Shows
This Week in ParasitismOur hero Dickson TWiP explains a study which finds that tissue spaces are reservoirs of antigenic diversity for Trypanosoma brucei, then remembers our departed colleague Dickson Despommier. Hosts: Vincent Racaniello, Daniel Griffin, and Christina Naula Click arrow to play Download TWiP #254 (88 MB .mp3, 61 minutes) Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Links for this episode Join the MicrobeTV Discord server Tissue spaces are reservoirs of antigenic diversity for T. brucei (Nature) Understanding trypanosome antigenic variation (Emerg Top Life Sci) Tissue resident T. brucei (PLoS Path) Hero – Dickson Despommier Despommier Photo Art Parasitology Course (YouTube) Become a patron o...
2025-03-091h 00
This Week in VirologyClinical update with Dr. Daniel GriffinIn his weekly clinical update, Dr. Griffin briefly discusses the E.coli outbreak associated with onions from McDonald’s before deep diving into the announcement of Robert F Kennedy Jr. nomination for Secretary of Human and Health Services with highlights from MicrobeTV’s own Vincent Racaniello and Paul Offit (Beyond the Noise), the global measles outbreak, underutilization of influenza antivirals for children and teens, the $350 million 2025 order for mpox vaccination, before reviewing the recent statistics on SARS-CoV-2 infection, the WasterwaterScan dashboard, the effectiveness of N95 mask, the interplay between transmission and immunity for virus spread, where to find PEMGARDA, and tra...
2024-11-231h 02This Week in VirologyClinical update with Dr. Daniel GriffinIn his weekly clinical update, Dr. Griffin briefly discusses the E.coli outbreak associated with onions from McDonald’s before deep diving into the announcement of Robert F Kennedy Jr. nomination for Secretary of Human and Health Services with highlights from MicrobeTV’s own Vincent Racaniello and Paul Offit (Beyond the Noise), the global measles outbreak, underutilization of influenza antivirals for children and teens, the $350 million 2025 order for mpox vaccination, before reviewing the recent statistics on SARS-CoV-2 infection, the WasterwaterScan dashboard, the effectiveness of N95 mask, the interplay between transmission and immunity for virus spread, where to find PEMGARDA, and tra...
2024-11-231h 02
Matters MicrobialMatters Microbial: A microbiological introduction and a chat with Vincent RacanielloIn the first episode of Matters Microbial, Mark introduces himself and his history, talks a bit about his goals for this podcast, then asks three important questions about microbiology and microbiologists with his first guest, Vincent Racaniello. Host: Mark O. Martin Guest: Vincent Racaniello Become a patron of Matters Microbial! Links for this episode MicrobeTV Discord Server Virology blog MicrobeTV on YouTube Intro music is by Reber Clark Send your questions and comments to mattersmicrobial@gmail.com
2023-08-0740 min
This Week in VirologyAnother year is viralIn the first epitope of 2023, TWiV reviews our coverage of virology in 2022, including favorite story arcs, episodes, show titles, and much more. Hosts: Vincent Racaniello, Dickson Despommier, Rich Condit, Kathy Spindler, and Brianne Barker Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Our favorite 2022 virology stories: •Vincent: Paul Offit on bivalent boosters (TWiV 917, 942, Special) •Dickson: Interviews with Paul Offit and Andy Slavitt •Rich: TWiV 948: Breathless with David Quammen •Kathy: TWiV 915: Mouse mouth to mouse mom •Brianne: Spillovers (TWiV 92...
2023-01-011h 53
This Week in EvolutionOne-step symbiosisNels and Vincent describe how a single amino acid change can allow E. coli to replace the essential gut symbiont of the stinkbug Plautia stali. Hosts: Nels Elde and Vincent Racaniello Click arrow to play Download TWiEVO 75 (103 MB .mp3, 86 min) Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiEVO Links for this episode Making E. coli an insect mutualist (bioRxiv) Letters read on TWiEVo 76 Time stamps by Jolene. Thanks! Science Picks Nels – Inequality in science and the case for a new agenda...
2022-03-221h 25This Week in EvolutionEven the BANAL coronaviruses are interestingNels and Vincent review isolation of SARS-CoV-2-like viruses from bats in Laos that can replicate in human cells. Hosts: Nels Elde and Vincent Racaniello Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiEVO Links for this episode SARS-CoV-2 like viruses in bats in Laos (Nature) Vampire vax (TWiV 809) Time stamps by Jolene. Thanks! Science Picks Nels – Erich Jarvis on scientists and public engagement Vincent – Polio type 1 in Africa Music on TWiEVO is performed by Trampled by Turtles Send your evol...
2022-02-241h 38This Week in EvolutionOn racism, not race with Joe GravesJoe Graves joins Nels and Vincent to discuss his career in evolutionary biology and his recent book that answers questions about race and racism. Hosts: Nels Elde and Vincent Racaniello Guest: Joe Graves Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiEVO Links for this episode On Racism, Not Race (Amazon) African Americans in evolutionary science (Behav Ecol Sociobiol) Biological variation and the normal (Am J Hum Biol) Time stamps by Jolene. Thanks! Science Picks Nels – Where is Webb? Vincent – Black Microbiologists Association
2022-02-031h 25This Week in VirologyTree man syndromeA TWiV threesome explains the observation that humans with inherited T cell CD28 deficiency are susceptible to severe warts driven by human papilloma virus infection, but are otherwise healthy. Hosts: Vincent Racaniello, Rich Condit, and Brianne Barker Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Vaccine Town Hall (ASV) Travel Award Applications (ASV) CD28 deficiency and severe warts (Cell) Vincent interviews Harald zur Hausen (virology blog) Letters read on TWiV 853 Timestamps by Jolene. Thanks! Weekly Picks Brianne – Every Pore on Your Fa...
2022-01-131h 44This Week in EvolutionWith a little help from your hostsNels and Vincent review three aspects of SARS-CoV-2: phylogenetics of Omicron, a two-step fitness selection for variants, and putative RNA insertions from host genomes. Hosts: Nels Elde and Vincent Racaniello Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiEVO Links for this episode Two-step fitness selection for SARS-CoV-2 variants (Cell Rep) Host origins of SARS-CoV-2 genome insertions (Virological) Time stamps by Jolene. Thanks! Science Picks Nels – Plant virus satellite accelerates wing formation in insect Vincent – A plant virus that switched to vertebrates Music on TW...
2021-12-281h 36This Week in EvolutionEchoes of evolution both shallow and deepNels and Vincent discuss evolutionary evidence for an epidemic of coronavirus infection over 20,000 years ago in East Asia, and reconstruction of the membrane differences between bacteria and Archaea reveals unexpected differences in permeability. Hosts: Nels Elde and Vincent Racaniello Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiEVO Links for this episode Ancient coronavirus epidemic in East Asia (Curr Biol) Gene-culture coevolution and human evolutionary transition (Proc Roy Soc B) Membrane permeability at the lipid divide (bioRxiv) Time stamps by Jolene. Thanks! Science Picks Nels – Sl...
2021-10-261h 15This Week in VirologyPublic clonotype #1A TWiV trio reveal the isolation of novel paramyxoviruses from rodents and bats in Arizona, and isolation of naive B cells from seronegative donors that produce germline encoded antibodies which engage the receptor binding domain of SARS-CoV-2, variants of concern, and related sarbecoviruses from bats. Hosts: Vincent Racaniello, Rich Condit, and Brianne Barker Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Bat and rodent paramyxoviruses from Arizona (J Viral) Naive B cells engage SARS-CoV-2 RBD (Science Immunol) Vincent interviews Philip Sharp (ASM) Letters...
2021-10-242h 00This Week in EvolutionFaster than a speeding coronavirusNels and Vincent explain a method to calculate the mutation rate of SARS-CoV-2, and the role of a single amino acid change in spike in enhancing fitness of the delta variant and enabling it to out-compete the alpha variant. Hosts: Nels Elde and Vincent Racaniello Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiEVO Links for this episode SARS-CoV-2 mutation rate (Genome Biology Evolution) Delta spike change enhances fitness (bioRxiv) Time stamps by Jolene. Thanks! Science Picks Nels – Leading Edge Symposium Vincent – Epidemiological and evolution...
