Shows
AMiNDR: A Month in Neurodegenerative Disease Research243 - Autophagy & Proteostasis in Alzheimer's Disease: October 2021New year, new papers! Join Kate for your monthly update on all things proteostasis and autophagy as they relate to both AD pathology and potential new therapeutic interventions. In today's papers, we'll journey through the endolysosomal system, say "Hi" to some new chaperone families, and even discuss the interplay between AD and other distinct neurodegenerative diseases. Enjoy! Sections in this episode: Autophagy & Proteostasis Pathology (4:42) Targeting Proteostasis/Autophagy Machinery (28:48) -------------------------------------------------------------- You can find the numbered bibliography for this episode by clicking here, or the link below: https://drive.google...2022-01-0634 min
AMiNDR: A Month in Neurodegenerative Disease Research242 - New Variants & Genetic Insights Part 2: October 2021Welcome to our first episode of 2022! Marcia will bring you 13 genetics papers from October 2021. We will talk about all kinds of topics - right from AD-associated loci to polygenetic risk stratification, all of which can contribute to planning effective treatment strategies. Tune in! Sections in this episode: Transcriptomics/Gene Expression Changes (2:33) Genetic Variants (6:16) Genetic Risk (13:14) MicroRNA (20:10) Other Topics (22:52) -------------------------------------------------------------- You can find the numbered bibliography for this episode by clicking here, or the link below: https://drive.google.com/file/d/1ZmtkgGyhe...2022-01-0427 min
AMiNDR: A Month in Neurodegenerative Disease Research241 - New Variants & Genetic Insights Part 1: October 2021Join Marcia for Part 1 of this genetics episode covering a total of 13 papers. In this one, she talks about papers from October 2021, related to transcriptomics, especially genes that are differentially expressed In Alzheimer’s disease, and some studies with vertebrate and invertebrate AD model organisms and risk loci. Tune in to learn more! Sections in this episode: Transcriptomics/Gene expression changes (2:45)Model organisms (17:21) Risk alleles/variants (22:16) Methods (27:09) -------------------------------------------------------------- You can find the numbered bibliography for this episode by clicking here, or the link below:https...2021-12-2430 min
AMiNDR: A Month in Neurodegenerative Disease Research232 - Prevention & Intervention Strategies for Alzheimer's Disease : September 2021This episode is short and sweet, covering 7 papers on cognitive training, exercise and stimulation techniques. Naila will guide you through the latest in animal models and underlying mechanisms for these potential non-pharmacological interventions. Sections in this episode:Cognitive Training (2:06) Exercise (4:23) Stimulation Techniques (11:38)-------------------------------------------------------------- You can find the numbered bibliography for this episode by clicking here, or the link below:https://drive.google.com/file/d/1PjokO3cFgLOjtRyi9yjQlckHRNKMtiEM/view?usp=sharingTo access the folder with all the bibliographies for 2021 so far, follo...2021-12-0417 min
AMiNDR: A Month in Neurodegenerative Disease Research230 - Risk Factors for Alzheimer's Disease Part 2: September 2021Back for part 2, Naila takes you through 15 papers pertaining to health conditions associated with AD and dementia. You'll hear about infections, cardiovascular and metabolic risk factors, and a few miscellaneous diseases. Sections in this episode: Epidemiology / Multiple Factors (1:00) Immune Conditions (8:00) Metabolic and Cardiovascular (15:00) Neurological Comorbidities (24:50) -------------------------------------------------------------- You can find the numbered bibliography for this episode by clicking here, or the link below:https://drive.google.com/file/d/1Pgl18mXwvDG2xZK9fijICMtfEhI7BXUG/view?usp=sharingTo access the folder with all the...2021-11-3031 min
AMiNDR: A Month in Neurodegenerative Disease Research228 - New Variants & Genetic Insights in Alzheimer's Disease: September 2021Join Glory to learn about the newest genetic variants and mechanisms that have been linked to Alzheimer's disease. In this episode, we'll cover protective and pathogenic AD variants in genes, potential genetic biomarkers for AD, and differential gene expression that can be observed in individuals with AD. With 19 papers from September 2021, you'll hear about some genes that will be worth following up on in the near future to advance our understanding of the disease! Sections in this episode: Genetic variants (3:11) Genetic biomarkers (13:58) Differential gene expression and mRNA (18:05) miRNA regulations (22:55) N...2021-11-2537 min
