Shows
AMiNDR: A Month in Neurodegenerative Disease Research341 - Prevention & Intervention Strategies for ADNaila brings you 21 articles from January 2024, on non-pharmacological approaches to the prevention and intervention of Alzheimer's disease. You'll be treated to research from computational modeling, to rodent models, to clinical trials, with a particular focus on optimizing and personalizing intervention strategies. This episode also covers some research on the role of caregivers, and several papers consider the socioeconomic and ethnographic context in which these studies take place. Let's get to it! Stimulation Techniques (7)Exercise (3)Cognitive Training (2) Art Therapy and Dyad Interventions (4)Lifestyle Interventions and Prevention (5)...2024-04-0946 min
AMiNDR: A Month in Neurodegenerative Disease Research340 - Structure Neuroimaging in Alzheimer's Disease using AIJoin Christy for 12 papers from January 2024 on structural neuroimaging in the diagnosis of Alzheimer's disease. This episode is a bit different from past ones because it's all about the use of machine learning and deep learning. Whether you're an AI researcher or simply curious about the topic, you won't want to miss this episode. Detecting AD (3:42) Predictions, associations or comparisons (16:48)-------------------------------------------------------------- You can find the bibliography for this episode here, or by clicking the link below:https://drive.google.com/file/d/1KE4oVzsdER5iTuSqN9J5UMUk27S5w...2024-04-0231 min
AMiNDR: A Month in Neurodegenerative Disease Research339 - Treatments Targeting Neuroprotection in Alzheimer's DiseaseAnother series of AMiNDR kicks off with this episode. Anusha takes you through 7 papers published in January 2024 targeting neuroprotection in AD. If you'd like to hear about potential compounds that could reduce neurodegeneration in Alzheimer's disease, this is the episode for you.Testing for neuroprotection in cell lines (2:57)Testing for neuroprotection using in vivo AD models (11:47)-------------------------------------------------------------- You can find the bibliography for this episode here, or by clicking the link below:https://drive.google.com/file/d/1A4HZVCtgh5AwZkd5V2ATZSFAxGJt48q3/view?usp=drive_linkT...2024-03-2619 min
AMiNDR: A Month in Neurodegenerative Disease Research338 - Interview with Joseph Liang - Navigating The Journey To (And Through) Graduate SchoolAnother special episode to help kick off our return! In what we hope to be a recurring special series, an interview with members in our scholarly community on navigating the multiple facets of life as a scientist. In the first episode, host Kevin Nishimura interviews one of our own Joseph Liang on his personal journey to and through graduate school. Tune in to learn what he has to say about getting into graduate school, and how his perspective on the journey has changed since he's started! We hope you enjoy, and please let us know if you want to...2024-02-2024 min
AMiNDR: A Month in Neurodegenerative Disease Research337 - Prevention & Intervention Strategies for ADIn today's episode, Naila provides an overview of 14 articles published in November 2023 on non-pharmacological interventions for AD. You'll hear about cognitive training, music therapy, chair yoga, providing support to caregivers, and a range of neural stimulation techniques. Enjoy! Cognitive and Social Factors (2:26)Lifestyle interventions (13:40)Stimulation Techniques (19:20)-------------------------------------------------------------- You can find the bibliography for this episode here, or by clicking the link below:https://drive.google.com/file/d/1A4HZVCtgh5AwZkd5V2ATZSFAxGJt48q3/view?usp=drive_linkTo access the folder with AL...2024-02-1429 min
AMiNDR: A Month in Neurodegenerative Disease Research336 - Treatments Targeting Cholinergic Neurotransmission in ADJoin us as we cover a set of papers published in November 2023 on treatments targeting cholinergic transmission in Alzheimer's disease. In this episode hosted by Christy, we will go over various topics, from drug discovery using synthesized compounds to drug testing of plant extracts, as well as improving drug delivery through the blood-brain barrier. Enjoy! Papers evaluating synthesized compounds (2:00) Papers targeting AchE (10:45)-------------------------------------------------------------- You can find the bibliography for this episode here, or by clicking the link below:https://drive.google.com/file/d/1wh1EFtB3KrW0J6C...2024-02-0629 min
AMiNDR: A Month in Neurodegenerative Disease Research335 - A Conversation with Gina Martin: Bringing Visual Awareness to DementiaAs we get back up to speed on our regular episodes, we thought we'd treat you (and ourselves) to something out of the ordinary: a conversation on how visual storytelling can shape how we think - and feel - about Alzheimer's disease. Host Naila Kuhlmann had the pleasure of interviewing Gina Martin, who founded the Bob and Diane Fund to support and promote visual storytelling about Alzheimer's and dementia. Tune in to get the backstory on the fund, an auditory glimpse at the work of this year's winner, a discussion on the social narrative of Alzheimer's disease, and reflections...2024-01-2952 min
AMiNDR: A Month in Neurodegenerative Disease Research333 - Cognitive & Behavioural Changes in Alzheimer's Disease: February 2023If you’re interested in hearing about the impact of hearing aids on quality of life in AD patients, or how having a stable life partner can slow down the progression of dementia, tune in to this episode on the latest in cognitive and behavioural research in Alzheimer's disease! Judy will cover 9 papers on sleep, depressive symptoms and sensory processing, all published in February 2023. This is one you don't want to miss! Sections in this episode: Sleep (2:42) Depressive Symptoms (8:05) Sensory Processing (12:59) -------------------------------------------------------------- You can find the bibliography for this...2023-05-0819 min
AMiNDR: A Month in Neurodegenerative Disease Research332 - Prevention & Intervention Strategies for Alzheimer's Disease: February 2023In today's episode, Naila provides you with an overview of 10 paper published in February 2023, on non-pharmacological therapies for Alzheimer's disease. You'll learn about a virtual reality intervention targeting anxiety, the signaling pathways underlying the potential benefits of acupuncture, the challenges of implementing new interventions, and what spectral light flicker means. Happy listening! Sections in this episode: Psychological Interventions (1:37) Physical Activity (7:26) Neuromodulatory Techniques (14:05) -------------------------------------------------------------- You can find the bibliography for this episode here, or by clicking the link below:https://drive.google.com/file/d/1ZG-uORwCnfP383EN7-a2...2023-05-0327 min
AMiNDR: A Month in Neurodegenerative Disease Research331 - Treatments Targeting Neuroprotection in Alzheimer's Disease: February 2023This short and sweet episode kicks off the February 2023 series, highlighting studies all the way from worms to humans. Anusha will take you through 9 papers that converge on targeting neuroprotection in Alzheimer's disease. If you're interested in learning about implicated pathways or potential therapeutics, this episode is sure to whet your appetite. Sections in this episode: Targeting Specific Neuroprotective Pathways (3:39) Targeting Neuroprotection Broadly (13.21) -------------------------------------------------------------- You can find the bibliography for this episode here, or by clicking the link below:https://drive.google.com/file/d/1n7wQss1hiT-F...2023-05-0223 min
AMiNDR: A Month in Neurodegenerative Disease Research323 - The Immune System & Glia in Alzheimer's Disease Part 1: November 2022Welcome our new host, Anelya, who covers 12 papers on the role of immune system and glia in Alzheimer’s disease. The first half of this episode will focus on potential targets for the treatment of Alzheimer’s disease, followed by the disease-associated inflammatory mechanisms. Part 2 will be released as a bibliography. We hope you find this episode interesting! Sections in this episode: Potential Therapeutic Agents (2:28) Disease-Associated Neuroinflammatory Mechanisms (14:08) -------------------------------------------------------------- To find the numbered bibliography with all the papers covered in this episode, click here, or use the link below:http...2023-03-0927 min
AMiNDR: A Month in Neurodegenerative Disease Research314 - Vascular Changes in Alzheimer's Disease: October 2022In this episode, Elyn takes you through 13 papers from October 2022 published on vascular contributions to Alzheimer disease. It's quite the journey through mechanistic mouse studies, neuroimaging studies, and a few studies assessing treatments targeting the vasculature, which all paint a pretty convincing picture of the importance of the cerebrovasculature in brain health. Tune in to learn more about the glymphatic system, consequences of amyloid deposition on the vasculature, and a clinical study testing out albumin replacement as an AD treatment! Sections in this episode: Vascular Implications of Amyloid Accumulation (3:52) Glymphatic System (7:31) ...2023-01-1730 min
AMiNDR: A Month in Neurodegenerative Disease Research311 - Understanding APOE: August 2022In this month's episode of AMiNDR, Cassi recaps papers on APOE published in August 2022. Cassi just defended her dissertation where she studied immunometabolism in the context of APOE. She starts with cells, moves to mice, and finishes with human research studies. -------------------------------------------------------------- To find the numbered bibliography with all the papers covered in this episode, click here, or use the link below:https://drive.google.com/file/d/11pGVGJGUWfPNAqJ-Jw7cUGyUGb_HRXwy/view?usp=drivesdkTo access the folder with ALL our bibliographies, follow this link (it will be updated as we pu...2022-12-2228 min
