Shows
AMiNDR: A Month in Neurodegenerative Disease Research341 - Prevention & Intervention Strategies for ADNaila brings you 21 articles from January 2024, on non-pharmacological approaches to the prevention and intervention of Alzheimer's disease. You'll be treated to research from computational modeling, to rodent models, to clinical trials, with a particular focus on optimizing and personalizing intervention strategies. This episode also covers some research on the role of caregivers, and several papers consider the socioeconomic and ethnographic context in which these studies take place. Let's get to it! Stimulation Techniques (7)Exercise (3)Cognitive Training (2) Art Therapy and Dyad Interventions (4)Lifestyle Interventions and Prevention (5)...2024-04-0946 min
AMiNDR: A Month in Neurodegenerative Disease Research340 - Structure Neuroimaging in Alzheimer's Disease using AIJoin Christy for 12 papers from January 2024 on structural neuroimaging in the diagnosis of Alzheimer's disease. This episode is a bit different from past ones because it's all about the use of machine learning and deep learning. Whether you're an AI researcher or simply curious about the topic, you won't want to miss this episode. Detecting AD (3:42) Predictions, associations or comparisons (16:48)-------------------------------------------------------------- You can find the bibliography for this episode here, or by clicking the link below:https://drive.google.com/file/d/1KE4oVzsdER5iTuSqN9J5UMUk27S5w...2024-04-0231 min
AMiNDR: A Month in Neurodegenerative Disease Research339 - Treatments Targeting Neuroprotection in Alzheimer's DiseaseAnother series of AMiNDR kicks off with this episode. Anusha takes you through 7 papers published in January 2024 targeting neuroprotection in AD. If you'd like to hear about potential compounds that could reduce neurodegeneration in Alzheimer's disease, this is the episode for you.Testing for neuroprotection in cell lines (2:57)Testing for neuroprotection using in vivo AD models (11:47)-------------------------------------------------------------- You can find the bibliography for this episode here, or by clicking the link below:https://drive.google.com/file/d/1A4HZVCtgh5AwZkd5V2ATZSFAxGJt48q3/view?usp=drive_linkT...2024-03-2619 min
AMiNDR: A Month in Neurodegenerative Disease Research338 - Interview with Joseph Liang - Navigating The Journey To (And Through) Graduate SchoolAnother special episode to help kick off our return! In what we hope to be a recurring special series, an interview with members in our scholarly community on navigating the multiple facets of life as a scientist. In the first episode, host Kevin Nishimura interviews one of our own Joseph Liang on his personal journey to and through graduate school. Tune in to learn what he has to say about getting into graduate school, and how his perspective on the journey has changed since he's started! We hope you enjoy, and please let us know if you want to...2024-02-2024 min
AMiNDR: A Month in Neurodegenerative Disease Research337 - Prevention & Intervention Strategies for ADIn today's episode, Naila provides an overview of 14 articles published in November 2023 on non-pharmacological interventions for AD. You'll hear about cognitive training, music therapy, chair yoga, providing support to caregivers, and a range of neural stimulation techniques. Enjoy! Cognitive and Social Factors (2:26)Lifestyle interventions (13:40)Stimulation Techniques (19:20)-------------------------------------------------------------- You can find the bibliography for this episode here, or by clicking the link below:https://drive.google.com/file/d/1A4HZVCtgh5AwZkd5V2ATZSFAxGJt48q3/view?usp=drive_linkTo access the folder with AL...2024-02-1429 min
AMiNDR: A Month in Neurodegenerative Disease Research336 - Treatments Targeting Cholinergic Neurotransmission in ADJoin us as we cover a set of papers published in November 2023 on treatments targeting cholinergic transmission in Alzheimer's disease. In this episode hosted by Christy, we will go over various topics, from drug discovery using synthesized compounds to drug testing of plant extracts, as well as improving drug delivery through the blood-brain barrier. Enjoy! Papers evaluating synthesized compounds (2:00) Papers targeting AchE (10:45)-------------------------------------------------------------- You can find the bibliography for this episode here, or by clicking the link below:https://drive.google.com/file/d/1wh1EFtB3KrW0J6C...2024-02-0629 min
AMiNDR: A Month in Neurodegenerative Disease Research335 - A Conversation with Gina Martin: Bringing Visual Awareness to DementiaAs we get back up to speed on our regular episodes, we thought we'd treat you (and ourselves) to something out of the ordinary: a conversation on how visual storytelling can shape how we think - and feel - about Alzheimer's disease. Host Naila Kuhlmann had the pleasure of interviewing Gina Martin, who founded the Bob and Diane Fund to support and promote visual storytelling about Alzheimer's and dementia. Tune in to get the backstory on the fund, an auditory glimpse at the work of this year's winner, a discussion on the social narrative of Alzheimer's disease, and reflections...2024-01-2952 min
AMiNDR: A Month in Neurodegenerative Disease Research334 -Treatments Targeting Neuroprotection in Alzheimer's DiseaseHello listeners, it’s been a while since we last released an episode but we are back with another series here at AMiNDR bringing you a synopsis of publications on Alzheimer’s disease (AD) research on various topics that were released in November of 2023. In this episode, Anusha takes you through 11 papers testing potential neuroprotective agents for AD treatment. You’ll hear about naturally and pharmaceutically-derived compounds as well as strategies that exploit cell-endogenous processes for neuroprotection in AD. Testing Naturally-Derived Compounds for Neuroprotective effects (3:53)Testing Cell-Endogenous Mechanisms for Neuroprotection (16:57)Testing Pharmac...2024-01-2327 min
AMiNDR: A Month in Neurodegenerative Disease Research333 - Cognitive & Behavioural Changes in Alzheimer's Disease: February 2023If you’re interested in hearing about the impact of hearing aids on quality of life in AD patients, or how having a stable life partner can slow down the progression of dementia, tune in to this episode on the latest in cognitive and behavioural research in Alzheimer's disease! Judy will cover 9 papers on sleep, depressive symptoms and sensory processing, all published in February 2023. This is one you don't want to miss! Sections in this episode: Sleep (2:42) Depressive Symptoms (8:05) Sensory Processing (12:59) -------------------------------------------------------------- You can find the bibliography for this...2023-05-0819 min
AMiNDR: A Month in Neurodegenerative Disease Research332 - Prevention & Intervention Strategies for Alzheimer's Disease: February 2023In today's episode, Naila provides you with an overview of 10 paper published in February 2023, on non-pharmacological therapies for Alzheimer's disease. You'll learn about a virtual reality intervention targeting anxiety, the signaling pathways underlying the potential benefits of acupuncture, the challenges of implementing new interventions, and what spectral light flicker means. Happy listening! Sections in this episode: Psychological Interventions (1:37) Physical Activity (7:26) Neuromodulatory Techniques (14:05) -------------------------------------------------------------- You can find the bibliography for this episode here, or by clicking the link below:https://drive.google.com/file/d/1ZG-uORwCnfP383EN7-a2...2023-05-0327 min
AMiNDR: A Month in Neurodegenerative Disease Research331 - Treatments Targeting Neuroprotection in Alzheimer's Disease: February 2023This short and sweet episode kicks off the February 2023 series, highlighting studies all the way from worms to humans. Anusha will take you through 9 papers that converge on targeting neuroprotection in Alzheimer's disease. If you're interested in learning about implicated pathways or potential therapeutics, this episode is sure to whet your appetite. Sections in this episode: Targeting Specific Neuroprotective Pathways (3:39) Targeting Neuroprotection Broadly (13.21) -------------------------------------------------------------- You can find the bibliography for this episode here, or by clicking the link below:https://drive.google.com/file/d/1n7wQss1hiT-F...2023-05-0223 min
AMiNDR: A Month in Neurodegenerative Disease Research321 - Prevention & Intervention Strategies for Alzheimer's Disease: November 2022For today's episode, Naila is back to take you through 20 papers on prevention and intervention strategies in Alzheimer's. You'll be treated to the latest on mindfulness and meditation, the default mode network's involvement in Alzheimer's, strategies for assessing and optimizing therapies, stimulation techniques and more. Enjoy! Sections in this episode: Innovation assessment (3:08) Cognitive Training (6:36) Mindfulness and Movement (13:39) Diet (26:00) Sensory Stimulation (30:24) Neuromodulatory Techniques (39:45) -------------------------------------------------------------- To find the numbered bibliography with all the papers covered in this episode, click here, or use the link belo...2023-02-2848 min
AMiNDR: A Month in Neurodegenerative Disease Research320 - Treatments Targeting Neuroprotection in Alzheimer's Disease: November 2022In this episode, Anusha guides you through 11 papers that were published in November of 2022. These papers study the efficacy of treatments targeting neuroprotection in Alzheimer's Disease models. Tune in if you want to be on the cutting edge of drug discovery and development in the field of AD. Sections in this episode: Drug Discovery and Development of Novel Therapeutics (3:49) Testing Existing Compounds (17:27) -------------------------------------------------------------- To find the numbered bibliography with all the papers covered in this episode, click here, or use the link below:https://drive.google.com/file...2023-02-2325 min
