Shows
The Synthesis of Wellness®166. Increased Intestinal Permeability & Hypothalamic-Pituitary-Adrenal (HPA) Axis Dysfunction | Cortisol & MoreIn this episode, we detail the bidirectional relationship between the HPA axis and the intestinal barrier, illustrating how HPA axis dysfunction and cortisol dysregulation can impact intestinal permeability. We further discuss how intestinal dysbiosis can contribute to HPA axis overstimulation. Lastly, we detail some of the roles of short-chain fatty acids (SCFAs) and secretory IgA (sIgA) in this bidirectional relationship.Topics: 1. Overview of the HPA Axis and Gut Bidirectional Relationship- Chronic HPA activation, intestinal permeability, mucosal immunity, and microbiome composition. 2. Components and Function of the HP...2025-02-2119 min
CONKERS' CORNERTWINPETESINVESTING PODCAST 142: How to find winning recovery stocks, Pearson, Nick Train, CRH, WISE, St James's Place, Bitcoin, UnitedHealthcare, Alfa Financial Software, Bytes Technology, Brooks Macdonald, Ashtead, THG BUR LIT AVCT BOOM MKA GKP InvestingThe topics, stocks and shares mentions / discussed include:
How to find winning recovery stocks,
UnitedHealthcare / UNH
Pearson / PSON / Nick Train
CRH
WISE
St James's Place / STJ
Alfa Financial Software Holdings / ALFA
Bytes Technology / BYIT
Brooks Macdonald / BRK
Ashtead / AHT
Bitcoin / BTC / Crypto / FOMO
THG
Artificial Intelligence / Ai
Avacta / AVCT
The November TwinPetesInvesting Challenge winner
Burford Capital / BUR
Litigation Capital / LIT
Mkango Resources / MKA
Gulf Keystone Petroleum / GKP
AudioBoom / BOOM
Charity Fundraising for CentrePoint
Investing
Trading & more
...2024-12-131h 22
Decarb ConnectCRH Ventures’ drive to support First Of A Kind plants and tech commercializationJoin Eduardo Gomez Mendoza, SVP and Head of CRH Ventures as he shares his perspective on how we can scale the most-needed hardware tech to deliver industrial decarbonisation. Welcome to this special edition of the Decarb Connect podcast featuring one of the 50+ speakers at Decarb Techinvest. We will be exploring, through a few conversations, how we scale up (beyond series B) and truly commercialise the hardware tech that transform our most essential, but co2 intensive, sectors. Eduardo Gomez Mendoza, SVP and Head of CRH Ventures, took on the mission to launch and...2024-08-2331 min
Blood PodcastClinical impact of CRh in AML; thrombosis features in a real-life PNH cohort; and restriction of SOX11 expression to EBV-negative Burkitt lymphomasIn this week's episode we'll learn about the clinical benefit of complete remission with partial hematological recovery, or CRh, in patients with Acute Myeloid Leukemia (AML) treated with molecularly targeted drugs. Then we'll hear about a large cohort of patients with PNH were studied to detail PNH-related thrombotic events, unravel determinants of thrombosis, and evaluate anti-coagulation strategies. Finally, we'll see how new research shows that SOX11 expression is restricted to EBV-negative Burkitt lymphoma, and is associated with a specific genetic landscape. Featured Articles:Complete Remission with Partial Hematological Recovery as a Palliative Endpoint for Treatment of A...2024-07-1119 min
Let’s Talk Virtual CareS1E8: My VA Images technology features and expansion / A Dynamic Conversation with VISN 22 Clinical Resource Hub (CRH) Primary Care TeamDr. Carter discusses My VA Images technology features and expansion with Dr. Dennis Oh, Dr. Helen Hoenig, and Dr. Desiree Oliveros.Dr. Carter has a Dynamic Conversation with VISN 22 Clinical Resource Hub (CRH) Primary Care TeamClosed Caption Transcript is available at: https://www.sharedfedtraining.org/Podcasts/LTVC_S1EP8.pdf ===============================2024-05-2222 min
The Renatus Podcast“Business is my hobby” - with Richie Boucher, Chairman of CRH plcRichie Boucher, Chairman of CRH plc In this episode of the Renatus Podcast, Greg Dilger talks to Richie Boucher, Chairman of CRH, a global leader in the provision of building materials solutions that build, connect and improve our world. Employing nearly 80,000 people at over 3000 locations in 29 countries, CRH’s scale is nothing less than staggering. Richie shares his insights into why CRH continues to thrive on a global stage while also revealing what makes him tick personally. He talks frankly and passionately about culture, people, strategy and more. Richie also tells us about his ot...2024-03-0755 min
Inflamed in the BrainBite Back at Stress: Your 9-Nutrient Toolkit for Navigating Stressful TimesSend us a textLinks mentioned in Episodewww.betterwithcarbo.com/2 - The Smart Approach: 5 Questions to ask yourself Before Trying SupplementsStress, Neurotransmitters, and Inflammation:Overview of the relationship between stress, neurotransmitters (adrenaline, norepinephrine, cortisol), and inflammation.Explanation of how prolonged stress leads to elevated levels of inflammatory cytokines and cortisol, potentially causing health problemsHPA Axis and Cortisol Tolerance:Detailed explanation of the Hypothalamus-Pituitary-Adrenal (HPA) axis and how chronic stress can lead to cortisol tolerance.Emphasis on the role of cortisol in...2024-01-0920 min
Animals at Home Network185: Should You Buy a Reptile From PetSmart? | Paul Barclay - AAHPaul Barclay is the owner and founder of Custom Reptile Habitats. In the episode, Paul discusses his background in the pet industry and the inspiration behind starting his own business. He talks about the lack of quality reptile enclosures and how he saw an opportunity to create something better. Paul also emphasizes the importance of big box pet stores in the industry and the need for better understanding and collaboration among different segments of the industry. He addresses the controversy surrounding the treatment of animals in breeding facilities and the importance of giving animals time to adapt to new...2024-01-062h 16The Synthesis of Wellness®89. Hacking the Cortisol Awakening Response for Increased Energy & Productivity Upon Waking Up (And Improving Sleep Quality Simultaneously)As we begin a new year, it's crucial to understand how the Cortisol Awakening Response (CAR), which is closely tied to our sleep patterns and overall well-being, can impact our ability to wake up refreshed and ready to tackle the day. We'll explore the intricate biochemical processes that govern the CAR, the factors that can lead to its dysregulation, and practical strategies to reset cortisol's diurnal rhythm for optimal energy and productivity (so you can go above and beyond with your goals in 2024).
Topics:
1. Introduction
- Importance of discussing the cortisol awakening response2024-01-0526 min
Worldwide ExchangeOpenAI Chaos, Nvidia Earnings, and Infrastructure Investments 11/21/23Chaos at OpenAI continues as investors explore legal action against the company's board due to fears over the safety of their investments. Cleo Capital's Sarah Kunst discusses. Plus, Nvidia reports earnings this afternoon, with shares near an all-time high. Decatur Capital's Degas Wright gives his expectations. And, CRH is acquiring a new portfolio of building material assets for more than $2 billion. CRH CEO Albert Manifold explains.
2023-11-2144 min
Dividend TalkEP #167 | Why Dividends are better than Income from a 9-to-5 | & What about Walgreens and PepsiCo?Welcome to Episode 167 of Dividend Talk, where we dive deep into the world of dividends, financial freedom, and stock market strategies. This week, we're exploring a fundamental question: Are dividends better than income from a job?
In the News of the Week, we discuss Microsoft's recent $69 billion Activision deal and how it overcame regulatory obstacles in Britain. Plus, we break down Walgreens' earnings report, highlighting the impact of COVID-19 on their financial performance.
