Shows
AMiNDR: A Month in Neurodegenerative Disease Research98 - Cerebrovascular changes in Alzheimer's Disease Part 2: September 2020In this episode, Elyn caps off the papers on Cerebrovascular Changes in AD from September 2020. There’s mounting evidence for a significant overlap between vascular disease and brain health, and Elyn dives into the newest papers exploring this relationship. Tune in to hear about how cerebral small vessel disease might be the mediator between arteriosclerosis and cognitive impairment, how APOE is related to microbleeds, and how ACE1 inhibitors might be relevant in AD! Sections in this episode: 1:50 - Relationship between Cerebral Small Vessel Disease & AD 11:40 - Cerebral Small Vessel Disease & AD Progre...2021-01-2220 min
AMiNDR: A Month in Neurodegenerative Disease Research97 - Brain Imaging of Structural Changes & Connectivity in Alzheimer's Disease, Part 2: September 2020In part 2 of this series, Bhumika continues the deep dive into imaging papers from September 2020 focusing on structural changes and connectivity of the brain, and subsequent white matter changes. Enjoy the episode and tune in to part 1 if you're interested in hearing about more new studies on this topic! ------------------------------------------------------------------ To receive the list of papers covered, please fill this form: --------> https://forms.gle/CVVbznAFM8pamdgk6 ------- or by tweeting at us: @AMiNDR_podcast ------------------------------------------------------------------ We would appreciate your feedback so we can better cater to your nee...2021-01-2220 min
AMiNDR: A Month in Neurodegenerative Disease Research96 - Changes to RNA, Transcription, and Translation in Alzheimer's Disease: September 2020In today's episode, Glory updates you on the latest studies from September 2020 on changes to RNA, transcription, and translation mechanisms that may contribute to Alzheimer's disease pathology. Enjoy! Sections in this episode: ncRNAs: 1:37 Histone acetylation: 9:55 -Omics: 14:44 Other: 24:52 ------------------------------------------------------------------ To receive the list of papers covered, please fill this form: --------> https://forms.gle/CVVbznAFM8pamdgk6 ------- or by tweeting at us: @AMiNDR_podcast ------------------------------------------------------------------ We would appreciate your feedback so we can better cater to your needs. 2021-01-2030 min
AMiNDR: A Month in Neurodegenerative Disease Research95 - Detecting Amyloid & Tau in Alzheimer's Disease: September 2020In this half-hour episode, Judy goes through September 2020 papers that look at diagnosing or characterizing Alzheimer's disease based on the detection of the proteins amyloid and tau in the brain and other structures. Topics include conventional and novel neuroimaging techniques, deep learning methods and retinal amyloid-beta. Tune in to find out more! Sections in this episode: PET Deep Learning Methods 1:06 Standardized Uptake Value Ratios 4:00 Mild Cognitive Impairment 12:05 Neuropsychological Tests and Executive Function 15:28 Other 17:49 Non-PET Retinal Amyloid-Beta...2021-01-1830 min
AMiNDR: A Month in Neurodegenerative Disease Research94 - Brain Imaging of Structural Changes & Connectivity in Alzheimer's Disease, Part 1: September 2020Bhumika updates you on the latest papers on brain imaging of structural changes and connectivity in AD! This includes MRI and PET imaging to characterize or diagnosis this disease, as well as new machine learning technology, and more! Enjoy, and look out for part 2 soon! ------------------------------------------------------------------ To receive the list of papers covered, please fill this form: --------> https://forms.gle/CVVbznAFM8pamdgk6 ------- or by tweeting at us: @AMiNDR_podcast ------------------------------------------------------------------ We would appreciate your feedback so we can better cater to your needs. You can f...2021-01-1524 min
AMiNDR: A Month in Neurodegenerative Disease Research93 - Inflammation, Glial Cells & TREM2 in Alzheimer's Disease, Part 2: September 2020Courtney is back with Part 2 of Inflammation, Glial Cells and TREM2 papers published in September of 2020! If you haven't already, check out Part 1 in episode #91. In this exciting sequel, she discusses methods to study inflammation, astrocytes in inflammation and peripheral immunity. ------------------------------------------------------------------ To receive the list of papers covered, please fill this form: --------> https://forms.gle/CVVbznAFM8pamdgk6 ------- or by tweeting at us: @AMiNDR_podcast ------------------------------------------------------------------ We would appreciate your feedback so we can better cater to your needs. You can fill our feedback...2021-01-1526 min
AMiNDR: A Month in Neurodegenerative Disease Research92 - Fluid Biomarkers for Alzheimer's Disease Part 2: September 2020Elyn is back with more on fluid biomarkers for Alzheimer’s Disease from September 2020 papers. Here, she covers new candidate biomarkers including panels of lipids, soluble TREM2, and methylation sites on known risk genes. She also dives into insight into APOE4 mechanisms revealed by biomarkers, the stark overlap between vascular dementia and Alzheimer’s disease, and much more. This is a long one, but definitely worth a listen! Sections in this episode: Lipids - 6 papers - 3:22 Hormones/lipoproteins - 3 papers - 13:05 Metabolites - 4 papers - 17:31 Inflammation...2021-01-1346 min
AMiNDR: A Month in Neurodegenerative Disease Research91 - Inflammation, Glial Cells & TREM2 in Alzheimer's Disease, Part 1: September 2020Courtney updates you on all the new publications from September 2020 about inflammation, glial cells, and TREM2, in the context of Alzheimer's disease. There were a lot of papers on these topics, so we split it up into 2 episodes. Stay tuned for part 2 coming soon! ------------------------------------------------------------------ To receive the list of papers covered, please fill this form: --------> https://forms.gle/CVVbznAFM8pamdgk6 ------- or by tweeting at us: @AMiNDR_podcast ------------------------------------------------------------------ We would appreciate your feedback so we can better cater to your needs. You can fill...2021-01-1132 min
AMiNDR: A Month in Neurodegenerative Disease Research90 - New Genetic Variants in Alzheimer's Disease: September 2020Is the ever-expanding genetic landscape of Alzheimer’s disease overwhelming for you? Joseph will help you catch up on all the literature about new genes or variants linked to Alzheimer’s Disease in September 2020. Sections in this episode: Novel Gene Discovery - 1:08 New Variant Discovery - 10:24 Testing Associations in Novel Genes - 13:50 Miscellaneous - 18:33 ------------------------------------------------------------------ To receive the list of papers covered, please fill this form: --------> https://forms.gle/CVVbznAFM8pamdgk6 ------- or by tweeting at us: @AMiNDR_podcast ...2021-01-0823 min
AMiNDR: A Month in Neurodegenerative Disease Research89 - Treatments targeting amyloid-beta-mediated toxicity in Alzheimer's Disease: September 2020In this episode, Marcia updates you on 8 papers from September 2020 on the development of treatments that target amyloid-beta mediated toxicity to treat Alzheimer's disease. Tune in to hear more! ------------------------------------------------------------------ To receive the list of papers covered, please fill this form: --------> https://forms.gle/CVVbznAFM8pamdgk6 ------- or by tweeting at us: @AMiNDR_podcast ------------------------------------------------------------------ We would appreciate your feedback so we can better cater to your needs. You can fill our feedback form here ----------> https://forms.gle/5aq2JyrT6g4P1m8v6 ...2021-01-0613 min
AMiNDR: A Month in Neurodegenerative Disease Research88 - Non-Pharmacological Treatment Approaches for Alzheimer's Disease: September 2020In today’s episode, you’ll hear about the latest developments in preventing or treating AD using non-pharmacological approaches, such as cognitive interventions, stimulation techniques, and exercise. Naila covers clinical trials in humans and mechanistic studies in animal models, all in 19 papers. Enjoy! ------------------------------------------------------------------ To receive the list of papers covered, please fill this form: --------> https://forms.gle/CVVbznAFM8pamdgk6 ------- or by tweeting at us: @AMiNDR_podcast ------------------------------------------------------------------ We would appreciate your feedback so we can better cater to your needs. You can fill our feed...2021-01-0638 min
AMiNDR: A Month in Neurodegenerative Disease Research87 - Cognitive & Behavioural Changes in Alzheimer's Disease: September 2020Interested in the behavioural aspects of AD such as changes to cognition, emotion, sleep, sensory and verbal abilities, and learning and memory? Look no further. Anusha will guide you through the literature that was published on these topics in September (2020) to help you start the new year off on the right foot. Sections in this episode: 1.47 Cognition/Emotional Processing/Depression 10.35 Sleep 17.24 Verbal/Audition/Olfaction 25.04 Learning and Memory ------------------------------------------------------------------ To receive the list of papers covered, please fill this form: --------> https://forms.gle...2021-01-0431 min