AMiNDR: A Month in Neurodegenerative Disease Research316 - Treatments Targeting Neuroprotection in Alzheimer's Disease: October 2022Anusha brings you another episode of AMiNDR featuring literature published in October 2022. In this episode, you'll hear 12 papers that converge on the topic of treatments that target neurotoxicity. This episode is poised to leave you feeling hopeful about the various treatment avenues to be pursued so be sure to tune in! Sections in this episode: Targeting Neurotoxicity in vitro (3:53) Invertebrate models of AD (8:41) Transgenic AD models (14:48) Other AD models (22:47) -------------------------------------------------------------- To find the numbered bibliography with all the papers covered in this episode, click here, or use...2023-01-2431 min
AMiNDR: A Month in Neurodegenerative Disease Research307 - Cognitive & Behavioural Changes in Alzheimer's Disease Part 2: July 2022In Part 2 of Cognitive and Behavioural Changes, Naila covers 8 papers on neuropsychiatric, social and cognitive symptoms linked to Alzheimer's disease, and their implications for diagnosis and disease management. You'll learn about the links between AD and depression, the importance of social networks, and machine learning methods for identifying important lifestyle information from clinical notes. Enjoy! Neuropsychiatric Changes (2:11)Cognitive Changes (10:25)Statistics and Machine Learning (17:05)-------------------------------------------------------------- To find the numbered bibliography with all the papers covered in this episode, click here, or use the link below:https://dr...2022-11-0423 min
AMiNDR: A Month in Neurodegenerative Disease Research300 - Prevention and Intervention Strategies for Alzheimer's Disease: June 2022Today's episode includes 15 papers on non-pharmacological treatments and complementary therapies for AD. Naila will take you through research published in June 2022 on an array of topics including olfactory training, beer, choir participation, light therapy, and transcranial magnetic stimulation. You'll be treated to research on both the human and animal level, with a special focus on targeting neuroinflammation and brain connectivity! Sections in this episode: Cognitive Training and Complementary Therapies (2:44) Diet and Exercise (15:38) Light Therapy (21:57) Electrical and Magnetic Stimulation (29:46) -------------------------------------------------------------- To find the numbered bibliography with all the...2022-09-1741 min
AMiNDR: A Month in Neurodegenerative Disease Research299 - Cognitive Assessment in Alzheimer's Disease Part 2: June 2022We promised you we would be back with more on clinical assessment for Alzheimer’s disease, and here we are to deliver. Stick around to hear about papers published in June 2022 on validating variations of the Montreal Cognitive Assessment, tracking Activities of Daily living, and digital tools for assessing cognition. Our harvest yielded 7 abstracts, all presented in this episode! Sections in this episode: Combinign Multiple Neurocognitive Domains (7.00) Activities of Daily Living (14.00) Digital Tools & Automation (18.30) -------------------------------------------------------------- To find the numbered bibliography with all the papers covered in this e...2022-09-1529 min
AMiNDR: A Month in Neurodegenerative Disease Research297 - Genetic Insights for Alzheimer's Disease: June 2022In this episode, Joseph covers papers published in June 2022 on GWAS studies, transcriptomics, genetic and genomic studies and the like on Alzheimer’s disease. Stay tuned! Sections in this episode: Genetic & Disease Overlaps (2:15) RNA & Transcriptomics (5:10) Genetic Testing (10:25) GWAS Studies (15:24) Specific Genes (21:04) Extra (28:55) -------------------------------------------------------------- To find the numbered bibliography with all the papers covered in this episode, click here, or use the link below:https://drive.google.com/file/d/1diNBktrzfDyUcmjSUiItcdRUNbxEAcNl/view?usp=sharingTo access the folder with ALL ou...2022-09-0632 min
AMiNDR: A Month in Neurodegenerative Disease Research296 - Treatments Targeting Neuroprotection in Alzheimer's Disease: June 2022Anusha brings you 12 papers today on the development of treatments that target neuroprotection in Alzheimer's disease. This includes a range of research models, from in silico and drug discovery studies, to rodent models of AD. Enjoy! Sections in this episode: In Silico and Drug Discovery Studies (2:27) Testing Phytochemicals in AD Rodent Models (7:29) -------------------------------------------------------------- To find the numbered bibliography with all the papers covered in this episode, click here, or use the link below:https://drive.google.com/file/d/1e7YNEtMDqWevplwM1K3nCHXzWE21a7zX/view?usp=shari...2022-09-0125 min
AMiNDR: A Month in Neurodegenerative Disease Research295 - Cognitive and Behavioural Changes in Alzheimer's Disease: June 2022This episode contains a whole range of topics in cognitive and behavioural changes in AD! Tune in as Judy covers a variety of papers published in June 2022, spanning from from sensory processing in mouse models to antidepressants in human patients. There's bound to be something that piques your interest! Sections in this episode: Studies Using Mouse Models (2:03) Sensory Processing (7:15) Behavioural Changes in AD (13:08) Cognitive Changes in AD (15:49) Neuropsychiatric Changes in AD (19:45) -------------------------------------------------------------- To find the numbered bibliography with all the papers covered in this epi...2022-08-2924 min
AMiNDR: A Month in Neurodegenerative Disease Research292 - Synaptic Transmission in Alzheimer's Disease: June 2022We are kicking off our June 2022 series of episodes with this short and sweet episode. Anusha takes a look at papers published on the subject of changes to synaptic transmission and neuronal excitability in Alzheimer’s disease. If you're interested in bridging the gap between changes to neuronal function and behavioural consequences, this episode is a great place to start! Sections in this episode: Changes to neurotransmission and neuronal excitability (2.44) Changes to movement/learning and memory (11.06) -------------------------------------------------------------- To find the numbered bibliography with all the papers covered in this episode...2022-08-2317 min
AMiNDR: A Month in Neurodegenerative Disease Research283 - Cognitive Assessment in Alzheimer's Disease Part 1: March 2022This is our monthly update on clinical assessment of Alzheimer’s disease, based on abstracts published in March 2022! This is the first of a 2-part series on the matter, where we bring together ways to assess cognitive function by looking at one neurocognitive domain, such as learning and memory, language, perceptual-motor skills, and even by looking at activities of daily living. This is perfect for you if you are researching cognition, or are interested in Neurology or Geriatrics in general! Sections in this episode: Learning & Memory (6:40) Language (14:48) Perceptual-Motor (20:43) Attention (23:44) Oth...2022-05-2831 min
AMiNDR: A Month in Neurodegenerative Disease Research282 - Treatments Targeting Neuroprotection in Alzheimer's Disease: March 2022Another 12 papers published in March of 2022 awaits you. This episode is all about treatments that target neuroprotection to treat AD. The papers model it by inducing cytotoxicity in the brain, either with molecules like amyloid beta or genetic mutations. Anusha is excited to guide you through promising treatment options, are you excited too? Sections in this episode: Stem Cell-Based Therapy (3.01) Testing compounds in A-Beta AD Models (4.52) Testing compounds in APP/PS1 AD Model (14.49) Test compounds in other AD Models (17.15) -------------------------------------------------------------- To find the numbered bibliography with al...2022-05-2622 min
AMiNDR: A Month in Neurodegenerative Disease Research281 - Synaptic Transmission in Alzheimer's Disease: March 2022Ease in to our March 2022 series with 8 papers published on the subject of synaptic transmission in Alzheimer's Disease. Anusha will highlight changes to connectivity and ones caused by APP and Tau proteins so check out this episode to bridge the communication gap in your brain too! Sections in this episode: Synaptic Connectivity Changes (1.44) APP/Tau contribution to Synaptic Dysfunction (7.47) -------------------------------------------------------------- To find the numbered bibliography with all the papers covered in this episode, click here, or use the link below:https://drive.google.com/file/d/1BY9b9lZ7...2022-05-2418 min
AMiNDR: A Month in Neurodegenerative Disease Research278 - Risk Factors for Alzheimer's Disease Part 1: February 2022In today's episode, Naila will guide you through 19 papers from February 2022 on the prevalence and incidence of Alzheimer's disease in various study populations, social determinants of health, as well as environmental and lifestyle factors that may influence the risk of dementia. Part 2 will be available as a bibliography, which you can find in our show notes or at www.amindr.com! Sections in this episode: Epidemiological Studies (1:56) Racial/Ethnic Disparities (11:50) Social Determinants (25:24) Lifestyle and Environmental Factors (31:44) -------------------------------------------------------------- To find the numbered bibliography with all the papers...2022-04-2642 min
