Shows
AMiNDR: A Month in Neurodegenerative Disease Research341 - Prevention & Intervention Strategies for ADNaila brings you 21 articles from January 2024, on non-pharmacological approaches to the prevention and intervention of Alzheimer's disease. You'll be treated to research from computational modeling, to rodent models, to clinical trials, with a particular focus on optimizing and personalizing intervention strategies. This episode also covers some research on the role of caregivers, and several papers consider the socioeconomic and ethnographic context in which these studies take place. Let's get to it! Stimulation Techniques (7)Exercise (3)Cognitive Training (2) Art Therapy and Dyad Interventions (4)Lifestyle Interventions and Prevention (5)...2024-04-0946 min
AMiNDR: A Month in Neurodegenerative Disease Research340 - Structure Neuroimaging in Alzheimer's Disease using AIJoin Christy for 12 papers from January 2024 on structural neuroimaging in the diagnosis of Alzheimer's disease. This episode is a bit different from past ones because it's all about the use of machine learning and deep learning. Whether you're an AI researcher or simply curious about the topic, you won't want to miss this episode. Detecting AD (3:42) Predictions, associations or comparisons (16:48)-------------------------------------------------------------- You can find the bibliography for this episode here, or by clicking the link below:https://drive.google.com/file/d/1KE4oVzsdER5iTuSqN9J5UMUk27S5w...2024-04-0231 min
AMiNDR: A Month in Neurodegenerative Disease Research339 - Treatments Targeting Neuroprotection in Alzheimer's DiseaseAnother series of AMiNDR kicks off with this episode. Anusha takes you through 7 papers published in January 2024 targeting neuroprotection in AD. If you'd like to hear about potential compounds that could reduce neurodegeneration in Alzheimer's disease, this is the episode for you.Testing for neuroprotection in cell lines (2:57)Testing for neuroprotection using in vivo AD models (11:47)-------------------------------------------------------------- You can find the bibliography for this episode here, or by clicking the link below:https://drive.google.com/file/d/1A4HZVCtgh5AwZkd5V2ATZSFAxGJt48q3/view?usp=drive_linkT...2024-03-2619 min
AMiNDR: A Month in Neurodegenerative Disease Research338 - Interview with Joseph Liang - Navigating The Journey To (And Through) Graduate SchoolAnother special episode to help kick off our return! In what we hope to be a recurring special series, an interview with members in our scholarly community on navigating the multiple facets of life as a scientist. In the first episode, host Kevin Nishimura interviews one of our own Joseph Liang on his personal journey to and through graduate school. Tune in to learn what he has to say about getting into graduate school, and how his perspective on the journey has changed since he's started! We hope you enjoy, and please let us know if you want to...2024-02-2024 min
AMiNDR: A Month in Neurodegenerative Disease Research337 - Prevention & Intervention Strategies for ADIn today's episode, Naila provides an overview of 14 articles published in November 2023 on non-pharmacological interventions for AD. You'll hear about cognitive training, music therapy, chair yoga, providing support to caregivers, and a range of neural stimulation techniques. Enjoy! Cognitive and Social Factors (2:26)Lifestyle interventions (13:40)Stimulation Techniques (19:20)-------------------------------------------------------------- You can find the bibliography for this episode here, or by clicking the link below:https://drive.google.com/file/d/1A4HZVCtgh5AwZkd5V2ATZSFAxGJt48q3/view?usp=drive_linkTo access the folder with AL...2024-02-1429 min
AMiNDR: A Month in Neurodegenerative Disease Research336 - Treatments Targeting Cholinergic Neurotransmission in ADJoin us as we cover a set of papers published in November 2023 on treatments targeting cholinergic transmission in Alzheimer's disease. In this episode hosted by Christy, we will go over various topics, from drug discovery using synthesized compounds to drug testing of plant extracts, as well as improving drug delivery through the blood-brain barrier. Enjoy! Papers evaluating synthesized compounds (2:00) Papers targeting AchE (10:45)-------------------------------------------------------------- You can find the bibliography for this episode here, or by clicking the link below:https://drive.google.com/file/d/1wh1EFtB3KrW0J6C...2024-02-0629 min
AMiNDR: A Month in Neurodegenerative Disease Research335 - A Conversation with Gina Martin: Bringing Visual Awareness to DementiaAs we get back up to speed on our regular episodes, we thought we'd treat you (and ourselves) to something out of the ordinary: a conversation on how visual storytelling can shape how we think - and feel - about Alzheimer's disease. Host Naila Kuhlmann had the pleasure of interviewing Gina Martin, who founded the Bob and Diane Fund to support and promote visual storytelling about Alzheimer's and dementia. Tune in to get the backstory on the fund, an auditory glimpse at the work of this year's winner, a discussion on the social narrative of Alzheimer's disease, and reflections...2024-01-2952 min
AMiNDR: A Month in Neurodegenerative Disease Research334 -Treatments Targeting Neuroprotection in Alzheimer's DiseaseHello listeners, it’s been a while since we last released an episode but we are back with another series here at AMiNDR bringing you a synopsis of publications on Alzheimer’s disease (AD) research on various topics that were released in November of 2023. In this episode, Anusha takes you through 11 papers testing potential neuroprotective agents for AD treatment. You’ll hear about naturally and pharmaceutically-derived compounds as well as strategies that exploit cell-endogenous processes for neuroprotection in AD. Testing Naturally-Derived Compounds for Neuroprotective effects (3:53)Testing Cell-Endogenous Mechanisms for Neuroprotection (16:57)Testing Pharmac...2024-01-2327 min
AMiNDR: A Month in Neurodegenerative Disease Research333 - Cognitive & Behavioural Changes in Alzheimer's Disease: February 2023If you’re interested in hearing about the impact of hearing aids on quality of life in AD patients, or how having a stable life partner can slow down the progression of dementia, tune in to this episode on the latest in cognitive and behavioural research in Alzheimer's disease! Judy will cover 9 papers on sleep, depressive symptoms and sensory processing, all published in February 2023. This is one you don't want to miss! Sections in this episode: Sleep (2:42) Depressive Symptoms (8:05) Sensory Processing (12:59) -------------------------------------------------------------- You can find the bibliography for this...2023-05-0819 min
AMiNDR: A Month in Neurodegenerative Disease Research332 - Prevention & Intervention Strategies for Alzheimer's Disease: February 2023In today's episode, Naila provides you with an overview of 10 paper published in February 2023, on non-pharmacological therapies for Alzheimer's disease. You'll learn about a virtual reality intervention targeting anxiety, the signaling pathways underlying the potential benefits of acupuncture, the challenges of implementing new interventions, and what spectral light flicker means. Happy listening! Sections in this episode: Psychological Interventions (1:37) Physical Activity (7:26) Neuromodulatory Techniques (14:05) -------------------------------------------------------------- You can find the bibliography for this episode here, or by clicking the link below:https://drive.google.com/file/d/1ZG-uORwCnfP383EN7-a2...2023-05-0327 min
AMiNDR: A Month in Neurodegenerative Disease Research331 - Treatments Targeting Neuroprotection in Alzheimer's Disease: February 2023This short and sweet episode kicks off the February 2023 series, highlighting studies all the way from worms to humans. Anusha will take you through 9 papers that converge on targeting neuroprotection in Alzheimer's disease. If you're interested in learning about implicated pathways or potential therapeutics, this episode is sure to whet your appetite. Sections in this episode: Targeting Specific Neuroprotective Pathways (3:39) Targeting Neuroprotection Broadly (13.21) -------------------------------------------------------------- You can find the bibliography for this episode here, or by clicking the link below:https://drive.google.com/file/d/1n7wQss1hiT-F...2023-05-0223 min
AMiNDR: A Month in Neurodegenerative Disease Research330 - Vascular Changes in Alzheimer's Disease: January 2023Elyn's back with more insight from the field on how blood vessel health impacts brain health. Tune in for a journey through mechanisms underlying increased risk from "vascular risk factors" like hypertension, diabetes, and atrial fibrillation, lots of neuroimaging studies providing clinical insights, and several interesting novel therapeutic avenues. If you weren't already convinced that the vasculature is relevant in the context of AD, you sure will be after this episode! Sections in this episode: Cerebral blood flow and hypoperfusion (4:08) More clinical insights (10:53) Blood-brain barrier and amyloid-endothelial cell interactions (19:52) Thera...2023-04-1140 min
AMiNDR: A Month in Neurodegenerative Disease Research329 - Treatments Targeting Neurotransmission in Alzheimer's Disease: January 2023This episode covers some papers from January 2023 on treatments focused on repairing the neurotransmitter imbalance in Alzheimer's disease. We hope you enjoy listening as Christy summarizes this exciting research—from the discovery of new therapeutics to the synthesis of drugs. Sections in this episode:Drug Screening (3:37)New Drugs (7:00)Synthesized Drugs (13:35)-------------------------------------------------------------- To find the numbered bibliography with all the papers covered in this episode, click here, or use the link below:https://drive.google.com/file/d/1BkF6ofShRYL_ggRRFKvNsHvBz4PrLfXr/view?usp=share_link2023-04-0722 min