AMiNDR: A Month in Neurodegenerative Disease Research309 - Vascular Changes in Alzheimer's Disease: August 2022After a bit of a break, Elyn is excited to be back with the latest in the field of vascular contributions to Alzheimer disease. With the current (and constant) controversy in the field about targeting amyloid as a disease-modifying therapy, perhaps it's time we turned to a new target: the vasculature. Tune in for an overview of papers published in August 2022, including lots of nitric oxide signalling, animal model characterization, white matter hyperintensities and their relevant associations, and much more! Sections in this episode: Vascular Remodeling and Nitric Oxide Signaling (3:36) White Matter Hyperintensities and...2022-12-1327 min
AMiNDR: A Month in Neurodegenerative Disease Research302 - Vascular Changes in Alzheimer's Disease: July 2022Elyn is back to discuss the latest research on vascular contributions to Alzheimer disease! Tune in to hear about proteomic changes with amyloid deposition in the vasculature, new therapeutic avenues, and a more detailed account of the perivascular space. If you're interested in factors beyond amyloid and tau in the Alzheimer disease pathology, this is a great place to start! Sections in this episode: Cardiovascular Risk Factors (3:45) White Matter Hyperintensities (8:51) Cerebral Amyloid Angiopathy and the Blood-Brain Barrier (15:47) Therapeutic Avenues (24:00) -------------------------------------------------------------- To find the numbered bibliography with al...2022-10-1329 min
AMiNDR: A Month in Neurodegenerative Disease Research299 - Cognitive Assessment in Alzheimer's Disease Part 2: June 2022We promised you we would be back with more on clinical assessment for Alzheimer’s disease, and here we are to deliver. Stick around to hear about papers published in June 2022 on validating variations of the Montreal Cognitive Assessment, tracking Activities of Daily living, and digital tools for assessing cognition. Our harvest yielded 7 abstracts, all presented in this episode! Sections in this episode: Combinign Multiple Neurocognitive Domains (7.00) Activities of Daily Living (14.00) Digital Tools & Automation (18.30) -------------------------------------------------------------- To find the numbered bibliography with all the papers covered in this e...2022-09-1529 min
AMiNDR: A Month in Neurodegenerative Disease Research297 - Genetic Insights for Alzheimer's Disease: June 2022In this episode, Joseph covers papers published in June 2022 on GWAS studies, transcriptomics, genetic and genomic studies and the like on Alzheimer’s disease. Stay tuned! Sections in this episode: Genetic & Disease Overlaps (2:15) RNA & Transcriptomics (5:10) Genetic Testing (10:25) GWAS Studies (15:24) Specific Genes (21:04) Extra (28:55) -------------------------------------------------------------- To find the numbered bibliography with all the papers covered in this episode, click here, or use the link below:https://drive.google.com/file/d/1diNBktrzfDyUcmjSUiItcdRUNbxEAcNl/view?usp=sharingTo access the folder with ALL ou...2022-09-0632 min
AMiNDR: A Month in Neurodegenerative Disease Research294 - Cognitive Assessment in Alzheimer's Disease Part 1: June 2022You are here, with us, right now, about to get the updates you eagerly wait for every month in Alzheimer’s disease research. A whole episode dedicated to assessing neurocognitive domains for screening and diagnostics. Learning and memory? Executive function? Perceptual and motor skills? You got it! 7 abstracts published in June 2022, nicely packaged for you in this podcast. Sections in this episode: Learning & Memory (7:41) Executive Function (26:18) Perceptual-Motor (28:25) -------------------------------------------------------------- To find the numbered bibliography with all the papers covered in this episode, click here, or use the link below:2022-08-2635 min
AMiNDR: A Month in Neurodegenerative Disease Research293 - Vascular Changes in Alzheimer's Disease: June 2022Ever thought there was more to Alzheimer disease than the plaques and tangles? You've come to the right place. Join Elyn for a guide through the latest research on vascular contributions to Alzheimer disease. June 2022 brought lots of new insight into how vascular hallmarks interact with the classic AD hallmarks to influence cognition, emphasis on vascular pathology in familial Alzheimer disease, and so much more. Tune in for a riveting episode! Sections in this episode: Cardiovascular Risk Factors (4:06) Interactions of Vascular Pathology with AD Hallmarks (6:58) Vascular Abnormalities in Familial AD (12:28) APO...2022-08-2428 min
AMiNDR: A Month in Neurodegenerative Disease Research292 - Synaptic Transmission in Alzheimer's Disease: June 2022We are kicking off our June 2022 series of episodes with this short and sweet episode. Anusha takes a look at papers published on the subject of changes to synaptic transmission and neuronal excitability in Alzheimer’s disease. If you're interested in bridging the gap between changes to neuronal function and behavioural consequences, this episode is a great place to start! Sections in this episode: Changes to neurotransmission and neuronal excitability (2.44) Changes to movement/learning and memory (11.06) -------------------------------------------------------------- To find the numbered bibliography with all the papers covered in this episode...2022-08-2317 min
AMiNDR: A Month in Neurodegenerative Disease Research291 - Vascular Contributions to Alzheimer's Disease: May 2022Elyn is back with a short and sweet episode on the latest research on vascular contributions to Alzheimer disease! Tune in for a quick recap of May 2022 research, and a disease perspective a bit more lively than the classic amyloid cascade hypothesis! Clinical Studies (3:53)Preclinical Studies/Methology (12:41) -------------------------------------------------------------- To find the numbered bibliography with all the papers covered in this episode, click here, or use the link below: https://drive.google.com/file/d/1ykvbecZO_b3jUyCRc-LG6hgj2ORitxKT/view?usp=sharin...2022-08-0120 min
AMiNDR: A Month in Neurodegenerative Disease Research288 - New Variants and Genetic Insights Part 1: May 2022In this episode, Joseph is back to go over papers published in May 2022 on GWASs, genetics or any other genetics-focused work. Topics include GWAS's, tool development, gene discovery, and social performance-based genetic studies! GWAS and Polygenic Risk Scores (2:20)Cognitive & Social Genetic Studies (8:42)Tool development (11:46)Gene Discovery (14:41)Studies on Amyloid and Tau (16:09) -------------------------------------------------------------- To find the numbered bibliography with all the papers covered in this episode, click here, or use the link below: https://drive.google.com...2022-07-2522 min
AMiNDR: A Month in Neurodegenerative Disease Research287 - Cognitive Assessment in Alzheimer's Disease: May 2022Welcome welcome! This episode was made for you if you are interested in geriatrics, neurology, or cognitive testing in general, as we will go through the latest publication on clinical assessment of cognitive decline. That’s right, 9 papers published in May 2022 on testing neurocognitive domains for the screening or diagnosis of mild cognitive impairment, Alzheimer’s disease, or dementia in general. Learning and Memory (7:17)Perceptual and Motor Skills (20:23)Language (22:33)Activities of Daily Living (27:56) -------------------------------------------------------------- To find the numbered bibliography with all the paper...2022-07-2236 min
AMiNDR: A Month in Neurodegenerative Disease Research286 - Synaptic Transmission in Alzheimer's Disease: May 2022AMiNDR is back and excited to bring you more literature on Alzheimer’s Disease. In this episode, we’ve got papers published in May of 2022 on the subject of changes to synaptic transmission and neuronal excitability. Anusha covers subjects like calcium homeostasis, synaptic function, and how to translate findings to humans and human models, so join her if your neurons are excited by the topic! Sections in this episode: Calcium Homeostasis (2:54) Synaptic Function in Animal Models (5:26) Human Models (10:28) -------------------------------------------------------------- To find the numbered bibliograph...2022-07-2016 min
AMiNDR: A Month in Neurodegenerative Disease Research284 - Cognitive Assessment in Alzheimer's Disease Part 2: March 2022Welcome back for the second of a 2-part episode on the clinical assessment of Alzheimer’s disease, based on abstracts published in March 2022! You will hear about the evaluation of traditional and digital tests for their potential to help us detect AD and distinguish it from MCI. Also on the menu, a few papers on markers of cognitive decline that may help us refine our diagnosis, or even for prognostic purposes. Yes, you read this correctly, all this goodness packed in 1 episode! Sections in this episode: Evaluating Existing Tests (7:31) Identifying Markers for Cognitive Decli...2022-06-0636 min
AMiNDR: A Month in Neurodegenerative Disease Research283 - Cognitive Assessment in Alzheimer's Disease Part 1: March 2022This is our monthly update on clinical assessment of Alzheimer’s disease, based on abstracts published in March 2022! This is the first of a 2-part series on the matter, where we bring together ways to assess cognitive function by looking at one neurocognitive domain, such as learning and memory, language, perceptual-motor skills, and even by looking at activities of daily living. This is perfect for you if you are researching cognition, or are interested in Neurology or Geriatrics in general! Sections in this episode: Learning & Memory (6:40) Language (14:48) Perceptual-Motor (20:43) Attention (23:44) Oth...2022-05-2831 min
