Shows
Better BiopharmaThe Editors’ Roundtable: A 2025 Retrospective Of The Life Science IndustryIn this special edition of “Better Biopharma,” host Tyler Menichiello is joined by fellow chief editors from across the Life Science Connect ecosystem to reflect on the year and share their industry outlooks for 2026. This editorial roundtable features Katie Anderson, chief editor at Pharmaceutical Online; Jeff Buguliskis, Ph.D., deputy chief editor at Outsourced Pharma; Ben Comer, chief editor at Life Science Leader and host of The Business Of Biotech podcast; Ray Dogum, chief editor at Drug Discovery Online; Erin Harris, chief editor at Cell & Gene and host of Cell & Gene: The Podcast; and Anna Rose Welch, chief editor at A...
2025-12-311h 20Better BiopharmaCombining AI With Operations Research To Advance Biomanufacturing With Tinglong Dai, Ph.D., and Tugce Martagan, Ph.D.In this episode of “Better Biopharma,” host Tyler Menichiello is joined by Tinglong Dai, Ph.D., Bernard T. Ferrari Professor of Business at Johns Hopkins University, and Tugce Martagan, Ph.D., associate professor at Northeastern University, to talk about the potential advancements that can be made in biomanufacturing by combining AI with operations research (OR). You can check out their recent paper on the subject, “Synergizing Artificial Intelligence And Operations Research For Advancements In Biomanufacturing,” here: https://link.springer.com/epdf/10.1007/s10729-025-09725-7?sharing_token=RsWPImKggnLuwsztf7Y1S_e4RwlQNchNByi7wbcMAY7x0AE_Vqj5xOwaldIl63JrPLRzcTIZn-7Iu6LEV-lGtf...
2025-12-1735 minBetter BiopharmaBuilding An Oral Vaccine Platform With Vaxart's Sean Tucker, Ph.D.In this episode of “Better Biopharma,” host Tyler Menichiello is joined by Sean Tucker, Ph.D., founder and chief scientific officer at Vaxart, a company developing oral recombinant pill vaccines. They discuss Vaxart’s manufacturing process and how it differs from traditional biopharmaceutical production, as well as the regulatory considerations around its oral vaccines.Follow Tyler Menichiello on LinkedIn: https://www.linkedin.com/in/tmenichiello/Keep up with everything biomanufacturing at Bioprocess Online: https://www.bioprocessonline.com/Subscribe to our newsletters: https://www.bioprocessonline.com/user/edit/subscriptions
2025-12-0328 minBetter BiopharmaLessons In Scaling Regenerative Medicine Manufacturing With Organogenesis's Patrick BilboIn this episode of "Better Biopharma," Tyler Menichiello is joined by Patrick Bilbo, chief operating officer at Organogenesis, a regenerative medicine company developing and manufacturing advanced wound care products. They discuss the construction of Organogenesis's new facility in Rhode Island, as well as how the industry has changed in the company's 40-year history.Follow Tyler Menichiello on LinkedIn: https://www.linkedin.com/in/tmenichiello/Keep up with everything biomanufacturing at Bioprocess Online: https://www.bioprocessonline.com/Subscribe to our newsletters: https://www.bioprocessonline.com/user/edit/subscriptions
2025-11-1843 minBetter BiopharmaNavigating The Complexity of Conditionally Active Biologics With Bonum Therapeutics' Diane Hollenbaugh, Ph.D., and Neela Patel, Ph.D.In this episode of "Better Biopharma," host Tyler Menichiello is joined by Bonum Therapeutics' chief scientific officer, Diane Hollenbaugh, Ph.D., and chief business officer, Neela Patel, Ph.D. They talk about the inherent challenges of developing complex molecules like conditionally active biologics, sharing advice on CMC strategy, analytical methodology, and working with contract manufacturing and development partners.Follow Tyler Menichiello on LinkedIn: https://www.linkedin.com/in/tmenichiello/Keep up with everything biomanufacturing at Bioprocess Online: https://www.bioprocessonline.com/Subscribe to our newsletters: https://www.bioprocessonline.com/user/edit/subscriptions
2025-11-0547 minBetter BiopharmaDeveloping Antibodies To Block Neuroinflammation With MindImmune's Stevin Zorn, Ph.D.In this episode of "Better Biopharma," host Tyler Menichiello is joined by MindImmune's president and CEO, Stevin Zorn, Ph.D. They discuss the development of the company's lead candidate, MITI-101, a monoclonal antibody designed to prevent peripheral immune cells from entering the brain and driving neuroinflammation linked to Alzheimer's disease.Follow Tyler Menichiello on LinkedIn: https://www.linkedin.com/in/tmenichiello/Keep up with everything biomanufacturing at Bioprocess Online: https://www.bioprocessonline.com/Subscribe to our newsletters: https://www.bioprocessonline.com/user/edit/subscriptions
2025-10-2244 minBetter BiopharmaEngineering Bacterial Vector-Based Immunotherapies With OS Therapies’ Paul Romness and Robert Petit, Ph.D.In this episode of “Better Biopharma,” host Tyler Menichiello is joined by OS Therapies’ CEO, Paul Romness, and chief medical and scientific officer, Robert Petit, Ph.D. The three discuss the development and manufacturing of the company’s lead asset, OST-HER2, a Listeria-based immunotherapy for osteosarcoma. They also explain the unique CMC challenges around developing a safe bacterial vector.Follow Tyler Menichiello on LinkedIn: https://www.linkedin.com/in/tmenichiello/Keep up with everything biomanufacturing at Bioprocess Online: https://www.bioprocessonline.com/Subscribe to our newsletters: https://www.bioprocessonline.com/user/edit/subscriptions
2025-10-0836 minBetter BiopharmaHow J&J Is Tackling Alzheimer's Disease With Fiona Elwood, Ph.D.In this episode of “Better Biopharma,” host Tyler Menichiello is joined by Fiona Elwood, Ph.D., VP and Neurodegeneration Disease Area Stronghold Leader at Johnson & Johnson. The two talk about J&J’s end-to-end organizational structure and its modality-agnostic approach to treating Alzheimer’s disease.Follow Tyler Menichiello on LinkedIn: https://www.linkedin.com/in/tmenichiello/Keep up with everything biomanufacturing at Bioprocess Online: https://www.bioprocessonline.com/Subscribe to our newsletters: https://www.bioprocessonline.com/user/edit/subscriptions
2025-09-2432 minBetter BiopharmaCDMO Hunger Games And The State Of Biotech With Siren Biotechnology's Nicole Paulk, Ph.D.In this episode of “Better Biopharma,” host Tyler Menichiello is joined by Nicole Paulk, Ph.D., CEO and founder of Siren Biotechnology, a company developing a universal AAV immuno-gene therapy for cancer. They discuss the company’s decision to switch from plasmids to producer cell lines (PCLs) in production, the current funding environment for cell and gene therapies (CGTs), how companies are innovating and doing more with less, and the unconventional head-to-head competition that determined which CDMO won Siren’s business.Follow Tyler Menichiello on LinkedIn: https://www.linkedin.com/in/tmenichiello/Keep up with everythi...