AMiNDR: A Month in Neurodegenerative Disease Research328 - Functional Connectivity & Imaging in Alzheimer's Disease: January 2023In today’s episode of AMiNDR, Ellen will tell you all about the functional connectivity of different networks in the brain, and changes to brain structure and volume in Alzheimer’s disease. This includes how these changes in the brain relate to cognitive changes, behavioural symptoms, and other neuropathological markers. There are many fascinating studies to hear about today! Sections in this episode: Functional Connectivity (4:26) Excitation/Inhibition Balance & Neuronal Hyperactivity (17:48) Structural Changes (23:07) -------------------------------------------------------------- To find the numbered bibliography with all the papers covered in this episode, click here, or u...2023-04-0432 min
AMiNDR: A Month in Neurodegenerative Disease Research327 - Prevention & Intervention Strategies for Alzheimer's Disease: January 2023Naila covers 11 papers from January 2023, with a focus on a variety of stimulation techniques. You'll get a smattering of new research from humans to mice to flies, and from brain imaging to computer simulations to molecular mechanisms. Enjoy! Sections in this episode: Complementary therapies (2:55) Current and magnetic stimulation (7:25) Electroacupuncture (14:30) Other stimulation techniques (22:15) Other (25:52) -------------------------------------------------------------- To find the numbered bibliography with all the papers covered in this episode, click here, or use the link below:https://drive.google.com/file/d/15pdrQWDkOTA0XxP3flwu...2023-03-3030 min
AMiNDR: A Month in Neurodegenerative Disease Research326 - Cognitive & Behavioural Changes in Alzheimer's Disease: January 2023We’ve got a whole variety of studies in this January 2023 episode, spanning from sensory processing, to sleep, and even to depressive symptoms. Tune in to learn more about the latest in cognitive and behavioural changes in Alzheimer's disease! Sections in this episode: Sensory Processing (2:28) Sleep (7:30) Balance (14:14) Depression (17:00) Other (20:40) -------------------------------------------------------------- To find the numbered bibliography with all the papers covered in this episode, click here, or use the link below:https://drive.google.com/file/d/12xQGoq0NZituFfenbI_RDmBMaTSSaJIw/view?usp=share_link...2023-03-2925 min
AMiNDR: A Month in Neurodegenerative Disease Research325 - Treatments Targeting Neuroprotection in Alzheimer's Disease: January 2023In this episode, we’ll be covering papers that were released in January 2023 that target neuronal and synaptic protection in Alzheimer’s Disease. If you’re interested in the preclinical testing of novel therapeutics and delivery methods, this is the episode for you! Sections in this episode: Novel Therapeutics Targeting Neuroprotection (4:53) Novel Delivery Methods Targeting Neuroprotection (8:49) Targeting Synaptic Pathology (16:42) Targeting BDNF Activation (23:18) We at AMiNDR are eager to hear from you! We opened up a survey available until the end of April for you to tell us what we are...2023-03-2339 min
AMiNDR: A Month in Neurodegenerative Disease Research316 - Treatments Targeting Neuroprotection in Alzheimer's Disease: October 2022Anusha brings you another episode of AMiNDR featuring literature published in October 2022. In this episode, you'll hear 12 papers that converge on the topic of treatments that target neurotoxicity. This episode is poised to leave you feeling hopeful about the various treatment avenues to be pursued so be sure to tune in! Sections in this episode: Targeting Neurotoxicity in vitro (3:53) Invertebrate models of AD (8:41) Transgenic AD models (14:48) Other AD models (22:47) -------------------------------------------------------------- To find the numbered bibliography with all the papers covered in this episode, click here, or use...2023-01-2431 min
AMiNDR: A Month in Neurodegenerative Disease Research311 - Understanding APOE: August 2022In this month's episode of AMiNDR, Cassi recaps papers on APOE published in August 2022. Cassi just defended her dissertation where she studied immunometabolism in the context of APOE. She starts with cells, moves to mice, and finishes with human research studies. -------------------------------------------------------------- To find the numbered bibliography with all the papers covered in this episode, click here, or use the link below:https://drive.google.com/file/d/11pGVGJGUWfPNAqJ-Jw7cUGyUGb_HRXwy/view?usp=drivesdkTo access the folder with ALL our bibliographies, follow this link (it will be updated as we pu...2022-12-2228 min
AMiNDR: A Month in Neurodegenerative Disease Research302 - Vascular Changes in Alzheimer's Disease: July 2022Elyn is back to discuss the latest research on vascular contributions to Alzheimer disease! Tune in to hear about proteomic changes with amyloid deposition in the vasculature, new therapeutic avenues, and a more detailed account of the perivascular space. If you're interested in factors beyond amyloid and tau in the Alzheimer disease pathology, this is a great place to start! Sections in this episode: Cardiovascular Risk Factors (3:45) White Matter Hyperintensities (8:51) Cerebral Amyloid Angiopathy and the Blood-Brain Barrier (15:47) Therapeutic Avenues (24:00) -------------------------------------------------------------- To find the numbered bibliography with al...2022-10-1329 min
AMiNDR: A Month in Neurodegenerative Disease Research301 - Synaptic Transmission in Alzheimer's Disease: July 2022We are kicking off our July 2022 series of AMiNDR with this episode and are so glad you are tuning in. If you’re interested in changes to neuronal function in AD, we’ll be covering the entire spectrum in this episode. Starting big with network changes, we scale all the way down to molecular changes that may underlie AD pathology, so if that’s what you’re interested in, stay tuned! Sections in this episode: Special Mention of Blots in a Field? (3:39) Network Dysfunction (4:53) Synaptic Dysfunction (12:09) Molecular Changes (22:33) ...2022-10-1230 min
AMiNDR: A Month in Neurodegenerative Disease Research291 - Vascular Contributions to Alzheimer's Disease: May 2022Elyn is back with a short and sweet episode on the latest research on vascular contributions to Alzheimer disease! Tune in for a quick recap of May 2022 research, and a disease perspective a bit more lively than the classic amyloid cascade hypothesis! Clinical Studies (3:53)Preclinical Studies/Methology (12:41) -------------------------------------------------------------- To find the numbered bibliography with all the papers covered in this episode, click here, or use the link below: https://drive.google.com/file/d/1ykvbecZO_b3jUyCRc-LG6hgj2ORitxKT/view?usp=sharin...2022-08-0120 min
AMiNDR: A Month in Neurodegenerative Disease Research286 - Synaptic Transmission in Alzheimer's Disease: May 2022AMiNDR is back and excited to bring you more literature on Alzheimer’s Disease. In this episode, we’ve got papers published in May of 2022 on the subject of changes to synaptic transmission and neuronal excitability. Anusha covers subjects like calcium homeostasis, synaptic function, and how to translate findings to humans and human models, so join her if your neurons are excited by the topic! Sections in this episode: Calcium Homeostasis (2:54) Synaptic Function in Animal Models (5:26) Human Models (10:28) -------------------------------------------------------------- To find the numbered bibliograph...2022-07-2016 min
AMiNDR: A Month in Neurodegenerative Disease Research278 - Risk Factors for Alzheimer's Disease Part 1: February 2022In today's episode, Naila will guide you through 19 papers from February 2022 on the prevalence and incidence of Alzheimer's disease in various study populations, social determinants of health, as well as environmental and lifestyle factors that may influence the risk of dementia. Part 2 will be available as a bibliography, which you can find in our show notes or at www.amindr.com! Sections in this episode: Epidemiological Studies (1:56) Racial/Ethnic Disparities (11:50) Social Determinants (25:24) Lifestyle and Environmental Factors (31:44) -------------------------------------------------------------- To find the numbered bibliography with all the papers...2022-04-2642 min
AMiNDR: A Month in Neurodegenerative Disease Research267 - Synaptic Transmission in Alzheimer's Disease: January 2022We start off our January 2022 series of AMiNDR with this episode highlighting 9 papers on changes to synaptic transmission in Alzheimer's Disease. In this episode, Anusha will cover topics including changes to GABAergic and glutamatergic transmission and calcium flux in AD-affected neurons. We also have papers looking at age-dependent changes in synaptic function in AD. End neuro-transmission ;) Sections in this episode: Changes to GABAergic transmission (2.41) Changes to calcium flux (6.42) Changes to glutamateric transmission (8.38) Age-dependent changes in AD (13.11) -------------------------------------------------------------- To find the numbered bibliography with all the papers...2022-03-1421 min
