Shows
AMiNDR: A Month in Neurodegenerative Disease Research331 - Treatments Targeting Neuroprotection in Alzheimer's Disease: February 2023This short and sweet episode kicks off the February 2023 series, highlighting studies all the way from worms to humans. Anusha will take you through 9 papers that converge on targeting neuroprotection in Alzheimer's disease. If you're interested in learning about implicated pathways or potential therapeutics, this episode is sure to whet your appetite. Sections in this episode: Targeting Specific Neuroprotective Pathways (3:39) Targeting Neuroprotection Broadly (13.21) -------------------------------------------------------------- You can find the bibliography for this episode here, or by clicking the link below:https://drive.google.com/file/d/1n7wQss1hiT-F...2023-05-0223 min
AMiNDR: A Month in Neurodegenerative Disease Research323 - The Immune System & Glia in Alzheimer's Disease Part 1: November 2022Welcome our new host, Anelya, who covers 12 papers on the role of immune system and glia in Alzheimer’s disease. The first half of this episode will focus on potential targets for the treatment of Alzheimer’s disease, followed by the disease-associated inflammatory mechanisms. Part 2 will be released as a bibliography. We hope you find this episode interesting! Sections in this episode: Potential Therapeutic Agents (2:28) Disease-Associated Neuroinflammatory Mechanisms (14:08) -------------------------------------------------------------- To find the numbered bibliography with all the papers covered in this episode, click here, or use the link below:http...2023-03-0927 min
AMiNDR: A Month in Neurodegenerative Disease Research322 - Functional Connectivity & Imaging in Alzheimer's Disease: November 2022Ellen brings you summaries of 8 abstracts from November 2022, all about functional connectivity and imaging in the context of Alzheimer's disease. There are a variety of brain regions covered in today's episode, including cortical regions, subcortical structures, and the hippocampus. Spanning studies in both humans and animals, this episode is sure to have something of interest to you and your research! Sections in this episode: Cortical regions (3:39) Subcortical forebrain regions (8:57) Hippocampus (14:30) -------------------------------------------------------------- To find the numbered bibliography with all the papers covered in this episode, click here, or use th...2023-03-0721 min
AMiNDR: A Month in Neurodegenerative Disease Research319 - Cognitive & Behavioural Changes in Alzheimer's Disease Part 1: November 2022Judy is so excited to take you through part 1 of the behavioural and cognitive changes in AD episode (part 2 will be released as a bibliography). This shorter episode features standard motor symptoms like impaired exercise and grip strength, as well as some less studied behavioural changes such as adverse driving in AD. You don’t want to miss this one! Sections in this episode: Behavioural Changes (3:30) Learning History (13:45) Depressive Symptoms (15:32) -------------------------------------------------------------- To find the numbered bibliography with all the papers covered in this episode, click here, or use the...2023-02-2120 min
AMiNDR: A Month in Neurodegenerative Disease Research318 - Synaptic Transmission in Alzheimer's Disease: November 2022Ellen kicks off the November 2022 series with 11 papers about synaptic transmission and neurotransmitters in Alzheimer's disease. Hear about glutamate, acetylcholine, synaptic proteins, and more in this jam-packed episode! Sections in this episode: Glutamate and Acetylcholine (4:01) GABA neurons (10:52) Neuron Excitability (12:15) Synaptic Proteins (15:10) Neuro-Immuno-Endocrine System (21:45) -------------------------------------------------------------- To find the numbered bibliography with all the papers covered in this episode, click here, or use the link below:https://drive.google.com/file/d/1dELth-9F_TVyUTuxPmuIVYKM1MgCuIEf/view?usp=share_linkTo access t...2023-02-1626 min
AMiNDR: A Month in Neurodegenerative Disease Research313 - Synaptic Transmission in Alzheimer's Disease: October 2022Kick off the new year with Ellen, who tells you all about synaptic transmission in Alzheimer's disease in this episode. You'll hear about 5 papers published in October of 2022 on synaptic transmission, ranging from research on whole brain networks all the way down to individual proteins. -------------------------------------------------------------- To access the numbered bibliography for this episode, click here, or use the link below:https://drive.google.com/file/d/1sIxUDc8NrG6HAXL9ikKCCGx6KgX--ULp/view?usp=share_linkTo access the folder with ALL our bibliographies, follow this link (it will be updated as...2023-01-1213 min
AMiNDR: A Month in Neurodegenerative Disease Research308 - Synaptic Transmission in Alzheimer's Disease: August 2022To kick off our series on August papers, we will talk all about different ways that synaptic transmission may be affected in Alzheimer's disease, with 6 research papers that use either cell models, animal models, or human patients. Stay tuned! Sections in this episode: Cortical signaling in rodent models (3:15) New AD models (8:32) Biomarkers of neural dysfunction in humans (9:24) -------------------------------------------------------------- To find the numbered bibliography with all the papers covered in this episode, click here, or use the link below:https://drive.google.com/file/d/1iLzCzMAIoIYq7fW_zJ2...2022-12-0816 min
AMiNDR: A Month in Neurodegenerative Disease Research307 - Cognitive & Behavioural Changes in Alzheimer's Disease Part 2: July 2022In Part 2 of Cognitive and Behavioural Changes, Naila covers 8 papers on neuropsychiatric, social and cognitive symptoms linked to Alzheimer's disease, and their implications for diagnosis and disease management. You'll learn about the links between AD and depression, the importance of social networks, and machine learning methods for identifying important lifestyle information from clinical notes. Enjoy! Neuropsychiatric Changes (2:11)Cognitive Changes (10:25)Statistics and Machine Learning (17:05)-------------------------------------------------------------- To find the numbered bibliography with all the papers covered in this episode, click here, or use the link below:https://dr...2022-11-0423 min
AMiNDR: A Month in Neurodegenerative Disease Research305 - Treatments Targeting Neuroprotection in Alzheimer's Disease: July 2022This is an episode all about targeting synaptic and neuronal heath in Alzheimer's disease. Anusha will cover in silico, in vitro, and in vivo studies of candidate compounds that target neuroprotection and neurogenesis. Be sure to check out this paper to stay up to day on the latest preclinical therapeutics being tested. Sections in this episode: In silico and treatment development (3:24) Targeting Neurogenesis (7:07) Targeting Neuroprotection (12:00) -------------------------------------------------------------- To find the numbered bibliography with all the papers covered in this episode, click here, or use the link below:http...2022-10-2726 min
AMiNDR: A Month in Neurodegenerative Disease Research304 - Understanding APOE: July 2022In this episode exploring the effect of allelic variation of APOE, we review abstracts from large human GWAS studies all the way down to new mouse models expressing the human ApoE proteins. There are some particularly interesting abstracts on protection from cognitive decline despite having a risk allele for Alzheimer's disease. These are great studies to open the door for future research in this field! Sections in this episode: Human Research (2:58) Mice Research (15:53) -------------------------------------------------------------- To find the numbered bibliography with all the papers covered in this episode, click here, or us...2022-10-2025 min
AMiNDR: A Month in Neurodegenerative Disease Research301 - Synaptic Transmission in Alzheimer's Disease: July 2022We are kicking off our July 2022 series of AMiNDR with this episode and are so glad you are tuning in. If you’re interested in changes to neuronal function in AD, we’ll be covering the entire spectrum in this episode. Starting big with network changes, we scale all the way down to molecular changes that may underlie AD pathology, so if that’s what you’re interested in, stay tuned! Sections in this episode: Special Mention of Blots in a Field? (3:39) Network Dysfunction (4:53) Synaptic Dysfunction (12:09) Molecular Changes (22:33) ...2022-10-1230 min
AMiNDR: A Month in Neurodegenerative Disease Research284 - Cognitive Assessment in Alzheimer's Disease Part 2: March 2022Welcome back for the second of a 2-part episode on the clinical assessment of Alzheimer’s disease, based on abstracts published in March 2022! You will hear about the evaluation of traditional and digital tests for their potential to help us detect AD and distinguish it from MCI. Also on the menu, a few papers on markers of cognitive decline that may help us refine our diagnosis, or even for prognostic purposes. Yes, you read this correctly, all this goodness packed in 1 episode! Sections in this episode: Evaluating Existing Tests (7:31) Identifying Markers for Cognitive Decli...2022-06-0636 min
AMiNDR: A Month in Neurodegenerative Disease Research282 - Treatments Targeting Neuroprotection in Alzheimer's Disease: March 2022Another 12 papers published in March of 2022 awaits you. This episode is all about treatments that target neuroprotection to treat AD. The papers model it by inducing cytotoxicity in the brain, either with molecules like amyloid beta or genetic mutations. Anusha is excited to guide you through promising treatment options, are you excited too? Sections in this episode: Stem Cell-Based Therapy (3.01) Testing compounds in A-Beta AD Models (4.52) Testing compounds in APP/PS1 AD Model (14.49) Test compounds in other AD Models (17.15) -------------------------------------------------------------- To find the numbered bibliography with al...2022-05-2622 min