AMiNDR: A Month in Neurodegenerative Disease Research86 - Treatments Targeting the Immune System & Glia in Alzheimer's Disease: September 2020Happy New Year from the AMiNDR team! In our first episode of 2021, Abdullah presents on the modulation of inflammatory response in AD, with a big emphasis on microglia, the forgotten heroes in his mind, they clean, repair and protect your brain. Hopefully by the end of the episode you’ll know more about why changing their behaviour could be the treatment we are looking for. Sections in this episode: Targeting NLRP3: 2:00 Favouring M2 over M1 for microglia: 5:57 Other: 11:00 ------------------------------------------------------------------ To receive the list of papers covered...2021-01-0320 min
AMiNDR: A Month in Neurodegenerative Disease Research85 - Fluid Biomarkers for Alzheimer's Disease Part 1: September 2020Interested in the mission to accurately diagnose Alzheimer’s disease with a blood test? This episode is perfect for you. In this two-part episode on Fluid Biomarkers in AD from September 2020 papers, Elyn explains the ATN framework for AD diagnosis, and covers papers focused on fluid biomarkers relating to amyloid, tau, and neurodegeneration. She also touches on a few new methods for biomarkers researchers. Tune in to hear about how storage conditions can affect measurements, how assay platforms compare, and new methods for isolating exosomes! Sections in this episode: Combination of the Classics: 3:44 Amyloid beta...2020-12-2330 min
AMiNDR: A Month in Neurodegenerative Disease Research84 - APP processing and amyloid-beta aggregation in Alzheimer's Disease: September 2020In this episode, Jacques will tell you about new peer-reviewed publications from September 2020 on mechanisms of APP processing and protein aggregation in the context of Alzheimer's disease. This includes aggregation of amyloid-beta as well as other proteins such as tau and alpha-synuclein. Enjoy the episode! ------------------------------------------------------------------ To receive the list of papers covered, please fill this form: --------> https://forms.gle/CVVbznAFM8pamdgk6 ------- or by tweeting at us: @AMiNDR_podcast ------------------------------------------------------------------ We would appreciate your feedback so we can better cater to your needs. You can f...2020-12-2229 min
AMiNDR: A Month in Neurodegenerative Disease Research83 - Treatments targeting amyloid-beta aggregation and more in Alzheimer's Disease: September 2020In this episode, Marcia covers papers published in September 2020 that focus on the latest in novel drug development in AD. We especially talk about papers targeting amyloid-beta aggregation, BACE-1 inhibitors, gamma-secretase, immunotherapy for AD and more! Tune in to learn more. 5:46 - BACE-1 9:09 - Gamma secretase11:12 - More papers on amyloid-beta aggregation------------------------------------------------------------------ To receive the list of papers covered, please fill this form: --------> https://forms.gle/CVVbznAFM8pamdgk6 ------- or by tweeting at us: @AMiNDR_podcast ------------------------------------------------------------------ We would appreciate your feedback so we can...2020-12-2127 min
AMiNDR: A Month in Neurodegenerative Disease Research82 - Metabolism & Mitochondrial Dysfunction in Alzheimer's Disease: September 2020Is your research on diet and nutrition and Alzheimer’s disease? Or maybe you are diving deeper into the role of carbs and fat metabolism, and are interested in mitochondrial function in neurodegenerative diseases? Then stay here! Sarah covers 13 papers from our September 2020 harvest with topics ranging from the ketogenic diet to the lipidome. List of sections:Diet and nutrition: 2.18Carbohydrate and lipid metabolism: 5.44Protective aspects of metabolism: 14.23Mechanisms of mitochondrial function and dysfunction: 18.00------------------------------------------------------------------ To receive the list of papers covered, please fill...2020-12-2126 min
AMiNDR: A Month in Neurodegenerative Disease Research81 - Cerebrovascular changes in Alzheimer's Disease Part 1: September 2020Elyn is back to cover the latest findings relating to the cerebrovasculature in Alzheimer disease! In this two part episode covering papers from September 2020, you’ll hear about how aging and systemic inflammation can influence the blood-brain barrier, how circulating “good cholesterol” can protect the blood vessels and may be dysfunctional in AD, and a whole lot about cerebral small vessel disease. ------------------------------------------------------------------ To receive the list of papers covered, please fill this form: --------> https://forms.gle/CVVbznAFM8pamdgk6 ------- or by tweeting at us: @AMiNDR_podcast ------------------------------------------------------------------ We would...2020-12-2024 min
AMiNDR: A Month in Neurodegenerative Disease Research80 - Understanding ApoE in Alzheimer's Disease: September 2020In this episode, Courtney will update you on papers published in September 2020 on the Disease Mechanisms of ApoE. You will hear about cognitive impacts of ApoE, ethnic variability in ApoE, Neuroimaging of ApoE isoforms, and even some additional genetic implications of ApoE.List of Sections:Impact on Cognitive Abilities: 3.00Ethnic Variability Behind ApoE Isoforms: 14.17Neuroimaging with ApoE Isoforms: 18.20Genetic Mechanisms of ApoE: 24.07------------------------------------------------------------------ To receive the list of papers covered, please fill this form: --------> https://forms.gle/CVVbznAFM8pamdgk6 ------- or by tweeting at us...2020-12-1833 min
AMiNDR: A Month in Neurodegenerative Disease Research79- Treatments Targeting Oxidative Stress, Metabolism, & Behaviour in Alzheimer's Disease: September 2020If you can’t quite decide which episode to listen to, maybe give this one a try. We’re covering preclinical models of AD as it pertains to mitochondria, autophagy, metabolism, behaviour, and much much more. Join Anusha so she doesn’t have to explore all these exciting papers all by herself! List of Sections:Mitochondria: 1.31Autophagy/Metabolism: 5.34Behaviour: 12.12Other: 23.07------------------------------------------------------------------ To receive the list of papers covered, please fill this form: --------> https://forms.gle/CVVbznAFM8pamdgk6 ------- or by tweetin...2020-12-1835 min
AMiNDR: A Month in Neurodegenerative Disease Research78 - Multi-Targeted Treatment Approaches for Alzheimer's Disease Part 2 + Gene Therapy: September 2020This episode is the second half of a two part series covering papers published in September 2020 on treatment approaches with multiple targets for Alzheimer’s disease. For part 1 of this series, check out episode 74! In this part, we’ll take a look at papers targeting many different AD processes, including oxidative stress, cholinesterase activity, and amyloid beta formation. The final paper in this episode will cover a new study using gene therapy to target AD. ------------------------------------------------------------------ Sections in this episode: 2:04 Treatments with multiple targets 18:05 (1 paper) Gene therapy ------------------------------------------------------------------ To receive the list...2020-12-1420 min
AMiNDR: A Month in Neurodegenerative Disease Research77 - Oxidative Stress, Autophagy and the Gut Microbiome in Alzheimer's Disease: September 2020You'll hear about how mechanisms of oxidative stress, autophagy and the gut microbiome may contribute to AD pathology, as Abdullah updates you on the new papers from September 2020 on these topics. Enjoy! Sections in this episode: Oxidative stress (6) 2:15Autophagy (2) 13:52Gut microbiome (1) 19:53------------------------------------------------------------------ To receive the list of papers covered, please fill this form: --------> https://forms.gle/CVVbznAFM8pamdgk6 ------- or by tweeting at us: @AMiNDR_podcast ------------------------------------------------------------------ We would appreciate your feedback so we can better cater to your needs. You c...2020-12-1132 min
AMiNDR: A Month in Neurodegenerative Disease Research76 - The Genetic Landscape of Sex Differences and More in Alzheimer's Disease: September 2020In this episode, Judy goes over papers published in September 2020 that focus on sex differences in Alzheimer’s disease. We also cover a few papers that did not quite fit into our other genetics-themed episodes, including AD-related stigma, lewy body dementia and overlapping risk factors of AD and Parkinson’s disease. Tune in to learn more! Sections in this episode: APOE 1:10 Female-specific AD risks 4:45 CERAD 11:32 Diabetes 15:25 Other 16:38 To learn more about the Bob and Diane Fund, "an award for visual storytelling about Alzheimer's and dementia", make sure you check the website...2020-12-1024 min
AMiNDR: A Month in Neurodegenerative Disease Research75 - Risk Factors in Alzheimer's Disease Part 3: September 2020Naila is back to round off the non-genetic risk factors for September, with 6 papers on a variety of potential comorbidities, and 7 more on epidemiological studies and the interaction of various modifiable risk factors. We cover a lot of ground and geographic locations this episode, so buckle in for a solid - but hopefully riveting - half hour of information! ------------------------------------------------------------------ To receive the list of papers covered, please fill this form: --------> https://forms.gle/CVVbznAFM8pamdgk6 ------- or by tweeting at us: @AMiNDR_podcast ------------------------------------------------------------------ We would ap...2020-12-0829 min