AMiNDR: A Month in Neurodegenerative Disease Research261 - Clinical Assessment in Alzheimer's Disease Part 2: December 2021This episode of AMiNDR is part 2 of our Clinical Assessment series. Today, you'll hear about new cognitive tests and advancements in existing tools for clinical testing. With every new study on Alzheimer’s disease, we are one step closer to understanding this disease better, diagnosing people faster, and helping people more effectively. Get ready to hear about some of the latest ways that scientists and clinicians are getting us closer to these goals! Sections in this episode: New or Updated Assessment Tools (4:56) Evaluating Existing Tools (12:50) Cognition in Specific Populations (17:18) ...2022-02-1923 min
AMiNDR: A Month in Neurodegenerative Disease ResearchSPECIAL: Lessons from Grad School with Neuropsyched MagazineIn this special episode of AMiNDR, where we sit down with Jenn Kim and Lucy Aceves, two of the creators of the graduate student-run Neuropsyched Magazine! We talk all things graduate school and academia -- from useful tips for choosing a PI, our experiences of grad school during the pandemic, financial barriers we have faced, and establishing boundaries. We also tell you about Neuropsyched magazine, and what working in science communication means to all of us! This conversation was a blast to have and we think you'll have a blast listening to it too, no matter where you are i...2022-01-181h 23
AMiNDR: A Month in Neurodegenerative Disease Research237 - Tau Protein Pathology in Alzheimer's Disease: October 2021Kate lets you know what's going on in the world of tau protein research in this episode of AMiNDR! Tune in to hear all about tau seeding, tau pathology, and potential therapeutic interventions for Alzheimer's Disease that target this protein. Enjoy! Sections in this episode: Tau seeding-related pathology (3:40) Targeting tau for therapeutic interventions in AD (14:35) -------------------------------------------------------------- You can find the numbered bibliography for this episode by clicking here, or the link below:https://drive.google.com/file/d/1-KRBJQRI7Z9e0EjmqqlZUPYHv34rkUlU/view?usp=sharingTo...2021-12-1620 min
AMiNDR: A Month in Neurodegenerative Disease Research236 - Detecting Amyloid, Tau & New Markers in the Brain: October 2021To kick off our series on papers published in October 2021, we'll look at 7 papers that rely on Positron Emission Tomography (or PET) imaging to detect amyloid and tau pathology in the brain, within the context of Alzheimer's disease! If you're interested in learning about tau and amyloid based detection, alternative PET tracers in AD research, or combining PET with different imaging modalities, make sure to tune into this episode. Sections in this episode: Amyloid Detection (2:35) Tau Detection (7:40) Amyloid + Tau (10:41) Miscellaneous (12:34) -------------------------------------------------------------- To access the folder with al...2021-12-1315 min
AMiNDR: A Month in Neurodegenerative Disease Research232 - Prevention & Intervention Strategies for Alzheimer's Disease : September 2021This episode is short and sweet, covering 7 papers on cognitive training, exercise and stimulation techniques. Naila will guide you through the latest in animal models and underlying mechanisms for these potential non-pharmacological interventions. Sections in this episode:Cognitive Training (2:06) Exercise (4:23) Stimulation Techniques (11:38)-------------------------------------------------------------- You can find the numbered bibliography for this episode by clicking here, or the link below:https://drive.google.com/file/d/1PjokO3cFgLOjtRyi9yjQlckHRNKMtiEM/view?usp=sharingTo access the folder with all the bibliographies for 2021 so far, follo...2021-12-0417 min
AMiNDR: A Month in Neurodegenerative Disease Research229 - Risk Factors for Alzheimer's Disease Part 1: September 2021In today's episode, Naila takes you through 10 papers on risk factors associated with Mild Cognitive Impairment, Alzheimer's and dementia. You'll hear a little on lifestyle factors, air and noise pollutants, and hormones. Stay tuned for Part 2! Sections in this episode: Lifestyle & Environmental Factors (2:09) Hormones (15:13) -------------------------------------------------------------- You can find the numbered bibliography for this episode by clicking here, or the link below:https://drive.google.com/file/d/1BUfTeMbAC0HzYcXRieJSQdsoNKS9r2J7/view?usp=sharingTo access the folder with all the bibliographies for 2021 so far, follo...2021-11-2721 min
AMiNDR: A Month in Neurodegenerative Disease Research219 - Clinical Markers of Alzheimer's Disease Part 1: August 2021Do you want to brush up on your knowledge of MoCA, ADAS-Cog, the MMSE and other cognitive tests? Join Sarah to hear about the 7 papers published in August 2021 where we’re evaluating existing tests for their specificity and sensitivity in detecting Alzheimer's disease and mild cognitive impairment. -------------------------------------------------------------- You can find the numbered bibliography for this episode by clicking here, or the link below:https://drive.google.com/file/d/1w5W2UPrmR7vRgFtjsWj4KBMXh3qhFHoN/view?usp=sharingTo access the folder with all the bibliographies for 2021 so fa...2021-11-0228 min
AMiNDR: A Month in Neurodegenerative Disease Research218 - Cognitive and Behavioural Changes in Alzheimer's Disease: August 2021In today's episode of AMiNDR, we’ll be talking about the latest work on cognitive and behavioural changes in Alzheimer's Disease, including papers on executive functioning, depression, social impairments, motor coordination, and more. Join Ellen as she guides you through 18 papers on the mechanisms behind cognition and other neuropsychological symptoms in AD! Sections in this episode: Cognitive Profiles (4:07) Executive Functions (13:06) Exercise & Cognition (18:12) Psychiatric & Social Symptoms (21:54) Motor Coordination & Balance (34:09) Sleep & Circadian Rhythms (35:52) -------------------------------------------------------------- You can find the numbered bibliography for this epi...2021-10-3041 min
AMiNDR: A Month in Neurodegenerative Disease Research215 - Treatments Targeting Mitochondria & Metabolism: August 2021Join Marcia as she explores the what’s, how’s, and why’s of all things oxidative stress, mitochondrial dysfunction and metabolism in AD. With this month’s - August 2021- papers, you’ll hear about the latest related cell and animal model studies, AD-adjunct diabetes, and even about potential therapeutics! So sit back and enjoy! Sections in this episode: Metabolism (2.40) Oxidative Stress (11.02) Mitochondrial Dysfunction (22.25) -------------------------------------------------------------- You can find the numbered bibliography for this episode by clicking here, or the link below:https://drive.goog...2021-10-2333 min
AMiNDR: A Month in Neurodegenerative Disease Research210 - Tau Protein Pathology in Alzheimer's Disease: August 2021Today, Kate will be focusing on everything tau-related in 12 papers published in August 2021, including aspects of tau pathology and exploring potential therapeutics targeting tau in Alzheimer’s disease! Sections in this episode:Tau Aggregation & Post-Translational Modifications (PTMs) (3.16)Tau Pathology & Seeding (13.30)Targeting Tau for Treatment (20.10)-------------------------------------------------------------- You can find the numbered bibliography for this episode by clicking here, or the link below:https://drive.google.com/file/d/1IIilzUhWAF_WuBM4trkcW12daiB52sT2/view?usp=sharingTo access the folder with all the...2021-10-1229 min
AMiNDR: A Month in Neurodegenerative Disease Research208 - Prevention & Intervention Strategies in Alzheimer's Disease: August 2021In this short and sweet episode, Naila covers 7 new papers on prevention and intervention of Alzheimer's disease. You'll hear about upcoming clinical trials of behavioural and cognitive interventions, a little bit about the mechanisms underlying the therapeutic effects of exercise, and about non-invasive stimulation techniques for treating AD. Sections in this episode: Cognitive / Physical Training (1:57) Neuromodulatory Techniques (9:27) -------------------------------------------------------------- You can find the numbered bibliography for this episode by clicking here, or the link below:https://drive.google.com/file/d/1W9coBE5hJ7I8Np...2021-10-0717 min
AMiNDR: A Month in Neurodegenerative Disease Research207 - Treatments targeting neuroprotection & synaptic activity in Alzheimer's Disease: August 2021Another month passed means another month of literature for AMiNDR to bring to you! This time, Anusha will be highlighting papers from August of 2021 that are about treatments targeting neuroprotection and synaptic activity in Alzheimer's disease. Beginning with computation and cuvettes and ending with clinical trials, we have 15 papers for your perusal so check out this episode if this topic tickles your fancy. Sections in this episode: Drug discovery and testing in vitro (2.26) Testing potential compounds in AD models (7.06) Phase II Clinical Trials (21.42) -------------------------------------------------------------- You can...2021-10-0526 min
AMiNDR: A Month in Neurodegenerative Disease Research202 - Tau protein pathology in Alzheimer's Disease: July 2021Kate brings you the latest research on tau pathology in Alzheimer's Disease. This includes post-translational modifications, tau aggregation and seeding, and targeting tau in treatment development. Enjoy! Sections in this episode: Tau Pathology (4:35) Post-translational modifications (4:56) Tau aggregation and seeding behaviour (16:30) Targeting Tau for Treatment Development (21:09) -------------------------------------------------------------- You can find the numbered bibliography for this episode by clicking here, or the link below:https://drive.google.com/file/d/1xBMvUdqdBPnGQDnv9qBk9icbKBNEbdXZ/view?usp=sharingTo access the folde...2021-09-1626 min