2021-09-271h 27This Week in EvolutionSwimming in SARS-CoV-2 sequencesNels and Vincent discuss the identification of novel bat coronaviruses that shed light on the evolution of SARS-CoV-2, dating the first cases of COVID-19 to mid-November 2019, and recovery of deleted genome sequences from early in the Wuhan outbreak. Hosts: Nels Elde and Vincent Racaniello Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiEVO Links for this episode Identification of novel bat coronaviruses (Cell) Dating first cases of COVID-19 (PLoS Path) Recovery of deleted SARS-CoV-2 sequences (bioRxiv) Time stamps by Jolene. Thanks! Science Picks Nels – The Last—An...
2021-06-301h 30This Week in EvolutionStepping through time with SARS-CoV-2Nels and Vincent explain a new method for calculating the most recent common ancestor of SARS-CoV-2, which concludes that the ancestral virus was circulating in October/November 2019, before its first detection in China. Hosts: Nels Elde and Vincent Racaniello Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiEVO Links for this episode Evolutionary portrait of SARS-CoV-2 (Mol Biol Evolution) Letters read on TWiEVO 68 Time stamps by Jolene. Thanks! Science Picks Nels – Ed Yong pandemic trauma and We’re Not Ready for the Next Pandemic Vincent...
2021-05-291h 33This Week in EvolutionCorona chameleonNels and Vincent review evidence for recombinant SARS-CoV-2 genomes arising in the B.1.1.7 lineage within the United Kingdom. Hosts: Nels Elde and Vincent Racaniello Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiEVO Links for this episode Recombination in B.1.1.7 lineage (Virological) CoVariants Letters read on TWiEVO 67 Time stamps by Jolene. Thanks! Science Picks Nels – Mars rover helicopter flight! Vincent – TWiN 17: Worms see the light with Michael Nitabach Music on TWiEVO is performed by Trampled by Turtles Send your evolution ques...
2021-04-221h 36This Week in EvolutionSARS-2-mouseNels and Vincent review a preprint demonstrating that changes in the genomes of the SARS-CoV-2 variants B1.351 and P.1 allow the viruses to reproduce in mouse cells in culture and in laboratory mice. Hosts: Nels Elde and Vincent Racaniello Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiEVO Links for this episode Tony Schountz on TWiV 668 SARS-CoV-2 variants infect mice (bioRxiv) CoVariants Letters read on TWiEVO 66 Time stamps by Jolene. Thanks! Science Picks Nels – Billion years of plate tectonics Vincent – Sapiens a Graphic History by Yu...
2021-03-251h 33This Week in VirologyThe kids aren't alrightOn a TWiV tetramer, we review the ongoing outbreaks of Ebolavirus disease in DRC and Guinea, evidence that SARS-CoV-2 infections in children are far more prevalent than are being detected, and recent long COVID estimates from the UK. Hosts: Vincent Racaniello, Rich Condit, Alan Dove, and Brianne Barker Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Ebolavirus disease outbreak continues in Africa (ProMedMail) List of Ebolavirus outbreaks (Wikipedia) Ebolavirus genome sequences from Guinea (virological) Bias in reporting on childhood SARS-CoV-2 infections (Clinical Inf Dis...
2021-03-141h 54This Week in EvolutionVariants in the mistNels and Vincent review evidence that a single amino acid change in the SARS-CoV-2 spike protein has driven adaptation to humans, followed by an update on the status of variants of concern. Hosts: Nels Elde and Vincent Racaniello Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiEVO Links for this episode Selective sweep drove SARS-CoV-2 adaptation (bioRxiv) Novel coronavirus haplotypes Letters read on TWiEVO 65 Time stamps by Jolene. Thanks! Science Picks Nels – Radio Garden Vincent – Our World in Data – Coronavirus Music on TWiEVO is pe...
2021-02-251h 26This Week in EvolutionSeeing the lineages for the variantsNels and Vincent consider evolution of antibody immunity to SARS-CoV-2, and update the situation on novel virus variants of concern with potentially altered fitness and reactivity with antibodies. Hosts: Nels Elde and Vincent Racaniello Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiEVO Links for this episode Evolution of SARS-CoV-2 antibodies (Nature) mRNA vaccine-elicited antibodies to variants (bioRxiv) Scott Hensley thread (Twitter) Analysis of B.1.17 lineage (virological) Trevor Bedford thread (Twitter) Andrew Rambaut on variant naming (Twitter) Letters read on TWiEVO 64 Time stamps by Jolene. Thanks! Science P...
2021-01-221h 48This Week in EvolutionYear of the coronavirus Nels and Vincent wrap up 2020 with a discussion of novel variants of SARS-CoV-2 that have emerged in the United Kingdom and South Africa, how to interpret the rapidly emerging genome sequence data and what to look for in the coming weeks as these variants spread across the globe. Hosts: Nels Elde and Vincent Racaniello Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiEVO Links for this episode Preliminary genomic characterization of UK variant (virological) Clinical outcomes of infection with Orf8 variants (Lancet) Global Report Investigating Novel Coronavirus Haplotyp...
2020-12-311h 30This Week in EvolutionArmy ants with Daniel KronauerDaniel joins Nels and Vincent to discuss his new book on army ants, the wickedest insects ever to roam the planet, and his research on them and clonal raider ants. Hosts: Nels Elde and Vincent Racaniello Guest: Daniel Kronauer Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiEVO Links for this episode This Week in Ants (TWiEVO 13) Raiders of the Lost Orco (TWiEVO 18) Army Ants by Daniel Kronauer Time stamps by Jolene. Thanks! Science Picks Daniel – Desert Navigator by Rüdiger Wehner and Insects...
2020-12-071h 36This Week in EvolutionFive years of TWiEVO on the future of our pastOn the fifth anniversary of TWiEVO, Nels and Vincent invite 12 evolutionary biologists to describe exciting future directions for the field and their laboratory in the next five years. Hosts: Nels Elde and Vincent Racaniello Guests: Lillian Fritz Laylin, Talia Karasov, Andrew Kern, Sarah Tishkoff, Dmitri Petrov, Nancy Chen, Amanda Larracuente, John McCutcheon, Ambika Kamath, Chip Aquadro, Rebekah Rogers, Yaniv Braindvain, and Harmit Malik Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiEVO Science Picks Nels - Science Mill Virtual Tour and Benefit Vincent - Das Co...
2020-09-251h 50This Week in EvolutionThe hypothesis giving treeNels and Vincent answer listener questions and discuss a newly discovered virus of amoeba with a nearly complete ORFan genome: none of the proteins encoded in the viral genome look like any other proteins. Hosts: Nels Elde and Vincent Racaniello Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiEVO Links for this episode Yaravirus (PNAS) Letters read on TWiEVO 59 Time stamps by Jolene. Thanks! Science Picks Nels - Blog by Ambika Kamath Vincent - TWiVerse Music on TWiEVO is performed by Trampled...
2020-08-281h 27This Week in EvolutionRevising the drafts of coronavirus evolutionNels and Vincent continue their discussion of SARS-CoV-2 evolution, including understanding recurrent mutations in the viral genome, and the potential for re-emergence of the virus from an animal reservoir. Hosts: Nels Elde and Vincent Racaniello Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiEVO SARS-CoV-2 genomic diversity (Inf, Genet, Evol) Re-emergence of SARS-CoV-2 (bioRxiv) Tackling SARS-CoV-2 rumors (virological.org) Letters read on TWiEVO 56 Image credit Time stamps by Jolene. Thanks! Science Picks Nels - The Cell in Evolution Vincent - Visual Science Music on TWiEV...
2020-05-201h 28This Week in EvolutionCoronavirus evolution from soup to nutsNels and Vincent continue their discussion of SARS-CoV-2 evolution, with a report that the coronavirus proofreading enzyme stimulates RNA recombination, and debunking the conclusion that a change in the viral spike glycoprotein is associated with increased human to human transmission. Hosts: Nels Elde and Vincent Racaniello Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiEVO CoV proofreading enzyme stimulates recombination (bioRxiv) CoV spike mutation pipeline (bioRxiv) Issues with CoV sequencing data (virological.org) Bill Hanage on selection vs bottleneck (threader.app) Image credit Time stamps by Jolene. Thanks! Science...
