Shows
The Effective Statistician - in association with PSIInnovation, play and failingInterview with Mike Smith
Mike and I discuss innovation and the different factors that affect it. We specifally mention the following points:
Time is equally valuableMake time to playBe curiousPlay with purposeCulture effectSay 'yes' to opportunitiesLook for supportive managersDelivery is more importantFailureFail early. Fail often.Blameless post -mortemCommunicationBuild relationships
Listen to this podcast and share this with your friends and colleagues!
2020-09-2146 minThe Effective Statistician - in association with PSI10 reasons for career failure and what you can do about it
Here are some major causes of failure:
Lack of Ambition to Aim Above MediocritySetting exciting goals, thinking biggerLack of Self-DisciplineKnow what motivates you Ill HealthSleep, exercise and foodProcrastinationWaiting for more data, better time, other circumstances Lack of PersistenceNot closing loops, follow upLack of a Well Defined Power of DecisionBias to action and acceptance of not all information available Lack of Concentration of EffortToo many things going onCombination of tasksRepurposing Repeating Lack of EnthusiasmPassion and interest starts often with going deep IntoleranceOpen and curious Inability to Cooperate With OthersOnly teams achieve big results Delegation Leadership
Reference:
https...2020-09-1522 minThe Effective Statistician - in association with PSI4 steps to engage successfully with senior stakeholders and committees
AnticipateBe clear on your goalsWhere is the stakeholder nowPrepare slides and review these from the audience perspectiveCreate potentially a pre-read ActivateSet the expectations for the meetingCreate a common objective depending on what the interest of the stakeholders areEngageAvoid too long monologuesRemove distractions for all participantsGet the participants to do somethingRemind about your key pointsAnticipate roadblocks and critiqueActionClarify and ask questionsGet feedbackAmplify key messagesHave a specific call to actionsNext steps
Listen to this episode now and share this with your friends and colleagues who might learn from it!
2020-09-0720 minThe Effective Statistician - in association with PSIJust being brilliant at stats doesn’t bring you far
Being brilliant at stats is really important, but it is not the only thing one must be good at. In this episode, I talk about my good and bad experiences and discuss what we can learn from them. I also discuss the following points:
What you must do if you are:
Not being understood Working on irrelevant things Getting into big arguments and losing themNot being able to appropriately pushing backGetting a bad reputation Getting a bad rating Becoming frustrated and unmotivated
The solution for many of these topics is becoming a better leader...2020-08-3124 minThe Effective Statistician - in association with PSIMy personal leadership principles
I will be talking about these interesting points:
Why personal leadership principles are important?
Reflect on who you want to beRemind you to hold yourself accountableHelp you focus on your learningBe aware of the flip sides of these
My personal leadership principles:
Exerting a bias toward action and taking calculated risks (entrepreneurship, performance)Striving for sustainability and balancing family and work (care and performance)Building trust and listening first (integrity and accountability) and then be accountable and demand accountability Always consider delegation firstContinuously learn and innovateEmbodying a positive attitude
Listen and learn from...2020-08-2518 minThe Effective Statistician - in association with PSIMy personal lessons from using various data visualizations
These kinds of visualization helped me a lot to open new doors and made me amazingly easy to stand out from other statisticians. In this episode, I am sharing the following points:
Visualization help you sell your workEasily understandableEasy to stand outIs fun to createLots of opportunities beyond our usual graphsShowing the variabilityShowing the individual patientsScatterplotsLine graphsHeatmapsCumulative distribution functionsHistograms or fitted density functionsAnimations to show changes over timeInteractivity to showcase subgroups or different endpointsProduce multiple graphs at once for different audiences and documents
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2020-08-1823 minThe Effective Statistician - in association with PSIHow to run effective meetings, even if you are just a participant
In this episode, I talk about the important questions that we need to answer and the points we need to consider to ensure an effective meeting. Here are the steps you can follow and what can you do if these steps are not followed in a meeting you’re invited to:
What is the goal you want to achieve?Do you need a meeting at all?Who is really needed for the meeting?Who will contribute?Who could derail the outcome?Who would you need as an ally potentially?How long do you need the meeting to be?Ad...2020-08-1143 minThe Effective Statistician - in association with PSIEverything you need to know about matching adjusted indirect comparisonsAn Interview with Daniel Saure
In today's episode, Daniel and I talk about these questions and discuss more about the following points:
Bucher vs MAIC - advantages and disadvantagesMethodik MAICNICE technical document (http://nicedsu.org.uk/technical-support-documents/population-adjusted-indirect-comparisons-maic-and-stc/) - including R codeWhich baseline variables to include?What to do if you have multiple studies on one side?patient-level data meta-analysesliterature studies meta-analysesHow to compute the “average” baseline variables?How to adjust for baseline variables?What are the different ways to adjust? (https://www.ncbi.nlm.nih.gov/pubmed/30661638)How does it relate to network meta-analyses
Reference: Case stud...2020-08-0442 minThe Effective Statistician - in association with PSIThe future of safety analyses: interactivity, visualizations and the FDAInterview with Wei Wang
In today's episode, Wei and I dive deep into the future of safety analyses and discuss the following topics:
For interactive tools - how can we achieve traceability of what we looked at demonstrating transparency on the decision process in an interactive tool?What are your experiences in developing an interactive tool?What are the best practices for data visualizations for safety?How can we give external parties like the FDA access to such tools?