Our Main Topic explores the benefits of dividend income versus traditional job income. We discuss how dividends can lead to less stress...2023-10-141h 06
FundCalibre - Investing on the go278. Competitive advantage and the power of a strong brandDavid Dudding, manager of the CT Global Focus fund, and newly appointed co-manager Alex Lee, share the fund’s investment philosophy of focusing on company-specific factors, competitive advantages, and long-term growth potential. We also consider global economic trends and thematic investment opportunities such as decarbonisation and energy efficiency. David and Alex also discuss the fund’s holdings in Apple, Pepsi, CRH, and current opportunities in both Japan and emerging markets. What’s covered in this episode: Current sentiment in the global economy, region by regionConcerns about government stimulus in ChinaTrends in machinery and industrialsWhy semicond...2023-09-2824 min
Collaborative Resource Hub: Wellness in Rock and RollMy Brutal Truth | The Delay Dying Blog: Podcast Edition | The Reality Of Running A Wellness BusinessThis is The Delay Dying Blog: Podcast Edition. All essays are written by Amy McBride. Only select essays appear on the podcast. To check out the rest, head over to the website.
In this episode, we're going to dig into my feelings about this business and podcast.
This essay is going to be both a little bitter, and a little sweet on the palate. Parts cooked, parts raw.
Because sometimes I feel up against a wall with Welly P. So we're going to jump into what I mean by that.
Here is my...2023-07-1217 min
Happy Space Podcast with Clare KumarWork from anywhere… but what about borders? - with John LeeWe’ve seen a dramatic rise in people working from home through the pandemic, but what about our digital nomads and remote workers, and others who wish to explore our world while they work. For organizations that wish to draw from a global talent pool and benefit from the diversity that it inherently brings, you’ll want to stay on the right side of the the law…especially as they are evolving.Joining me today is the co-founder of Work From Anywhere and remote work compliance specialist, John Lee. Having already launched a startup related to cultural unders...2023-07-0334 min
Collaborative Resource Hub: Wellness in Rock and RollWellness in Music: An Interview with Linh Le of Bad Cop Bad Cop | Fat Wreck Chords | Bassists Against RacistsLinh, bassist of Bad Cop Bad Cop, shares some truths and reflects on all the different elements that help us become better versions of ourselves.
We chat about:
Healthy boundaries
Perfectionism
Beauty and imperfections
Self-talk and self-kindness
How she balances her stress levels
Connect with Linh:
Photo Credit: Tony Smith @tonysmith_images
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OHNE AKTIEN WIRD SCHWER - Tägliche Börsen-News“Nubank rasiert die Bankenwelt” - Foot Locker fällt 27% & CRH mag BidenDas Buch zum Podcast? JETZT vorbestellen.Lieber als Newsletter? Geht auch.DAX hat Rekordhoch. Nikkei hat 33-Jahreshoch. USA hat kein Hoch, sondern ein Schuldenproblem. Ansonsten war die Stimmung bei Foot Locker miserabel und Micron geht’s dank China auch schlecht. Aber bei Google wird dank Samsung gefeiert.Zuschlagstoffe, Infrastrukturprogramme und Übernahmen sind das Geheimnis von CRH (WKN: 864684). Ein Geheimnis, das bald vielleicht auch die US-Investoren verstehen.Starkes Wachstum beim Umsatz. Langsames Wachstum bei den Kosten. So lautet das Geheimnis und...2023-05-2212 min
Collaborative Resource Hub: Wellness in Rock and RollWellness in Music: An Interview with Tom Wisniewski of MXPX | Pop Punk Guitarist | Weight Loss TipsTom, guitarist of MXPX, shares the why and the how behind his weight loss journey. He passes on first hand experiences, tips and advice for those interested in bettering their health; and his positive outlook is inspirational.
We chat about:
How he balances stress
What perseverance looks like to him
His love of nature, hiking and yoga
The most magical show MXPX has played
Connect with Tom:
https://mxpx.com/
https://www.instagram.com/tomwisniewski/
https://www.instagram.com/mxpxpx/
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2023-05-0354 min
The Plan B CRNA PodcastSpecial Guest - From the Corporate Side with Daniel Myers Part 2Daniel Myers discusses his interactions with anesthesia providers in different clinical sites and some funny stories that came out of it. He also talks about locum companies' strategies to get providers' information and how to decrease their rate of reach, including requesting to be removed from their communication lists. He also shares his company's unique and revolutionary process of sourcing candidates and how they do not blow up CRNAs' phones or emails with mailing lists or excessive advertising.Daniel Myers is the Director of Recruitment for CRH Anesthesia and CRH Medical...2023-04-1719 min
Market MakerMM103: The demise of the London Stock Exchange as Arm and CRH chose New YorkIn this episode, Piers and I unpack the headline 'Fears for the future of the London Stock Exchange' as SoftBank and the world’s largest building materials group CRH, shunned the City in favour of New York.We look at where London sits in the context of the global exchanges, what makes New York more attractive and what can the UK government do to stop what has been a gradual decline of the UK's influence over the past 170 years.Free daily newsletter https://bit.ly/3Oeu4WkFree Finance Accelerator simulation http...2023-03-0338 min
Collaborative Resource Hub: Wellness in Rock and RollWellness in Music: An Interview with Brenna Red of The Last Gang | Fat Wreck ChordsBrenna, total badass, amazing friend to many, and Disney-obsessed front woman of The Last Gang sits down and shares her take on all things mental health - from how she’s evolved as a teenager, to her core values that make her marriage awesome. This was a really fun chat!
We chatted about:
What keeps her level and feeling her best in the day to day
How she sets healthy boundaries
Dealing with adversity and negative people
The benefits of cutting out alcohol
Sleep routines
Connect with Brenna:
https://www.ins...2023-03-0138 min
Collaborative Resource Hub: Wellness in Rock and RollWellness in Music: An Interview with Hunter Burgan of AFI | A Fire Inside Bassist | Bass Guitar TipsHunter, bassist for AFI, hangs out and shares all kinds of stuff in this conversation. A dedicated pet parent, this chat kicks off with about 10 minutes of what it’s like to be a cat or dog in Hunter’s house, before dropping insights into sleep, being creative, and PMA!
We chat about:
The positive impact of having routines
What keeps him level headed in the day to day
His father’s music
And of course Boogie, Rocky II and Lula
Connect with Hunter:
https://www.instagram.com/hunterburgan
https://www.instagram.com/afireinside
https://hoo.be/a...2023-02-011h 04
Diálogos de Política Exterior#29: Relações Brasil-ÁfricaOlá, sejam bem vindos, bem vidas e bem vides! Essa é a segunda temporada do Diálogos de Política Exterior- seu podcast quinzenal sobre política externa brasileira.
No 29° episódio do Diálogos de política Exterior, receberemos o Mestre Lucas Oliveira Ramos para conversar sobre as Relações Brasil- África .
Por fim, se você se interessa pela temática, indicamos algumas produções muito interessantes:
Canal no YouTube "O Lugar da África na Política Externa Brasileira" https://www.youtube.com/watch?v=X28sPmxZgXs
MADUREIRA, Fernando Pinto. As relações Brasil- Á...2023-01-2636 min
Market Vitals Daily Podcast w @MissTrade @HFRfromtheFloorRoman concrete, is so hot right now $CRH @hfrfromthefloor cheers @lions @AaronRodgers12 going snowbird 2023? @TCUFootball Plus 14Roman concrete, is so hot right now $CRH @hfrfromthefloor cheers @lions @AaronRodgers12 going snowbird 2023? @TCUFootball Plus 14 @AustralianOpen all Covidiots are welcome @DjokerNole I wonder if @RafaelNadal will boycott? $UB_F lofty $ES_F $NQ_F $ZB_F This is a public episode. If you would like to discuss this with other subscribers or get access to bonus episodes, visit misstrade.substack.com2023-01-1038 min
Collaborative Resource Hub: Wellness in Rock and RollWellness in Music: An Interview w/ Greg Hetson of Circle Jerks, Punk Rock KaraokeGreg, guitarist for legendary Circle Jerks and allstar group Punk Rock Karaoke, sits down and shares what improvements he’s made on his path to self-betterment.
We chat about:
Recovery
Balancing stress levels
Healing through depression and anxiety
Connect with Greg:
https://www.instagram.com/greghetson/
https://www.circlejerks.net/
https://www.instagram.com/punk_rock_karaoke/
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🍄...2023-01-0435 min
Collaborative Resource Hub: Wellness in Rock and RollWellness in Music: An Interview with Mike Mulé of Doc Hammer | San Diego, CA Party Rock'n'Roll BandMike, the charismatic guitarist for Doc Hammer out of San Diego shares what keeps his mental health on the level day in and day out.
