tom Johnson, a distinguished bird expert and an exceptional human being, who passed away unexpectedly in 2023. Tom was a guiding light in the birding community, known for his profound knowledge, infectious enthusiasm, and unwavering dedication to bird conservation and science. This episode features an interview with Tom, recorded shortly before his passing.Listen to the American Birding Association's podcast tribute to Tom here. Learn more about Tom's impact on the birding community here and here in these two remembrance articles. Imagine yourself birding with To...
2024-06-031h 21
The Book Leads: Impactful Books For Life & LeadershipEpisode 79: Tom Hine, CFP®, CFS®, MBA & His Book, The Balanced Wealth Approach: Secrets To Living Long And Living RichEpisode 79: Tom Hine, CFP®, CFS®, MBA & His Book, The Balanced Wealth Approach: Secrets To Living Long And Living Rich
In this episode, Tom, a CERTIFIED FINANCIAL PLANNER™, author, and founder and CEO of Capital Wealth Management, shares with me how there should be comparable focus on both wealth and health when it comes to our futures -- even in his field of wealth management.
Through his own journey in finance (the numbers) and karate, meditation, yoga (the physical and the mind), he demonstrates that he's living what he's preaching.
The message he shares with...
2023-12-041h 32
Warrior's Edge PodcastMike Jaramillo InterviewMike Jaramillo is a 5th degree black belt in Brazilian Jiu-Jitsu under Renzo Gracie and John Danaher. He also teaches advanced classes at Renzo Gracie Academy. We deep dive into BJJ training concepts, thought provoking training mindset, insight on his and John Danaher's approach to teaching, how he got into BJJ, Renzo's first school in the US and the early years, and much more!
2023-07-2454 min
Let's Speak Frankly - 3 minute English Listening and LearningRich guy TomSend us a textWhile listening Try to answer these 2 questions;Why did Tom lose his business?What did Tom do with his free time?Vocabulary;Fancy (adjective) - over the top in structure or decoration.Lavish (adjective) - rich, elaborate, or luxuriousShow off (phrasal verb) - display someone or something that is a source of pride.Bankrupt (adjective) - (of a person or organization) declared in law as unable to pay their
2023-04-0202 min