2020-05-061h 13This Week in EvolutionRough drafts of SARS-CoV-2 scienceNels and Vincent continue their discussion of SARS-CoV-2 from an evolutionary viewpoint, including function of the furin cleavage site, whether Vervet cells are an informative system, another bat isolate, and a nomenclature to assist genomic epidemiology. Hosts: Nels Elde and Vincent Racaniello Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiEVO SARS-CoV-2 in Vero cells (bioRxiv) More related SARSr virus from bat (bioRxiv) Patient isolates in Vero cells (medRxiv) Nomenclature for genomic epidemiology (bioRxiv) Time stamps by Jolene. Thanks! Science Picks Nels - EvoEco seminars Vincent...
2020-04-251h 17This Week in EvolutionVirus evolution by land and by sea and by CoV, part IINels and Vincent continue their discussion of SARS-CoV-2 from an evolutionary viewpoint, focusing on what the genome sequences tell us about the virus. Hosts: Nels Elde and Vincent Racaniello Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiEVO Clement Chow with COVID-19 (Salt Lake Trib) Scientists exposed to coronavirus (Nature) CoV by Britt Glaunsinger (YouTube) Genetic epidemiology of novel coronavirus (nextstrain.org) Time stamps by Jolene. Thanks! Science Picks Nels - Science Mill Explorer Zone Vincent - COVID-19 treatment and therapy tracker Music on TWiEV...
2020-04-041h 31This Week in EvolutionVirus evolution by land and by sea and by CoVNels and Vincent examine SARS-CoV-2 from an evolutionary viewpoint, examining what the spike glycoprotein sequence informs us about the origin of the virus. Hosts: Nels Elde and Vincent Racaniello Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiEVO Distinct CoV name needed (Lancet) Proximal origin of SARS-COV-2 (virological) CoV spillovers not rare (Goats and Soda) SARS-CoV-2 phylodynamics analysis (virological) Bat CoV surveillance in China (PLoS Path) Image credit Time stamps by Jolene. Thanks! Science Picks Nels - Alejandro Sanchez TED Talk Vincent - WHO SARS-CoV-2 Sitrep
2020-02-261h 22This Week in EvolutionThe starting point paradoxNels and Vincent dive deep into evolution and consider how new proteins emerged billions of years ago, when there were no other proteins to serve as starting material. Hosts: Nels Elde and Vincent Racaniello Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiEVO Primordial emergence of a nucleic acid binding protein (bioRxiv) Tawfik laboratory Image credit Letters read on TWiEVO 51 Time stamps by Jolene. Thanks! Science Picks Nels - Universal principled review Vincent - Hostile Planet by National Geographic Listener Pick Courtney...
2020-01-221h 10This Week in EvolutionI'm dreaming of a Y chromosomeNels and Vincent discuss signatures of sex chromosome evolution revealed by assembly of a young vertebrate Y chromosome from 3-spined stickleback fish. Hosts: Nels Elde and Vincent Racaniello Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiEVO Assembly of a young vertebrate Y chromosome (bioRxiv) Image credit Letters read on TWiEVO 50 Time stamps by Jolene. Thanks! Science Picks Nels - Genome from a 5,700-Year-Old Wad of Chewed Gum Vincent - NJ Sea-Level Rise Reports Music on TWiEVO is performed by Trampled by Turtles Sen...
2019-12-241h 42This Week in EvolutionA giant podcast on giant virusesRich joins Nels and Vincent for a debriefing on the 4th Ringberg Symposium on Giant Virus Biology in Tegernsee, Germany. Hosts: Nels Elde and Vincent Racaniello Guest: Rich Condit Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiEVO Endless giant virus forms most beautiful (TWiV 575) 4th Ringberg Giant Virus Meeting Program (pdf) Photographs by Matthias Fischer Time stamps by Jolene. Thanks! Science Picks Rich - Flightradar24 Nels - Deutsches Museum Munich Vincent - Diversify Microbiology Music on TWiEVO is performed by Tramp...
2019-11-291h 53This Week in EvolutionFlipping out with choanos on caffeineNels and Vincent reveal a new choanoflagellate that forms multicellular cup shaped colonies that respond to light to alternate between feeding and swimming behavior. Hosts: Nels Elde and Vincent Racaniello Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiEVO Microbial accomplices in multicellularity (TWiEVO 11) Light regulated collective contractility (Science) Image credit Letters read on TWiEVO 48 Time stamps by Jolene. Thanks! Science Picks Nels - How to write a great science paper by Cormac McCarthy Vincent - Natural Selection Store Music on TWiEVO is performe...
2019-10-311h 34This Week in EvolutionOn the origin of beer speciesNels and Vincent trace the origins of Saccharomyces cerevisiae strains used to make beer, and find that ales and lagers are made with yeasts that were derived from those used to make European grape wine and Asian rice wine. Hosts: Nels Elde and Vincent Racaniello Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiEVO Origins of beer yeasts (PLoS Biol) Chateau Jiahu beer Time stamps by Jolene. Thanks! Science Picks Nels - Population fluctuations in 10 biggest cities Vincent - 1.7 million year old rhino tooth (original Nature pape...
2019-09-191h 31This Week in EvolutionCan an old tumor teach us new tricks?Nels and Vincent analyze the genomes of canine transmissible tumors to provide insight into the worldwide spread of the disease from its origin in a single dog 4000-8500 years ago, and its diversity, mutation, and evolution. Hosts: Nels Elde and Vincent Racaniello Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiEVO Evolution and mutation of canine transmissible cancer (Science) Clam cancers (TWiEVO 17) Sixth modality of infectious disease (PLoS Path) Time stamps by Jolene. Thanks! Science Picks Nels - Vasa Museum in Stockholm Vincent - Nobel Museum in S...
2019-08-311h 32This Week in EvolutionThe enemy of my enemy is my phageAt ASM Microbe in San Francisco, Nels and Vincent meet up with Paul Turner to talk about evolutionary considerations in using bacteriophages to treat infections with antibiotic-resistant bacteria. Hosts: Nels Elde and Vincent Racaniello Guest: Paul Taylor Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiEVO Turner Lab at Yale Phage therapy: A renewed approach (Cell Host Microbe) Phage treatment of aortic graft (Evol Med Pub Health) Time stamps by Jolene. Thanks! Science Picks Nels- Science Glass Vincent- Phage therapy for disseminated Mycobacte...
2019-06-271h 04This Week in EvolutionSocial evolution with a side of shrimpDustin Rubinstein joins Nels and Vincent to discuss coevolution of genome architecture and social behavior, and studying social transitions in sponge-dwelling snapping shrimp. Hosts: Nels Elde and Vincent Racaniello Guest: Dustin Rubinstein Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiEVO Co-evolution of genome architecture and social behavior (Trend Ecol Evol) Social transitions in snapping shrimp (Curr Op Insect Sci) Time stamps by Jolene. Thanks! Science Picks Dustin- Genesis: The Deep Origin of Societies 1 by E.O. Wilson, and The Human Swarm by Mark O. Moffett...
2019-05-251h 20This Week in EvolutionWho's who in your genomeNels and Vincent review the contribution of multiple Denisovan lineages to the modern Papuan genome. Hosts: Nels Elde and Vincent Racaniello Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiEVO Denisovan ancestries in Papuans (Cell) Prof Murray Cox Image credit Letters read on TWiEVO 42 Time stamps by Jolene. Thanks! Science Picks Nels- Sydney Brenner - What Genomes Can Tell Us About the PastVincent- Scientific Communication in a Post-Truth Society Music on TWiEVO is performed by Trampled by Turtles Send your evolution ...
2019-04-241h 18This Week in EvolutionWhere do baby genes come from?Nels and Vincent explore the evolution of new protein-coding genes de novo from nocoding DNA sequences, using the antifreeze protein of northern codfish as a model. Hosts: Nels Elde and Vincent Racaniello Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiEVO Evolution of antifreeze protein gene in codfish (PNAS) Codfish diversity (Cheng lab) Frankentomatoes (Huff Post) Image credit Time stamps by Jolene. Thanks! Science Picks Nels- Science at Sundance reviews Vincent- The Rise and Fall of Scientific Authority Music on TWiEVO is performed...
