Shows
AMiNDR: A Month in Neurodegenerative Disease Research339 - Treatments Targeting Neuroprotection in Alzheimer's DiseaseAnother series of AMiNDR kicks off with this episode. Anusha takes you through 7 papers published in January 2024 targeting neuroprotection in AD. If you'd like to hear about potential compounds that could reduce neurodegeneration in Alzheimer's disease, this is the episode for you.Testing for neuroprotection in cell lines (2:57)Testing for neuroprotection using in vivo AD models (11:47)-------------------------------------------------------------- You can find the bibliography for this episode here, or by clicking the link below:https://drive.google.com/file/d/1A4HZVCtgh5AwZkd5V2ATZSFAxGJt48q3/view?usp=drive_linkT...2024-03-2619 min
AMiNDR: A Month in Neurodegenerative Disease Research338 - Interview with Joseph Liang - Navigating The Journey To (And Through) Graduate SchoolAnother special episode to help kick off our return! In what we hope to be a recurring special series, an interview with members in our scholarly community on navigating the multiple facets of life as a scientist. In the first episode, host Kevin Nishimura interviews one of our own Joseph Liang on his personal journey to and through graduate school. Tune in to learn what he has to say about getting into graduate school, and how his perspective on the journey has changed since he's started! We hope you enjoy, and please let us know if you want to...2024-02-2024 min
AMiNDR: A Month in Neurodegenerative Disease Research337 - Prevention & Intervention Strategies for ADIn today's episode, Naila provides an overview of 14 articles published in November 2023 on non-pharmacological interventions for AD. You'll hear about cognitive training, music therapy, chair yoga, providing support to caregivers, and a range of neural stimulation techniques. Enjoy! Cognitive and Social Factors (2:26)Lifestyle interventions (13:40)Stimulation Techniques (19:20)-------------------------------------------------------------- You can find the bibliography for this episode here, or by clicking the link below:https://drive.google.com/file/d/1A4HZVCtgh5AwZkd5V2ATZSFAxGJt48q3/view?usp=drive_linkTo access the folder with AL...2024-02-1429 min
AMiNDR: A Month in Neurodegenerative Disease Research336 - Treatments Targeting Cholinergic Neurotransmission in ADJoin us as we cover a set of papers published in November 2023 on treatments targeting cholinergic transmission in Alzheimer's disease. In this episode hosted by Christy, we will go over various topics, from drug discovery using synthesized compounds to drug testing of plant extracts, as well as improving drug delivery through the blood-brain barrier. Enjoy! Papers evaluating synthesized compounds (2:00) Papers targeting AchE (10:45)-------------------------------------------------------------- You can find the bibliography for this episode here, or by clicking the link below:https://drive.google.com/file/d/1wh1EFtB3KrW0J6C...2024-02-0629 min
AMiNDR: A Month in Neurodegenerative Disease Research323 - The Immune System & Glia in Alzheimer's Disease Part 1: November 2022Welcome our new host, Anelya, who covers 12 papers on the role of immune system and glia in Alzheimer’s disease. The first half of this episode will focus on potential targets for the treatment of Alzheimer’s disease, followed by the disease-associated inflammatory mechanisms. Part 2 will be released as a bibliography. We hope you find this episode interesting! Sections in this episode: Potential Therapeutic Agents (2:28) Disease-Associated Neuroinflammatory Mechanisms (14:08) -------------------------------------------------------------- To find the numbered bibliography with all the papers covered in this episode, click here, or use the link below:http...2023-03-0927 min
AMiNDR: A Month in Neurodegenerative Disease Research322 - Functional Connectivity & Imaging in Alzheimer's Disease: November 2022Ellen brings you summaries of 8 abstracts from November 2022, all about functional connectivity and imaging in the context of Alzheimer's disease. There are a variety of brain regions covered in today's episode, including cortical regions, subcortical structures, and the hippocampus. Spanning studies in both humans and animals, this episode is sure to have something of interest to you and your research! Sections in this episode: Cortical regions (3:39) Subcortical forebrain regions (8:57) Hippocampus (14:30) -------------------------------------------------------------- To find the numbered bibliography with all the papers covered in this episode, click here, or use th...2023-03-0721 min
AMiNDR: A Month in Neurodegenerative Disease Research320 - Treatments Targeting Neuroprotection in Alzheimer's Disease: November 2022In this episode, Anusha guides you through 11 papers that were published in November of 2022. These papers study the efficacy of treatments targeting neuroprotection in Alzheimer's Disease models. Tune in if you want to be on the cutting edge of drug discovery and development in the field of AD. Sections in this episode: Drug Discovery and Development of Novel Therapeutics (3:49) Testing Existing Compounds (17:27) -------------------------------------------------------------- To find the numbered bibliography with all the papers covered in this episode, click here, or use the link below:https://drive.google.com/file...2023-02-2325 min
AMiNDR: A Month in Neurodegenerative Disease Research319 - Cognitive & Behavioural Changes in Alzheimer's Disease Part 1: November 2022Judy is so excited to take you through part 1 of the behavioural and cognitive changes in AD episode (part 2 will be released as a bibliography). This shorter episode features standard motor symptoms like impaired exercise and grip strength, as well as some less studied behavioural changes such as adverse driving in AD. You don’t want to miss this one! Sections in this episode: Behavioural Changes (3:30) Learning History (13:45) Depressive Symptoms (15:32) -------------------------------------------------------------- To find the numbered bibliography with all the papers covered in this episode, click here, or use the...2023-02-2120 min
AMiNDR: A Month in Neurodegenerative Disease Research318 - Synaptic Transmission in Alzheimer's Disease: November 2022Ellen kicks off the November 2022 series with 11 papers about synaptic transmission and neurotransmitters in Alzheimer's disease. Hear about glutamate, acetylcholine, synaptic proteins, and more in this jam-packed episode! Sections in this episode: Glutamate and Acetylcholine (4:01) GABA neurons (10:52) Neuron Excitability (12:15) Synaptic Proteins (15:10) Neuro-Immuno-Endocrine System (21:45) -------------------------------------------------------------- To find the numbered bibliography with all the papers covered in this episode, click here, or use the link below:https://drive.google.com/file/d/1dELth-9F_TVyUTuxPmuIVYKM1MgCuIEf/view?usp=share_linkTo access t...2023-02-1626 min
AMiNDR: A Month in Neurodegenerative Disease Research317 - Functional Connectivity & Imaging in Alzheimer's Disease: October 2022Today, we talk all about neuroimaging, with 7 papers that use various imaging modalities in humans, animals, and computational modeling, to study how the brain changes in Alzheimer’s disease. Tune in to learn more! Sections in this episode: Hippocampus (3:50) Hypothalamus (8:15) Cortical regions (10:29) Nucleus basalis (15:57) Pineal gland (18:40) -------------------------------------------------------------- To find the numbered bibliography with all the papers covered in this episode, click here, or use the link below:https://drive.google.com/file/d/1I3kmmULxiu1EG1CoEtIMsFQzZIs8zSbO/view?usp=share_link2023-01-2723 min
AMiNDR: A Month in Neurodegenerative Disease Research313 - Synaptic Transmission in Alzheimer's Disease: October 2022Kick off the new year with Ellen, who tells you all about synaptic transmission in Alzheimer's disease in this episode. You'll hear about 5 papers published in October of 2022 on synaptic transmission, ranging from research on whole brain networks all the way down to individual proteins. -------------------------------------------------------------- To access the numbered bibliography for this episode, click here, or use the link below:https://drive.google.com/file/d/1sIxUDc8NrG6HAXL9ikKCCGx6KgX--ULp/view?usp=share_linkTo access the folder with ALL our bibliographies, follow this link (it will be updated as...2023-01-1213 min
AMiNDR: A Month in Neurodegenerative Disease Research311 - Understanding APOE: August 2022In this month's episode of AMiNDR, Cassi recaps papers on APOE published in August 2022. Cassi just defended her dissertation where she studied immunometabolism in the context of APOE. She starts with cells, moves to mice, and finishes with human research studies. -------------------------------------------------------------- To find the numbered bibliography with all the papers covered in this episode, click here, or use the link below:https://drive.google.com/file/d/11pGVGJGUWfPNAqJ-Jw7cUGyUGb_HRXwy/view?usp=drivesdkTo access the folder with ALL our bibliographies, follow this link (it will be updated as we pu...2022-12-2228 min
AMiNDR: A Month in Neurodegenerative Disease Research310 - Cognitive and Behavioural Changes in Alzheimer's Disease: August 2022Today, we have papers on behavioural and cognitive changes in Alzheimer’s disease. We’ve got our usual sections such as rodent models and sleep, but we also have some new topics, including cognitive reserve and even a paper on virtual reality. You’re in for a treat!Sections in this episode: Behavioural Changes (2:28) Cognitive Changes (11:10) -------------------------------------------------------------- To access the folder with ALL our bibliographies, follow this link (it will be updated as we publish episodes and process bibliographies), or use the link below:https://drive.google.com/drive...2022-12-1520 min