Make sure to catch the outtakes at the end!
We chat about:
What keeps him feeling healthy and balanced on and off the road
How he stays organized w/o getting overwhelmed
Setting healthy boundaries
Mindfulness
Connect with Mike:
https://www.instagram.com/donthasslemeimlocal
https://linktr.ee/doc_hammer_band
https://sweetbeef.agency
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CRH TalkHand Hygiene is Vital!Heather Bates, CRH Infection preventionist, joins us on CRH Talk to discuss hand hygiene awareness week and what you should be aware of. Please follow her recommendations to keep everyone safe this holiday season.2022-12-0411 min
Collaborative Resource Hub: Wellness in Rock and RollWellness in Music: An Interview with Lenny Lashley of Lenny Lashley's Gang of One | Sobriety TipsLenny shares about his sobering experiences and what his path to recovery from drugs and alcohol looks like to him. You’ll be motivated by this chat - especially if you’re early days in recovery.
We chat about:
How he keeps himself centered on a daily basis
How he applies the Law of Attraction in his life
Books that have been instrumental in his growth, and why
Photo by: Jonathan Buckley
Connect with Lenny:
https://www.instagram.com/lennylashley/
https://lennylashleysgangofone2.bandzoogle.com/home ...2022-11-3047 min
Collaborative Resource Hub: Wellness in Rock and RollWellness in Music: An Interview with Roy Krebs of Natural Stacks | Brain Health | NeurotransmittersOur GUIDE INTERVIEW SERIES offer you a wealth of concentrated information and insight. 💣 Knowledge bombs dropped by really smart people.
Roy, founder of the leading brain health company Natural Stacks, hangs out and gives us a crash course in neurotransmitters and all things brain health. He provides a fantastic overview on how our brain and body functions and what that means for your mood and personality.
We chat about:
Gut Health + Brain Health Connection
GABA + anxiety
Serotonin + happiness
Dopamine + procrastination
Acetyl Choline + focus
Hormones + Neurotransmitters
Wellness Provisions sells all the Natural Stacks products we talk...2022-11-1639 min
Collaborative Resource Hub: Wellness in Rock and RollWellness in Music: An Interview with Rick Thorne Pro BMX Rider | Good Guys In Black | LA PunkRick Thorne, proBMXer and front man to Good Guys In Black, brings us into his world and shares about his experiences through marriage, fatherhood, and all his creative endeavours. PMA is definitely a cornerstone to this chat.
We chat about:
Self-growth and self-awareness spurred from marriage
Evolving as an athlete
Thoughts on overthinking and getting out of your head
Cooking and healthy eating
Connect with Rick:
http://www.rickthorne.tv
http://www.goodguysinblack.com
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CRH TalkHere's how our chef prepares 500 mealsNeed some great holiday meal tips for 2022? Join CRH Talk as our Executive Chef, Doug Williams, shares his love for food and how food can make people feel. His team will be providing 500 meals for those who want a delicious Thanksgiving Day meal for themselves and a loved one.
Please join us on Thanksgiving Day from 11:00 AM to 1:00 PM at Cody Regional Health's Monument Entrance located at 707 Sheridan Avenue, Cody, WY 82414.
***All donations will go towards next year's meal. For more information please email crh@codyregionalhealth.org or visit codyregionalhealth.org.2022-11-0916 min
Somos CidadeDanilo Conti fala sobre o Cidades das águas, um bairro planejado em Joinville que tem gerado expectativa no mercado imobiliárioDanilo Conti é Diretor Geral da Cidade das Águas em Joinville, um bairro planejado que tem gerado expectativa no mercado imobiliário brasileiro.
Parceria entre CRH (controladora do Grupo Tigre) e Grupo Pedra Branca, o Cidade das águas bebe da experiência de 20 anos da Cidade Pedra Branca em Palhoça/SC, evitando os erros cometidos e adotando o estado da arte em desenho urbano.
No bate-papo, Danilo dá detalhes sobre o projeto e seu andamento, fala sobre o Musicarium, um presente para a cidade de Joinvile, explica como será o modelo de negócio e relaciona...2022-11-0153 min
Collaborative Resource Hub: Wellness in Rock and RollWellness in Music: An Interview with Matt Watkins of Toxins, Human Issue | San Diego punk hardcoreMatt, the dynamic singer of San Diego based Toxins, shares what wellness means to him, airing on the mental health side of wellness. This chat is as honest as the lyrics he writes for his music.
We chat about:
How he keeps himself feeling balanced
Journaling and his songwriting process
Skateboarding
Plus random tangents about food
🎉And be sure to catch the outtakes at the very end!
Connect with Matt:
https://www.instagram.com/wearetoxins
https://linktr.ee/Toxins
https://www.instagram.com/humanissue.music.collective
https://www.instagram.co...2022-10-2644 min
Collaborative Resource Hub: Wellness in Rock and RollWellness in Music: An Interview with Chris Beattie of Hatebreed | Victory Records | hXc Bassist BJJChris, bassist for Hatebreed and jiu jitsu badass, welcomes us into his corner of the world and how he balances band life, dad life, and time for himself.
We chat about:
Mental toughness and dropping your ego in jiu jitsu
How he stays balanced and healthy in body and mind
His core values in being a dad
Connect with Chris:
https://www.instagram.com/godofbass/
https://beattierealestate.com/
https://www.instagram.com/hatebreedofficial/
https://linktr.ee/hatebreed
Photo credit: Jon Freed
2022-10-1256 min
CRH TalkWe hired an ER Clinic Supervisor/Trauma Coordinator!We invited Danielle Mong, our new Clinical Supervisor, and Trauma Coordinator, to CRH Talk to explain her new role within our Emergency Department.
Her dedication to patient care and follow-up is amazing.
Danielle has a lot of experience and is a vital part of our team at CRH.
We hope you enjoy this talk as much as we did! Trauma coordination is something that happens on the backend and we sometimes forget what it takes to care at a level that surpasses our expectations.
For more information about our Emergency Services...2022-10-1012 min
Collaborative Resource Hub: Wellness in Rock and RollWellness in Music: An Interview with Randy Bradbury of Pennywise | Punk Rock Bassist So CalRandy, bassist for Pennywise, is an intelligent free thinker who embraced mental toughness at a young age and created a healthy life for himself. This interview rules so hard.
We chat about:
Creating a healthy lifestyle out of a messy wild youth
Going inwards and answering to no one but yourself
Mental toughness, serving others and having a purpose
Connect with Randy:
https://www.instagram.com/randybradbury/
https://pennywisdom.com/
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CRH TalkCody Regional Health Introduces New Electronic Health Record SystemAt Cody Regional Health (CRH), we are completing a system-wide launch of our new Electronic Health Record (EHR) system called EPIC starting on October 1, 2022. The simultaneous go-live will encompass all of CRH’s medical clinics around the Big Horn Basin Region, which will exchange secure patient records across a single sharing platform. The EPIC system is made possible partly through a partnership with St. Vincent Healthcare, now part of Intermountain Healthcare. CRH patients will be able to use a new digital tool called CRH MyChart, allowing them to easily locate personal health information on demand. They will also be ab...2022-09-2513 min
Collaborative Resource Hub: Wellness in Rock and RollWellness in Music: An Interview with Tom Blyth of Toy Dolls | Goober Patrol Fat Wreck Evil ConductTom, bassist for Toy Dolls and super talented artist, shares his experiences around music and life, as well as top advice to live by that he’s instilling in his daughter.
We chat about:
Fatherhood and how that shaped him
Balancing sobriety and wellbeing in a punk band
Assimilating to a new culture and laying roots in another country
Connect with Tom:
http://www.thetoydolls.com/
https://www.instagram.com/tom_goober/
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Collaborative Resource Hub: Wellness in Rock and RollCRH Bonus Episode: Why We Sleep *Excerpt* by Matthew Walker | Alcohol Caffeine Effects on SleepThis is a bonus episode for the Collaborative Resource Hub Podcast. I just finished reading this book and wanted to share some parts I thought my loyal listeners of Welly P would find valuable.