AMiNDR: A Month in Neurodegenerative Disease Research74 - Multi-Targeted Treatment Approaches for Alzheimer's Disease Part 1: September 2020In this episode, Alex will be covering papers published in September 2020 within the category of novel drug development, that focus on multi-targeted approaches to Alzheimer’s disease treatment. We’ll take a look at papers targeting many different AD processes, including oxidative stress, cholinesterase activity, and amyloid beta formation. Part 2 will be coming out shortly! ------------------------------------------------------------------ To receive the list of papers covered, please fill this form: --------> https://forms.gle/CVVbznAFM8pamdgk6 ------- or by tweeting at us: @AMiNDR_podcast ------------------------------------------------------------------ We would appreciate your feedback so we can be...2020-12-0624 min
AMiNDR: A Month in Neurodegenerative Disease Research73 - Risk Factors for Alzheimer's Disease Part 2: September 2020In this episode, Naila goes through 13 papers that explore how benzodiazepine and anticholinergic drug use affect individuals with dementia, whether exposure to certain air pollutants increase the risk of AD, and how cognitive reserve - whether in the form of occupation, bilingualism or education - may protect against cognitive decline. Enjoy! ------------------------------------------------------------------ To receive the list of papers covered, please fill this form: --------> https://forms.gle/CVVbznAFM8pamdgk6 ------- or by tweeting at us: @AMiNDR_podcast ------------------------------------------------------------------ We would appreciate your feedback so we can better cater to...2020-12-0432 min
AMiNDR: A Month in Neurodegenerative Disease Research72 - Synaptic Transmission in Alzheimer's Disease: September 2020What is it about neurotransmission that is so difficult to regulate in Alzheimer's? Anusha will tell you in this episode, so tune in if you're interested in the role of cholinergic and glutamatergic transmission, or the role of the hippocampus in AD. ------------------------------------------------------------------ To receive the list of papers covered, please fill this form: --------> https://forms.gle/CVVbznAFM8pamdgk6 ------- or by tweeting at us: @AMiNDR_podcast ------------------------------------------------------------------ We would appreciate your feedback so we can better cater to your needs. You can fill o...2020-12-0320 min
AMiNDR: A Month in Neurodegenerative Disease Research71 - Amyloid-beta mediated toxicity: Alzheimer's Disease September 2020This episode, hosted by Jacques, explores many facets of amyloid-beta mediated toxicity. First, we run through the structure-toxicity relationships of mutant amyloid-beta. Second, we investigate the interaction of amyloid-beta oligomers with membranes and their effect on vesicular trafficking and endocytosis. And lastly, we finish the episode on insights into the effects of amyloid-beta on neurotransmitter systems in AD. ------------------------------------------------------------------ To receive the list of papers covered, please fill this form: --------> https://forms.gle/CVVbznAFM8pamdgk6 ------- or by tweeting at us: @AMiNDR_podcast ------------------------------------------------------------------ We would apprecia...2020-12-0226 min
AMiNDR: A Month in Neurodegenerative Disease Research70 - Risk Factors in Alzheimer's Disease Part 1: September 2020In the first of 3 episodes on AD risk factors for September 2020, Naila covers some of the most studied (arguably) modifiable risk factors, including diet, exercise and sleep. You'll also hear about the effects of hormones and common comorbidities such as diabetes and cardiovascular disease. As many of these factors relate to one another, this will give you a good overview of the literature on common AD risk factors in September 2020! Major Sections:Diet (1.00)Body Mass, Diabetes, Cardiovascular Factors (6.54)Exercise (15.30)Hormones, Circadian Rhythm, Sleep (23.17) ...2020-11-3029 min
AMiNDR: A Month in Neurodegenerative Disease Research69 - Treatments Targeting Synaptic Transmission in Alzheimer's Disease: September 2020Are you invested in the role of neurotransmission in Alzheimer’s disease? Well then buckle in because in this episode, Anusha will go over the latest and greatest compounds that target disease state changes to synaptic transmission in animal and in vitro models of Alzheimer’s.This episode covers the papers published in September of 2020 that use animal models and tissue culture to test the effects of novel compounds for their effects in rescuing synaptic transmission changes in AD. We’ll have 8 papers on cholinergic system, 3 on the glutamatergic neurotransmission, and 1 on G-protein coupled receptors. Ma...2020-11-3024 min
AMiNDR: A Month in Neurodegenerative Disease ResearchSPECIAL: On Scicomm & Podcasting, with BrainBuzz!Sarah and Elyn are joined by Kyle and Drake from BrainBuzz Podcast to share our journey, growth, and challenges with starting a podcast for science communication in Psychology for them, and Neuroscience for us. What is it like to talk about our research at cocktail parties? What does starting a podcast require? How does one manage to say "neurodegenerative" without stuttering? This is the second of two crossover episodes. Listen to the first part on Apple Podcast on BrainBuzz: https://podcasts.apple.com/ca/podcast/brain-buzz/id1334344532 There, you will...2020-11-2837 min
AMiNDR: A Month in Neurodegenerative Disease Research67 - More on Disease Mechanisms in Alzheimer's Disease: August 2020In this episode, Elyn takes you through a very diverse set of papers on Alzheimer’s disease mechanisms - catching all of the papers that didn’t slot nicely into other episodes. The topics span a wide range from how the reflex of your pupils adjusting to light may be an early indicator of AD, to potentially pathogenic crystals in post-mortem AD brain tissue. There are also several RNA-based papers and signalling pathway papers in the mix, so tune in to learn something new!------------------------------------------------------------------ To receive the list of papers covered, please fill this form...2020-11-2723 min
AMiNDR: A Month in Neurodegenerative Disease Research66- Tau and Other Protein-Related Pathology: Alzheimer's Disease August 2020Today’s episode is on protein expression, aggregation, misfolding and pathology, with an emphasis on tau pathology in Alzheimer’s Disease and we are rounding off the papers published in August 2020. If you are interested in tau spreading in neurodegenerative disease, protein dysfunction in disease and new potential therapeutic targets, Alyssa has got you covered. ------------------------------------------------------------------ To receive the list of papers covered, please fill this form: --------> https://forms.gle/CVVbznAFM8pamdgk6 ------- or by tweeting at us: @AMiNDR_podcast ------------------------------------------------------------------ We would appreciate your feedback so we can be...2020-11-2736 min
AMiNDR: A Month in Neurodegenerative Disease Research65 - GWAS, Transcriptomics, & New Tools for Genetic Research: Alzheimer’s Disease August 2020Naila is back to round off our risk factors section with an episode on genome-wide association studies, transcriptomic research, combining genetics and neuroimaging data, and new tools to make all this work easier. Tune in to learn more about the techniques used to study the genetic underpinnings of AD, and perhaps to learn some long gene names to impress people at the next party you attend - especially if you can still remember them by then. ------------------------------------------------------------------ To receive the list of papers covered, please fill this form: --------> https://forms.gle/CVVbznAFM8pamd...2020-11-2533 min
AMiNDR: A Month in Neurodegenerative Disease Research64 - Cerebrovascular Changes : Alzheimer's Disease August 2020With over 700km of blood vessels in the brain, it’s no surprise that brain and vascular health are closely related. In this episode, Elyn takes you through papers published in August 2020 on cerebrovascular changes in AD. Tune in to learn more about amyloid clearance, platelet aggregation, and changes in the neurovascular unit over the course of the disease.------------------------------------------------------------------ To receive the list of papers covered, please fill this form: --------> https://forms.gle/CVVbznAFM8pamdgk6 ------- or by tweeting at us: @AMiNDR_podcast ------------------------------------------------------------------ We would app...2020-11-2325 min
AMiNDR: A Month in Neurodegenerative Disease Research63 - More on Diagnostic Tools: Alzheimer's Disease August 2020Today’s episode is all about Diagnostic Tools and Imaging papers published in August 2020. As you will soon see, these papers explore a wide range of topics including potential biomarkers of AD, hormone markers and EEG analyses. While these papers didn’t quite fit into some of the other diagnostic tools and Imaging subthemes discussed in previous and upcoming episodes (such cognitive testing, imaging tools, fluid biomarkers, and using Amyloid and tau level for diagnosis and classification), they are just as important. So tune in to find out more!------------------------------------------------------------------ To receive the list of paper...2020-11-2316 min
AMiNDR: A Month in Neurodegenerative Disease Research62 - Novel Drug Development-Part 3: Alzheimer's Disease June 2020n this episode, Alex will be covering papers published in August 2020 within the category of novel drug development, that focus on multi-targeted approaches to Alzheimer’s disease treatment, and a few papers that don’t quite fit under any of the themes we’ve covered so far. We’ll take a look at studies targeting many different AD processes, including oxidative stress, cholinesterase activity, and amyloid beta formation.------------------------------------------------------------------ To receive the list of papers covered, please fill this form: --------> https://forms.gle/CVVbznAFM8pamdgk6 ------- or by tweeting at us: @AMiNDR_p...2020-11-2225 min