AMiNDR: A Month in Neurodegenerative Disease Research308 - Synaptic Transmission in Alzheimer's Disease: August 2022To kick off our series on August papers, we will talk all about different ways that synaptic transmission may be affected in Alzheimer's disease, with 6 research papers that use either cell models, animal models, or human patients. Stay tuned! Sections in this episode: Cortical signaling in rodent models (3:15) New AD models (8:32) Biomarkers of neural dysfunction in humans (9:24) -------------------------------------------------------------- To find the numbered bibliography with all the papers covered in this episode, click here, or use the link below:https://drive.google.com/file/d/1iLzCzMAIoIYq7fW_zJ2...2022-12-0816 min
AMiNDR: A Month in Neurodegenerative Disease Research307 - Cognitive & Behavioural Changes in Alzheimer's Disease Part 2: July 2022In Part 2 of Cognitive and Behavioural Changes, Naila covers 8 papers on neuropsychiatric, social and cognitive symptoms linked to Alzheimer's disease, and their implications for diagnosis and disease management. You'll learn about the links between AD and depression, the importance of social networks, and machine learning methods for identifying important lifestyle information from clinical notes. Enjoy! Neuropsychiatric Changes (2:11)Cognitive Changes (10:25)Statistics and Machine Learning (17:05)-------------------------------------------------------------- To find the numbered bibliography with all the papers covered in this episode, click here, or use the link below:https://dr...2022-11-0423 min
AMiNDR: A Month in Neurodegenerative Disease Research305 - Treatments Targeting Neuroprotection in Alzheimer's Disease: July 2022This is an episode all about targeting synaptic and neuronal heath in Alzheimer's disease. Anusha will cover in silico, in vitro, and in vivo studies of candidate compounds that target neuroprotection and neurogenesis. Be sure to check out this paper to stay up to day on the latest preclinical therapeutics being tested. Sections in this episode: In silico and treatment development (3:24) Targeting Neurogenesis (7:07) Targeting Neuroprotection (12:00) -------------------------------------------------------------- To find the numbered bibliography with all the papers covered in this episode, click here, or use the link below:http...2022-10-2726 min
AMiNDR: A Month in Neurodegenerative Disease Research301 - Synaptic Transmission in Alzheimer's Disease: July 2022We are kicking off our July 2022 series of AMiNDR with this episode and are so glad you are tuning in. If you’re interested in changes to neuronal function in AD, we’ll be covering the entire spectrum in this episode. Starting big with network changes, we scale all the way down to molecular changes that may underlie AD pathology, so if that’s what you’re interested in, stay tuned! Sections in this episode: Special Mention of Blots in a Field? (3:39) Network Dysfunction (4:53) Synaptic Dysfunction (12:09) Molecular Changes (22:33) ...2022-10-1230 min
AMiNDR: A Month in Neurodegenerative Disease Research292 - Synaptic Transmission in Alzheimer's Disease: June 2022We are kicking off our June 2022 series of episodes with this short and sweet episode. Anusha takes a look at papers published on the subject of changes to synaptic transmission and neuronal excitability in Alzheimer’s disease. If you're interested in bridging the gap between changes to neuronal function and behavioural consequences, this episode is a great place to start! Sections in this episode: Changes to neurotransmission and neuronal excitability (2.44) Changes to movement/learning and memory (11.06) -------------------------------------------------------------- To find the numbered bibliography with all the papers covered in this episode...2022-08-2317 min
AMiNDR: A Month in Neurodegenerative Disease Research290 - Treatments Targeting Neuroprotection in Alzheimer's Disease: May 2022Anusha is excited to guide you through 12 papers published in May of 2022 that all test different treatment options for Alzheimer’s disease, preclinically. She will cover topics like discovery and development of agents that confer neuronal and synaptic protection or target neuronal function directly. This episode is sure to leave you feeling hopeful about future therapeutic directions! Drug Discovery/Development (1:52)Targeting Neuronal Functions (9:19)Targeting Neuroprotection (14:25) -------------------------------------------------------------- To find the numbered bibliography with all the papers covered in this episode, click here, or use the li...2022-07-2922 min
AMiNDR: A Month in Neurodegenerative Disease Research289 - Cognitive and Behavioural Changes in Alzheimer's Disease: May 2022In this exciting episode, Judy goes over papers published in May 2022 on the latest research involving cognitive, behavioural and clinical changes in AD. Subjects include sensory processing, mouse models, sleep, and many more! Sensory Processing (1:45)Mouse Models (5:44)Clinical Treatments (8:34)Sleep (12:59)Other (17:29) -------------------------------------------------------------- To find the numbered bibliography with all the papers covered in this episode, click here, or use the link below: https://drive.google.com/file/d/1yY6gR2c2e_Big8_Atx_VVb2RqCw6P...2022-07-2725 min
AMiNDR: A Month in Neurodegenerative Disease Research288 - New Variants and Genetic Insights Part 1: May 2022In this episode, Joseph is back to go over papers published in May 2022 on GWASs, genetics or any other genetics-focused work. Topics include GWAS's, tool development, gene discovery, and social performance-based genetic studies! GWAS and Polygenic Risk Scores (2:20)Cognitive & Social Genetic Studies (8:42)Tool development (11:46)Gene Discovery (14:41)Studies on Amyloid and Tau (16:09) -------------------------------------------------------------- To find the numbered bibliography with all the papers covered in this episode, click here, or use the link below: https://drive.google.com...2022-07-2522 min
AMiNDR: A Month in Neurodegenerative Disease Research287 - Cognitive Assessment in Alzheimer's Disease: May 2022Welcome welcome! This episode was made for you if you are interested in geriatrics, neurology, or cognitive testing in general, as we will go through the latest publication on clinical assessment of cognitive decline. That’s right, 9 papers published in May 2022 on testing neurocognitive domains for the screening or diagnosis of mild cognitive impairment, Alzheimer’s disease, or dementia in general. Learning and Memory (7:17)Perceptual and Motor Skills (20:23)Language (22:33)Activities of Daily Living (27:56) -------------------------------------------------------------- To find the numbered bibliography with all the paper...2022-07-2236 min
AMiNDR: A Month in Neurodegenerative Disease Research286 - Synaptic Transmission in Alzheimer's Disease: May 2022AMiNDR is back and excited to bring you more literature on Alzheimer’s Disease. In this episode, we’ve got papers published in May of 2022 on the subject of changes to synaptic transmission and neuronal excitability. Anusha covers subjects like calcium homeostasis, synaptic function, and how to translate findings to humans and human models, so join her if your neurons are excited by the topic! Sections in this episode: Calcium Homeostasis (2:54) Synaptic Function in Animal Models (5:26) Human Models (10:28) -------------------------------------------------------------- To find the numbered bibliograph...2022-07-2016 min
AMiNDR: A Month in Neurodegenerative Disease Research282 - Treatments Targeting Neuroprotection in Alzheimer's Disease: March 2022Another 12 papers published in March of 2022 awaits you. This episode is all about treatments that target neuroprotection to treat AD. The papers model it by inducing cytotoxicity in the brain, either with molecules like amyloid beta or genetic mutations. Anusha is excited to guide you through promising treatment options, are you excited too? Sections in this episode: Stem Cell-Based Therapy (3.01) Testing compounds in A-Beta AD Models (4.52) Testing compounds in APP/PS1 AD Model (14.49) Test compounds in other AD Models (17.15) -------------------------------------------------------------- To find the numbered bibliography with al...2022-05-2622 min
AMiNDR: A Month in Neurodegenerative Disease Research281 - Synaptic Transmission in Alzheimer's Disease: March 2022Ease in to our March 2022 series with 8 papers published on the subject of synaptic transmission in Alzheimer's Disease. Anusha will highlight changes to connectivity and ones caused by APP and Tau proteins so check out this episode to bridge the communication gap in your brain too! Sections in this episode: Synaptic Connectivity Changes (1.44) APP/Tau contribution to Synaptic Dysfunction (7.47) -------------------------------------------------------------- To find the numbered bibliography with all the papers covered in this episode, click here, or use the link below:https://drive.google.com/file/d/1BY9b9lZ7...2022-05-2418 min
AMiNDR: A Month in Neurodegenerative Disease Research280 - Treatments Targeting Neuroprotection in Alzheimer's Disease: February 2022In February of 2022, 8 papers were published on the topic of using neuroprotective compounds as treatment for AD. Anusha will guide you through these papers exploring the entire drug discovery pipeline, from discovery to clinical trials. Sections in this episode: Drug Discovery (2.01) Drug Development (4.59) Clinical Trials (11.58) -------------------------------------------------------------- To find the numbered bibliography with all the papers covered in this episode, click here, or use the link below:https://drive.google.com/file/d/1zzsck-2adMbZB8_cYV6B-AyOwd2p_gqt/view?usp=sharingTo access the fo...2022-04-3017 min