I read the following chapters:
Sleep: An Introduction
Sleep Pressure & Caffeine
Turning Down The Nightcap - Alcohol
Sleep Solutions: Top 12 Tips
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🍄Incredible clean-ingredient, plant-based protein powder
🍄Organic coffee boosted by mushrooms t...2022-09-1427 min
Collaborative Resource Hub: Wellness in Rock and RollWellness in Music: An Interview with Candace Puopolo of Walls of Jericho | Female Singer Metalcore HardcoreCandace, singer of Walls of Jericho and trainer shares how the gym is a metaphor for life; how movement creates growth. She inspires and motivates in this interview from her own experiences, and helps you to see things from a different perspective.
We chat about:
Having a purpose and a why, both in the gym and in life
Why exercise matters and how different types affect your mind and body
Plus we touch on modalities for healing trauma and self-growth
Connect with Candace:
https://www.instagram.com/candace_woj/
https://www.i...2022-09-0752 min
Collaborative Resource Hub: Wellness in Rock and RollWellness in Music: An Interview with Colin Harte of Neckscars | New York Punk RockColin, bassist of New York’s very own Neckscars shares his level headed thoughts on all things wellness. We have a thoughtful dialogue about helping others and helping yourself.
We chat about:
Relationships and reaching out
Curbing overthinking
How he processes what life throws his way
Running, bicycles and Yoga
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🍄Incredible clean-ingredient, plant-based protein powder
🍄Organic coffee boosted by mushrooms to support your body & redu...2022-08-3145 min
CRH TalkVirtual Reality in HealthcareCody Regional Health Foundation and Patient Experience Director, Annalea Avery, joins CRH Talk to share about our new Virtual Reality Goggles, The Ridgeline Membership, and an upcoming Ireland Trip you can win!!! For more information about CRH Foundation and what they offer please visit CRHGive.org today or call (307) 578-2338!2022-08-3010 min
Collaborative Resource Hub: Wellness in Rock and RollWellness in Music: An Interview with Chris Shary | Punk Artist for Descendents 7 Seconds Rancid ALLChris, punk artist (Descendents!) and family man is incredibly insightful, thoughtful, and wicked talented with a Sharpie marker! He shares how he finds balance in a very busy, art-filled life. This is a fun, fast-paced interview!
We chat about:
Time management and balancing life as a teacher, artist, father and husband
What helps him stay organized and productive
The importance of prioritizing time between family and work
Connect with Chris:
https://chrisshary.bigcartel.com/
https://www.instagram.com/chrisshary
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Collaborative Resource Hub: Wellness in Rock and RollHas Self-Help Driven You Crazy? | The Delay Dying Blog: Podcast Edition | Self Help Motivation TipsCan you trust your thoughts? Are you lost in a maze within your head? But all the while, you're reading lots of self-help content?
You may have just crossed the threshold into too much self-help. Yep, it's a thing - and you just found the limit. Congratulations.
This episode explores:
💥Why you may have ventured into those self-help waters in the first place
💥And how you can get yourself out of that mental maze and feeling better
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Collaborative Resource Hub: Wellness in Rock and RollWellness in Music: An Interview with Violet Mayugba of Destroy Boys | California punk singer guitaristViolet, singer and guitarist of Destroy Boys shares her take on all things wellness, including great insights into therapy, plus her obsession for cooking! She has some killer insights into therapy.
We chat about:
Why therapy rules, Anxiety, Inner Child VS Inner Teenager work
Growing up and evolving as a person
Cooking and ingredients
Astrology
And cats!
Connect with Violet:
https://www.destroydestroyboys.com/
https://www.instagram.com/destroyboysband/
https://www.instagram.com/violetmayugba/
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Collaborative Resource Hub: Wellness in Rock and RollWhat Remedies Are Good For Anxiety? | The Delay Dying Blog: Podcast Edition | Mood Balance SupportThis is The Delay Dying Blog: Podcast Edition. All essays are written by Amy McBride. Only select essays appear on the podcast. To check out the rest, head over to the website.
This episode covers:
Three Wellness Kits by Wellness Provisions that promote mental health and mood support
We’ll break down the Mood Support Kit, the Stress Support Kit and the Healthy Cognition Kit
This episode IS lively and interesting because I know hearing about supplements can be a wall of noise!
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Collaborative Resource Hub: Wellness in Rock and RollWellness in Music: An Interview with Hunter Martinez of Decent Criminal, Human Issue | Drummer | ex-DwarvesHunter is a badass drummer. He plays full time in Decent Criminal, is the mastermind behind Human Issue, contributes to countless other bands, and is the former drummer of the Dwarves.
He lets us into his world as we hang out and talk drums, tour life and wellness. It’s a fun and inspirational conversation.
We chat about:
Gratitude
The concept of time
Staying healthy on tour
The importance of family and friends
What being healthy looks like to him now
Connect with Hunter:
https://www.instagram.com/h_criminal/
h...2022-07-201h 07
Collaborative Resource Hub: Wellness in Rock and RollWhat is Holistic Healing? | Delay Dying Blog: Podcast Edition | Holistic VS Conventional MedicineThis is The Delay Dying Blog: Podcast Edition. All essays are written by Amy McBride. Only select essays appear on the podcast. To check out the rest, head over to the website.
This episode covers:
💥 What parts of your life and health play into a holistic approach
💥 Different types of modalities that promote healing holistically
💥 What to do if you feel overwhelmed
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Collaborative Resource Hub: Wellness in Rock and RollWellness in Music: An Interview with Mike Gallo or Agnostic Front | NYHC Bassist | Street ArtMike, bassist for legendary NYHC Agnostic Front as well as artist, shares his insights into all things wellbeing and fatherhood. Mike has creativity in his blood, no doubt.
We chat about:
His artistic process
His early days of playing bass in AF
Muay thai and combat sports
What inspires his creativity
Being a dad
Connect with Mike:
https://www.instagram.com/mikegallo1975/
https://www.instagram.com/agnosticfrontnyc/
https://www.facebook.com/agnosticfront
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Collaborative Resource Hub: Wellness in Rock and RollHow To Have Self-Discipline | Delay Dying Blog: Podcast Edition | Does adversity make you happier?This is The Delay Dying Blog: Podcast Edition. All essays are written by Amy McBride. Only select essays appear on the podcast. To check out the rest, head over to the website.
This essay covers:
If adversity makes people happier
How your environment impacts you
What's the deal with "going with the flow"
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🍄Incredible clean-ingredient, plant-based protein powder
🍄Organic coffee boosted by mushrooms to s...2022-06-2908 min
Everyday Green HomeDesigning Wellness In with Christy Howell of CRH Design BuildLately, I’ve been talking about health and wellness and how much it impacts our living environment. That means how we design, build or remodel a house or building, how we live in it, and how we interact with it. I’m Marla, the Green Home Coach! For the last few months, I have hosted one of my business partners on the podcast. It has been exciting to build a group of people who care about how people live in their homes! Today, I am happy to have Christy Howell of CRH Design Build back on the...2022-06-2935 min
The British Broadcasting Century with Paul Kerensa#047 ”Hark, The Engine’s Failing”: The Closedown of 2MT WrittleJanuary 17th 1923: 2MT Writtle, Britain's first regular broadcasting station, closes down for the last time.
Its chief voice, director of programmes, Lord of Misrule Peter Pendleton Eckersley toasts its listeners with a glass of water, upgraded to champagne via the use of a pop gun - innovating to the last with one of radio's first ever sound effects. Then Eckersley, the first BBC-basher, switched sides and promptly joined the BBC, as its first Chief Engineer.
On episode 47, we've reached the moment where the BBC's peculiar airwaves rival finally shuffles off the ether, having somehow given...2022-06-0338 min
Regenerati Neurologia - Dr. Willian RezendeAnsiedade - Causas Genéticas De Ansiedade🎯 Consulte Com Um Especialista Agora (Online ou Presencial)! https://willianrezende.com.br/emocoes
00:00 - Ansiedade - Causas Genéticas De Ansiedade
00:51 - A ansiedade pode ser de origem biológica?
Sim, a ansiedade tem origem biológica. A ansiedade é uma forma de preparação biológica do corpo para agir, antes do “perigo” chegar.
02:54 - O que é ansiedade?