AMiNDR: A Month in Neurodegenerative Disease Research280 - Treatments Targeting Neuroprotection in Alzheimer's Disease: February 2022In February of 2022, 8 papers were published on the topic of using neuroprotective compounds as treatment for AD. Anusha will guide you through these papers exploring the entire drug discovery pipeline, from discovery to clinical trials. Sections in this episode: Drug Discovery (2.01) Drug Development (4.59) Clinical Trials (11.58) -------------------------------------------------------------- To find the numbered bibliography with all the papers covered in this episode, click here, or use the link below:https://drive.google.com/file/d/1zzsck-2adMbZB8_cYV6B-AyOwd2p_gqt/view?usp=sharingTo access the fo...2022-04-3017 min
AMiNDR: A Month in Neurodegenerative Disease Research279 - Treatments Targeting the Immune System in Alzheimer's Disease: February 2022February 2022 was full of abstracts using unique therapeutic approaches to target Alzheimer's disease. Cassi presents abstracts on both naturally-occurring and pharmaceutical compounds used to treat various neurodegenerative pathology and symptoms. Sections in this episode: Microbiome (1:55) NF-kappaB signaling pathway (6:12) Sexual dimorphism (11:34) Naturally-occurring & pharmaceutical treatments (15:37) -------------------------------------------------------------- To find the numbered bibliography with all the papers covered in this episode, click here, or use the link below:https://drive.google.com/file/d/1kMrWRHBkkRqSrR9XzuEFbfquLGbb26Qe/view?usp=sharingTo access the folder with ALL our...2022-04-2829 min
AMiNDR: A Month in Neurodegenerative Disease Research278 - Risk Factors for Alzheimer's Disease Part 1: February 2022In today's episode, Naila will guide you through 19 papers from February 2022 on the prevalence and incidence of Alzheimer's disease in various study populations, social determinants of health, as well as environmental and lifestyle factors that may influence the risk of dementia. Part 2 will be available as a bibliography, which you can find in our show notes or at www.amindr.com! Sections in this episode: Epidemiological Studies (1:56) Racial/Ethnic Disparities (11:50) Social Determinants (25:24) Lifestyle and Environmental Factors (31:44) -------------------------------------------------------------- To find the numbered bibliography with all the papers...2022-04-2642 min
AMiNDR: A Month in Neurodegenerative Disease Research277 - Cognitive Assessment in Alzheimer's Disease Part 2: February 2022Welcome back for the continuation of our segment on clinical assessment. You heard about testing specific neurocognitive domains in part 1, and here we’re back to cover abstracts that look at the big picture in assessing cognitive function. We’re presenting 8 abstracts published in February 2022, perfect for you if you’re interested in tracking cognitive decline for the diagnosis of Alzheimer’s disease, Mild Cognitive Impairment, or dementia in general. Sections in this episode: Considerations and Limitations in Testing (3.06) The Big Picture (13.30) -------------------------------------------------------------- To find the numbered bibliography with all the papers co...2022-04-2334 min
AMiNDR: A Month in Neurodegenerative Disease Research276 - Cognitive Assessment in Alzheimer's Disease Part 1: February 2022If you wanted to detect and diagnose Alzheimer’s disease, or assess disease progression, what aspects of cognition would you focus on? In other words, what capabilities would you test to decide if someone is indeed experiencing cognitive decline, had Alzheimer’s disease, or another type of dementia? And what tools could you use? Stay with me to hear about the abstracts dedicated to specific cognitive domains in the clinical assessment of cognitive impairment, published in February 2022! Sections in this episode: Learning and Memory (6.04) Language (21.42) -------------------------------------------------------------- To find the numbered...2022-04-2331 min
AMiNDR: A Month in Neurodegenerative Disease Research275 - Prevention and Intervention Strategies for Alzheimer's Disease: February 2022This month's episode covers a range of interventions and non-pharmacological treatments that could help prevent or live with AD. Naila will take you through the various mechanisms underlying the impact of different lifestyle interventions, the potential therapeutic effects of exercise, what mushroom consumption and ketogenic diets might have to offer, and plenty of other stimulating topics! Sections in this episode: Cognitive and Multidomain Interventions (1:35) Diet (7:42) Exercise (12:00) Neuromodulatory Techniques (26:20) -------------------------------------------------------------- To find the numbered bibliography with all the papers covered in this episode, click here, or use the...2022-04-2043 min
AMiNDR: A Month in Neurodegenerative Disease Research274 - Vascular Contributions to Alzheimer's Disease: February 2022Ever wondered how amyloid deposited in cerebral vessels might affect cerebrovascular reactivity? Or how the culture time of iPSC-derived brain microvascular endothelial-like cells changes their phenotype? Well, you've come to the right place. Elyn will take you through all this and more as she emphasizes the importance of cerebrovascular health in the context of Alzheimer disease in this episode covering papers published on PubMed in February 2022. Sections in this episode: Clinical Insights: Neuroimaging and Vascular Risk Factors (3:51) Preclinical Insights: Methodology and BBB Regulation (25:47) Treatment Avenues (32:19) -------------------------------------------------------------- To find t...2022-04-1937 min
AMiNDR: A Month in Neurodegenerative Disease Research271 - Vascular Contributions to Alzheimer's Disease: January 2022With her first episode covering papers from 2022, Elyn is back with a lot of new and interesting findings implicating blood-brain barrier dysfunction in Alzheimer disease. Tune in to hear about this and much more in this longer episode covering 15 papers published in January 2022! Sections in this episode: Clinical Insights - Vascular Risk Factors (3:46) Blood-Brain Barrier Dysfunction (9:41) Amyloid Deposition and Clearance (30:31) Treatment Avenues (35:22) -------------------------------------------------------------- To find the numbered bibliography with all the papers covered in this episode, click here, or use the link below:https...2022-03-2940 min
AMiNDR: A Month in Neurodegenerative Disease Research268 - Prevention and Intervention Strategies for Alzheimer's Disease: January 2022Today's episode will take you all the way from the molecular to the human level in 16 papers on non-pharmacological approaches for preventing or treating Alzheimer's disease. Naila will guide you through the latest research on exercise in AD mouse models, nutritional supplements that could decrease the risk of AD, the potential therapeutic effects of repetitive transcranial magnetic stimulation, and more! Sections in this episode: Interventions Targeting Cognition (1.50) Multidomain Interventions (7.36) Nutrition (13.30) Exercise (19.06) Stimulatory Techniques (25.23) -------------------------------------------------------------- To find the numbered bibliography with all the papers covered...2022-03-2239 min
AMiNDR: A Month in Neurodegenerative Disease Research266 - Risk Factors for Alzheimer's Disease: December 2021Discover the latest on risk and protective factors of AD, from the perspective of 18 observational studies published in December 2021. Naila will take you through socioeconomic factors, nutrition, exercise, and various comorbidities related to AD. Sections in this episode: Prevalence and Socioeconomic Factors (1:45) Nutrition (13:11) Health-Related Factors (18:49) -------------------------------------------------------------- To find the numbered bibliography with all the papers covered in this episode, click here, or use the link below:https://drive.google.com/file/d/15gMFkpU55HqCYCSQMYvaVgVngdY9j8DT/view?usp=sharingTo access the folder with a...2022-03-0836 min
AMiNDR: A Month in Neurodegenerative Disease Research263 - Vascular Contributions to Alzheimer's Disease: December 2021Tired of the amyloid cascade hypothesis? Think there's more to AD than the plaques and tangles? You've come to the right place! Elyn is back for her final episode covering papers from 2021 on Vascular Contributions to Alzheimer Disease. Tune in to hear about the latest findings relating to cerebrovascular changes in AD, and why they matter. Sections in this episode: Insights from Clinical Studies (4:10) Insights from Animal Models (14:47) -------------------------------------------------------------- To find the numbered bibliography with all the papers covered in this episode, click here, or use the link below:...2022-02-2424 min
AMiNDR: A Month in Neurodegenerative Disease Research260 - Clinical Assessment in Alzheimer's Disease Part 1: December 2021Can smell, gaze, blinking rate, or handwriting offer a window into what happens inside the Alzheimer’s disease brain? Are there parameters we can add to our batteries for assessing cognitive decline in a clinical setting? Missed opportunities in cognitive assessment? Maybe. This episode is dedicated to all kinds of variables that can help orient ourselves on the Alzheimer’s disease continuum, and perhaps predict the progression from MCI to AD. Sections in this episode: Non-Cognitive Variables (6.27) Cognitive Variables (20.28) -------------------------------------------------------------- To find the numbered bibliography with all the papers covered i...2022-02-1830 min