AMiNDR: A Month in Neurodegenerative Disease Research226 - Treatments Targeting Mitochondria & Metabolism in Alzheimer's Disease: September 2021Let’s take a trip with Vee through the latest literature to the mitochondria and learn about oxidative stress, metabolism and related therapeutics in Alzheimer’s disease pathology. A jam packed session from vitamins to energy homeostasis to metal chelators- this episode has it all! We have 10 publications from September 2021, which will surely “power” your interest. Tune in and get ready to charge up on the exciting research! Sections in this episode: Metabolism (4:26) Mitochondria (11:45) Oxidative Stress (19:47) -------------------------------------------------------------- You can find the numbered bibliography for this episode by clicking here...2021-11-1929 min
AMiNDR: A Month in Neurodegenerative Disease Research216 - Familial Mutations, New Variants & More Genetic Insights: August 2021Buckle down and get ready for a lengthy episode on the most recently discovered familial mutations and variants related to Alzheimer's disease. With Glory as your host, we'll take a look at different variants in genes that may make you more or less susceptible to developing AD. A large chunk of the episode will cover single nucleotide polymorphisms that have been found in various populations and correlate with neurodegenerative disease. You’ll also hear about genetic mutations in patients or families that researchers have linked to familial AD. Sections in this episode: SNPs and r...2021-10-2635 min
AMiNDR: A Month in Neurodegenerative Disease Research215 - Treatments Targeting Mitochondria & Metabolism: August 2021Join Marcia as she explores the what’s, how’s, and why’s of all things oxidative stress, mitochondrial dysfunction and metabolism in AD. With this month’s - August 2021- papers, you’ll hear about the latest related cell and animal model studies, AD-adjunct diabetes, and even about potential therapeutics! So sit back and enjoy! Sections in this episode: Metabolism (2.40) Oxidative Stress (11.02) Mitochondrial Dysfunction (22.25) -------------------------------------------------------------- You can find the numbered bibliography for this episode by clicking here, or the link below:https://drive.goog...2021-10-2333 min
AMiNDR: A Month in Neurodegenerative Disease Research211 - Changes to Gene Expression in Alzheimer's Disease: August 2021“Changes to the expression of genes may influence the delicate balance between disease and health”. If you want to learn about how that is relevant to Alzheimer’s disease, you’ve come to the right place! Join Marcia for this short episode, as she discusses how & why gene expression, its epigenetic regulation and integrative studies are important in Alzheimer’s disease! Sections in this episode: Transcriptome (2:35) Multiomics (8:19) Epigenetics (12:03) -------------------------------------------------------------- You can find the numbered bibliography for this episode by clicking here, or the link below:http...2021-10-1417 min
AMiNDR: A Month in Neurodegenerative Disease Research208 - Prevention & Intervention Strategies in Alzheimer's Disease: August 2021In this short and sweet episode, Naila covers 7 new papers on prevention and intervention of Alzheimer's disease. You'll hear about upcoming clinical trials of behavioural and cognitive interventions, a little bit about the mechanisms underlying the therapeutic effects of exercise, and about non-invasive stimulation techniques for treating AD. Sections in this episode: Cognitive / Physical Training (1:57) Neuromodulatory Techniques (9:27) -------------------------------------------------------------- You can find the numbered bibliography for this episode by clicking here, or the link below:https://drive.google.com/file/d/1W9coBE5hJ7I8Np...2021-10-0717 min
AMiNDR: A Month in Neurodegenerative Disease Research206 - Prevention & Intervention Strategies in Alzheimer's Disease: July 2021Today's episode covers 18 papers on prevention and intervention strategies for Alzheimer's disease and dementia. Naila will take you through clinical trials and animal studies on cognitive training programs, complementary therapies, diet, exercise, and neuromodulatory techniques. There's a lot of unique papers in this one, so we hope you enjoy! Sections in this episode: Cognitive Training (2:52) Complementary Therapies (6:08) Diet (15:30) ; Exercise (19:56) Neuromodulatory Techniques (28:51) -------------------------------------------------------------- You can find the numbered bibliography for this episode by clicking here, or the link below:https://drive.google.c...2021-09-2336 min