AMiNDR: A Month in Neurodegenerative Disease Research61 - More on Biomarkers: Alzheimer's Disease August 2020Naila covers a wide variety of biomarkers and topics from papers published in August 2020 on Alzheimer's disease: identifying biomarkers of cognition and memory in cognitively unimpaired older adults, biomarkers that can help predict AD progression and differentiation, new biomarker assays and tools for improved diagnosis, EEG, metabolic profiling... ------------------------------------------------------------------ To receive the list of papers covered, please fill this form: --------> https://forms.gle/CVVbznAFM8pamdgk6 ------- or by tweeting at us: @AMiNDR_podcast ------------------------------------------------------------------ We would appreciate your feedback so we can better cater to your needs. ...2020-11-2032 min
AMiNDR: A Month in Neurodegenerative Disease Research60 - Novel Drug Development Part 2 : Alzheimer's Disease August 2020In this episode, Marcia talks about papers published in August 2020 within the novel drug development category that focus on targeting tau, the cholinergic system, mitochondria, metabolism and the immune system, as a way to combat Alzheimer's Disease. Check out episode 56 for the first part, where you'll hear more on novel drug development targeting Amyloid-beta production, aggregation, and toxicity.------------------------------------------------------------------ To receive the list of papers covered, please fill this form: --------> https://forms.gle/CVVbznAFM8pamdgk6 ------- or by tweeting at us: @AMiNDR_podcast ------------------------------------------------------------------ We would appreci...2020-11-2035 min
AMiNDR: A Month in Neurodegenerative Disease Research59 - Detecting Amyloid & Tau in the Brain Part 2: Alzheimer's Disease August 2020Judy covers the second half of papers released in August 2020 on amyloid or tau protein detection in the brain. This selection features mouse models, machine learning, mass spectrometry and other cool methods to detect these biomarkers of Alzheimer’s disease. Check episode 39 for the first part.We hope you find this episode useful and accessible.------------------------------------------------------------------ To receive the list of papers covered, please fill this form: --------> https://forms.gle/CVVbznAFM8pamdgk6 ------- or by tweeting at us: @AMiNDR_podcast ------------------------------------------------------------------ We would appreciate your feed...2020-11-1918 min
AMiNDR: A Month in Neurodegenerative Disease Research58 - Blood Biomarkers: Alzheimer's Disease August 2020Today we have another episode focused on the latest findings in Alzheimer’s disease blood biomarkers research, where Elyn covers abstracts from papers published in August 2020. These papers were clumped together based on the fact that they all focused on measuring something in the blood to either predict or diagnose Alzheimer disease – making them blood biomarkers!In this episode, you’ll hear about a range of analytes that were useful in diagnosing, or predicting Alzheimer disease. Some of these are the usual suspects of amyloid, tau, and neurodegeneration markers like neurofilament light,... You’ll also hear about some new...2020-11-1833 min
AMiNDR: A Month in Neurodegenerative Disease Research57 - Metabolism, Mitochondrial (Dys)function, Oxidative Stress, Autophagy, & Gut Microbiome: Alzheimer's Disease August 2020Feeling PERK-y? An eclectic assortment of papers that address Alzheimer’s disease mechanisms in various ways awaits you in this episode. Anusha Kamesh will be guiding your journey through papers released in August of 2020 that concern metabolism, mitochondrial function, oxidative stress, autophagy, and gut microbiome------------------------------------------------------------------ To receive the list of papers covered, please fill this form: --------> https://forms.gle/CVVbznAFM8pamdgk6 ------- or by tweeting at us: @AMiNDR_podcast ------------------------------------------------------------------ We would appreciate your feedback so we can better cater to your needs. You can fi...2020-11-1834 min
AMiNDR: A Month in Neurodegenerative Disease Research56 - Novel Drug Development Part 1: Alzheimer's Disease August 2020Marcia will tell you about papers published in August 2020 within the Novel drug development category that focus on all things Amyloid-beta. She will cover research focussed on targeting Amyloid-beta production, aggregation, and toxicity, as a way to combat AD.------------------------------------------------------------------ To receive the list of papers covered, please fill this form: --------> https://forms.gle/CVVbznAFM8pamdgk6 ------- or by tweeting at us: @AMiNDR_podcast ------------------------------------------------------------------ We would appreciate your feedback so we can better cater to your needs. You can fill our feedback form here 2020-11-1834 min
AMiNDR: A Month in Neurodegenerative Disease Research55 - Refining & Repurposing Treatments: Alzheimer's Disease August 2020We may not have a disease-modifying agent for Alzheimer’s disease yet, but there are several approved medications that can help slow down the progression of the disease. Can we improve these medications and make them more potent? Are there different ways we can administer them to improve their efficacy? And while we are talking about approved medications, are there any hidden gems on the market that are being used to treat let’s say diabetes, or hypertension..that can also help in treating AD? This is what this episode is about! Stay tuned with AMiNDR to hear Sarah cove...2020-11-1630 min
AMiNDR: A Month in Neurodegenerative Disease Research54 - CSF Biomarkers: Alzheimer's Disease August 2020In this episode, Alex covers the latest research involving CSF biomarkers as a critical diagnostic tool in Alzheimer’s Disease identification and treatment. You’ll hear about some of the more typical clinical CSF biomarkers seen in AD, as well as the signature CSF AD biomarker profile, and you’ll also learn about how some of these CSF biomarkers relate to the different stages of AD progression and severity. ------------------------------------------------------------------ To receive the list of papers covered, please fill this form: --------> https://forms.gle/CVVbznAFM8pamdgk6 ------- or by tweeting at us: @AMiND...2020-11-1620 min
AMiNDR: A Month in Neurodegenerative Disease Research53 - Understanding ApoE: Alzheimer's Disease August 2020In this episode, Courtney will update you on papers published in August 2020 on the genetic landscapes of ApoE. You will hear about models of ApoE, ethnic variability in ApoE, clinical implications of ApoE, and even some molecular mechanisms of ApoE.------------------------------------------------------------------ To receive the list of papers covered, please fill this form: --------> https://forms.gle/CVVbznAFM8pamdgk6 ------- or by tweeting at us: @AMiNDR_podcast ------------------------------------------------------------------ We would appreciate your feedback so we can better cater to your needs. You can fill our feedback form her...2020-11-1625 min
AMiNDR: A Month in Neurodegenerative Disease ResearchSPECIAL: ONE YEAR WITH AMINDR!What role does social media play in academia and science communication nowadays? How can we keep our biases from interfering with fair reporting and objective coverage? Do we need to revise our inclusion criteria for the papers we cover? How relevant is the categorization of research by disease when there is so much overlap in underlying mechanisms? And how much responsibility do we hold through our podcast in shaping people’s understanding of these papers?Today you will hear from Sarah Louadi, Ellen Koch, Elyn Rowe, and Naila Kuhlmann, for a special celebratory episode for our anniversary. Tha...2020-11-151h 07
AMiNDR: A Month in Neurodegenerative Disease ResearchSPECIAL: ONE YEAR WITH AMINDR!What role does social media play in academia nowadays? How can we keep our biases from interfering with fair reporting and objective coverage? Do we need to revise our inclusion criteria for the papers we cover? How relevant is the categorization of research by disease when there is so much overlap in underlying mechanisms? And how much responsibility do we hold through our podcast in shaping people’s understanding of these papers?Today you will hear from Sarah Louadi, Ellen Koch, Elyn Rowe, and Naila Kuhlmann, for a special celebratory episode for our anniversary. That’s right, Novem...2020-11-141h 07
AMiNDR: A Month in Neurodegenerative Disease Research51 - Cognitive Testing for Diagnosis: Alzheimer's Disease August 2020Ellen tells you about the latest papers on cognitive testing for AD and mild cognitive impairment! This includes papers that delve deeper into how cognition is affected in AD and other disorders, and in some cases compare these changes to neurological data. Other papers validate existing cognitive assessment tools, or describe brand new ones, including new analysis algorithms and computer-based testing. Enjoy the episode! ------------------------------------------------------------------ To receive the list of papers covered, please fill this form: --------> https://forms.gle/CVVbznAFM8pamdgk6 ------- or by tweeting at us: @AMiNDR_podcast ...2020-11-1335 min