AMiNDR: A Month in Neurodegenerative Disease Research199 - Treatments targeting neuroprotection in Alzheimer's Disease: July 2021Animal and cell models of Alzheimer's Disease are featured in this episode that covers potential therapeutics that target neuroprotection. We have 5 papers that focus broadly on the subject and 10 more that delve into mechanisms of action of these compounds so join Anusha as she highlights July of 2021's publications on the topic! Sections in this episode: Treatments targeting neuroprotection (1.03) Mechanism of treatments targeting neuroprotection (11.14) -------------------------------------------------------------- You can find the numbered bibliography for this episode by clicking here, or the link below:https://drive.g...2021-09-1026 min
AMiNDR: A Month in Neurodegenerative Disease Research198 - Understanding Cognitive & Behavioural Changes in Alzheimer's Disease: July 2021Visual reaction time, japanese orange scent, language, psychosis, and insomnia are just some of the topics you’ll hear about today in this episode. Have we piqued your interest? Today Ellen tells you about the latest papers on the mechanisms of, and treatments for, cognitive and behavioural changes in Alzheimer's Disease. Enjoy the show! Sections in this episode: Sensory processing & function (3:31) Speech (9:16) Learning & memory (11:17) Psychiatric changes (13:50) Sleep (21:20) -------------------------------------------------------------- You can find the numbered bibliography for this episode by clicking here, or the link below:...2021-09-1031 min
AMiNDR: A Month in Neurodegenerative Disease Research196 - Changes to Gene Expression in Alzheimer's Disease: July 2021“Omics”, “differential expression” and “biomarker discovery” – Are these phrases you commonly use in your research? Or have you come across them and wondered what they meant in the context of AD? If you're nodding your head at either of those, this episode is just for you. Join Marcia as she brings you the latest research published in July 2021 on ‘RNA, Transcription and translation in AD’! Sections in this episode: Gene expression and transcriptomics (02:26) Proteomics (17:38) -------------------------------------------------------------- You can find the numbered bibliography for this episode by clicking here, or the link below...2021-09-0725 min
AMiNDR: A Month in Neurodegenerative Disease Research194 - Treatments targeting Neurotransmitter Imbalances: June 2021In this episode, Anusha will guide you through 20 papers that tackle acetylcholine and glutamate imbalances in Alzheimer's Disease. These papers were published in June of 2021 and address topics like inhibiting cholinesterases and NMDA receptors. We hope this information transmits to your neurons! Sections in this episode: Novel Anti-Cholinesterase Drugs (2.39) Existing Anti-Cholinesterase Drugs (16.28) Targeting Glutamate (26.17) -------------------------------------------------------------- To access the folder with all the bibliographies for 2021 so far, follow this link (it will be updated as we publish episodes and process bibliographies), or click the following link below:http...2021-08-1930 min
AMiNDR: A Month in Neurodegenerative Disease Research193 - Clinical Markers of Alzheimer's Disease: June 2021In this episode, Maria will be going over 17 papers published in June 2021 on Clinical Indicators of Alzheimer's diseaes and mild cognitive impairment. Topics covered will include the use of technology to assess cognition, semantic memory, cognitive tests, behavioural tests, oculomotor tests, and language adaptations. If you're interested in new ways of detecting AD, make sure you tune in! Sections in this episode:Technology for AD and MCI (2:08) Semantic Memory(8:11) Test for Aspects of Cognition (11:38) Oculomotor Markers of Cognition (20:50) Language Adaptations (23:03)-------------------------------------------------------------- Click...2021-08-1829 min
AMiNDR: A Month in Neurodegenerative Disease Research192 - Risk Factors for Alzheimer's Disease: June 2021Naila has 23 papers for you today, that will provide you with an overview of epidemiological research published in June 2021. You'll hear about the incidence and prevalence of AD in specific populations, sociodemographic and health conditions that increase the risk of dementia and AD, and about a few potentially neuroprotective factors as well. Enjoy! Sections in this episode: Prevalence, incidence, multiple factors (2:08) Cardiovascular (20:33) Other health conditions (25:30) Protective (40:52) -------------------------------------------------------------- To access the folder with all the bibliographies for 2021 so far, follow this link (it will be updat...2021-08-1748 min
AMiNDR: A Month in Neurodegenerative Disease Research191 - Detection of Amyloid, Tau and new PET targets in Alzheimer's Disease: June 2021Here, we'll be taking a closer look at 14 papers published in June 2021 that rely on Positron emission tomography imaging (or PET) to detect amyloid and tau pathology in the brain, within the context of Alzheimer's disease! If you're interested in learning about tau and amyloid based detection, alternative PET tracers in AD research, or combining PET with different imaging modalities, make sure to tune it. Sections in this episode: Amyloid-beta based detection (1:30)Tau based detection (9:45)Amyloid-beta and tau (15:04)Case studies (16:48)Other PET targets (19:01)...2021-08-1322 min
AMiNDR: A Month in Neurodegenerative Disease Research190 - Brain Connectivity Changes in Alzheimer's Disease: June 2021Interested in brain connectivity changes specific to Alzheimer's disease? Come join us as Judy presents 13 papers featuring fMRI, machine learning and other brain mapping techniques that explore functional connectivity in AD. You're sure to learn something new! Sections in this episode: fMRI (01:32) Machine Learning (12:10) Other (14:36) -------------------------------------------------------------- You can find the numbered bibliography for this episode by clicking here, or the link below:https://drive.google.com/file/d/1qQcxhvhiOUvDSfqcLh4FbI43oFEEelrm/view?usp=sharingTo access the folder with all the bib...2021-08-1320 min
AMiNDR: A Month in Neurodegenerative Disease Research188 - APP processing & Amyloid-beta aggregation in Alzheimer's Disease: June 2021Only 14 papers published on APP processing and Amyloid-beta aggregation in the month of June, what’s going on? Well, it is still our pleasure to give you brief summaries on the matter, so if you research Alzheimer’s disease, you do want to tune in for your monthly update on secretase activity, seeding of misfolding, metal ion content of aggregates, and amyloid-beta toxicity. Sections in this episode: APP Processing & Secretases (3.15) Characterizing Aggregate Content (7.00) Amyloid-β Aggregation (10.09) Downstream effects of Amyloid-β (25.16) -------------------------------------------------------------- To access the folder with all the bibli...2021-08-1130 min
AMiNDR: A Month in Neurodegenerative Disease Research187 - Prevention & Intervention Strategies for Alzheimer's Disease: June 2021In this short and sweet episode, Naila covers 12 papers from June 2021 regarding non-pharmacological strategies to prevent or intervene in dementia progression. You'll hear about a few exercise programs, some creative ways to improve quality of life for people with dementia and caregivers, and a range of neuromodulatory (stimulation) techniques. Sections in this episode: Exercise (1:37) Multidomain / Other (7:05) Neuromodulatory Techniques (15:20) -------------------------------------------------------------- You can find the numbered bibliography for this episode by clicking here, or the link below:https://drive.google.com/file/d/1y6rZuX5vL...2021-08-1027 min
AMiNDR: A Month in Neurodegenerative Disease Research186 - Treatments targeting neuronal protection in Alzheimer's Disease: June 2021Join our host Anusha as she takes you through papers published in June of 2021 that target neuroprotection as a potential treatment avenue for Alzheimer's disease. Half these papers use amyloid-beta induced models of Alzheimer's disease so be sure to check it out if neuroprotection is up your alley. Sections in this episode: Treatments targeting neuroprotection in amyloid-beta induced AD models (2.03) Neuroprotection in other AD models (12.51) -------------------------------------------------------------- You can find the numbered bibliography for this episode by clicking here, or the link below:https://drive.google.com/file/d...2021-08-0724 min
AMiNDR: A Month in Neurodegenerative Disease Research185 - Metabolic Changes, Hemodynamics and EEG in Alzheimer's Disease: June 2021In this shorter episode, Judy goes over papers published in June 2021 that focus on diagnostic tools of Alzheimer's disease. Topics include metabolic changes, hemodynamics and EEG biomarkers. Listen in to find out more! Sections in this episode: Metabolic changes in AD (1:20) Hemodynamics (9:30) EEG (13:30) -------------------------------------------------------------- You can find the numbered bibliography for this episode by clicking here, or the link below:https://drive.google.com/file/d/1lzkStThvq02V_tpeuqBDfmZuLlhg6RwQ/view?usp=sharingTo access the folder with all the bibliog...2021-08-0618 min