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2020-07-2844 minThe Effective Statistician - in association with PSIHow to play the game of business to build stronger, more innovative, more inspiring organizationsInterview with Stuart McGuire - VERAMED Episode
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Stuart and I talk about the following:
Simon Sinek's latest book speaks about “the infinite game” - What is your take on this and how do you see this applying to our industry?Do you have any examples, where this has helped our industry moving forward?What behaviours do you see, which correspond to a finite game mindset and which limits us from achieving what we could achieve?What can we do personally to adopt an infinite game mind...2020-07-2039 minThe Effective Statistician - in association with PSIHave you ever considered a career outside of statistics?Learn from Lucy Rowell
We also talk about the following points:
You started as a statistician in your career, but then you got further responsibilities. How did this happen?How has your knowledge as a statistician helped you to be successful in your new roles?Which things did you need to learn new?What does leadership mean for you personally?Do you have a story where you struggled in terms of your leadership skills and how you grew out of it?When do you think is the right time to switch into a career outside of statistics?Which...2020-07-1344 minThe Effective Statistician - in association with PSIPlotting your career and preparing the terrainInterview with Diana Stuart
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We also debate these important points:
Ways to work with your line managerEmbrace changeGreat self-awareness about your strengths and limitations and about how they change over time (technical and non-technical skills)Create networks to ensure being invited into opportunities: create exposureMotivation (mastery, purpose, autonomy) is key for long-term successConstantly invest in yourself and own your self-management
Listen to this episode and learn more!
2020-07-061h 11The Effective Statistician - in association with PSI3 Time management hacks, that actually work
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In today's episode, Benjamin and I talk about different time management hacks to be productive and efficient while working at home. We also talk about these following important points:
Things you should first establish:
Be clear on your goals and keep them in front of youFocus on building great habits as these will carry you to success
Three time management hacks:
Saying no and turning things back - reflect workFocus your efforts and concentration (schedule time, manage distractions)Get and stay...2020-06-2934 minThe Effective Statistician - in association with PSIThe Story of Veramed - love and statisticsInterview with Emma and Matt Jones
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If your answer is yes, I am sure that you'll be very interested to hear the story of Matthew and Emma as they will be sharing today their experience on how they started their own company, Veramed, in 2012 after having their established careers working in the industry for both large pharma and CROs.
We also talk about the following points:
What is the founding story of Veramed?Why did you start it in early 2012 after being a...2020-06-2242 minThe Effective Statistician - in association with PSI8 steps to make a smart decision
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In today's episode, we discuss how to manage problems with efficiency, clarity, logic, consistency, alignment, and speed. Also, the 8 steps to make a smart decision :
ProblemObjectivesAlternativesConsequencesTradeoffsUncertaintyRisk ToleranceןLinked Decisions
Listen to this episode and learn from it!
2020-06-1542 minThe Effective Statistician - in association with PSIPresent like a pro14 presentation tips
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In today's episode, Benjamin and I discuss the 14 presentation tips that really work. We speak about:
Be clear on your goals Have a strong startStart with a story, conclusions, then introduce yourself Enter the room or stage with confidence Story on GBA training Speak to Ethos, Pathos and LogosEstablish a powerful position Make eye contact Smile Never lean back when sitting - better stand upDress appropriately Avoid anything distracting Appear confident Position your cameraUse pauses intentionally Variation of the voice Loud and softPitchSpeedUse...2020-06-0851 minThe Effective Statistician - in association with PSIFailed study, new safety finding, mistakes - breaking bad news
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In today's episode, Benjamin and I discuss about the following points:
First mover advantagePreparing and planningBe clear on your goalsWho do you want to move from A to B What questions will come up? What will be our replies? What will be the follow-up questions?Who will be affected?Who needs/must know first?How do you communicate it?
How to break the bad news:
Tell it allTell it fastTell them what you’re doing about itTell them, when it’s overGet back to wo...2020-06-0127 minThe Effective Statistician - in association with PSIHow to create win-win situations?Interview with Justine Rochon
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Today, we are talking about so-called win-win situations. Win-win is a situation that has the potential to be beneficial to all involved. Justine and I also discuss the following points:
Examples of career driversThe roles of to help your progress?Many larger pharma companies have technical tracks and management tracks. What skills help statisticians move forward on both these tracks?What common problems hinder statisticians progressing in their careers and how to overcome or avoid these?
Listen to this...2020-05-2546 minThe Effective Statistician - in association with PSIWorking long hours – is it worth it?Interview with Ian Ratcliffe – IQVIA
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In today's episode, Ian and I discuss working long hours - it's advantages and disadvantages. We also talk about the important points:
Having clear boundaries at workHow to say NOHow to effectively manage your time and expectations
Listen to this episode and share it with others who can learn from it!
2020-05-1831 minThe Effective Statistician - in association with PSIMakeoverMonday – Improving How We Visualise and Analyze DataInterview with Eva Murray and Andy Kriebel
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Today, I talk with these two awesome visualization experts - Eva and Andy. They have written great content about data analysis and visualization. Learn a lot about great visualizations from them. We discuss the following important points:
How to create effective visualizationsHow to communicate this dataHow do people benefit from it
References:MakeoverMondayWhat's Going on in this GraphChart Guide
Listen to these awesome data visualization experts and learn from...2020-05-1148 minThe Effective Statistician - in association with PSICore Outcome Measures in Effectiveness Trials - COMETAn interview with Paula Willamson and Liz Gargon
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This clarifies directly what the COMET initiative is about. But it also leaves open a lot of questions such as:
Why are COS important?What are the goals of COMET?How narrow or how wide should COS be defined?What does the process look like to get to COS?
References:
Homepage of COMETCOMET VIII ConferenceReferences from COMETCOMET DatabaseTwitterCore outcomes set in RA
...2020-05-0444 minThe Effective Statistician - in association with PSIITIT - an acronym which will help you get started in the pharma industry
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In this podcast, we talk about the following 9 important points:
In this podcast, we talk about the following 9 important points:
Overview of the ITIT courseWho is the course aimed atWhat are the reasons to attendHow the course keeps up with changes in the industryWhere does the course fit in with the organization's goalsWhy should a manager think about sending someone from their team on the courseWhich locations delegates can expect to visitWhat makes the course such a successFrom the delegates' perspective, what are...2020-04-2736 minThe Effective Statistician - in association with PSI9 learnings from over 100 episodes over 2 years
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And today, we are looking back and discuss the last 2 year's learnings. We discuss the 9 learnings we had and how they apply to you as a listener as well. Specifically, we talk about:
Think bigger
Prepare for the unexpected
Delegate what you are not good at or what you don’t like
Have fun
Relationships are the foundation for success
Be curious and dig deeper
Our community is big
Unnecessary red tape differs a lot by company
Growth happens outside your comfort zone
We need to a...2020-04-2037 minThe Effective Statistician - in association with PSIWhy and how to declutter and simplify your data visualizationEpisode 3
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In episode 3 of this mini-series, I discuss the impact of simplified data visualization and how to achieve it. Specifically, I address these factors that affect your visualization:
Clutter
2020-04-1322 minThe Effective Statistician - in association with PSIRunning on 2 legsBonus Episode 2 - COVID
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Today, I'm speaking about Running on 2 legs - my call to action for statisticians to step-up in this COVID pandemic.