AMiNDR: A Month in Neurodegenerative Disease Research273 - Risk Factors for Alzheimer's Disease Part 2: January 2022In Part 2 of epidemiological studies published in January 2022, we'll focus on the association between cardiovascular health, diabetes and Alzheimer's disease. Naila will guide you through the latest research on how things like blood pressure, body mass index and insulin resistance are related to dementia and to AD pathology. Sections in this episode: Cardiovascular Factors (2:35) BMI (12:25) Diabetes and Related Conditions (14:49) -------------------------------------------------------------- To find the numbered bibliography with all the papers covered in this episode, click here, or use the link below:https://drive.google.com/file/d/1pES...2022-04-0528 min
AMiNDR: A Month in Neurodegenerative Disease Research270 - Treatments Targeting Neuroprotection in Alzheimer's Disease: January 2022Pssst. Did you hear that 14 papers were published in January of 2022 on treatments targeting synaptic and neuronal protection in Alzheimer's disease? Anusha has you covered with papers targeting amyloid-beta-induced cytotoxocity, demyelination, and cognitive dysfunction in animal models. Sections in this episode: Treatments using stem cells (2.18) Protecting against A-beta induced toxicity (4.59) Protecting against glutamate-induced cytotoxicity (9.20) Treatments tested in transgenic AD-like mice (12.38) Treatments tested in AD rat models (17.13) -------------------------------------------------------------- To find the numbered bibliography with all the papers covered in this episode, click here, or use the...2022-03-2626 min
AMiNDR: A Month in Neurodegenerative Disease Research269 - Structural Changes in the Brain in Alzheimer's Disease: January 2022What information do grey and white matter tell us about mild cognitive impairment vs. Alzheimer's disease? Enjoy this episode in which Christy goes over study findings from 12 papers published in January 2022 on the topic of structural brain changes related to AD. Sections in this episode: Gray and white matter changes (2.25) Correlations of structural changes with biomarkers (9.28) Methods for early detection (15.27) Software packages for brain volumetry (19.03) Radiomic (22.56) -------------------------------------------------------------- To find the numbered bibliography with all the papers covered in this episode, click here, or use the...2022-03-2428 min
AMiNDR: A Month in Neurodegenerative Disease Research266 - Risk Factors for Alzheimer's Disease: December 2021Discover the latest on risk and protective factors of AD, from the perspective of 18 observational studies published in December 2021. Naila will take you through socioeconomic factors, nutrition, exercise, and various comorbidities related to AD. Sections in this episode: Prevalence and Socioeconomic Factors (1:45) Nutrition (13:11) Health-Related Factors (18:49) -------------------------------------------------------------- To find the numbered bibliography with all the papers covered in this episode, click here, or use the link below:https://drive.google.com/file/d/15gMFkpU55HqCYCSQMYvaVgVngdY9j8DT/view?usp=sharingTo access the folder with a...2022-03-0836 min
AMiNDR: A Month in Neurodegenerative Disease Research265 - Treatments Targeting Neuroprotection in Alzheimer's Disease: December 2021In this short and sweet episode, Anusha will take you through 7 papers published in December of 2021 on the subject of treatments targeting neuronal and synaptic protection in AD. Exercise your cognitive reserve by tuning into this episode! Sections in this episode: Testing Naturally-Derived Compounds (3.35) Testing Pre-Existing Drugs (10.54) -------------------------------------------------------------- To find the numbered bibliography with all the papers covered in this episode, click here, or use the link below:https://drive.google.com/file/d/1Hiyw6KCbidwmpO12pL1unqbHOJYSLbDd/view?usp=sharingTo access the folder with...2022-03-0219 min
AMiNDR: A Month in Neurodegenerative Disease Research263 - Vascular Contributions to Alzheimer's Disease: December 2021Tired of the amyloid cascade hypothesis? Think there's more to AD than the plaques and tangles? You've come to the right place! Elyn is back for her final episode covering papers from 2021 on Vascular Contributions to Alzheimer Disease. Tune in to hear about the latest findings relating to cerebrovascular changes in AD, and why they matter. Sections in this episode: Insights from Clinical Studies (4:10) Insights from Animal Models (14:47) -------------------------------------------------------------- To find the numbered bibliography with all the papers covered in this episode, click here, or use the link below:...2022-02-2424 min
AMiNDR: A Month in Neurodegenerative Disease Research262 - Prevention and Intervention Strategies for Alzheimer's Disease: December 2021In today's episode, Naila will take you through 11 studies from December 2021 on different non-pharmacological methods for treating Alzheimer's disease. You'll hear the latest research on the importance of sleep, how cognitive training might reduce Alzheimer's pathology, and numerous stimulation techniques for improving cognitive function in people with AD. Enjoy! Sections in this episode: Cognition and Sleep (1.34) Exercise (6.28) Neuromodulatory Techniques (12.16)-------------------------------------------------------------- To find the numbered bibliography with all the papers covered in this episode, click here, or use the link below:https://drive.google.com/file/d/1EK...2022-02-2227 min
AMiNDR: A Month in Neurodegenerative Disease Research261 - Clinical Assessment in Alzheimer's Disease Part 2: December 2021This episode of AMiNDR is part 2 of our Clinical Assessment series. Today, you'll hear about new cognitive tests and advancements in existing tools for clinical testing. With every new study on Alzheimer’s disease, we are one step closer to understanding this disease better, diagnosing people faster, and helping people more effectively. Get ready to hear about some of the latest ways that scientists and clinicians are getting us closer to these goals! Sections in this episode: New or Updated Assessment Tools (4:56) Evaluating Existing Tools (12:50) Cognition in Specific Populations (17:18) ...2022-02-1923 min
AMiNDR: A Month in Neurodegenerative Disease Research260 - Clinical Assessment in Alzheimer's Disease Part 1: December 2021Can smell, gaze, blinking rate, or handwriting offer a window into what happens inside the Alzheimer’s disease brain? Are there parameters we can add to our batteries for assessing cognitive decline in a clinical setting? Missed opportunities in cognitive assessment? Maybe. This episode is dedicated to all kinds of variables that can help orient ourselves on the Alzheimer’s disease continuum, and perhaps predict the progression from MCI to AD. Sections in this episode: Non-Cognitive Variables (6.27) Cognitive Variables (20.28) -------------------------------------------------------------- To find the numbered bibliography with all the papers covered i...2022-02-1830 min
AMiNDR: A Month in Neurodegenerative Disease Research259 - Changes to Synaptic Transmission in Alzheimer's Disease: December 2021Could changes to synaptic transmission underlie Alzheimer's disease pathology? Anusha has 8 papers to help you answer that question. These papers assess changes in humans, human models, and animal models and were all published in December of 2021. Sections in this episode: Changes in Neuronal Activity in Humans and Human Models (2.50) Changes in Neurogenesis in APP/PS1 Transgenic AD Mice (10.08) Changes in Neuronal Activity in APP/PS1 Transgenic AD Mice (13.42) -------------------------------------------------------------- To find the numbered bibliography with all the papers covered in this episode, click here, or use the link b...2022-02-1720 min
AMiNDR: A Month in Neurodegenerative Disease Research258 - Cognitive & Behavioural Changes in Alzheimer's Disease: December 2021To kick off this series, Ellen tells you about 17 studies published in December 2021 on how different forms of cognition, sensory processing, and psychiatric health can be affected in Alzheimer's disease, as well as papers exploring new treatment options! If you are an Alzheimer's researcher, or are just interested in hearing about the latest progress in this field, you don't want to miss this episode! Sections in this episode: Sensory Function & Processing (3:38) Emotional Processing (9:24) Language (11:15) Future Thinking (13:21) Preclinical Testing in AD Models (14:38) Comparing Different Diseases (21:09) Clinic...2022-02-1535 min
AMiNDR: A Month in Neurodegenerative Disease Research257 - Risk Factors for Alzheimer's Disease: November 2021Naila's back with 19 epidemiological and observational studies published in November 2021. It's quite the panoply of topics - you'll hear about marital status, air pollution, metabolic syndrome, medication use and more. We hope you enjoy! Sections in this episode: Epidemiological and Environmental (1.44) Vaccine/Medication Use (15.10) Psychomotor (22.48) Metabolic Comorbidities (26.18) Other Comorbidities (31.11) -------------------------------------------------------------- To find the numbered bibliography with all the papers covered in this episode, click here, or use the link below:https://drive.google.com/file/d/1Sv1PUzE2PV2lppDwY2-lPMTReLWaPux5/view?usp...2022-02-1039 min