AMiNDR: A Month in Neurodegenerative Disease Research50 - Amyloid-beta Aggregation: Alzheimer's Disease August 2020Listen to Jacques as he recites tongue-twisters and updates you on the latest papers on amyloid-beta aggregation and toxicity in AD from August, 2020! We hope you like the episode, and if you're interested in amyloid pathology in AD, you might want to check out Jacques' last episode as well, episode 47 on APP processing. ------------------------------------------------------------------ To receive the list of papers covered, please fill this form: --------> https://forms.gle/CVVbznAFM8pamdgk6 ------- or by tweeting at us: @AMiNDR_podcast ------------------------------------------------------------------ We would appreciate your feedback so we can bett...2020-11-1324 min
AMiNDR: A Month in Neurodegenerative Disease Research49 - Epigenetics, Specific Molecular Pathways & Genetic Models: Alzheimer's Disease August 2020The genetic landscape of Alzheimer's disease can be overwhelmingly broad. In this episode, Joseph is back to tell you about peer-reviewed research dealing with epigenetics, non-APOE related genetic pathways and a couple new genetic models that have been published in August 2020. Enjoy! ------------------------------------------------------------------ To receive the list of papers covered, please fill this form: --------> https://forms.gle/CVVbznAFM8pamdgk6 ------- or by tweeting at us: @AMiNDR_podcast ------------------------------------------------------------------ We would appreciate your feedback so we can better cater to your needs. You can fill our feedb...2020-11-1325 min
AMiNDR: A Month in Neurodegenerative Disease Research48 - Preclinical Testing Part 3: Alzheimer's Disease August 2020Join Anusha as she dives into papers published from August of 2020 that uncovers the effects of potential therapeutics in animal models for Alzheimer's Disease. In the first section, she covers research that targets multiple aspects of Alzheimer's pathology. In the second section, she focuses on research that aims to improve cognition and memory in animal models. ------------------------------------------------------------------ To receive the list of papers covered, please fill this form: --------> https://forms.gle/CVVbznAFM8pamdgk6 ------- or by tweeting at us: @AMiNDR_podcast ------------------------------------------------------------------ We would appreciate your feedback...2020-11-1126 min
AMiNDR: A Month in Neurodegenerative Disease Research47 - APP processing: Alzheimer's Disease August 2020In this episode, Jacques updates you on the newest papers related to amyloid precursor protein processing in AD! You'll hear about the gamma secretase complex, the influence of accessory proteins on amyloidogenic cleavages of APP, and APP glycosylation patterns, among other interesting topics! Enjoy. ------------------------------------------------------------------ To receive the list of papers covered, please fill this form: --------> https://forms.gle/CVVbznAFM8pamdgk6 ------- or by tweeting at us: @AMiNDR_podcast ------------------------------------------------------------------ We would appreciate your feedback so we can better cater to your needs. You can fill o...2020-11-1112 min
AMiNDR: A Month in Neurodegenerative Disease Research46 - Imaging Tools for Diagnosis Part 2: Alzheimer's Disease August 2020Bhumika is back to tell you more about the latest tools and techniques in imaging to diagnosis Alzheimer's disease from papers published in August 2020. This includes PET imaging, MRI, and machine learning techniques. If you're interested in this topic, make sure to check out Part 1, which is episode 43, as well. Enjoy! ------------------------------------------------------------------ To receive the list of papers covered, please fill this form: --------> https://forms.gle/CVVbznAFM8pamdgk6 ------- or by tweeting at us: @AMiNDR_podcast ------------------------------------------------------------------ We would appreciate your feedback so we can better cater to...2020-11-0918 min
AMiNDR: A Month in Neurodegenerative Disease Research45 - Non-pharmacological Treatment Approaches: Alzheimer's Disease August 2020In this episode, Naila takes you through peer-reviewed research published in August 2020, on the many non-pharmacological approaches to treating AD. She covers a lot of territory, from diet-based approaches, to exercise programs and their potential underlying mechanisms, to brain stimulation and some more esoteric treatments. This episode is sure to leave you with some food for thought. ------------------------------------------------------------------ To receive the list of papers covered, please fill this form: --------> https://forms.gle/CVVbznAFM8pamdgk6 ------- or by tweeting at us: @AMiNDR_podcast ------------------------------------------------------------------ We would appreciate your fee...2020-11-0938 min
AMiNDR: A Month in Neurodegenerative Disease Research44 - Preclinical Testing Part 2: Alzheimer's Disease August 2020You'll hear about some big topics in Alzheimer's disease research in this episode! Ellen covers all of the pre-clinical studies from August 2020 testing potential new treatments targeting neuroinflammation, oxidative stress, mitochondria, metabolism, and lipids. This is the second part of three pre-clinical testing episodes this month, check out episode #42 for part 1, and look out for part 3, coming soon!------------------------------------------------------------------ To receive the list of papers covered, please fill this form: --------> https://forms.gle/CVVbznAFM8pamdgk6 ------- or by tweeting at us: @AMiNDR_podcast ------------------------------------------------------------------ We would appreci...2020-11-0936 min
AMiNDR: A Month in Neurodegenerative Disease Research43 - Imaging Tools for Diagnosis Part 1: Alzheimer's Disease August 2020Bhumika updates you on the new papers that use brain imaging to diagnose and study AD, in the first of two episodes on this topic! This includes new advances in MRI and PET imaging, and machine learning approaches. You'll hear about studies that looked at changes to functional connectivity, cortical thickness, and other neurological changes in AD, as well as new and improved methods to analyze brain imaging data. Stay tuned for more in Part 2 -- coming out on Sunday, Nov 8! ------------------------------------------------------------------ To receive the list of papers covered, please fill this form: ...2020-11-0616 min
AMiNDR: A Month in Neurodegenerative Disease Research42 - Preclinical Testing Part 1: Alzheimer's Disease August 2020In Part 1 of the AD preclinical testing papers published in August 2020, Naila gets us started with some treatments that target the cholinergic system and synaptic function, tau phosphorylation and resulting pathology, and amyloid-beta mediated toxicity. Given these are some of the hallmarks of AD pathology, trying to prevent or reverse their effects could lead to promising therapeutic outcomes, which these papers first explore in animal models. Naila will also go over a couple miscellaneous — but equally interesting — papers, so stay tuned till the end! ------------------------------------------------------------------ To receive the list of papers covered, please fill this form...2020-11-0626 min
AMiNDR: A Month in Neurodegenerative Disease Research41 - Neuroinflammation & Glial cells: Alzheimer's Disease August 2020Heather covers papers from August 2020 on the role of neuroinflammation and glial cells on Alzheimer's disease pathology. You'll hear about many papers studying the role of astrocytes and microglia in AD pathology, including how they interact with cell signalling pathways and AD-associated proteins such as amyloid and tau. She ends with a couple papers that aim to understand and/or model neuroinflammation in this disease. We hope you enjoy this episode of AMiNDR! ------------------------------------------------------------------ To receive the list of papers covered, please fill this form: --------> https://forms.gle/CVVbznAFM8pamdgk6 ------- or b...2020-11-0628 min
AMiNDR: A Month in Neurodegenerative Disease Research40 - Risk Factors for AD Part 3: Alzheimer's Disease August 2020In Part 3 of the August 2020 Risk Factors episodes, Naila will take you through research on how education and other cognitive factors can influence cognitive decline in later life, tell you about the positive effects of social and family support systems, and discuss papers that examine multiple risk factors at once, in an attempt to get a more complete picture of the complex genetic and environmental interactions that cause AD. She will end with a couple miscellaneous papers that didn’t fit into our sub-themes. Enjoy! ------------------------------------------------------------------ To receive the list of papers covered, please fill this...2020-11-0440 min
AMiNDR: A Month in Neurodegenerative Disease Research39 - Detecting Amyloid & Tau in the Brain Part 1: Alzheimer's Disease August 2020Judy is here to update you on the latest research on detecting amyloid and tau in the brain to diagnose AD in living patients, or to detect AD in post-mortem brain tissue. This includes papers from August 2020 on the latest advances in PET and MRI imaging to detect these proteins, new tracers, and even a few papers on how amyloid and tau pathology may relate to cognitive decline and sex differences in AD. Enjoy! ------------------------------------------------------------------ To receive the list of papers covered, please fill this form: --------> https://forms.gle/CVVbznAFM8pamdgk6 ------- or...2020-11-0419 min