AMiNDR: A Month in Neurodegenerative Disease Research281 - Synaptic Transmission in Alzheimer's Disease: March 2022Ease in to our March 2022 series with 8 papers published on the subject of synaptic transmission in Alzheimer's Disease. Anusha will highlight changes to connectivity and ones caused by APP and Tau proteins so check out this episode to bridge the communication gap in your brain too! Sections in this episode: Synaptic Connectivity Changes (1.44) APP/Tau contribution to Synaptic Dysfunction (7.47) -------------------------------------------------------------- To find the numbered bibliography with all the papers covered in this episode, click here, or use the link below:https://drive.google.com/file/d/1BY9b9lZ7...2022-05-2418 min
AMiNDR: A Month in Neurodegenerative Disease Research272 - Risk Factors for Alzheimer's Disease Part 1: January 2022In Part 1 of this 2-part episode on epidemiological studies published in January 2022, Naila will take you through 12 papers on risk and protective factors linked to Alzheimer's disease, ranging from stressful life events, to exposure to greenspace in one's neighborhood, to sleep troubles and testosterone. We cover a lot of ground in this episode, and if you want to cover even more, look out for Part 2 coming soon! Sections in this episode: Sociodemographic and Lifestyle Factors (2:11) Miscellaneous Health Factors (15:01) -------------------------------------------------------------- To find the numbered bibliography with all the papers covered in th...2022-03-3128 min
AMiNDR: A Month in Neurodegenerative Disease Research271 - Vascular Contributions to Alzheimer's Disease: January 2022With her first episode covering papers from 2022, Elyn is back with a lot of new and interesting findings implicating blood-brain barrier dysfunction in Alzheimer disease. Tune in to hear about this and much more in this longer episode covering 15 papers published in January 2022! Sections in this episode: Clinical Insights - Vascular Risk Factors (3:46) Blood-Brain Barrier Dysfunction (9:41) Amyloid Deposition and Clearance (30:31) Treatment Avenues (35:22) -------------------------------------------------------------- To find the numbered bibliography with all the papers covered in this episode, click here, or use the link below:https...2022-03-2940 min
AMiNDR: A Month in Neurodegenerative Disease Research270 - Treatments Targeting Neuroprotection in Alzheimer's Disease: January 2022Pssst. Did you hear that 14 papers were published in January of 2022 on treatments targeting synaptic and neuronal protection in Alzheimer's disease? Anusha has you covered with papers targeting amyloid-beta-induced cytotoxocity, demyelination, and cognitive dysfunction in animal models. Sections in this episode: Treatments using stem cells (2.18) Protecting against A-beta induced toxicity (4.59) Protecting against glutamate-induced cytotoxicity (9.20) Treatments tested in transgenic AD-like mice (12.38) Treatments tested in AD rat models (17.13) -------------------------------------------------------------- To find the numbered bibliography with all the papers covered in this episode, click here, or use the...2022-03-2626 min
AMiNDR: A Month in Neurodegenerative Disease Research269 - Structural Changes in the Brain in Alzheimer's Disease: January 2022What information do grey and white matter tell us about mild cognitive impairment vs. Alzheimer's disease? Enjoy this episode in which Christy goes over study findings from 12 papers published in January 2022 on the topic of structural brain changes related to AD. Sections in this episode: Gray and white matter changes (2.25) Correlations of structural changes with biomarkers (9.28) Methods for early detection (15.27) Software packages for brain volumetry (19.03) Radiomic (22.56) -------------------------------------------------------------- To find the numbered bibliography with all the papers covered in this episode, click here, or use the...2022-03-2428 min
AMiNDR: A Month in Neurodegenerative Disease Research267 - Synaptic Transmission in Alzheimer's Disease: January 2022We start off our January 2022 series of AMiNDR with this episode highlighting 9 papers on changes to synaptic transmission in Alzheimer's Disease. In this episode, Anusha will cover topics including changes to GABAergic and glutamatergic transmission and calcium flux in AD-affected neurons. We also have papers looking at age-dependent changes in synaptic function in AD. End neuro-transmission ;) Sections in this episode: Changes to GABAergic transmission (2.41) Changes to calcium flux (6.42) Changes to glutamateric transmission (8.38) Age-dependent changes in AD (13.11) -------------------------------------------------------------- To find the numbered bibliography with all the papers...2022-03-1421 min
AMiNDR: A Month in Neurodegenerative Disease Research265 - Treatments Targeting Neuroprotection in Alzheimer's Disease: December 2021In this short and sweet episode, Anusha will take you through 7 papers published in December of 2021 on the subject of treatments targeting neuronal and synaptic protection in AD. Exercise your cognitive reserve by tuning into this episode! Sections in this episode: Testing Naturally-Derived Compounds (3.35) Testing Pre-Existing Drugs (10.54) -------------------------------------------------------------- To find the numbered bibliography with all the papers covered in this episode, click here, or use the link below:https://drive.google.com/file/d/1Hiyw6KCbidwmpO12pL1unqbHOJYSLbDd/view?usp=sharingTo access the folder with...2022-03-0219 min
AMiNDR: A Month in Neurodegenerative Disease Research264 - Tau Protein Pathology in Alzheimer's Disease: December 2021Tickled by tau? Preoccupied with post-translational modifications? Join Kate as she covers the latest papers published in December 2021 on tau protein pathology and targeting tau as a therapeutic strategy in Alzheimer's disease. Sections in this episode: Tau Aggregation & Post-Translational Modifications (3:19) Generalized Tau Pathology & Tau Seeding (7:29) Treatments Targeting Tau in AD (13:50) -------------------------------------------------------------- To find the numbered bibliography with all the papers covered in this episode, click here, or use the link below:https://drive.google.com/file/d/1fjqrnVxElJ6O3DpCytRflRFP0Td_Vg51/view?usp=sharingT...2022-02-2821 min
AMiNDR: A Month in Neurodegenerative Disease Research263 - Vascular Contributions to Alzheimer's Disease: December 2021Tired of the amyloid cascade hypothesis? Think there's more to AD than the plaques and tangles? You've come to the right place! Elyn is back for her final episode covering papers from 2021 on Vascular Contributions to Alzheimer Disease. Tune in to hear about the latest findings relating to cerebrovascular changes in AD, and why they matter. Sections in this episode: Insights from Clinical Studies (4:10) Insights from Animal Models (14:47) -------------------------------------------------------------- To find the numbered bibliography with all the papers covered in this episode, click here, or use the link below:...2022-02-2424 min
AMiNDR: A Month in Neurodegenerative Disease Research262 - Prevention and Intervention Strategies for Alzheimer's Disease: December 2021In today's episode, Naila will take you through 11 studies from December 2021 on different non-pharmacological methods for treating Alzheimer's disease. You'll hear the latest research on the importance of sleep, how cognitive training might reduce Alzheimer's pathology, and numerous stimulation techniques for improving cognitive function in people with AD. Enjoy! Sections in this episode: Cognition and Sleep (1.34) Exercise (6.28) Neuromodulatory Techniques (12.16)-------------------------------------------------------------- To find the numbered bibliography with all the papers covered in this episode, click here, or use the link below:https://drive.google.com/file/d/1EK...2022-02-2227 min
AMiNDR: A Month in Neurodegenerative Disease Research261 - Clinical Assessment in Alzheimer's Disease Part 2: December 2021This episode of AMiNDR is part 2 of our Clinical Assessment series. Today, you'll hear about new cognitive tests and advancements in existing tools for clinical testing. With every new study on Alzheimer’s disease, we are one step closer to understanding this disease better, diagnosing people faster, and helping people more effectively. Get ready to hear about some of the latest ways that scientists and clinicians are getting us closer to these goals! Sections in this episode: New or Updated Assessment Tools (4:56) Evaluating Existing Tools (12:50) Cognition in Specific Populations (17:18) ...2022-02-1923 min
AMiNDR: A Month in Neurodegenerative Disease Research259 - Changes to Synaptic Transmission in Alzheimer's Disease: December 2021Could changes to synaptic transmission underlie Alzheimer's disease pathology? Anusha has 8 papers to help you answer that question. These papers assess changes in humans, human models, and animal models and were all published in December of 2021. Sections in this episode: Changes in Neuronal Activity in Humans and Human Models (2.50) Changes in Neurogenesis in APP/PS1 Transgenic AD Mice (10.08) Changes in Neuronal Activity in APP/PS1 Transgenic AD Mice (13.42) -------------------------------------------------------------- To find the numbered bibliography with all the papers covered in this episode, click here, or use the link b...2022-02-1720 min