AMiNDR: A Month in Neurodegenerative Disease Research275 - Prevention and Intervention Strategies for Alzheimer's Disease: February 2022This month's episode covers a range of interventions and non-pharmacological treatments that could help prevent or live with AD. Naila will take you through the various mechanisms underlying the impact of different lifestyle interventions, the potential therapeutic effects of exercise, what mushroom consumption and ketogenic diets might have to offer, and plenty of other stimulating topics! Sections in this episode: Cognitive and Multidomain Interventions (1:35) Diet (7:42) Exercise (12:00) Neuromodulatory Techniques (26:20) -------------------------------------------------------------- To find the numbered bibliography with all the papers covered in this episode, click here, or use the...2022-04-2043 min
AMiNDR: A Month in Neurodegenerative Disease Research273 - Risk Factors for Alzheimer's Disease Part 2: January 2022In Part 2 of epidemiological studies published in January 2022, we'll focus on the association between cardiovascular health, diabetes and Alzheimer's disease. Naila will guide you through the latest research on how things like blood pressure, body mass index and insulin resistance are related to dementia and to AD pathology. Sections in this episode: Cardiovascular Factors (2:35) BMI (12:25) Diabetes and Related Conditions (14:49) -------------------------------------------------------------- To find the numbered bibliography with all the papers covered in this episode, click here, or use the link below:https://drive.google.com/file/d/1pES...2022-04-0528 min
AMiNDR: A Month in Neurodegenerative Disease Research272 - Risk Factors for Alzheimer's Disease Part 1: January 2022In Part 1 of this 2-part episode on epidemiological studies published in January 2022, Naila will take you through 12 papers on risk and protective factors linked to Alzheimer's disease, ranging from stressful life events, to exposure to greenspace in one's neighborhood, to sleep troubles and testosterone. We cover a lot of ground in this episode, and if you want to cover even more, look out for Part 2 coming soon! Sections in this episode: Sociodemographic and Lifestyle Factors (2:11) Miscellaneous Health Factors (15:01) -------------------------------------------------------------- To find the numbered bibliography with all the papers covered in th...2022-03-3128 min
AMiNDR: A Month in Neurodegenerative Disease Research268 - Prevention and Intervention Strategies for Alzheimer's Disease: January 2022Today's episode will take you all the way from the molecular to the human level in 16 papers on non-pharmacological approaches for preventing or treating Alzheimer's disease. Naila will guide you through the latest research on exercise in AD mouse models, nutritional supplements that could decrease the risk of AD, the potential therapeutic effects of repetitive transcranial magnetic stimulation, and more! Sections in this episode: Interventions Targeting Cognition (1.50) Multidomain Interventions (7.36) Nutrition (13.30) Exercise (19.06) Stimulatory Techniques (25.23) -------------------------------------------------------------- To find the numbered bibliography with all the papers covered...2022-03-2239 min
AMiNDR: A Month in Neurodegenerative Disease Research266 - Risk Factors for Alzheimer's Disease: December 2021Discover the latest on risk and protective factors of AD, from the perspective of 18 observational studies published in December 2021. Naila will take you through socioeconomic factors, nutrition, exercise, and various comorbidities related to AD. Sections in this episode: Prevalence and Socioeconomic Factors (1:45) Nutrition (13:11) Health-Related Factors (18:49) -------------------------------------------------------------- To find the numbered bibliography with all the papers covered in this episode, click here, or use the link below:https://drive.google.com/file/d/15gMFkpU55HqCYCSQMYvaVgVngdY9j8DT/view?usp=sharingTo access the folder with a...2022-03-0836 min
AMiNDR: A Month in Neurodegenerative Disease Research262 - Prevention and Intervention Strategies for Alzheimer's Disease: December 2021In today's episode, Naila will take you through 11 studies from December 2021 on different non-pharmacological methods for treating Alzheimer's disease. You'll hear the latest research on the importance of sleep, how cognitive training might reduce Alzheimer's pathology, and numerous stimulation techniques for improving cognitive function in people with AD. Enjoy! Sections in this episode: Cognition and Sleep (1.34) Exercise (6.28) Neuromodulatory Techniques (12.16)-------------------------------------------------------------- To find the numbered bibliography with all the papers covered in this episode, click here, or use the link below:https://drive.google.com/file/d/1EK...2022-02-2227 min
AMiNDR: A Month in Neurodegenerative Disease Research258 - Cognitive & Behavioural Changes in Alzheimer's Disease: December 2021To kick off this series, Ellen tells you about 17 studies published in December 2021 on how different forms of cognition, sensory processing, and psychiatric health can be affected in Alzheimer's disease, as well as papers exploring new treatment options! If you are an Alzheimer's researcher, or are just interested in hearing about the latest progress in this field, you don't want to miss this episode! Sections in this episode: Sensory Function & Processing (3:38) Emotional Processing (9:24) Language (11:15) Future Thinking (13:21) Preclinical Testing in AD Models (14:38) Comparing Different Diseases (21:09) Clinic...2022-02-1535 min
AMiNDR: A Month in Neurodegenerative Disease Research257 - Risk Factors for Alzheimer's Disease: November 2021Naila's back with 19 epidemiological and observational studies published in November 2021. It's quite the panoply of topics - you'll hear about marital status, air pollution, metabolic syndrome, medication use and more. We hope you enjoy! Sections in this episode: Epidemiological and Environmental (1.44) Vaccine/Medication Use (15.10) Psychomotor (22.48) Metabolic Comorbidities (26.18) Other Comorbidities (31.11) -------------------------------------------------------------- To find the numbered bibliography with all the papers covered in this episode, click here, or use the link below:https://drive.google.com/file/d/1Sv1PUzE2PV2lppDwY2-lPMTReLWaPux5/view?usp...2022-02-1039 min
AMiNDR: A Month in Neurodegenerative Disease Research255 - Treatments Targeting Neuroprotection and Neurotransmission in Alzheimer's Disease: November 202117 papers have "Targeting neurotransmission and synaptic dysfunction in AD" written all over it. Figuratively speaking of course. Anusha covers topics like targeting neurotoxicity and calcium flux, or acetylcholine transmission and balance, or even targeting monoamine oxidases to improve AD-like pathology. Better yet, this episode lets you keep up to date as all the papers were published in November of 2021. Sections in this episode: Targeting synaptic dysfunction (2.34) Targeting M1 acetylcholine receptors (14.03) Targeting cholinesterases by modifying existing drugs (17.32) Targeting cholinesterases with novel drugs (22.49) Targeting monoamine oxidases (27.31) -------------------------------------------------------------- To...2022-02-0432 min
AMiNDR: A Month in Neurodegenerative Disease Research254 - Tau Protein Pathology in Alzheimer's Disease: November 2021Join Kate for a comprehensive summary of everything tau from papers published in November 2021. We'll talk post-translational modifications, prion-like seeding pathology, molecular modeling, and even touch on a potential AD therapies targeting this fascinating little microtubule helper. Enjoy! :) Sections in this episode: Tau Aggregation and Post-Translational Modifications (03:03) Tau Seeding and General Tau Pathology (12:49) Novel Therapeutics (22:58) -------------------------------------------------------------- To find the numbered bibliography with all the papers covered in this episode, click here, or use the link below:https://drive.google.com/file/d/1bN5cizXqwbfTb-zaQsSckYjMcyz75kzF/view?us...2022-02-0330 min
AMiNDR: A Month in Neurodegenerative Disease Research253 - Vascular Contributions to Alzheimer's Disease: November 2021Interested in a fresh perspective on the etiology of AD? Join Elyn for her monthly tour through the new research on vascular contributions to Alzheimer disease! Whether this is your niche field, or you want to look at the disease through a new lens, this episode is perfect for you. Tune in to hear about endothelial cell biology, a phase 2 clinical trial, and several animal models! Sections in this episode: Endothelial Cell Biology & Amyloid Clearance (4:40) Insights from Animal Models (8:44) Insights from Human Studies (13:49) -------------------------------------------------------------- To find the number...2022-01-3123 min
AMiNDR: A Month in Neurodegenerative Disease Research252 - Clinical Assessment of Alzheimer's Disease: November 2021Welcome all researchers, students, and clinicians who are interested in learning about clinical testing for Alzheimer’s disease! This episode is dedicated to papers published back in November 2021 on new and old assessment methods to help in the diagnosis of Alzheimer’s. This includes testing cognitive processes and performance on activities of daily living, detecting Alzheimer’s, and distinguishing it from other dementias. You will hear about some new cognitive and non-cognitive parameters to consider as well, so tune in for your monthly fill of news in the field! Sections in this episode: Existing cognitive tests (7...2022-01-2937 min