AMiNDR: A Month in Neurodegenerative Disease Research38 - Risk Factors for AD Part 2: Alzheimer's Disease August 2020In part 2 of our Risk Factors episodes for August 2020, Naila will go over papers on comorbidities associated with AD, hormonal factors that may explain some of the sex differences in AD risk, and how sleep relates to various aspects of AD. You’ll learn about various approaches to determining AD risk and prevalence in humans, and will also get a view of how the mechanisms of risk factors are studied in animal models. We hope you enjoy! ------------------------------------------------------------------ To receive the list of papers covered, please fill this form: --------> https://forms.gle/CVVbzn...2020-11-0236 min
AMiNDR: A Month in Neurodegenerative Disease Research37 - Cognitive Changes: Alzheimer's Disease August 2020Anusha updates you on the papers from August 2020 studying cognitive and behavioural changes that occur in Alzheimer's disease and how they relate to disease mechanisms and pathology. This includes research looking at people with AD or mild cognitive impairment, as well as animal models of this disease. Tune in to hear about all this interesting new research! ------------------------------------------------------------------ To receive the list of papers covered, please fill this form: --------> https://forms.gle/CVVbznAFM8pamdgk6 ------- or by tweeting at us: @AMiNDR_podcast ------------------------------------------------------------------ We would appreciate your fee...2020-11-0225 min
AMiNDR: A Month in Neurodegenerative Disease Research37 - Risk Factors for AD Part 2: Alzheimer's Disease August 2020In part 2 of our Risk Factors episodes for August 2020, Naila will go over papers on comorbidities associated with AD, hormonal factors that may explain some of the sex differences in AD risk, and how sleep relates to various aspects of AD. You’ll learn about various approaches to determining AD risk and prevalence in humans, and will also get a view of how the mechanisms of risk factors are studied in animal models. We hope you enjoy! ------------------------------------------------------------------ To receive the list of papers covered, please fill this form: --------> https://forms.gle/CVVbzn...2020-11-0236 min
AMiNDR: A Month in Neurodegenerative Disease Research36 - Synaptic Transmission & Sex Differences: Alzheimer's Disease August 2020Anusha is here to tell you about papers published in August 2020 on a range of topics in synaptic transmission, including changes to cholinergic signalling, glutamate signalling, synaptic plasticity, and connectivity in the context of AD. As well, she ends with a few papers that investigate sex differences in AD, which is very important in the context of studying disease mechanisms and developing effective treatments for both sexes. We hope you enjoy this episode! ------------------------------------------------------------------ To receive the list of papers covered, please fill this form: --------> https://forms.gle/CVVbznAFM8pamdgk6 ------- or b...2020-10-2921 min
AMiNDR: A Month in Neurodegenerative Disease Research35 - Risk Factors for AD Part 1: Alzheimer's Disease August 2020Naila kicks off the August 2020 series of AMiNDR! This is part 1 of 3 of our episodes covering papers from this past August on risk factors for Alzheimer's disease. This includes the latest research on factors such as diet, weight, obesity, diabetes, and vascular disease, and how they may impact the risk of AD and memory decline. Enjoy this episode, and look out for many more coming out soon on this topic and more! ------------------------------------------------------------------ To receive the list of papers covered, please fill this form: --------> https://forms.gle/CVVbznAFM8pamdgk6 ------- or by...2020-10-2635 min
AMiNDR: A Month in Neurodegenerative Disease Research34 - Detecting Amyloid & Tau in the brain: Alzheimer's Disease June 2020Having trouble keeping up with the literature in Alzheimer's Disease? We are here to help! Ellen tells you about the papers on amyloid and tau detection in the brain, from June 2020! This includes studies on PET imaging in humans, PET and MRI imaging in animals, developing fluorescent and antibody probes, and more! Very interesting stuff, we hope you enjoy. This episode finishes off our series covering the papers in June 2020! ------------------------------------------------------------------ To receive the list of papers covered (with timestamps), please fill this form: --------> https://forms.gle/CVVbznAFM8pamdgk6 ------- or...2020-10-1923 min
AMiNDR: A Month in Neurodegenerative Disease Research33 - More on Biomarkers in Alzheimer's Disease June 2020Having trouble keeping up with the literature in Alzheimer's Disease? We are here to help! In this episode, Sarah covers a wide array of papers on biomarkers in AD! You may have listened to our other episodes on this topic (blood and CSF biomarkers). This one gathers the papers that did not fit in those categories, and you're in for a treat: TDP-43, C-reactive protein, epoxide hydrolase, cholinesterase activity, lipids, and more!Enjoy.------------------------------------------------------------------ To receive the list of papers covered (with timestamps), please fill this form: --------> https://forms...2020-10-1838 min
AMiNDR: A Month in Neurodegenerative Disease Research32 - CSF & Mixed Biomarkers: Alzheimer's Disease June 2020Having trouble keeping up with the literature in Alzheimer's Disease? We are here to help! Elyn is back to cover other fluid biomarkers found in the CSF in AD, as well as biomarkers found elsewhere! You will hear about neurofilament light, hormones, synaptic markers, staging MCI... Some papers on imaging also somehow made it here (surprise). Enjoy the episode and keep your eye out for more biomarker episodes coming very soon! ------------------------------------------------------------------ To receive the list of papers covered (with timestamps), please fill this form: --------> https://forms.gle/CVVbzn...2020-10-1737 min
AMiNDR: A Month in Neurodegenerative Disease Research31 - Blood Biomarkers: Alzheimer's Disease June 2020Having trouble keeping up with the literature in Alzheimer's Disease? We are here to help! Elyn tells you about papers on blood biomarkers for AD in this episode of AMiNDR! This includes a range of topics, including RNA biomarkers, neurofilament light, proteins biomarkers, and more! All of the papers are from June, 2020. Enjoy the episode and keep your eye out for more biomarker episodes coming very soon! ------------------------------------------------------------------ To receive the list of papers covered (with timestamps), please fill this form: --------> https://forms.gle/CVVbznAFM8pamdgk6 ------- or by tweet...2020-10-1247 min
AMiNDR: A Month in Neurodegenerative Disease Research30 - Imaging Tools for Diagnosis Part 2: Alzheimer's Disease June 2020Having trouble keeping up with the literature in Alzheimer's Disease? We are here to help! In part 2, Bhumika tells you all about the new papers on imaging tools for AD from June 2020! You'll hear more about studies on using imaging technology such as MRI and PET to diagnose AD. If this is a topic that interests you, check out part 1 as well! ------------------------------------------------------------------ To receive the list of papers covered (with timestamps), please fill this form: --------> https://forms.gle/CVVbznAFM8pamdgk6 ------- or by tweeting at us: @AMiNDR_podcast...2020-10-0830 min
AMiNDR: A Month in Neurodegenerative Disease Research29 - Amyloid-beta-mediated toxicity: Alzheimer's disease June 2020Having trouble keeping up with the literature in Alzheimer's Disease? We are here to help! Sarah has a lot of fun hosting this highly interesting episode covering papers published in June 2020 on amyloid-beta-mediated toxicity in AD! We hope you enjoy, and that this update is useful for your research! If you're interested in papers on other mechanisms of amyloid-beta pathology in AD, check out episode #13 on APP processing and amyloid-beta aggregation. To receive the list of papers covered (with timestamps), please fill this form: --------> https://forms.gle/CVVbznAFM8pamdgk6 ------- or by...2020-10-0322 min
AMiNDR: A Month in Neurodegenerative Disease Research28 - Imaging Tools for Diagnosis Part 1: Alzheimer's Disease June 2020Having trouble keeping up with the literature in Alzheimer's Disease? We are here to help! Bhumika tells you all about the new papers on imaging tools for AD from June 2020! You'll hear about tools for the prediction of disease progression, the classification of AD, and the initial diagnosis of AD. New machine learning and bioinformatics tools for AD research and diagnosis are also covered in this episode. This is only part 1, stay tuned for part 2, coming out soon! To receive the list of papers covered (with timestamps), please fill this form: --------> https://forms...2020-09-2833 min
AMiNDR: A Month in Neurodegenerative Disease Research27 - Novel Drug Development - Part 4: Alzheimer's Disease June 2020Having trouble keeping up with the literature in Alzheimer's Disease? We are here to help! Joseph tells you about more papers on drugs in development from June 2020. These studies encompass those done in vitro or using computational models, but not animal testing. This episode brings together abstracts that were not sorted into a specific target cluster, so you will hear about a variety of treatment targets such as histone deacetylase, caspase-6, monoamine oxidase, microRNA, and more! To receive the list of papers covered (with timestamps), please fill this form: --------> https://forms...2020-09-2522 min