AMiNDR: A Month in Neurodegenerative Disease Research258 - Cognitive & Behavioural Changes in Alzheimer's Disease: December 2021To kick off this series, Ellen tells you about 17 studies published in December 2021 on how different forms of cognition, sensory processing, and psychiatric health can be affected in Alzheimer's disease, as well as papers exploring new treatment options! If you are an Alzheimer's researcher, or are just interested in hearing about the latest progress in this field, you don't want to miss this episode! Sections in this episode: Sensory Function & Processing (3:38) Emotional Processing (9:24) Language (11:15) Future Thinking (13:21) Preclinical Testing in AD Models (14:38) Comparing Different Diseases (21:09) Clinic...2022-02-1535 min
AMiNDR: A Month in Neurodegenerative Disease Research256 - Autophagy and Proteostasis in Alzheimer's Disease: November 2021Tired of only hearing about tau or a-beta when it comes to AD research? Take a peek behind the scenes with Kate to explore the latest on the proteostasis and autophagy pathways that work to safeguard our cells in 13 papers from November 2021. Sections in this episode: Autophagy & Proteostasis Pathology (4:17) Targeting Proteostasis/Autophagy Machinery (22:21) -------------------------------------------------------------- To find the numbered bibliography with all the papers covered in this episode, click here, or use the link below:https://drive.google.com/file/d/1qO6ISzG2igk1NtzKi19x08Dw4wO7FNeQ...2022-02-0828 min
AMiNDR: A Month in Neurodegenerative Disease Research255 - Treatments Targeting Neuroprotection and Neurotransmission in Alzheimer's Disease: November 202117 papers have "Targeting neurotransmission and synaptic dysfunction in AD" written all over it. Figuratively speaking of course. Anusha covers topics like targeting neurotoxicity and calcium flux, or acetylcholine transmission and balance, or even targeting monoamine oxidases to improve AD-like pathology. Better yet, this episode lets you keep up to date as all the papers were published in November of 2021. Sections in this episode: Targeting synaptic dysfunction (2.34) Targeting M1 acetylcholine receptors (14.03) Targeting cholinesterases by modifying existing drugs (17.32) Targeting cholinesterases with novel drugs (22.49) Targeting monoamine oxidases (27.31) -------------------------------------------------------------- To...2022-02-0432 min
AMiNDR: A Month in Neurodegenerative Disease Research252 - Clinical Assessment of Alzheimer's Disease: November 2021Welcome all researchers, students, and clinicians who are interested in learning about clinical testing for Alzheimer’s disease! This episode is dedicated to papers published back in November 2021 on new and old assessment methods to help in the diagnosis of Alzheimer’s. This includes testing cognitive processes and performance on activities of daily living, detecting Alzheimer’s, and distinguishing it from other dementias. You will hear about some new cognitive and non-cognitive parameters to consider as well, so tune in for your monthly fill of news in the field! Sections in this episode: Existing cognitive tests (7...2022-01-2937 min
AMiNDR: A Month in Neurodegenerative Disease Research250 - Changes to Synaptic Transmission in Alzheimer's Disease: November 2021You have just entered the magical world of Alzheimer’s literature. You are about to experience 8 papers that do their best to better understand the changes in synaptic transmission in Alzheimer’s disease. Where did we find such curious abstracts you ask? It just so happens that these were all papers published in November of 2021. Ready to go? Close your eyes and let Anusha be your guide through this journey of curiosity. Sections in this episode: Synaptic Changes in AD Mouse Models (2.27) AD-related changes to Lipid Regulation (11.25) -------------------------------------------------------------- To find the...2022-01-2517 min
AMiNDR: A Month in Neurodegenerative Disease Research249 - Cognitive & Behavioural Changes in Alzheimer's Disease: November 2021To kick off the November 2021 series, Ellen brings you 11 papers published this past November on the topic of Alzheimer's disease and dementia. Tune in to hear about research on chronic stress, sleep quality, and an active compound from the cannabis plant that could be used to treat AD symptoms! That's just a taste of what you'll hear about in this episode that covers a diverse array of research all about cognition and behavioural symptoms in AD. Sections in this episode: Mild Behavioural Impairment (3:31) Perception (5:35) Stress & Psychiatric Disturbances (7:28) Sleep (15:47) Pote...2022-01-2127 min
AMiNDR: A Month in Neurodegenerative Disease Research247 - Risk Factors for Alzheimer's Disease Part 2: October 2021Naila is back for part 2, to take you through epidemiological studies on lifestyle factors and comorbidities related to Alzheimer's disease. In today's episode, you'll learn about dietary factors, the association between hair loss and AD, and even a little about Covid-19 (sorry!). Lots to learn in just 13 papers! Sections in this episode: Lifestyle factors (1:39) Nutrition (7:08) Physical and Psychiatric Comorbities (13:30) -------------------------------------------------------------- You can find the numbered bibliography for this episode by clicking here, or the link below: https://drive.google.com/file/d/1PTf3HweI53JJNntYHZlSRjfcJFuOcLJW/view?us...2022-01-1427 min
AMiNDR: A Month in Neurodegenerative Disease Research245 - Synaptic Transmission in Alzheimer's Disease: October 2021Thinking about thinking? Changes to synaptic transmission contribute to Alzheimer's disease pathology. Hear all about 10 papers published in October of 2021 exploring synaptic dysfunction in AD from Anusha who hosts this episode. Sections in this episode: Synaptic dysfunction in rodent AD models (2.58) Synaptic dysfunction in other AD models & human studies (16.41) -------------------------------------------------------------- You can find the numbered bibliography for this episode by clicking here, or the link below: https://drive.google.com/file/d/1LYhcoVeGPq5QEWzCqqDCvJsOgMdo3jKt/view?usp=sharingTo access the folder with all the biblio...2022-01-1023 min
AMiNDR: A Month in Neurodegenerative Disease Research244 - Vascular Contributions to Alzheimer's Disease: October 2021Elyn is back with your monthly update on vascular contributions to Alzheimer disease! This month she covers 8 papers that primarily focus on the blood-brain barrier, and white matter hyperintensities that reflect cerebrovascular abnormalities. Tune in for some exciting new findings in the field and more data emphasizing the importance of vascular health in dementia. Sections in this episode: White Matter Hyperintensities (4:13) Blood-Brain Barrier (13:57) Cerebral Amyloid Angiopathy (20:02) -------------------------------------------------------------- You can find the numbered bibliography for this episode by clicking here, or the link below: https://drive.google...2022-01-0723 min
AMiNDR: A Month in Neurodegenerative Disease Research242 - New Variants & Genetic Insights Part 2: October 2021Welcome to our first episode of 2022! Marcia will bring you 13 genetics papers from October 2021. We will talk about all kinds of topics - right from AD-associated loci to polygenetic risk stratification, all of which can contribute to planning effective treatment strategies. Tune in! Sections in this episode: Transcriptomics/Gene Expression Changes (2:33) Genetic Variants (6:16) Genetic Risk (13:14) MicroRNA (20:10) Other Topics (22:52) -------------------------------------------------------------- You can find the numbered bibliography for this episode by clicking here, or the link below: https://drive.google.com/file/d/1ZmtkgGyhe...2022-01-0427 min
AMiNDR: A Month in Neurodegenerative Disease Research240 - Treatments Targeting Neuroprotection and Neurotransmission: October 2021Hello there! Just in time for the holiday season we've got quite the deal lined up for you. Two episodes for the length of one! Anusha will be guiding you through the literature of October 2021 that focuses on targeting neuronal function and neurotransmission as an Alzheimer's disease treatment. If you want to find out the progress we've been making as a field towards finding better treatments, this is the episode for you! Sections in this episode: Targeting neuronal and synaptic protection (2.33) Targeting neurotransmission (13.27) -------------------------------------------------------------- You can find the numbered bibli...2021-12-2224 min
AMiNDR: A Month in Neurodegenerative Disease Research239 - Prevention & Intervention Strategies for Alzheimer's Disease: October 2021We've got a short and sweet episode for you today, with 7 papers from October 2021 on the intervention and prevention of AD. Tune in to hear Naila ramble on about pet therapy, update you on diet and exercise research in animal models, and provide a stimulating overview of neuromodulatory techniques. Sections in this episode: Complimentary Therapies (2:55) Lifestyle Interventions (9:30) Stimulation Techniques (13:28) -------------------------------------------------------------- You can find the numbered bibliography for this episode by clicking here, or the link below:https://drive.google.com/file/d/1C7WBstTEh5Fhfr_bsOdjX...2021-12-2020 min
