Shows
AMiNDR: A Month in Neurodegenerative Disease Research239 - Prevention & Intervention Strategies for Alzheimer's Disease: October 2021We've got a short and sweet episode for you today, with 7 papers from October 2021 on the intervention and prevention of AD. Tune in to hear Naila ramble on about pet therapy, update you on diet and exercise research in animal models, and provide a stimulating overview of neuromodulatory techniques. Sections in this episode: Complimentary Therapies (2:55) Lifestyle Interventions (9:30) Stimulation Techniques (13:28) -------------------------------------------------------------- You can find the numbered bibliography for this episode by clicking here, or the link below:https://drive.google.com/file/d/1C7WBstTEh5Fhfr_bsOdjX...2021-12-2020 min
AMiNDR: A Month in Neurodegenerative Disease Research236 - Detecting Amyloid, Tau & New Markers in the Brain: October 2021To kick off our series on papers published in October 2021, we'll look at 7 papers that rely on Positron Emission Tomography (or PET) imaging to detect amyloid and tau pathology in the brain, within the context of Alzheimer's disease! If you're interested in learning about tau and amyloid based detection, alternative PET tracers in AD research, or combining PET with different imaging modalities, make sure to tune into this episode. Sections in this episode: Amyloid Detection (2:35) Tau Detection (7:40) Amyloid + Tau (10:41) Miscellaneous (12:34) -------------------------------------------------------------- To access the folder with al...2021-12-1315 min
AMiNDR: A Month in Neurodegenerative Disease Research230 - Risk Factors for Alzheimer's Disease Part 2: September 2021Back for part 2, Naila takes you through 15 papers pertaining to health conditions associated with AD and dementia. You'll hear about infections, cardiovascular and metabolic risk factors, and a few miscellaneous diseases. Sections in this episode: Epidemiology / Multiple Factors (1:00) Immune Conditions (8:00) Metabolic and Cardiovascular (15:00) Neurological Comorbidities (24:50) -------------------------------------------------------------- You can find the numbered bibliography for this episode by clicking here, or the link below:https://drive.google.com/file/d/1Pgl18mXwvDG2xZK9fijICMtfEhI7BXUG/view?usp=sharingTo access the folder with all the...2021-11-3031 min
AMiNDR: A Month in Neurodegenerative Disease Research228 - New Variants & Genetic Insights in Alzheimer's Disease: September 2021Join Glory to learn about the newest genetic variants and mechanisms that have been linked to Alzheimer's disease. In this episode, we'll cover protective and pathogenic AD variants in genes, potential genetic biomarkers for AD, and differential gene expression that can be observed in individuals with AD. With 19 papers from September 2021, you'll hear about some genes that will be worth following up on in the near future to advance our understanding of the disease! Sections in this episode: Genetic variants (3:11) Genetic biomarkers (13:58) Differential gene expression and mRNA (18:05) miRNA regulations (22:55) N...2021-11-2537 min
AMiNDR: A Month in Neurodegenerative Disease Research225 - Detecting Amyloid, Tau and New Markers in the Brain in Alzheimer's Disease: September 2021Let's take a closer look at 18 papers published in September 2021 that rely on positron emission tomography (or PET) to detect amyloid and tau pathology in the brain, within the context of Alzheimer's disease! If you're interested in learning about tau and amyloid based detection, alternative PET tracers in AD research, or combining PET with different imaging modalities, make sure to tune into this episode. Sections in this episode: Amyloid-based detection (2.35) Tau-based detection (9.35) Amyloid & Tau (21.30) Other targets (24.25) -------------------------------------------------------------- You can find the numbered bibliography for this episode...2021-11-1829 min
AMiNDR: A Month in Neurodegenerative Disease Research191 - Detection of Amyloid, Tau and new PET targets in Alzheimer's Disease: June 2021Here, we'll be taking a closer look at 14 papers published in June 2021 that rely on Positron emission tomography imaging (or PET) to detect amyloid and tau pathology in the brain, within the context of Alzheimer's disease! If you're interested in learning about tau and amyloid based detection, alternative PET tracers in AD research, or combining PET with different imaging modalities, make sure to tune it. Sections in this episode: Amyloid-beta based detection (1:30)Tau based detection (9:45)Amyloid-beta and tau (15:04)Case studies (16:48)Other PET targets (19:01)...2021-08-1322 min