2019-03-201h 24This Week in EvolutionEau de beeNels and Vincent move back to reproductive isolation - this time, pre-zygotic, in the charismatic orchid bee where the males make chemically distinct perfumes to attract mates of the same species. Hosts: Nels Elde and Vincent Racaniello Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiEVO Olfactory receptor gene underlies reproductive isolation (biorXiv) Image credit Time stamps by Jolene. Thanks! Science Picks Nels- Nature Zen: Orchid Bees Are Shiny Vincent- What You Believe About Science Denial May Be All Wrong Music on TWiEVO is perfor...
2019-02-151h 11This Week in EvolutionIn a Legionella of their ownNels and Vincent look at the intracellular bacteria Legionella from an evolutionary perspective: the role of gene acquisition and reshuffling from plants, animals, fungi, and archaea in the emergence of human pathogens. Hosts: Nels Elde and Vincent Racaniello Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiEVO Over 18,000 effectors in Legionella genome (PNAS) Carmen Buchrieser lab Howard Shuman Science Picks Nels - Science in Film (twitter) Vincent - Lunar Eclipse 101 Music on TWiEVO is performed by Trampled by Turtles Send your evolution questions and comments to...
2019-01-261h 17This Week in EvolutionEvolving to evolveNels and Vincent reveal a highly conserved protein that acts as an evolvability factor, increasing mutation and the ability of bacteria to become resistant to antibiotics. Hosts: Nels Elde and Vincent Racaniello Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiEVO Inhibiting evolution of antibiotic resistance (Mol Cell) Pushing viruses over the error threshold (virology blog) Image credit Letters read on TWiEVO 38 Science Picks Nels- Science/nature illustrator/artist Rachel Ignotofsky (website, Etsy shop) Vincent- Life Ascending by Nick Lane Music on TWiEVO is performe...
2018-12-241h 20This Week in VirologySlicing and dicing with RaulRaul Andino joins Vincent and Amy to talk about the finding that a cricket paralysis virus protein restricts RNA-based immunity in insects by regulating the activity and stability of the Argonaute protein. Hosts: Vincent Racaniello and Amy Rosenfeld Guest: Raul Andino Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode TWiV 138: RISCy business with Raul Andino TWiV 33: Live in Philly Viral protein restricts insect immunity (Cell Host Micr) Timestamps by Jolene. Thanks! Weekly Science Picks Amy - Insectropolis Vincen...
2018-12-121h 16This Week in VirologyJust in time for HalloweenBrianne and Vincent tackle two studies that utilize infectious viruses to examine zoonotic potential of Bombali virus, a new ebolavirus from an insectivorous species in Sierra Leone, and a human mumps-like virus from an African flying fox in DRC. Hosts: Vincent Racaniello and Brianne Barker Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Pan American Society for Clinical Virology San Diego and Houston Regional Meetings It's not SARS 2.0 (TWiV 364) Bats out of hell (TWiV 183) Bombali virus, a new Ebolavirus (Nat Micro) Asymptomatic Ebolaviru...
2018-10-281h 19This Week in EvolutionAll's not quiet on the telomeric frontMia joins Nels and Vincent to unravel their finding that the transposons that maintain the ends of chromosomes in Drosophilahave evolved in conflict with the genome. Hosts: Nels Elde and Vincent Racaniello Guest: Mia Levine Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiEVO Levine Lab at U Penn Telomere elongation without telomerase (bioRxiv) Letters read on TWiEVO 36 Science Picks Nels - Cinema Science podcast Vincent - Mastodon bones unearthed (Instagram, Grand Rapids News) Music on TWiEVO is performed by Trampled by Turtles
2018-10-241h 15This Week in EvolutionStrawberry sex chromosomes foreverNels and Vincent reveal that female-specific DNA associated with sex in strawberries has repeatedly changed its genomic location, possibly linking new genes with sex. Hosts: Nels Elde and Vincent Racaniello Become a patron of TWiEVO Jumping sex genes in strawberries (PLoS Biol) Red Queen by Matt Ridley Image credit Letters read on TWiEVO 35 Science Picks Nels - New snailfish and Cloned crayfish Vincent - A PhD Lab Coat Ceremony Listener Picks Steve - Diversity in simple blobs Justin - On Growth and Forms by D'Arcy Wentworth Thom...
2018-09-211h 36
ImmuneImmunomimetic designer cellsCindy and Vincent describe the construction of a gene network that programs mammalian cells to detect and eliminate bacterial infections. Hosts: Vincent Racaniello and Cynthia Leifer Become a patron of Immune! Links for this episode Immunomimetic designer cells (Cell) Antimicrobial drug resistance (NIH) Image credit Letters read on Immune 11 Science Picks Cindy - No Tdap link to autism Vincent- Unpaywall Music by Steve Neal. Immune logo image by Blausen Medical. Send your immunology questions and comments to immune@microbe.tv
2018-08-181h 08This Week in EvolutionYou don’t know what you’ve got ‘til it’s PONNels and Vincent discuss how the loss of an enzyme in marine mammals millions of years ago now makes them at risk for neurotoxicity caused by human-made organophosphorous pesticides. Hosts: Nels Elde and Vincent Racaniello Become a patron of TWiEVO Ancient lossesof paraoxonase I (Science) Big Yellow Taxi (YouTube) Image credit Letters read on TWiEVO 34 Hey farmer farmer put away the chlor-pyri-fus I don’t care about spots on my apples Leave me the manatee and walruses Science Picks Nels - New dinosaur discovered in Utah Vincent ...
2018-08-161h 22This Week in EvolutionFly by virusNels and Vincent are astounded by the finding of an insect-derived virus in a fungus that manipulates the behavior of flies. Hosts: Nels Elde and Vincent Racaniello Become a patron of TWiEVO Virus in fungus in fly (bioRxiv) On a leaf, no one can hear you scream (TWiV 443) Nels gives Benzer Lecture (YouTube) Domestication of fungal fly pathogen (bioRxiv) Sequencing E. muscae genome (10X genomics) Eisen's twitter stream on new iflavirus (Twitter) Science Picks Nels - Mindsuckers; getting photos; Anand Varma photos Vincent - Happy Birthday Gregor Mendel Music on T...
2018-07-251h 20This Week in VirologyOutbreakVincent visits the Smithsonian Institution and speaks with Sabrina Sholts, Jon Epstein, and Ed Niles about the exhibit Outbreak: Epidemics in a Connected World. Host: Vincent Racaniello Guests: Sabrina Sholts, Jon Epstein, and Ed Niles Become a patron of TWiV! Links for this episode Sabrina Sholts Jonathan Epstein EcoHealth Alliance Outbreak at the Smithsonian ASM partners with Smithsonian (bLog Phase) Vincent as museum object (AMNH) Video of this episode (YouTube) Intro music is by Ronald Jenkees. Send your virology questions and comments to twiv@microbe.tv
2018-07-081h 29This Week in EvolutionNever not neutralMatt joins Nels and Vincent to discuss the neutral theory of evolution and its rejection in light of genome-scale data. Hosts: Nels Elde and Vincent Racaniello Guest: Matt Hahn Become a patron of TWiEVO Hahn Lab Molecular Population Genetics by Matt Hahn Neutral theoryin light of natural selection (Mol Biol Evol) Neutral Sequence Fallacy(Assembly of Fragments) Splendor and miseryof adaptation (BMC Biol) Image credit Letters readon TWiEVO 32 Science Picks Nels - Inaugural Transposon Day Vincent - How many human genes? Listener Pick Anne- Plants r...
2018-06-201h 19This Week in VirologyEbola Makona is the opposite of hakuna matataVincent, Kathy, and Alan review the ongoing outbreak of Ebola virus in the Democratic Republic of the Congo, and the finding that mutations identified in the 2015 West African epidemic do not alter pathogenesis in animals. Hosts: Vincent Racaniello, Alan Dove, and Kathy Spindler Become a patron of TWiV! Links for this episode ASM Microbe 2018 Support Viruses & Cells Gordon Conference Faculty positions at Icahn School of Medicine International dsRNA Virus Symposium New Ebola virus outbreakin DRC (WHO) Ebola virus case in urban area of DRC(WHO) Ebola virus outbreak not PHEIC(WHO) Ebola virus...