AMiNDR: A Month in Neurodegenerative Disease Research183 - Changes to Gene Expression in Alzheimer's Disease: June 2021We know how critical gene expression and its regulation is to cellular homeostasis. In light of that, it is imperative that we discuss the possibility that Alzheimer’s disease could be caused by disturbances in DNA methylation in certain genes and the potential role of methylation in being a biomarker in AD. In today's episode, Marcia brings you the latest research on this topic, summarizing 9 papers from June 2021. Sections in this episode: Transcription and differential gene expression (02:12) Methylation (09:56) Multiomics (13:29) -------------------------------------------------------------- You can find the numbered bibliography for this epi...2021-08-0418 min
AMiNDR: A Month in Neurodegenerative Disease Research181 - Clinical Markers of Alzheimer's Disease Part 2: May 2021From standard clinical testing to motor assessments such as gait performance and handwriting ability, Judy will cover 10 papers on various types of markers in Alzheimer's Disease. Tune in for our final May 2021 episode and learn something new about the different techniques used in AD diagnosis! Sections in this episode: Clinical Testing (1:58) Motor Assessments (7:39) Semantic Dementia (11:28) Sleep (14:03) -------------------------------------------------------------- You can find the numbered bibliography for this episode by clicking here, or the link below:https://drive.google.com/file/d/1pKecrNPbkMwJyc_z7Yeo3P0...2021-07-1518 min
AMiNDR: A Month in Neurodegenerative Disease Research180 - Clinical Markers of Alzheimer's Disease Part 1: May 2021In this episode, Maria goes over 22 papers from May 2021 on various cognitive tests for Alzheimer's disease and mild cognitive impairment. Paper topics include tests of general cognition, visual, verbal and auditory tests, dementia subtypes, machine learning, and language and culturally adapted tests. Sections in this episode: General cognition (2:00) Visual, verbal, and auditory testing (13:50) Other dementia subtypes (18:43) Machine learning (25.08)Language and cultural adaptations (29.32)-------------------------------------------------------------- To access the folder with all the bibliographies for 2021 so far, follow this link (it will be updated as we p...2021-07-1433 min
AMiNDR: A Month in Neurodegenerative Disease Research179 - Treatments targeting the Immune System & Glial Cells in Alzheimer's Disease: May 2021Abdullah takes you through papers from May 2021 on treatments to target the immune system and glial cells to treat Alzheimer's Disease. This includes things like coconut looking funguses and olive oil. These are just a few of the treatments being covered in this episode, tune in to find out more! Sections in this episode: Inflammasomes (3:31) Effects on Neuroinflammation (9:17) Miscellaneous Papers (24:20) -------------------------------------------------------------- To access the folder with all the bibliographies for 2021 so far, follow this link (it will be updated as we publish episodes and process...2021-07-1335 min
AMiNDR: A Month in Neurodegenerative Disease Research178 - Amyloid-Beta Pathology in Alzheimer's Disease: May 2021In the second part of our episodes on amyloid-beta, we focus on the ways abeta contributes to AD pathology. This ranges from its effects on the hippocampus and memory, to more mechanistic studies on ion homeostasis, lipid membrane integrity, and prion-like seeding, without forgetting our friend tau! Tune in for an episode as eventful as an episode of Game of Thrones where amyloid-beta wages a war on the good people of Westeros…or...wages a war on neurons. Enjoy! Sections in this episode: Amyloid-beta toxicity: (9:05) Iron Dyshomeostasis: (18:13) Prion-Like Seeding & Spread: (24:19) Miscel...2021-07-1038 min
AMiNDR: A Month in Neurodegenerative Disease Research177 - Treatments targeting Neurotransmitter Balance in Alzheimer's Disease: May 2021This episode of AMiNDR highlights literature published in May of 2021 that target neurotransmitter balance in Alzheimer's Disease. Greatest hits include cholinesterase inhibition, targeting glutamate excitotoxicity, and there's even a bonus paper on adrenergic transmission. Get excited! But maintain homeostasis. Sections in this episode: Targeting cholinesterases and oxidative stress (1.56) Targeting glutamate and excitotoxicity (22.33) Targeting Adrenergic Receptor (26.58) -------------------------------------------------------------- To access the folder with all the bibliographies for 2021 so far, follow this link (it will be updated as we publish episodes and process bibliographies), or click the following link be...2021-07-0930 min
AMiNDR: A Month in Neurodegenerative Disease Research176 - Familial Mutations, New Variants & Other Genetic Insights in Alzheimer's Disease: May 2021Wow - May 2021 is a productive month for AD genetics research! Tune in and Joseph will take you through 19 papers on studies to do with new variants, novel genetic insights, or studies on familial AD genetics. Sections in this episode: Methods for Gene and Pathway Discovery (1:46) GWAS, Transcriptome, Exome Sequencing (5:47) Miscellaneous (12:55) Familial AD (17:11) -------------------------------------------------------------- You can find the numbered bibliography for this episode by clicking here, or the link below:https://drive.google.com/file/d/1pKecrNPbkMwJyc_z7Yeo3P0frV...2021-07-0832 min
AMiNDR: A Month in Neurodegenerative Disease Research175 - Role of the Immune System & Glial Cells in Alzheimer's Disease: May 2021In this episode, Courtney takes you through the papers from May of 2021 on the Role of Immune systems and glial cells in Alzheimer's disease pathology! We will be discussing papers related to neuroinflammatory pathways in microglia and astrocytes, metabolism, peripheral inflammation and so much more! Tune in for this exciting episode! Sections in this episode: Microglia (02:07) Astrocytes (10:42) TREM2 (13:34) Metabolism (18:08) Periphery (24:53) -------------------------------------------------------------- You can find the numbered bibliography for this episode by clicking here, or the link below:https://drive.google.com/file/d/1...2021-07-0633 min
AMiNDR: A Month in Neurodegenerative Disease Research174 - Understanding Cognitive & Behavioural Changes in Alzheimer's Disease Part 2: May 2021In part 2 of this set of episodes, Ellen dives into papers on psychiatric changes and sleep disturbances in the context of AD. This includes research looking at depression, anxiety, agitation, circadian rhythm, and more in AD patients, animal models, and even clinical trials! There's sure to be something for everyone in this diverse set of papers, enjoy! Sections in this episode: Depression (2:27) Anxiety (5:26) Stress & PTSD (9:55) Agitation (13:30) Emotional Reactivity (17:13) Sleep & Circadian Rhythms (19:12) -------------------------------------------------------------- You can find the numbered bibliography for this episode by clicking...2021-07-0633 min
AMiNDR: A Month in Neurodegenerative Disease Research173 - APP Processing & Amyloid-Beta Aggregation in Alzheimer's Disease: May 2021Hello hello to fellow baptists, tauists and all protein aggregation enthusiasts! Sarah brings you 15 papers from the month of May on Amyloid-beta aggregation! This is the first part of a 2 episode series on understanding the role amyoid-beta plays in Alzheimer’s disease pathology, and you will hear about APP processing and localization, then amyloid-beta generation and aggregation. We will also throw a teaser on Amyloid-beta detection with a focus on plaques, so stay tuned if you need an update far from the screen while enjoying a walk, transiting to work, or going about your house chores.Are yo...2021-07-0339 min
AMiNDR: A Month in Neurodegenerative Disease Research172 - Detection of Amyloid, Tau, and other PET Targets in Alzheimer's Disease: May 2021In this episode, we’ll take a closer look at 13 papers published in May 2021, that rely on Positron emission tomography imaging (or PET) to detect amyloid and tau pathology in the brain, within the context of Alzheimer’s disease! Make sure to take a listen if you’re interested in learning more about tau and amyloid based detection, alternative PET tracers in AD research, or combining PET with different imaging modalities. Sections in this episode: Tau Based Detection (1:48) A-beta Based Detection (10:45) Tau and A-beta (18:10) Other PET Targets (19:33) ...2021-07-0222 min
AMiNDR: A Month in Neurodegenerative Disease Research171 - Understanding Cognitive & Behavioural Changes in Alzheimer's Disease Part 1: May 2021In part one of this 2-parter, Ellen will tell you all about the latest studies on cognition and motor deficits in AD. This includes mechanistic studies, as well as studies looking at potential treatment avenues for these symptoms. We hope you enjoy, and stay tuned for part 2 coming out soon! Sections in this episode: Cognition in AD patients (4:09) Cognition in animal models (9:38) Motor impairments (19:00) ------------------------------------------------------------- PLEASE FILL OUR SURVEY TO HELP US IMPROVE OUR PODCAST, AND ENTER A DRAW FOR A $30 GIFT CARD. Link if you prefer...2021-07-0124 min
AMiNDR: A Month in Neurodegenerative Disease Research170 - Hemodynamics, Metabolic Changes & EEG in Alzheimer's Disease: May 2021From working memory tasks to mouse models, and even to lexical semantics, Judy goes over a wide range of papers that study AD diagnosis using a variety of neuroimaging techniques. Check out this episode if you're interested in hearing about changes in cerebral blood flow, metabolism and EEG signals in the context of AD. You're sure to learn something new! Sections in this episode: Hemodynamics (1:05) Metabolic Changes (9:45) EEG (16:30) ------------------------------------------------------------- PLEASE FILL OUR SURVEY TO HELP US IMPROVE OUR PODCAST, AND ENTER A DRAW FOR A $30 GIFT CARD. Link...2021-06-3024 min