AMiNDR: A Month in Neurodegenerative Disease Research185 - Metabolic Changes, Hemodynamics and EEG in Alzheimer's Disease: June 2021In this shorter episode, Judy goes over papers published in June 2021 that focus on diagnostic tools of Alzheimer's disease. Topics include metabolic changes, hemodynamics and EEG biomarkers. Listen in to find out more! Sections in this episode: Metabolic changes in AD (1:20) Hemodynamics (9:30) EEG (13:30) -------------------------------------------------------------- You can find the numbered bibliography for this episode by clicking here, or the link below:https://drive.google.com/file/d/1lzkStThvq02V_tpeuqBDfmZuLlhg6RwQ/view?usp=sharingTo access the folder with all the bibliog...2021-08-0618 min
AMiNDR: A Month in Neurodegenerative Disease Research172 - Detection of Amyloid, Tau, and other PET Targets in Alzheimer's Disease: May 2021In this episode, we’ll take a closer look at 13 papers published in May 2021, that rely on Positron emission tomography imaging (or PET) to detect amyloid and tau pathology in the brain, within the context of Alzheimer’s disease! Make sure to take a listen if you’re interested in learning more about tau and amyloid based detection, alternative PET tracers in AD research, or combining PET with different imaging modalities. Sections in this episode: Tau Based Detection (1:48) A-beta Based Detection (10:45) Tau and A-beta (18:10) Other PET Targets (19:33) ...2021-07-0222 min
AMiNDR: A Month in Neurodegenerative Disease Research170 - Hemodynamics, Metabolic Changes & EEG in Alzheimer's Disease: May 2021From working memory tasks to mouse models, and even to lexical semantics, Judy goes over a wide range of papers that study AD diagnosis using a variety of neuroimaging techniques. Check out this episode if you're interested in hearing about changes in cerebral blood flow, metabolism and EEG signals in the context of AD. You're sure to learn something new! Sections in this episode: Hemodynamics (1:05) Metabolic Changes (9:45) EEG (16:30) ------------------------------------------------------------- PLEASE FILL OUR SURVEY TO HELP US IMPROVE OUR PODCAST, AND ENTER A DRAW FOR A $30 GIFT CARD. Link...2021-06-3024 min
AMiNDR: A Month in Neurodegenerative Disease Research166 - Imaging of Connectivity Changes in Alzheimer's Disease: May 2021Come join us as Judy covers all topics related to connectivity changes in Alzheimer's Disease. This episode features the latest research on both structural and functional connectivity using methods such as resting-state fMRI, DTI and EEG. Tune in to find out more! Sections in this episode: fMRI (2:00) MRI (10:51) Other (15:43) ------------------------------------------------------------- PLEASE FILL OUR SURVEY TO HELP US IMPROVE OUR PODCAST, AND ENTER A DRAW FOR A $30 GIFT CARD. Link if you prefer to copy/paste: https://amindr.hostedincanadasurveys.ca/417377?lang=enREGARDLESS...2021-06-2421 min
AMiNDR: A Month in Neurodegenerative Disease Research161 - Amyloid-Beta Processing & Aggregation in Alzheimer's Disease: March 2021Jacques takes you on a journey through 22 papers on amyloid-beta & aggregation. Ranging from new techniques for amyloid-beta detection, APP-processing, co-pathology & Prion-like mechanisms and some miscellaneous topics pioneering the AD field. Guess you'll just have to stick around until the end! Sections in this episode: Amyloid-beta processing (2:02) Amyloid-beta detection (13:00) Amyloid-beta membrane interactions (18:35) Proteins controlling aggregation, prion protein & prion-like transmission (29:20) Amyloid-beta & Inflammation (41:17) Miscellaneous (45:35) -------------------------------------------------------------- To access the folder with all the bibliographies for 2021 so far, follow this link (it will be updated as we publish e...2021-05-2751 min
AMiNDR: A Month in Neurodegenerative Disease Research156 - Detection of Amyloid, Tau and New PET Targets in Alzheimer's Disease: March 2021In today's episode, we'll be taking a closer look at papers published in March 2021, studying amyloid and tau PET targets in Alzheimer's Disease, as well as some new PET targets. Topics covered include but are not limited to: butyryrlcholinesterase targeting, PET image processing, and animal models. Sections in this episode: Amyloid/Tau PET Targets Tau pathology (1:08) PET image processing and data analysis (6:45) Animal models (11:53) Miscellaneous (14:47) Other PET Targets Butyrylcholinesterase (17:50) Miscellaneous (20:43) --------------------------------------------------------------To access the folder with all the...2021-05-2124 min