AMiNDR: A Month in Neurodegenerative Disease Research196 - Changes to Gene Expression in Alzheimer's Disease: July 2021“Omics”, “differential expression” and “biomarker discovery” – Are these phrases you commonly use in your research? Or have you come across them and wondered what they meant in the context of AD? If you're nodding your head at either of those, this episode is just for you. Join Marcia as she brings you the latest research published in July 2021 on ‘RNA, Transcription and translation in AD’! Sections in this episode: Gene expression and transcriptomics (02:26) Proteomics (17:38) -------------------------------------------------------------- You can find the numbered bibliography for this episode by clicking here, or the link below...2021-09-0725 min
AMiNDR: A Month in Neurodegenerative Disease Research183 - Changes to Gene Expression in Alzheimer's Disease: June 2021We know how critical gene expression and its regulation is to cellular homeostasis. In light of that, it is imperative that we discuss the possibility that Alzheimer’s disease could be caused by disturbances in DNA methylation in certain genes and the potential role of methylation in being a biomarker in AD. In today's episode, Marcia brings you the latest research on this topic, summarizing 9 papers from June 2021. Sections in this episode: Transcription and differential gene expression (02:12) Methylation (09:56) Multiomics (13:29) -------------------------------------------------------------- You can find the numbered bibliography for this epi...2021-08-0418 min
AMiNDR: A Month in Neurodegenerative Disease Research163 - Treatments targeting Oxidative Stress & Metabolism in Alzheimer's disease: March 2021If you are interested in oxidative stress in Alzheimer’s disease, mitochondrial dysfunction, or metabolism, come hear about the ways they can be targeted for therapeutic purposes. Maybe you are tired of hearing about cholinesterase inhibitors or anti-amyloid-beta antibodies and want to explore something different. Tune in with Sarah in this last episode for our series on the papers published in March 2021. She covers 17 abstracts that harness the interconnectedness between mechanisms involved in AD pathology to develop new therapeutics and repurpose others (used in diabetes, hypertension, depression,…) Ready. Set. Play! Sections in this episode:T...2021-05-2943 min
AMiNDR: A Month in Neurodegenerative Disease Research157 - Changes to Gene Expression in Alzheimer's Disease: March 2021Transcriptional and translational dysregulation may cause changes in cellular biology and can lead to disease. In this episode, Marcia brings you the latest research in March 2020 that focus on changes in gene & protein expression and epigenetics in the context of Alzheimer’s disease. Some common terms you’ll hear throughout this episode are transcriptomics, methylome, biomarkers, proteomics, AD models, etc. We also touch upon the up-and-coming field of multiomics, so tune in to hear more! Sections in this episode: Gene expression and transcriptomics (2:03) Gene expression of truncated proteins (7:11) Model organisms...2021-05-2234 min
AMiNDR: A Month in Neurodegenerative Disease Research155 - Prevention & Intervention Strategies for Alzheimer's Disease: March 2021We've got a tour de force of prevention and intervention papers for you today, covering vascular function, cognitive function, diet, exercise, neuromodulatory techniques and stem cell therapies. Naila will take you throuh 20 papers to update you on the AD literature from March 2021! --------------------------------------------------------------You can find the bibliography for this episode by clicking here. To access the folder with all the bibliographies for 2021 so far, follow this link (it will be updated as we publish episodes and process bibliographies), or click the following link below:https://drive.google.com/drive/folders/1N1...2021-05-2044 min