AMiNDR: A Month in Neurodegenerative Disease Research169 - Treatments targeting Neuroprotection and Synaptic Activity in Alzheimer's Disease: May 2021Anusha will guide you through 21 papers in this episode that target synaptic and neuroprotection as therapeutic intervention for Alzheimer's disease. She covers 3 topics including the use of pre-existing synthetic compounds, naturally occuring compounds, and designing and optimizing drugs to improve efficacy. All of these papers were published in May of 2021 so be sure to check it out to offer your neurons protection from ignorance! Sections in this episode: Using Pre-existing Synthetic Compounds (2.21) Using Naturally Occurring Compounds (12.36) Drug Design (26.35) ------------------------------------------------------------- PLEASE FILL OUR SURVEY TO HELP US IMPROVE OUR PODC...2021-06-2935 min
AMiNDR: A Month in Neurodegenerative Disease Research168 - Prevention and Intervention Strategies for Alzheimer's Disease: May 2021In this episode, Naila tackles 21 papers on diet, exercise, complementary therapies, cognitive training, and neurostimulation techniques. There's lots on the potential cellular mechanisms of exercise, several studies using Alzheimer's disease biomarkers as outcome measures, and even a paper on dog-assisted therapy! Hope you enjoy May's smattering of papers on pevention and intervention strategies for AD. Sections in this episode:Diet (2:52)Exercise (9:01)Multidomain Interventions (26.21)Cognitive training (34:29)Neuromodulatory techniques (37:30) ------------------------------------------------------------- PLEASE FILL OUR SURVEY TO HELP US IMPROVE OUR PODCAST, AND ENTER...2021-06-2646 min
AMiNDR: A Month in Neurodegenerative Disease Research167 - Vascular Contributions to Alzheimer Disease and Treatments Targeting the Vasculature: May 2021Elyn is back with more on all things vasculature! In this episode, she covers 14 papers that span many topics in the field of vascular contributions to Alzheimer disease - all the way from mechanisms linking cardiovascular and metabolic health to the Alzheimer pathology, to clinical studies associating cognitive symptoms with markers of cerebrovascular damage. Tune in to hear a perspective on AD that's outside of the amyloid cascade hypothesis! Sections in this episode:Overlap Between Cardiovascular Disease and AD (3:56)Clinical Studies on Cerebrovascular Pathology (12:20)Microvascular and Blood-Brain Barrier Changes i...2021-06-2534 min
AMiNDR: A Month in Neurodegenerative Disease Research166 - Imaging of Connectivity Changes in Alzheimer's Disease: May 2021Come join us as Judy covers all topics related to connectivity changes in Alzheimer's Disease. This episode features the latest research on both structural and functional connectivity using methods such as resting-state fMRI, DTI and EEG. Tune in to find out more! Sections in this episode: fMRI (2:00) MRI (10:51) Other (15:43) ------------------------------------------------------------- PLEASE FILL OUR SURVEY TO HELP US IMPROVE OUR PODCAST, AND ENTER A DRAW FOR A $30 GIFT CARD. Link if you prefer to copy/paste: https://amindr.hostedincanadasurveys.ca/417377?lang=enREGARDLESS...2021-06-2421 min
AMiNDR: A Month in Neurodegenerative Disease Research165 - Understanding ApoE in Alzheimer's Disease: May 2021In this episode, Courtney takes you through the papers from May 2021 on Understanding ApoE in Alzheimer's disease! We will be covering papers focused on genetic risk factors, biomarkers associated with ApoE status, risk factors for AD and finally, molecular mechanisms of ApoE! There is a wide range of topics so be sure tune in for this exciting episode! Sections in this episode:Genetic Risk Factors (2:12)Biomarkers in Alzheimer's Disease (7:15)Risk Factors of Alzheimer's Disease (12:10)Mechanisms of ApoE in Alzheimer's Disease (18:07) -------------------------------------------------------------- PLE...2021-06-2325 min
AMiNDR: A Month in Neurodegenerative Disease Research164 - Synaptic Transmission in Alzheimer's Disease: May 2021Ellen kicks off the May 2021 series with 20 papers all about synaptic transmission in Alzheimer's Disease. This includes topics like synaptic plasticity, neurotransmitters like acetylcholine, dopamine, and serotonin and how they're involved in AD, growth factors, morphological changes, and much more! Enjoy the show! Sections in this episode:Neurogenesis (5:11)Synaptic Plasticity (8:46)Neurotransmitter Signaling (18:26)Excitation/Inhibition Balance (28.07)Growth Factors (32:16)Morphological & Anatomical Changes (35:46)-------------------------------------------------------------- PLEASE FILL OUR SURVEY TO HELP US IMPROVE OUR PODCAST, AND ENTER A DRAW FOR A $30 GIFT CARD. ...2021-06-2245 min
AMiNDR: A Month in Neurodegenerative Disease Research163 - Treatments targeting Oxidative Stress & Metabolism in Alzheimer's disease: March 2021If you are interested in oxidative stress in Alzheimer’s disease, mitochondrial dysfunction, or metabolism, come hear about the ways they can be targeted for therapeutic purposes. Maybe you are tired of hearing about cholinesterase inhibitors or anti-amyloid-beta antibodies and want to explore something different. Tune in with Sarah in this last episode for our series on the papers published in March 2021. She covers 17 abstracts that harness the interconnectedness between mechanisms involved in AD pathology to develop new therapeutics and repurpose others (used in diabetes, hypertension, depression,…) Ready. Set. Play! Sections in this episode:T...2021-05-2943 min
AMiNDR: A Month in Neurodegenerative Disease Research162 - Familial Mutations, New Variants, and More Genetic Insights in Alzheimer's Disease: March 2021In this short episode, Joseph goes over 9 studies published in March 2021 that include GWAS’s, ethnicity-specific genetic studies and research on familial AD genetics. Tune in to learn more! Sections in this episode: GWAS and other population level studies (2:22) Ethnicity Specific Studies (7:44) Familial AD Genetics (11:28) -------------------------------------------------------------- To access the folder with all the bibliographies for 2021 so far, follow this link (it will be updated as we publish episodes and process bibliographies), or click the following link below:https://drive.google.com/drive/folders/1N1zx_itPkCDNY...2021-05-2816 min
AMiNDR: A Month in Neurodegenerative Disease Research161 - Amyloid-Beta Processing & Aggregation in Alzheimer's Disease: March 2021Jacques takes you on a journey through 22 papers on amyloid-beta & aggregation. Ranging from new techniques for amyloid-beta detection, APP-processing, co-pathology & Prion-like mechanisms and some miscellaneous topics pioneering the AD field. Guess you'll just have to stick around until the end! Sections in this episode: Amyloid-beta processing (2:02) Amyloid-beta detection (13:00) Amyloid-beta membrane interactions (18:35) Proteins controlling aggregation, prion protein & prion-like transmission (29:20) Amyloid-beta & Inflammation (41:17) Miscellaneous (45:35) -------------------------------------------------------------- To access the folder with all the bibliographies for 2021 so far, follow this link (it will be updated as we publish e...2021-05-2751 min
AMiNDR: A Month in Neurodegenerative Disease Research160 - Treatments targeting the Immune System, Glia, Autophagy & Proteostasis in Alzheimer's Disease: March 2021In this episode, you'll hear about the latest research on targeting neuroinflammation, glial cells, autophagy and proteoastis to treat Alzheimer's Disease. This includes some studies that want to increase neuroinflammation and some that want to decrease it! How can they both work? You'll have to listen to find out. Sections in this episode: Treatments targeting Neuroinflammation and Neurodegeneration (3:31) Proteostasis and Autophagy (24:58) --------------------------------------------------------------You can find the bibliography for this episode by clicking here. To access the folder with all the bibliographies for 2021 so far, follow this link (it wi...2021-05-2633 min
AMiNDR: A Month in Neurodegenerative Disease Research159 - Clinical Markers of Alzheimer's Disease Part 2: March 2021In Part 2 of Clinical Markers of AD, Naila will take you through 10 papers on the diagnostic and prognostic value of neuropsychiatric, sensory, motor, or a combination of symptoms. You'll learn about pareidolia, extrapyramidal symptoms, wandering behaviour and more! Sections in this episode: Multiple Symptoms (2:47) Neuropsychiatric Symptoms (6:51) Sensory Symptoms (11:05) Motor Symptoms (18:23) -------------------------------------------------------------- To access the folder with all the bibliographies for 2021 so far, follow this link (it will be updated as we publish episodes and process bibliographies), or click the following link below:https://drive.g...2021-05-2525 min
AMiNDR: A Month in Neurodegenerative Disease Research158 - Clinical Markers of Alzheimer's Disease Part 1: March 2021In part 1 of the clinical markers of AD episodes, Ellen will tell you about papers from March 2021 all about cognition. This includes papers on new cognitive tests, improving or adapting old ones to new situations, learning more about how useful these different assessments really are, AND some really cool papers at the end on new technology and machine learning tools to make AD diagnosis and detection even better! Sections in this episode: Multi-Domain Cognitive Testing (3:16) Naming & Recall (11:41) Executive Function (17:06) Emotion Recognition (19:11) Amyloid-beta & Cognitive Decline (22:06) Machin...2021-05-2439 min