How can statistician not just reflect on and analyze data, but to lead on letting the people understand the dataShort-term thingLong-term thingLet people understand statisticians' functions and role to societyStatisticians as strategic partners
Enjoy listening to this episode and be more aware on what we can do to add value to this time of pandemic!
2020-04-0822 minThe Effective Statistician - in association with PSICOVID-19 and how charts lieInterview with Alberto Cairo
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We also discuss the following points:
How tables compare to charts in terms of “lying”How to strike the best balance between showing the details and overwhelming the audienceWhat behaviours or habits should we develop to improve our visualizations
References:
References:
Michael Friendly's Golden Age of Visualization paper
Eurostat's Power from Statistics about uncertainty,The story about the "New Golden Age"
Tools:
DataWrapper
Flourish
iNZight
...2020-04-0656 minThe Effective Statistician - in association with PSIGetting to a good visualizationEpisode 2
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In this second episode. I talk about how you can get a good visualization. Here are the following important tips:
Importance of detailsCo-creation with the audienceExample launch slide setKOL engagmentMultiple review roundsTesting and refinementExample trial level safety analysesIterative approach - validation level - documentation - fast turn aroundsStart with pen and paper and develop together fastFocus on the larger topics like which plot to use first and then fine-tune to a more detailed level (examples for each)Use of colourTitleLabels, legendsAlignmentFootnotesSupporting textDashboards (examples of...2020-03-3023 minThe Effective Statistician - in association with PSILearnings from the COVID crisis for statisticians
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I discuss my learnings, my reflection about this, and what is the meaning of this situation for us, statisticians, and more significant factors like the following:
Hardly any tables out there, but lots of visualizations both interactive and explanatory - still most of our day-to-day jobs are providing tablesTables are not the key deliverables episodeInterview with Zak Skrivanek - a figure says more than 1000 tablesWonderful Wednesday episodeVIS SIG Get the data from many different sources - not just the one source at hand: e.g...2020-03-3018 minThe Effective Statistician - in association with PSIWorking from home - is this for you?Interview with Jürgen Hummel
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In this episode, Jürgen and I discuss about the following points:
Why is working from home beneficial for the statistician and the employerWhat tasks are especially suitable for working from homeWhat tips do we have to make working from home successfulHow to balance office time and home office time
Learn more by listening to this episode and share this link with others who might be interested in working at home!
2020-03-2336 minThe Effective Statistician - in association with PSIData visualization - the often overlooked basicsEpisode 1
In today's episode, I review the different things you need to consider in creating an effective data visualization when presenting, which is the following:
Who is the audience?Level of understandingKOLResearcherStatisticiansWhat is the medium?PresentationEmailPaperHow much time do you have?Who is the presenter? Is there one at all?Understand how your visualization is used downstream
References:Storytelling with data - cole nussbaumer knaflicTamara Munzners book Visualization, Analysis and DesignDatastori.esBig book of dashboardsMakeover MondayD3 gallery on githubSpecial interest group VIS...2020-03-1633 minThe Effective Statistician - in association with PSILearnings from Florence NightingaleInterview with Deborah Ashby
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Despite her having a weak position in society at the time - being a nurse and a women – she still was very influential and achieved a lot. Many statisticians feel like they are not part of key decisions and don’t have the impact, they could have. What can we learn from her in this regard?
References:Link to the homepage of the conference keynote speakers
Link to the home page of the conference
List...2020-03-0942 minThe Effective Statistician - in association with PSIProblems for statisticians to take onInterview with Stephen Pyke
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In today's episode, Stephen and I discuss the PSI strategy day in 2019 and focused on the following points:
My own journey - statistics and beyondHoliday reading - people respond to incentivesClinical development - Our main job: minimize value destructionAddressing the challenges of low productivityProblem that needs more attentionTime - Study enrollment time is often an important source of uncertainty in project plansQuality - Detecting site quality issues quickly is criticalCost - Trial costs are more likely to increase than reduceStatistics at...2020-03-0253 minThe Effective Statistician - in association with PSIWonderful WednesdaysInterview with Rachel Phillips and Mark Baillie
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n today's episode, we talk about the advantages of using visualizations when analyzing and communicating data. We also discuss the following points:
In today's episode, we talk about the advantages of using visualizations when analyzing and communicating data. We also discuss the following points:
How our organizations prioritize visualizations?What we love about visualizations?What are the principles of visualization statisticians should know about?How to create interesting, innovative, and purposeful visualizations?
Listen to this...2020-02-2439 minThe Effective Statistician - in association with PSIRWE demystifiedInterview with Imi Dean
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Imi works on such data on a daily basis and I’ve worked on observational studies since 2004. In this podcast episode, we will explain some of these topics, bust some myths and help you to understand how this data fits into the bigger picture.
Listen to this episode and share it with others who might learn from it!
2020-02-171h 28The Effective Statistician - in association with PSIHow and why to increase your external profile!Interview with Liz Cole
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Listen to our conversation and understand:
What is content marketing?Why is this relevant for statisticians working in CROs, pharma or as consultants? How can content help CROs or consultants win more business? How can content help you attract candidates to your team and stand out as an employer?How can content help to boost your personal profile? What are the barriers that stop people from implementing content marketing and how we overcome these barriers? What actions do you recommend should stati...2020-02-1047 minThe Effective Statistician - in association with PSIImpact of AI on Clinical DevelopmentInterview with Karim Malki
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Karim shares about his career, his roles, and different approaches and methods. We also discuss the following points:
Machine learningAIPredictive analyticsData scienceDifferent statistical methods and limitationsDifferent tools and applications Statistical innovation
Listen to this episode, learn from it, and share it with others!