AMiNDR: A Month in Neurodegenerative Disease Research149 - Epidemiology of Risk Factors for Alzheimer's Disease, Part 2: March 2021In part 2 of epidemiological studies from March 2021, a particularly loopy, end-of-week Naila will take you through 22 papers on comorbidities and health conditions linked to Alzheimer's disease. We've got some papers on general frailty and comorbidity burden, treatments for other diseases, sleep apnea, cardiovascular risk factors and vision impairment. Sections in this episode:Comorbidities in general (frailty, dermatitis, cancer, head injury,...) (2.00)Focus on sleep apnea (18.30)Focus on cardiovascular risk (21.36)Ophthalmic conditions (30.27) --------------------------------------------------------------You can find the bibliography for this episode by clicking here. To access the folder with...2021-05-1337 min
AMiNDR: A Month in Neurodegenerative Disease Research142 - Treatments targeting Mitochondria, Oxidative Stress & Metabolism in Alzheimer's Disease: February 2021Marcia is back to bring you the latest in Alzheimer's disease treatment development! Join us as we explore the complex relationship between AD and metabolic disorders like diabetes, and some therapies used to co-treat them. Not enough? We also talk about oxidative stress and mitochondrial dysfunction, and (some new!) compounds aimed at mitigating these. Tune in to get your neurons firing! Sections in this episode: 1) Metabolism: 00:58 2) Oxidative stress: 10:15 3) Mitochondria: 21:20 --------------------------------------------------------------To access the folder with all the bibliographies for 2021 so far, follow this link (it will be updated as we...2021-04-1723 min
AMiNDR: A Month in Neurodegenerative Disease Research137 - Amyloid-beta Toxicity in Alzheimer's Disease: February 2021In this short episode packed full of insight, Jacques navigates the realms of amyloid-beta toxicity in AD. Learn about different techniques and models used to investigate amyloid-beta toxicity, how mouse models can provide insight into toxic amyloid-beta species and the relationship of certain amyloid-beta species with clinical presentations. Sections in this episode: Techniques for Investigating Amyloid-beta Toxicity (2:17) Amyloid-beta Toxicity within Different Cell Types and Species (5:53) Mouse models of Alzheimer’s Disease(12:52) Amyloid-beta Toxicity and Humans (17:01) -------------------------------------------------------------- You can find the bibliography for this episode by...2021-04-1226 min
AMiNDR: A Month in Neurodegenerative Disease Research133 - Changes to RNA, Transcription & Translation in Alzheimer's Disease: February 2021Marcia is back to update you on the latest Alzheimer's research. Today's episode is all about RNA, transcription, translation, proteomics, and more, all in the context of AD. Enjoy. Sections in this episode: RNA & Transcription (1:00) Translation & Proteomics ( 12:28) Miscellaneous (16:26) --------------------------------------------------------------You can find the bibliography for this episode by clicking here. To access the folder with all the bibliographies for 2021 so far, follow this link (it will be updated as we publish episodes and process bibliographies), or click the following link below:https...2021-04-0719 min
AMiNDR: A Month in Neurodegenerative Disease Research129 - Understanding APOE and Familial Mutations in Alzheimer's Disease: February 2021In this episode, Courtney takes you through the papers from February 2021 on understanding ApoE in Alzheimer's disease and through a few papers on the familial mutations in Alzheimer's disease. There is a wide range of topics so be sure tune in for this exciting episode! Sections in this episode: Cognitive impairment with APOE (2:30) Brain banks to model and predict AD progression (8:56) Mechanisms of APOE (13:11) Familial mutations (17:42) --------------------------------------------------------------You can find the bibliography for this episode by clicking here! To access the folder with all the...2021-04-0223 min
AMiNDR: A Month in Neurodegenerative Disease Research118 - Treatments targeting Oxidative Stress, Metabolism and Mitochondria in Alzheimer's Disease: January 2021In this episode, Marcia will take you through papers from January 2021 that involve research on targeting mitochondria, metabolism and oxidative stress as effective therapeutic strategies against AD. Tune in to hear about the relation between AD, diet and metabolic diseases like diabetes, the use of nanotechnology and organelle-specific agents to deliver therapy, and more! Sections in this episode: Oxidative Stress (1:00) Metabolism (11:55) Mitochondria (18:45) ------------------------------------------------------------------ To access the folder with the bibliographies for the month of January, follow this link (it will be updated as we publish episodes and proc...2021-03-0822 min