AMiNDR: A Month in Neurodegenerative Disease Research231 - Understanding Cognitive & Behavioural Changes in Alzheimer's Disease: September 2021Ellen tells you about research on topics such as cognitive reserve, reinforcement learning, psychiatric conditions, sleep issues, speech, and more in this jam-packed episode on cognitive and behavioural changes in Alzheimer's Disease. Sections in this episode: General Cognition (3:32) Reinforcement Learning (14:09) Speech and Language (16:33) Visuospatial and Motor Control (25:06) Psychiatric Changes (28:15) Sleep and Circadian Rhythms (35:16) -------------------------------------------------------------- You can find the numbered bibliography for this episode by clicking here, or the link below:https://drive.google.com/file/d/1PjokO3cFgLOjtRyi9yjQlckHRNKMtiEM/view?usp=s...2021-12-0243 min
AMiNDR: A Month in Neurodegenerative Disease Research230 - Risk Factors for Alzheimer's Disease Part 2: September 2021Back for part 2, Naila takes you through 15 papers pertaining to health conditions associated with AD and dementia. You'll hear about infections, cardiovascular and metabolic risk factors, and a few miscellaneous diseases. Sections in this episode: Epidemiology / Multiple Factors (1:00) Immune Conditions (8:00) Metabolic and Cardiovascular (15:00) Neurological Comorbidities (24:50) -------------------------------------------------------------- You can find the numbered bibliography for this episode by clicking here, or the link below:https://drive.google.com/file/d/1Pgl18mXwvDG2xZK9fijICMtfEhI7BXUG/view?usp=sharingTo access the folder with all the...2021-11-3031 min
AMiNDR: A Month in Neurodegenerative Disease Research229 - Risk Factors for Alzheimer's Disease Part 1: September 2021In today's episode, Naila takes you through 10 papers on risk factors associated with Mild Cognitive Impairment, Alzheimer's and dementia. You'll hear a little on lifestyle factors, air and noise pollutants, and hormones. Stay tuned for Part 2! Sections in this episode: Lifestyle & Environmental Factors (2:09) Hormones (15:13) -------------------------------------------------------------- You can find the numbered bibliography for this episode by clicking here, or the link below:https://drive.google.com/file/d/1BUfTeMbAC0HzYcXRieJSQdsoNKS9r2J7/view?usp=sharingTo access the folder with all the bibliographies for 2021 so far, follo...2021-11-2721 min
AMiNDR: A Month in Neurodegenerative Disease Research228 - New Variants & Genetic Insights in Alzheimer's Disease: September 2021Join Glory to learn about the newest genetic variants and mechanisms that have been linked to Alzheimer's disease. In this episode, we'll cover protective and pathogenic AD variants in genes, potential genetic biomarkers for AD, and differential gene expression that can be observed in individuals with AD. With 19 papers from September 2021, you'll hear about some genes that will be worth following up on in the near future to advance our understanding of the disease! Sections in this episode: Genetic variants (3:11) Genetic biomarkers (13:58) Differential gene expression and mRNA (18:05) miRNA regulations (22:55) N...2021-11-2537 min
AMiNDR: A Month in Neurodegenerative Disease Research224 - Tau Protein Pathology in Alzheimer's Disease: September 2021Tired of untangling the tricky world of tau literature all on your own? Interested in the mechanisms of tau pathology, therapeutic advancements targeting tau, or both? Join Kate for another exciting episode covering 20 new papers published in September 2021. We’ll explore tau aggregation, regulation, and treatment development through a wide variety of model systems, from molecular dynamics all the way to human subjects - so, tune in to learn more! Sections in this episode: New tau pathological findings (3.17) Tau and Neuroinflammation (7.46) Tau Aggregation (10.24) Tau Pathology from Prion-like Seeding Behaviour (13.24) Tre...2021-11-1636 min
AMiNDR: A Month in Neurodegenerative Disease Research223 - Treatments Targeting Neurotransmission in Alzheimer's Disease: September 202118 papers published in September of 2021 await you. What do they all have in common? They explore treatments for Alzheimer's disease that all target neurotransmission. If you're interested in restoring acetylcholine balance or other treatments that also improve cognitive function in Alzheimer's disease, tune in to hear Anusha take you through the literature. Sections in this episode: Discovery and synthesis of novel cholinesterase inhibitors (3.17) Tacrine-based cholinesterase inhibitors (11.26) Modifying existing treatments (16.16) Multi-target treatments (23.00) -------------------------------------------------------------- You can find the numbered bibliography for this episode by clicking here, or the lin...2021-11-1227 min
AMiNDR: A Month in Neurodegenerative Disease Research222 - Changes to Synaptic Transmission in Alzheimer's Disease: September 2021Are you interested in neuronal hyperexcitability, impairments in synaptic plasticity, and interactions between amyloid plaques and synaptic proteins in Alzheimer's disease pathology? You've come to the right podcast! In this episode, Glory will guide you through 11 publications from September 2021 on the latest research about the mechanisms of synaptic transmission and plasticity that contribute to the Alzheimer's disease. Hit that play button to hear all of the exciting new insights on the AD synapse. Sections in this episode: Neurotransmitters systems involved in AD (2:56) Neuronal structure (11:42) Neuron Excitability (14:33) Amyloid beta and APP a...2021-11-1126 min
AMiNDR: A Month in Neurodegenerative Disease Research221 - Treatments Targeting Synaptic & Neuronal Protection in Alzheimer's Disease: September 2021The first episode of our September 2021 series gets us acclimated with papers that target neuronal and synaptic function in preclinical studies of Azheimer's disease. Join Anusha and she walks you through papers that explore topics like rescuing amyloid beta-induced toxicity, restoring neuronal morphology, and using animal models of Alzheimer's disease to target neuronal function. Sections in this episode: Targeting A-Beta-Induced Toxicity (2.21) Restoring Neuronal Morphology and Promoting Neurogenesis (7.26) Restoring Neuronal Function in AD Animal Models (15.40) -------------------------------------------------------------- You can find the numbered bibliography for this episode by clicking here, or the...2021-11-0823 min
AMiNDR: A Month in Neurodegenerative Disease Research220 - Clinical Markers of Alzheimer's Disease Part 2: August 2021This is part 2 of our episode on clinical markers for Alzheimer’s disease, where we cover papers published in August 2021. How does a translation of your favourite cognitive test perform in a Chinese, Slovenian or Persian population? What measures are we currently ignoring but should be include in our battery of tests to detect Alzheimer’s disease or mild cognitive impairment? There is new stuff on this regularly, so come get your monthly fill of research news, maybe you’ll find a gem that will influence your practice, in research or in the clinic. Sections in this episode...2021-11-0432 min
AMiNDR: A Month in Neurodegenerative Disease Research219 - Clinical Markers of Alzheimer's Disease Part 1: August 2021Do you want to brush up on your knowledge of MoCA, ADAS-Cog, the MMSE and other cognitive tests? Join Sarah to hear about the 7 papers published in August 2021 where we’re evaluating existing tests for their specificity and sensitivity in detecting Alzheimer's disease and mild cognitive impairment. -------------------------------------------------------------- You can find the numbered bibliography for this episode by clicking here, or the link below:https://drive.google.com/file/d/1w5W2UPrmR7vRgFtjsWj4KBMXh3qhFHoN/view?usp=sharingTo access the folder with all the bibliographies for 2021 so fa...2021-11-0228 min
AMiNDR: A Month in Neurodegenerative Disease Research218 - Cognitive and Behavioural Changes in Alzheimer's Disease: August 2021In today's episode of AMiNDR, we’ll be talking about the latest work on cognitive and behavioural changes in Alzheimer's Disease, including papers on executive functioning, depression, social impairments, motor coordination, and more. Join Ellen as she guides you through 18 papers on the mechanisms behind cognition and other neuropsychological symptoms in AD! Sections in this episode: Cognitive Profiles (4:07) Executive Functions (13:06) Exercise & Cognition (18:12) Psychiatric & Social Symptoms (21:54) Motor Coordination & Balance (34:09) Sleep & Circadian Rhythms (35:52) -------------------------------------------------------------- You can find the numbered bibliography for this epi...2021-10-3041 min
AMiNDR: A Month in Neurodegenerative Disease Research217 - Autophagy & Proteostasis in Alzheimer's Disease: August 2021Are you familiar with protein aggregation in Alzheimer's disease, but want to learn more about the mechanisms cells use to fight back against these stubborn species? Join Kate in exploring the landscape of cellular processes governing proteostasis and autophagy as they relate to AD. In this short-but-sweet episode, we'll cover a total of 7 papers focused on AD pathology involving autophagy and/or proteostasis dysfunction, as well as treatments targeting these processes. If you're new to these terms, or in need of a cell bio refresher, don't sweat it! - we'll be kicking off the episode with a quick primer...2021-10-2819 min
AMiNDR: A Month in Neurodegenerative Disease Research215 - Treatments Targeting Mitochondria & Metabolism: August 2021Join Marcia as she explores the what’s, how’s, and why’s of all things oxidative stress, mitochondrial dysfunction and metabolism in AD. With this month’s - August 2021- papers, you’ll hear about the latest related cell and animal model studies, AD-adjunct diabetes, and even about potential therapeutics! So sit back and enjoy! Sections in this episode: Metabolism (2.40) Oxidative Stress (11.02) Mitochondrial Dysfunction (22.25) -------------------------------------------------------------- You can find the numbered bibliography for this episode by clicking here, or the link below:https://drive.goog...2021-10-2333 min