AMiNDR: A Month in Neurodegenerative Disease Research255 - Treatments Targeting Neuroprotection and Neurotransmission in Alzheimer's Disease: November 202117 papers have "Targeting neurotransmission and synaptic dysfunction in AD" written all over it. Figuratively speaking of course. Anusha covers topics like targeting neurotoxicity and calcium flux, or acetylcholine transmission and balance, or even targeting monoamine oxidases to improve AD-like pathology. Better yet, this episode lets you keep up to date as all the papers were published in November of 2021. Sections in this episode: Targeting synaptic dysfunction (2.34) Targeting M1 acetylcholine receptors (14.03) Targeting cholinesterases by modifying existing drugs (17.32) Targeting cholinesterases with novel drugs (22.49) Targeting monoamine oxidases (27.31) -------------------------------------------------------------- To...2022-02-0432 min
AMiNDR: A Month in Neurodegenerative Disease Research254 - Tau Protein Pathology in Alzheimer's Disease: November 2021Join Kate for a comprehensive summary of everything tau from papers published in November 2021. We'll talk post-translational modifications, prion-like seeding pathology, molecular modeling, and even touch on a potential AD therapies targeting this fascinating little microtubule helper. Enjoy! :) Sections in this episode: Tau Aggregation and Post-Translational Modifications (03:03) Tau Seeding and General Tau Pathology (12:49) Novel Therapeutics (22:58) -------------------------------------------------------------- To find the numbered bibliography with all the papers covered in this episode, click here, or use the link below:https://drive.google.com/file/d/1bN5cizXqwbfTb-zaQsSckYjMcyz75kzF/view?us...2022-02-0330 min
AMiNDR: A Month in Neurodegenerative Disease Research253 - Vascular Contributions to Alzheimer's Disease: November 2021Interested in a fresh perspective on the etiology of AD? Join Elyn for her monthly tour through the new research on vascular contributions to Alzheimer disease! Whether this is your niche field, or you want to look at the disease through a new lens, this episode is perfect for you. Tune in to hear about endothelial cell biology, a phase 2 clinical trial, and several animal models! Sections in this episode: Endothelial Cell Biology & Amyloid Clearance (4:40) Insights from Animal Models (8:44) Insights from Human Studies (13:49) -------------------------------------------------------------- To find the number...2022-01-3123 min
AMiNDR: A Month in Neurodegenerative Disease Research252 - Clinical Assessment of Alzheimer's Disease: November 2021Welcome all researchers, students, and clinicians who are interested in learning about clinical testing for Alzheimer’s disease! This episode is dedicated to papers published back in November 2021 on new and old assessment methods to help in the diagnosis of Alzheimer’s. This includes testing cognitive processes and performance on activities of daily living, detecting Alzheimer’s, and distinguishing it from other dementias. You will hear about some new cognitive and non-cognitive parameters to consider as well, so tune in for your monthly fill of news in the field! Sections in this episode: Existing cognitive tests (7...2022-01-2937 min
AMiNDR: A Month in Neurodegenerative Disease Research251 - Prevention & Interventions for Alzheimer's Disease: November 2021In today's episode, Naila will guide you through 10 papers that were published in November 2021 on preventing and treating Alzheimer's disease. You'll hear about snoring, caffeine consumption, the mechanisms underlying exercise, and a bunch of neuromodulatory techniques that could treat certain aspects of AD. Hopefully you'll find this latest research to be stimulating! Sections in this episode: Modifiable Risk Factors (2:02) Neuromodulatory Techniques (8:55) -------------------------------------------------------------- To find the numbered bibliography with all the papers covered in this episode, click here, or use the link below:https://drive.google.com/file/d/1oP...2022-01-2725 min
AMiNDR: A Month in Neurodegenerative Disease Research250 - Changes to Synaptic Transmission in Alzheimer's Disease: November 2021You have just entered the magical world of Alzheimer’s literature. You are about to experience 8 papers that do their best to better understand the changes in synaptic transmission in Alzheimer’s disease. Where did we find such curious abstracts you ask? It just so happens that these were all papers published in November of 2021. Ready to go? Close your eyes and let Anusha be your guide through this journey of curiosity. Sections in this episode: Synaptic Changes in AD Mouse Models (2.27) AD-related changes to Lipid Regulation (11.25) -------------------------------------------------------------- To find the...2022-01-2517 min
AMiNDR: A Month in Neurodegenerative Disease Research249 - Cognitive & Behavioural Changes in Alzheimer's Disease: November 2021To kick off the November 2021 series, Ellen brings you 11 papers published this past November on the topic of Alzheimer's disease and dementia. Tune in to hear about research on chronic stress, sleep quality, and an active compound from the cannabis plant that could be used to treat AD symptoms! That's just a taste of what you'll hear about in this episode that covers a diverse array of research all about cognition and behavioural symptoms in AD. Sections in this episode: Mild Behavioural Impairment (3:31) Perception (5:35) Stress & Psychiatric Disturbances (7:28) Sleep (15:47) Pote...2022-01-2127 min
AMiNDR: A Month in Neurodegenerative Disease Research247 - Risk Factors for Alzheimer's Disease Part 2: October 2021Naila is back for part 2, to take you through epidemiological studies on lifestyle factors and comorbidities related to Alzheimer's disease. In today's episode, you'll learn about dietary factors, the association between hair loss and AD, and even a little about Covid-19 (sorry!). Lots to learn in just 13 papers! Sections in this episode: Lifestyle factors (1:39) Nutrition (7:08) Physical and Psychiatric Comorbities (13:30) -------------------------------------------------------------- You can find the numbered bibliography for this episode by clicking here, or the link below: https://drive.google.com/file/d/1PTf3HweI53JJNntYHZlSRjfcJFuOcLJW/view?us...2022-01-1427 min
AMiNDR: A Month in Neurodegenerative Disease Research246 - Risk Factors for Alzheimer's Disease Part 1: October 2021In Part 1 of our episode on epidemiological studies from October 2021, Naila will cover 11 papers on demographic and socioeconomic factors related to dementia and Alzheimer's disease. You'll hear a lot on subjective cognitive decline, education and occupation. Enjoy, and be sure to check out Part 2! Sections in this episode: Prevalence and Demographics (1:33) Education (7:51) Socioeconomic status and occupation (14:13) Other (23:38) -------------------------------------------------------------- You can find the numbered bibliography for this episode by clicking here, or the link below: https://drive.google.com/file/d/1PTf3HweI53JJNntYHZlSRjfcJFuOcLJW/view?usp...2022-01-1226 min
AMiNDR: A Month in Neurodegenerative Disease Research245 - Synaptic Transmission in Alzheimer's Disease: October 2021Thinking about thinking? Changes to synaptic transmission contribute to Alzheimer's disease pathology. Hear all about 10 papers published in October of 2021 exploring synaptic dysfunction in AD from Anusha who hosts this episode. Sections in this episode: Synaptic dysfunction in rodent AD models (2.58) Synaptic dysfunction in other AD models & human studies (16.41) -------------------------------------------------------------- You can find the numbered bibliography for this episode by clicking here, or the link below: https://drive.google.com/file/d/1LYhcoVeGPq5QEWzCqqDCvJsOgMdo3jKt/view?usp=sharingTo access the folder with all the biblio...2022-01-1023 min
AMiNDR: A Month in Neurodegenerative Disease Research243 - Autophagy & Proteostasis in Alzheimer's Disease: October 2021New year, new papers! Join Kate for your monthly update on all things proteostasis and autophagy as they relate to both AD pathology and potential new therapeutic interventions. In today's papers, we'll journey through the endolysosomal system, say "Hi" to some new chaperone families, and even discuss the interplay between AD and other distinct neurodegenerative diseases. Enjoy! Sections in this episode: Autophagy & Proteostasis Pathology (4:42) Targeting Proteostasis/Autophagy Machinery (28:48) -------------------------------------------------------------- You can find the numbered bibliography for this episode by clicking here, or the link below: https://drive.google...2022-01-0634 min
AMiNDR: A Month in Neurodegenerative Disease Research242 - New Variants & Genetic Insights Part 2: October 2021Welcome to our first episode of 2022! Marcia will bring you 13 genetics papers from October 2021. We will talk about all kinds of topics - right from AD-associated loci to polygenetic risk stratification, all of which can contribute to planning effective treatment strategies. Tune in! Sections in this episode: Transcriptomics/Gene Expression Changes (2:33) Genetic Variants (6:16) Genetic Risk (13:14) MicroRNA (20:10) Other Topics (22:52) -------------------------------------------------------------- You can find the numbered bibliography for this episode by clicking here, or the link below: https://drive.google.com/file/d/1ZmtkgGyhe...2022-01-0427 min
AMiNDR: A Month in Neurodegenerative Disease Research241 - New Variants & Genetic Insights Part 1: October 2021Join Marcia for Part 1 of this genetics episode covering a total of 13 papers. In this one, she talks about papers from October 2021, related to transcriptomics, especially genes that are differentially expressed In Alzheimer’s disease, and some studies with vertebrate and invertebrate AD model organisms and risk loci. Tune in to learn more! Sections in this episode: Transcriptomics/Gene expression changes (2:45)Model organisms (17:21) Risk alleles/variants (22:16) Methods (27:09) -------------------------------------------------------------- You can find the numbered bibliography for this episode by clicking here, or the link below:https...2021-12-2430 min