AMiNDR: A Month in Neurodegenerative Disease Research26 - Refining and Repurposing Treatments: Alzheimer's Disease June 2020Having trouble keeping up with the literature in Alzheimer's Disease? We are here to help! In this episode, Sarah updates you on the papers from June 2020 that aim to refine or repurpose drugs and other treatments for Alzheimer's disease! This includes studies on refining existing AD treatments, refining the method of delivery, and repurposing non-AD drugs for use in AD treatment. If you're interested in learning more about research on AD treatments, you should also check out our episodes on novel drug development, pre-clinical and clinical testing. Enjoy today's episode! To receive the list...2020-09-2156 min
AMiNDR: A Month in Neurodegenerative Disease ResearchNovel Drug Development-Part 3: Alzheimer's Disease June 2020Having trouble keeping up with the literature in Alzheimer's Disease? We are here to help! Joseph tells you about more papers on drugs in development from June 2020. These studies encompass those done in vitro or using computational models, but not animal testing. Here, you will hear about approaches with multiple targets: cholinesterase, amyloid-beta, tau, oxidative stress... If you're interested in hearing more about treatments for AD, you should also check out our episodes on pre-clinical and clinical testing. To receive the list of papers covered (with timestamps), please fill this form: ...2020-09-1821 min
AMiNDR: A Month in Neurodegenerative Disease ResearchNovel Drug Development-Part 2: Alzheimer's Disease June 2020Having trouble keeping up with the literature in Alzheimer's Disease? We are here to help! Ellen tells you about more papers on drugs in development from June 2020. These studies encompass those done in vitro or using computational models, but not animal testing. This time around, she will be focusing on papers where the target is tau protein, the cholinergic system, metabolism, mitochondria, neuroinflammation, and autophagy from June 2020! If you're interested in hearing more about treatments for AD, you should also check out our episodes on pre-clinical and clinical testing. To receive the list of p...2020-09-1333 min
AMiNDR: A Month in Neurodegenerative Disease ResearchNovel Drugs Targeting Amyloid-Beta: Alzheimer's Disease June 2020Having trouble keeping up with the literature in Alzheimer's Disease? We are here to help! Ellen tells you about papers on drugs in development targeting amyloid-beta production, aggregation, and toxicity from June 2020! If you're interested in hearing more about treatments for AD, you should also check out our episodes on pre-clinical and clinical testing. To receive the list of papers covered (with timestamps), please fill this form: --------> https://forms.gle/CVVbznAFM8pamdgk6 ------- or by tweeting at us: @AMiNDR_podcast -----------------------------------------------------------------------List of sections in this episode: ...2020-09-0941 min
AMiNDR: A Month in Neurodegenerative Disease ResearchPreclinical Testing - Part 3: Alzheimer's Disease June 2020Having trouble keeping up with the literature in Alzheimer's Disease? We are here to help!In this episode, Marcia covers papers published in June 2020 on treatment development done on animal models, targeting metabolism, mitochondria, oxidative stress, the gut microbiome, inflammatory pathways, glia, and autophagy. If you are interested in learning more about these pathological events, you should check out our episode on these disease mechanisms, covered by Anusha. We also have a number of episodes dedicated to pre-clinical testing, split by the intended target the cholinergic system, the glutamatergic system, synaptic function, tau, amyloid-beta, cognitive performance, and...2020-09-0532 min
AMiNDR: A Month in Neurodegenerative Disease ResearchPreclinical Testing - Part 2: Alzheimer's Disease June 2020Having trouble keeping up with the literature in Alzheimer's Disease? We are here to help!In this episode, Naila covers papers published in June 2020 on treatment development done on animal models, targeting the cholinergic system, the glutamatergic system, synaptic function, tau, and amyloid-beta. If you are interested in this topic, you should check out our other episodes on this topic from the same month, where the approach targeted oxidative stress, inflammation, autophagy, cognitive function...Enjoy! To receive the list of papers covered (with timestamps), please fill this form: --------> https://for...2020-09-0143 min
AMiNDR: A Month in Neurodegenerative Disease ResearchClinical Testing: Alzheimer's Disease June 2020Having trouble keeping up with the literature in Alzheimer's Disease? We are here to help! In this episode, Joseph presents papers published in June 2020 where pharmacological approaches and new compounds are tested on humans. You will hear about intranasal insulin, probiotics, Diclofenac, Crenezumab, and more. If you are interested in this topic, you can also check our episodes on pre-clinical testing, which encompass studies done on animals. We are also working on an episode focused on repurposing and refining existing drugs, coming out soon. Enjoy! To receive the list of papers covered (with time...2020-09-0117 min
AMiNDR: A Month in Neurodegenerative Disease ResearchGenetic Landscape Part 2: Alzheimer's Disease June 2020Having trouble keeping up with the literature in Alzheimer's Disease? We are here to help! This episode is the second of two parts on the genetic landscape of AD! Here, Marcia will tell you about papers published this past June on sex differences, DNA methylation, some on transcriptomic, and more. Enjoy! To receive the list of papers covered (with timestamps), please fill this form: -------> https://forms.gle/CVVbznAFM8pamdgk6 ------- or by tweeting at us: @AMiNDR_podcast -------------------------------------------------------------------- List...2020-08-3133 min
AMiNDR: A Month in Neurodegenerative Disease ResearchGenetic Landscape Part 1: Alzheimer's Disease June 2020Having trouble keeping up with the literature in Alzheimer's Disease? We are here to help! This episode is the first of two parts on the genetic landscape of AD! Here, Marcia will tell you about papers published this past June on the well-known AD-related genes PSEN-1 and APOE, as well as amyloid-beta related mutations, novel variants, and other variants/mutations. Enjoy! To receive the list of papers covered (with timestamps), please fill this form: -------> https://forms.gle/CVVbznAFM8pamdgk6 ------- or by tweeting at us: @AMiNDR_podcas...2020-08-2830 min
AMiNDR: A Month in Neurodegenerative Disease ResearchCerebrovascular Changes & Unclassified Disease Mechanisms: Alzheimer's Disease June 2020Having trouble keeping up with the literature in Alzheimer's Disease? We are here to help! Elyn will tell you all about papers from June 2020 on cerebrovascular changes and unclassified disease mechanisms in AD. We hope you enjoy! To receive the list of papers covered (with timestamps), please fill this form: -------> https://forms.gle/CVVbznAFM8pamdgk6 ------- or by tweeting at us: @AMiNDR_podcast -------------------------------------------------------------------- List of sections in this episode: Cerebral amy...2020-08-2438 min
AMiNDR: A Month in Neurodegenerative Disease ResearchNon-Pharmacological Treatment Approaches: Alzheimer's Disease June 2020Having trouble keeping up with the literature in Alzheimer's Disease? We are here to help! In this episode, Naila will tell you about topics including intermittent fasting, musical interventions, young plasma treatment, and... hairy garlic, to name a few! She covers the papers in June 2020 that came out on non-pharmacological approaches for AD treatment. Enjoy the episode and feel free to reach out to let us know what you think of these interesting approaches! To receive the list of papers covered (with timestamps), please fill this form: ...2020-08-2245 min
AMiNDR: A Month in Neurodegenerative Disease ResearchMetabolism, Mitochondrial (Dys)function, Oxidative Stress, Autophagy, & Gut Microbiome: Alzheimer's Disease June 2020Having trouble keeping up with the literature in Alzheimer's Disease? We are here to help!In this episode, Anusha combines different topics pertaining to disease mechanisms in Alzheimer's Disease, starting with metabolic changes, then zooming in on mitochondria, and oxidative stress. Last, she covers the publications on autophagy and the gut microbiome, and how their involvement in Alzheimer's pathology. These papers were all published in June 2020. We hope you find this podcast enjoyable, accessible and useful for your work! To receive the list of papers covered (with timestamps), please fill this form: ...2020-08-2035 min
AMiNDR: A Month in Neurodegenerative Disease ResearchTau & Other Protein Related Pathologies: Alzheimer's Disease June 2020Having trouble keeping up with the literature in Alzheimer's Disease? We are here to help!In this episode, Naila goes over the papers from June 2020 on Tau aggregation & phosphorylation as pertaining to Alzheimer's Disease. She then moves on to general protein aggregation (if you are interested in Amyloid-beta specifically, that one's got a whole episode on its own) and protein uptake and trafficking. Enjoy!To receive the list of papers covered (with timestamps), please fill this form: -------> https://forms.gle/CVVbznAFM8pamdgk6 -------or by tweeting at us: @AMiNDR_podcast2020-08-1953 min
AMiNDR: A Month in Neurodegenerative Disease ResearchAPP Processing & Amyloid-beta aggregation: Alzheimer's Disease June 2020Having trouble keeping up with the literature in Alzheimer's Disease? We are here to help!In this episode, Sarah gives an overview on the papers on APP processing, then presents the latest findings on Amyloid-beta aggregation. If you are interested in Amyloid-mediated pathology in Alzheimer's disease, stay tuned for the episode dedicated to that topic. Enjoy!To receive the list of papers covered (with timestamps), please fill this form: -------> https://forms.gle/CVVbznAFM8pamdgk6 -------or by tweeting at us: @AMiNDR_podcast--------------------------------------------------------------------List of sections in t...2020-08-1848 min