AMiNDR: A Month in Neurodegenerative Disease Research157 - Changes to Gene Expression in Alzheimer's Disease: March 2021Transcriptional and translational dysregulation may cause changes in cellular biology and can lead to disease. In this episode, Marcia brings you the latest research in March 2020 that focus on changes in gene & protein expression and epigenetics in the context of Alzheimer’s disease. Some common terms you’ll hear throughout this episode are transcriptomics, methylome, biomarkers, proteomics, AD models, etc. We also touch upon the up-and-coming field of multiomics, so tune in to hear more! Sections in this episode: Gene expression and transcriptomics (2:03) Gene expression of truncated proteins (7:11) Model organisms...2021-05-2234 min
AMiNDR: A Month in Neurodegenerative Disease Research156 - Detection of Amyloid, Tau and New PET Targets in Alzheimer's Disease: March 2021In today's episode, we'll be taking a closer look at papers published in March 2021, studying amyloid and tau PET targets in Alzheimer's Disease, as well as some new PET targets. Topics covered include but are not limited to: butyryrlcholinesterase targeting, PET image processing, and animal models. Sections in this episode: Amyloid/Tau PET Targets Tau pathology (1:08) PET image processing and data analysis (6:45) Animal models (11:53) Miscellaneous (14:47) Other PET Targets Butyrylcholinesterase (17:50) Miscellaneous (20:43) --------------------------------------------------------------To access the folder with all the...2021-05-2124 min
AMiNDR: A Month in Neurodegenerative Disease Research155 - Prevention & Intervention Strategies for Alzheimer's Disease: March 2021We've got a tour de force of prevention and intervention papers for you today, covering vascular function, cognitive function, diet, exercise, neuromodulatory techniques and stem cell therapies. Naila will take you throuh 20 papers to update you on the AD literature from March 2021! --------------------------------------------------------------You can find the bibliography for this episode by clicking here. To access the folder with all the bibliographies for 2021 so far, follow this link (it will be updated as we publish episodes and process bibliographies), or click the following link below:https://drive.google.com/drive/folders/1N1...2021-05-2044 min
AMiNDR: A Month in Neurodegenerative Disease Research154 - Role of the Immune System & Glial Cells in Alzheimer's Disease: March 2021In this episode, Courtney takes you through the papers from March of 2021 on the Role of Immune systems and glial cells in Alzheimer's disease pathology! We will be discussing papers related to neuroinflammatory pathways in microglia and astrocytes, systemic inflammation and so much more! Tune in for this exciting episode! Sections in this episode: Systemic Inflammation (2.02) Neuroinflammation in Humans (6.27) Astrocytes in AD (9.41) Microglia in AD (13.24) Neuroinflammation in Animal Models (27.38) --------------------------------------------------------------You can find the bibliography for this episode by clicking...2021-05-1932 min
AMiNDR: A Month in Neurodegenerative Disease Research153 - Understanding Cognitive & Behavioural Changes in Alzheimer's Disease: March 2021Tune in as Ellen updates you on all things cognition and behaviour in Alzheimer's disease. Particularly, she'll tell you about new studies from March 2021 that shed light on the characteristics of cognitive and behavioural symptoms in AD, and the underlying neural mechanisms. This episode covers a lot of ground -- memory, executive function, the sense of smell, depression, chewing, and so much more! You're sure to learn a lot in this jam-packed episode. Sections in this episode: Characterizing Cognitive Changes in AD (2:27) Underlying Neuropathology of Cognitive Symptoms (8:23) Olfaction (15:28) Psyc...2021-05-1842 min
AMiNDR: A Month in Neurodegenerative Disease Research151 - Brain Metabolic, Hemodynamic, and Connectivity Changes in Alzheimer's Disease: March 2021In this shorter episode, Judy goes through metabolic changes, hemodynamics and functional connectivity papers on Alzheimer's disease, all published in March 2021. Aside from our favorites PET, MRI and EEG, we also look into studies that use less common techniques like SPECT imaging, retinography and MEG. Join us for just 20 minutes of neuroimaging fun! Sections in this episode: PET (1:05) MRI (5:27) EEG (10:24) Other (13:01) --------------------------------------------------------------To access the folder with all the bibliographies for 2021 so far, follow this link (it will be updated as we publish episode...2021-05-1520 min
AMiNDR: A Month in Neurodegenerative Disease Research149 - Epidemiology of Risk Factors for Alzheimer's Disease, Part 2: March 2021In part 2 of epidemiological studies from March 2021, a particularly loopy, end-of-week Naila will take you through 22 papers on comorbidities and health conditions linked to Alzheimer's disease. We've got some papers on general frailty and comorbidity burden, treatments for other diseases, sleep apnea, cardiovascular risk factors and vision impairment. Sections in this episode:Comorbidities in general (frailty, dermatitis, cancer, head injury,...) (2.00)Focus on sleep apnea (18.30)Focus on cardiovascular risk (21.36)Ophthalmic conditions (30.27) --------------------------------------------------------------You can find the bibliography for this episode by clicking here. To access the folder with...2021-05-1337 min
AMiNDR: A Month in Neurodegenerative Disease Research148 - Epidemiology of Risk Factors for Alzheimer's Disease, Part 1: March 2021In part 1 of epidemiological studies from March 2021, Naila will take you through 12 papers covering prevalence and incidence rates of AD, sociodemographic factors, the potential effects of loneliness, and more. Follow up with Part 2 if you'd like to learn about comorbidities and health risk factors linked to AD! -------------------------------------------------------------- You can find the bibliography for this episode by clicking here. To access the folder with all the bibliographies for 2021 so far, follow this link (it will be updated as we publish episodes and process bibliographies), or click the following link below:https://dri...2021-05-1229 min
AMiNDR: A Month in Neurodegenerative Disease Research147 - Treatments targeting neuroprotection, synaptic activity & neurotransmitter release in Alzheimer's Disease: March 2021Anusha will be summarizing for you papers published in March of 2021 that address neuronal and synaptic health in models of Alzheimer’s disease. That’s not all! We are also going to explore the topic of restoring neurotransmitter balance. So if for instance, you’re looking for research on acetylcholinesterase inhibition, this episode is for you! Sections in this episode: Targeting neuro/synaptic protection with peptides (2.29) Using existing drugs (9.42) Disease mechanisms (17.26) Targeting acetylcholine (21.03) Targeting GABA (26.10) Drug discovery (27.57) Drug development (33.02) -------------------------------------------------------------- To access th...2021-05-1143 min
AMiNDR: A Month in Neurodegenerative Disease Research146 - Understanding APOE in Alzheimer's Disease: March 2021Hooray! The first episode of our March 2021 series is here! In this episode, Courtney takes you through the papers from March 2021 on Understanding ApoE in Alzheimer's disease! We will be covering papers focused on ApoE in cognition, ApoE on biomarkers and pathology, and mechanisms of ApoE! There is a wide range of topics so be sure tune in for this exciting episode! Sections in this episode: Impact of ApoE on Cognition (2:06) Biomarkers in AD (8:43) Metabolism (14:37) Molecular Mechanisms of ApoE (18:52) --------------------------------------------------------------You can find the bib...2021-05-1024 min
AMiNDR: A Month in Neurodegenerative Disease Research124 - Treatments targeting Neurotransmitter Balance in Alzheimer's Disease: January 2021Anusha is your guide through 14 papers which target neurotransmitter balance. These papers were all published in January 2021 and focus mostly on targeting acetylcholinesterase activity with a sprinkling of other targets such as NMDA receptors. If you love synapses and are dying to find out how we can get them working properly again in AD, make sure to give this episode a listen! Sections in this episode: Targeting Acetylcholinesterase Activity (2:25) Other targets (18:33) --------------------------------------------------------------You can find the bibliography for today's episode here. To access the folder with t...2021-03-1424 min
AMiNDR: A Month in Neurodegenerative Disease Research123 - Advances in Cognitive & Neuropsychiatric Testing for Alzheimer's Disease Diagnosis: January 2021In this episode, Maria covers papers from January 2021 exploring cognitive and neuropsychiatric assessments that can be used to evaluate early AD or progression to AD. The studies look at tests and questionnaires related to learning and memory, functional status, and neuropsychiatric symptoms, including online adaptations of cognitive assessments when in-person visits are not always possible. Sections in this episode: Different tests for learning and memory as potential MCI or AD biomarkers (1:54) Assessments of function (17:19) Neuropsychiatric Tests (20:31) Online platforms to assess early cognitive changes (27:42) ...2021-03-1333 min