2020-02-0344 minThe Effective Statistician - in association with PSIThe data ops manifestoInterview with Christopher Bergh
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The data ops manifesto can be found here and lists these 18 points - some of which are discussed in more detail in this episode.
Data Ops Principles:
Continually satisfy your customerValue working analyticsEmbrace changeIt's a team sportDaily interactionsSelf-organizeReduce heroismReflectAnalytics is codeOrchestrateMake it reproducibleDisposable environmentsSimplicityAnalytics is manufacturingQuality is paramountMonitor quality and performanceReuseImprove cycle times
2020-01-271h 02The Effective Statistician - in association with PSI6 Effective leadership behaviours for statisticians
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The 6 behaviours we’re speaking about are:
Being confidently relaxedBeing decisiveBeing knowledgeableBeing friendlyBeing curiousBeing vulnerable
Here’s the link to the TED talk by Brene Brown, which was watched already over 44 million times (status November 2019):
https://www.ted.com/talks/brene_brown_on_vulnerability?language=en#t-68179
Listen to this episode and share it with others who might learn from it!
2020-01-2033 minThe Effective Statistician - in association with PSIHelping statisticians having a bigger roleInterview with Andy Grieve
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Today's interview is surely beneficial to everybody. Andy Grieve has a lot of experiences across the industry as academia and other senior roles.
We also talk about the following points:
When did you realize for yourself, that statisticians should and can play a bigger role?How would the health sector look like, if statisticians would have considerably more influence - e.g. if all the pharma companies would have something like a chief statistical officer?What are the factors...2020-01-141h 03The Effective Statistician - in association with PSIOverview of different indirect comparison approaches and methods
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We specifically address the following points:
Reasons for IC The classical Bucher approach vs matching adjusted indirect comparisons (MAIC)How to incorporated meta-analysesDifferent network-meta-analyses approaches (NMA): Bayes vs Frequentistsystematic literature reviews (SLR)Cochrane handbookTools
2020-01-0640 minThe Effective Statistician - in association with PSIChristmas episode 2019
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During this episode, we will review some of the highlights from this year. It’ll help you to remember a couple of lessons learned or inspire you to listen to some episodes (again).
We will talk about the following:
LeadershipThe look beyond pharmaData scienceBenefit-RiskCareerNonparametricVisualizationProductivityAnd an outlook into 2020
Otherwise, enjoy your Christmas break and we’re taking a week off on New year's eve and start again on the seventh of January.
Listen to this episode and become an effe...2019-12-2447 minThe Effective Statistician - in association with PSICALC Episode 5: You’re hired! How to Fail to be Rejected During the Interview ProcessSo, hopefully you’ve listened to all of our other podcasts and you are still interested in applying for a job as a medical statistician…
This episode will give you all the information you need to find out how to apply, CV tips and what to expect at the interview, and what to do and what not to do!2019-12-1941 minThe Effective Statistician - in association with PSIBaseline testingA widespread but difficult to treat disease
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I once reviewed tables for a randomized study and noticed several comments about testing the baseline characteristics. The commenters were arguing which test would be best to test for the differences between the 2 randomized groups at baseline.
This made my first angry about the wasted time and then curious about the reasons, statisticians still do this.
In today's episode, Benjamin and I discuss some backgrounds for baseline testing in randomized studies.
Listen to...2019-12-1722 minThe Effective Statistician - in association with PSISeeing through the mist - consequences of decisions in phase IIInterview with Trevor Smart
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In this episode, Trevor and I discuss a case study to go through the step by step procedure of phase II. We also talk about the following points:
What are decision rules?How can we use prior elicitation?What and how do you come to a prior distribution and what is a design prior?What role do relevant and non-relevant differences play here?Any recommended reading?What does the listener need to do differently to make sure, better decisions are made...2019-12-0951 minThe Effective Statistician - in association with PSICALC Episode 4: Be Significant: What Employers Look forSo, you want to be a Statistician in the pharmaceutical industry, a key player in drug research and development, but you are wondering what employers look for in the perfect candidate?
PSI CALC are here to share their top tips on being the ideal candidate, what to expect when you apply and to share their ideas of what the industry is currently looking for in a graduate statistician.2019-12-0530 minThe Effective Statistician - in association with PSIHow to leverage time-boxing to reduce overwhelm being a statisticianBatch processing and scheduling tasks to fight procrastination
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In today's episode, we discuss time boxing and batch processing. We also discuss how these following points work:
Schedule your tasks in your calendar Meetings with yourself Combination of smaller tasks Chunks of 15 minutes Can also be applied to meetings (strict agendas)
Benefits of the following:
Allocate the right amount of time in the right moments (e.g. emails after lunch and hard cognitive SAP writing in the morning) Save space for the...2019-12-0257 minThe Effective Statistician - in association with PSIHow to get into flow and reach peak performanceAlexander and Benjamin
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This is awesome for everybody, most especially, for brain workers. We also talk about the following points:
What is the flowWhy is it importantWhen are we inflowPersonal examplesThe sweet spot between challenge and skillThe role of passionThe role of undistracted time and placeHow to manage distractionsFocus on the tasks as long as possibleBe in the momentEnjoy the experienceKeep practicingAcknowledge the rewardsIndividual vs group flow
Listen to this episode now and be an effective Statistician!2019-11-2529 minThe Effective Statistician - in association with PSICALC Episode 3: Get a Head Start and Map Your Route to a Career in Drug DevelopmentSo, you’re considering pursuing a career in Statistics but you’re not quite sure. You may be at Uni studying a BSc in Mathematics or a related field, or you may be considering a change in career. How do you get from where you are now to being a Statistician in the medical industry? What are your next steps?