2018-05-201h 12This Week in EvolutionVirus archaeology, or when the human genome is the junkNels and Vincent present ancient hepatitis B virus genome sequences from Bronze Age to Medieval period human remains. Hosts: Nels Elde and Vincent Racaniello Become a patron of TWiEVO Ancient hepatitis B virus genomes(Nature) Even more ancient HBV genomes(bioRxiv) Image credit Letters readon TWiEVO 31 Science Picks Nels - Sampling whale breathwith drones (Preprint) Vincent - Verge Science Music on TWiEVO is performed by Trampled by Turtles Send your evolution questions and comments to twievo@microbe.tv
2018-05-201h 21This Week in EvolutionDriving Miss Maize-yNels and Vincent reveal how a motor protein in corn causes preferential transmission of chromosomes to egg cells, leading to non-Mendelian inheritance. Hosts: Nels Elde and Vincent Racaniello Become a patron of TWiEVO Molecular Evolution and the Cellmeeting Selfishcorn chromosomes (Cell) Dawe Lab- neocentromeres and meiotic drive Image credit Letters readon TWiEVO 30 Science Picks Nels - Craypot stinkhorn mushroom (Colus pusilus) Vincent -Doubts raised over plan to release herpesvirus to wipe out carp Music on TWiEVO is performed by Trampled by Turtles Send your evolution questions and commen...
2018-04-211h 15This Week in EvolutionEvolution on the wingNels and Vincent discuss the evolution of blood feeding to nonbiting in a mosquito, and evolution of bacterial virulence in the house finch caused by incomplete host immunity. Hosts: Nels Elde and Vincent Racaniello Become a patron of TWiEVO Molecular Evolution and the Cell meeting Mosquito evolution from blood feeding to nonbiting (PNAS) Mosquito blood feeding is not a free lunch (virology blog) Incomplete immunity and evolution of virulence (Science) Image credit Letters read on TWiEVO 29 Science Picks Nels - IDEA and Impossible Foods Vincent - it is NOT junk Mu...
2018-03-211h 42This Week in VirologyEvery infection is unhappy in its own wayVincent and the Virals review undermining of antiviral effectiveness by genital inflammation, and heterogeneity of influenza virus infection in single cells. Hosts: Vincent Racaniello, Alan Dove, and Kathy Spindler Become a patron of TWiV! Links for this episode USA Science and Engineering Festival Genital inflammation and antiviral effectiveness (Nat Med) Single cell infection heterogeneity (eLife) Single-cell poliovirus infection (Virology) Image credit Letters read on TWiV 483 Weekly Science Picks Kathy - Dance Dance Rich - Snopes Alan - Next Generation Science Standards Vincent - TWiEVO 28: Genetics of skin pig...
2018-03-041h 41This Week in EvolutionGenetics of skin pigmentation in AfricaSarah Tishkoff joins Nels and Vincent to explain work from her laboratory on the genetic basis of skin pigmentation in Africans. Hosts: Nels Elde and Vincent Racaniello Guest: Sarah Tishkoff Become a patron of TWiEVO Molecular Evolution and the Cell meeting Sarah AMA on Reddit Genetics of African skin pigmentation (Science) Image credit Science Picks Nels - In Defense of Plants (Shrew Loo) Vincent - Contribution of NIH funding to new drug approvals Music on TWiEVO is performed by Trampled by Turtles Send your evolution...
2018-02-281h 19This Week in EvolutionColdevoTaking a cue from the recent frigid weather, Nels and Vincent explore how modifications of a neuronal cold-sensing channel regulate diminished cold sensitivity in hibernating mammals. Hosts: Nels Elde and Vincent Racaniello Become a patron of TWiEVO Why ground squirrels and hamsters don't mind the cold (Cell Rep) Image credit Letters read on TWiEVO 27 Science Picks Nels - Undergrad podcasters from Stonehill College Vincent - Viruses at Target Music on TWiEVO is performed by Trampled by Turtles Send your evolution questions and comments to twievo@microbe.tv
2018-01-131h 18ImmuneTwo epitopes, four serotypes, and a partridge in a pear treeCindy, Steph, and Vincent discuss recent problems with dengue virus vaccine, and a bi-specific monoclonal antibody against Zika virus. Hosts: Vincent Racaniello, Stephanie Langel, and Cynthia Leifer Become a patron of Immune! Links for this episode Model for dengue ADE (Scitable) Dengue ADE in humans (Science) Dengvaxia discussion (TWiV 471) Bi-specific antibody to Zika virus (Cell) Building Zika Virus Letters read on Immune #3 Weekly Science Picks Cindy - Questions answered about starving polar bear video Steph - Deep Work by Cal Newport and Grad Student Tax Vincent - Making...
2017-12-161h 19This Week in EvolutionMy Scientist VinnyVinny Lynch joins Nels and Vincent to discuss how a zombie gene in elephants protects these large, long lived animals from cancer. Hosts: Nels Elde and Vincent Racaniello Guest: Vinny Lynch Become a patron of TWiEVO Lynch Lab Elephant zombie LIF gene induces apoptosis (bioRxiv) Image credit Science Picks Nels - Animalism Vincent - Voyager I fires up thrusters after 37 years Vinny - Rollin' Wild Music on TWiEVO is performed by Trampled by Turtles Send your evolution questions and comments to twievo@mic...
2017-12-071h 13ImmuneLymphocytes after darkCindy, Steph, and Vincent reveal that lymphocyte trafficking through lymph nodes and lymph are circadian - it is dependent on the time of day. Hosts: Vincent Racaniello, Stephanie Langel, and Cynthia Leifer Become a patron of Immune! Links for this episode Circadian clocks control lymphocyte trafficking (Immunity) Lymph node image credit Letters read on Immune #2 Weekly Science Picks Cindy - Men ask more questions than women at a scientific conference (PLoS One) Steph - House just voted to bankrupt graduate students Vincent - Trump's Legacy: Damaged Brains ...
2017-11-251h 26This Week in EvolutionPigeons show the wayNels and Vincent discuss a genomic analysis of the passenger pigeon, which shows that species with large and stable populations may be at risk of extinction after a sudden environmental change. Hosts: Nels Elde and Vincent Racaniello Become a patron of TWiEVO Passenger pigeon genomic diversity (Science) Image credit Letters read on TWiEVO 25 Science Picks Nels - Video of nematophagous fungi Vincent - How should novelty be valued in science? John - Evo-Devo (Despacito Biology Parody) Melanie - What's in John's Freezer Music on TWiEVO is performed...
2017-11-231h 38ImmuneSome like it hotCindy, Steph, and Vincent launch a new podcast, Immune, and reveal how warm temperature protects against atherosclerosis by regulating monocyte migration into the blood. Hosts: Vincent Racaniello, Stephanie Langel, and Cynthia Leifer Become a patron of Immune! Links for this episode Leifer Lab at Cornell Stephanie Langel Thermoneutrality suppresses monocyte egress from bone marrow (Circ Res) Fever regulates immunity (Nat Rev Immunol) Macrophage image by Blausen Medical Weekly Science Picks Cindy - FDA approves second CAR T cell therapy Steph - Gammaherpesvirus protects against asthma Vincent - Truth...
2017-10-311h 05This Week in EvolutionGood viruses visiting bad neighborhoodsMarco Vignuzzi joins Nels and Vincent to discuss recent work from his laboratory on redirecting RNA virus evolution in sequence space. Hosts: Nels Elde and Vincent Racaniello Guest: Marco Vignuzzi Become a patron of TWiEVO Vignuzzi Laboratory Redirecting evolution of RNA viruses in sequence space (Nat Micro) Is quasispecies concept relevant to RNA viruses? (J Virol) This episode is brought to you by Blue Apron. Blue Apron is the #1 fresh ingredient and recipe delivery service in the country. Get $30 off your first order and free shipping by going to blueapron.com/twie.
2017-10-261h 33This Week in EvolutionThe Alus are going to be alrightNels and Vincent reveal how the protein DHX9 suppresses RNA processing defects caused by invasion of the Alu retroelement into the human genome. Hosts: Nels Elde and Vincent Racaniello Become a patron of TWiEVO DHX9 suppresses Alu defects (Nature) Asifa Akhtar on The Latest Thinking This episode is brought to you by Blue Apron. Blue Apron is the #1 fresh ingredient and recipe delivery service in the country. See what’s on the menu this week and get your first 3 meals free with your first purchase – WITH FREE SHIPPING – by going to blueapron.com/twie.