AMiNDR: A Month in Neurodegenerative Disease Research122 - The Role of Immune Systems & Glial Cells in Alzheimer's Disease: January 2021In this episode, Courtney takes you through the papers from 2021 on the role of Immune systems and glial cells in Alzheimer's disease pathology. The papers relate to neuroimaging, astrocytes, microglia, and broader inflammatory topics and pathways. Be sure to tune in for this exciting episode! Sections in this episode: Neuroimaging and Alzheimer's disease (2:01) Methods of studying inflammation (5:40) LPS-induced inflammation (7:59) Astrocytes (11:40) Microglia Neuropathology (15:27) Molecular mechanisms of Microglia (20:22) Gut inflammation and the brain (30:25) Inflammation in general (33:41) ------------------------------------------------------------------ To access...2021-03-1239 min
AMiNDR: A Month in Neurodegenerative Disease Research117 - Understanding Cognitive & Neuropsychiatric Changes in Alzheimer's Disease: January 2021Ellen covers papers published this past January on cognitive and neuropsychiatric symptoms in AD and the mechanisms behind them. You'll hear about sensory processing, cognitive and memory deficits, psychiatric symptoms and emotions, and sleep and circadian rhythms in the context of AD. Tune in to learn about the potential mechanisms behind these symptoms, and how they correspond to disease progression. Sections in this episode: Sensory Processing (Olfaction, Vision, and Pain) (3:41) Cognition & Memory (13:32) Psychiatric Symptoms & Emotions (18:37) Sleep & Circadian Rhythms (23:35) ------------------------------------------------------------------ Click here to see the li...2021-03-0631 min
AMiNDR: A Month in Neurodegenerative Disease ResearchSPECIAL: ONE YEAR WITH AMINDR!What role does social media play in academia and science communication nowadays? How can we keep our biases from interfering with fair reporting and objective coverage? Do we need to revise our inclusion criteria for the papers we cover? How relevant is the categorization of research by disease when there is so much overlap in underlying mechanisms? And how much responsibility do we hold through our podcast in shaping people’s understanding of these papers?Today you will hear from Sarah Louadi, Ellen Koch, Elyn Rowe, and Naila Kuhlmann, for a special celebratory episode for our anniversary. Tha...2020-11-151h 07
AMiNDR: A Month in Neurodegenerative Disease ResearchSPECIAL: ONE YEAR WITH AMINDR!What role does social media play in academia nowadays? How can we keep our biases from interfering with fair reporting and objective coverage? Do we need to revise our inclusion criteria for the papers we cover? How relevant is the categorization of research by disease when there is so much overlap in underlying mechanisms? And how much responsibility do we hold through our podcast in shaping people’s understanding of these papers?Today you will hear from Sarah Louadi, Ellen Koch, Elyn Rowe, and Naila Kuhlmann, for a special celebratory episode for our anniversary. That’s right, Novem...2020-11-141h 07
AMiNDR: A Month in Neurodegenerative Disease ResearchModifiable Risk Factors: Alzheimer's Disease June 2020 (Part 2)Having trouble keeping up with the literature in Alzheimer's Disease? We are here to help! You'll hear more from Naila in this episode on the papers published in June 2020 on modifiable risk factors in AD. This includes lifestyle and comorbidities. Enjoy!To receive the list of papers covered (with timestamps), please subscribe to our mailing list. You can do so by filling this form: --------> https://forms.gle/CVVbznAFM8pamdgk6 -------or by sending us an email at ---------> amindrpodcast@gmail.com-----------------------------------------------------------------------List of sections i...2020-08-0327 min
AMiNDR: A Month in Neurodegenerative Disease ResearchModifiable Risk Factors: Alzheimer's Disease June 2020 (Part 1)Having trouble keeping up with the literature in Alzheimer's Disease? We are here to help! This is the first of a two-part episode, where Naila covers the papers published in June 2020 on modifiable risk factors in AD, namely: cognitive reserve, diet, comorbidities, sleep, ... Stay tuned for the second part!To receive the list of papers covered (with timestamps), please subscribe to our mailing list. You can do so by filling this form: --------> https://forms.gle/CVVbznAFM8pamdgk6 -------or by sending us an email at ---------> amindrpodcast@gmail.com2020-08-0152 min
AMiNDR: A Month in Neurodegenerative Disease ResearchCognitive Changes & Synaptic Transmission: Alzheimer's Disease June 2020Having trouble keeping up with the literature in Alzheimer's Disease? We are here to help! In this episode, we cover the papers published in June 2020 about cognitive changes and synaptic transmission in Alzheimer's disease. You get 2 for 1! To receive the list of papers covered (with time-stamps), please subscribe to our mailing list. You can do so by filling this form: --------> https://forms.gle/CVVbznAFM8pamdgk6 -------or by sending us an email at ---------> amindrpodcast@gmail.com-----------------------------------------------------------------------List of sections in this episode: Cognitive...2020-07-2923 min
AMiNDR: A Month in Neurodegenerative Disease ResearchTreatment Development in Alzheimer's Disease-February 2020 - Part 2To receive the list of papers covered (with time-stamps), please subscribe to our mailing list. You can do so by filling this form: --------> https://forms.gle/CVVbznAFM8pamdgk6 -------or by sending us an email at ---------> amindrpodcast@gmail.com-----------------------------------------------------------------------List of sections in this episode:Targeting Acetylcholinesterase/the cholinergic system (1.56)Targeting the glutamatergic system (10.13)Targeting tau phosphorylation/tau protein (11.22)Targeting Amyloid-beta mediated toxicity (12.48)Targeting Amyloid-beta production (16.16)Antibody-mediated approaches/immunotherapies (17.43)Targeting inflammatory processes (22.00)Targeting oxidative stress (29.57)Targeting mitochondria (36.28)Targeting metabolism (39.07)Gut microbiota (40.28)Multi-targeted approaches and neuroprotective compo...2020-07-211h 03
AMiNDR: A Month in Neurodegenerative Disease ResearchTreatment Development in Alzheimer's Disease-February 2020- Part 1To receive the list of papers covered (with time-stamps), please subscribe to our mailing list. You can do so by filling this form: --------> https://forms.gle/CVVbznAFM8pamdgk6 -------or by sending us an email at ---------> amindrpodcast@gmail.com-----------------------------------------------------------------------List of sections in this episode:New approaches in drug development (1.45)Drug refinement & repurposing (30.31)Non-pharmacological approaches/behavioral interventions (48.53)In the next episode (part 2), you will hear about pre-clinical testing, which involves papers where at least one experiment was conducted on animals. -----------------------------------------------------------------------This...2020-07-171h 00
AMiNDR: A Month in Neurodegenerative Disease ResearchGenetics, Risk Factors & New diagnostic tools_AD_Papers published in February 2020To receive the list of papers covered (with time-stamps), please subscribe to our mailing list. You can do so by filling this form: --------> https://forms.gle/CVVbznAFM8pamdgk6 -------or by sending us an email at ---------> amindrpodcast@gmail.com-----------------------------------------------------------------------List of sections in this episode: 1. Genetic landscape (1.43)2. Modifiable risk factors (27.13)3. Diagnostic methods (58.24) -----------------------------------------------------------------------This episode was curated and produced by a group of volunteers. As we work on producing full-length episodes on ALL the p...2020-06-291h 37
AMiNDR: A Month in Neurodegenerative Disease ResearchPapers published on Alzheimer's disease in February 2020: Methods & ModelsAbout the bibliography: To receive the list of papers covered (with time-stamps), please subscribe to our mailing list. You can do so by filling this form: https://forms.gle/jJM9dK4SufapQkey8 or by sending us an email at amindrpodcast@gmail.com List of sections in this episode: Lab techniques (1.35)New animal models (19.32)Old animal models (27.16)New cellular models (28.27)Tissue engineering (32.42)Human methodology (34.14)Computational modeling (47.48) This episode was curated and produced by a group of volunteers. As we work on producing full-length episodes on ALL...2020-06-161h 05
AMiNDR: A Month in Neurodegenerative Disease ResearchPapers published on Alzheimer's disease in February 2020: Disease MechanismsAbout the bibliography: To receive the list of papers covered (with time-stamps), please subscribe to our mailing list. You can do so by filling this form: https://forms.gle/jJM9dK4SufapQkey8 or by sending us an email at amindrpodcast@gmail.com List of sections in this episode: (1.09) Neuroinflammation/glial cells(14.40) Protein aggregation and post-translation modification (eg: phosphorylation, misfolding), protein-protein interactions(33.31) Cell metabolism (mitochondrial dysfunction, lipids, hormones)(39.00) Neuronal plasticity : cell proliferation, differentiation, maturation, survival + cell death + survival/protection(42.11) Cerebrovascular changes(45.49) Synaptic Transmission(54.33) Autophagy This e...2020-06-0859 min
AMiNDR: A Month in Neurodegenerative Disease ResearchWelcome to AMiNDR!Do you have feedback? Suggestions? Please take a few minutes to fill our survey, so we can better refine our platform: https://forms.gle/RzZcaEMHuqj4awhh8Interested in joining the team? Get in touch with us! We are specifically looking for people who can help develop content (write summaries and sort papers), but also welcome individuals who want to contribute in other ways.You can subscribe to receiving the bibliography for each episode, by sending us an email at: amindrpodcast@gmail.comAre you on twitter? Give us a shout: @AMiNDR_podcast...2020-06-0834 min