AMiNDR: A Month in Neurodegenerative Disease Research114 - Mechanisms underlying Risk Factors for Alzheimer's Disease, Part 2: January 2021In Part 2 of mechanisms underlying AD risk factors, you'll learn about comorbidities ranging from traumatic brain injury to schizophrenia, hear a little bit about hearing loss, and be exposed to some research on exposure to toxic metals. Naila is your host for today, and will take you through 13 papers from January 2021! Sections in this episode: Comorbidities (2.10) Noise/Hearing Loss (12.02) Toxic Metal Exposure (16.59) Neuroprotective Factors (24.49) ------------------------------------------------------------------ Click here to see the list of papers covered in this episode. To access the folder with the biblio...2021-03-0330 min
AMiNDR: A Month in Neurodegenerative Disease Research112 - Changes to RNA, Transcription & Translation in Alzheimer's Disease: January 2021In today’s episode, Marcia brings you the latest research from Jan 2021 on changes to RNA, Transcription and Translation in the context of Alzheimer’s disease. We also talk about some really in-fashion techniques like multi-omics, deconvolution, mendelian randomization and co-localization. Tune in to learn about these techniques and more! Sections in this episode: Multiomics (2 papers) 1:10 Mendelian randomization and colocalization (3) 3:45 Gene pathway and network analysis (2) 7:21 Differential gene expression/deconvolution (2) 9:41 Methylation (2) 12:35 Post translational modifications (2) 15:19 microRNAs (3) 17:38 Miscellaneous (2) 22:53 ------------------------------------------------------------------ Click here to see...2021-03-0126 min
AMiNDR: A Month in Neurodegenerative Disease ResearchNovel Drugs Targeting Amyloid-Beta: Alzheimer's Disease June 2020Having trouble keeping up with the literature in Alzheimer's Disease? We are here to help! Ellen tells you about papers on drugs in development targeting amyloid-beta production, aggregation, and toxicity from June 2020! If you're interested in hearing more about treatments for AD, you should also check out our episodes on pre-clinical and clinical testing. To receive the list of papers covered (with timestamps), please fill this form: --------> https://forms.gle/CVVbznAFM8pamdgk6 ------- or by tweeting at us: @AMiNDR_podcast -----------------------------------------------------------------------List of sections in this episode: ...2020-09-0941 min
AMiNDR: A Month in Neurodegenerative Disease ResearchClinical Testing: Alzheimer's Disease June 2020Having trouble keeping up with the literature in Alzheimer's Disease? We are here to help! In this episode, Joseph presents papers published in June 2020 where pharmacological approaches and new compounds are tested on humans. You will hear about intranasal insulin, probiotics, Diclofenac, Crenezumab, and more. If you are interested in this topic, you can also check our episodes on pre-clinical testing, which encompass studies done on animals. We are also working on an episode focused on repurposing and refining existing drugs, coming out soon. Enjoy! To receive the list of papers covered (with time...2020-09-0117 min
AMiNDR: A Month in Neurodegenerative Disease ResearchGenetic Landscape Part 2: Alzheimer's Disease June 2020Having trouble keeping up with the literature in Alzheimer's Disease? We are here to help! This episode is the second of two parts on the genetic landscape of AD! Here, Marcia will tell you about papers published this past June on sex differences, DNA methylation, some on transcriptomic, and more. Enjoy! To receive the list of papers covered (with timestamps), please fill this form: -------> https://forms.gle/CVVbznAFM8pamdgk6 ------- or by tweeting at us: @AMiNDR_podcast -------------------------------------------------------------------- List...2020-08-3133 min
AMiNDR: A Month in Neurodegenerative Disease ResearchGenetic Landscape Part 1: Alzheimer's Disease June 2020Having trouble keeping up with the literature in Alzheimer's Disease? We are here to help! This episode is the first of two parts on the genetic landscape of AD! Here, Marcia will tell you about papers published this past June on the well-known AD-related genes PSEN-1 and APOE, as well as amyloid-beta related mutations, novel variants, and other variants/mutations. Enjoy! To receive the list of papers covered (with timestamps), please fill this form: -------> https://forms.gle/CVVbznAFM8pamdgk6 ------- or by tweeting at us: @AMiNDR_podcas...2020-08-2830 min