AMiNDR: A Month in Neurodegenerative Disease Research257 - Risk Factors for Alzheimer's Disease: November 2021Naila's back with 19 epidemiological and observational studies published in November 2021. It's quite the panoply of topics - you'll hear about marital status, air pollution, metabolic syndrome, medication use and more. We hope you enjoy! Sections in this episode: Epidemiological and Environmental (1.44) Vaccine/Medication Use (15.10) Psychomotor (22.48) Metabolic Comorbidities (26.18) Other Comorbidities (31.11) -------------------------------------------------------------- To find the numbered bibliography with all the papers covered in this episode, click here, or use the link below:https://drive.google.com/file/d/1Sv1PUzE2PV2lppDwY2-lPMTReLWaPux5/view?usp...2022-02-1039 min
AMiNDR: A Month in Neurodegenerative Disease Research256 - Autophagy and Proteostasis in Alzheimer's Disease: November 2021Tired of only hearing about tau or a-beta when it comes to AD research? Take a peek behind the scenes with Kate to explore the latest on the proteostasis and autophagy pathways that work to safeguard our cells in 13 papers from November 2021. Sections in this episode: Autophagy & Proteostasis Pathology (4:17) Targeting Proteostasis/Autophagy Machinery (22:21) -------------------------------------------------------------- To find the numbered bibliography with all the papers covered in this episode, click here, or use the link below:https://drive.google.com/file/d/1qO6ISzG2igk1NtzKi19x08Dw4wO7FNeQ...2022-02-0828 min
AMiNDR: A Month in Neurodegenerative Disease Research253 - Vascular Contributions to Alzheimer's Disease: November 2021Interested in a fresh perspective on the etiology of AD? Join Elyn for her monthly tour through the new research on vascular contributions to Alzheimer disease! Whether this is your niche field, or you want to look at the disease through a new lens, this episode is perfect for you. Tune in to hear about endothelial cell biology, a phase 2 clinical trial, and several animal models! Sections in this episode: Endothelial Cell Biology & Amyloid Clearance (4:40) Insights from Animal Models (8:44) Insights from Human Studies (13:49) -------------------------------------------------------------- To find the number...2022-01-3123 min
AMiNDR: A Month in Neurodegenerative Disease Research252 - Clinical Assessment of Alzheimer's Disease: November 2021Welcome all researchers, students, and clinicians who are interested in learning about clinical testing for Alzheimer’s disease! This episode is dedicated to papers published back in November 2021 on new and old assessment methods to help in the diagnosis of Alzheimer’s. This includes testing cognitive processes and performance on activities of daily living, detecting Alzheimer’s, and distinguishing it from other dementias. You will hear about some new cognitive and non-cognitive parameters to consider as well, so tune in for your monthly fill of news in the field! Sections in this episode: Existing cognitive tests (7...2022-01-2937 min
AMiNDR: A Month in Neurodegenerative Disease Research246 - Risk Factors for Alzheimer's Disease Part 1: October 2021In Part 1 of our episode on epidemiological studies from October 2021, Naila will cover 11 papers on demographic and socioeconomic factors related to dementia and Alzheimer's disease. You'll hear a lot on subjective cognitive decline, education and occupation. Enjoy, and be sure to check out Part 2! Sections in this episode: Prevalence and Demographics (1:33) Education (7:51) Socioeconomic status and occupation (14:13) Other (23:38) -------------------------------------------------------------- You can find the numbered bibliography for this episode by clicking here, or the link below: https://drive.google.com/file/d/1PTf3HweI53JJNntYHZlSRjfcJFuOcLJW/view?usp...2022-01-1226 min
AMiNDR: A Month in Neurodegenerative Disease Research244 - Vascular Contributions to Alzheimer's Disease: October 2021Elyn is back with your monthly update on vascular contributions to Alzheimer disease! This month she covers 8 papers that primarily focus on the blood-brain barrier, and white matter hyperintensities that reflect cerebrovascular abnormalities. Tune in for some exciting new findings in the field and more data emphasizing the importance of vascular health in dementia. Sections in this episode: White Matter Hyperintensities (4:13) Blood-Brain Barrier (13:57) Cerebral Amyloid Angiopathy (20:02) -------------------------------------------------------------- You can find the numbered bibliography for this episode by clicking here, or the link below: https://drive.google...2022-01-0723 min
AMiNDR: A Month in Neurodegenerative Disease Research238 - Brain Imaging of Structural Changes in Alzheimer's Disease: October 2021We have 14 papers in this episode using structural magnetic resonance imaging (sMRI) in the diagnosis or prognosis of Alzheimer's Disease. Join Christy as she walks you through some deep learning based frameworks and other automated models, as well as new findings with grey matter atrophy. Sections in this episode: Deep Learning (2:38) Automated Algorithms & Models (8:24) Grey Matter (17:20) Others - White matter and the Retina (25:00) -------------------------------------------------------------- You can find the numbered bibliography for this episode by clicking here, or the link below:https://drive.google.com/fil...2021-12-1731 min
AMiNDR: A Month in Neurodegenerative Disease Research235 - Vascular Contributions to Alzheimer's Disease: September 2021Feeling like we're beating a dead horse with the amyloid cascade hypothesis? Think there's an X-factor to Alzheimer disease that is tied to both the clinical symptoms and the plaques? Could be the vasculature! Elyn is back to take you through the 12 papers published on vascular contributions to Alzheimer disease, and hopefully get you excited about this blossoming line of research and the new treatment avenues that come with it. Sections in this episode:White Matter Hyperintensities Amyloid Transport and Clearance Mechanistic Insights from Rodent Models Treatment Avenues ...2021-12-1129 min
AMiNDR: A Month in Neurodegenerative Disease Research234 - Clinical Markers for Alzheimer's Disease Part 2: September 2021Were you looking to learn about clinical testing for Alzheimer’s disease? This is Part 2 of our monthly episode on cognitive and clinical markers for diagnostic and prognostic purposes. Come learn about tests for psychomotor, visuospatial and motor abilities, as well as genetic screens for detecting AD. You will also learn about new cognitive tests for for distinguishing AD from other dementias, or detecting MCI and AD, something we are working towards so we can intervene earlier. All from our harvest of publications from the month of September 2021. Sections in this episode:Non-Cognitive Parameters to Inc...2021-12-0941 min
AMiNDR: A Month in Neurodegenerative Disease Research233 - Clinical Markers of Alzheimer's Disease Part 1: September 2021You may have come across a variety of exams used to test cognitive function and assess cognitive decline, such as the Addenbrooke's Cognitive Examination, the mini mental state exam, the clock drawing test, and many more. So how are we doing with these? And how well do they apply in special populations such as people with intellectual disability? Is there room for racial bias in how they are administered? And what translated tests were recently validated? These are topics addressed by papers published in September 2021 in the context of Alzheimer’s disease, presented in the first of this 2-part ep...2021-12-0754 min
AMiNDR: A Month in Neurodegenerative Disease Research232 - Prevention & Intervention Strategies for Alzheimer's Disease : September 2021This episode is short and sweet, covering 7 papers on cognitive training, exercise and stimulation techniques. Naila will guide you through the latest in animal models and underlying mechanisms for these potential non-pharmacological interventions. Sections in this episode:Cognitive Training (2:06) Exercise (4:23) Stimulation Techniques (11:38)-------------------------------------------------------------- You can find the numbered bibliography for this episode by clicking here, or the link below:https://drive.google.com/file/d/1PjokO3cFgLOjtRyi9yjQlckHRNKMtiEM/view?usp=sharingTo access the folder with all the bibliographies for 2021 so far, follo...2021-12-0417 min
AMiNDR: A Month in Neurodegenerative Disease Research231 - Understanding Cognitive & Behavioural Changes in Alzheimer's Disease: September 2021Ellen tells you about research on topics such as cognitive reserve, reinforcement learning, psychiatric conditions, sleep issues, speech, and more in this jam-packed episode on cognitive and behavioural changes in Alzheimer's Disease. Sections in this episode: General Cognition (3:32) Reinforcement Learning (14:09) Speech and Language (16:33) Visuospatial and Motor Control (25:06) Psychiatric Changes (28:15) Sleep and Circadian Rhythms (35:16) -------------------------------------------------------------- You can find the numbered bibliography for this episode by clicking here, or the link below:https://drive.google.com/file/d/1PjokO3cFgLOjtRyi9yjQlckHRNKMtiEM/view?usp=s...2021-12-0243 min