AMiNDR: A Month in Neurodegenerative Disease Research240 - Treatments Targeting Neuroprotection and Neurotransmission: October 2021Hello there! Just in time for the holiday season we've got quite the deal lined up for you. Two episodes for the length of one! Anusha will be guiding you through the literature of October 2021 that focuses on targeting neuronal function and neurotransmission as an Alzheimer's disease treatment. If you want to find out the progress we've been making as a field towards finding better treatments, this is the episode for you! Sections in this episode: Targeting neuronal and synaptic protection (2.33) Targeting neurotransmission (13.27) -------------------------------------------------------------- You can find the numbered bibli...2021-12-2224 min
AMiNDR: A Month in Neurodegenerative Disease Research238 - Brain Imaging of Structural Changes in Alzheimer's Disease: October 2021We have 14 papers in this episode using structural magnetic resonance imaging (sMRI) in the diagnosis or prognosis of Alzheimer's Disease. Join Christy as she walks you through some deep learning based frameworks and other automated models, as well as new findings with grey matter atrophy. Sections in this episode: Deep Learning (2:38) Automated Algorithms & Models (8:24) Grey Matter (17:20) Others - White matter and the Retina (25:00) -------------------------------------------------------------- You can find the numbered bibliography for this episode by clicking here, or the link below:https://drive.google.com/fil...2021-12-1731 min
AMiNDR: A Month in Neurodegenerative Disease Research237 - Tau Protein Pathology in Alzheimer's Disease: October 2021Kate lets you know what's going on in the world of tau protein research in this episode of AMiNDR! Tune in to hear all about tau seeding, tau pathology, and potential therapeutic interventions for Alzheimer's Disease that target this protein. Enjoy! Sections in this episode: Tau seeding-related pathology (3:40) Targeting tau for therapeutic interventions in AD (14:35) -------------------------------------------------------------- You can find the numbered bibliography for this episode by clicking here, or the link below:https://drive.google.com/file/d/1-KRBJQRI7Z9e0EjmqqlZUPYHv34rkUlU/view?usp=sharingTo...2021-12-1620 min
AMiNDR: A Month in Neurodegenerative Disease Research236 - Detecting Amyloid, Tau & New Markers in the Brain: October 2021To kick off our series on papers published in October 2021, we'll look at 7 papers that rely on Positron Emission Tomography (or PET) imaging to detect amyloid and tau pathology in the brain, within the context of Alzheimer's disease! If you're interested in learning about tau and amyloid based detection, alternative PET tracers in AD research, or combining PET with different imaging modalities, make sure to tune into this episode. Sections in this episode: Amyloid Detection (2:35) Tau Detection (7:40) Amyloid + Tau (10:41) Miscellaneous (12:34) -------------------------------------------------------------- To access the folder with al...2021-12-1315 min
AMiNDR: A Month in Neurodegenerative Disease Research235 - Vascular Contributions to Alzheimer's Disease: September 2021Feeling like we're beating a dead horse with the amyloid cascade hypothesis? Think there's an X-factor to Alzheimer disease that is tied to both the clinical symptoms and the plaques? Could be the vasculature! Elyn is back to take you through the 12 papers published on vascular contributions to Alzheimer disease, and hopefully get you excited about this blossoming line of research and the new treatment avenues that come with it. Sections in this episode:White Matter Hyperintensities Amyloid Transport and Clearance Mechanistic Insights from Rodent Models Treatment Avenues ...2021-12-1129 min
AMiNDR: A Month in Neurodegenerative Disease Research231 - Understanding Cognitive & Behavioural Changes in Alzheimer's Disease: September 2021Ellen tells you about research on topics such as cognitive reserve, reinforcement learning, psychiatric conditions, sleep issues, speech, and more in this jam-packed episode on cognitive and behavioural changes in Alzheimer's Disease. Sections in this episode: General Cognition (3:32) Reinforcement Learning (14:09) Speech and Language (16:33) Visuospatial and Motor Control (25:06) Psychiatric Changes (28:15) Sleep and Circadian Rhythms (35:16) -------------------------------------------------------------- You can find the numbered bibliography for this episode by clicking here, or the link below:https://drive.google.com/file/d/1PjokO3cFgLOjtRyi9yjQlckHRNKMtiEM/view?usp=s...2021-12-0243 min
AMiNDR: A Month in Neurodegenerative Disease Research229 - Risk Factors for Alzheimer's Disease Part 1: September 2021In today's episode, Naila takes you through 10 papers on risk factors associated with Mild Cognitive Impairment, Alzheimer's and dementia. You'll hear a little on lifestyle factors, air and noise pollutants, and hormones. Stay tuned for Part 2! Sections in this episode: Lifestyle & Environmental Factors (2:09) Hormones (15:13) -------------------------------------------------------------- You can find the numbered bibliography for this episode by clicking here, or the link below:https://drive.google.com/file/d/1BUfTeMbAC0HzYcXRieJSQdsoNKS9r2J7/view?usp=sharingTo access the folder with all the bibliographies for 2021 so far, follo...2021-11-2721 min
AMiNDR: A Month in Neurodegenerative Disease Research227 - Autophagy & Proteostasis in Alzheimer's Disease: September 2021Tune into this month's episode on the latest research on autophagy and proteostasis in Alzheimer's Disease. This includes papers on how autophagy and protein homeostasis are dysfunctional in this disease, and potential treatments that target these cellular pathways. Enjoy! Sections in this episode: Proteostatic and autophagic dysregulation (4:33) RNA splicing, binding, and signaling (10:32) Glycans, glycoproteins, and fatty acids (19:29) Amyloid precursor protein (24:16) Targeting Proteostasis/Autophagy Machinery (26:55) -------------------------------------------------------------- You can find the numbered bibliography for this episode by clicking here, or the link below:https...2021-11-2332 min
AMiNDR: A Month in Neurodegenerative Disease Research226 - Treatments Targeting Mitochondria & Metabolism in Alzheimer's Disease: September 2021Let’s take a trip with Vee through the latest literature to the mitochondria and learn about oxidative stress, metabolism and related therapeutics in Alzheimer’s disease pathology. A jam packed session from vitamins to energy homeostasis to metal chelators- this episode has it all! We have 10 publications from September 2021, which will surely “power” your interest. Tune in and get ready to charge up on the exciting research! Sections in this episode: Metabolism (4:26) Mitochondria (11:45) Oxidative Stress (19:47) -------------------------------------------------------------- You can find the numbered bibliography for this episode by clicking here...2021-11-1929 min
AMiNDR: A Month in Neurodegenerative Disease Research225 - Detecting Amyloid, Tau and New Markers in the Brain in Alzheimer's Disease: September 2021Let's take a closer look at 18 papers published in September 2021 that rely on positron emission tomography (or PET) to detect amyloid and tau pathology in the brain, within the context of Alzheimer's disease! If you're interested in learning about tau and amyloid based detection, alternative PET tracers in AD research, or combining PET with different imaging modalities, make sure to tune into this episode. Sections in this episode: Amyloid-based detection (2.35) Tau-based detection (9.35) Amyloid & Tau (21.30) Other targets (24.25) -------------------------------------------------------------- You can find the numbered bibliography for this episode...2021-11-1829 min
AMiNDR: A Month in Neurodegenerative Disease Research224 - Tau Protein Pathology in Alzheimer's Disease: September 2021Tired of untangling the tricky world of tau literature all on your own? Interested in the mechanisms of tau pathology, therapeutic advancements targeting tau, or both? Join Kate for another exciting episode covering 20 new papers published in September 2021. We’ll explore tau aggregation, regulation, and treatment development through a wide variety of model systems, from molecular dynamics all the way to human subjects - so, tune in to learn more! Sections in this episode: New tau pathological findings (3.17) Tau and Neuroinflammation (7.46) Tau Aggregation (10.24) Tau Pathology from Prion-like Seeding Behaviour (13.24) Tre...2021-11-1636 min
AMiNDR: A Month in Neurodegenerative Disease Research223 - Treatments Targeting Neurotransmission in Alzheimer's Disease: September 202118 papers published in September of 2021 await you. What do they all have in common? They explore treatments for Alzheimer's disease that all target neurotransmission. If you're interested in restoring acetylcholine balance or other treatments that also improve cognitive function in Alzheimer's disease, tune in to hear Anusha take you through the literature. Sections in this episode: Discovery and synthesis of novel cholinesterase inhibitors (3.17) Tacrine-based cholinesterase inhibitors (11.26) Modifying existing treatments (16.16) Multi-target treatments (23.00) -------------------------------------------------------------- You can find the numbered bibliography for this episode by clicking here, or the lin...2021-11-1227 min