Ansiedade é um sentimento vago e desagradável de medo, apreensão, caracterizado por tensão ou desconforto derivado de antecipação de perigo, de algo desconhecido ou estranho.
04:27 - Bases biológicas da ansieda...2022-05-1811 min
CRH TalkCRH Foundation Spring UpdateCody Regional Health Foundation & Patient Experience Director, Annalea Avery joins CRH Talk to discuss what's going on in the Foundation office!
Learn more about where your donations can go at: https://www.codyregionalhealth.org/crh-foundation/ways-to-give/
Want to shop for a loved one? Purchase something from the CRH Giftshop at: https://www.crhgiftshop.org/
To learn more about becoming a volunteer with the CRH Foundation, please visit: https://www.codyregionalhealth.org/careers/volunteer/
Thank you for listending!2022-04-0511 min
NSSGA PodcastBeing Mindful of Safety Equipment with Ericka BaxterSenior Environmental Director for the Central West region of CRH, Ericka Baxter, joins Libby for today's episode. Ericka takes this opportunity to talk about environmental safety and health, and share a story about an oil spill at one of CRH's locations that was handled extremely well. Episode Highlights: There are a lot of safety concerns when it comes to environmental matters, especially when dealing with oil and fuel At one of CRH's sites, a contractor's truck blew a hydraulic hose Thanks to the fact that the contractor and the site supervisor both had w...2022-02-0304 min
Collaborative Resource Hub: Wellness in Rock and RollWellness in Music: An Interview with Bill Stevenson of DescendentsBill, the much loved and energized drummer of the Descendents, sits down and shares his healthy habits and thoughtful perspective on life. I adored this conversation, hearing about what elements of wellness he prioritizes and how he’s able to drum like he’s still 19!
We chat about:
The importance of exercise and movement
Healthy eating, nutrition and cooking
Breathwork and meditation
Sleep
Supplements
Connect with Bill:
Descendents https://www.instagram.com/descendents/
The Blasting Room https://www.instagram.com/theblastingroom/
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2022-01-0552 min
Illegal OpinionsEp 99: "Just Keep Pulling On It"Welcome back to the Illegal Opinions Podcast, and once again we got Cynthia on the track. (4:06) Cults are a real thing because one of us was in one, (8:48) and we discuss how holiday plans change as you get older. (18:50) CRH came out of the closet to her family as a vegan; we also discussed parting with certain traditions, (28:58) and what is the vegan equivalent to a crab leg? (34:15) What roles would you like to see your favorite actors/actresses in, (45:52) and how often are they misrepresented by their roles? (59:00) CRH opens up about why her defenses are up in e...2021-12-261h 27
Collaborative Resource Hub: Wellness in Rock and RollWellness in Music: An Interview with Brendan Kelly of The Lawrence Arms | Epitaph RecordsBrendan from The Lawrence Arms offers up a fun conversation with a lot of laughs while relaying his grounded insights into all things wellness. You’ll smile a lot listening to this episode.
We chat about:
The idea that creativity equates to wellness
His inspiration and songwriting process
Managing panic attacks
Balancing fun and healthy choices on tour
Getting banned from Warped Tour and the good that eventually came out of it
Connect with Brendan:
https://www.instagram.com/thelawrencearms/
https://thelawrencearms.bandcamp.com/
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Between Two SilosMarket Intelligence: Compliance LawsHost: Justin Fleming, Sales Manager for Ash Grove
Guests: Elizabeth Ames, Compliance Counsel for CRH and Jennifer Good, General Counsel for CRH
Listen and learn about the ins and outs of compliance law as it relates to market intelligence. Topics range from what are compliance laws to the importance of good market intelligence documentation. When in doubt always contact the law group at 1-800-241-7074 or lawhelp@crh.com.2021-07-2833 min
The Obermatt PodcastCRH Kaufen - auf Anraten eines Obermatt Nutzers im Zoom TalkObermatt CEO Dr. Hermann J. Stern kauft CRH weil ein Obermatt Nutzer dort arbeitet und interessante Einsichten hatte.
2021-07-2305 min
Cooperativismo por Puerto RicoCon el Atleta Christian Colón y CRH COOPEn esta ocasión nos acompaña el joven coameño Christian Colón, quien es un atleta fondista que ha representado a Puerto Rico en eventos deportivos internacionales. También, se integra la Sra. Luz N. Rodríguez, quien es Oficial de Mercadeo en la Cooperativa de Ahorro y Crédito Cristóbal Rodríguez Hidalgo (CRH COOP). Conversamos sobre la trayectoria deportiva de Christian Colón, así como el auspicio que le ha brindado CRH COOP para alcanzar sus metas y continuar desarrollando sus talentos.2021-06-1617 minBetween Two SilosProfiles in Leadership: Monica ManolasHost: Justin Fleming, Sales Manager for Ash Grove
Guest: Monica Manolas, President South Region for Ash Grove
In this Leadership Series, hear from our very own Monica Manolas as she shares insights she has learned on her leadership journey. This episode is full of advice, inspiration, and a whole lot of personality!2021-05-1736 min
Collaborative Resource Hub: Wellness in Rock and RollWellness in Music: An Interview with Milo Aukerman of the DescendentsMilo Aukerman from the Descendents sits down and speaks to all things wellness and science in this chat.
We touch on:
💥Caffeine consumption
💥Exercise
💥His strategies around moderation
💥What eating healthy looks like to him
💥Why trees are important to us and how they communicate with each other
💥What helps him as a vocalist and what inspires his creativity for songwriting
Connect with the Descendents:
https://www.descendentsonline.com
https://www.instagram.com/descendents/
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❗️❗️SPECIAL WELLY P OF...2021-04-2047 minBetween Two SilosAsh Grove's Market Intelligence Task ForceHost: Justin Fleming, Sales Manager for Ash Grove
Guest: Ernie Peterson, Vice President Sales - Central for Ash Grove; Wendy Brown, Business Market Analyst for Ash Grove
Hear Ernie and Wendy discuss the market intelligence task force's goals and how information is shared and used. Learn about resources that are available and how you can contribute to the success of collecting and sharing information from legitimate sources.2021-04-0119 minBetween Two SilosWorking RemotelyHost: Justin Fleming, Sales Manager for Ash Grove
Guests: Sy Steppacher, Cement Sales & Logistics for Ash Grove
Listen and learn about Sy's experiences working remotely, including tips and suggestions to make the most out of windshield time. His journey from other lines of business to sales is informative and may inspire you when thinking about your career with CRH.2021-04-0123 min
CASAContact33. Le cas de Groupe CRH Canada avec Mejasoa RazafimiharyLa pandémie a complètement bouleversé nos vies et nos méthodes de travail. Cette nouvelle réalité génère des enjeux de communication interne et de mobilisation des employés pour les organisations. Comment maintenir l’attention et la motivation des employés? Voilà le grand défi de l’heure, selon Groupe CRH Canada, une société de matériaux et de services de construction. Dans cet épisode de CASAContact, Jean-Michel Nahas, notre vice-président directeur et associé en discute avec Mejasoa Razafimihary, directrice des communications et du marketing chez Groupe CRH. Bonne écoute!2021-03-0210 min
KeyStone’s Stock Talk – Canadian & US Small-Cap Growth & Dividend Stocks, Tips & Portfolio Building StrategiesStock Talk Podcast Episode 132To start this week, we highlight a couple of Stars from our coverage universe. The first, Sangoma Technologies Corporation (STC:TSX-V) is a Communications as a Service or (CaaS) solutions for businesses of all sizes. In the past week the company made a US$437 million transformational acquisition of Star2Star Communications, a top-ten vendor of cloud communications solutions in North America. After resuming trading Monday, the stock has jumped 35% in two days from $3.87 to $5.20. Sangoma was recommended to clients 3 years ago at $0.72 – now a 630% gain to clients – congratulations to those who own the stock!