AMiNDR: A Month in Neurodegenerative Disease Research230 - Risk Factors for Alzheimer's Disease Part 2: September 2021Back for part 2, Naila takes you through 15 papers pertaining to health conditions associated with AD and dementia. You'll hear about infections, cardiovascular and metabolic risk factors, and a few miscellaneous diseases. Sections in this episode: Epidemiology / Multiple Factors (1:00) Immune Conditions (8:00) Metabolic and Cardiovascular (15:00) Neurological Comorbidities (24:50) -------------------------------------------------------------- You can find the numbered bibliography for this episode by clicking here, or the link below:https://drive.google.com/file/d/1Pgl18mXwvDG2xZK9fijICMtfEhI7BXUG/view?usp=sharingTo access the folder with all the...2021-11-3031 min
AMiNDR: A Month in Neurodegenerative Disease Research229 - Risk Factors for Alzheimer's Disease Part 1: September 2021In today's episode, Naila takes you through 10 papers on risk factors associated with Mild Cognitive Impairment, Alzheimer's and dementia. You'll hear a little on lifestyle factors, air and noise pollutants, and hormones. Stay tuned for Part 2! Sections in this episode: Lifestyle & Environmental Factors (2:09) Hormones (15:13) -------------------------------------------------------------- You can find the numbered bibliography for this episode by clicking here, or the link below:https://drive.google.com/file/d/1BUfTeMbAC0HzYcXRieJSQdsoNKS9r2J7/view?usp=sharingTo access the folder with all the bibliographies for 2021 so far, follo...2021-11-2721 min
AMiNDR: A Month in Neurodegenerative Disease Research228 - New Variants & Genetic Insights in Alzheimer's Disease: September 2021Join Glory to learn about the newest genetic variants and mechanisms that have been linked to Alzheimer's disease. In this episode, we'll cover protective and pathogenic AD variants in genes, potential genetic biomarkers for AD, and differential gene expression that can be observed in individuals with AD. With 19 papers from September 2021, you'll hear about some genes that will be worth following up on in the near future to advance our understanding of the disease! Sections in this episode: Genetic variants (3:11) Genetic biomarkers (13:58) Differential gene expression and mRNA (18:05) miRNA regulations (22:55) N...2021-11-2537 min
AMiNDR: A Month in Neurodegenerative Disease Research227 - Autophagy & Proteostasis in Alzheimer's Disease: September 2021Tune into this month's episode on the latest research on autophagy and proteostasis in Alzheimer's Disease. This includes papers on how autophagy and protein homeostasis are dysfunctional in this disease, and potential treatments that target these cellular pathways. Enjoy! Sections in this episode: Proteostatic and autophagic dysregulation (4:33) RNA splicing, binding, and signaling (10:32) Glycans, glycoproteins, and fatty acids (19:29) Amyloid precursor protein (24:16) Targeting Proteostasis/Autophagy Machinery (26:55) -------------------------------------------------------------- You can find the numbered bibliography for this episode by clicking here, or the link below:https...2021-11-2332 min
AMiNDR: A Month in Neurodegenerative Disease Research226 - Treatments Targeting Mitochondria & Metabolism in Alzheimer's Disease: September 2021Let’s take a trip with Vee through the latest literature to the mitochondria and learn about oxidative stress, metabolism and related therapeutics in Alzheimer’s disease pathology. A jam packed session from vitamins to energy homeostasis to metal chelators- this episode has it all! We have 10 publications from September 2021, which will surely “power” your interest. Tune in and get ready to charge up on the exciting research! Sections in this episode: Metabolism (4:26) Mitochondria (11:45) Oxidative Stress (19:47) -------------------------------------------------------------- You can find the numbered bibliography for this episode by clicking here...2021-11-1929 min
AMiNDR: A Month in Neurodegenerative Disease Research225 - Detecting Amyloid, Tau and New Markers in the Brain in Alzheimer's Disease: September 2021Let's take a closer look at 18 papers published in September 2021 that rely on positron emission tomography (or PET) to detect amyloid and tau pathology in the brain, within the context of Alzheimer's disease! If you're interested in learning about tau and amyloid based detection, alternative PET tracers in AD research, or combining PET with different imaging modalities, make sure to tune into this episode. Sections in this episode: Amyloid-based detection (2.35) Tau-based detection (9.35) Amyloid & Tau (21.30) Other targets (24.25) -------------------------------------------------------------- You can find the numbered bibliography for this episode...2021-11-1829 min
AMiNDR: A Month in Neurodegenerative Disease Research224 - Tau Protein Pathology in Alzheimer's Disease: September 2021Tired of untangling the tricky world of tau literature all on your own? Interested in the mechanisms of tau pathology, therapeutic advancements targeting tau, or both? Join Kate for another exciting episode covering 20 new papers published in September 2021. We’ll explore tau aggregation, regulation, and treatment development through a wide variety of model systems, from molecular dynamics all the way to human subjects - so, tune in to learn more! Sections in this episode: New tau pathological findings (3.17) Tau and Neuroinflammation (7.46) Tau Aggregation (10.24) Tau Pathology from Prion-like Seeding Behaviour (13.24) Tre...2021-11-1636 min
AMiNDR: A Month in Neurodegenerative Disease Research223 - Treatments Targeting Neurotransmission in Alzheimer's Disease: September 202118 papers published in September of 2021 await you. What do they all have in common? They explore treatments for Alzheimer's disease that all target neurotransmission. If you're interested in restoring acetylcholine balance or other treatments that also improve cognitive function in Alzheimer's disease, tune in to hear Anusha take you through the literature. Sections in this episode: Discovery and synthesis of novel cholinesterase inhibitors (3.17) Tacrine-based cholinesterase inhibitors (11.26) Modifying existing treatments (16.16) Multi-target treatments (23.00) -------------------------------------------------------------- You can find the numbered bibliography for this episode by clicking here, or the lin...2021-11-1227 min
AMiNDR: A Month in Neurodegenerative Disease Research222 - Changes to Synaptic Transmission in Alzheimer's Disease: September 2021Are you interested in neuronal hyperexcitability, impairments in synaptic plasticity, and interactions between amyloid plaques and synaptic proteins in Alzheimer's disease pathology? You've come to the right podcast! In this episode, Glory will guide you through 11 publications from September 2021 on the latest research about the mechanisms of synaptic transmission and plasticity that contribute to the Alzheimer's disease. Hit that play button to hear all of the exciting new insights on the AD synapse. Sections in this episode: Neurotransmitters systems involved in AD (2:56) Neuronal structure (11:42) Neuron Excitability (14:33) Amyloid beta and APP a...2021-11-1126 min
AMiNDR: A Month in Neurodegenerative Disease Research221 - Treatments Targeting Synaptic & Neuronal Protection in Alzheimer's Disease: September 2021The first episode of our September 2021 series gets us acclimated with papers that target neuronal and synaptic function in preclinical studies of Azheimer's disease. Join Anusha and she walks you through papers that explore topics like rescuing amyloid beta-induced toxicity, restoring neuronal morphology, and using animal models of Alzheimer's disease to target neuronal function. Sections in this episode: Targeting A-Beta-Induced Toxicity (2.21) Restoring Neuronal Morphology and Promoting Neurogenesis (7.26) Restoring Neuronal Function in AD Animal Models (15.40) -------------------------------------------------------------- You can find the numbered bibliography for this episode by clicking here, or the...2021-11-0823 min
AMiNDR: A Month in Neurodegenerative Disease Research220 - Clinical Markers of Alzheimer's Disease Part 2: August 2021This is part 2 of our episode on clinical markers for Alzheimer’s disease, where we cover papers published in August 2021. How does a translation of your favourite cognitive test perform in a Chinese, Slovenian or Persian population? What measures are we currently ignoring but should be include in our battery of tests to detect Alzheimer’s disease or mild cognitive impairment? There is new stuff on this regularly, so come get your monthly fill of research news, maybe you’ll find a gem that will influence your practice, in research or in the clinic. Sections in this episode...2021-11-0432 min
AMiNDR: A Month in Neurodegenerative Disease Research219 - Clinical Markers of Alzheimer's Disease Part 1: August 2021Do you want to brush up on your knowledge of MoCA, ADAS-Cog, the MMSE and other cognitive tests? Join Sarah to hear about the 7 papers published in August 2021 where we’re evaluating existing tests for their specificity and sensitivity in detecting Alzheimer's disease and mild cognitive impairment. -------------------------------------------------------------- You can find the numbered bibliography for this episode by clicking here, or the link below:https://drive.google.com/file/d/1w5W2UPrmR7vRgFtjsWj4KBMXh3qhFHoN/view?usp=sharingTo access the folder with all the bibliographies for 2021 so fa...2021-11-0228 min
AMiNDR: A Month in Neurodegenerative Disease Research218 - Cognitive and Behavioural Changes in Alzheimer's Disease: August 2021In today's episode of AMiNDR, we’ll be talking about the latest work on cognitive and behavioural changes in Alzheimer's Disease, including papers on executive functioning, depression, social impairments, motor coordination, and more. Join Ellen as she guides you through 18 papers on the mechanisms behind cognition and other neuropsychological symptoms in AD! Sections in this episode: Cognitive Profiles (4:07) Executive Functions (13:06) Exercise & Cognition (18:12) Psychiatric & Social Symptoms (21:54) Motor Coordination & Balance (34:09) Sleep & Circadian Rhythms (35:52) -------------------------------------------------------------- You can find the numbered bibliography for this epi...2021-10-3041 min