This episode will cover what to start thinking about now, where you can get further advice on MSc courses and funding and where you can search for jobs.2019-11-2119 minThe Effective Statistician - in association with PSIWhat you need to know before you try to increase productivityVital tips with Alexander and Benjamin
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Do you often find your workday spiraling out of control? Do you want to be more productive than you yesterday?Do you want to know how to improve your skill set and work performance?Do you start each day with a plan, but soon become distracted and procrastinating?You are not alone. Sometimes, it’s easier to wait for someone else to tell you what things you should work on rather than to assess yourself. ...2019-11-1943 minThe Effective Statistician - in association with PSIHow to lead being an introvertInterview with Fritz Lehmann
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Now, how is it possible for introverted leaders to succeed in the workplace? In today's episode, I discuss with Fritz these key points:
How to assess yourself if you’re an introvertWhat are the strengths as introverts, which can be utilized to the advantage in terms of leadershipTips on minimizing limitations being introvertsSome mindset shifts which we are needed to make as introverts to become leaders
Listen and be an effective statistician!2019-11-1143 minThe Effective Statistician - in association with PSICALC Episode 2: The Average Day for a Statistician: It’s Not Mean!Statistics isn’t traditionally known to be a trendy subject, but here we are saving lives around the world by developing new and mighty medicines. You’ve probably heard by now that data is basically gold, and fortunately we statisticians work with data.
Now that’s a lot of power we hold, so let’s put it to good use!
- What kind of companies are out there?
- Statistics is needed to produce revolutionary new medicines - yes, really!
- Will I be at a desk all day, on my own, in a windowless room?
- What’s a typical da...2019-11-0742 minThe Effective Statistician - in association with PSINetwork meta-analyses: why, what, and howInterview with Georgia Salanti
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In today's episode, I discuss with Georgia the following:
Key assumptions for network meta-analysesAssess, that these assumptions are met - inconsistency and graphical approachesTools to run an NMAThe starters need to read about NMAsResources at the ISPM
Listen to this episode to know more about how you can leverage NMAs and share this with others who might learn from it!
2019-11-0453 minThe Effective Statistician - in association with PSIHow to resolve conflict without giving inWebinar with Gary
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Different ideas, stories, and concepts around conflict resolutionCreative listening helps you understand where the other person is coming from- what is their interest and meeting their interestStrategically use feelings but not being driven by feelings when resolving conflicts Question and answer portion on how to manage conflict well
Listen to this episode and learn strategies on how to resolve conflict without giving in!
2019-10-281h 04The Effective Statistician - in association with PSICALC Episode 1: From Molecule to Patient: The Statistician’s Role in Developing New MedicinesHow do we develop new medicines to treat nasty diseases? It all starts by discovering a novel target molecule in the lab. Fast forward 12 years and an average expenditure of 1.5 billion dollars we hopefully get the thumbs up from health authority bodies to license the medicine for public use.
So we skipped a lot of important steps there. The journey for developing new medicines is extremely lengthy and complicated. Fortunately, you can listen to this podcast and know all the important stuff in 20 minutes!
Statisticians are involved in all aspects of drug development. Having knowledge of the process from start...2019-10-2437 minThe Effective Statistician - in association with PSICurrent trends in pharmaceutical and how they will affect you as a statisticianInterview with Richard Zink
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In this discussion, we’re covering a wide range of topics:
Probabilistic matchingPropensity scoringRWE before and after approvalUnderstanding populations outside of RCTsUnderstanding background treatments and rates of adverse eventsAugmenting RCTs with RWEData from different data sourcesData from Devices and wearablesNatural language processing and unstructured wayPragmatic trialsAI and machine learningData scienceBusiness analyticsPrices of productsCost-effectiveness and budget impact modelsUmbrella studies
Listen to this episode and learn to be an effective statistician!
2019-10-221h 09The Effective Statistician - in association with PSINatural language processing - how the analyses of unstructured text data can help usInterview with Jennings Xu
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In this episode, I speak with Jennings Xu, who works as a Director in Quid - an AI natural language processing company. Here are the points you can learn from the interview:
What is zettabyteWhat are the different modes of dataWhere in the medical field is the biggest problem amongst text dataWhat are the other concepts used in text miningWhat is the difference between text mining and natural language processing
Listen to this episode and share it with someone who might benefit...2019-10-1536 minThe Effective Statistician - in association with PSICALC Episode 0: Introduction to PSI CALC Podcast SeriesDo you have a passion for numbers and want to save lives?
Click here to get to the homepage of the episode2019-10-1004 minThe Effective Statistician - in association with PSIWhat statisticians can learn from Leonardo Da VinciInterview with Tricia Aanderud
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In this episode, Benjamin and I speak with Tricia Aanderud, a very good data storyteller. Here are the points you can learn from the interview:
How to think about the story within the dataHow to reveal your Aha momentsHow to get into details while keeping the big pictureHow to build tension and have an impact on the visualization
2019-10-0839 minThe Effective Statistician - in association with PSILearning from Leonardo Da VinciInterview with Tricia Aanderud
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Storytelling is one of the great leadership skills that play a role in communication. Through stories, you can create alignment and you can influence others. It's one piece of a puzzle to be an effective statistician.
In this episode, Benjamin and I speak with Tricia Aanderud, a very good data storyteller. Here's what you can learn from the interview:
How to think about the story within the dataHow to reveal your Aha momentsHow to get into details while keeping the...2019-10-0739 min
The Effective Statistician - in association with PSIStatisticians stepping up - leadership success stories - Part 2Interview with Shahrul and Vanja
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In this episode, I'm speaking with two members of The Effective Statistician Leadership program. One is coming from academia and one is from a pharmaceutical organization - they both have interesting and inspiring success stories.
These are the points we have talked about:
How they took action to improve on their leadership programHow to help others understand your storyHow to refine things from other's reaction What impact the improvements in your leadership skills can have on your lives
2019-09-3043 minThe Effective Statistician - in association with PSIStatisticians stepping up - leadership success stories - Part 1Interview with Ludi and Sam
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These are the points we have talked about:
What they find most helpful about the programWhat skills they have improved onWhat they learned from the leadership assignmentsWhat they think about the mastermind conceptWhat they learned about business acumenHow the program helped them to have more influence at work
Listen now and be inspired to become a leader.