AMiNDR: A Month in Neurodegenerative Disease Research222 - Changes to Synaptic Transmission in Alzheimer's Disease: September 2021Are you interested in neuronal hyperexcitability, impairments in synaptic plasticity, and interactions between amyloid plaques and synaptic proteins in Alzheimer's disease pathology? You've come to the right podcast! In this episode, Glory will guide you through 11 publications from September 2021 on the latest research about the mechanisms of synaptic transmission and plasticity that contribute to the Alzheimer's disease. Hit that play button to hear all of the exciting new insights on the AD synapse. Sections in this episode: Neurotransmitters systems involved in AD (2:56) Neuronal structure (11:42) Neuron Excitability (14:33) Amyloid beta and APP a...2021-11-1126 min
AMiNDR: A Month in Neurodegenerative Disease Research221 - Treatments Targeting Synaptic & Neuronal Protection in Alzheimer's Disease: September 2021The first episode of our September 2021 series gets us acclimated with papers that target neuronal and synaptic function in preclinical studies of Azheimer's disease. Join Anusha and she walks you through papers that explore topics like rescuing amyloid beta-induced toxicity, restoring neuronal morphology, and using animal models of Alzheimer's disease to target neuronal function. Sections in this episode: Targeting A-Beta-Induced Toxicity (2.21) Restoring Neuronal Morphology and Promoting Neurogenesis (7.26) Restoring Neuronal Function in AD Animal Models (15.40) -------------------------------------------------------------- You can find the numbered bibliography for this episode by clicking here, or the...2021-11-0823 min
AMiNDR: A Month in Neurodegenerative Disease Research218 - Cognitive and Behavioural Changes in Alzheimer's Disease: August 2021In today's episode of AMiNDR, we’ll be talking about the latest work on cognitive and behavioural changes in Alzheimer's Disease, including papers on executive functioning, depression, social impairments, motor coordination, and more. Join Ellen as she guides you through 18 papers on the mechanisms behind cognition and other neuropsychological symptoms in AD! Sections in this episode: Cognitive Profiles (4:07) Executive Functions (13:06) Exercise & Cognition (18:12) Psychiatric & Social Symptoms (21:54) Motor Coordination & Balance (34:09) Sleep & Circadian Rhythms (35:52) -------------------------------------------------------------- You can find the numbered bibliography for this epi...2021-10-3041 min
AMiNDR: A Month in Neurodegenerative Disease Research214 - Risk Factors for Alzheimer's Disease: August 2021Make yourself comfortable, because we cover a lot of ground in today's episode. Naila will guide you through 24 papers from August 2021, all pertaining to epidemiological studies on the risk and protective factors related to AD. You'll hear about some basic epidemiology, environmental and socioeconomic risk factors, lifestyle factors, and health conditions related to AD. Sections in this episode: Epidemiology & Social Factors (1.52) Diet (16.53) Sleep (24.19) Comorbidities (28.00) -------------------------------------------------------------- You can find the numbered bibliography for this episode by clicking here, or the link below:https://drive.google...2021-10-2147 min
AMiNDR: A Month in Neurodegenerative Disease Research212 - Synaptic Transmission in Alzheimer's Disease: August 2021Want to know more about about how the brain's different neurotransmitter systems aren't functioning properly in Alzheimer's disease and how hippocampal synaptic plasticity impairment contributes to Alzheimer's pathology? Join Glory for the latest updates on research about the mechanisms of synaptic transmission and plasticity that contribute to the Alzheimer's disease pathology. With this month's new papers, August 2021 gives us 12 publications that try to answer all of your questions on the synaptic aspects of AD! You're sure to get your own synapses firing by listening to this episode! Sections in this episode: Neurotransmitters and neuropeptides (3:01) E...2021-10-1624 min
AMiNDR: A Month in Neurodegenerative Disease Research211 - Changes to Gene Expression in Alzheimer's Disease: August 2021“Changes to the expression of genes may influence the delicate balance between disease and health”. If you want to learn about how that is relevant to Alzheimer’s disease, you’ve come to the right place! Join Marcia for this short episode, as she discusses how & why gene expression, its epigenetic regulation and integrative studies are important in Alzheimer’s disease! Sections in this episode: Transcriptome (2:35) Multiomics (8:19) Epigenetics (12:03) -------------------------------------------------------------- You can find the numbered bibliography for this episode by clicking here, or the link below:http...2021-10-1417 min
AMiNDR: A Month in Neurodegenerative Disease Research209 - Treatments targeting Neurotransmission in Alzheimer's Disease: August 2021This is an episode that explores the creation and testing of drugs that aim to restore neurotransmitter balance in Alzheimer's disease. It covers 14 papers that were all published in August of 2021, and Anusha will guide you through papers on targets including cholinesterases, serotonin, and glutamate receptors. Hit that play button if you'd like to hear more. Sections in this episode: Targeting acetylcholine with novel compounds (2.29) Other targets with novel compounds (13.23) Testing for or improving upon existing ACE inhibitors (17.28) -------------------------------------------------------------- You can find the numbered bibliog...2021-10-0924 min
AMiNDR: A Month in Neurodegenerative Disease Research207 - Treatments targeting neuroprotection & synaptic activity in Alzheimer's Disease: August 2021Another month passed means another month of literature for AMiNDR to bring to you! This time, Anusha will be highlighting papers from August of 2021 that are about treatments targeting neuroprotection and synaptic activity in Alzheimer's disease. Beginning with computation and cuvettes and ending with clinical trials, we have 15 papers for your perusal so check out this episode if this topic tickles your fancy. Sections in this episode: Drug discovery and testing in vitro (2.26) Testing potential compounds in AD models (7.06) Phase II Clinical Trials (21.42) -------------------------------------------------------------- You can...2021-10-0526 min
AMiNDR: A Month in Neurodegenerative Disease Research205 - Treatments targeting neurotransmission in Alzheimer's Disease: July 2021Journey through the entire spectrum of drug development as Anusha guides you through 19 papers that were published in July of 2021. We span research that begins with drug discovery all the way to the end goal: Phase II clinical trials. If you're interested in targeting levels of acetylcholine and monoamines, you're really going to like this episode! Sections in this episode: Synthesis and Discovery of Cholinesterase Inhibitors (2.47) Drug Interactions with Multiple targets (9.29) Pre-clinical Trials (18.23) Clinical Trials (25.39) -------------------------------------------------------------- You can find the numbered bibliography for this...2021-09-2230 min
AMiNDR: A Month in Neurodegenerative Disease Research204 - Clinical Markers of Alzheimer's Disease Part 2: July 2021In this episode, Ellen tells you about 9 papers that have developed new ways to screen for dementia. Some of these are old, tried-and-true cognitive screening tools that are given a new twist, others are brand new technology that bring cognitive testing to the modern age. You’re sure to find something you enjoy in this episode if you do neurodegenerative disease research, or even if you don’t! Sections in this episode: Technology-based tools (3:44) Adapting tests to other languages (8:34) Other new tools for testing cognition (12:22) -------------------------------------------------------------- You ca...2021-09-2121 min
AMiNDR: A Month in Neurodegenerative Disease Research203 - Clinical Markers of Alzheimer's Disease Part 1: July 2021In the first part of this 2-parter episode, Ellen covers studies that compare and contrast different cognitive tests, or analysis techniques, for diagnosing AD at early stages, or predicting the conversion of pre-dementia stages to Alzheimer’s Disease. There are also some studies that compare cognitive abilities between different types of dementia. You'll hear about memory, spatial awareness, social cognition, and more! Sections in this episode: Cognitive decline & memory (3:32) Semantic fluency (16:42) Social cognition (18:21) Spatial awareness (21:47) -------------------------------------------------------------- You can find the numbered bibliography for this e...2021-09-1725 min
AMiNDR: A Month in Neurodegenerative Disease Research200 - Connectivity Changes in Alzheimer's Disease: July 2021In this shorter episode, Judy covers studies on structural and functional connectivity changes in AD, as well as new methods of integrating multimodal neuroimaging data. All 9 papers were published in July 2021 and focus on improving AD diagnosis using deep learning, specific fMRI measures and more - be sure to check it out! Sections in this episode: fMRI (2:11) Default Mode Network (8:16) Other (10:10) -------------------------------------------------------------- You can find the numbered bibliography for this episode by clicking here, or the link below:https://drive.google.com/file/d...2021-09-1416 min
AMiNDR: A Month in Neurodegenerative Disease Research199 - Treatments targeting neuroprotection in Alzheimer's Disease: July 2021Animal and cell models of Alzheimer's Disease are featured in this episode that covers potential therapeutics that target neuroprotection. We have 5 papers that focus broadly on the subject and 10 more that delve into mechanisms of action of these compounds so join Anusha as she highlights July of 2021's publications on the topic! Sections in this episode: Treatments targeting neuroprotection (1.03) Mechanism of treatments targeting neuroprotection (11.14) -------------------------------------------------------------- You can find the numbered bibliography for this episode by clicking here, or the link below:https://drive.g...2021-09-1026 min
