airwayamlburdenchallengesclinicalcliniciancomorbiditiescopdcurrentdiscussiondiseaseearlyeffortevidenceexploringgeneralizedguidelinesicsimpactinflammationinfluencemanagementmanagingpatientpatientspsoriasispustularroleschizophreniatargetedtherapytreatmenttreatmentsunderstandinguse