2019-09-2338 min
The Effective Statistician - in association with PSI4 reasons why statisticians fail to leadWebinar recording with Gary Sullivan
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In this episode, Gary and I will be talking about these major reasons why statisticians fail to lead and to overcome them. Specifically, we'll address:
MindsetBias toward technical skillsLack of leadership understandingLack of big picture thinkingHow to address the issuesSpecific actions to take
Listen to this episode and learn about the opportunities to overcome challenges in leadership!
2019-09-1640 minThe Effective Statistician - in association with PSIDon't be a victimDo you actively kill your career without knowing it?
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According to Jon, the key is to differentiate between some venting, that we need from time to time, from systemically and constantly complaining.
Take this Power of Positive Leadership Self-Assessment and complete the questions to know your Positivity Quotient Score. By knowing your score you will be able to establish a baseline for growth. You'll also receive Jon Gordon's 6 Quick Tips to Help Stop Negativity in It's Tracks.
In this episode, Benjamin and I...2019-09-0941 minThe Effective Statistician - in association with PSINon-parametric analyses - much more than just the Wilcoxon test!Interview with Frank Konietschke
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Frank has something in common with Benjamin and myself - we all studied statistics in Göttingen and learned and researched in non-parametric statistics. Afterwards, we went into different paths. Whereas Benjamin started at a CRO and I joined large pharma organizations, Frank continued on the academic track.
He recently became Professor at the famous Charitee in Berlin, where he’s still dedicating a lot of research to the field of non-parametric statistics. However, he’s not an ivory tower researcher but also appli...2019-09-0349 minThe Effective Statistician - in association with PSITaking the pain out of subgroup analysesInterview with Necdet Gunsoy
This episode is based on a presentation at PSI 2019. Necdet won The Effective Statistician Best Presenter award for the amazing delivery of the presentation. But not only the delivery was excellent - the content will help you a lot. Here's the abstract for the conference:
Abstract: Practical aspects of subgroup detectionRecent years have seen the emergence of new methods for detecting subgroups with enhanced treatment effects and statisticians are now faced with an overwhelming choice of approaches to consider. Confusion around the potential advantages and disadvantages of different methods can often...2019-08-261h 02The Effective Statistician - in association with PSIMy story of the Effective StatisticianWhy I started The Effective Statistician and what you can learn from it
Click here to get to the homepage of the episode!
It all started when I became a new supervisor and had my first direct reports and I thought I really needed to learn about supervisory skills but I have very limited time. I found out that podcasts really help a lot to learn while I commute to work - it's effective.In this podcast, you can learn a lot from the following:
What are my learnings along the way?What...2019-08-1925 minThe Effective Statistician - in association with PSIWhat matters most? A scientific advice role play on estimandsReplay from the PSI conference 2018
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Are you a sponsor who is seeking joint scientific advice from a regulatory agency and from an HTA body?
If yes, this episode is for you. This presentation replicates the discussions which may go on during scientific advice. The example was in Respiratory. This roleplay is played by David Wright, Oliver Keene, Stephen Ruberg, and myself. The aim is to show a couple of discussion points and an interesting aspect that may come up with such discussions.
2019-08-121h 01The Effective Statistician - in association with PSIHow to become a leader in a cross-functional teamPeople who ask take the lead
Click here to get to the homepage of the episode!
People who ask take the lead
You can lead as well. According to Forbes, best leaders lead with questions, not answers. Leading with questions works because really good questions have a direct impact on the brain. When we are challenged by a question that triggers an insight, neurons connect in new ways. This releases neurotransmitters that create the motivation to act. The net result is that the other person not only likes the idea, but they also want to...2019-08-0533 minThe Effective Statistician - in association with PSIHelp to make your organisation and yourself outsourcing proofIf you think of yourself as your own organisation – can you make yourself outsourcing proof?
Click here to get to the homepage of the episode!
A lot of statisticians, especially in pharmaceutical companies but also CROs, fear outsourcing because it might make their job redundant. Think about:
In this episode, Benjamin and I will be talking about these tips and tricks:
Benjamin and I will be talking about these tips and tricks:
What are the things, that are done better, faster and cheaper by others? Does your supervisor know about your va...2019-07-2930 minThe Effective Statistician - in association with PSIHow to communicate effectively by telling data storiesInterview with Kat Greenbrook
Storytelling allows businesses to better understand insight.
Data visualization is a great tool to help share, or tell a story, but relies on the story being written first. Improved data communication comes from combining good visualization with a well-written narrative.
At storytelling with data, the goal is to rid the world of ineffective graphs and help people elegantly communicate with data. They aim to bring data to life and use it to tell a story to an audience, with a focus on simplicity and ease of interpretation. They believe everyone can...2019-07-2245 minThe Effective Statistician - in association with PSIHow to make the collaboration between sponsor and CRO successful
Click here to get to the homepage of the episode!
There is an endless list of things that can go wrong.I'm pretty sure you have been in painful discussions about this.Have you felt a lot of frustrations on both ends?
Benjamin works for the CRO and I work for the sponsor side. In this episode, we will be giving you a lot of insights on what to do and what not to do, and how to make collaboration between the sponsor and CRO successful.
Specifically, Benjamin and I will...2019-07-151h 08The Effective Statistician - in association with PSIBest of PSI 2019“Data Driven Decision Making in Medical Research”
Click here to get to the homepage of the episode!
In this series of interviews with the speakers at the conference, we talked about different topics:
Visualization softwareBenefit risks approachGlobal statistical test for multiple endpoint analysisEstimandsAE analysis using a volcano plot
I also talked to Rachel Phillips at the PSI conference. She is an NIHR doctoral research fellow at Imperial College London. Please help her with her study. It will help all of us in the end and you can win something!
This is a survey of c...2019-07-0931 minThe Effective Statistician - in association with PSIMistakes – How to minimize them – How to manage themDiscussion between Benjamin and Alexander
Do you agree that everybody makes mistakes?Have you had to deal with a mistake yourself, that you were really concerned about?Were you afraid about speaking with your supervisor or your team with it?
We are all imperfect humans making mistakes. The questions are:
how do we deal with them, what we can do about them, and what to do to minimize them.