AMiNDR: A Month in Neurodegenerative Disease ResearchCognitive/Behavioural Testing & Unclassified Detection Methods: Alzheimer's Disease June 2020Having trouble keeping up with the literature in Alzheimer's Disease? We are here to help! In this episode, Ellen starts by updating you on the latest papers on cognitive and behavioural testing for the detection or diagnosis of AD. Then, she moves on to papers we sorted under Unclassified Detection methods. Enjoy!To receive the list of papers covered (with timestamps), please fill this form: -------> https://forms.gle/CVVbznAFM8pamdgk6 -------or by tweeting at us: @AMiNDR_podcast--------------------------------------------------------------------List of sections in this epis...2020-08-1242 min
AMiNDR: A Month in Neurodegenerative Disease ResearchNeuroinflammation & Glial Cells: Alzheimer's Disease June 2020Having trouble keeping up with the literature in Alzheimer's Disease? We are here to help! Sarah will tell you about the AD papers from June 2020 on some of her favourite topics: neuroinflammation and glial cells! To receive the list of papers covered (with timestamps), please fill this form: -------> https://forms.gle/CVVbznAFM8pamdgk6 -------or by tweeting at us: @AMiNDR_podcast--------------------------------------------------------------------List of sections in this episode: Multitargeted Approaches & Neuroprotective Compounds (1.16)Improving Cognition (16.04)--------------------------------------------------------------------We would appreciate your feedback so we can bet...2020-08-0852 min
AMiNDR: A Month in Neurodegenerative Disease ResearchPreclinical Testing - Multi-targeted approaches and Improving Cognition: Alzheimer's Disease June 2020Having trouble keeping up with the literature in Alzheimer's Disease? We are here to help!In this episode, Anusha first covers papers on preclinical testing of multi-targeted approaches for AD treatment, followed by papers on preclinical testing to improve cognition. Enjoy!To receive the list of papers covered (with timestamps), please fill this form: --------> https://forms.gle/CVVbznAFM8pamdgk6 -------or by tweeting at us: @AMiNDR_podcast-----------------------------------------------------------------------List of sections in this episode: Multitargeted Approaches & Neuroprotective Compounds (1.16)Improving Cognition (16.04)-----------------------------------------------------------------------We would...2020-08-0627 min
AMiNDR: A Month in Neurodegenerative Disease ResearchModifiable Risk Factors: Alzheimer's Disease June 2020 (Part 2)Having trouble keeping up with the literature in Alzheimer's Disease? We are here to help! You'll hear more from Naila in this episode on the papers published in June 2020 on modifiable risk factors in AD. This includes lifestyle and comorbidities. Enjoy!To receive the list of papers covered (with timestamps), please subscribe to our mailing list. You can do so by filling this form: --------> https://forms.gle/CVVbznAFM8pamdgk6 -------or by sending us an email at ---------> amindrpodcast@gmail.com-----------------------------------------------------------------------List of sections i...2020-08-0327 min
AMiNDR: A Month in Neurodegenerative Disease ResearchModifiable Risk Factors: Alzheimer's Disease June 2020 (Part 1)Having trouble keeping up with the literature in Alzheimer's Disease? We are here to help! This is the first of a two-part episode, where Naila covers the papers published in June 2020 on modifiable risk factors in AD, namely: cognitive reserve, diet, comorbidities, sleep, ... Stay tuned for the second part!To receive the list of papers covered (with timestamps), please subscribe to our mailing list. You can do so by filling this form: --------> https://forms.gle/CVVbznAFM8pamdgk6 -------or by sending us an email at ---------> amindrpodcast@gmail.com2020-08-0152 min
AMiNDR: A Month in Neurodegenerative Disease ResearchCognitive Changes & Synaptic Transmission: Alzheimer's Disease June 2020Having trouble keeping up with the literature in Alzheimer's Disease? We are here to help! In this episode, we cover the papers published in June 2020 about cognitive changes and synaptic transmission in Alzheimer's disease. You get 2 for 1! To receive the list of papers covered (with time-stamps), please subscribe to our mailing list. You can do so by filling this form: --------> https://forms.gle/CVVbznAFM8pamdgk6 -------or by sending us an email at ---------> amindrpodcast@gmail.com-----------------------------------------------------------------------List of sections in this episode: Cognitive...2020-07-2923 min
AMiNDR: A Month in Neurodegenerative Disease ResearchTreatment Development in Alzheimer's Disease-February 2020 - Part 2To receive the list of papers covered (with time-stamps), please subscribe to our mailing list. You can do so by filling this form: --------> https://forms.gle/CVVbznAFM8pamdgk6 -------or by sending us an email at ---------> amindrpodcast@gmail.com-----------------------------------------------------------------------List of sections in this episode:Targeting Acetylcholinesterase/the cholinergic system (1.56)Targeting the glutamatergic system (10.13)Targeting tau phosphorylation/tau protein (11.22)Targeting Amyloid-beta mediated toxicity (12.48)Targeting Amyloid-beta production (16.16)Antibody-mediated approaches/immunotherapies (17.43)Targeting inflammatory processes (22.00)Targeting oxidative stress (29.57)Targeting mitochondria (36.28)Targeting metabolism (39.07)Gut microbiota (40.28)Multi-targeted approaches and neuroprotective compo...2020-07-211h 03
AMiNDR: A Month in Neurodegenerative Disease ResearchTreatment Development in Alzheimer's Disease-February 2020- Part 1To receive the list of papers covered (with time-stamps), please subscribe to our mailing list. You can do so by filling this form: --------> https://forms.gle/CVVbznAFM8pamdgk6 -------or by sending us an email at ---------> amindrpodcast@gmail.com-----------------------------------------------------------------------List of sections in this episode:New approaches in drug development (1.45)Drug refinement & repurposing (30.31)Non-pharmacological approaches/behavioral interventions (48.53)In the next episode (part 2), you will hear about pre-clinical testing, which involves papers where at least one experiment was conducted on animals. -----------------------------------------------------------------------This...2020-07-171h 00
AMiNDR: A Month in Neurodegenerative Disease ResearchGenetics, Risk Factors & New diagnostic tools_AD_Papers published in February 2020To receive the list of papers covered (with time-stamps), please subscribe to our mailing list. You can do so by filling this form: --------> https://forms.gle/CVVbznAFM8pamdgk6 -------or by sending us an email at ---------> amindrpodcast@gmail.com-----------------------------------------------------------------------List of sections in this episode: 1. Genetic landscape (1.43)2. Modifiable risk factors (27.13)3. Diagnostic methods (58.24) -----------------------------------------------------------------------This episode was curated and produced by a group of volunteers. As we work on producing full-length episodes on ALL the p...2020-06-291h 37
AMiNDR: A Month in Neurodegenerative Disease ResearchPapers published on Alzheimer's disease in February 2020: Methods & ModelsAbout the bibliography: To receive the list of papers covered (with time-stamps), please subscribe to our mailing list. You can do so by filling this form: https://forms.gle/jJM9dK4SufapQkey8 or by sending us an email at amindrpodcast@gmail.com List of sections in this episode: Lab techniques (1.35)New animal models (19.32)Old animal models (27.16)New cellular models (28.27)Tissue engineering (32.42)Human methodology (34.14)Computational modeling (47.48) This episode was curated and produced by a group of volunteers. As we work on producing full-length episodes on ALL...2020-06-161h 05
AMiNDR: A Month in Neurodegenerative Disease ResearchPapers published on Alzheimer's disease in February 2020: Disease MechanismsAbout the bibliography: To receive the list of papers covered (with time-stamps), please subscribe to our mailing list. You can do so by filling this form: https://forms.gle/jJM9dK4SufapQkey8 or by sending us an email at amindrpodcast@gmail.com List of sections in this episode: (1.09) Neuroinflammation/glial cells(14.40) Protein aggregation and post-translation modification (eg: phosphorylation, misfolding), protein-protein interactions(33.31) Cell metabolism (mitochondrial dysfunction, lipids, hormones)(39.00) Neuronal plasticity : cell proliferation, differentiation, maturation, survival + cell death + survival/protection(42.11) Cerebrovascular changes(45.49) Synaptic Transmission(54.33) Autophagy This e...2020-06-0859 min
AMiNDR: A Month in Neurodegenerative Disease ResearchWelcome to AMiNDR!Do you have feedback? Suggestions? Please take a few minutes to fill our survey, so we can better refine our platform: https://forms.gle/RzZcaEMHuqj4awhh8Interested in joining the team? Get in touch with us! We are specifically looking for people who can help develop content (write summaries and sort papers), but also welcome individuals who want to contribute in other ways.You can subscribe to receiving the bibliography for each episode, by sending us an email at: amindrpodcast@gmail.comAre you on twitter? Give us a shout: @AMiNDR_podcast...2020-06-0834 min