AMiNDR: A Month in Neurodegenerative Disease Research214 - Risk Factors for Alzheimer's Disease: August 2021Make yourself comfortable, because we cover a lot of ground in today's episode. Naila will guide you through 24 papers from August 2021, all pertaining to epidemiological studies on the risk and protective factors related to AD. You'll hear about some basic epidemiology, environmental and socioeconomic risk factors, lifestyle factors, and health conditions related to AD. Sections in this episode: Epidemiology & Social Factors (1.52) Diet (16.53) Sleep (24.19) Comorbidities (28.00) -------------------------------------------------------------- You can find the numbered bibliography for this episode by clicking here, or the link below:https://drive.google...2021-10-2147 min
AMiNDR: A Month in Neurodegenerative Disease Research212 - Synaptic Transmission in Alzheimer's Disease: August 2021Want to know more about about how the brain's different neurotransmitter systems aren't functioning properly in Alzheimer's disease and how hippocampal synaptic plasticity impairment contributes to Alzheimer's pathology? Join Glory for the latest updates on research about the mechanisms of synaptic transmission and plasticity that contribute to the Alzheimer's disease pathology. With this month's new papers, August 2021 gives us 12 publications that try to answer all of your questions on the synaptic aspects of AD! You're sure to get your own synapses firing by listening to this episode! Sections in this episode: Neurotransmitters and neuropeptides (3:01) E...2021-10-1624 min
AMiNDR: A Month in Neurodegenerative Disease Research210 - Tau Protein Pathology in Alzheimer's Disease: August 2021Today, Kate will be focusing on everything tau-related in 12 papers published in August 2021, including aspects of tau pathology and exploring potential therapeutics targeting tau in Alzheimer’s disease! Sections in this episode:Tau Aggregation & Post-Translational Modifications (PTMs) (3.16)Tau Pathology & Seeding (13.30)Targeting Tau for Treatment (20.10)-------------------------------------------------------------- You can find the numbered bibliography for this episode by clicking here, or the link below:https://drive.google.com/file/d/1IIilzUhWAF_WuBM4trkcW12daiB52sT2/view?usp=sharingTo access the folder with all the...2021-10-1229 min
AMiNDR: A Month in Neurodegenerative Disease Research209 - Treatments targeting Neurotransmission in Alzheimer's Disease: August 2021This is an episode that explores the creation and testing of drugs that aim to restore neurotransmitter balance in Alzheimer's disease. It covers 14 papers that were all published in August of 2021, and Anusha will guide you through papers on targets including cholinesterases, serotonin, and glutamate receptors. Hit that play button if you'd like to hear more. Sections in this episode: Targeting acetylcholine with novel compounds (2.29) Other targets with novel compounds (13.23) Testing for or improving upon existing ACE inhibitors (17.28) -------------------------------------------------------------- You can find the numbered bibliog...2021-10-0924 min
AMiNDR: A Month in Neurodegenerative Disease Research208 - Prevention & Intervention Strategies in Alzheimer's Disease: August 2021In this short and sweet episode, Naila covers 7 new papers on prevention and intervention of Alzheimer's disease. You'll hear about upcoming clinical trials of behavioural and cognitive interventions, a little bit about the mechanisms underlying the therapeutic effects of exercise, and about non-invasive stimulation techniques for treating AD. Sections in this episode: Cognitive / Physical Training (1:57) Neuromodulatory Techniques (9:27) -------------------------------------------------------------- You can find the numbered bibliography for this episode by clicking here, or the link below:https://drive.google.com/file/d/1W9coBE5hJ7I8Np...2021-10-0717 min
AMiNDR: A Month in Neurodegenerative Disease Research206 - Prevention & Intervention Strategies in Alzheimer's Disease: July 2021Today's episode covers 18 papers on prevention and intervention strategies for Alzheimer's disease and dementia. Naila will take you through clinical trials and animal studies on cognitive training programs, complementary therapies, diet, exercise, and neuromodulatory techniques. There's a lot of unique papers in this one, so we hope you enjoy! Sections in this episode: Cognitive Training (2:52) Complementary Therapies (6:08) Diet (15:30) ; Exercise (19:56) Neuromodulatory Techniques (28:51) -------------------------------------------------------------- You can find the numbered bibliography for this episode by clicking here, or the link below:https://drive.google.c...2021-09-2336 min
AMiNDR: A Month in Neurodegenerative Disease Research205 - Treatments targeting neurotransmission in Alzheimer's Disease: July 2021Journey through the entire spectrum of drug development as Anusha guides you through 19 papers that were published in July of 2021. We span research that begins with drug discovery all the way to the end goal: Phase II clinical trials. If you're interested in targeting levels of acetylcholine and monoamines, you're really going to like this episode! Sections in this episode: Synthesis and Discovery of Cholinesterase Inhibitors (2.47) Drug Interactions with Multiple targets (9.29) Pre-clinical Trials (18.23) Clinical Trials (25.39) -------------------------------------------------------------- You can find the numbered bibliography for this...2021-09-2230 min
AMiNDR: A Month in Neurodegenerative Disease Research204 - Clinical Markers of Alzheimer's Disease Part 2: July 2021In this episode, Ellen tells you about 9 papers that have developed new ways to screen for dementia. Some of these are old, tried-and-true cognitive screening tools that are given a new twist, others are brand new technology that bring cognitive testing to the modern age. You’re sure to find something you enjoy in this episode if you do neurodegenerative disease research, or even if you don’t! Sections in this episode: Technology-based tools (3:44) Adapting tests to other languages (8:34) Other new tools for testing cognition (12:22) -------------------------------------------------------------- You ca...2021-09-2121 min
AMiNDR: A Month in Neurodegenerative Disease Research203 - Clinical Markers of Alzheimer's Disease Part 1: July 2021In the first part of this 2-parter episode, Ellen covers studies that compare and contrast different cognitive tests, or analysis techniques, for diagnosing AD at early stages, or predicting the conversion of pre-dementia stages to Alzheimer’s Disease. There are also some studies that compare cognitive abilities between different types of dementia. You'll hear about memory, spatial awareness, social cognition, and more! Sections in this episode: Cognitive decline & memory (3:32) Semantic fluency (16:42) Social cognition (18:21) Spatial awareness (21:47) -------------------------------------------------------------- You can find the numbered bibliography for this e...2021-09-1725 min
AMiNDR: A Month in Neurodegenerative Disease Research202 - Tau protein pathology in Alzheimer's Disease: July 2021Kate brings you the latest research on tau pathology in Alzheimer's Disease. This includes post-translational modifications, tau aggregation and seeding, and targeting tau in treatment development. Enjoy! Sections in this episode: Tau Pathology (4:35) Post-translational modifications (4:56) Tau aggregation and seeding behaviour (16:30) Targeting Tau for Treatment Development (21:09) -------------------------------------------------------------- You can find the numbered bibliography for this episode by clicking here, or the link below:https://drive.google.com/file/d/1xBMvUdqdBPnGQDnv9qBk9icbKBNEbdXZ/view?usp=sharingTo access the folde...2021-09-1626 min
AMiNDR: A Month in Neurodegenerative Disease Research201 - Vascular Contributions to Alzheimer's Disease: July 2021Interested in how the 700km of blood vessels in the brain are linked to Alzheimer disease? Turns out there are a lot of common threads! In this episode, Elyn covers a series of clinical and preclinical papers exploring vascular risk factors, genetic risk factors like APOE, and signs of vascular damage that are linked to Alzheimer disease. Tune in for an exciting perspective on Alzheimer disease, outside of the classic amyloid cascade hypothesis! Sections in this episode: Clinical Studies: Cardiovascular Risk Factors and Cerebrovascular Pathology (4:22) Lymphatic/Glymphatic Drainage (13:48) Preclinical Modell...2021-09-1522 min
AMiNDR: A Month in Neurodegenerative Disease Research199 - Treatments targeting neuroprotection in Alzheimer's Disease: July 2021Animal and cell models of Alzheimer's Disease are featured in this episode that covers potential therapeutics that target neuroprotection. We have 5 papers that focus broadly on the subject and 10 more that delve into mechanisms of action of these compounds so join Anusha as she highlights July of 2021's publications on the topic! Sections in this episode: Treatments targeting neuroprotection (1.03) Mechanism of treatments targeting neuroprotection (11.14) -------------------------------------------------------------- You can find the numbered bibliography for this episode by clicking here, or the link below:https://drive.g...2021-09-1026 min