The second star of t...2021-02-1029 minBetween Two SilosAsh Grove Technical Services Interview with Heath HallHost: Justin Fleming, Sales Manager for Ash Grove
Guest: Heath Hall, Technical Services Manager for Ash Grove
Hear from an Ash Grove Technical Services Manager about his unique role on the commercial team and how he supports our customers. His journey from the cement plant to sales is informative and may inspire you to consider all options when thinking about your career with CRH.2021-02-0435 min
Between Two SilosCommercial Excellence Interview with Beau BouldenHost: Justin Fleming, Sales Manager for Ash Grove
Guest: Beau Boulden, VP Commercial Performance Group
Hear Beau discuss the commercial excellence framework and how it is used for planning, strategy, and measuring success. In addition, he shares more about his role and the national performance teams. Did anyone say Etouffee?2021-02-0414 minBetween Two SilosAsh Grove Academy Origins with BLSHost: Justin Fleming, Sales Manager for Ash Grove
Guests: Sarah Blake, Blake Learning Solutions; Crystal Monson, Blake Learning Solutions
Hear about the instructional design process and how Blake Learning Solutions joined forces with one of Ash Grove's commercial task force teams to build a framework for the Ash Grove Academy.2021-02-0429 minBetween Two SilosSuccess Profile Interview with Mickey and MeghanHost: Justin Fleming, Sales Manager for Ash Grove
Guests: Mickey Scherer, VP Talent and Leadership Development; Meghan Walsh, Talent Project Manager
Do you know the secret to success? For CRH, it can be found within a Success Profile. Spend some time with Mickey and Meghan and learn about Success Profiles and how they can help hiring managers find the right fit during the interview process, and guide our employees with their professional development goals.2021-02-0414 min
Authentic BiochemistryFear and Aging associated with neuronal conditioning and synaptogenesis via corticotropin releasing hormone. Dr. Dan Guerra; Authentic Biochemistry 13 JAN 2021•Intensive and chronic or excessive stress diminishes intellectual performance and general cognition: this is a form of negative reinforcement and can be related to learning disability and anxiety about future events. Indeed, •Individual responses and the magnitude of stressor as well as its association with self identity and goals will influence endurance, resilience, and self-empowerment vs. dissatisfaction and defeat.
•Stresses first become recognized in the developing fetus since the fetal brain attains awareness during the first trimester and maternal stress is well established as an epigenetic mechanism involved in fetal neural development and stress is lifelong , contributing to one’...2021-01-1329 min
Everyday Green HomeCool Home, Concrete Home with Christy HowellToday, we’re happy to have Christy Howell, from CRH Design + Build, joining us. Christy was on the show previously, about a year-and-a-half ago, when her business was going through a transition phase. She is currently building a pilot home using the incredible ICF (Insulated Concrete Form) technology blocks, which she describes as being like large Lego blocks for adults. Building a home with this innovative new green technology has many benefits. In today’s episode, Christy will talk to us about the myriad advantages of building a house in this way. What CRH Design + Build...2020-06-2435 min.JPG)
Lets Go To Work with Dean & DerekCRH Americas 2020Listen to our ongoing interview with CRH Americas’ John Kemp, President of the Building Solutions Group. John connects CRH materials and people to local relationships in the construction industry. From aggregates, asphalt, and cement, to the ACE Mentor program and AWARE Safety System, hear how CRH is putting safety first and building future leaders, not … Continue reading CRH Americas 20202020-01-3123 min
Women in Security PodcastS1E8 - Lydia Behan on investigations, reverse culture shock and Girls in TechLydia Behan joined CRH, one of the world's leading building materials companies, in 2018. She joined the organization after moving back to Dublin from Toronto, Canada where she was a member of the Fraud and Financial Crimes Management Group at TD, the largest bank in Canada. At TD, Lydia was responsible for the management and development of the Threat Intelligence and Cyber-Enabled Fraud practice. Prior to TD Bank, she has several years of experience at PwC Canada in both Forensic Technology Services and Cybersecurity consulting, working alongside both Canadian and international clients across a wide range of industries.
...2019-11-0535 min
Global Business Talk RadioJohn Lee of Culture Mee, IrelandJohn Lee of Culture Mee, Ireland
John has extensive experience travelling to and working with different cultures, and has seen first-hand the power of getting culture right.
CultureMee is one of the only travel start-ups in the world to have won global awards in both business and leisure travel.
It was founded by husband and wife team Dee and John Lee. Between them they have traveled to over 80 countries and even brought their baby daughter Rosa with them who by the time she was 2 years of age had already traveled to 23 countries!
John and Dee welcomed their second daughter Esmé int...2019-09-2700 min
CX NetworkEp. 119: Andrew Parris, CRH plcAndrew Parris,Director Of Performance Improvement at CRH, focuses his efforts on improving corporate functions across the board, including finance, IT, procurement, and HR. How does he do it? Data-backed benchmarking, implementation planning, and change management. Additionally, intelligent automation is taking a front seat. “We're starting to bring some AI into play. Our approach has always been, it's not just about the bot, it's about the right solution for the right problem.”2019-07-2436 min
The AI Network PodcastEp.108: Andrew Paris, CRH plcAndrew Parris, director of performance improvement at CRH, focuses his efforts on improving corporate functions across the board, including finance, IT, procurement, and HR. How does he do it? Data-backed benchmarking, implementation planning, and change management. Additionally, intelligent automation is taking a front seat. “We're starting to bring some AI into play. Our approach has always been, it's not just about the bot, it's about the right solution for the right problem.2019-07-1935 min
PEX Network | Process Excellence NetworkEp. 118: Andrew Parris, CRH plcAndrew Parris,Director Of Performance Improvement at CRH, focuses his efforts on improving corporate functions across the board, including finance, IT, procurement, and HR. How does he do it? Data-backed benchmarking, implementation planning, and change management. Additionally, intelligent automation is taking a front seat. “We're starting to bring some AI into play. Our approach has always been, it's not just about the bot, it's about the right solution for the right problem.”2019-07-1636 min
BetterHealthGuy BlogcastsEpisode #58: Mast Cell Master with Dr. T.C. Theoharides, PhD, MDWhy You Should Listen: Why You Should Listen: In this episode, you will learn about mast cell activation syndrome (MCAS) and some key considerations when treating this common issue seen in those with Lyme disease, mold illness, autism, and other complex conditions. About My Guest: My guest for this episode is Dr. Theo Theoharides. Dr. Theo Theoharides, PhD, MD has studied the regulation of mast cell activation and its role in neuroinflammatory disease for over 30 years. He holds a Masters in Neuroimmunology, a PhD in Pharmacology, and an MD from Yale University. He was...2018-01-301h 58
KeyStone’s Stock Talk – Canadian & US Small-Cap Growth & Dividend Stocks, Tips & Portfolio Building StrategiesStock Talk Podcast Episode 29We have another busy show for you this week. We start off by updating what has become an ongoing bidding war for small-cap networking equipment company Sandvine Corp. (SVC:TSX) – this seems to be a weekly segment. We also question if the Canadian economy is in a precarious position at present. In our Your Stock, Our Take segment we take a question from a listener about Canadian small-cap, Quarterhill Inc. (WIN:TSX) a company which recently “pivoted” its business model and with a huge cash war chest is focussed on acquiring technology companies in the Industrial Internet of Things (IIoT) – we see i...2017-07-1434 min
Fakultät für Biologie - Digitale Hochschulschriften der LMU - Teil 05/06Gene-environment interplay of extreme anxiety-related behaviorThe use of selectively bred mouse models of enhanced fear and/or anxiety-related behavior provides a unique opportunity to identify genetic targets that contribute to pathological anxiety. However, dealing with animal models needs accurate information about their phenotypes. Accordingly, high (HAB), normal (NAB) and low (LAB) anxiety-related behavior mice – a validated model of anxiety disorders - were repeatedly tested in a variety of behavioral paradigms. Whereas most tests to assess anxiety traits are based on fear of novel and open spaces, we took advantage of the inborn fear and associated avoidance of the predator odor (trimethylthiazoline (TMT)) as a measure of...2014-06-2600 minMedizinische Fakultät - Digitale Hochschulschriften der LMU - Teil 15/19fMRT-Ruhenetzwerke gesunder ProbandenDie Hypothalamus-Hypophysen-Nebennierenrinden-Achse (HPA-Achse) ist ein hierarchisch organisiertes, neuroendokrines System, das unter anderem die Freisetzung des Nebennierenrindenhormons Kortisol, dem zentralen Hormon der Stressantwort und der Homöostase des Organismus in Bezug auf die Anpassung an Umweltanforderungen, regelt. Die HPA-Achse ist in ein komplexes System von Regulationsnetzwerken eingebunden, über die der Organismus die Anpassung an ständig wechselnde Anforderungen erfasst und steuert. Fehlanpassungen der HPA-Achse sind hierbei von großer klinischer Bedeutung, da sie zu psychiatrischen Erkrankungen führen können. Ziel der vorliegenden Arbeit war es daher, HPA-Achsen-regulierende kortikale Netzwerke mithilfe der funktionalen Magnetresonanztomographie (fMRT) in verschiedenen Versuchansätzen zu identifizieren.