AMiNDR: A Month in Neurodegenerative Disease Research151 - Brain Metabolic, Hemodynamic, and Connectivity Changes in Alzheimer's Disease: March 2021In this shorter episode, Judy goes through metabolic changes, hemodynamics and functional connectivity papers on Alzheimer's disease, all published in March 2021. Aside from our favorites PET, MRI and EEG, we also look into studies that use less common techniques like SPECT imaging, retinography and MEG. Join us for just 20 minutes of neuroimaging fun! Sections in this episode: PET (1:05) MRI (5:27) EEG (10:24) Other (13:01) --------------------------------------------------------------To access the folder with all the bibliographies for 2021 so far, follow this link (it will be updated as we publish episode...2021-05-1520 min
AMiNDR: A Month in Neurodegenerative Disease Research139 - Brain Metabolic, Hemodynamic, and Connectivity Changes in Alzheimer's Disease: February 2021Judy covers a wide range of neuroimaging modalities in the context of metabolics, hemodynamics and functional connectivity in AD. Tune in if you're a fan of fMRI, PET and EEG, or if you're just looking to learn something new! Sections in this episode: fMRI (1:06) PET (7:28) EEG (16:29) fNIRS (20:16) Other (23:12) -------------------------------------------------------------- To access the folder with all the bibliographies for 2021 so far, follow this link (it will be updated as we publish episodes and process bibliographies), or click the following link below:https...2021-04-1333 min
AMiNDR: A Month in Neurodegenerative Disease Research137 - Amyloid-beta Toxicity in Alzheimer's Disease: February 2021In this short episode packed full of insight, Jacques navigates the realms of amyloid-beta toxicity in AD. Learn about different techniques and models used to investigate amyloid-beta toxicity, how mouse models can provide insight into toxic amyloid-beta species and the relationship of certain amyloid-beta species with clinical presentations. Sections in this episode: Techniques for Investigating Amyloid-beta Toxicity (2:17) Amyloid-beta Toxicity within Different Cell Types and Species (5:53) Mouse models of Alzheimer’s Disease(12:52) Amyloid-beta Toxicity and Humans (17:01) -------------------------------------------------------------- You can find the bibliography for this episode by...2021-04-1226 min
AMiNDR: A Month in Neurodegenerative Disease Research135 - Detection of Amyloid, Tau and new PET targets in Alzheimer's Disease: February 2021Follow along with Alex in this episode, as we take a closer look at papers studying amyloid and tau PET targets in Alzheimer's Disease, as well as some new PET targets at the end of the episode. We'll cover topics including deep learning, cerebral amyloid angiopathy, and using the retina as a way of indirectly accessing the brain! Sections in this episode: Amyloid and tau-based detection (1:30) Subsection: Animal models (10:00) Subsection: Deep learning (12:25) Subsection: Cerebral amyloid angiopathy (15:07) Other pet targets (17:24) --------------------------------------------------------------You c...2021-04-0921 min
AMiNDR: A Month in Neurodegenerative Disease Research126 - Brain Metabolic, Hemodynamic and Connectivity Changes in Alzheimer's Disease: January 2021In this episode we’ll cover all things metabolism, hemodynamics and connectivity in the brain, in AD. We’ll cover 26 papers published in January 2021, that dive deeper into these research topics, so tune in! Sections in this episode: Metabolism (1:42) Hemodynamic (4:28) Connectivity changes (11:46) Miscellaneous (24:56) --------------------------------------------------------------To access the folder with the bibliographies for the month of January, follow this link (it will be updated as we publish episodes and process bibliographies), or click the following link below:https://drive.google.com/drive/folders/1tK...2021-03-1737 min
AMiNDR: A Month in Neurodegenerative Disease Research115 - Detection of amyloid, tau and new PET markers in Alzheimer's Disease: January 2021This longer episode features amyloid and tau detection in the brain, as well as new PET targets of AD! Judy discusses papers from January 2021 that include topics such as AD mouse models, deep learning methods and several different PET tracers. Tune in to find out more! Sections in this episode: PET (1:54) Non-PET (32:51) New PET Targets (35:22) ------------------------------------------------------------------ To access the folder with the bibliographies for the month of January, follow this link (it will be updated as we publish episodes and process bibliographies), or click the follo...2021-03-0439 min