AMiNDR: A Month in Neurodegenerative Disease Research198 - Understanding Cognitive & Behavioural Changes in Alzheimer's Disease: July 2021Visual reaction time, japanese orange scent, language, psychosis, and insomnia are just some of the topics you’ll hear about today in this episode. Have we piqued your interest? Today Ellen tells you about the latest papers on the mechanisms of, and treatments for, cognitive and behavioural changes in Alzheimer's Disease. Enjoy the show! Sections in this episode: Sensory processing & function (3:31) Speech (9:16) Learning & memory (11:17) Psychiatric changes (13:50) Sleep (21:20) -------------------------------------------------------------- You can find the numbered bibliography for this episode by clicking here, or the link below:...2021-09-1031 min
AMiNDR: A Month in Neurodegenerative Disease Research197 - Synaptic transmission in Alzheimer's Disease: July 2021Glory's back for another episode with all the latest updates on research about how disruptions in certain mechanisms of synaptic transmission and plasticity contribute to Alzheimer's disease. We'll be featuring 14 papers published in July 2021 that cover all things synaptic in AD, including ion channel function and LTP! Join us for an episode that's sure to stimulate your own synapses! Sections in this episode: Neurotransmitters (3:00) Neuronal excitability/activity (11:29) Structural (17:15) Synaptic Plasticity (23:15) Memory (29:52) -------------------------------------------------------------- You can find the numbered bibliography for this episode...2021-09-0934 min
AMiNDR: A Month in Neurodegenerative Disease Research196 - Changes to Gene Expression in Alzheimer's Disease: July 2021“Omics”, “differential expression” and “biomarker discovery” – Are these phrases you commonly use in your research? Or have you come across them and wondered what they meant in the context of AD? If you're nodding your head at either of those, this episode is just for you. Join Marcia as she brings you the latest research published in July 2021 on ‘RNA, Transcription and translation in AD’! Sections in this episode: Gene expression and transcriptomics (02:26) Proteomics (17:38) -------------------------------------------------------------- You can find the numbered bibliography for this episode by clicking here, or the link below...2021-09-0725 min
AMiNDR: A Month in Neurodegenerative Disease Research194 - Treatments targeting Neurotransmitter Imbalances: June 2021In this episode, Anusha will guide you through 20 papers that tackle acetylcholine and glutamate imbalances in Alzheimer's Disease. These papers were published in June of 2021 and address topics like inhibiting cholinesterases and NMDA receptors. We hope this information transmits to your neurons! Sections in this episode: Novel Anti-Cholinesterase Drugs (2.39) Existing Anti-Cholinesterase Drugs (16.28) Targeting Glutamate (26.17) -------------------------------------------------------------- To access the folder with all the bibliographies for 2021 so far, follow this link (it will be updated as we publish episodes and process bibliographies), or click the following link below:http...2021-08-1930 min
AMiNDR: A Month in Neurodegenerative Disease Research193 - Clinical Markers of Alzheimer's Disease: June 2021In this episode, Maria will be going over 17 papers published in June 2021 on Clinical Indicators of Alzheimer's diseaes and mild cognitive impairment. Topics covered will include the use of technology to assess cognition, semantic memory, cognitive tests, behavioural tests, oculomotor tests, and language adaptations. If you're interested in new ways of detecting AD, make sure you tune in! Sections in this episode:Technology for AD and MCI (2:08) Semantic Memory(8:11) Test for Aspects of Cognition (11:38) Oculomotor Markers of Cognition (20:50) Language Adaptations (23:03)-------------------------------------------------------------- Click...2021-08-1829 min
AMiNDR: A Month in Neurodegenerative Disease Research190 - Brain Connectivity Changes in Alzheimer's Disease: June 2021Interested in brain connectivity changes specific to Alzheimer's disease? Come join us as Judy presents 13 papers featuring fMRI, machine learning and other brain mapping techniques that explore functional connectivity in AD. You're sure to learn something new! Sections in this episode: fMRI (01:32) Machine Learning (12:10) Other (14:36) -------------------------------------------------------------- You can find the numbered bibliography for this episode by clicking here, or the link below:https://drive.google.com/file/d/1qQcxhvhiOUvDSfqcLh4FbI43oFEEelrm/view?usp=sharingTo access the folder with all the bib...2021-08-1320 min
AMiNDR: A Month in Neurodegenerative Disease Research188 - APP processing & Amyloid-beta aggregation in Alzheimer's Disease: June 2021Only 14 papers published on APP processing and Amyloid-beta aggregation in the month of June, what’s going on? Well, it is still our pleasure to give you brief summaries on the matter, so if you research Alzheimer’s disease, you do want to tune in for your monthly update on secretase activity, seeding of misfolding, metal ion content of aggregates, and amyloid-beta toxicity. Sections in this episode: APP Processing & Secretases (3.15) Characterizing Aggregate Content (7.00) Amyloid-β Aggregation (10.09) Downstream effects of Amyloid-β (25.16) -------------------------------------------------------------- To access the folder with all the bibli...2021-08-1130 min
AMiNDR: A Month in Neurodegenerative Disease Research187 - Prevention & Intervention Strategies for Alzheimer's Disease: June 2021In this short and sweet episode, Naila covers 12 papers from June 2021 regarding non-pharmacological strategies to prevent or intervene in dementia progression. You'll hear about a few exercise programs, some creative ways to improve quality of life for people with dementia and caregivers, and a range of neuromodulatory (stimulation) techniques. Sections in this episode: Exercise (1:37) Multidomain / Other (7:05) Neuromodulatory Techniques (15:20) -------------------------------------------------------------- You can find the numbered bibliography for this episode by clicking here, or the link below:https://drive.google.com/file/d/1y6rZuX5vL...2021-08-1027 min
AMiNDR: A Month in Neurodegenerative Disease Research186 - Treatments targeting neuronal protection in Alzheimer's Disease: June 2021Join our host Anusha as she takes you through papers published in June of 2021 that target neuroprotection as a potential treatment avenue for Alzheimer's disease. Half these papers use amyloid-beta induced models of Alzheimer's disease so be sure to check it out if neuroprotection is up your alley. Sections in this episode: Treatments targeting neuroprotection in amyloid-beta induced AD models (2.03) Neuroprotection in other AD models (12.51) -------------------------------------------------------------- You can find the numbered bibliography for this episode by clicking here, or the link below:https://drive.google.com/file/d...2021-08-0724 min
AMiNDR: A Month in Neurodegenerative Disease Research183 - Changes to Gene Expression in Alzheimer's Disease: June 2021We know how critical gene expression and its regulation is to cellular homeostasis. In light of that, it is imperative that we discuss the possibility that Alzheimer’s disease could be caused by disturbances in DNA methylation in certain genes and the potential role of methylation in being a biomarker in AD. In today's episode, Marcia brings you the latest research on this topic, summarizing 9 papers from June 2021. Sections in this episode: Transcription and differential gene expression (02:12) Methylation (09:56) Multiomics (13:29) -------------------------------------------------------------- You can find the numbered bibliography for this epi...2021-08-0418 min
AMiNDR: A Month in Neurodegenerative Disease Research182 - Cognitive & Behavioural Changes in Alzheimer's Disease: June 2021Ellen kicks off this series by telling you about the latest research from June 2021 on topics like cognition, memory, reading, gait, speech, depression, sleep, and even more. Learn how these symptoms may manifest in Alzheimer's disease patients, and the underlying mechanisms that contribute to them. If you're interested in behaviour and cognition in humans or in animals, this episode is for you! Sections in this episode: Cognition & Attention (3:32) Memory (9:59) Speech & Communication (16:31) Gait (23:05) Psychiatric Symptoms (26:58) Sleep & Circadian Rhythms (30:32) -------------------------------------------------------------- You can find the numbe...2021-08-0339 min
AMiNDR: A Month in Neurodegenerative Disease Research181 - Clinical Markers of Alzheimer's Disease Part 2: May 2021From standard clinical testing to motor assessments such as gait performance and handwriting ability, Judy will cover 10 papers on various types of markers in Alzheimer's Disease. Tune in for our final May 2021 episode and learn something new about the different techniques used in AD diagnosis! Sections in this episode: Clinical Testing (1:58) Motor Assessments (7:39) Semantic Dementia (11:28) Sleep (14:03) -------------------------------------------------------------- You can find the numbered bibliography for this episode by clicking here, or the link below:https://drive.google.com/file/d/1pKecrNPbkMwJyc_z7Yeo3P0...2021-07-1518 min
AMiNDR: A Month in Neurodegenerative Disease Research180 - Clinical Markers of Alzheimer's Disease Part 1: May 2021In this episode, Maria goes over 22 papers from May 2021 on various cognitive tests for Alzheimer's disease and mild cognitive impairment. Paper topics include tests of general cognition, visual, verbal and auditory tests, dementia subtypes, machine learning, and language and culturally adapted tests. Sections in this episode: General cognition (2:00) Visual, verbal, and auditory testing (13:50) Other dementia subtypes (18:43) Machine learning (25.08)Language and cultural adaptations (29.32)-------------------------------------------------------------- To access the folder with all the bibliographies for 2021 so far, follow this link (it will be updated as we p...2021-07-1433 min