Der Sta...2013-05-0800 min
Medizin - Open Access LMU - Teil 20/22Differential Expression of CRH, UCN, CRHR1 and CRHR2 in Eutopic and Ectopic Endometrium of Women with Endometriosis.Endometriosis is considered as a benign aseptic inflammatory disease, characterised by the presence of ectopic endometrium-like tissue. Its symptoms (mostly pain and infertility) are reported as constant stressors. Corticotropin releasing hormone (CRH) and urocortin (UCN) are neuropeptides, strongly related to stress and inflammation. The effects of CRH and UCN are mediated through CRHR1 and CRHR2 receptors which are implicated in several reproductive functions acting as inflammatory components. However, the involvement of these molecules to endometriosis remains unknown. The aim of this study was to examine the expression of CRHR1 and CRHR2 in endometriotic sites and to compare the expression of...2013-01-0100 minFakultät für Biologie - Digitale Hochschulschriften der LMU - Teil 05/06Central and peripheral aspects of hypothalamic-pituitary-adrenal (HPA) axis dysfunctionAn aberrant regulation of the hypothalamic-pituitary-adrenal (HPA) axis is closely associated with the pathophysiology of affective disorders such as major depression (MD). Accordingly, patients suffering from MD frequently show profound neuroendocrine alterations with hyper- or hypo-cortisolism as a result of a dysregulated stress hormone system. Focussing on this key endophenotype of MD, the ‘stress reactivity’ (SR) mouse model was recently established, consisting of three independent mouse lines, the high (HR), intermediate (IR) and low (LR) stress reactivity line, selectively bred for differences in their corticosterone (CORT) secretion in response to a psychological stressor. Previous studies revealed distinct differences between HR, IR a...2012-10-1700 minFakultät für Chemie und Pharmazie - Digitale Hochschulschriften der LMU - Teil 04/06Biomimetic screening of class B G protein-coupled receptorsDysregulation of the hypothalamic-pituitary-adrenal (HPA) axis is a hallmark of complex and multifactorial psychiatric diseases such as anxiety and mood disorders. The 41-amino acid neuropeptide Corticotropin Releasing Hormone (CRH) is a major regulator of the mammalian stress response. Upon stressful stimuli, it binds to the Corticotropin Releasing Hormone Receptor 1 (CRHR1), a typical member of the class B GPCRs and a potential novel target for the therapeutic intervention in major depressive disorder. A precise understanding of the peptide-receptor interactions is an essential prerequisite towards the development of efficient CRHR1 specific antagonists. To chemically probe the molecular interaction of CRH with its...2012-07-1200 minFakultät für Biologie - Digitale Hochschulschriften der LMU - Teil 04/06The involvement of central corticotropin-releasing hormone and its receptors in sleep-wake regulation of miceThe corticotropin-releasing hormone (CRH) is widely recognised as the major activator of the hypothalamic-pituitary-adrenocortical (HPA) axis, thereby mediating neuroendocrine, autonomic, and behavioural responses to stress. Dysregulation of the release of stress hormones, caused by excessive CRH secretion from the hypothalamus, is frequently observed in patients with affective disorders such as depression. One of the cardinal symptoms of major depression is a severe impairment of sleep (e.g. reduced sleep intensity, disinhibition of rapid eye movement sleep (REMS), and early morning awakenings). Consequently, besides a role of CRH in stress-induced arousal, its additional contribution to spontaneous sleep-wake regulation was suggested in...2010-07-1200 min
MPR: Jet StreamingJet Streaming for Wednesday, March 25The Red River of the North is on the rise and residents of Grand Forks, Fargo and beyond are stacking sandbags to fend back the waters. We get an update on the current flood status and what to expect in the days to come from Mark Ewens from the National Weather Service in Grand Forks. And the first-ever "State of the Birds" report has been issued by the U.S. Fish and Wildlife Service. Carrol Henderson of the Minnesota Department of Natural Resources stops by to tell us how our birds are measuring up. Dr. Mark Seeley brings us a...2009-03-2534 minMedizin - Open Access LMU - Teil 15/22The combined dexamethasone/CRH Test (DEX/CRH test) and prediction of acute treatment response in major depression.In this study the predictive value of the combined dexamethasone/CRH test (DEX/CRH test) for acute antidepressant response was investigated.
In 114 depressed inpatients suffering from unipolar or bipolar depression (sample 1) the DEX/CRH test was performed at admission and shortly before discharge. During their stay in the hospital patients received different antidepressant treatment regimens. At admission, the rate of nonsuppression (basal cortisol levels >75.3 nmol/l) was 24.6% and was not related to the later therapeutic response. Moreover, 45 out of 114 (39.5%) patients showed an enhancement of HPA axis function at discharge in spite of clinical improvement. In a second sample, 40 depressed patients...2009-01-0100 minFakultät für Biologie - Digitale Hochschulschriften der LMU - Teil 03/06Behavioral phenotyping, gene expression profiles, and cognitive aspects in a mouse model of trait anxietyAnxiety reflects a fundamental emotion, essential for survival. However, if it occurs unpredictably and exaggerated for a long period of time, it becomes pathological, confining a normal course of life. Anxiety disorders are among the most disabling psychiatric diseases, with increasing incidence. They are complex and occur as a combination of both, inherited and stress-related phenomena, whose origin and underlying mechanisms are still poorly understood. Besides clinical studies, extensive preclinical research is strongly focusing on the genetic, environmental, and developmental underpinnings of both, “physiological” and “pathological” anxiety.
Thus, in the year 2000, two mouse lines were generated by bi-directional selective inbreeding, reflecti...2008-06-0500 minMedizinische Fakultät - Digitale Hochschulschriften der LMU - Teil 08/19Der Dexamethason/Corticotropin-Releasing-Hormon-Test in der Verlaufsbeobachtung bei Patienten mit depressiver StörungDie depressive Störung gehört den affektiven Störungen, die durch eine krankhafte Veränderung der Stimmung (Affektivität) gekennzeichnet ist.
Die Punktprävalenz von Depressionen beträgt 5-10%. Das Lebenszeitrisiko an einer Depression zu erkranken beträgt ca. 15-17%. Unter den affektiven Störungen kommt den depressiven Erkrankungen bei weiten die größte Bedeutung zu. Sie gehören heute zu den häufigsten psychischen Erkrankungen. Nur 25% der Depressionen verlaufen einphasig, 75% der Erkrankungen rezidivieren. Bei unipolaren Depressionen muss im Mittel mit vier Episoden im Laufe eines Lebens gerechnet werden.