2025-09-101h 00Better BiopharmaDelivering Biologics To The Brain With Adaptin Bio's Michael Roberts, Ph.D., and Duke University's Mustafa Khasraw, MDIn this episode of "Better Biopharma," host Tyler Menichiello is joined by Adaptin Bio's CEO, co-founder, and president, Michael Roberts, Ph.D., and Duke University's Mustafa Khasraw, MD. They discuss Adaptin's Brain Bispecific T-cell Engager (BRiTE) platform, its clinical potential to deliver therapeutic T cells across the blood-brain barrier, and the development and manufacturing challenges behind the company's lead asset, APTN-101. Follow Tyler Menichiello on LinkedIn: https://www.linkedin.com/in/tmenichiello/Keep up with everything biomanufacturing at Bioprocess Online: https://www.bioprocessonline.com/Subscribe to our newsletters: https://www.bioprocessonline.com/user/e...
2025-08-2736 minBetter BiopharmaDeveloping An In Vivo CAR-T With Interius BioTherapeutics' Sianny Christanti and Babu Medi, Ph.D.On this episode of Better Biopharma, Interius BioTherapeutics’ Sianny Christanti and Babu Medi, Ph.D., explain how the company is re-engineering a lentiviral vector to enable INT2104, its off-the-shelf, in vivo CAR T-cell therapy. They discuss the vector's design and its manufacturability, as well as the analytical and regulatory challenges of bringing this first-in-human therapy to the clinic.Follow Tyler Menichiello on LinkedIn: https://www.linkedin.com/in/tmenichiello/Keep up with everything biomanufacturing at Bioprocess Online: https://www.bioprocessonline.com/Subscribe to our newsletters: https://www.bioprocessonline.com/user/edit/subscriptions
2025-08-1348 minBetter BiopharmaFunctional Antibody Screening With Abalone Bio's Richard Yu, Ph.D.In this episode of Better Biopharma, Abalone Bio's CEO and co-founder, Richard Yu, Ph.D., explains how the company's functional antibody selection technology (FAST) platform differs from traditional affinity screening.Follow Tyler Menichiello on LinkedIn: https://www.linkedin.com/in/tmenichiello/Keep up with everything biomanufacturing at Bioprocess Online: https://www.bioprocessonline.com/Subscribe to our newsletters: https://www.bioprocessonline.com/user/edit/subscriptions
2025-07-3043 minBetter BiopharmaUsing Algae To Manufacture Oral Biologics With Lumen Bioscience's Craig Behnke, Ph.D.Lumen Bioscience is putting the farm in biopharma — literally! In this episode of Better Biopharma, Lumen's EVP of production and development, Craig Behnke, Ph.D., explains the company's chlorophyll-powered approach to bioprocessing using photosynthetic cyanobacteria.Check out Behnke's past appearance on Business Of Biotech: https: //www.lifescienceleader.com/doc/democratizing-biologics-with-lumen-bioscience-s-brian-finrow-j-d-craig-behnke-ph-d-0002Follow Tyler Menichiello on LinkedIn: https://www.linkedin.com/in/tmenichiello/Keep up with everything biomanufacturing at Bioprocess Online: https://www.bioprocessonline.com/Subscribe to our newsletters: https://www.bioprocessonline.com/user/edit/subscriptions
2025-07-1644 minBetter BiopharmaPILOT: Introducing Better BiopharmaHow can the biopharmaceutical industry improve? Join Bioprocess Online's Tyler Menichiello as he explores this question through a series of interviews with experts and leaders from across the space. Subscribe for biweekly, in-depth conversations with the brightest minds in biotech to learn how they're moving the needle to make better medicines and optimize manufacturing.Follow Tyler Menichiello on LinkedIn: https://www.linkedin.com/in/tmenichiello/Keep up with everything biomanufacturing at Bioprocess Online: https://www.bioprocessonline.com/Subscribe to our newsletters: https://www.bioprocessonline.com/user/edit/subscriptions
2025-07-1602 min