AMiNDR: A Month in Neurodegenerative Disease Research251 - Prevention & Interventions for Alzheimer's Disease: November 2021In today's episode, Naila will guide you through 10 papers that were published in November 2021 on preventing and treating Alzheimer's disease. You'll hear about snoring, caffeine consumption, the mechanisms underlying exercise, and a bunch of neuromodulatory techniques that could treat certain aspects of AD. Hopefully you'll find this latest research to be stimulating! Sections in this episode: Modifiable Risk Factors (2:02) Neuromodulatory Techniques (8:55) -------------------------------------------------------------- To find the numbered bibliography with all the papers covered in this episode, click here, or use the link below:https://drive.google.com/file/d/1oP...2022-01-2725 min
AMiNDR: A Month in Neurodegenerative Disease Research250 - Changes to Synaptic Transmission in Alzheimer's Disease: November 2021You have just entered the magical world of Alzheimer’s literature. You are about to experience 8 papers that do their best to better understand the changes in synaptic transmission in Alzheimer’s disease. Where did we find such curious abstracts you ask? It just so happens that these were all papers published in November of 2021. Ready to go? Close your eyes and let Anusha be your guide through this journey of curiosity. Sections in this episode: Synaptic Changes in AD Mouse Models (2.27) AD-related changes to Lipid Regulation (11.25) -------------------------------------------------------------- To find the...2022-01-2517 min
AMiNDR: A Month in Neurodegenerative Disease Research249 - Cognitive & Behavioural Changes in Alzheimer's Disease: November 2021To kick off the November 2021 series, Ellen brings you 11 papers published this past November on the topic of Alzheimer's disease and dementia. Tune in to hear about research on chronic stress, sleep quality, and an active compound from the cannabis plant that could be used to treat AD symptoms! That's just a taste of what you'll hear about in this episode that covers a diverse array of research all about cognition and behavioural symptoms in AD. Sections in this episode: Mild Behavioural Impairment (3:31) Perception (5:35) Stress & Psychiatric Disturbances (7:28) Sleep (15:47) Pote...2022-01-2127 min
AMiNDR: A Month in Neurodegenerative Disease Research247 - Risk Factors for Alzheimer's Disease Part 2: October 2021Naila is back for part 2, to take you through epidemiological studies on lifestyle factors and comorbidities related to Alzheimer's disease. In today's episode, you'll learn about dietary factors, the association between hair loss and AD, and even a little about Covid-19 (sorry!). Lots to learn in just 13 papers! Sections in this episode: Lifestyle factors (1:39) Nutrition (7:08) Physical and Psychiatric Comorbities (13:30) -------------------------------------------------------------- You can find the numbered bibliography for this episode by clicking here, or the link below: https://drive.google.com/file/d/1PTf3HweI53JJNntYHZlSRjfcJFuOcLJW/view?us...2022-01-1427 min
AMiNDR: A Month in Neurodegenerative Disease Research246 - Risk Factors for Alzheimer's Disease Part 1: October 2021In Part 1 of our episode on epidemiological studies from October 2021, Naila will cover 11 papers on demographic and socioeconomic factors related to dementia and Alzheimer's disease. You'll hear a lot on subjective cognitive decline, education and occupation. Enjoy, and be sure to check out Part 2! Sections in this episode: Prevalence and Demographics (1:33) Education (7:51) Socioeconomic status and occupation (14:13) Other (23:38) -------------------------------------------------------------- You can find the numbered bibliography for this episode by clicking here, or the link below: https://drive.google.com/file/d/1PTf3HweI53JJNntYHZlSRjfcJFuOcLJW/view?usp...2022-01-1226 min
AMiNDR: A Month in Neurodegenerative Disease Research239 - Prevention & Intervention Strategies for Alzheimer's Disease: October 2021We've got a short and sweet episode for you today, with 7 papers from October 2021 on the intervention and prevention of AD. Tune in to hear Naila ramble on about pet therapy, update you on diet and exercise research in animal models, and provide a stimulating overview of neuromodulatory techniques. Sections in this episode: Complimentary Therapies (2:55) Lifestyle Interventions (9:30) Stimulation Techniques (13:28) -------------------------------------------------------------- You can find the numbered bibliography for this episode by clicking here, or the link below:https://drive.google.com/file/d/1C7WBstTEh5Fhfr_bsOdjX...2021-12-2020 min
AMiNDR: A Month in Neurodegenerative Disease Research236 - Detecting Amyloid, Tau & New Markers in the Brain: October 2021To kick off our series on papers published in October 2021, we'll look at 7 papers that rely on Positron Emission Tomography (or PET) imaging to detect amyloid and tau pathology in the brain, within the context of Alzheimer's disease! If you're interested in learning about tau and amyloid based detection, alternative PET tracers in AD research, or combining PET with different imaging modalities, make sure to tune into this episode. Sections in this episode: Amyloid Detection (2:35) Tau Detection (7:40) Amyloid + Tau (10:41) Miscellaneous (12:34) -------------------------------------------------------------- To access the folder with al...2021-12-1315 min
AMiNDR: A Month in Neurodegenerative Disease Research232 - Prevention & Intervention Strategies for Alzheimer's Disease : September 2021This episode is short and sweet, covering 7 papers on cognitive training, exercise and stimulation techniques. Naila will guide you through the latest in animal models and underlying mechanisms for these potential non-pharmacological interventions. Sections in this episode:Cognitive Training (2:06) Exercise (4:23) Stimulation Techniques (11:38)-------------------------------------------------------------- You can find the numbered bibliography for this episode by clicking here, or the link below:https://drive.google.com/file/d/1PjokO3cFgLOjtRyi9yjQlckHRNKMtiEM/view?usp=sharingTo access the folder with all the bibliographies for 2021 so far, follo...2021-12-0417 min
AMiNDR: A Month in Neurodegenerative Disease Research230 - Risk Factors for Alzheimer's Disease Part 2: September 2021Back for part 2, Naila takes you through 15 papers pertaining to health conditions associated with AD and dementia. You'll hear about infections, cardiovascular and metabolic risk factors, and a few miscellaneous diseases. Sections in this episode: Epidemiology / Multiple Factors (1:00) Immune Conditions (8:00) Metabolic and Cardiovascular (15:00) Neurological Comorbidities (24:50) -------------------------------------------------------------- You can find the numbered bibliography for this episode by clicking here, or the link below:https://drive.google.com/file/d/1Pgl18mXwvDG2xZK9fijICMtfEhI7BXUG/view?usp=sharingTo access the folder with all the...2021-11-3031 min
AMiNDR: A Month in Neurodegenerative Disease Research229 - Risk Factors for Alzheimer's Disease Part 1: September 2021In today's episode, Naila takes you through 10 papers on risk factors associated with Mild Cognitive Impairment, Alzheimer's and dementia. You'll hear a little on lifestyle factors, air and noise pollutants, and hormones. Stay tuned for Part 2! Sections in this episode: Lifestyle & Environmental Factors (2:09) Hormones (15:13) -------------------------------------------------------------- You can find the numbered bibliography for this episode by clicking here, or the link below:https://drive.google.com/file/d/1BUfTeMbAC0HzYcXRieJSQdsoNKS9r2J7/view?usp=sharingTo access the folder with all the bibliographies for 2021 so far, follo...2021-11-2721 min
AMiNDR: A Month in Neurodegenerative Disease Research227 - Autophagy & Proteostasis in Alzheimer's Disease: September 2021Tune into this month's episode on the latest research on autophagy and proteostasis in Alzheimer's Disease. This includes papers on how autophagy and protein homeostasis are dysfunctional in this disease, and potential treatments that target these cellular pathways. Enjoy! Sections in this episode: Proteostatic and autophagic dysregulation (4:33) RNA splicing, binding, and signaling (10:32) Glycans, glycoproteins, and fatty acids (19:29) Amyloid precursor protein (24:16) Targeting Proteostasis/Autophagy Machinery (26:55) -------------------------------------------------------------- You can find the numbered bibliography for this episode by clicking here, or the link below:https...2021-11-2332 min
AMiNDR: A Month in Neurodegenerative Disease Research225 - Detecting Amyloid, Tau and New Markers in the Brain in Alzheimer's Disease: September 2021Let's take a closer look at 18 papers published in September 2021 that rely on positron emission tomography (or PET) to detect amyloid and tau pathology in the brain, within the context of Alzheimer's disease! If you're interested in learning about tau and amyloid based detection, alternative PET tracers in AD research, or combining PET with different imaging modalities, make sure to tune into this episode. Sections in this episode: Amyloid-based detection (2.35) Tau-based detection (9.35) Amyloid & Tau (21.30) Other targets (24.25) -------------------------------------------------------------- You can find the numbered bibliography for this episode...2021-11-1829 min
AMiNDR: A Month in Neurodegenerative Disease Research223 - Treatments Targeting Neurotransmission in Alzheimer's Disease: September 202118 papers published in September of 2021 await you. What do they all have in common? They explore treatments for Alzheimer's disease that all target neurotransmission. If you're interested in restoring acetylcholine balance or other treatments that also improve cognitive function in Alzheimer's disease, tune in to hear Anusha take you through the literature. Sections in this episode: Discovery and synthesis of novel cholinesterase inhibitors (3.17) Tacrine-based cholinesterase inhibitors (11.26) Modifying existing treatments (16.16) Multi-target treatments (23.00) -------------------------------------------------------------- You can find the numbered bibliography for this episode by clicking here, or the lin...2021-11-1227 min