AMiNDR: A Month in Neurodegenerative Disease Research216 - Familial Mutations, New Variants & More Genetic Insights: August 2021Buckle down and get ready for a lengthy episode on the most recently discovered familial mutations and variants related to Alzheimer's disease. With Glory as your host, we'll take a look at different variants in genes that may make you more or less susceptible to developing AD. A large chunk of the episode will cover single nucleotide polymorphisms that have been found in various populations and correlate with neurodegenerative disease. You’ll also hear about genetic mutations in patients or families that researchers have linked to familial AD. Sections in this episode: SNPs and r...2021-10-2635 min
AMiNDR: A Month in Neurodegenerative Disease Research214 - Risk Factors for Alzheimer's Disease: August 2021Make yourself comfortable, because we cover a lot of ground in today's episode. Naila will guide you through 24 papers from August 2021, all pertaining to epidemiological studies on the risk and protective factors related to AD. You'll hear about some basic epidemiology, environmental and socioeconomic risk factors, lifestyle factors, and health conditions related to AD. Sections in this episode: Epidemiology & Social Factors (1.52) Diet (16.53) Sleep (24.19) Comorbidities (28.00) -------------------------------------------------------------- You can find the numbered bibliography for this episode by clicking here, or the link below:https://drive.google...2021-10-2147 min
AMiNDR: A Month in Neurodegenerative Disease Research213 - Vascular Contributions to Alzheimer's Disease: August 2021Tired of the age-old amyloid cascade hypothesis? Think there's more to Alzheimer disease than amyloid and tau? Join Elyn in unpacking the latest literature on vascular contributions to Alzheimer disease from papers published in August 2021. This is another relatively short one, packed with exciting new insights! Sections in this episode: Cardiovasular Risk Factors (4:30) White Matter Hyperintensities and Cerebral Small Vessel Disease (8:28) Vascular Changes: Perivascular Spaces, Pericyte Coverage, & Vessel Density (16:22) -------------------------------------------------------------- You can find the numbered bibliography for this episode by clicking here, or the link be...2021-10-1926 min
AMiNDR: A Month in Neurodegenerative Disease Research206 - Prevention & Intervention Strategies in Alzheimer's Disease: July 2021Today's episode covers 18 papers on prevention and intervention strategies for Alzheimer's disease and dementia. Naila will take you through clinical trials and animal studies on cognitive training programs, complementary therapies, diet, exercise, and neuromodulatory techniques. There's a lot of unique papers in this one, so we hope you enjoy! Sections in this episode: Cognitive Training (2:52) Complementary Therapies (6:08) Diet (15:30) ; Exercise (19:56) Neuromodulatory Techniques (28:51) -------------------------------------------------------------- You can find the numbered bibliography for this episode by clicking here, or the link below:https://drive.google.c...2021-09-2336 min
AMiNDR: A Month in Neurodegenerative Disease Research205 - Treatments targeting neurotransmission in Alzheimer's Disease: July 2021Journey through the entire spectrum of drug development as Anusha guides you through 19 papers that were published in July of 2021. We span research that begins with drug discovery all the way to the end goal: Phase II clinical trials. If you're interested in targeting levels of acetylcholine and monoamines, you're really going to like this episode! Sections in this episode: Synthesis and Discovery of Cholinesterase Inhibitors (2.47) Drug Interactions with Multiple targets (9.29) Pre-clinical Trials (18.23) Clinical Trials (25.39) -------------------------------------------------------------- You can find the numbered bibliography for this...2021-09-2230 min
AMiNDR: A Month in Neurodegenerative Disease Research204 - Clinical Markers of Alzheimer's Disease Part 2: July 2021In this episode, Ellen tells you about 9 papers that have developed new ways to screen for dementia. Some of these are old, tried-and-true cognitive screening tools that are given a new twist, others are brand new technology that bring cognitive testing to the modern age. You’re sure to find something you enjoy in this episode if you do neurodegenerative disease research, or even if you don’t! Sections in this episode: Technology-based tools (3:44) Adapting tests to other languages (8:34) Other new tools for testing cognition (12:22) -------------------------------------------------------------- You ca...2021-09-2121 min
AMiNDR: A Month in Neurodegenerative Disease Research203 - Clinical Markers of Alzheimer's Disease Part 1: July 2021In the first part of this 2-parter episode, Ellen covers studies that compare and contrast different cognitive tests, or analysis techniques, for diagnosing AD at early stages, or predicting the conversion of pre-dementia stages to Alzheimer’s Disease. There are also some studies that compare cognitive abilities between different types of dementia. You'll hear about memory, spatial awareness, social cognition, and more! Sections in this episode: Cognitive decline & memory (3:32) Semantic fluency (16:42) Social cognition (18:21) Spatial awareness (21:47) -------------------------------------------------------------- You can find the numbered bibliography for this e...2021-09-1725 min
AMiNDR: A Month in Neurodegenerative Disease Research202 - Tau protein pathology in Alzheimer's Disease: July 2021Kate brings you the latest research on tau pathology in Alzheimer's Disease. This includes post-translational modifications, tau aggregation and seeding, and targeting tau in treatment development. Enjoy! Sections in this episode: Tau Pathology (4:35) Post-translational modifications (4:56) Tau aggregation and seeding behaviour (16:30) Targeting Tau for Treatment Development (21:09) -------------------------------------------------------------- You can find the numbered bibliography for this episode by clicking here, or the link below:https://drive.google.com/file/d/1xBMvUdqdBPnGQDnv9qBk9icbKBNEbdXZ/view?usp=sharingTo access the folde...2021-09-1626 min
AMiNDR: A Month in Neurodegenerative Disease Research201 - Vascular Contributions to Alzheimer's Disease: July 2021Interested in how the 700km of blood vessels in the brain are linked to Alzheimer disease? Turns out there are a lot of common threads! In this episode, Elyn covers a series of clinical and preclinical papers exploring vascular risk factors, genetic risk factors like APOE, and signs of vascular damage that are linked to Alzheimer disease. Tune in for an exciting perspective on Alzheimer disease, outside of the classic amyloid cascade hypothesis! Sections in this episode: Clinical Studies: Cardiovascular Risk Factors and Cerebrovascular Pathology (4:22) Lymphatic/Glymphatic Drainage (13:48) Preclinical Modell...2021-09-1522 min
AMiNDR: A Month in Neurodegenerative Disease Research200 - Connectivity Changes in Alzheimer's Disease: July 2021In this shorter episode, Judy covers studies on structural and functional connectivity changes in AD, as well as new methods of integrating multimodal neuroimaging data. All 9 papers were published in July 2021 and focus on improving AD diagnosis using deep learning, specific fMRI measures and more - be sure to check it out! Sections in this episode: fMRI (2:11) Default Mode Network (8:16) Other (10:10) -------------------------------------------------------------- You can find the numbered bibliography for this episode by clicking here, or the link below:https://drive.google.com/file/d...2021-09-1416 min
AMiNDR: A Month in Neurodegenerative Disease Research199 - Treatments targeting neuroprotection in Alzheimer's Disease: July 2021Animal and cell models of Alzheimer's Disease are featured in this episode that covers potential therapeutics that target neuroprotection. We have 5 papers that focus broadly on the subject and 10 more that delve into mechanisms of action of these compounds so join Anusha as she highlights July of 2021's publications on the topic! Sections in this episode: Treatments targeting neuroprotection (1.03) Mechanism of treatments targeting neuroprotection (11.14) -------------------------------------------------------------- You can find the numbered bibliography for this episode by clicking here, or the link below:https://drive.g...2021-09-1026 min
AMiNDR: A Month in Neurodegenerative Disease Research198 - Understanding Cognitive & Behavioural Changes in Alzheimer's Disease: July 2021Visual reaction time, japanese orange scent, language, psychosis, and insomnia are just some of the topics you’ll hear about today in this episode. Have we piqued your interest? Today Ellen tells you about the latest papers on the mechanisms of, and treatments for, cognitive and behavioural changes in Alzheimer's Disease. Enjoy the show! Sections in this episode: Sensory processing & function (3:31) Speech (9:16) Learning & memory (11:17) Psychiatric changes (13:50) Sleep (21:20) -------------------------------------------------------------- You can find the numbered bibliography for this episode by clicking here, or the link below:...2021-09-1031 min