AMiNDR: A Month in Neurodegenerative Disease Research198 - Understanding Cognitive & Behavioural Changes in Alzheimer's Disease: July 2021Visual reaction time, japanese orange scent, language, psychosis, and insomnia are just some of the topics you’ll hear about today in this episode. Have we piqued your interest? Today Ellen tells you about the latest papers on the mechanisms of, and treatments for, cognitive and behavioural changes in Alzheimer's Disease. Enjoy the show! Sections in this episode: Sensory processing & function (3:31) Speech (9:16) Learning & memory (11:17) Psychiatric changes (13:50) Sleep (21:20) -------------------------------------------------------------- You can find the numbered bibliography for this episode by clicking here, or the link below:...2021-09-1031 min
AMiNDR: A Month in Neurodegenerative Disease Research196 - Changes to Gene Expression in Alzheimer's Disease: July 2021“Omics”, “differential expression” and “biomarker discovery” – Are these phrases you commonly use in your research? Or have you come across them and wondered what they meant in the context of AD? If you're nodding your head at either of those, this episode is just for you. Join Marcia as she brings you the latest research published in July 2021 on ‘RNA, Transcription and translation in AD’! Sections in this episode: Gene expression and transcriptomics (02:26) Proteomics (17:38) -------------------------------------------------------------- You can find the numbered bibliography for this episode by clicking here, or the link below...2021-09-0725 min
AMiNDR: A Month in Neurodegenerative Disease Research195 - Metabolic Changes, Hemodynamics and EEG studies in Alzheimer's Disease: July 2021Curious about oxidative stress, default mode network markers and EEG patterns associated with Alzheimer's disease? Join us for an exciting episode on metabolic changes, hemodynamics and EEG featuring papers published in July 2021! Studies include conventional and newer methods of improving AD diagnosis, such as recording electrical activity from the outer ear using electrovestibulography or tracking brain metabolite changes in real time with functional magnetic resonance spectroscopy. Come hear about the latest research! Sections in this episode: Metabolic Changes (2:08) Hemodynamics (13:05) EEG (17:34) -------------------------------------------------------------- You can find the numbered bibliography for th...2021-09-0722 min
AMiNDR: A Month in Neurodegenerative Disease Research194 - Treatments targeting Neurotransmitter Imbalances: June 2021In this episode, Anusha will guide you through 20 papers that tackle acetylcholine and glutamate imbalances in Alzheimer's Disease. These papers were published in June of 2021 and address topics like inhibiting cholinesterases and NMDA receptors. We hope this information transmits to your neurons! Sections in this episode: Novel Anti-Cholinesterase Drugs (2.39) Existing Anti-Cholinesterase Drugs (16.28) Targeting Glutamate (26.17) -------------------------------------------------------------- To access the folder with all the bibliographies for 2021 so far, follow this link (it will be updated as we publish episodes and process bibliographies), or click the following link below:http...2021-08-1930 min
AMiNDR: A Month in Neurodegenerative Disease Research193 - Clinical Markers of Alzheimer's Disease: June 2021In this episode, Maria will be going over 17 papers published in June 2021 on Clinical Indicators of Alzheimer's diseaes and mild cognitive impairment. Topics covered will include the use of technology to assess cognition, semantic memory, cognitive tests, behavioural tests, oculomotor tests, and language adaptations. If you're interested in new ways of detecting AD, make sure you tune in! Sections in this episode:Technology for AD and MCI (2:08) Semantic Memory(8:11) Test for Aspects of Cognition (11:38) Oculomotor Markers of Cognition (20:50) Language Adaptations (23:03)-------------------------------------------------------------- Click...2021-08-1829 min
AMiNDR: A Month in Neurodegenerative Disease Research192 - Risk Factors for Alzheimer's Disease: June 2021Naila has 23 papers for you today, that will provide you with an overview of epidemiological research published in June 2021. You'll hear about the incidence and prevalence of AD in specific populations, sociodemographic and health conditions that increase the risk of dementia and AD, and about a few potentially neuroprotective factors as well. Enjoy! Sections in this episode: Prevalence, incidence, multiple factors (2:08) Cardiovascular (20:33) Other health conditions (25:30) Protective (40:52) -------------------------------------------------------------- To access the folder with all the bibliographies for 2021 so far, follow this link (it will be updat...2021-08-1748 min
AMiNDR: A Month in Neurodegenerative Disease Research189 - Vascular Contributions to Alzheimer's Disease & Treatments Targeting the Vasculature: June 2021With a shorter epsiode than usual this month, Elyn is back with an update on vascular contributions to Alzheimer disease and potential treatment avenues targeting the vasculature. Tune in for a summary of 8 papers spanning clinical studies that unpack neuroimaging hallmarks of vascular changes in AD, all the way to mechanistic studies focused on understanding blood-brain barrier dysfunction in Alzheimer disease, and a bonus inclusion of a fluid biomarkers paper on the plasma lipidome! Sections in this episode: Clinical Studies – Neuroimaging and Cardiovascular Risk (4:20) Mechanistic Studies – BBB dysfunction and rescue (13:20) Bonus paper on...2021-08-1221 min
AMiNDR: A Month in Neurodegenerative Disease Research186 - Treatments targeting neuronal protection in Alzheimer's Disease: June 2021Join our host Anusha as she takes you through papers published in June of 2021 that target neuroprotection as a potential treatment avenue for Alzheimer's disease. Half these papers use amyloid-beta induced models of Alzheimer's disease so be sure to check it out if neuroprotection is up your alley. Sections in this episode: Treatments targeting neuroprotection in amyloid-beta induced AD models (2.03) Neuroprotection in other AD models (12.51) -------------------------------------------------------------- You can find the numbered bibliography for this episode by clicking here, or the link below:https://drive.google.com/file/d...2021-08-0724 min
AMiNDR: A Month in Neurodegenerative Disease Research185 - Metabolic Changes, Hemodynamics and EEG in Alzheimer's Disease: June 2021In this shorter episode, Judy goes over papers published in June 2021 that focus on diagnostic tools of Alzheimer's disease. Topics include metabolic changes, hemodynamics and EEG biomarkers. Listen in to find out more! Sections in this episode: Metabolic changes in AD (1:20) Hemodynamics (9:30) EEG (13:30) -------------------------------------------------------------- You can find the numbered bibliography for this episode by clicking here, or the link below:https://drive.google.com/file/d/1lzkStThvq02V_tpeuqBDfmZuLlhg6RwQ/view?usp=sharingTo access the folder with all the bibliog...2021-08-0618 min
AMiNDR: A Month in Neurodegenerative Disease Research184 - Synaptic Transmission in Alzheimer's Disease: June 2021Curious about how neuronal hyperactivity and hippocampal synaptic plasticity impairment contribute to Alzheimer's pathology? Join Glory for the latest updates on research about the mechanisms of synaptic transmission and plasticity affected in Alzheimer's disease. This month, June 2021, delivers 17 new papers that will fill you in on all things synaptic in AD! Give it a listen to find out more and stimulate your own synapses! Sections in this episode: Synapse Function and Plasticity (2:17) Neurotransmitter Systems Affected in AD (11:04) Neuronal Hyperactivity and Calcium Signaling (18:45) Spatial Memory (24:30) Animal Models...2021-08-0533 min
AMiNDR: A Month in Neurodegenerative Disease Research182 - Cognitive & Behavioural Changes in Alzheimer's Disease: June 2021Ellen kicks off this series by telling you about the latest research from June 2021 on topics like cognition, memory, reading, gait, speech, depression, sleep, and even more. Learn how these symptoms may manifest in Alzheimer's disease patients, and the underlying mechanisms that contribute to them. If you're interested in behaviour and cognition in humans or in animals, this episode is for you! Sections in this episode: Cognition & Attention (3:32) Memory (9:59) Speech & Communication (16:31) Gait (23:05) Psychiatric Symptoms (26:58) Sleep & Circadian Rhythms (30:32) -------------------------------------------------------------- You can find the numbe...2021-08-0339 min
AMiNDR: A Month in Neurodegenerative Disease Research180 - Clinical Markers of Alzheimer's Disease Part 1: May 2021In this episode, Maria goes over 22 papers from May 2021 on various cognitive tests for Alzheimer's disease and mild cognitive impairment. Paper topics include tests of general cognition, visual, verbal and auditory tests, dementia subtypes, machine learning, and language and culturally adapted tests. Sections in this episode: General cognition (2:00) Visual, verbal, and auditory testing (13:50) Other dementia subtypes (18:43) Machine learning (25.08)Language and cultural adaptations (29.32)-------------------------------------------------------------- To access the folder with all the bibliographies for 2021 so far, follow this link (it will be updated as we p...2021-07-1433 min