AMiNDR: A Month in Neurodegenerative Disease Research214 - Risk Factors for Alzheimer's Disease: August 2021Make yourself comfortable, because we cover a lot of ground in today's episode. Naila will guide you through 24 papers from August 2021, all pertaining to epidemiological studies on the risk and protective factors related to AD. You'll hear about some basic epidemiology, environmental and socioeconomic risk factors, lifestyle factors, and health conditions related to AD. Sections in this episode: Epidemiology & Social Factors (1.52) Diet (16.53) Sleep (24.19) Comorbidities (28.00) -------------------------------------------------------------- You can find the numbered bibliography for this episode by clicking here, or the link below:https://drive.google...2021-10-2147 min
AMiNDR: A Month in Neurodegenerative Disease Research209 - Treatments targeting Neurotransmission in Alzheimer's Disease: August 2021This is an episode that explores the creation and testing of drugs that aim to restore neurotransmitter balance in Alzheimer's disease. It covers 14 papers that were all published in August of 2021, and Anusha will guide you through papers on targets including cholinesterases, serotonin, and glutamate receptors. Hit that play button if you'd like to hear more. Sections in this episode: Targeting acetylcholine with novel compounds (2.29) Other targets with novel compounds (13.23) Testing for or improving upon existing ACE inhibitors (17.28) -------------------------------------------------------------- You can find the numbered bibliog...2021-10-0924 min
AMiNDR: A Month in Neurodegenerative Disease Research208 - Prevention & Intervention Strategies in Alzheimer's Disease: August 2021In this short and sweet episode, Naila covers 7 new papers on prevention and intervention of Alzheimer's disease. You'll hear about upcoming clinical trials of behavioural and cognitive interventions, a little bit about the mechanisms underlying the therapeutic effects of exercise, and about non-invasive stimulation techniques for treating AD. Sections in this episode: Cognitive / Physical Training (1:57) Neuromodulatory Techniques (9:27) -------------------------------------------------------------- You can find the numbered bibliography for this episode by clicking here, or the link below:https://drive.google.com/file/d/1W9coBE5hJ7I8Np...2021-10-0717 min
AMiNDR: A Month in Neurodegenerative Disease Research207 - Treatments targeting neuroprotection & synaptic activity in Alzheimer's Disease: August 2021Another month passed means another month of literature for AMiNDR to bring to you! This time, Anusha will be highlighting papers from August of 2021 that are about treatments targeting neuroprotection and synaptic activity in Alzheimer's disease. Beginning with computation and cuvettes and ending with clinical trials, we have 15 papers for your perusal so check out this episode if this topic tickles your fancy. Sections in this episode: Drug discovery and testing in vitro (2.26) Testing potential compounds in AD models (7.06) Phase II Clinical Trials (21.42) -------------------------------------------------------------- You can...2021-10-0526 min
AMiNDR: A Month in Neurodegenerative Disease Research206 - Prevention & Intervention Strategies in Alzheimer's Disease: July 2021Today's episode covers 18 papers on prevention and intervention strategies for Alzheimer's disease and dementia. Naila will take you through clinical trials and animal studies on cognitive training programs, complementary therapies, diet, exercise, and neuromodulatory techniques. There's a lot of unique papers in this one, so we hope you enjoy! Sections in this episode: Cognitive Training (2:52) Complementary Therapies (6:08) Diet (15:30) ; Exercise (19:56) Neuromodulatory Techniques (28:51) -------------------------------------------------------------- You can find the numbered bibliography for this episode by clicking here, or the link below:https://drive.google.c...2021-09-2336 min
AMiNDR: A Month in Neurodegenerative Disease Research205 - Treatments targeting neurotransmission in Alzheimer's Disease: July 2021Journey through the entire spectrum of drug development as Anusha guides you through 19 papers that were published in July of 2021. We span research that begins with drug discovery all the way to the end goal: Phase II clinical trials. If you're interested in targeting levels of acetylcholine and monoamines, you're really going to like this episode! Sections in this episode: Synthesis and Discovery of Cholinesterase Inhibitors (2.47) Drug Interactions with Multiple targets (9.29) Pre-clinical Trials (18.23) Clinical Trials (25.39) -------------------------------------------------------------- You can find the numbered bibliography for this...2021-09-2230 min
AMiNDR: A Month in Neurodegenerative Disease Research204 - Clinical Markers of Alzheimer's Disease Part 2: July 2021In this episode, Ellen tells you about 9 papers that have developed new ways to screen for dementia. Some of these are old, tried-and-true cognitive screening tools that are given a new twist, others are brand new technology that bring cognitive testing to the modern age. You’re sure to find something you enjoy in this episode if you do neurodegenerative disease research, or even if you don’t! Sections in this episode: Technology-based tools (3:44) Adapting tests to other languages (8:34) Other new tools for testing cognition (12:22) -------------------------------------------------------------- You ca...2021-09-2121 min
AMiNDR: A Month in Neurodegenerative Disease Research203 - Clinical Markers of Alzheimer's Disease Part 1: July 2021In the first part of this 2-parter episode, Ellen covers studies that compare and contrast different cognitive tests, or analysis techniques, for diagnosing AD at early stages, or predicting the conversion of pre-dementia stages to Alzheimer’s Disease. There are also some studies that compare cognitive abilities between different types of dementia. You'll hear about memory, spatial awareness, social cognition, and more! Sections in this episode: Cognitive decline & memory (3:32) Semantic fluency (16:42) Social cognition (18:21) Spatial awareness (21:47) -------------------------------------------------------------- You can find the numbered bibliography for this e...2021-09-1725 min
AMiNDR: A Month in Neurodegenerative Disease Research200 - Connectivity Changes in Alzheimer's Disease: July 2021In this shorter episode, Judy covers studies on structural and functional connectivity changes in AD, as well as new methods of integrating multimodal neuroimaging data. All 9 papers were published in July 2021 and focus on improving AD diagnosis using deep learning, specific fMRI measures and more - be sure to check it out! Sections in this episode: fMRI (2:11) Default Mode Network (8:16) Other (10:10) -------------------------------------------------------------- You can find the numbered bibliography for this episode by clicking here, or the link below:https://drive.google.com/file/d...2021-09-1416 min
AMiNDR: A Month in Neurodegenerative Disease Research199 - Treatments targeting neuroprotection in Alzheimer's Disease: July 2021Animal and cell models of Alzheimer's Disease are featured in this episode that covers potential therapeutics that target neuroprotection. We have 5 papers that focus broadly on the subject and 10 more that delve into mechanisms of action of these compounds so join Anusha as she highlights July of 2021's publications on the topic! Sections in this episode: Treatments targeting neuroprotection (1.03) Mechanism of treatments targeting neuroprotection (11.14) -------------------------------------------------------------- You can find the numbered bibliography for this episode by clicking here, or the link below:https://drive.g...2021-09-1026 min
AMiNDR: A Month in Neurodegenerative Disease Research198 - Understanding Cognitive & Behavioural Changes in Alzheimer's Disease: July 2021Visual reaction time, japanese orange scent, language, psychosis, and insomnia are just some of the topics you’ll hear about today in this episode. Have we piqued your interest? Today Ellen tells you about the latest papers on the mechanisms of, and treatments for, cognitive and behavioural changes in Alzheimer's Disease. Enjoy the show! Sections in this episode: Sensory processing & function (3:31) Speech (9:16) Learning & memory (11:17) Psychiatric changes (13:50) Sleep (21:20) -------------------------------------------------------------- You can find the numbered bibliography for this episode by clicking here, or the link below:...2021-09-1031 min
AMiNDR: A Month in Neurodegenerative Disease Research196 - Changes to Gene Expression in Alzheimer's Disease: July 2021“Omics”, “differential expression” and “biomarker discovery” – Are these phrases you commonly use in your research? Or have you come across them and wondered what they meant in the context of AD? If you're nodding your head at either of those, this episode is just for you. Join Marcia as she brings you the latest research published in July 2021 on ‘RNA, Transcription and translation in AD’! Sections in this episode: Gene expression and transcriptomics (02:26) Proteomics (17:38) -------------------------------------------------------------- You can find the numbered bibliography for this episode by clicking here, or the link below...2021-09-0725 min