2017-09-201h 14This Week in EvolutionE pluribus cerevisiaeMaitreya Dunham joins Nels and Vincent to explain how her laboratory uses experimental evolution to study yeast flocculation, the community-building cell aggregation trait. Hosts: Nels Elde and Vincent Racaniello Guest: Maitreya Dunham Become a patron of TWiEVO Dunham Laboratory Adaptive Routes to Cell Aggregation in Yeast (Genetics) Making the best of a sticky situation (SGD) Yeast Genetics and Genomic Course (Cold Spring Harbor) Genetic basis of biofilm formation (Beacon) 2017 CSH Plate Race (YouTube) Image credit This episode is brought to you by Blue Apron. Blue Apron is the #1 fresh ingredient and recipe...
2017-08-301h 21This Week in EvolutionTWiEVO 21: A virus with a green thumbRich Condit joins Nels and Vincent to explain how a vaccinia virus protein customizes ribosomes to favor the translation of viral mRNAs with a stretch of A residues in the 5'-untranslated region. Hosts: Nels Elde and Vincent Racaniello Become a patron of TWiEVO Rich Condit with Harry Noller (scroll down) Trans-Kingdom mimicry? (Nature) More on RACK1 (Nat Struct Mol Biol) Image credit Letters read on TWiEVO 21 This episode is brought to you by Blue Apron. Blue Apron is the #1 fresh ingredient and recipe delivery service in the country. See what’s on the me...
2017-07-131h 45This Week in EvolutionTWiEVO 20: In the company of cnidariansNels and Vincent explore the role of TSR proteins during colonization of cnidarians by dinoflagellates. Hosts: Nels Elde and Vincent Racaniello Become a patron of TWiEVO TSR domain proteins in cnidarian-dinoflagellate symbiosis A. elegantissima image credit Letters read on TWiEVO 20 Science Picks Nels - CRISPR 5 ways Vincent - The Vital Question by Nick Lane Music on TWiEVO is performed by Trampled by Turtles Send your evolution questions and comments to twievo@microbe.tv
2017-06-201h 42This Week in EvolutionTWiEVO 19: The beauty of the storyJonathan Weiner, author of the Pulitzer Prize-winning Beak of the Finch, joins Nels and Vincent to talk about his career and his writing. Hosts: Nels Elde and Vincent Racaniello Guest: Jonathan Weiner Become a patron of TWiEVO Jonathan's Columbia University page Jonathan's author page Science Picks Nels - The Gap by Ira Glass Vincent - EPA removes climate science site Music on TWiEVO is performed by Trampled by Turtles Send your evolution questions and comments to twievo@microbe.tv
2017-05-241h 24This Week in EvolutionTWiEVO 18: Raiders of the lost orcoHosts: Nels Elde and Vincent Racaniello Guests: Ni-Chen 'Sylvia' Chang, Waring 'Buck' Trible, and Sean K. McKenzie Buck and Sean join Vincent in New York, while Sylvia is with Nels in Salt Lake City to discuss the first mutant ant ever made: disruption of orco, a gene required for function of odorant receptors, show defects in social behavior and fitness. Become a patron of TWiEVO First ant mutants link odorant receptors and social behavior (bioRxiv) Kronauer Lab This episode is brought to you by Blue Apron. Blue Apron is the #1...
2017-04-101h 32This Week in VirologyTWiV Special: Vincent Munster on MERS-coronavirus and Ebolavirus Host: Vincent Racaniello Guest: Vincent Munster At the Rocky Mountain Laboratory in Hamilton, Montana, Vincent speaks with Vincent Munster about the work of his laboratory on MERS-coronavirus and Ebolaviruses. Become a patron of TWiV! Links for this episode Rocky Mountain Laboratory Munster Laboratory Small town, big science (TWiM 140) Image credit Send your virology questions and comments to twiv@microbe.tv
2017-02-0856 minThis Week in VirologyTWiV 401: Vector victoriousHosts: Vincent Racaniello, Dickson Despommier, Alan Dove, and Kathy Spindler Zika virus spreads in the USA, a Zika virus DNA vaccine goes into phase I trials, and how mosquito bites enhance virus replication and disease, from the friendly TWiFolk Vincent, Dickson, Alan, and Kathy. Become a patron of TWiV! Links for this episode Beverly Griffin, 86 (1 2 3) Zika virus in the US (CDC) Zika virus spreading in Miami (CDC) Zika virus in Florida (NY Times) NIH begins phase I trial of Zika virus DNA vaccine (NIAID) Mosquito salive enhances West Nile replication in mice (J Virol) Mosqui...
2016-08-071h 58This Week in VirologyTWiV 395: The cancer thiefHosts: Vincent Racaniello, Rich Condit, and Kathy Spindler Guest: Stephen J. Russell From ASV 2016 at Virginia Tech, Vincent, Rich and Kathy speak with Stephen Russell about his career and his work on oncolytic virotherapy - using viruses to treat cancers. Become a patron of TWiV! Links for this episode Hokies go viral (TWiV 285) MV NIS de Myelo (TWiV 298) Remission of disseminated myeloma after MV treatment (Mayo Clin Proc) miRNA detargeting (J Virol) Video of this episode at YouTube This episode is sponsored by CuriosityStream. Get two months free when you ...
2016-06-261h 00This Week in VirologyTWiV 394: Cards in a handHosts: Vincent Racaniello and Alan Dove Guest: Erica Ollmann Saphire Vincent and Alan speak with Erica about her career and her work on understanding the functions of proteins of Ebolaviruses, Marburg virus, and other hemorrhagic fever viruses, at ASM Microbe 2016 in Boston, MA. Become a patron of TWiV! Links for this episode Structure of antibodies bound to Ebola virus glycoprotein (PNAS) Structure of cross-reactive filovirus antibody (Cell) Multiple functions of Ebola virus VP40 protein (Cell) View video of this episode on YouTube Letters read on TWiV 394 This episode is spo...
2016-06-191h 29This Week in VirologyTWiV 388: What could possibly go wrong?Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, and Kathy Spindler Preprint servers, the structure of an antibody bound to Zika virus, blocking Zika virus replication in mosquitoes with Wolbachia, and killing carp in Australia with a herpesvirus are topics of this episode hosted by Vincent, Dickson, Alan, and Kathy. Links for this episode biorXiv preprint server Please review Vaccines and Your Child Structure of antibody bound to Zika virus E protein (Cell Host Microbe) Wolbachia blocks Zika virus in mosquitoes (Cell Host Microbe) Zimmer on Wolbachia and Zika virus (NY Times) Fauci on Zika v...
2016-05-081h 40This Week in VirologyTWiV 372: Latent viral tendenciesHosts: Vincent Racaniello, Alan Dove, Rich Condit, and Kathy Spindler
The TWiV-osphere introduces influenza D virus, virus-like particles encoded in the wasp genome which protect its eggs from caterpillar immunity, and a cytomegalovirus protein counters a host restriction protein that prevents establishment of latency.
Links for this episode
Ebolavirus update (ProMedMail)
Influenza D virus (mBio)
Vincent's influenza C virus paper (J Virol)
Virus-like particles protect wasp eggs (Sci Adv)
CMV protein foils cell defense against latency (Sci Adv)
Image credit: Mark
Letters read on TWiV 372
This episode is sponsored by ASM Grant Writing Webinar...
2016-01-172h 04This Week in VirologyTWiV 365: Blood, feuds, and a foodborne diseaseHosts: Vincent Racaniello, Alan Dove, and Kathy Spindler
For a TWiV Thanksgiving, Vincent, Alan, and Kathy trace the feud over genome editing, a new virus discovered in human blood, and the origins of hepatitis A virus.
Links for this episode
Battle over genome editing (Wired) 10:05
First description of CRISPR in E. coli (J Bacteriol) 14:00
Cas genes identified (Mol Micro) 14:20
CRISPR-Cas provides immunity to bacterial viruses (Science) 15:35
Cas9-crRNA complex mediates DNA cleavage (PNAS) 16:55
Dual RNA-guided DNA endonuclease in bacterial immunity (Science) 17:50
Genome engineering using CRISPR/Cas (Science) 18:50
Cpf1 endonuclease (Cell) 23:10
Classification of CRISPR/Cas systems (Nat Rev Mic...