Als eine biologische Ursache für eine depressive Störung werden Dysregul...2008-04-2400 minMedizin - Open Access LMU - Teil 15/22Impact of Gene-Gender Effects of Adrenergic Polymorphisms on Hypothalamic-Pituitary-Adrenal Axis Activity in Depressed PatientsObjective: There is overwhelming evidence that activation of the hypothalamic-pituitary-adrenal (HPA) system plays a major role in depression and cardiovascular disease in genetically susceptible individuals. We hypothesized that due to the multiple interactions between the sympathetic and the HPA systems via adrenoceptors, polymorphisms in these genes could have an impact on HPA axis activity in major depression. Methods: Using the dexamethasone/corticotrophin-releasing hormone (DEX/CRH) test, we investigated the association of alpha 2-adrenoceptor (ADRA2A -1291C -> G) and the beta 2-adrenoceptor gene (ADRB2 Arg16Gly) in 189 patients with major depression during the acute state of the disease and...2008-01-0100 minMedizinische Fakultät - Digitale Hochschulschriften der LMU - Teil 07/19CRH-R1/2 vermittelte Effekte von Corticotropin-Releasing-Hormon (CRH) auf die Monozytenfunktion und Monozyten-Endothel-InteraktionNeben den klassischen kardiovaskulären Risikofaktoren wie arterielle Hypertonie oder Hypercholesterinämie kommen den psychosozialen Faktoren wie Stress oder Depression eine entscheidene Rolle als Risikofaktor für die Entwicklung der Atherosklerose zu. Obwohl das chronische Stresshormon Corticotropin-Releasing-Hormon im Rahmen der adaptiven Stressantwort als Hauptvertreter der Effektorhormone angesehen wird, sind die pathophysiologischen Mechanismen, die zu einer CRH/Stress-bedingten endothelialen Dysfunktion führen, weitgehend unbekannt. Diese Arbeit hatte zum Ziel, den Effekt von peripherem CRH auf die Monozyten/Endothel-Interaktion, beispielhaft die Adhäsion, herauszuarbeiten.
Die Untersuchungen der Monozyten-Endothel-Adhäsion wurde in einem in-vitro-Modell unter Verwendung der Zelllinien HMEC-1 und THP-1 mit einer neuen...2007-11-2900 minMedizinische Fakultät - Digitale Hochschulschriften der LMU - Teil 07/19Die CRH-Rezeptor-vermittelte Wirkung von CRH auf das GSH-GSSG-Redoxsystem von Endothelzellen2007-10-1100 minMedizinische Fakultät - Digitale Hochschulschriften der LMU - Teil 05/19Die Auswirkungen antidepressiver Therapieverfahren auf Verhalten und Regulation der Hypothalamus-Hypophysen-Nebennierenrinden-Achse im TiermodellIn der vorliegenden Dissertation untersuchten wir mit Hilfe des psychopathologischen Tiermodells der HAB- und LAB-Ratten, welche sich nicht nur bezüglich ihrer genetisch determinierten Emotionalität und ihrer Stressbewältigungsstrategien, sondern auch hinsichtlich der Reaktivität der HPA-Achse unterscheiden, Effekte des Serotonin-Wiederaufnahmehemmers Paroxetin und von rTMS auf Verhalten und die neuroendokrine Regulation.
Mit Hilfe des kombinierten DEX/CRH-Tests gelang es uns nachzuweisen, dass sich ein hohes Maß an angeborenem Angstverhalten in einer profunden Fehlregulation des Stresshormonsystems widerspiegelt. HAB-Tiere zeigten nach Verabreichung von Dexamethason einen verminderten Suppressionseffekt und die periphere Injektion von CRH führte zu einem deutlichen Anstieg der Plasmakonzentrationen von AC...2006-05-1100 minMedizin - Open Access LMU - Teil 14/22Monthly intravenous methylprednisolone in relapsing-remitting multiple sclerosis - reduction of enhancing lesions, T2 lesion volume and plasma prolactin concentrationsBackground: Intravenous methylprednisolone (IV-MP) is an established treatment for multiple sclerosis ( MS) relapses, accompanied by rapid, though transient reduction of gadolinium enhancing (Gd+) lesions on brain MRI. Intermittent IV-MP, alone or with immunomodulators, has been suggested but insufficiently studied as a strategy to prevent relapses. Methods: In an open, single-cross-over study, nine patients with relapsing-remitting MS (RR-MS) underwent cranial Gd-MRI once monthly for twelve months. From month six on, they received a single i.v.-infusion of 500 mg methylprednisolone ( and oral tapering for three days) after the MRI. Primary outcome measure was the mean number of Gd+ lesions during treatment...2006-01-0100 minMedizinische Fakultät - Digitale Hochschulschriften der LMU - Teil 04/19Untersuchungen zum Einfluss von Ghrelin auf das Schlaf-EEG und die assoziierte nächtliche Hormonaktivität bei gesunden ProbandenGhrelin ist der natürliche Ligand des wachstumshormon-sekretagogen (GHS)-Rezeptors (Kojima, 1999). Es stimuliert die Wachstumshormon (GH)-Ausschüttung an der Hypophyse und wirkt appetitsteigernd. Bisherige schlafendokrinologische Untersuchungen zeigen, dass die Hormone wachstumshormon-freisetzendes-Hormon (GHRH), Somatostatin, corticotropin-freisetzendes Hormon (CRH) und Cortisol in die Schlafregulation involviert sind. Auch synthetische Wachstumshormon-Sekretagoge (GHS) modulieren beim Menschen den Schlaf und beeinflussen die nächtliche hormonellen Sekretion. Ziel dieser Arbeit war es, die Effekte von Ghrelin auf das Schlaf-EEG und die nächtliche Hormonsekretion von GH, ACTH, Cortisol, Prolaktin und Leptin bei jungen gesunden Männern zu untersuchen. Nach Gabe von 4 x 50 µg Ghrelin iv. zu Beginn der Na...2005-06-0900 minMedizinische Fakultät - Digitale Hochschulschriften der LMU - Teil 02/19Sonic hedgehog signaling pathway in normal and adenomatous pituitaryThis work investigates for the first time the expression and the role of Sonic hedgehog signaling pathway in adult pituitary and in pituitary tumors. Shh is a signaling protein, important in regulating patterning and proliferation in the embryo and the adult. It has a crucial role in pituitary development and Shh deficient mice do not even have a rudimentary Rathke's pouch (the development structure that gives rise to anterior pituitary).
This study reveals the presence of an active Shh pathway in the post-developmental pituitary gland, with major impacts on hormone secretion and cell proliferation. After embryonic development, Shh continues to...2004-03-1800 minMedizin - Open Access LMU - Teil 10/22The hypothalamic-pituitary-adrenal axis in critical illnessPlasma ACTH and cortisol concentrations are frequently elevated in patients in intensive care units (ICU). To examine the functional integrity of the hypothalamic-pituitary-adrenal axis during critical illness, we evaluated prospectively 53 ICU patients in a general medical ICU. Thirty-one patients and 7 normal controls underwent an overnight dexamethasone suppression test (3 mg dexamethasone, orally, at 2300 h). Plasma ACTH and serum cortisol were measured at 0900 h. In a separate experiment, 22 patients and 7 control subjects underwent a CRH stimulation test [100 micrograms human (h) CRH, iv]. ACTH and cortisol concentrations were determined from -15 to 120 min. Compared to normal controls, plasma ACTH and serum cortisol concentrations...1993-01-0100 minMedizin - Open Access LMU - Teil 09/22Effects of loperamide on the human hypothalamo-pituitary-adrenal axis in vivo and in vitro.Loperamide, an opiate agonist of high specificity for p-receptors,
was recently reported to suppress ACTH and cortisol levels in normal
subjects, but not in patients with proven ACTH-dependent Cushing’s
disease. However, there is little information on the site of action of
loperamide in the hypothalamo-pituitary-adrenal axis of man. We
investigated the effect of loperamide on pituitary hormone secretion in
uiuo and in vitro. In seven normal subjects, basal ACTH plasma levels
were significantly suppressed 3 h after loperamide administration (16
mg, orally) from 5 + 1 to 2 f 0 pmol/L (P < 0.0001). After the combined
pituitary stimulation test (100 pg human CRH, 100 rg GnRH, 100 pg
GH-releasing ho...1992-01-0100 minMedizin - Open Access LMU - Teil 09/22Preclinical Cushing's syndrome in adrenal incidentalomasAdrenal tumors are usually diagnosed by clinical symptoms of hormone excess. The increasing use of ultrasound and computed tomography results in the detection of a substantial number of incidentally discovered adrenal tumors. Most of these tumors are nonfunctional adrenocortical adenomas, but a few cases of subclinical cortisol production in "incidentalomas" have been reported. We investigated prospectively the prevalence of autonomous cortisol production in 68 patients (44 females and 24 males, aged 25-90 yr) with adrenal incidentalomas at our institution. As a screening procedure all patients with incidentalomas underwent an overnight dexamethasone suppression test (1 mg). Patients who failed to suppress serum cortisol below 140 nmol...1992-01-0100 min