AMiNDR: A Month in Neurodegenerative Disease Research195 - Metabolic Changes, Hemodynamics and EEG studies in Alzheimer's Disease: July 2021Curious about oxidative stress, default mode network markers and EEG patterns associated with Alzheimer's disease? Join us for an exciting episode on metabolic changes, hemodynamics and EEG featuring papers published in July 2021! Studies include conventional and newer methods of improving AD diagnosis, such as recording electrical activity from the outer ear using electrovestibulography or tracking brain metabolite changes in real time with functional magnetic resonance spectroscopy. Come hear about the latest research! Sections in this episode: Metabolic Changes (2:08) Hemodynamics (13:05) EEG (17:34) -------------------------------------------------------------- You can find the numbered bibliography for th...2021-09-0722 min
AMiNDR: A Month in Neurodegenerative Disease Research194 - Treatments targeting Neurotransmitter Imbalances: June 2021In this episode, Anusha will guide you through 20 papers that tackle acetylcholine and glutamate imbalances in Alzheimer's Disease. These papers were published in June of 2021 and address topics like inhibiting cholinesterases and NMDA receptors. We hope this information transmits to your neurons! Sections in this episode: Novel Anti-Cholinesterase Drugs (2.39) Existing Anti-Cholinesterase Drugs (16.28) Targeting Glutamate (26.17) -------------------------------------------------------------- To access the folder with all the bibliographies for 2021 so far, follow this link (it will be updated as we publish episodes and process bibliographies), or click the following link below:http...2021-08-1930 min
AMiNDR: A Month in Neurodegenerative Disease Research193 - Clinical Markers of Alzheimer's Disease: June 2021In this episode, Maria will be going over 17 papers published in June 2021 on Clinical Indicators of Alzheimer's diseaes and mild cognitive impairment. Topics covered will include the use of technology to assess cognition, semantic memory, cognitive tests, behavioural tests, oculomotor tests, and language adaptations. If you're interested in new ways of detecting AD, make sure you tune in! Sections in this episode:Technology for AD and MCI (2:08) Semantic Memory(8:11) Test for Aspects of Cognition (11:38) Oculomotor Markers of Cognition (20:50) Language Adaptations (23:03)-------------------------------------------------------------- Click...2021-08-1829 min
AMiNDR: A Month in Neurodegenerative Disease Research192 - Risk Factors for Alzheimer's Disease: June 2021Naila has 23 papers for you today, that will provide you with an overview of epidemiological research published in June 2021. You'll hear about the incidence and prevalence of AD in specific populations, sociodemographic and health conditions that increase the risk of dementia and AD, and about a few potentially neuroprotective factors as well. Enjoy! Sections in this episode: Prevalence, incidence, multiple factors (2:08) Cardiovascular (20:33) Other health conditions (25:30) Protective (40:52) -------------------------------------------------------------- To access the folder with all the bibliographies for 2021 so far, follow this link (it will be updat...2021-08-1748 min
AMiNDR: A Month in Neurodegenerative Disease Research191 - Detection of Amyloid, Tau and new PET targets in Alzheimer's Disease: June 2021Here, we'll be taking a closer look at 14 papers published in June 2021 that rely on Positron emission tomography imaging (or PET) to detect amyloid and tau pathology in the brain, within the context of Alzheimer's disease! If you're interested in learning about tau and amyloid based detection, alternative PET tracers in AD research, or combining PET with different imaging modalities, make sure to tune it. Sections in this episode: Amyloid-beta based detection (1:30)Tau based detection (9:45)Amyloid-beta and tau (15:04)Case studies (16:48)Other PET targets (19:01)...2021-08-1322 min
AMiNDR: A Month in Neurodegenerative Disease Research190 - Brain Connectivity Changes in Alzheimer's Disease: June 2021Interested in brain connectivity changes specific to Alzheimer's disease? Come join us as Judy presents 13 papers featuring fMRI, machine learning and other brain mapping techniques that explore functional connectivity in AD. You're sure to learn something new! Sections in this episode: fMRI (01:32) Machine Learning (12:10) Other (14:36) -------------------------------------------------------------- You can find the numbered bibliography for this episode by clicking here, or the link below:https://drive.google.com/file/d/1qQcxhvhiOUvDSfqcLh4FbI43oFEEelrm/view?usp=sharingTo access the folder with all the bib...2021-08-1320 min
AMiNDR: A Month in Neurodegenerative Disease Research189 - Vascular Contributions to Alzheimer's Disease & Treatments Targeting the Vasculature: June 2021With a shorter epsiode than usual this month, Elyn is back with an update on vascular contributions to Alzheimer disease and potential treatment avenues targeting the vasculature. Tune in for a summary of 8 papers spanning clinical studies that unpack neuroimaging hallmarks of vascular changes in AD, all the way to mechanistic studies focused on understanding blood-brain barrier dysfunction in Alzheimer disease, and a bonus inclusion of a fluid biomarkers paper on the plasma lipidome! Sections in this episode: Clinical Studies – Neuroimaging and Cardiovascular Risk (4:20) Mechanistic Studies – BBB dysfunction and rescue (13:20) Bonus paper on...2021-08-1221 min
AMiNDR: A Month in Neurodegenerative Disease Research188 - APP processing & Amyloid-beta aggregation in Alzheimer's Disease: June 2021Only 14 papers published on APP processing and Amyloid-beta aggregation in the month of June, what’s going on? Well, it is still our pleasure to give you brief summaries on the matter, so if you research Alzheimer’s disease, you do want to tune in for your monthly update on secretase activity, seeding of misfolding, metal ion content of aggregates, and amyloid-beta toxicity. Sections in this episode: APP Processing & Secretases (3.15) Characterizing Aggregate Content (7.00) Amyloid-β Aggregation (10.09) Downstream effects of Amyloid-β (25.16) -------------------------------------------------------------- To access the folder with all the bibli...2021-08-1130 min
AMiNDR: A Month in Neurodegenerative Disease Research187 - Prevention & Intervention Strategies for Alzheimer's Disease: June 2021In this short and sweet episode, Naila covers 12 papers from June 2021 regarding non-pharmacological strategies to prevent or intervene in dementia progression. You'll hear about a few exercise programs, some creative ways to improve quality of life for people with dementia and caregivers, and a range of neuromodulatory (stimulation) techniques. Sections in this episode: Exercise (1:37) Multidomain / Other (7:05) Neuromodulatory Techniques (15:20) -------------------------------------------------------------- You can find the numbered bibliography for this episode by clicking here, or the link below:https://drive.google.com/file/d/1y6rZuX5vL...2021-08-1027 min
AMiNDR: A Month in Neurodegenerative Disease Research186 - Treatments targeting neuronal protection in Alzheimer's Disease: June 2021Join our host Anusha as she takes you through papers published in June of 2021 that target neuroprotection as a potential treatment avenue for Alzheimer's disease. Half these papers use amyloid-beta induced models of Alzheimer's disease so be sure to check it out if neuroprotection is up your alley. Sections in this episode: Treatments targeting neuroprotection in amyloid-beta induced AD models (2.03) Neuroprotection in other AD models (12.51) -------------------------------------------------------------- You can find the numbered bibliography for this episode by clicking here, or the link below:https://drive.google.com/file/d...2021-08-0724 min
AMiNDR: A Month in Neurodegenerative Disease Research185 - Metabolic Changes, Hemodynamics and EEG in Alzheimer's Disease: June 2021In this shorter episode, Judy goes over papers published in June 2021 that focus on diagnostic tools of Alzheimer's disease. Topics include metabolic changes, hemodynamics and EEG biomarkers. Listen in to find out more! Sections in this episode: Metabolic changes in AD (1:20) Hemodynamics (9:30) EEG (13:30) -------------------------------------------------------------- You can find the numbered bibliography for this episode by clicking here, or the link below:https://drive.google.com/file/d/1lzkStThvq02V_tpeuqBDfmZuLlhg6RwQ/view?usp=sharingTo access the folder with all the bibliog...2021-08-0618 min
AMiNDR: A Month in Neurodegenerative Disease Research184 - Synaptic Transmission in Alzheimer's Disease: June 2021Curious about how neuronal hyperactivity and hippocampal synaptic plasticity impairment contribute to Alzheimer's pathology? Join Glory for the latest updates on research about the mechanisms of synaptic transmission and plasticity affected in Alzheimer's disease. This month, June 2021, delivers 17 new papers that will fill you in on all things synaptic in AD! Give it a listen to find out more and stimulate your own synapses! Sections in this episode: Synapse Function and Plasticity (2:17) Neurotransmitter Systems Affected in AD (11:04) Neuronal Hyperactivity and Calcium Signaling (18:45) Spatial Memory (24:30) Animal Models...2021-08-0533 min
AMiNDR: A Month in Neurodegenerative Disease Research183 - Changes to Gene Expression in Alzheimer's Disease: June 2021We know how critical gene expression and its regulation is to cellular homeostasis. In light of that, it is imperative that we discuss the possibility that Alzheimer’s disease could be caused by disturbances in DNA methylation in certain genes and the potential role of methylation in being a biomarker in AD. In today's episode, Marcia brings you the latest research on this topic, summarizing 9 papers from June 2021. Sections in this episode: Transcription and differential gene expression (02:12) Methylation (09:56) Multiomics (13:29) -------------------------------------------------------------- You can find the numbered bibliography for this epi...2021-08-0418 min