AMiNDR: A Month in Neurodegenerative Disease Research112 - Changes to RNA, Transcription & Translation in Alzheimer's Disease: January 2021In today’s episode, Marcia brings you the latest research from Jan 2021 on changes to RNA, Transcription and Translation in the context of Alzheimer’s disease. We also talk about some really in-fashion techniques like multi-omics, deconvolution, mendelian randomization and co-localization. Tune in to learn about these techniques and more! Sections in this episode: Multiomics (2 papers) 1:10 Mendelian randomization and colocalization (3) 3:45 Gene pathway and network analysis (2) 7:21 Differential gene expression/deconvolution (2) 9:41 Methylation (2) 12:35 Post translational modifications (2) 15:19 microRNAs (3) 17:38 Miscellaneous (2) 22:53 ------------------------------------------------------------------ Click here to see...2021-03-0126 min
AMiNDR: A Month in Neurodegenerative Disease Research103 - Mechanisms underlying Risk Factors for Alzheimer's Disease: September 2020This episode covers recent papers that explore the underlying mechanisms of both protective and risk factors of Alzheimer’s disease. You’ll hear a little about how education, exercise and diet might reduce the risk of cognitive decline later in life, and a lot about the physiological and biochemical factors underlying high fat diets, diabetes, cardiovascular disease and exposure to environmental pollutants - with the occasional miscellaneous topic in between! Sections in this episode: 1:35 Protective factors 7:50 Risk factors (diet, diabetes, cardiovascular) 26:16 Vitamin Deficiencies and AD 29:27 Environmental Exposures and AD 2021-01-2941 min
AMiNDR: A Month in Neurodegenerative Disease Research98 - Cerebrovascular changes in Alzheimer's Disease Part 2: September 2020In this episode, Elyn caps off the papers on Cerebrovascular Changes in AD from September 2020. There’s mounting evidence for a significant overlap between vascular disease and brain health, and Elyn dives into the newest papers exploring this relationship. Tune in to hear about how cerebral small vessel disease might be the mediator between arteriosclerosis and cognitive impairment, how APOE is related to microbleeds, and how ACE1 inhibitors might be relevant in AD! Sections in this episode: 1:50 - Relationship between Cerebral Small Vessel Disease & AD 11:40 - Cerebral Small Vessel Disease & AD Progre...2021-01-2220 min
AMiNDR: A Month in Neurodegenerative Disease Research94 - Brain Imaging of Structural Changes & Connectivity in Alzheimer's Disease, Part 1: September 2020Bhumika updates you on the latest papers on brain imaging of structural changes and connectivity in AD! This includes MRI and PET imaging to characterize or diagnosis this disease, as well as new machine learning technology, and more! Enjoy, and look out for part 2 soon! ------------------------------------------------------------------ To receive the list of papers covered, please fill this form: --------> https://forms.gle/CVVbznAFM8pamdgk6 ------- or by tweeting at us: @AMiNDR_podcast ------------------------------------------------------------------ We would appreciate your feedback so we can better cater to your needs. You can f...2021-01-1524 min
AMiNDR: A Month in Neurodegenerative Disease Research92 - Fluid Biomarkers for Alzheimer's Disease Part 2: September 2020Elyn is back with more on fluid biomarkers for Alzheimer’s Disease from September 2020 papers. Here, she covers new candidate biomarkers including panels of lipids, soluble TREM2, and methylation sites on known risk genes. She also dives into insight into APOE4 mechanisms revealed by biomarkers, the stark overlap between vascular dementia and Alzheimer’s disease, and much more. This is a long one, but definitely worth a listen! Sections in this episode: Lipids - 6 papers - 3:22 Hormones/lipoproteins - 3 papers - 13:05 Metabolites - 4 papers - 17:31 Inflammation...2021-01-1346 min
AMiNDR: A Month in Neurodegenerative Disease Research85 - Fluid Biomarkers for Alzheimer's Disease Part 1: September 2020Interested in the mission to accurately diagnose Alzheimer’s disease with a blood test? This episode is perfect for you. In this two-part episode on Fluid Biomarkers in AD from September 2020 papers, Elyn explains the ATN framework for AD diagnosis, and covers papers focused on fluid biomarkers relating to amyloid, tau, and neurodegeneration. She also touches on a few new methods for biomarkers researchers. Tune in to hear about how storage conditions can affect measurements, how assay platforms compare, and new methods for isolating exosomes! Sections in this episode: Combination of the Classics: 3:44 Amyloid beta...2020-12-2330 min