AMiNDR: A Month in Neurodegenerative Disease Research197 - Synaptic transmission in Alzheimer's Disease: July 2021Glory's back for another episode with all the latest updates on research about how disruptions in certain mechanisms of synaptic transmission and plasticity contribute to Alzheimer's disease. We'll be featuring 14 papers published in July 2021 that cover all things synaptic in AD, including ion channel function and LTP! Join us for an episode that's sure to stimulate your own synapses! Sections in this episode: Neurotransmitters (3:00) Neuronal excitability/activity (11:29) Structural (17:15) Synaptic Plasticity (23:15) Memory (29:52) -------------------------------------------------------------- You can find the numbered bibliography for this episode...2021-09-0934 min
AMiNDR: A Month in Neurodegenerative Disease Research196 - Changes to Gene Expression in Alzheimer's Disease: July 2021“Omics”, “differential expression” and “biomarker discovery” – Are these phrases you commonly use in your research? Or have you come across them and wondered what they meant in the context of AD? If you're nodding your head at either of those, this episode is just for you. Join Marcia as she brings you the latest research published in July 2021 on ‘RNA, Transcription and translation in AD’! Sections in this episode: Gene expression and transcriptomics (02:26) Proteomics (17:38) -------------------------------------------------------------- You can find the numbered bibliography for this episode by clicking here, or the link below...2021-09-0725 min
AMiNDR: A Month in Neurodegenerative Disease Research195 - Metabolic Changes, Hemodynamics and EEG studies in Alzheimer's Disease: July 2021Curious about oxidative stress, default mode network markers and EEG patterns associated with Alzheimer's disease? Join us for an exciting episode on metabolic changes, hemodynamics and EEG featuring papers published in July 2021! Studies include conventional and newer methods of improving AD diagnosis, such as recording electrical activity from the outer ear using electrovestibulography or tracking brain metabolite changes in real time with functional magnetic resonance spectroscopy. Come hear about the latest research! Sections in this episode: Metabolic Changes (2:08) Hemodynamics (13:05) EEG (17:34) -------------------------------------------------------------- You can find the numbered bibliography for th...2021-09-0722 min
AMiNDR: A Month in Neurodegenerative Disease Research194 - Treatments targeting Neurotransmitter Imbalances: June 2021In this episode, Anusha will guide you through 20 papers that tackle acetylcholine and glutamate imbalances in Alzheimer's Disease. These papers were published in June of 2021 and address topics like inhibiting cholinesterases and NMDA receptors. We hope this information transmits to your neurons! Sections in this episode: Novel Anti-Cholinesterase Drugs (2.39) Existing Anti-Cholinesterase Drugs (16.28) Targeting Glutamate (26.17) -------------------------------------------------------------- To access the folder with all the bibliographies for 2021 so far, follow this link (it will be updated as we publish episodes and process bibliographies), or click the following link below:http...2021-08-1930 min
AMiNDR: A Month in Neurodegenerative Disease Research193 - Clinical Markers of Alzheimer's Disease: June 2021In this episode, Maria will be going over 17 papers published in June 2021 on Clinical Indicators of Alzheimer's diseaes and mild cognitive impairment. Topics covered will include the use of technology to assess cognition, semantic memory, cognitive tests, behavioural tests, oculomotor tests, and language adaptations. If you're interested in new ways of detecting AD, make sure you tune in! Sections in this episode:Technology for AD and MCI (2:08) Semantic Memory(8:11) Test for Aspects of Cognition (11:38) Oculomotor Markers of Cognition (20:50) Language Adaptations (23:03)-------------------------------------------------------------- Click...2021-08-1829 min
AMiNDR: A Month in Neurodegenerative Disease Research192 - Risk Factors for Alzheimer's Disease: June 2021Naila has 23 papers for you today, that will provide you with an overview of epidemiological research published in June 2021. You'll hear about the incidence and prevalence of AD in specific populations, sociodemographic and health conditions that increase the risk of dementia and AD, and about a few potentially neuroprotective factors as well. Enjoy! Sections in this episode: Prevalence, incidence, multiple factors (2:08) Cardiovascular (20:33) Other health conditions (25:30) Protective (40:52) -------------------------------------------------------------- To access the folder with all the bibliographies for 2021 so far, follow this link (it will be updat...2021-08-1748 min
AMiNDR: A Month in Neurodegenerative Disease Research191 - Detection of Amyloid, Tau and new PET targets in Alzheimer's Disease: June 2021Here, we'll be taking a closer look at 14 papers published in June 2021 that rely on Positron emission tomography imaging (or PET) to detect amyloid and tau pathology in the brain, within the context of Alzheimer's disease! If you're interested in learning about tau and amyloid based detection, alternative PET tracers in AD research, or combining PET with different imaging modalities, make sure to tune it. Sections in this episode: Amyloid-beta based detection (1:30)Tau based detection (9:45)Amyloid-beta and tau (15:04)Case studies (16:48)Other PET targets (19:01)...2021-08-1322 min
AMiNDR: A Month in Neurodegenerative Disease Research190 - Brain Connectivity Changes in Alzheimer's Disease: June 2021Interested in brain connectivity changes specific to Alzheimer's disease? Come join us as Judy presents 13 papers featuring fMRI, machine learning and other brain mapping techniques that explore functional connectivity in AD. You're sure to learn something new! Sections in this episode: fMRI (01:32) Machine Learning (12:10) Other (14:36) -------------------------------------------------------------- You can find the numbered bibliography for this episode by clicking here, or the link below:https://drive.google.com/file/d/1qQcxhvhiOUvDSfqcLh4FbI43oFEEelrm/view?usp=sharingTo access the folder with all the bib...2021-08-1320 min
AMiNDR: A Month in Neurodegenerative Disease Research189 - Vascular Contributions to Alzheimer's Disease & Treatments Targeting the Vasculature: June 2021With a shorter epsiode than usual this month, Elyn is back with an update on vascular contributions to Alzheimer disease and potential treatment avenues targeting the vasculature. Tune in for a summary of 8 papers spanning clinical studies that unpack neuroimaging hallmarks of vascular changes in AD, all the way to mechanistic studies focused on understanding blood-brain barrier dysfunction in Alzheimer disease, and a bonus inclusion of a fluid biomarkers paper on the plasma lipidome! Sections in this episode: Clinical Studies – Neuroimaging and Cardiovascular Risk (4:20) Mechanistic Studies – BBB dysfunction and rescue (13:20) Bonus paper on...2021-08-1221 min
AMiNDR: A Month in Neurodegenerative Disease Research188 - APP processing & Amyloid-beta aggregation in Alzheimer's Disease: June 2021Only 14 papers published on APP processing and Amyloid-beta aggregation in the month of June, what’s going on? Well, it is still our pleasure to give you brief summaries on the matter, so if you research Alzheimer’s disease, you do want to tune in for your monthly update on secretase activity, seeding of misfolding, metal ion content of aggregates, and amyloid-beta toxicity. Sections in this episode: APP Processing & Secretases (3.15) Characterizing Aggregate Content (7.00) Amyloid-β Aggregation (10.09) Downstream effects of Amyloid-β (25.16) -------------------------------------------------------------- To access the folder with all the bibli...2021-08-1130 min
AMiNDR: A Month in Neurodegenerative Disease Research187 - Prevention & Intervention Strategies for Alzheimer's Disease: June 2021In this short and sweet episode, Naila covers 12 papers from June 2021 regarding non-pharmacological strategies to prevent or intervene in dementia progression. You'll hear about a few exercise programs, some creative ways to improve quality of life for people with dementia and caregivers, and a range of neuromodulatory (stimulation) techniques. Sections in this episode: Exercise (1:37) Multidomain / Other (7:05) Neuromodulatory Techniques (15:20) -------------------------------------------------------------- You can find the numbered bibliography for this episode by clicking here, or the link below:https://drive.google.com/file/d/1y6rZuX5vL...2021-08-1027 min
AMiNDR: A Month in Neurodegenerative Disease Research186 - Treatments targeting neuronal protection in Alzheimer's Disease: June 2021Join our host Anusha as she takes you through papers published in June of 2021 that target neuroprotection as a potential treatment avenue for Alzheimer's disease. Half these papers use amyloid-beta induced models of Alzheimer's disease so be sure to check it out if neuroprotection is up your alley. Sections in this episode: Treatments targeting neuroprotection in amyloid-beta induced AD models (2.03) Neuroprotection in other AD models (12.51) -------------------------------------------------------------- You can find the numbered bibliography for this episode by clicking here, or the link below:https://drive.google.com/file/d...2021-08-0724 min
