Shows
AMiNDR: A Month in Neurodegenerative Disease Research142 - Treatments targeting Mitochondria, Oxidative Stress & Metabolism in Alzheimer's Disease: February 2021Marcia is back to bring you the latest in Alzheimer's disease treatment development! Join us as we explore the complex relationship between AD and metabolic disorders like diabetes, and some therapies used to co-treat them. Not enough? We also talk about oxidative stress and mitochondrial dysfunction, and (some new!) compounds aimed at mitigating these. Tune in to get your neurons firing! Sections in this episode: 1) Metabolism: 00:58 2) Oxidative stress: 10:15 3) Mitochondria: 21:20 --------------------------------------------------------------To access the folder with all the bibliographies for 2021 so far, follow this link (it will be updated as we...2021-04-1723 min
AMiNDR: A Month in Neurodegenerative Disease Research140 - Treatments targeting the Immune System, Glia, Autophagy & Proteostasis: February 2021Deciding what to do during your lunch break or out on a stroll? Well, look no further! Listen in on Abdullah covering the latest papers from February 2021 covering the treatments targeting glia, immune cells, proteostasis and autophagy. Tune in to learn about out of the box ideas that may hold therapeutic benefits for Alzheimer's Disease. Sections in this episode: Targeting the Immune System & Glial Cells (3:43) Targeting Proteostasis & Autophagy (20:15) -------------------------------------------------------------- To access the folder with all the bibliographies for 2021 so far, follow this link (it will be updated as we...2021-04-1428 min
AMiNDR: A Month in Neurodegenerative Disease Research128 - Treatments targeting Neuroprotection, Synaptic Activity, and Neurotransmitter Balance in Alzheimer's Disease: February 2021To kick of the February 2021 series, Anusha guides you through papers recently published that target synaptic health and acetylcholinesterase activity to uncover pathological mechanisms that underlie Alzheimer's disease. If you like thinking about thinking, look no further than this episode! Sections in this episode: Synaptic Plasticity and Preservation (2:05) Oxidative Stress (8:52) Miscellaneous (12:37) Acetylcholinesterase Inhibitor Rivastigmine (17:47) Novel Inhibitors (21:36) --------------------------------------------------------------You can find the bibliography for this episode by clicking here! To access the folder with the bibliographies for the month of Ja...2021-04-0133 min
AMiNDR: A Month in Neurodegenerative Disease Research124 - Treatments targeting Neurotransmitter Balance in Alzheimer's Disease: January 2021Anusha is your guide through 14 papers which target neurotransmitter balance. These papers were all published in January 2021 and focus mostly on targeting acetylcholinesterase activity with a sprinkling of other targets such as NMDA receptors. If you love synapses and are dying to find out how we can get them working properly again in AD, make sure to give this episode a listen! Sections in this episode: Targeting Acetylcholinesterase Activity (2:25) Other targets (18:33) --------------------------------------------------------------You can find the bibliography for today's episode here. To access the folder with t...2021-03-1424 min
AMiNDR: A Month in Neurodegenerative Disease Research119 - Brain Imaging of Structural Changes in Alzheimer's Disease: January 2021Learn about the studies from January 2021 that used imaging to investigate structural changes in Alzheimer's disease. This includes imaging of different brain regions, as well as other structures like the retina. By better understanding these changes, we can learn more about the disease's pathology and mechanisms, which could lead us to the ability to better treat this disease, or detect it at earlier stages. Sections in this episode: Deep Learning (01:22) Specific Brain Regions (18:54) Eyes (22:09) Misc. (25:52) ------------------------------------------------------------------ You can find the bibliography for this episode by clicking here. 2021-03-0930 min
AMiNDR: A Month in Neurodegenerative Disease Research118 - Treatments targeting Oxidative Stress, Metabolism and Mitochondria in Alzheimer's Disease: January 2021In this episode, Marcia will take you through papers from January 2021 that involve research on targeting mitochondria, metabolism and oxidative stress as effective therapeutic strategies against AD. Tune in to hear about the relation between AD, diet and metabolic diseases like diabetes, the use of nanotechnology and organelle-specific agents to deliver therapy, and more! Sections in this episode: Oxidative Stress (1:00) Metabolism (11:55) Mitochondria (18:45) ------------------------------------------------------------------ To access the folder with the bibliographies for the month of January, follow this link (it will be updated as we publish episodes and proc...2021-03-0822 min
AMiNDR: A Month in Neurodegenerative Disease Research106 - Treatments targeting neuronal & synaptic protection in Alzheimer's Disease: January 2021In the first episode of our January 2021 series, Anusha will be guiding you through papers that traverse topics within neuroprotection in AD models, including therapies that target A-beta toxicity, glutamate excito-toxicity, and novel therapeutic approaches. We hope you get excited - within reason! Sections in this episode: Amyloid-beta toxicity and glutamate excito-toxicity (2:03) Novel therapeutic strategies (9:30) ------------------------------------------------------------------ Access the list of papers covered in this episode here.To access the folder with the bibliographies for the month of January, follow this link (it will be updated as we...2021-02-2218 min