AMiNDR: A Month in Neurodegenerative Disease Research177 - Treatments targeting Neurotransmitter Balance in Alzheimer's Disease: May 2021This episode of AMiNDR highlights literature published in May of 2021 that target neurotransmitter balance in Alzheimer's Disease. Greatest hits include cholinesterase inhibition, targeting glutamate excitotoxicity, and there's even a bonus paper on adrenergic transmission. Get excited! But maintain homeostasis. Sections in this episode: Targeting cholinesterases and oxidative stress (1.56) Targeting glutamate and excitotoxicity (22.33) Targeting Adrenergic Receptor (26.58) -------------------------------------------------------------- To access the folder with all the bibliographies for 2021 so far, follow this link (it will be updated as we publish episodes and process bibliographies), or click the following link be...2021-07-0930 min
AMiNDR: A Month in Neurodegenerative Disease Research176 - Familial Mutations, New Variants & Other Genetic Insights in Alzheimer's Disease: May 2021Wow - May 2021 is a productive month for AD genetics research! Tune in and Joseph will take you through 19 papers on studies to do with new variants, novel genetic insights, or studies on familial AD genetics. Sections in this episode: Methods for Gene and Pathway Discovery (1:46) GWAS, Transcriptome, Exome Sequencing (5:47) Miscellaneous (12:55) Familial AD (17:11) -------------------------------------------------------------- You can find the numbered bibliography for this episode by clicking here, or the link below:https://drive.google.com/file/d/1pKecrNPbkMwJyc_z7Yeo3P0frV...2021-07-0832 min
AMiNDR: A Month in Neurodegenerative Disease Research175 - Role of the Immune System & Glial Cells in Alzheimer's Disease: May 2021In this episode, Courtney takes you through the papers from May of 2021 on the Role of Immune systems and glial cells in Alzheimer's disease pathology! We will be discussing papers related to neuroinflammatory pathways in microglia and astrocytes, metabolism, peripheral inflammation and so much more! Tune in for this exciting episode! Sections in this episode: Microglia (02:07) Astrocytes (10:42) TREM2 (13:34) Metabolism (18:08) Periphery (24:53) -------------------------------------------------------------- You can find the numbered bibliography for this episode by clicking here, or the link below:https://drive.google.com/file/d/1...2021-07-0633 min
AMiNDR: A Month in Neurodegenerative Disease Research174 - Understanding Cognitive & Behavioural Changes in Alzheimer's Disease Part 2: May 2021In part 2 of this set of episodes, Ellen dives into papers on psychiatric changes and sleep disturbances in the context of AD. This includes research looking at depression, anxiety, agitation, circadian rhythm, and more in AD patients, animal models, and even clinical trials! There's sure to be something for everyone in this diverse set of papers, enjoy! Sections in this episode: Depression (2:27) Anxiety (5:26) Stress & PTSD (9:55) Agitation (13:30) Emotional Reactivity (17:13) Sleep & Circadian Rhythms (19:12) -------------------------------------------------------------- You can find the numbered bibliography for this episode by clicking...2021-07-0633 min
AMiNDR: A Month in Neurodegenerative Disease Research172 - Detection of Amyloid, Tau, and other PET Targets in Alzheimer's Disease: May 2021In this episode, we’ll take a closer look at 13 papers published in May 2021, that rely on Positron emission tomography imaging (or PET) to detect amyloid and tau pathology in the brain, within the context of Alzheimer’s disease! Make sure to take a listen if you’re interested in learning more about tau and amyloid based detection, alternative PET tracers in AD research, or combining PET with different imaging modalities. Sections in this episode: Tau Based Detection (1:48) A-beta Based Detection (10:45) Tau and A-beta (18:10) Other PET Targets (19:33) ...2021-07-0222 min
AMiNDR: A Month in Neurodegenerative Disease Research171 - Understanding Cognitive & Behavioural Changes in Alzheimer's Disease Part 1: May 2021In part one of this 2-parter, Ellen will tell you all about the latest studies on cognition and motor deficits in AD. This includes mechanistic studies, as well as studies looking at potential treatment avenues for these symptoms. We hope you enjoy, and stay tuned for part 2 coming out soon! Sections in this episode: Cognition in AD patients (4:09) Cognition in animal models (9:38) Motor impairments (19:00) ------------------------------------------------------------- PLEASE FILL OUR SURVEY TO HELP US IMPROVE OUR PODCAST, AND ENTER A DRAW FOR A $30 GIFT CARD. Link if you prefer...2021-07-0124 min
AMiNDR: A Month in Neurodegenerative Disease Research170 - Hemodynamics, Metabolic Changes & EEG in Alzheimer's Disease: May 2021From working memory tasks to mouse models, and even to lexical semantics, Judy goes over a wide range of papers that study AD diagnosis using a variety of neuroimaging techniques. Check out this episode if you're interested in hearing about changes in cerebral blood flow, metabolism and EEG signals in the context of AD. You're sure to learn something new! Sections in this episode: Hemodynamics (1:05) Metabolic Changes (9:45) EEG (16:30) ------------------------------------------------------------- PLEASE FILL OUR SURVEY TO HELP US IMPROVE OUR PODCAST, AND ENTER A DRAW FOR A $30 GIFT CARD. Link...2021-06-3024 min
AMiNDR: A Month in Neurodegenerative Disease Research167 - Vascular Contributions to Alzheimer Disease and Treatments Targeting the Vasculature: May 2021Elyn is back with more on all things vasculature! In this episode, she covers 14 papers that span many topics in the field of vascular contributions to Alzheimer disease - all the way from mechanisms linking cardiovascular and metabolic health to the Alzheimer pathology, to clinical studies associating cognitive symptoms with markers of cerebrovascular damage. Tune in to hear a perspective on AD that's outside of the amyloid cascade hypothesis! Sections in this episode:Overlap Between Cardiovascular Disease and AD (3:56)Clinical Studies on Cerebrovascular Pathology (12:20)Microvascular and Blood-Brain Barrier Changes i...2021-06-2534 min
AMiNDR: A Month in Neurodegenerative Disease Research166 - Imaging of Connectivity Changes in Alzheimer's Disease: May 2021Come join us as Judy covers all topics related to connectivity changes in Alzheimer's Disease. This episode features the latest research on both structural and functional connectivity using methods such as resting-state fMRI, DTI and EEG. Tune in to find out more! Sections in this episode: fMRI (2:00) MRI (10:51) Other (15:43) ------------------------------------------------------------- PLEASE FILL OUR SURVEY TO HELP US IMPROVE OUR PODCAST, AND ENTER A DRAW FOR A $30 GIFT CARD. Link if you prefer to copy/paste: https://amindr.hostedincanadasurveys.ca/417377?lang=enREGARDLESS...2021-06-2421 min
AMiNDR: A Month in Neurodegenerative Disease Research164 - Synaptic Transmission in Alzheimer's Disease: May 2021Ellen kicks off the May 2021 series with 20 papers all about synaptic transmission in Alzheimer's Disease. This includes topics like synaptic plasticity, neurotransmitters like acetylcholine, dopamine, and serotonin and how they're involved in AD, growth factors, morphological changes, and much more! Enjoy the show! Sections in this episode:Neurogenesis (5:11)Synaptic Plasticity (8:46)Neurotransmitter Signaling (18:26)Excitation/Inhibition Balance (28.07)Growth Factors (32:16)Morphological & Anatomical Changes (35:46)-------------------------------------------------------------- PLEASE FILL OUR SURVEY TO HELP US IMPROVE OUR PODCAST, AND ENTER A DRAW FOR A $30 GIFT CARD. ...2021-06-2245 min
AMiNDR: A Month in Neurodegenerative Disease Research158 - Clinical Markers of Alzheimer's Disease Part 1: March 2021In part 1 of the clinical markers of AD episodes, Ellen will tell you about papers from March 2021 all about cognition. This includes papers on new cognitive tests, improving or adapting old ones to new situations, learning more about how useful these different assessments really are, AND some really cool papers at the end on new technology and machine learning tools to make AD diagnosis and detection even better! Sections in this episode: Multi-Domain Cognitive Testing (3:16) Naming & Recall (11:41) Executive Function (17:06) Emotion Recognition (19:11) Amyloid-beta & Cognitive Decline (22:06) Machin...2021-05-2439 min
AMiNDR: A Month in Neurodegenerative Disease Research153 - Understanding Cognitive & Behavioural Changes in Alzheimer's Disease: March 2021Tune in as Ellen updates you on all things cognition and behaviour in Alzheimer's disease. Particularly, she'll tell you about new studies from March 2021 that shed light on the characteristics of cognitive and behavioural symptoms in AD, and the underlying neural mechanisms. This episode covers a lot of ground -- memory, executive function, the sense of smell, depression, chewing, and so much more! You're sure to learn a lot in this jam-packed episode. Sections in this episode: Characterizing Cognitive Changes in AD (2:27) Underlying Neuropathology of Cognitive Symptoms (8:23) Olfaction (15:28) Psyc...2021-05-1842 min