AMiNDR: A Month in Neurodegenerative Disease Research179 - Treatments targeting the Immune System & Glial Cells in Alzheimer's Disease: May 2021Abdullah takes you through papers from May 2021 on treatments to target the immune system and glial cells to treat Alzheimer's Disease. This includes things like coconut looking funguses and olive oil. These are just a few of the treatments being covered in this episode, tune in to find out more! Sections in this episode: Inflammasomes (3:31) Effects on Neuroinflammation (9:17) Miscellaneous Papers (24:20) -------------------------------------------------------------- To access the folder with all the bibliographies for 2021 so far, follow this link (it will be updated as we publish episodes and process...2021-07-1335 min
AMiNDR: A Month in Neurodegenerative Disease Research178 - Amyloid-Beta Pathology in Alzheimer's Disease: May 2021In the second part of our episodes on amyloid-beta, we focus on the ways abeta contributes to AD pathology. This ranges from its effects on the hippocampus and memory, to more mechanistic studies on ion homeostasis, lipid membrane integrity, and prion-like seeding, without forgetting our friend tau! Tune in for an episode as eventful as an episode of Game of Thrones where amyloid-beta wages a war on the good people of Westeros…or...wages a war on neurons. Enjoy! Sections in this episode: Amyloid-beta toxicity: (9:05) Iron Dyshomeostasis: (18:13) Prion-Like Seeding & Spread: (24:19) Miscel...2021-07-1038 min
AMiNDR: A Month in Neurodegenerative Disease Research177 - Treatments targeting Neurotransmitter Balance in Alzheimer's Disease: May 2021This episode of AMiNDR highlights literature published in May of 2021 that target neurotransmitter balance in Alzheimer's Disease. Greatest hits include cholinesterase inhibition, targeting glutamate excitotoxicity, and there's even a bonus paper on adrenergic transmission. Get excited! But maintain homeostasis. Sections in this episode: Targeting cholinesterases and oxidative stress (1.56) Targeting glutamate and excitotoxicity (22.33) Targeting Adrenergic Receptor (26.58) -------------------------------------------------------------- To access the folder with all the bibliographies for 2021 so far, follow this link (it will be updated as we publish episodes and process bibliographies), or click the following link be...2021-07-0930 min
AMiNDR: A Month in Neurodegenerative Disease Research174 - Understanding Cognitive & Behavioural Changes in Alzheimer's Disease Part 2: May 2021In part 2 of this set of episodes, Ellen dives into papers on psychiatric changes and sleep disturbances in the context of AD. This includes research looking at depression, anxiety, agitation, circadian rhythm, and more in AD patients, animal models, and even clinical trials! There's sure to be something for everyone in this diverse set of papers, enjoy! Sections in this episode: Depression (2:27) Anxiety (5:26) Stress & PTSD (9:55) Agitation (13:30) Emotional Reactivity (17:13) Sleep & Circadian Rhythms (19:12) -------------------------------------------------------------- You can find the numbered bibliography for this episode by clicking...2021-07-0633 min
AMiNDR: A Month in Neurodegenerative Disease Research171 - Understanding Cognitive & Behavioural Changes in Alzheimer's Disease Part 1: May 2021In part one of this 2-parter, Ellen will tell you all about the latest studies on cognition and motor deficits in AD. This includes mechanistic studies, as well as studies looking at potential treatment avenues for these symptoms. We hope you enjoy, and stay tuned for part 2 coming out soon! Sections in this episode: Cognition in AD patients (4:09) Cognition in animal models (9:38) Motor impairments (19:00) ------------------------------------------------------------- PLEASE FILL OUR SURVEY TO HELP US IMPROVE OUR PODCAST, AND ENTER A DRAW FOR A $30 GIFT CARD. Link if you prefer...2021-07-0124 min
AMiNDR: A Month in Neurodegenerative Disease Research169 - Treatments targeting Neuroprotection and Synaptic Activity in Alzheimer's Disease: May 2021Anusha will guide you through 21 papers in this episode that target synaptic and neuroprotection as therapeutic intervention for Alzheimer's disease. She covers 3 topics including the use of pre-existing synthetic compounds, naturally occuring compounds, and designing and optimizing drugs to improve efficacy. All of these papers were published in May of 2021 so be sure to check it out to offer your neurons protection from ignorance! Sections in this episode: Using Pre-existing Synthetic Compounds (2.21) Using Naturally Occurring Compounds (12.36) Drug Design (26.35) ------------------------------------------------------------- PLEASE FILL OUR SURVEY TO HELP US IMPROVE OUR PODC...2021-06-2935 min
AMiNDR: A Month in Neurodegenerative Disease Research168 - Prevention and Intervention Strategies for Alzheimer's Disease: May 2021In this episode, Naila tackles 21 papers on diet, exercise, complementary therapies, cognitive training, and neurostimulation techniques. There's lots on the potential cellular mechanisms of exercise, several studies using Alzheimer's disease biomarkers as outcome measures, and even a paper on dog-assisted therapy! Hope you enjoy May's smattering of papers on pevention and intervention strategies for AD. Sections in this episode:Diet (2:52)Exercise (9:01)Multidomain Interventions (26.21)Cognitive training (34:29)Neuromodulatory techniques (37:30) ------------------------------------------------------------- PLEASE FILL OUR SURVEY TO HELP US IMPROVE OUR PODCAST, AND ENTER...2021-06-2646 min
AMiNDR: A Month in Neurodegenerative Disease Research164 - Synaptic Transmission in Alzheimer's Disease: May 2021Ellen kicks off the May 2021 series with 20 papers all about synaptic transmission in Alzheimer's Disease. This includes topics like synaptic plasticity, neurotransmitters like acetylcholine, dopamine, and serotonin and how they're involved in AD, growth factors, morphological changes, and much more! Enjoy the show! Sections in this episode:Neurogenesis (5:11)Synaptic Plasticity (8:46)Neurotransmitter Signaling (18:26)Excitation/Inhibition Balance (28.07)Growth Factors (32:16)Morphological & Anatomical Changes (35:46)-------------------------------------------------------------- PLEASE FILL OUR SURVEY TO HELP US IMPROVE OUR PODCAST, AND ENTER A DRAW FOR A $30 GIFT CARD. ...2021-06-2245 min
AMiNDR: A Month in Neurodegenerative Disease Research147 - Treatments targeting neuroprotection, synaptic activity & neurotransmitter release in Alzheimer's Disease: March 2021Anusha will be summarizing for you papers published in March of 2021 that address neuronal and synaptic health in models of Alzheimer’s disease. That’s not all! We are also going to explore the topic of restoring neurotransmitter balance. So if for instance, you’re looking for research on acetylcholinesterase inhibition, this episode is for you! Sections in this episode: Targeting neuro/synaptic protection with peptides (2.29) Using existing drugs (9.42) Disease mechanisms (17.26) Targeting acetylcholine (21.03) Targeting GABA (26.10) Drug discovery (27.57) Drug development (33.02) -------------------------------------------------------------- To access th...2021-05-1143 min
AMiNDR: A Month in Neurodegenerative Disease Research132 - Changes to synaptic function and plasticity in Alzheimer's Disease: February 2021Want to learn more about how changes in synaptic function, structure and plasticity are implicated in neurodegenerative disease pathology? We've got you covered with this episode! Glory will guide you through 18 papers from February 2021 that explore mechanisms which underlie the synaptic dysfunction that can lead to Alzheimer's disease, ranging from the molecular level to the more global level of brain-wide connectivity. Sections in this episode: Synaptic and Axonal Function (1:59) Brain Connectivity and Neuronal Networks (4:07) Metabolites and Neurotransmitters (7:20) Synaptic Plasticity (14:29) Brain Injury (22:33) --------------------------------------------------------------To acc...2021-04-0625 min
AMiNDR: A Month in Neurodegenerative Disease Research128 - Treatments targeting Neuroprotection, Synaptic Activity, and Neurotransmitter Balance in Alzheimer's Disease: February 2021To kick of the February 2021 series, Anusha guides you through papers recently published that target synaptic health and acetylcholinesterase activity to uncover pathological mechanisms that underlie Alzheimer's disease. If you like thinking about thinking, look no further than this episode! Sections in this episode: Synaptic Plasticity and Preservation (2:05) Oxidative Stress (8:52) Miscellaneous (12:37) Acetylcholinesterase Inhibitor Rivastigmine (17:47) Novel Inhibitors (21:36) --------------------------------------------------------------You can find the bibliography for this episode by clicking here! To access the folder with the bibliographies for the month of Ja...2021-04-0133 min
AMiNDR: A Month in Neurodegenerative Disease ResearchCognitive Changes & Synaptic Transmission: Alzheimer's Disease June 2020Having trouble keeping up with the literature in Alzheimer's Disease? We are here to help! In this episode, we cover the papers published in June 2020 about cognitive changes and synaptic transmission in Alzheimer's disease. You get 2 for 1! To receive the list of papers covered (with time-stamps), please subscribe to our mailing list. You can do so by filling this form: --------> https://forms.gle/CVVbznAFM8pamdgk6 -------or by sending us an email at ---------> amindrpodcast@gmail.com-----------------------------------------------------------------------List of sections in this episode: Cognitive...2020-07-2923 min