AMiNDR: A Month in Neurodegenerative Disease Research94 - Brain Imaging of Structural Changes & Connectivity in Alzheimer's Disease, Part 1: September 2020Bhumika updates you on the latest papers on brain imaging of structural changes and connectivity in AD! This includes MRI and PET imaging to characterize or diagnosis this disease, as well as new machine learning technology, and more! Enjoy, and look out for part 2 soon! ------------------------------------------------------------------ To receive the list of papers covered, please fill this form: --------> https://forms.gle/CVVbznAFM8pamdgk6 ------- or by tweeting at us: @AMiNDR_podcast ------------------------------------------------------------------ We would appreciate your feedback so we can better cater to your needs. You can f...2021-01-1524 min
AMiNDR: A Month in Neurodegenerative Disease Research79- Treatments Targeting Oxidative Stress, Metabolism, & Behaviour in Alzheimer's Disease: September 2020If you can’t quite decide which episode to listen to, maybe give this one a try. We’re covering preclinical models of AD as it pertains to mitochondria, autophagy, metabolism, behaviour, and much much more. Join Anusha so she doesn’t have to explore all these exciting papers all by herself! List of Sections:Mitochondria: 1.31Autophagy/Metabolism: 5.34Behaviour: 12.12Other: 23.07------------------------------------------------------------------ To receive the list of papers covered, please fill this form: --------> https://forms.gle/CVVbznAFM8pamdgk6 ------- or by tweetin...2020-12-1835 min
AMiNDR: A Month in Neurodegenerative Disease Research69 - Treatments Targeting Synaptic Transmission in Alzheimer's Disease: September 2020Are you invested in the role of neurotransmission in Alzheimer’s disease? Well then buckle in because in this episode, Anusha will go over the latest and greatest compounds that target disease state changes to synaptic transmission in animal and in vitro models of Alzheimer’s.This episode covers the papers published in September of 2020 that use animal models and tissue culture to test the effects of novel compounds for their effects in rescuing synaptic transmission changes in AD. We’ll have 8 papers on cholinergic system, 3 on the glutamatergic neurotransmission, and 1 on G-protein coupled receptors. Ma...2020-11-3024 min
AMiNDR: A Month in Neurodegenerative Disease Research65 - GWAS, Transcriptomics, & New Tools for Genetic Research: Alzheimer’s Disease August 2020Naila is back to round off our risk factors section with an episode on genome-wide association studies, transcriptomic research, combining genetics and neuroimaging data, and new tools to make all this work easier. Tune in to learn more about the techniques used to study the genetic underpinnings of AD, and perhaps to learn some long gene names to impress people at the next party you attend - especially if you can still remember them by then. ------------------------------------------------------------------ To receive the list of papers covered, please fill this form: --------> https://forms.gle/CVVbznAFM8pamd...2020-11-2533 min
AMiNDR: A Month in Neurodegenerative Disease Research61 - More on Biomarkers: Alzheimer's Disease August 2020Naila covers a wide variety of biomarkers and topics from papers published in August 2020 on Alzheimer's disease: identifying biomarkers of cognition and memory in cognitively unimpaired older adults, biomarkers that can help predict AD progression and differentiation, new biomarker assays and tools for improved diagnosis, EEG, metabolic profiling... ------------------------------------------------------------------ To receive the list of papers covered, please fill this form: --------> https://forms.gle/CVVbznAFM8pamdgk6 ------- or by tweeting at us: @AMiNDR_podcast ------------------------------------------------------------------ We would appreciate your feedback so we can better cater to your needs. ...2020-11-2032 min
AMiNDR: A Month in Neurodegenerative Disease Research54 - CSF Biomarkers: Alzheimer's Disease August 2020In this episode, Alex covers the latest research involving CSF biomarkers as a critical diagnostic tool in Alzheimer’s Disease identification and treatment. You’ll hear about some of the more typical clinical CSF biomarkers seen in AD, as well as the signature CSF AD biomarker profile, and you’ll also learn about how some of these CSF biomarkers relate to the different stages of AD progression and severity. ------------------------------------------------------------------ To receive the list of papers covered, please fill this form: --------> https://forms.gle/CVVbznAFM8pamdgk6 ------- or by tweeting at us: @AMiND...2020-11-1620 min
AMiNDR: A Month in Neurodegenerative Disease Research33 - More on Biomarkers in Alzheimer's Disease June 2020Having trouble keeping up with the literature in Alzheimer's Disease? We are here to help! In this episode, Sarah covers a wide array of papers on biomarkers in AD! You may have listened to our other episodes on this topic (blood and CSF biomarkers). This one gathers the papers that did not fit in those categories, and you're in for a treat: TDP-43, C-reactive protein, epoxide hydrolase, cholinesterase activity, lipids, and more!Enjoy.------------------------------------------------------------------ To receive the list of papers covered (with timestamps), please fill this form: --------> https://forms...2020-10-1838 min
AMiNDR: A Month in Neurodegenerative Disease ResearchMetabolism, Mitochondrial (Dys)function, Oxidative Stress, Autophagy, & Gut Microbiome: Alzheimer's Disease June 2020Having trouble keeping up with the literature in Alzheimer's Disease? We are here to help!In this episode, Anusha combines different topics pertaining to disease mechanisms in Alzheimer's Disease, starting with metabolic changes, then zooming in on mitochondria, and oxidative stress. Last, she covers the publications on autophagy and the gut microbiome, and how their involvement in Alzheimer's pathology. These papers were all published in June 2020. We hope you find this podcast enjoyable, accessible and useful for your work! To receive the list of papers covered (with timestamps), please fill this form: ...2020-08-2035 min