AMiNDR: A Month in Neurodegenerative Disease Research182 - Cognitive & Behavioural Changes in Alzheimer's Disease: June 2021Ellen kicks off this series by telling you about the latest research from June 2021 on topics like cognition, memory, reading, gait, speech, depression, sleep, and even more. Learn how these symptoms may manifest in Alzheimer's disease patients, and the underlying mechanisms that contribute to them. If you're interested in behaviour and cognition in humans or in animals, this episode is for you! Sections in this episode: Cognition & Attention (3:32) Memory (9:59) Speech & Communication (16:31) Gait (23:05) Psychiatric Symptoms (26:58) Sleep & Circadian Rhythms (30:32) -------------------------------------------------------------- You can find the numbe...2021-08-0339 min
AMiNDR: A Month in Neurodegenerative Disease Research181 - Clinical Markers of Alzheimer's Disease Part 2: May 2021From standard clinical testing to motor assessments such as gait performance and handwriting ability, Judy will cover 10 papers on various types of markers in Alzheimer's Disease. Tune in for our final May 2021 episode and learn something new about the different techniques used in AD diagnosis! Sections in this episode: Clinical Testing (1:58) Motor Assessments (7:39) Semantic Dementia (11:28) Sleep (14:03) -------------------------------------------------------------- You can find the numbered bibliography for this episode by clicking here, or the link below:https://drive.google.com/file/d/1pKecrNPbkMwJyc_z7Yeo3P0...2021-07-1518 min
AMiNDR: A Month in Neurodegenerative Disease Research180 - Clinical Markers of Alzheimer's Disease Part 1: May 2021In this episode, Maria goes over 22 papers from May 2021 on various cognitive tests for Alzheimer's disease and mild cognitive impairment. Paper topics include tests of general cognition, visual, verbal and auditory tests, dementia subtypes, machine learning, and language and culturally adapted tests. Sections in this episode: General cognition (2:00) Visual, verbal, and auditory testing (13:50) Other dementia subtypes (18:43) Machine learning (25.08)Language and cultural adaptations (29.32)-------------------------------------------------------------- To access the folder with all the bibliographies for 2021 so far, follow this link (it will be updated as we p...2021-07-1433 min
AMiNDR: A Month in Neurodegenerative Disease Research179 - Treatments targeting the Immune System & Glial Cells in Alzheimer's Disease: May 2021Abdullah takes you through papers from May 2021 on treatments to target the immune system and glial cells to treat Alzheimer's Disease. This includes things like coconut looking funguses and olive oil. These are just a few of the treatments being covered in this episode, tune in to find out more! Sections in this episode: Inflammasomes (3:31) Effects on Neuroinflammation (9:17) Miscellaneous Papers (24:20) -------------------------------------------------------------- To access the folder with all the bibliographies for 2021 so far, follow this link (it will be updated as we publish episodes and process...2021-07-1335 min
AMiNDR: A Month in Neurodegenerative Disease Research178 - Amyloid-Beta Pathology in Alzheimer's Disease: May 2021In the second part of our episodes on amyloid-beta, we focus on the ways abeta contributes to AD pathology. This ranges from its effects on the hippocampus and memory, to more mechanistic studies on ion homeostasis, lipid membrane integrity, and prion-like seeding, without forgetting our friend tau! Tune in for an episode as eventful as an episode of Game of Thrones where amyloid-beta wages a war on the good people of Westeros…or...wages a war on neurons. Enjoy! Sections in this episode: Amyloid-beta toxicity: (9:05) Iron Dyshomeostasis: (18:13) Prion-Like Seeding & Spread: (24:19) Miscel...2021-07-1038 min
AMiNDR: A Month in Neurodegenerative Disease Research177 - Treatments targeting Neurotransmitter Balance in Alzheimer's Disease: May 2021This episode of AMiNDR highlights literature published in May of 2021 that target neurotransmitter balance in Alzheimer's Disease. Greatest hits include cholinesterase inhibition, targeting glutamate excitotoxicity, and there's even a bonus paper on adrenergic transmission. Get excited! But maintain homeostasis. Sections in this episode: Targeting cholinesterases and oxidative stress (1.56) Targeting glutamate and excitotoxicity (22.33) Targeting Adrenergic Receptor (26.58) -------------------------------------------------------------- To access the folder with all the bibliographies for 2021 so far, follow this link (it will be updated as we publish episodes and process bibliographies), or click the following link be...2021-07-0930 min
AMiNDR: A Month in Neurodegenerative Disease Research176 - Familial Mutations, New Variants & Other Genetic Insights in Alzheimer's Disease: May 2021Wow - May 2021 is a productive month for AD genetics research! Tune in and Joseph will take you through 19 papers on studies to do with new variants, novel genetic insights, or studies on familial AD genetics. Sections in this episode: Methods for Gene and Pathway Discovery (1:46) GWAS, Transcriptome, Exome Sequencing (5:47) Miscellaneous (12:55) Familial AD (17:11) -------------------------------------------------------------- You can find the numbered bibliography for this episode by clicking here, or the link below:https://drive.google.com/file/d/1pKecrNPbkMwJyc_z7Yeo3P0frV...2021-07-0832 min
AMiNDR: A Month in Neurodegenerative Disease Research175 - Role of the Immune System & Glial Cells in Alzheimer's Disease: May 2021In this episode, Courtney takes you through the papers from May of 2021 on the Role of Immune systems and glial cells in Alzheimer's disease pathology! We will be discussing papers related to neuroinflammatory pathways in microglia and astrocytes, metabolism, peripheral inflammation and so much more! Tune in for this exciting episode! Sections in this episode: Microglia (02:07) Astrocytes (10:42) TREM2 (13:34) Metabolism (18:08) Periphery (24:53) -------------------------------------------------------------- You can find the numbered bibliography for this episode by clicking here, or the link below:https://drive.google.com/file/d/1...2021-07-0633 min
AMiNDR: A Month in Neurodegenerative Disease Research174 - Understanding Cognitive & Behavioural Changes in Alzheimer's Disease Part 2: May 2021In part 2 of this set of episodes, Ellen dives into papers on psychiatric changes and sleep disturbances in the context of AD. This includes research looking at depression, anxiety, agitation, circadian rhythm, and more in AD patients, animal models, and even clinical trials! There's sure to be something for everyone in this diverse set of papers, enjoy! Sections in this episode: Depression (2:27) Anxiety (5:26) Stress & PTSD (9:55) Agitation (13:30) Emotional Reactivity (17:13) Sleep & Circadian Rhythms (19:12) -------------------------------------------------------------- You can find the numbered bibliography for this episode by clicking...2021-07-0633 min
AMiNDR: A Month in Neurodegenerative Disease Research173 - APP Processing & Amyloid-Beta Aggregation in Alzheimer's Disease: May 2021Hello hello to fellow baptists, tauists and all protein aggregation enthusiasts! Sarah brings you 15 papers from the month of May on Amyloid-beta aggregation! This is the first part of a 2 episode series on understanding the role amyoid-beta plays in Alzheimer’s disease pathology, and you will hear about APP processing and localization, then amyloid-beta generation and aggregation. We will also throw a teaser on Amyloid-beta detection with a focus on plaques, so stay tuned if you need an update far from the screen while enjoying a walk, transiting to work, or going about your house chores.Are yo...2021-07-0339 min
AMiNDR: A Month in Neurodegenerative Disease Research172 - Detection of Amyloid, Tau, and other PET Targets in Alzheimer's Disease: May 2021In this episode, we’ll take a closer look at 13 papers published in May 2021, that rely on Positron emission tomography imaging (or PET) to detect amyloid and tau pathology in the brain, within the context of Alzheimer’s disease! Make sure to take a listen if you’re interested in learning more about tau and amyloid based detection, alternative PET tracers in AD research, or combining PET with different imaging modalities. Sections in this episode: Tau Based Detection (1:48) A-beta Based Detection (10:45) Tau and A-beta (18:10) Other PET Targets (19:33) ...2021-07-0222 min
AMiNDR: A Month in Neurodegenerative Disease Research171 - Understanding Cognitive & Behavioural Changes in Alzheimer's Disease Part 1: May 2021In part one of this 2-parter, Ellen will tell you all about the latest studies on cognition and motor deficits in AD. This includes mechanistic studies, as well as studies looking at potential treatment avenues for these symptoms. We hope you enjoy, and stay tuned for part 2 coming out soon! Sections in this episode: Cognition in AD patients (4:09) Cognition in animal models (9:38) Motor impairments (19:00) ------------------------------------------------------------- PLEASE FILL OUR SURVEY TO HELP US IMPROVE OUR PODCAST, AND ENTER A DRAW FOR A $30 GIFT CARD. Link if you prefer...2021-07-0124 min