AMiNDR: A Month in Neurodegenerative Disease Research83 - Treatments targeting amyloid-beta aggregation and more in Alzheimer's Disease: September 2020In this episode, Marcia covers papers published in September 2020 that focus on the latest in novel drug development in AD. We especially talk about papers targeting amyloid-beta aggregation, BACE-1 inhibitors, gamma-secretase, immunotherapy for AD and more! Tune in to learn more. 5:46 - BACE-1 9:09 - Gamma secretase11:12 - More papers on amyloid-beta aggregation------------------------------------------------------------------ To receive the list of papers covered, please fill this form: --------> https://forms.gle/CVVbznAFM8pamdgk6 ------- or by tweeting at us: @AMiNDR_podcast ------------------------------------------------------------------ We would appreciate your feedback so we can...2020-12-2127 min
AMiNDR: A Month in Neurodegenerative Disease Research81 - Cerebrovascular changes in Alzheimer's Disease Part 1: September 2020Elyn is back to cover the latest findings relating to the cerebrovasculature in Alzheimer disease! In this two part episode covering papers from September 2020, you’ll hear about how aging and systemic inflammation can influence the blood-brain barrier, how circulating “good cholesterol” can protect the blood vessels and may be dysfunctional in AD, and a whole lot about cerebral small vessel disease. ------------------------------------------------------------------ To receive the list of papers covered, please fill this form: --------> https://forms.gle/CVVbznAFM8pamdgk6 ------- or by tweeting at us: @AMiNDR_podcast ------------------------------------------------------------------ We would...2020-12-2024 min
AMiNDR: A Month in Neurodegenerative Disease Research78 - Multi-Targeted Treatment Approaches for Alzheimer's Disease Part 2 + Gene Therapy: September 2020This episode is the second half of a two part series covering papers published in September 2020 on treatment approaches with multiple targets for Alzheimer’s disease. For part 1 of this series, check out episode 74! In this part, we’ll take a look at papers targeting many different AD processes, including oxidative stress, cholinesterase activity, and amyloid beta formation. The final paper in this episode will cover a new study using gene therapy to target AD. ------------------------------------------------------------------ Sections in this episode: 2:04 Treatments with multiple targets 18:05 (1 paper) Gene therapy ------------------------------------------------------------------ To receive the list...2020-12-1420 min
AMiNDR: A Month in Neurodegenerative Disease Research74 - Multi-Targeted Treatment Approaches for Alzheimer's Disease Part 1: September 2020In this episode, Alex will be covering papers published in September 2020 within the category of novel drug development, that focus on multi-targeted approaches to Alzheimer’s disease treatment. We’ll take a look at papers targeting many different AD processes, including oxidative stress, cholinesterase activity, and amyloid beta formation. Part 2 will be coming out shortly! ------------------------------------------------------------------ To receive the list of papers covered, please fill this form: --------> https://forms.gle/CVVbznAFM8pamdgk6 ------- or by tweeting at us: @AMiNDR_podcast ------------------------------------------------------------------ We would appreciate your feedback so we can be...2020-12-0624 min
AMiNDR: A Month in Neurodegenerative Disease Research54 - CSF Biomarkers: Alzheimer's Disease August 2020In this episode, Alex covers the latest research involving CSF biomarkers as a critical diagnostic tool in Alzheimer’s Disease identification and treatment. You’ll hear about some of the more typical clinical CSF biomarkers seen in AD, as well as the signature CSF AD biomarker profile, and you’ll also learn about how some of these CSF biomarkers relate to the different stages of AD progression and severity. ------------------------------------------------------------------ To receive the list of papers covered, please fill this form: --------> https://forms.gle/CVVbznAFM8pamdgk6 ------- or by tweeting at us: @AMiND...2020-11-1620 min