2015-11-291h 49This Week in VirologyTWiV 364: It's not SARS 2.0Hosts: Vincent Racaniello, Rich Condit, and Kathy Spindler
Guests: Ralph Baric and Vineet Menachery
Vincent, Rich, and Kathy speak with Ralph and Vineet about their research on the potential of SARS-like bat coronaviruses to infect human cells and cause disease in mice.
Links for this episode
Zoonotic potential of SARS-like bat viruses (Nature)
SARS-CoV susceptibility loci via collaborative cross (PLoS Genetics) 47:00, 57:25
Ebright and Wain-Hobson quotes (Nature) 1:17:20
Misleading press release (UNC) 1:24:45
Super powerful SARS 2.0 (not!) (Motherboard)
SARS-like bat virus can jump without mutating (not!) (Daily Mail) 1:26:30
Photo credit
Letters read on TWiV 364 1:47:40
Thi...
2015-11-222h 10This Week in VirologyTWiV 360: From Southeastern MichiganHosts: Vincent Racaniello and Kathy Spindler
Guests: Michael Imperiale, Adam Lauring, and Akira Ohno
Vincent visits the University of Michigan where he and Kathy speak with Michael, Adam, and Akira about polyomaviruses, virus evolution, and virus assembly, on the occasion of naming the department of Microbiology & Immunology a Milestones in Microbiology site.
Links for this episode
World Polio Day 3:20
Mole Day 5:25
The rat virus (J Inf Dis) 20:00
Polyomavirus miRNAs (Curr Op Virol) 39:30
Costs of GOF pause (mBio) 45:00
Lethal mutagenesis of influenza virus (J Virol) 1:03:35
Mutational robustness in RNA virus evolution (Nat Rev Micro) 52:00
Me...
2015-10-251h 35This Week in VirologyTWiV 349: One ring to vaccinate them allHosts: Vincent Racaniello, Alan Dove, and Rich Condit
Vincent, Alan and Rich explain how to make a functional ribosome with tethered subunits, and review the results of a phase III VSV-vectored Ebolavirus vaccine trial in Guinea.
Links for this episode
Social media specialist position at ASM
WHO dismisses Catholic church on vaccine safety
U of T Dean resigns over anti-vaccine course (Tor Star)
Vaccine Adverse Event Reporting System (VAERS)
Countering anti-vaccination attitudes (PNAS)
Designer ribosome (Nature)
rVSV-EBOV preliminary report (NEJM)
rVSV-EBOV phase III interim report (pdf, Lancet)
World on verge of Ebolavirus vaccine (WHO)
Ebol...
2015-08-091h 50This Week in VirologyTWiV 348: Chicken shiftHosts: Vincent Racaniello and Rich Condit
Vincent and Rich discuss fruit fly viruses, one year without polio in Nigeria, and a permissive Marek's disease viral vaccine that allows transmission of virulent viruses.
Links for this episode
Virology tenure-track position at NCI (pdf)
ASM Agar Art Contest
Nigeria on brink of polio eradication (Nature)
Dengue in Africa (Tyler Sharp)
Permissive vaccines and virulence (PLoS Biol)
Marek's disease vaccines and virulence (Ed Yong)
Image credit
Letters read on TWiV 348
This episode is sponsored by ASM GAP
Weekly Science Picks
Rich - Swan-Ganz ca...
2015-08-021h 45This Week in VirologyTWiV 347: Rose rosette and squirrel rouletteHosts: Vincent Racaniello, Alan Dove, and Rich Condit
Vincent, Alan, and Rich discuss the virus behind rose rosette disease, and fatal human encephalitis caused by a variegated squirrel bornavirus.
Links for this episode
Virology tenure-track position at NIH (pdf) 7:00
Voinnet investigation is a Swiss Federal secret (twitter) 12:25
Rose rosette disease in Ft. Worth (Star Telegram) 29:35
Rose rosette virus discovered (J Gen Virol) 34:25
Emeravirus (ViralZone) 33:55
Eriophyid mites (MI Botanical Garden) 32:40
Mite vector of rose rosette disease (U Florida) 34:55
Image credit
Squirrel bornavirus associated with human encephalitis (NEJM) 38:40
Poll: How do you consume podcasts? 1:21:40
Letters read on TWiV 347 8:10...
2015-07-261h 27This Week in VirologyTWiV 346: A double helical careerHosts: Vincent Racaniello, Rich Condit, and Kathy Spindler
Guest: Joan Steitz
This episode was recorded at the 34th Annual Meeting of the American Society for Virology, where Vincent, Rich, and Kathy spoke with Joan Steitz, a tireless promoter of women in science and one of the greatest scientists of our generation.
Links for this episode
ASV annual meeting, Western University
Steitz Laboratory at Yale University
Steitz Laboratory on Twitter
Panoramic photo of ASV TWiV by Matt Evans
Photos of ASV2015 (Facebook)
Video of this episode - view at YouTube
Weekly Science Picks
2015-07-191h 01This Week in VirologyTWiV 338: Coyotes have sushiHosts: Vincent Racaniello and Kathy Spindler
Guest: Laura Newcomb
Vincent and Kathy visit Laura Newcomb at California State University San Bernardino, where they talk about Laura's viral tatoos, and a protein that protects the mosquito brain from lethal flavivirus infection.
Links for this episode
Neuron-specific mosquito antiviral mechanism (PLoS Path)
Letters read on TWiV 338
Photos of our visit
Video of this episode - view at YouTube
Weekly Science Picks
Laura - NP siRNA inhibits different influenza viruses (Antiviral Res)Kathy - Time-lapse miningVincent - Does the public trust sc...
2015-05-2459 minThis Week in VirologyTWiV 316: The enemy of my enemy is not my friendHosts: Vincent Racaniello, Alan Dove, Rich Condit, and Kathy Spindler
Vincent, Alan, Rich and Kathy discuss how interleukin 10 modulation of Th17 helper cells contribute to alphavirus pathogenesis.
Links for this episode
IL10 modulation of Th17 cells during alphavirus pathogenesis (PNAS)
Th17 cells involved in influenza mediated gut injury (J Exp Med)
Helper T cells
2014-15 flu season (CDC)
Key facts about flu & flu vaccine (CDC)
Does the flu vaccine work? (Turbid plaque)
Effectiveness of flu vaccine (virology blog)
Image credit
Letters read on TWiV 316
Weekly Science Picks
Alan - It came from the pond
2014-12-211h 31This Week in VirologyTWiV 315: Must be something in the waterHosts: Vincent Racaniello, Alan Dove, Rich Condit, and Kathy Spindler
Vincent, Alan, Rich and Kathy association of a virus with sea star melting disease, and the finding of a phycodnavirus in the oropharynx of humans with altered cognitive functions.
Links for this episode
National Influenza Immunization Week (CDC)
Densovirus associated with sea star wasting disease (PNAS)
A virus that melts sea stars (virology blog)
Chlorovirus in human oropharynx (PNAS)
Algal virus in humans (virology blog)
Image credit
Letters read on TWiV 315
Weekly Science Picks
Alan - ReelLife Science 2014 WinnersRich - The Martian by...
2014-12-131h 27This Week in VirologyTWiV 313: With viruses like these, who needs enemas?Hosts: Vincent Racaniello, Alan Dove, and Rich Condit
Vincent, Alan, and Rich discuss how norovirus, an enteric virus, can replace the functions of the gut microbiome.
Links for this episode
Ebola virus update (WHO)
Norovirus can replace functions of gut microbiome (Nature)
Post-vaccinal distemper encephalitis (N Z Vet J)
Novel sea otter poxvirus (J Wildl Dis)
Poliovirus escapes antibodies (virology blog)
CDC whistleblower saga (Sci Based Med)
Snopes on CDC whistleblower
Image credit
Letters read on TWiV 313
Video of this episode - view at YouTube
Weekly Science Picks
Alan - RetrocomputingRich - Where is...