Processes are made to minimize mistakes and there different processes were set up to deal with mistakes and help you when mistakes occur.
2019-07-0239 minThe Effective Statistician - in association with PSIPresenting with impact: 7 mistakes to avoidInterview with Julia Carter
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Have you been sitting in boring presentations that made you start reading your emails? Have you been listening to someone, wondering if this is for me?Have you been getting away from a presentation and thinking 2 hours later: “what was this about?”
You’re surely don’t want your audience to feel this way, when you’re
presenting yourself. You can’t be an effective statisticians without good presentation
skills from my perspective. You will always need to present results, def...2019-06-2547 minThe Effective Statistician - in association with PSIJoin the abstract writing challenge!Let's write an abstract together
Join the abstract writing challenge here!
The last PSI conference has just ended, but the timeline for a new abstract submission for the next one in Barcelone in 2020 will come up in about November 2019. Thus, it’s important to now start thinking about it.
Presenting at the PSI conference is an awesome experience. For me, PSI is by far the best conference for statisticians in the health sector as it is 100% applicable and actionable. If you’re abstract gets accepted for oral presentation or as a poster, you have a grea...2019-06-2005 minThe Effective Statistician - in association with PSIAre you up for a job change? Insights from a recruiterInterview with Jack Corbett
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I recently changed my job and moving from one company to another comes with lots of uncertainty.
Will I pick the right one?
How can I make sure, that I actually get the job, that I want?
Will hiring companies find me and offer me jobs?
For any statistician a job change represent a major shift and occurs rather infrequent – hopefully. For a recruiter – this is day-to-day business.
Look out for lots of great learnings and insights!2019-06-1845 minThe Effective Statistician - in association with PSIHow to work effectively as and with a placement studentA success story with Katie and Claire
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Have you ever considered to work with a placement student?
Do you consider to spend some time as a placement student yourself?
In this interview with Katie Thorn and Claire Brittain, we’re exploring factors, which help to make it a win for both sides. Both have worked very well together and share their stories.2019-06-1137 minThe Effective Statistician - in association with PSIQuestions to ask yourself before starting a new projectto make the best of your time
Click here to get to the homepage of the episode!
I recently talked to a statistician, that initiated a small company internal group of statisticians to drive forward methodological innovation projects. While this surely will help the individuals to learn more about statistical methods, it was less clear, why and on which topics the group should focus their activities on.
While most of our day-to-day activities consists of running clinical studies, submissions and directly related work, we also engage in such innovation work streams or process improvement working...2019-06-0429 minThe Effective Statistician - in association with PSIUnderstanding heterogeneity for patient preference data and how it effects the benefit-risk ratio for treatmentsInterview with Marco Boeri
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As
statisticians in the medical field, we’re used to study subgroups of patients
with respect to all kinds of biological variables: from demographics to
genomics. This provides us with a good understanding of how the benefit-risk
profile for a given patient looks like.
However,
the patient might have a completely different view on the importance of the
different benefits and risks. And importantly, these preferences might be less
driven by biologic factors and more by personal experiences and situations as
we...2019-05-2853 minThe Effective Statistician - in association with PSIUseful tips to apply the composite estimand approachInterview with Michael O'Kelly
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Estimands continue to be a hot
topic, but many statisticians struggle to put it into practice. As
statistician, we wonder about the correct interpretation and how to analyse
different estimands.
In todays episode, we speak with Michael
O’Kelly, an expert on this topic with lots of presentations around estimand
(see e.g. the PSI events). He also won the award for Statistical Excellence in
the Pharmaceutical Industry, jointly run by the RSS and Statisticians in the
Pharmaceutical Industry (PSI).
2019-05-2156 minThe Effective Statistician - in association with PSIAdvanced approach for subgroup analyses in easy steps - SIDESInterview with Andy Nicholls
Click here to get to the homepage of the episode.
One of the most common questions I got asked during my nearly 2 decades of being a statistician sounds similar to this: “Which patients have the best response to treatment?”
I’m sure, we all face this situation sooner or later and not surprisingly lots of research has happened in the last years on this area. In todays episode, we will help you to understand one of the best approaches I have come across to solve this problem in a rigorous yet sophis...2019-05-1457 minThe Effective Statistician - in association with PSI50 shades of pre-specificationInterview with Lovisa Berggren
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Prespecified=good and post-hoc=bad. This is how we as statistician see it usually and I did too. However, over the past years I realized more and more, that it’s not that easy.
How many details do you need to have to call an analysis pre-specified? Should we label a request to analyse a certain subgroup by regulators as well as a fishing expedition to find a significant subgroup both in the same way: post-hoc?
Lovisa and I to...2019-05-0733 minThe Effective Statistician - in association with PSIHow to best analyze ordinal dataOvercoming the simplification strategy
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Analysing binary or
continuous data usually doesn’t cause any headaches for statisticians. But when
we step into ordinal data, most of us ignore their specific nature and either
dichotomize them or analyse them as if they are continuous.
Recently, these
problems have becoming much more prevalent due to the nature of composite
endpoints (watch out for an interesting episode on this in a few weeks).
Now Benjamin and I
have worked on better tools to analyse such data al...2019-04-3034 minThe Effective Statistician - in association with PSIWhat you should know about risk-based monitoring!Interview with Tim Rolfe
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Risk-based
monitoring plays an increasingly important role for clinical trials. Of course,
the assessment of the risk is based on statistics. This presents now only
interesting career options for statisticians, but also has an impact on the
role of statisticians in study teams.
In this episode, we’ll give you an introduction to risk-based monitoring (RBM) as well as speak about the role of statisticians in this area. Further we provide you as a study statistician insights into what you need to...2019-04-2346 minThe Effective Statistician - in association with PSIHow to train non-statisticians effectively - 11 tips to succeedExperiences from many trainings summarized
Click here to get to the homepage of the episode!