AMiNDR: A Month in Neurodegenerative Disease Research170 - Hemodynamics, Metabolic Changes & EEG in Alzheimer's Disease: May 2021From working memory tasks to mouse models, and even to lexical semantics, Judy goes over a wide range of papers that study AD diagnosis using a variety of neuroimaging techniques. Check out this episode if you're interested in hearing about changes in cerebral blood flow, metabolism and EEG signals in the context of AD. You're sure to learn something new! Sections in this episode: Hemodynamics (1:05) Metabolic Changes (9:45) EEG (16:30) ------------------------------------------------------------- PLEASE FILL OUR SURVEY TO HELP US IMPROVE OUR PODCAST, AND ENTER A DRAW FOR A $30 GIFT CARD. Link...2021-06-3024 min
AMiNDR: A Month in Neurodegenerative Disease Research169 - Treatments targeting Neuroprotection and Synaptic Activity in Alzheimer's Disease: May 2021Anusha will guide you through 21 papers in this episode that target synaptic and neuroprotection as therapeutic intervention for Alzheimer's disease. She covers 3 topics including the use of pre-existing synthetic compounds, naturally occuring compounds, and designing and optimizing drugs to improve efficacy. All of these papers were published in May of 2021 so be sure to check it out to offer your neurons protection from ignorance! Sections in this episode: Using Pre-existing Synthetic Compounds (2.21) Using Naturally Occurring Compounds (12.36) Drug Design (26.35) ------------------------------------------------------------- PLEASE FILL OUR SURVEY TO HELP US IMPROVE OUR PODC...2021-06-2935 min
AMiNDR: A Month in Neurodegenerative Disease Research168 - Prevention and Intervention Strategies for Alzheimer's Disease: May 2021In this episode, Naila tackles 21 papers on diet, exercise, complementary therapies, cognitive training, and neurostimulation techniques. There's lots on the potential cellular mechanisms of exercise, several studies using Alzheimer's disease biomarkers as outcome measures, and even a paper on dog-assisted therapy! Hope you enjoy May's smattering of papers on pevention and intervention strategies for AD. Sections in this episode:Diet (2:52)Exercise (9:01)Multidomain Interventions (26.21)Cognitive training (34:29)Neuromodulatory techniques (37:30) ------------------------------------------------------------- PLEASE FILL OUR SURVEY TO HELP US IMPROVE OUR PODCAST, AND ENTER...2021-06-2646 min
AMiNDR: A Month in Neurodegenerative Disease Research167 - Vascular Contributions to Alzheimer Disease and Treatments Targeting the Vasculature: May 2021Elyn is back with more on all things vasculature! In this episode, she covers 14 papers that span many topics in the field of vascular contributions to Alzheimer disease - all the way from mechanisms linking cardiovascular and metabolic health to the Alzheimer pathology, to clinical studies associating cognitive symptoms with markers of cerebrovascular damage. Tune in to hear a perspective on AD that's outside of the amyloid cascade hypothesis! Sections in this episode:Overlap Between Cardiovascular Disease and AD (3:56)Clinical Studies on Cerebrovascular Pathology (12:20)Microvascular and Blood-Brain Barrier Changes i...2021-06-2534 min
AMiNDR: A Month in Neurodegenerative Disease Research166 - Imaging of Connectivity Changes in Alzheimer's Disease: May 2021Come join us as Judy covers all topics related to connectivity changes in Alzheimer's Disease. This episode features the latest research on both structural and functional connectivity using methods such as resting-state fMRI, DTI and EEG. Tune in to find out more! Sections in this episode: fMRI (2:00) MRI (10:51) Other (15:43) ------------------------------------------------------------- PLEASE FILL OUR SURVEY TO HELP US IMPROVE OUR PODCAST, AND ENTER A DRAW FOR A $30 GIFT CARD. Link if you prefer to copy/paste: https://amindr.hostedincanadasurveys.ca/417377?lang=enREGARDLESS...2021-06-2421 min
AMiNDR: A Month in Neurodegenerative Disease Research165 - Understanding ApoE in Alzheimer's Disease: May 2021In this episode, Courtney takes you through the papers from May 2021 on Understanding ApoE in Alzheimer's disease! We will be covering papers focused on genetic risk factors, biomarkers associated with ApoE status, risk factors for AD and finally, molecular mechanisms of ApoE! There is a wide range of topics so be sure tune in for this exciting episode! Sections in this episode:Genetic Risk Factors (2:12)Biomarkers in Alzheimer's Disease (7:15)Risk Factors of Alzheimer's Disease (12:10)Mechanisms of ApoE in Alzheimer's Disease (18:07) -------------------------------------------------------------- PLE...2021-06-2325 min
AMiNDR: A Month in Neurodegenerative Disease Research164 - Synaptic Transmission in Alzheimer's Disease: May 2021Ellen kicks off the May 2021 series with 20 papers all about synaptic transmission in Alzheimer's Disease. This includes topics like synaptic plasticity, neurotransmitters like acetylcholine, dopamine, and serotonin and how they're involved in AD, growth factors, morphological changes, and much more! Enjoy the show! Sections in this episode:Neurogenesis (5:11)Synaptic Plasticity (8:46)Neurotransmitter Signaling (18:26)Excitation/Inhibition Balance (28.07)Growth Factors (32:16)Morphological & Anatomical Changes (35:46)-------------------------------------------------------------- PLEASE FILL OUR SURVEY TO HELP US IMPROVE OUR PODCAST, AND ENTER A DRAW FOR A $30 GIFT CARD. ...2021-06-2245 min
AMiNDR: A Month in Neurodegenerative Disease Research159 - Clinical Markers of Alzheimer's Disease Part 2: March 2021In Part 2 of Clinical Markers of AD, Naila will take you through 10 papers on the diagnostic and prognostic value of neuropsychiatric, sensory, motor, or a combination of symptoms. You'll learn about pareidolia, extrapyramidal symptoms, wandering behaviour and more! Sections in this episode: Multiple Symptoms (2:47) Neuropsychiatric Symptoms (6:51) Sensory Symptoms (11:05) Motor Symptoms (18:23) -------------------------------------------------------------- To access the folder with all the bibliographies for 2021 so far, follow this link (it will be updated as we publish episodes and process bibliographies), or click the following link below:https://drive.g...2021-05-2525 min
AMiNDR: A Month in Neurodegenerative Disease Research155 - Prevention & Intervention Strategies for Alzheimer's Disease: March 2021We've got a tour de force of prevention and intervention papers for you today, covering vascular function, cognitive function, diet, exercise, neuromodulatory techniques and stem cell therapies. Naila will take you throuh 20 papers to update you on the AD literature from March 2021! --------------------------------------------------------------You can find the bibliography for this episode by clicking here. To access the folder with all the bibliographies for 2021 so far, follow this link (it will be updated as we publish episodes and process bibliographies), or click the following link below:https://drive.google.com/drive/folders/1N1...2021-05-2044 min
AMiNDR: A Month in Neurodegenerative Disease Research148 - Epidemiology of Risk Factors for Alzheimer's Disease, Part 1: March 2021In part 1 of epidemiological studies from March 2021, Naila will take you through 12 papers covering prevalence and incidence rates of AD, sociodemographic factors, the potential effects of loneliness, and more. Follow up with Part 2 if you'd like to learn about comorbidities and health risk factors linked to AD! -------------------------------------------------------------- You can find the bibliography for this episode by clicking here. To access the folder with all the bibliographies for 2021 so far, follow this link (it will be updated as we publish episodes and process bibliographies), or click the following link below:https://dri...2021-05-1229 min
AMiNDR: A Month in Neurodegenerative Disease Research102 - Cognitive or Clinical Indicators of Alzheimer's Disease Part 1: September 2020This episode, hosted by Naila, covers papers published in September 2020 that use cognitive testing as a diagnostic tool. These studies vary from validating and comparing existing tests, to refining them for specific applications, to correlating cognition with AD biomarkers. You’ll learn a bit about the variety of cognitive tests used, and how researchers are constantly building on existing tools to better predict the risk and progression of cognitive decline. Sections:Cognition & Imaging: 1.46Validation & Refinement of Existing Tests: 6.30Spatial & Facial Tests: 15.05Specific Populations: 21.18New Tools: 25.50 2021-01-2730 min
AMiNDR: A Month in Neurodegenerative Disease ResearchModifiable Risk Factors: Alzheimer's Disease June 2020 (Part 2)Having trouble keeping up with the literature in Alzheimer's Disease? We are here to help! You'll hear more from Naila in this episode on the papers published in June 2020 on modifiable risk factors in AD. This includes lifestyle and comorbidities. Enjoy!To receive the list of papers covered (with timestamps), please subscribe to our mailing list. You can do so by filling this form: --------> https://forms.gle/CVVbznAFM8pamdgk6 -------or by sending us an email at ---------> amindrpodcast@gmail.com-----------------------------------------------------------------------List of sections i...2020-08-0327 min
AMiNDR: A Month in Neurodegenerative Disease ResearchModifiable Risk Factors: Alzheimer's Disease June 2020 (Part 1)Having trouble keeping up with the literature in Alzheimer's Disease? We are here to help! This is the first of a two-part episode, where Naila covers the papers published in June 2020 on modifiable risk factors in AD, namely: cognitive reserve, diet, comorbidities, sleep, ... Stay tuned for the second part!To receive the list of papers covered (with timestamps), please subscribe to our mailing list. You can do so by filling this form: --------> https://forms.gle/CVVbznAFM8pamdgk6 -------or by sending us an email at ---------> amindrpodcast@gmail.com2020-08-0152 min