2014-11-301h 38This Week in VirologyTWiV 305: Rhymes with shinolaHosts: Vincent Racaniello, Alan Dove, and Kathy Spindler
Vincent, Alan, and Kathy continue their coverage of the Ebola virus outbreak in West Africa, with a discussion of case fatality ratio, reproductive index, a conspiracy theory, and spread of the virus to the United States.
This episode of TWiV is brought to you by the Department of Microbiology at Icahn School of Medicine at Mount Sinai. Composed of over 20 virology labs, all centralized in one building in the heart of New York City, this department is a perfect fit for anyone with an interest in pursuing virus...
2014-10-051h 32This Week in VirologyTWiV 300: So happy togetherHosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Kathy Spindler
Recording together for the first time, the TWiV team celebrates their 300th recording at the American Society for Microbiology headquarters in Washington, DC, where Vincent speaks with Dickson, Alan, Rich, and Kathy about their careers in science.
Links for this episode
So Happy Together (The Turtles)
Viral Hemorrhagic Fever Consortium
Support Kenema VHFC program
Letters read on TWiV 298
Video of this episode - view at YouTube
Weekly Science Picks
Alan - The Internet's Original SinDickson - PlacidcoyoteRich - S...
2014-08-311h 32This Week in VirologyTWiV 291: Ft. Collins abuzz with virologistsHosts: Vincent Racaniello, Rich Condit, and Kathy Spindler
Guests: Clodagh O'Shea and Ron Fouchier
Vincent, Rich, and Kathy and their guests Clodagh and Ron recorded this episode at the 33rd annual meeting of the American Society for Virology at Colorado State University in Ft. Collins, Colorado.
Links for this episode
Viral polymer that inactivates tumor suppressors (Cell)
Mutations driving airborne transmission of influenza H5N1 virus (Cell)
Transmission of influenza H7N1 virus in ferrets (J Virol)
Ron Fouchier on TWiV #177
Photo credit: Matt Evans
Thanks to David Quammen for the title
Video of this e...
2014-06-291h 06
Urban AgricultureUrban Agriculture 5: From the classroom to the tableHosts: Dickson Despommier and Vincent Racaniello
Dickson and Vincent discuss how the vertical farm concept was developed and where it stands today.
Links for this episode
Vertical farming (Wikipedia)
Dickson on Colbert Report
South Korea researches vertical farming
Cary Fowler (Wikipedia)
Commercial vertical farms
Vertical farm in Scranton, PA
Omega Garden hydroponics
A bright future (HuffPo)
Tower Garden aeroponics
Letters read on UrbAg 5
Vincent's pick
Big Ideas (YouTube)
Send your questions and comments to urbanag@urbanag.ws
2014-06-141h 47This Week in VirologyTWiV 286: Boston TWiV partyHosts: Vincent Racaniello and Alan Dove
Guests: Julie Pfeiffer and Paul Duprex
Vincent and Alan meet up with Julie and Paul at the General Meeting of the American Society for Microbiology in Boston, to talk about their work on the pathogenesis of poliovirus and measles virus.
Links for this episode
Threading the NEIDL (YouTube)
Transmission of measles virus from macaques (J Gen Virol)
Tropism of green measles virus in macaques (J Virol)
Intestinal microbiota promote enteric virus replication (Science)
Bacterial LPS enhances poliovirus stability (Cell Host Micr)
Video of this episode - view below or...
2014-05-261h 34This Week in VirologyTWiV 279: The missing LNCHosts: Vincent Racaniello, Alan Dove, and Kathy Spindler
Vincent, Alan, and Kathy reveal how a retrovirus in the human genome keeps embryonic stem cells in a pluripotent state, from where they can differentiate into all cells of the body.
Links for this episode
Retrovirus needed for stem cell identity (Nat Struc Mol Biol)
HERV-H is a marker for pluripotency (Retrovirology)
Letters read on TWiV 279
Weekly Science Picks
Alan - HeathkitVincent - How to think about autism risk and Autism prevalenceKathy - Distortions
Listener Pick of the Week...
2014-04-061h 29This Week in VirologyTWiV 278: Flushing HIV down the zincHosts: Vincent Racaniello, Dickson Despommier, Alan Dove, and Kathy Spindler
Vincent, Dickson, Alan, and Kathy discuss disruption of the ccr5 gene in lymphocytes of patients infected with HIV-1.
Links for this episode
Gene editing of ccr5 in AIDS patients (NEJM)
HIV gets the zinc finger (TWiV 144)
Genome engineering with zinc finger nucleases (Genetics)
Photo credit: Watty's Wall Stuff
Mice lie, monkeys exaggerate t-shirt design (thanks, Christophe)
Letters read on TWiV 278
Weekly Science Picks
Alan - Digital scale model of solar systemDickson - Font of knowledgeVincent - Measles outbreaks trends, and...
2014-03-301h 42This Week in VirologyTWiV 276: Ramblers go viralHost: Vincent Racaniello
Guests: Susan Baker and Thomas Gallagher
Vincent meets up with Susan Baker and Tom Gallagher at Loyola University to talk about their work on coronaviruses.
Links for this episode
Papain-like viral proteases (Virus Res)
MERS-CoV papain-like protease (Virology)
Mouse model for MERS-CoV (PNAS)
Receptor and MERS-CoV infection (J Virol)
Letters read on TWiV 276
Video of this episode - view at YouTube
Weekly Science Picks
Vincent - First demonstration of Macintosh, 1984
Listener Pick of the Week
Lance - The Signal and the Noise by Nate S...
2014-03-161h 09
Dr. Kiki's Science Hour (Audio)Infecting The Brick House - We talk about viruses with Dr. Vincent Racaniello from This Week in Virology.
We talk about viruses with Dr. Vincent Racaniello from This Week in Virology.
Host: Dr. Kiki Sanford
Guest: Vincent Racaniello, Ph.D
Download or subscribe to this show at https://twit.tv/kiki.
We invite you to read, add to, and amend our show notes.
Thanks to CacheFly for the bandwidth for this show.
2011-07-291h 03
Dr. Kiki's Science Hour (Video)Infecting The Brick House - We talk about viruses with Dr. Vincent Racaniello from This Week in Virology.
We talk about viruses with Dr. Vincent Racaniello from This Week in Virology.
Host: Dr. Kiki Sanford
Guest: Vincent Racaniello, Ph.D
Download or subscribe to this show at https://twit.tv/kiki.
We invite you to read, add to, and amend our show notes.
Thanks to CacheFly for the bandwidth for this show.
2011-07-291h 03
This Week in ParasitismTWiP #6 - Tapeworms, the long and short of itVincent and Dick talk about the anatomy and life cycle of beef and pork tapeworms, and why House was wrong about neurocysticercosis.
Host links: Vincent Racaniello and Dickson Despommier
Links for this episode:
Taenia saginata life cycle (jpg)
Taenia saginata adult (jpg)
Taenia saginata scolex (jpg)
Taenia saginata gravid proglottid (jpg)
Taenia solium life cycle (jpg)
Taenia solium adult (jpg)
Taenia solium scolex (jpg)
Facial cancer in Tasmanian devils (thanks PhogDog!)
Science Picks
Dickson Peace through vaccine diplomacy by Peter HotezVincent Parasite Rex by Carl Zimmer
2010-03-251h 41
This Week in ParasitismTWiP #4 - Trichinella life cycleVincent and Dick trace the life cycle of Trichinella spiralis in an infected host.
Host links: Vincent Racaniello and Dickson Despommier
Links for this episode:
Trichinella life cycle (jpg)
Newborn larva entering muscle cell (jpg)
Adult T. spiralis in columnar epithelial cell (jpg)
Adult female T. spiralis (jpg)
Infective first stage T. spiralis larva in Nurse cell in muscle tissue (jpg)
Adult female T. spiralis with fully formed larvae in uterus (jpg)
Adult male T. spiralis with claspers on tail (jpg)
Clinical correlations in trichinosis (jpg)
Letters read on TWiP #4
Weekly Science Picks
...
2010-01-301h 22
This Week in ParasitismTWiP #1 - Introduction to parasitismVincent and Dick provide an overview of parasites and parasitism.
Host links: Vincent Racaniello and Dickson Despommier
Weekly Science Picks
Dick The Black Cloud by Fred HoyleVincent Parasitic Diseases by Despommier et al.
2009-11-1357 min