AMiNDR: A Month in Neurodegenerative Disease Research185 - Metabolic Changes, Hemodynamics and EEG in Alzheimer's Disease: June 2021In this shorter episode, Judy goes over papers published in June 2021 that focus on diagnostic tools of Alzheimer's disease. Topics include metabolic changes, hemodynamics and EEG biomarkers. Listen in to find out more! Sections in this episode: Metabolic changes in AD (1:20) Hemodynamics (9:30) EEG (13:30) -------------------------------------------------------------- You can find the numbered bibliography for this episode by clicking here, or the link below:https://drive.google.com/file/d/1lzkStThvq02V_tpeuqBDfmZuLlhg6RwQ/view?usp=sharingTo access the folder with all the bibliog...2021-08-0618 min
AMiNDR: A Month in Neurodegenerative Disease Research184 - Synaptic Transmission in Alzheimer's Disease: June 2021Curious about how neuronal hyperactivity and hippocampal synaptic plasticity impairment contribute to Alzheimer's pathology? Join Glory for the latest updates on research about the mechanisms of synaptic transmission and plasticity affected in Alzheimer's disease. This month, June 2021, delivers 17 new papers that will fill you in on all things synaptic in AD! Give it a listen to find out more and stimulate your own synapses! Sections in this episode: Synapse Function and Plasticity (2:17) Neurotransmitter Systems Affected in AD (11:04) Neuronal Hyperactivity and Calcium Signaling (18:45) Spatial Memory (24:30) Animal Models...2021-08-0533 min
AMiNDR: A Month in Neurodegenerative Disease Research183 - Changes to Gene Expression in Alzheimer's Disease: June 2021We know how critical gene expression and its regulation is to cellular homeostasis. In light of that, it is imperative that we discuss the possibility that Alzheimer’s disease could be caused by disturbances in DNA methylation in certain genes and the potential role of methylation in being a biomarker in AD. In today's episode, Marcia brings you the latest research on this topic, summarizing 9 papers from June 2021. Sections in this episode: Transcription and differential gene expression (02:12) Methylation (09:56) Multiomics (13:29) -------------------------------------------------------------- You can find the numbered bibliography for this epi...2021-08-0418 min
AMiNDR: A Month in Neurodegenerative Disease Research182 - Cognitive & Behavioural Changes in Alzheimer's Disease: June 2021Ellen kicks off this series by telling you about the latest research from June 2021 on topics like cognition, memory, reading, gait, speech, depression, sleep, and even more. Learn how these symptoms may manifest in Alzheimer's disease patients, and the underlying mechanisms that contribute to them. If you're interested in behaviour and cognition in humans or in animals, this episode is for you! Sections in this episode: Cognition & Attention (3:32) Memory (9:59) Speech & Communication (16:31) Gait (23:05) Psychiatric Symptoms (26:58) Sleep & Circadian Rhythms (30:32) -------------------------------------------------------------- You can find the numbe...2021-08-0339 min
AMiNDR: A Month in Neurodegenerative Disease Research181 - Clinical Markers of Alzheimer's Disease Part 2: May 2021From standard clinical testing to motor assessments such as gait performance and handwriting ability, Judy will cover 10 papers on various types of markers in Alzheimer's Disease. Tune in for our final May 2021 episode and learn something new about the different techniques used in AD diagnosis! Sections in this episode: Clinical Testing (1:58) Motor Assessments (7:39) Semantic Dementia (11:28) Sleep (14:03) -------------------------------------------------------------- You can find the numbered bibliography for this episode by clicking here, or the link below:https://drive.google.com/file/d/1pKecrNPbkMwJyc_z7Yeo3P0...2021-07-1518 min
AMiNDR: A Month in Neurodegenerative Disease Research180 - Clinical Markers of Alzheimer's Disease Part 1: May 2021In this episode, Maria goes over 22 papers from May 2021 on various cognitive tests for Alzheimer's disease and mild cognitive impairment. Paper topics include tests of general cognition, visual, verbal and auditory tests, dementia subtypes, machine learning, and language and culturally adapted tests. Sections in this episode: General cognition (2:00) Visual, verbal, and auditory testing (13:50) Other dementia subtypes (18:43) Machine learning (25.08)Language and cultural adaptations (29.32)-------------------------------------------------------------- To access the folder with all the bibliographies for 2021 so far, follow this link (it will be updated as we p...2021-07-1433 min
AMiNDR: A Month in Neurodegenerative Disease Research178 - Amyloid-Beta Pathology in Alzheimer's Disease: May 2021In the second part of our episodes on amyloid-beta, we focus on the ways abeta contributes to AD pathology. This ranges from its effects on the hippocampus and memory, to more mechanistic studies on ion homeostasis, lipid membrane integrity, and prion-like seeding, without forgetting our friend tau! Tune in for an episode as eventful as an episode of Game of Thrones where amyloid-beta wages a war on the good people of Westeros…or...wages a war on neurons. Enjoy! Sections in this episode: Amyloid-beta toxicity: (9:05) Iron Dyshomeostasis: (18:13) Prion-Like Seeding & Spread: (24:19) Miscel...2021-07-1038 min
AMiNDR: A Month in Neurodegenerative Disease Research175 - Role of the Immune System & Glial Cells in Alzheimer's Disease: May 2021In this episode, Courtney takes you through the papers from May of 2021 on the Role of Immune systems and glial cells in Alzheimer's disease pathology! We will be discussing papers related to neuroinflammatory pathways in microglia and astrocytes, metabolism, peripheral inflammation and so much more! Tune in for this exciting episode! Sections in this episode: Microglia (02:07) Astrocytes (10:42) TREM2 (13:34) Metabolism (18:08) Periphery (24:53) -------------------------------------------------------------- You can find the numbered bibliography for this episode by clicking here, or the link below:https://drive.google.com/file/d/1...2021-07-0633 min
AMiNDR: A Month in Neurodegenerative Disease Research173 - APP Processing & Amyloid-Beta Aggregation in Alzheimer's Disease: May 2021Hello hello to fellow baptists, tauists and all protein aggregation enthusiasts! Sarah brings you 15 papers from the month of May on Amyloid-beta aggregation! This is the first part of a 2 episode series on understanding the role amyoid-beta plays in Alzheimer’s disease pathology, and you will hear about APP processing and localization, then amyloid-beta generation and aggregation. We will also throw a teaser on Amyloid-beta detection with a focus on plaques, so stay tuned if you need an update far from the screen while enjoying a walk, transiting to work, or going about your house chores.Are yo...2021-07-0339 min
AMiNDR: A Month in Neurodegenerative Disease Research169 - Treatments targeting Neuroprotection and Synaptic Activity in Alzheimer's Disease: May 2021Anusha will guide you through 21 papers in this episode that target synaptic and neuroprotection as therapeutic intervention for Alzheimer's disease. She covers 3 topics including the use of pre-existing synthetic compounds, naturally occuring compounds, and designing and optimizing drugs to improve efficacy. All of these papers were published in May of 2021 so be sure to check it out to offer your neurons protection from ignorance! Sections in this episode: Using Pre-existing Synthetic Compounds (2.21) Using Naturally Occurring Compounds (12.36) Drug Design (26.35) ------------------------------------------------------------- PLEASE FILL OUR SURVEY TO HELP US IMPROVE OUR PODC...2021-06-2935 min
AMiNDR: A Month in Neurodegenerative Disease Research167 - Vascular Contributions to Alzheimer Disease and Treatments Targeting the Vasculature: May 2021Elyn is back with more on all things vasculature! In this episode, she covers 14 papers that span many topics in the field of vascular contributions to Alzheimer disease - all the way from mechanisms linking cardiovascular and metabolic health to the Alzheimer pathology, to clinical studies associating cognitive symptoms with markers of cerebrovascular damage. Tune in to hear a perspective on AD that's outside of the amyloid cascade hypothesis! Sections in this episode:Overlap Between Cardiovascular Disease and AD (3:56)Clinical Studies on Cerebrovascular Pathology (12:20)Microvascular and Blood-Brain Barrier Changes i...2021-06-2534 min
AMiNDR: A Month in Neurodegenerative Disease Research152 - Vascular Contributions to Alzheimer's Disease & Treatments targeting the Vasculature: March 2021Tired of the age-old amyloid cascade hypothesis? So is Elyn! Join her in this episode unpacking papers that showed up on PubMed in March 2021 that add more evidence to the tight intertwinement of vascular and brain health. Topics in this episode range from mechanistic studies in animal models looking at cerebral blood flow and blood-brain barrier integrity, all the way to clinical studies mapping out cerebrovascular damage across the AD continuum. This is a shorter episode, with only 13 papers covered - perfect for a commute to work or a leisurely bike ride! Sections in this ep...2021-05-1728 min
AMiNDR: A Month in Neurodegenerative Disease Research138 - Vascular Contributions to Alzheimer's Disease and Treatments Targeting the Vasculature: February 2021Elyn is back to guide your through all of the connections between blood vessels and Alzheimer disease, from papers published in February 2021. Starting the episode off with how midlife vascular risk factors can influence AD risk, and finishing with treatments for AD that target the vasculature, you're sure to leave this episode appreciating how intertwined heart health and brain health are. Well worth the longer listen for all of the new insight! Sections in this episode: Midlife Vascular Risk Factors for AD (3.16) Associations of Cerebrovascular Pathology with AD Pathology and Clinical Prog...2021-04-1339 min