AMiNDR: A Month in Neurodegenerative Disease Research144 - Cognitive & Clinical Indicators of Alzheimer's Disease, Part 2: February 2021Ellen is bringing you Part 2 of our series on cognitive & clinical indicators to diagnose AD! Make sure to check out episode 143 for Part 1! In Part 2, you'll learn about the latest research validating old & new cognitive tests for AD and mild cognitive impairment, how motor and muscular symptoms can be used to diagnose AD, how body temperature relates to this disease, and the latest in machine learning technology to distinguish AD patients from cognitively normal individuals. Sections in this episode: Cognitive Assessments & Screening Tools (3:07) Motor & Muscular Deficits (16:00) Body Temperature (22:00) Mach...2021-04-2031 min
AMiNDR: A Month in Neurodegenerative Disease Research134 - Understanding Cognitive & Neuropsychiatric Changes in Alzheimer's Disease: February 2021A huge focus of Alzheimer's Disease research is understanding the mechanisms behind behavioural symptoms and how to treat them. In this episode, Ellen takes you through papers published in February on topics such as autobiographical memory, sex differences, decision-making, sensory processing, depression, sleep, and so much more! Sections in this episode: Cognition (2:43) Sensory processing (9:07) Gait disturbances (15:00) Psychiatric symptoms (18:22) Sleep (24:31) --------------------------------------------------------------You can find the bibliography for this episode by clicking here. To access the folder with all the bibliographies for 2021...2021-04-0830 min
AMiNDR: A Month in Neurodegenerative Disease Research117 - Understanding Cognitive & Neuropsychiatric Changes in Alzheimer's Disease: January 2021Ellen covers papers published this past January on cognitive and neuropsychiatric symptoms in AD and the mechanisms behind them. You'll hear about sensory processing, cognitive and memory deficits, psychiatric symptoms and emotions, and sleep and circadian rhythms in the context of AD. Tune in to learn about the potential mechanisms behind these symptoms, and how they correspond to disease progression. Sections in this episode: Sensory Processing (Olfaction, Vision, and Pain) (3:41) Cognition & Memory (13:32) Psychiatric Symptoms & Emotions (18:37) Sleep & Circadian Rhythms (23:35) ------------------------------------------------------------------ Click here to see the li...2021-03-0631 min
AMiNDR: A Month in Neurodegenerative Disease Research116 - Treatments targeting the Immune System, Glia, Proteostasis & Autophagy in Alzheimer's Disease: January 2021 In this episode, Abdullah will cover the latest papers from January 2021 covering development of potential treatments targeting glia, immune cells, proteostasis and autophagy. Tune in to learn about out-of-the-box ideas like how rotten eggs and silver apricots may hold therapeutic benefits for Alzheimer's Disease. Sections in the episode: Microglia (3:46) Astrocytes (7:17) Glial cells in general (11:43) Proteostasis & Autophagy (22:49) ------------------------------------------------------------------ To access the folder with the bibliographies for the month of January, follow this link (it will be updated as we publish episodes and process bibliograph...2021-03-0529 min
AMiNDR: A Month in Neurodegenerative Disease Research111 - Mechanisms of Synaptic Transmission in Alzheimer's Disease: January 2021In this episode, Glory will take you through the papers published on alterations to synaptic transmission and structure in Alzheimer's disease from January 2021. Tune in for all things synaptic - including glutamate receptor signalling, long-term potentiation and dendritic spine integrity! Sections in this episode: Neurotransmitter signaling: 1.45 Synaptic plasticity: 13.55 Synapse structure: 16.40 Memory: 19.20 ------------------------------------------------------------------ Click here to see the list of papers covered in this episode.To access the folder with the bibliographies for the month of January, follow this link (it will be updated as we publi...2021-02-2622 min
AMiNDR: A Month in Neurodegenerative Disease ResearchSPECIAL: ONE YEAR WITH AMINDR!What role does social media play in academia and science communication nowadays? How can we keep our biases from interfering with fair reporting and objective coverage? Do we need to revise our inclusion criteria for the papers we cover? How relevant is the categorization of research by disease when there is so much overlap in underlying mechanisms? And how much responsibility do we hold through our podcast in shaping people’s understanding of these papers?Today you will hear from Sarah Louadi, Ellen Koch, Elyn Rowe, and Naila Kuhlmann, for a special celebratory episode for our anniversary. Tha...2020-11-151h 07
AMiNDR: A Month in Neurodegenerative Disease ResearchSPECIAL: ONE YEAR WITH AMINDR!What role does social media play in academia nowadays? How can we keep our biases from interfering with fair reporting and objective coverage? Do we need to revise our inclusion criteria for the papers we cover? How relevant is the categorization of research by disease when there is so much overlap in underlying mechanisms? And how much responsibility do we hold through our podcast in shaping people’s understanding of these papers?Today you will hear from Sarah Louadi, Ellen Koch, Elyn Rowe, and Naila Kuhlmann, for a special celebratory episode for our anniversary. That’s right, Novem...2020-11-141h 07
AMiNDR: A Month in Neurodegenerative Disease Research51 - Cognitive Testing for Diagnosis: Alzheimer's Disease August 2020Ellen tells you about the latest papers on cognitive testing for AD and mild cognitive impairment! This includes papers that delve deeper into how cognition is affected in AD and other disorders, and in some cases compare these changes to neurological data. Other papers validate existing cognitive assessment tools, or describe brand new ones, including new analysis algorithms and computer-based testing. Enjoy the episode! ------------------------------------------------------------------ To receive the list of papers covered, please fill this form: --------> https://forms.gle/CVVbznAFM8pamdgk6 ------- or by tweeting at us: @AMiNDR_podcast ...2020-11-1335 min
AMiNDR: A Month in Neurodegenerative Disease Research44 - Preclinical Testing Part 2: Alzheimer's Disease August 2020You'll hear about some big topics in Alzheimer's disease research in this episode! Ellen covers all of the pre-clinical studies from August 2020 testing potential new treatments targeting neuroinflammation, oxidative stress, mitochondria, metabolism, and lipids. This is the second part of three pre-clinical testing episodes this month, check out episode #42 for part 1, and look out for part 3, coming soon!------------------------------------------------------------------ To receive the list of papers covered, please fill this form: --------> https://forms.gle/CVVbznAFM8pamdgk6 ------- or by tweeting at us: @AMiNDR_podcast ------------------------------------------------------------------ We would appreci...2020-11-0936 min
AMiNDR: A Month in Neurodegenerative Disease Research34 - Detecting Amyloid & Tau in the brain: Alzheimer's Disease June 2020Having trouble keeping up with the literature in Alzheimer's Disease? We are here to help! Ellen tells you about the papers on amyloid and tau detection in the brain, from June 2020! This includes studies on PET imaging in humans, PET and MRI imaging in animals, developing fluorescent and antibody probes, and more! Very interesting stuff, we hope you enjoy. This episode finishes off our series covering the papers in June 2020! ------------------------------------------------------------------ To receive the list of papers covered (with timestamps), please fill this form: --------> https://forms.gle/CVVbznAFM8pamdgk6 ------- or...2020-10-1923 min
AMiNDR: A Month in Neurodegenerative Disease ResearchNovel Drug Development-Part 2: Alzheimer's Disease June 2020Having trouble keeping up with the literature in Alzheimer's Disease? We are here to help! Ellen tells you about more papers on drugs in development from June 2020. These studies encompass those done in vitro or using computational models, but not animal testing. This time around, she will be focusing on papers where the target is tau protein, the cholinergic system, metabolism, mitochondria, neuroinflammation, and autophagy from June 2020! If you're interested in hearing more about treatments for AD, you should also check out our episodes on pre-clinical and clinical testing. To receive the list of p...2020-09-1333 min
AMiNDR: A Month in Neurodegenerative Disease ResearchCognitive/Behavioural Testing & Unclassified Detection Methods: Alzheimer's Disease June 2020Having trouble keeping up with the literature in Alzheimer's Disease? We are here to help! In this episode, Ellen starts by updating you on the latest papers on cognitive and behavioural testing for the detection or diagnosis of AD. Then, she moves on to papers we sorted under Unclassified Detection methods. Enjoy!To receive the list of papers covered (with timestamps), please fill this form: -------> https://forms.gle/CVVbznAFM8pamdgk6 -------or by tweeting at us: @AMiNDR_podcast--------------------------------------------------------------------List of sections in this epis...2020-08-1242 min
AMiNDR: A Month in Neurodegenerative Disease ResearchCognitive Changes & Synaptic Transmission: Alzheimer's Disease June 2020Having trouble keeping up with the literature in Alzheimer's Disease? We are here to help! In this episode, we cover the papers published in June 2020 about cognitive changes and synaptic transmission in Alzheimer's disease. You get 2 for 1! To receive the list of papers covered (with time-stamps), please subscribe to our mailing list. You can do so by filling this form: --------> https://forms.gle/CVVbznAFM8pamdgk6 -------or by sending us an email at ---------> amindrpodcast@gmail.com-----------------------------------------------------------------------List of sections in this episode: Cognitive...2020-07-2923 min