Start with a relevant example
Collect questions upfront and track progress of answering them during the training
Create regular meetings to engage people
Interrupt your presentations with asking questions
Use contrasts to show the impact
Have a physician first introduce the example study
Don’t shy away from speaking to very basic things like p-values
Prefer white board over slides
Use technology for your advantage in virtual settings
Make pre-read easy
Collect feedback
2019-04-1648 minThe Effective Statistician - in association with PSIWhy and how to understand patient preferencesInterview with Brett Hauber
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Ultimately, we work to improve patients lives but
traditionally the voice of the patient was not important. However, over the
last decades many stakeholders shift to include the patient more in the decision-making
process and patients voice their needs and preferences more.
Still capturing and evaluating patient preferences does not belong to the core capabilities of most biostatisticians. This episode will help you to understand patient preferences.
2019-04-0935 minThe Effective Statistician - in association with PSIDoes getting a PhD help you long term? Pro vs ConWhat aspects to consider?
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Are you early in your career and you could still go for a PhD in statistics?
Do you wonder, if this pays out short and long-term?
Is it worth the money?
What are the long-term benefits or are there actually short term benefits as well?2019-04-0234 minThe Effective Statistician - in association with PSIWhat is the best career option for me?Interview with Oliver Schoenborn-Kellenberger
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Do you want to change your job?
Are you just looking for you first job?
Do you consider to work for your own company or as a free-lancer?
Then this episode will help you!2019-03-2639 minThe Effective Statistician - in association with PSIIntroduction to Benefit-Risk AssessmentInterview with Maria Costa and Shahrul Mt-Isa
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Benefit-risk assessments are made by various stakeholders including sponsors, regulators, payers, physicians, and patients throughout the life-cycle of a treatment.
The understanding of data plays a vital role in weighting positive and negative effects of medications.
In this episode, we give you an introduction to what benefit-risk (BR) assessment is in order for you to understand your role.2019-03-1954 minThe Effective Statistician - in association with PSIHow to get most out of a conferenceInterview with Kate Taylor – chair of the PSI conference in 2019
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In this episode, we talk about
how to network
how to prepare for the conference
how to
follow up after the conference
As well as some specific topics around the PSI conference itself.2019-03-1245 minThe Effective Statistician - in association with PSIIntroduction to cluster analysisNot all patients are created equal, but are there subgroups that are more homogenous?
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This episode follows the outline of a webinar, that I presented in 2018 during a PSI webinar. I’m introducing cluster analysis and why you as a statistician need to know about it.2019-03-0545 minThe Effective Statistician - in association with PSIData science or just statistics on non-medical data? A new horizon for statisticiansInterview with Stephen Ruberg
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There’s a long tradition of statisticians working on clinical studies as well as other related data, e.g. pre-clinical data and observational data. In the advent of big data and data sciences, there’s a considerable pull from the business side of pharma to employ statistical approaches as well.
What does this mean for medical statisticians?2019-02-2659 minThe Effective Statistician - in association with PSICurrent trends in data science for pharma – findings from a qualitative survey and what we should do about it!Interview with Ursula Garczarek
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Do you want to learn where the health sector might be heading in terms of data science?
Do you understand the opportunities and barriers in terms of the application of data science?
Are you prepared to learn the individual skills needed for these changes?
Then this interview with Ursula from Cytel provides you with the relevant answers.2019-02-1946 minThe Effective Statistician - in association with PSIWhat you can learn about communication of statistics from a statistician working for the BBCInterview with Robert Cuffe
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It's surely not the norm, that a statistician from the pharma sector ends up working for BBC. But Robert Cuffe has taken this step and needs to explain statistics to non-statisticians on a daily basis.
In this episode, he shares the different methods he’s using. We also dive into common pitfalls, that we as statisticians trap into.
Finally, we also learn, how we can improve our publications to make sure, that the science is reported correctly in...2019-02-1226 minThe Effective Statistician - in association with PSIWhat is TransCelerate and how it will impact your work tremendouslyInterview with Pepa Polavieja
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Do you know that TransCelerate does for statisticians?
Do you write study protocols, analysis plans and programming specifications as individual documents noting, that there’s lots of redundancy?
Do you wonder, if there’s a more efficient was in-line with what regulators want?
Pepa Polavieja will provide you with answers to all these questions in this episode.2019-02-0530 minThe Effective Statistician - in association with PSIThe rise of R and what role the AIMS SIG plays in itInterview with Lyn Tailor and Craig McIlloney
Click here to get to the homepage of the episdode!
Do you think, R can’t be used for regulatory submissions?
Are you forced to use SAS but would like to use R instead?
Would you like to understand how you can make R submission proof?
Then this interview with Lyn Tailor and Craig McIlloney helps you.
Both work on the PSI special interest group Application and Implementation of Methodologies in Statistics (AIMS) on this topics.2019-01-2949 minThe Effective Statistician - in association with PSIPractical steps to improve your leadership skillsInterview with Gary Sullivan
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In this last part of the leadership series with Gary Sullivan, we talk about the next steps, you can take to work on your leadership skills.2019-01-2250 minThe Effective Statistician - in association with PSISkills you need to become a better leader!Interview with Gary Sullivan
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In the third part of the leadership series with Gary Sullivan, we talk about:
What skills does it takes to influence as a statistician?When it’s about driving change - what are the rational, operational, and emotional challenges?How do I get a "seat at the table" and have more influence?
Thus, you will exactly know what to work on after this episode.
Watch out for next weeks episode as we’ll have something for you to accelerate your...2019-01-1550 minThe Effective Statistician - in association with PSIUnderstanding leadership deeply: trust, relationship, influence for statisticiansInterview with Gary Sullivan
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In this second part of the interview with Gary (check here for part 1), we speak about the building blocks of leadership without authority from a statistician’s perspective. We cover questions like:
Is influence the same as power?What is the role of trust, what are the different elements of trust and how can we improve trust being technical experts?How can we build relationships at work, that help us to influence change?Is influence through relationships only relevant “sideways” or also “upwards” and “downwards”?H...2019-01-0845 minThe Effective Statistician - in association with PSIFree webinar: 4 reasons why statisticians fail to lead and how to overcome them!Presented by Gary Sullivan and Alexander Schacht
This is an announcement episode of an upcoming free webinar. Learn more about this webinar and register for it at theeffectivestatistician.com/webinar.2019-01-0401 min